PMC:1482699 / 62357-63392 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1482699","sourcedb":"PMC","sourceid":"1482699","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1482699","text":"Table 7 Nonsynonymous SNP in MMU2, 9 and 17 hg modifier candidate genes predicted by SIFT and Polyphen to alter protein function\nGene MMU Mbp AAÄa B6/CASTb Polyphen CAST/B6 Polyphen B6/CAST SIFT CAST/B6 SIFT\nNmi 2 52.0 R243C B B T D\nMtx2 2 74.7 T1099M PSD PSD T D\nUbr1 2 120.6 A1371T B B D T\nPtpns1 2 129.3 H224N PBD PBD T T\nUbce7ip5 2 130.3 A314P PSD PSD T T\n2 I366T B B T D\nPlcg1 2 160.5 T1165A B B T D\nMmp9 2 164.7 A514P B B D D\n2 P639L PBD PBD T T\nTyk2 9 21.0 R234H PSD PSD T T\nC831S PSD PSD T T\nT1099M PSD PSD T D\nVav 17 55.5 Q29H PSD PBD T T\nQ53H PBD PSD T T\nQ65H PBD PSD T D\nMMU, mouse chromosome; AA, amino acid; PBD, probably damaging, PSD, possibly damaging; B, Benign; T, tolerated and D, deleterious.\na Amino acid change, first residue listed corresponds to the CAST allele and second corresponds to the B6 allele.\nb Indicates which allele was designated as \"mutant\", i.e. B6/CAST, B6 allele is mutant and CAST is wild 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