PMC:1472690 / 725-1114
Annnotations
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T311","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T312","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T313","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T314","span":{"begin":333,"end":335},"obj":"Protein"},{"id":"T307","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T308","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T309","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T310","span":{"begin":79,"end":91},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T440","span":{"begin":79,"end":91},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T441","span":{"begin":189,"end":193},"obj":"http://www.uniprot.org/uniprot/P10145"},{"id":"T442","span":{"begin":279,"end":283},"obj":"http://www.uniprot.org/uniprot/P10145"},{"id":"T427","span":{"begin":46,"end":50},"obj":"http://www.uniprot.org/uniprot/P05231"},{"id":"T430","span":{"begin":39,"end":44},"obj":"http://www.uniprot.org/uniprot/P01584"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T214","span":{"begin":58,"end":66},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T215","span":{"begin":58,"end":66},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T216","span":{"begin":58,"end":66},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T217","span":{"begin":58,"end":66},"obj":"http://purl.obolibrary.org/obo/GO_0070265"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T338","span":{"begin":236,"end":243},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T343","span":{"begin":46,"end":50},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T350","span":{"begin":79,"end":91},"obj":"http://purl.obolibrary.org/obo/GO_0005133"},{"id":"T351","span":{"begin":189,"end":193},"obj":"http://purl.obolibrary.org/obo/GO_0005153"},{"id":"T352","span":{"begin":279,"end":283},"obj":"http://purl.obolibrary.org/obo/GO_0005153"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
sentences
{"project":"sentences","denotations":[{"id":"T194","span":{"begin":121,"end":208},"obj":"Sentence"},{"id":"T195","span":{"begin":209,"end":293},"obj":"Sentence"},{"id":"T196","span":{"begin":294,"end":362},"obj":"Sentence"},{"id":"T8","span":{"begin":121,"end":208},"obj":"Sentence"},{"id":"T9","span":{"begin":209,"end":293},"obj":"Sentence"},{"id":"T10","span":{"begin":294,"end":362},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
simple1
{"project":"simple1","denotations":[{"id":"T400","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T401","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T402","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T403","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T404","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T405","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T406","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T407","span":{"begin":333,"end":335},"obj":"Protein"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T860","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T862","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T863","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T864","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T865","span":{"begin":337,"end":347},"obj":"Gene_expression"},{"id":"T866","span":{"begin":297,"end":305},"obj":"Positive_regulation"},{"id":"T829","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T830","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T831","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T835","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T836","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T837","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T838","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T839","span":{"begin":333,"end":335},"obj":"Protein"}],"relations":[{"id":"R211","pred":"themeOf","subj":"T860","obj":"T862"},{"id":"R212","pred":"themeOf","subj":"T860","obj":"T862"},{"id":"R213","pred":"themeOf","subj":"T860","obj":"T862"},{"id":"R214","pred":"themeOf","subj":"T860","obj":"T862"},{"id":"R215","pred":"themeOf","subj":"T865","obj":"T866"},{"id":"R216","pred":"themeOf","subj":"T865","obj":"T866"},{"id":"R338","pred":"themeOf","subj":"T829","obj":"T860"},{"id":"R339","pred":"themeOf","subj":"T830","obj":"T860"},{"id":"R340","pred":"themeOf","subj":"T831","obj":"T860"},{"id":"R343","pred":"themeOf","subj":"T835","obj":"T860"},{"id":"R344","pred":"themeOf","subj":"T836","obj":"T864"},{"id":"R345","pred":"themeOf","subj":"T837","obj":"T863"},{"id":"R346","pred":"themeOf","subj":"T838","obj":"T865"},{"id":"R347","pred":"themeOf","subj":"T839","obj":"T865"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T486","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T487","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T489","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T490","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T491","span":{"begin":337,"end":347},"obj":"Gene_expression"},{"id":"T492","span":{"begin":297,"end":305},"obj":"Positive_regulation"},{"id":"T455","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T456","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T457","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T461","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T462","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T463","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T464","