PMC:1540739 / 213-476 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T479","span":{"begin":0,"end":5},"obj":"VBG"},{"id":"T480","span":{"begin":6,"end":16},"obj":"JJ"},{"id":"T481","span":{"begin":17,"end":30},"obj":"NN"},{"id":"T482","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T483","span":{"begin":34,"end":36},"obj":"NN"},{"id":"T484","span":{"begin":37,"end":42},"obj":"NNS"},{"id":"T485","span":{"begin":43,"end":45},"obj":"TO"},{"id":"T486","span":{"begin":46,"end":54},"obj":"VB"},{"id":"T487","span":{"begin":55,"end":61},"obj":"JJ"},{"id":"T488","span":{"begin":62,"end":66},"obj":"NNS"},{"id":"T489","span":{"begin":66,"end":67},"obj":"."},{"id":"T490","span":{"begin":67,"end":139},"obj":"sentence"},{"id":"T491","span":{"begin":68,"end":76},"obj":"IN"},{"id":"T492","span":{"begin":77,"end":88},"obj":"JJ"},{"id":"T493","span":{"begin":104,"end":106},"obj":"VBZ"},{"id":"T494","span":{"begin":88,"end":90},"obj":","},{"id":"T495","span":{"begin":90,"end":94},"obj":"DT"},{"id":"T496","span":{"begin":95,"end":103},"obj":"NN"},{"id":"T497","span":{"begin":107,"end":118},"obj":"JJ"},{"id":"T498","span":{"begin":118,"end":120},"obj":","},{"id":"T499","span":{"begin":120,"end":124},"obj":"JJ"},{"id":"T500","span":{"begin":125,"end":128},"obj":"CC"},{"id":"T501","span":{"begin":129,"end":138},"obj":"JJ"},{"id":"T502","span":{"begin":138,"end":139},"obj":"."},{"id":"T503","span":{"begin":139,"end":260},"obj":"sentence"},{"id":"T504","span":{"begin":140,"end":142},"obj":"TO"},{"id":"T505","span":{"begin":143,"end":153},"obj":"VB"},{"id":"T506","span":{"begin":185,"end":194},"obj":"VBD"},{"id":"T507","span":{"begin":154,"end":163},"obj":"NN"},{"id":"T508","span":{"begin":164,"end":166},"obj":"IN"},{"id":"T509","span":{"begin":167,"end":170},"obj":"DT"},{"id":"T510","span":{"begin":175,"end":180},"obj":"NN"},{"id":"T511","span":{"begin":171,"end":174},"obj":"NN"},{"id":"T512","span":{"begin":180,"end":182},"obj":","},{"id":"T513","span":{"begin":182,"end":184},"obj":"PRP"},{"id":"T514","span":{"begin":195,"end":197},"obj":"DT"},{"id":"T515","span":{"begin":253,"end":259},"obj":"NN"},{"id":"T516","span":{"begin":198,"end":206},"obj":"VBN"},{"id":"T517","span":{"begin":207,"end":218},"obj":"NN"},{"id":"T518","span":{"begin":219,"end":227},"obj":"JJ"},{"id":"T519","span":{"begin":218,"end":219},"obj":"HYPH"},{"id":"T520","span":{"begin":237,"end":245},"obj":"NNP"},{"id":"T521","span":{"begin":228,"end":236},"obj":"NNP"},{"id":"T522","span":{"begin":246,"end":247},"obj":"-LRB-"},{"id":"T523","span":{"begin":247,"end":251},"obj":"NN"},{"id":"T524","span":{"begin":251,"end":252},"obj":"-RRB-"},{"id":"T525","span":{"begin":259,"end":260},"obj":"."}],"relations":[{"id":"R39","pred":"amod","subj":"T480","obj":"T481"},{"id":"R40","pred":"dobj","subj":"T481","obj":"T479"},{"id":"R41","pred":"prep","subj":"T482","obj":"T479"},{"id":"R42","pred":"compound","subj":"T483","obj":"T484"},{"id":"R43","pred":"pobj","subj":"T484","obj":"T482"},{"id":"R44","pred":"aux","subj":"T485","obj":"T486"},{"id":"R45","pred":"advcl","subj":"T486","obj":"T479"},{"id":"R46","pred":"amod","subj":"T487","obj":"T488"},{"id":"R47","pred":"dobj","subj":"T488","obj":"T486"},{"id":"R49","pred":"mark","subj":"T491","obj":"T492"},{"id":"R50","pred":"advcl","subj":"T492","obj":"T493"},{"id":"R51","pred":"punct","subj":"T494","