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of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9. The HG8 donor region promotes leanness. Congenic females displayed a reduction of over 25% in AI. In contrast, the HG9 strain is an obese mouse model. The strain is quite novel for two reasons. First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males. Secondly, it is dependent on hg for its expression. The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh. Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T17585","span":{"begin":64,"end":78},"obj":"UBERON:0001013"},{"id":"T17586","span":{"begin":142,"end":149},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T17587","span":{"begin":231,"end":236},"obj":"NCBITaxon:10088"},{"id":"T17588","span":{"begin":345,"end":352},"obj":"PATO_UBERON_EXT:female_or_bearer_of_femaleness"},{"id":"T17589","span":{"begin":371,"end":376},"obj":"PATO_UBERON_EXT:male_or_bearer_of_maleness"},{"id":"T17590","span":{"begin":418,"end":428},"obj":"GO:0010467"},{"id":"T17591","span":{"begin":486,"end":491},"obj":"NCBITaxon:10088"},{"id":"T17592","span":{"begin":571,"end":581},"obj":"GO:0065007"},{"id":"T17593","span":{"begin":585,"end":599},"obj":"UBERON:0001013"},{"id":"T17594","span":{"begin":614,"end":616},"obj":"CHEBI_GO_PR_EXT:growth_hormone"},{"id":"T17595","span":{"begin":675,"end":683},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T17596","span":{"begin":787,"end":800},"obj":"GO_PATO_EXT:physiological_process_or_quality"},{"id":"T17597","span":{"begin":837,"end":841},"obj":"CHEBI_EXT:33290"},{"id":"T17598","span":{"begin":837,"end":848},"obj":"GO:0007631"},{"id":"T17599","span":{"begin":853,"end":860},"obj":"PR_EXT:000045358"}],"text":"Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9. The HG8 donor region promotes leanness. Congenic females displayed a reduction of over 25% in AI. In contrast, the HG9 strain is an obese mouse model. The strain is quite novel for two reasons. First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males. Secondly, it is dependent on hg for its expression. The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh. Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T17395","span":{"begin":64,"end":78},"obj":"UBERON:0001013"},{"id":"T17396","span":{"begin":231,"end":236},"obj":"NCBITaxon:10088"},{"id":"T17397","span":{"begin":418,"end":428},"obj":"GO:0010467"},{"id":"T17398","span":{"begin":486,"end":491},"obj":"NCBITaxon:10088"},{"id":"T17399","span":{"begin":571,"end":581},"obj":"GO:0065007"},{"id":"T17400","span":{"begin":585,"end":599},"obj":"UBERON:0001013"},{"id":"T17401","span":{"begin":837,"end":841},"obj":"CHEBI:33290"},{"id":"T17402","span":{"begin":837,"end":848},"obj":"GO:0007631"},{"id":"T17403","span":{"begin":853,"end":860},"obj":"PR:000045358"}],"text":"Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9. The HG8 donor region promotes leanness. Congenic females displayed a reduction of over 25% in AI. In contrast, the HG9 strain is an obese mouse model. The strain is quite novel for two reasons. First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males. Secondly, it is dependent on hg for its expression. The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh. Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity."}