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T465","span":{"begin":333,"end":335},"obj":"Protein"}],"relations":[{"id":"R123","pred":"themeOf","subj":"T487","obj":"T486"},{"id":"R124","pred":"themeOf","subj":"T487","obj":"T486"},{"id":"R125","pred":"themeOf","subj":"T487","obj":"T486"},{"id":"R126","pred":"themeOf","subj":"T487","obj":"T486"},{"id":"R127","pred":"themeOf","subj":"T491","obj":"T492"},{"id":"R128","pred":"themeOf","subj":"T491","obj":"T492"},{"id":"R246","pred":"themeOf","subj":"T455","obj":"T487"},{"id":"R247","pred":"themeOf","subj":"T456","obj":"T487"},{"id":"R248","pred":"themeOf","subj":"T457","obj":"T487"},{"id":"R249","pred":"themeOf","subj":"T457","obj":"T486"},{"id":"R252","pred":"themeOf","subj":"T461","obj":"T487"},{"id":"R253","pred":"themeOf","subj":"T461","obj":"T486"},{"id":"R254","pred":"themeOf","subj":"T462","obj":"T489"},{"id":"R255","pred":"themeOf","subj":"T463","obj":"T490"},{"id":"R256","pred":"themeOf","subj":"T464","obj":"T491"},{"id":"R257","pred":"themeOf","subj":"T465","obj":"T491"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T607","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T608","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T609","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T610","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T611","span":{"begin":337,"end":347},"obj":"Gene_expression"},{"id":"T612","span":{"begin":297,"end":305},"obj":"Positive_regulation"},{"id":"T575","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T576","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T577","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T581","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T582","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T583","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T584","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T585","span":{"begin":333,"end":335},"obj":"Protein"}],"relations":[{"id":"R146","pred":"themeOf","subj":"T610","obj":"T609"},{"id":"R148","pred":"themeOf","subj":"T611","obj":"T612"},{"id":"R307","pred":"themeOf","subj":"T585","obj":"T611"},{"id":"R142","pred":"themeOf","subj":"T607","obj":"T608"},{"id":"R143","pred":"themeOf","subj":"T607","obj":"T608"},{"id":"R144","pred":"themeOf","subj":"T607","obj":"T608"},{"id":"R145","pred":"themeOf","subj":"T607","obj":"T608"},{"id":"R147","pred":"themeOf","subj":"T611","obj":"T612"},{"id":"R298","pred":"themeOf","subj":"T575","obj":"T607"},{"id":"R299","pred":"themeOf","subj":"T576","obj":"T607"},{"id":"R300","pred":"themeOf","subj":"T577","obj":"T607"},{"id":"R302","pred":"themeOf","subj":"T581","obj":"T607"},{"id":"R303","pred":"themeOf","subj":"T582","obj":"T609"},{"id":"R304","pred":"themeOf","subj":"T582","obj":"T610"},{"id":"R305","pred":"themeOf","subj":"T583","obj":"T610"},{"id":"R306","pred":"themeOf","subj":"T584","obj":"T611"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T764","span":{"begin":252,"end":292},"obj":"Entity"},{"id":"T772","span":{"begin":186,"end":193},"obj":"Protein"},{"id":"T773","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T786","span":{"begin":275,"end":292},"obj":"Entity"},{"id":"T787","span":{"begin":379,"end":385},"obj":"Entity"},{"id":"T789","span":{"begin":79,"end":119},"obj":"Protein"},{"id":"T793","span":{"begin":322,"end":336},"obj":"Entity"},{"id":"T798","span":{"begin":121,"end":127},"obj":"Entity"},{"id":"T799","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T802","span":{"begin":306,"end":347},"obj":"Protein"},{"id":"T809","span":{"begin":309,"end":313},"obj":"Protein"},{"id":"T812","span":{"begin":79,"end":119},"obj":"Gene_expression"},{"id":"T813","span":{"begin":79,"end":119},"obj":"Positive_regulation"},{"id":"T730","span":{"begin":121,"end":156},"obj":"Entity"},{"id":"T731","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T735","span":{"begin":333,"end":335},"obj":"Protein"},{"id":"T739","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T743","span":{"begin":128,"end":145},"obj":"Entity"},{"id":"T744","span":{"begin":360,"end":361},"obj":"Entity"},{"id":"T749","span":{"begin":100,"end":119},"obj":"Entity"},{"id":"T750","span":{"begin":206,"end":207},"obj":"Entity"},{"id":"T753","span":{"begin":103,"end":109},"obj":"Entity"},{"id":"T754","span":{"begin":244,"end":251},"obj":"Protein"},{"id":"T821","span":{"begin":294,"end":347},"obj":"Positive_regulation"},{"id":"T822","span":{"begin":236,"end":292},"obj":"Binding"}],"relations":[{"id":"R199","pred":"partOf","subj":"T786","obj":"T799"},{"id":"R200","pred":"themeOf","subj":"T789","obj":"T812"},{"id":"R201","pred":"themeOf","subj":"T789","obj":"T813"},{"id":"R332","pred":"causeOf","subj":"T749","obj":"T813"},{"id":"R333","pred":"themeOf","subj":"T754","obj":"T822"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T518","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T519","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T520","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T517","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T524","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T525","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T526","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T527","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T528","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T529","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T530","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T531","