obj":"T493"},{"id":"R52","pred":"det","subj":"T495","obj":"T496"},{"id":"R53","pred":"nsubj","subj":"T496","obj":"T493"},{"id":"R54","pred":"acomp","subj":"T497","obj":"T493"},{"id":"R55","pred":"punct","subj":"T498","obj":"T497"},{"id":"R56","pred":"conj","subj":"T499","obj":"T497"},{"id":"R57","pred":"cc","subj":"T500","obj":"T499"},{"id":"R58","pred":"conj","subj":"T501","obj":"T499"},{"id":"R59","pred":"punct","subj":"T502","obj":"T493"},{"id":"R60","pred":"aux","subj":"T504","obj":"T505"},{"id":"R61","pred":"advcl","subj":"T505","obj":"T506"},{"id":"R62","pred":"dobj","subj":"T507","obj":"T505"},{"id":"R63","pred":"prep","subj":"T508","obj":"T505"},{"id":"R64","pred":"det","subj":"T509","obj":"T510"},{"id":"R65","pred":"pobj","subj":"T510","obj":"T508"},{"id":"R66","pred":"compound","subj":"T511","obj":"T510"},{"id":"R67","pred":"punct","subj":"T512","obj":"T506"},{"id":"R68","pred":"nsubj","subj":"T513","obj":"T506"},{"id":"R69","pred":"det","subj":"T514","obj":"T515"},{"id":"R70","pred":"dobj","subj":"T515","obj":"T506"},{"id":"R71","pred":"amod","subj":"T516","obj":"T515"},{"id":"R72","pred":"npadvmod","subj":"T517","obj":"T518"},{"id":"R73","pred":"amod","subj":"T518","obj":"T520"},{"id":"R74","pred":"punct","subj":"T519","obj":"T518"},{"id":"R75","pred":"nmod","subj":"T520","obj":"T515"},{"id":"R76","pred":"nmod","subj":"T521","obj":"T520"},{"id":"R77","pred":"punct","subj":"T522","obj":"T520"},{"id":"R78","pred":"appos","subj":"T523","obj":"T520"},{"id":"R79","pred":"punct","subj":"T524","obj":"T515"},{"id":"R80","pred":"punct","subj":"T525","obj":"T506"}],"text":"using homologous recombination in ES cells to generate mutant mice. Although informative, this approach is inefficient, slow and expensive. To facilitate targeting at the p53 locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Ou"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T413","span":{"begin":17,"end":30},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T414","span":{"begin":34,"end":42},"obj":"CL:0002322"},{"id":"T415","span":{"begin":37,"end":42},"obj":"CL_GO_EXT:cell"},{"id":"T416","span":{"begin":55,"end":61},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T417","span":{"begin":62,"end":66},"obj":"NCBITaxon:10088"},{"id":"T418","span":{"begin":171,"end":174},"obj":"PR_EXT:000003035"},{"id":"T419","span":{"begin":207,"end":218},"obj":"GO_EXT:recombinase"},{"id":"T420","span":{"begin":228,"end":236},"obj":"SO_EXT:0005853"},{"id":"T421","span":{"begin":237,"end":245},"obj":"SO_EXT:sequence_substitution_process"}],"text":"using homologous recombination in ES cells to generate mutant mice. Although informative, this approach is inefficient, slow and expensive. To facilitate targeting at the p53 locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Ou"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T391","span":{"begin":34,"end":42},"obj":"CL:0002322"},{"id":"T392","span":{"begin":62,"end":66},"obj":"NCBITaxon:10088"},{"id":"T393","span":{"begin":171,"end":174},"obj":"PR:000003035"},{"id":"T394","span":{"begin":228,"end":236},"obj":"SO:0005853"}],"text":"using homologous recombination in ES cells to generate mutant mice. Although informative, this approach is inefficient, slow and expensive. To facilitate targeting at the p53 locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Ou"}