PMC:1459172 / 28681-29224 JSONTXT

{"project":"2_test","denotations":[{"id":"16722605-15716109-1692569","span":{"begin":186,"end":188},"obj":"15716109"},{"id":"16722605-15457527-1692570","span":{"begin":370,"end":372},"obj":"15457527"},{"id":"16722605-11222752-1692571","span":{"begin":376,"end":378},"obj":"11222752"}],"text":"Intermolecular binding of RNA molecules is important in a broad spectrum of cases, ranging from mRNA accessibility to siRNA or miRNA binding, RNA probe design, or designing RNA openers [50]. An important question that arises repeatedly is to explain differences in RNA-RNA binding between seemingly very similar or even identical binding sites. As demonstrated e.g. in [22,29,51,52], different RNA secondary structure of the target molecule can have dramatic effects on binding affinities even if the sequence of the binding site is identical."}