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T532","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T533","span":{"begin":247,"end":251},"obj":"Protein"},{"id":"T534","span":{"begin":279,"end":292},"obj":"Protein"},{"id":"T535","span":{"begin":179,"end":185},"obj":"Gene_expression"},{"id":"T536","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T537","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T538","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T539","span":{"begin":309,"end":321},"obj":"Protein"}],"relations":[{"id":"R266","pred":"themeOf","subj":"T517","obj":"T524"},{"id":"R267","pred":"themeOf","subj":"T518","obj":"T525"},{"id":"R268","pred":"themeOf","subj":"T519","obj":"T526"},{"id":"R269","pred":"themeOf","subj":"T520","obj":"T527"},{"id":"R270","pred":"themeOf","subj":"T524","obj":"T528"},{"id":"R271","pred":"themeOf","subj":"T525","obj":"T529"},{"id":"R272","pred":"themeOf","subj":"T526","obj":"T530"},{"id":"R273","pred":"themeOf","subj":"T527","obj":"T531"},{"id":"R274","pred":"themeOf","subj":"T532","obj":"T535"},{"id":"R275","pred":"themeOf","subj":"T532","obj":"T536"},{"id":"R276","pred":"themeOf","subj":"T533","obj":"T536"},{"id":"R277","pred":"themeOf","subj":"T533","obj":"T537"},{"id":"R278","pred":"themeOf","subj":"T534","obj":"T537"},{"id":"R279","pred":"themeOf","subj":"T535","obj":"T538"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
testone
{"project":"testone","denotations":[{"id":"T43","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T44","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T45","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T46","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T47","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T48","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T49","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T50","span":{"begin":333,"end":335},"obj":"Protein"},{"id":"T71","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T72","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T73","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T74","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T75","span":{"begin":284,"end":292},"obj":"Entity"},{"id":"T76","span":{"begin":297,"end":305},"obj":"Positive_regulation"},{"id":"T77","span":{"begin":322,"end":332},"obj":"Negative_regulation"},{"id":"T78","span":{"begin":337,"end":347},"obj":"Gene_expression"}],"relations":[{"id":"R2","pred":"themeOf","subj":"T43","obj":"T71"},{"id":"R3","pred":"themeOf","subj":"T44","obj":"T71"},{"id":"R5","pred":"themeOf","subj":"T46","obj":"T71"},{"id":"R6","pred":"themeOf","subj":"T49","obj":"T78"},{"id":"R7","pred":"equivalentTo","subj":"T50","obj":"T49"},{"id":"R22","pred":"themeOf","subj":"T71","obj":"T72"},{"id":"R23","pred":"themeOf","subj":"T75","obj":"T74"},{"id":"R24","pred":"partOf","subj":"T75","obj":"T48"},{"id":"R25","pred":"themeOf","subj":"T77","obj":"T76"},{"id":"R26","pred":"themeOf","subj":"T78","obj":"T76"},{"id":"R4","pred":"themeOf","subj":"T45","obj":"T71"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}
test3
{"project":"test3","denotations":[{"id":"T104","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T105","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T106","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T107","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T108","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T109","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T110","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T111","span":{"begin":333,"end":335},"obj":"Protein"},{"id":"T141","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T142","span":{"begin":39,"end":44},"obj":"Protein"},{"id":"T143","span":{"begin":46,"end":50},"obj":"Protein"},{"id":"T144","span":{"begin":52,"end":75},"obj":"Protein"},{"id":"T145","span":{"begin":79,"end":91},"obj":"Protein"},{"id":"T146","span":{"begin":92,"end":99},"obj":"Positive_regulation"},{"id":"T147","span":{"begin":157,"end":164},"obj":"Positive_regulation"},{"id":"T148","span":{"begin":189,"end":193},"obj":"Protein"},{"id":"T149","span":{"begin":236,"end":243},"obj":"Binding"},{"id":"T150","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T151","span":{"begin":297,"end":305},"obj":"Positive_regulation"},{"id":"T152","span":{"begin":309,"end":332},"obj":"Protein"},{"id":"T153","span":{"begin":333,"end":335},"obj":"Protein"},{"id":"T154","span":{"begin":337,"end":347},"obj":"Gene_expression"}],"relations":[{"id":"R45","pred":"themeOf","subj":"T141","obj":"T146"},{"id":"R46","pred":"themeOf","subj":"T142","obj":"T141"},{"id":"R47","pred":"themeOf","subj":"T143","obj":"T141"},{"id":"R48","pred":"themeOf","subj":"T144","obj":"T141"},{"id":"R49","pred":"themeOf","subj":"T145","obj":"T141"},{"id":"R50","pred":"themeOf","subj":"T148","obj":"T149"},{"id":"R51","pred":"themeOf","subj":"T148","obj":"T147"},{"id":"R52","pred":"themeOf","subj":"T152","obj":"T154"},{"id":"R53","pred":"equivalentTo","subj":"T153","obj":"T152"},{"id":"R54","pred":"themeOf","subj":"T154","obj":"T151"}],"text":" observed no significant production of IL-1β, IL-6, tumor necrosis factor α or interferon γ induced by glucan phosphate. Glucan phosphate-treated leukocytes induced a substantial amount of IL-8 (peak at 18 h: 5000 pg/ml), likely due to binding of NFκB to a consensus site in the IL-8 promoter. An increase in IL-1receptor antagonist(RA) production (peak at 24 h: 12000 pg/ml) by glucan pho"}