PMC:1448208 / 28996-29641 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T24960","span":{"begin":241,"end":242},"obj":"."},{"id":"T24959","span":{"begin":238,"end":241},"obj":"NN"},{"id":"T24958","span":{"begin":236,"end":237},"obj":"SYM"},{"id":"T24957","span":{"begin":235,"end":236},"obj":"HYPH"},{"id":"T24956","span":{"begin":234,"end":235},"obj":"SYM"},{"id":"T24955","span":{"begin":229,"end":233},"obj":"NN"},{"id":"T24954","span":{"begin":225,"end":228},"obj":"VBP"},{"id":"T24953","span":{"begin":218,"end":224},"obj":"NNS"},{"id":"T24952","span":{"begin":214,"end":217},"obj":"DT"},{"id":"T24951","span":{"begin":213,"end":242},"obj":"sentence"},{"id":"T24950","span":{"begin":212,"end":213},"obj":"."},{"id":"T24949","span":{"begin":209,"end":212},"obj":"NN"},{"id":"T24948","span":{"begin":206,"end":208},"obj":"IN"},{"id":"T24947","span":{"begin":200,"end":205},"obj":"NNS"},{"id":"T24946","span":{"begin":197,"end":198},"obj":"SYM"},{"id":"T24945","span":{"begin":198,"end":199},"obj":"CD"},{"id":"T24944","span":{"begin":196,"end":197},"obj":"CD"},{"id":"T24943","span":{"begin":191,"end":195},"obj":"VBD"},{"id":"T24942","span":{"begin":186,"end":190},"obj":"WDT"},{"id":"T24941","span":{"begin":181,"end":185},"obj":"NNS"},{"id":"T24940","span":{"begin":176,"end":180},"obj":"IN"},{"id":"T24939","span":{"begin":161,"end":165},"obj":"VBD"},{"id":"T24938","span":{"begin":166,"end":175},"obj":"VBN"},{"id":"T24937","span":{"begin":153,"end":160},"obj":"NNS"},{"id":"T24936","span":{"begin":152,"end":213},"obj":"sentence"},{"id":"T24935","span":{"begin":151,"end":152},"obj":"."},{"id":"T24934","span":{"begin":134,"end":138},"obj":"NN"},{"id":"T24933","span":{"begin":139,"end":151},"obj":"NN"},{"id":"T24932","span":{"begin":127,"end":133},"obj":"JJ"},{"id":"T24931","span":{"begin":124,"end":126},"obj":"IN"},{"id":"T24930","span":{"begin":113,"end":123},"obj":"VBN"},{"id":"T24929","span":{"begin":110,"end":112},"obj":"IN"},{"id":"T24928","span":{"begin":101,"end":109},"obj":"NNS"},{"id":"T24927","span":{"begin":90,"end":100},"obj":"NN"},{"id":"T24926","span":{"begin":86,"end":89},"obj":"CC"},{"id":"T24925","span":{"begin":75,"end":79},"obj":"NN"},{"id":"T24924","span":{"begin":62,"end":74},"obj":"JJ"},{"id":"T24923","span":{"begin":80,"end":85},"obj":"NN"},{"id":"T24922","span":{"begin":58,"end":61},"obj":"DT"},{"id":"T24921","span":{"begin":55,"end":57},"obj":"IN"},{"id":"T24920","span":{"begin":43,"end":47},"obj":"NN"},{"id":"T24919","span":{"begin":37,"end":42},"obj":"NN"},{"id":"T24918","span":{"begin":31,"end":36},"obj":"NN"},{"id":"T24917","span":{"begin":48,"end":54},"obj":"NNS"},{"id":"T24916","span":{"begin":20,"end":30},"obj":"JJ"},{"id":"T24915","span":{"begin":17,"end":19},"obj":"IN"},{"id":"T24914","span":{"begin":9,"end":16},"obj":"NN"}],"relations":[{"id":"R7247","pred":"prep","subj":"T24915","obj":"T24914"},{"id":"R7248","pred":"amod","subj":"T24916","obj":"T24917"},{"id":"R7249","pred":"pobj","subj":"T24917","obj":"T24915"},{"id":"R7250","pred":"compound","subj":"T24918","obj":"T24917"},{"id":"R7251","pred":"compound","subj":"T24919","obj":"T24920"},{"id":"R7252","pred":"compound","subj":"T24920","obj":"T24917"},{"id":"R7253","pred":"prep","subj":"T24921","obj":"T24917"},{"id":"R7254","pred":"det","subj":"T24922","obj":"T24923"},{"id":"R7255","pred":"pobj","subj":"T24923","obj":"T24921"},{"id":"R7256","pred":"amod","subj":"T24924","obj":"T24923"},{"id":"R7257","pred":"compound","subj":"T24925","obj":"T24923"},{"id":"R7258","pred":"cc","subj":"T24926","obj":"T24923"},{"id":"R7259","pred":"compound","subj":"T24927","obj":"T24928"},{"id":"R7260","pred":"conj","subj":"T24928","obj":"T24923"},{"id":"R7261","pred":"mark","subj":"T24929","obj":"T24930"},{"id":"R7262","pred":"advcl","subj":"T24930","obj":"T24917"},{"id":"R7263","pred":"prep","subj":"T24931","obj":"T24930"},{"id":"R7264","pred":"amod","subj":"T24932","obj":"T24933"},{"id":"R7265","pred":"pobj","subj":"T24933","obj":"T24931"},{"id":"R7266","pred":"compound","subj":"T24934","obj":"T24933"},{"id":"R7267","pred":"punct","subj":"T24935","obj":"T24914"},{"id":"R7268","pred":"nsubjpass","subj":"T24937","obj":"T24938"},{"id":"R7269","pred":"auxpass","subj":"T24939","obj":"T24938"},{"id":"R7270","pred":"prep","subj":"T24940","obj":"T24938"},{"id":"R7271","pred":"pobj","subj":"T24941","obj":"T24940"},{"id":"R7272","pred":"dep","subj":"T24942","obj":"T24943"},{"id":"R7273","pred":"relcl","subj":"T24943","obj":"T24941"},{"id":"R7274","pred":"quantmod","subj":"T24944","obj":"T24945"},{"id":"R7275","pred":"nummod","subj":"T24945","obj":"T24947"},{"id":"R7276","pred":"punct","subj":"T24946","obj":"T24945"},{"id":"R7277","pred":"attr","subj":"T24947","obj":"T24943"},{"id":"R7278","pred":"prep","subj":"T24948","obj":"T24947"},{"id":"R7279","pred":"pobj","subj":"T24949","obj":"T24948"},{"id":"R7280","pred":"punct","subj":"T24950","obj":"T24938"},{"id":"R7281","pred":"det","subj":"T24952","obj":"T24953"},{"id":"R7282","pred":"nsubj","subj":"T24953","obj":"T24954"},{"id":"R7283","pred":"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2 Summary of additional blood amino acid levels in the intermediate MSUD model and littermate controls as determined by tandem mass spectrometry. Samples were collected from mice that were 4–6 weeks of age. All values are mean +/- SEM.\nMSUD Genotype Alanine Glutamate Glutamine\n(μmole/L)\ncontrol 225.2 ± 36.6 (11) 106.5 ± 10.5 (11) 67.8 ± 7.6 (11)\n525A 175.0 ± 28.7 (10) 68.4 ± 7.7** (10) 58.0 ± 7.0 (10)\nA 144.1 ± 16.9* (10) 65.9 ± 8.9** (10) 37.7 ± 6.5**,*** (10)\n*: Significantly different from control (P \u003c 0.05).\n**: Significantly different from control (P \u003c 0.01).\n***: Significantly different from Line 525A (P \u003c 0.05)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T24913","span":{"begin":181,"end":185},"obj":"NCBITaxon:10088"},{"id":"T24912","span":{"begin":37,"end":47},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T24911","span":{"begin":31,"end":36},"obj":"UBERON:0000178"}],"text":"Table 2 Summary of additional blood amino acid levels in the intermediate MSUD model and littermate controls as determined by tandem mass spectrometry. Samples were collected from mice that were 4–6 weeks of age. All values are mean +/- SEM.\nMSUD Genotype Alanine Glutamate Glutamine\n(μmole/L)\ncontrol 225.2 ± 36.6 (11) 106.5 ± 10.5 (11) 67.8 ± 7.6 (11)\n525A 175.0 ± 28.7 (10) 68.4 ± 7.7** (10) 58.0 ± 7.0 (10)\nA 144.1 ± 16.9* (10) 65.9 ± 8.9** (10) 37.7 ± 6.5**,*** (10)\n*: Significantly different from control (P \u003c 0.05).\n**: Significantly different from control (P \u003c 0.01).\n***: Significantly different from Line 525A (P \u003c 0.05)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T24910","span":{"begin":181,"end":185},"obj":"NCBITaxon:10088"},{"id":"T24909","span":{"begin":31,"end":36},"obj":"UBERON:0000178"}],"text":"Table 2 Summary of additional blood amino acid levels in the intermediate MSUD model and littermate controls as determined by tandem mass spectrometry. Samples were collected from mice that were 4–6 weeks of age. All values are mean +/- SEM.\nMSUD Genotype Alanine Glutamate Glutamine\n(μmole/L)\ncontrol 225.2 ± 36.6 (11) 106.5 ± 10.5 (11) 67.8 ± 7.6 (11)\n525A 175.0 ± 28.7 (10) 68.4 ± 7.7** (10) 58.0 ± 7.0 (10)\nA 144.1 ± 16.9* (10) 65.9 ± 8.9** (10) 37.7 ± 6.5**,*** (10)\n*: Significantly different from control (P \u003c 0.05).\n**: Significantly different from control (P \u003c 0.01).\n***: Significantly different from Line 525A (P \u003c 0.05)."}