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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1459172","sourcedb":"PMC","sourceid":"1459172","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1459172","text":"Intermolecular binding of RNA molecules is important in a broad spectrum of cases, ranging from mRNA accessibility to siRNA or miRNA binding, RNA probe design, or designing RNA openers [50]. An important question that arises repeatedly is to explain differences in RNA-RNA binding between seemingly very similar or even identical binding sites. As demonstrated e.g. in [22,29,51,52], different RNA secondary structure of the target molecule can have dramatic effects on binding affinities even if the sequence of the binding site is identical.","tracks":[{"project":"2_test","denotations":[{"id":"16722605-15716109-1692569","span":{"begin":186,"end":188},"obj":"15716109"},{"id":"16722605-15457527-1692570","span":{"begin":370,"end":372},"obj":"15457527"},{"id":"16722605-11222752-1692571","span":{"begin":376,"end":378},"obj":"11222752"}],"attributes":[{"subj":"16722605-15716109-1692569","pred":"source","obj":"2_test"},{"subj":"16722605-15457527-1692570","pred":"source","obj":"2_test"},{"subj":"16722605-11222752-1692571","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#daec93","default":true}]}]}}