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PMC:1448208 / 25124-25985 JSONTXT

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Id Subject Object Predicate Lexical cue
T16088 860-861 . denotes .
T16087 859-860 -RRB- denotes )
T16086 850-853 RB denotes not
T16085 845-849 NNS denotes data
T16084 854-859 VBN denotes shown
T16083 844-845 -LRB- denotes (
T16082 840-843 NN denotes DNA
T16081 835-839 NN denotes tail
T16080 832-834 IN denotes of
T16079 823-831 NN denotes analysis
T16078 818-822 NN denotes blot
T16077 809-817 NNP denotes Southern
T16076 806-808 IN denotes by
T16075 797-805 VBN denotes compared
T16074 794-796 IN denotes as
T16073 782-786 NN denotes copy
T16072 787-793 NN denotes number
T16071 772-781 NN denotes transgene
T16070 769-771 IN denotes in
T16069 755-768 RB denotes substantially
T16068 746-754 VBD denotes differed
T16067 740-745 NNS denotes lines
T16066 734-739 DT denotes These
T16065 733-861 sentence denotes These lines differed substantially in transgene copy number as compared by Southern blot analysis of tail DNA (data not shown).
T16064 732-733 . denotes .
T16063 727-732 NNS denotes lines
T16062 721-726 DT denotes these
T16061 718-720 IN denotes of
T16060 716-717 CD denotes 9
T16059 713-715 IN denotes of
T16058 707-712 NN denotes total
T16057 705-706 DT denotes a
T16056 702-704 IN denotes on
T16055 691-695 RB denotes only
T16054 688-690 TO denotes to
T16053 696-701 VB denotes focus
T16052 685-687 PRP denotes us
T16051 677-684 VBD denotes allowed
T16050 667-676 NNS denotes resources
T16049 659-666 VBN denotes Limited
T16048 658-733 sentence denotes Limited resources allowed us to only focus on a total of 9 of these lines.
T16047 657-658 . denotes .
T16046 649-657 NNS denotes founders
T16045 643-648 DT denotes these
T16044 638-642 IN denotes from
T16043 621-631 JJ denotes transgenic
T16042 611-620 JJ denotes different
T16041 632-637 NNS denotes lines
T16040 608-610 CD denotes 15
T16039 605-607 IN denotes of
T16038 599-604 NN denotes total
T16037 597-598 DT denotes a
T16036 585-596 VBD denotes established
T16035 582-584 PRP denotes We
T16034 581-658 sentence denotes We established a total of 15 different transgenic lines from these founders.
T16033 580-581 . denotes .
T16032 570-580 VBD denotes segregated
T16031 565-569 WDT denotes that
T16030 549-558 NN denotes insertion
T16029 539-548 NN denotes transgene
T16028 559-564 NNS denotes sites
T16027 530-538 JJ denotes multiple
T16026 518-525 NNS denotes animals
T16025 514-517 DT denotes the
T16024 511-513 IN denotes of
T16023 506-510 JJ denotes many
T16022 526-529 VBD denotes had
T16021 501-505 IN denotes that
T16020 483-491 NNS denotes founders
T16019 477-482 DT denotes these
T16018 474-476 IN denotes of
T16017 492-500 VBD denotes revealed
T16016 465-473 NN denotes breeding
T16015 454-464 JJ denotes Subsequent
T16014 453-581 sentence denotes Subsequent breeding of these founders revealed that many of the animals had multiple transgene insertion sites that segregated.
T16013 452-453 . denotes .
T16012 435-443 JJ denotes positive
T16011 425-434 NN denotes transgene
T16010 444-452 NNS denotes founders
T16009 423-424 CD denotes 8
T16008 411-413 PRP denotes we
T16007 409-411 , denotes ,
T16006 399-409 NNP denotes Cincinnati
T16005 396-398 IN denotes of
T16004 385-395 NNP denotes University
T16003 381-384 DT denotes the
T16002 378-380 IN denotes at
T16001 367-377 NNS denotes injections
T16000 363-366 DT denotes the
T15999 414-422 VBD denotes obtained
T15998 358-362 IN denotes From
T15997 357-453 sentence denotes From the injections at the University of Cincinnati, we obtained 8 transgene positive founders.
T15996 356-357 . denotes .
T15995 355-356 -RRB- denotes )
T15994 354-355 NN denotes D
T15993 352-353 CC denotes &
T15992 350-352 , denotes ,
T15991 349-350 NN denotes B
T15990 347-349 , denotes ,
T15989 340-345 NNS denotes Lines
T15988 346-347 NN denotes A
T15987 339-340 -LRB- denotes (
T15986 322-332 JJ denotes transgenic
T15985 312-321 JJ denotes different
T15984 333-338 NNS denotes lines
T15983 310-311 CD denotes 3
T15982 307-309 IN denotes of
T15981 296-306 NN denotes generation
T15980 292-295 DT denotes the
T15979 289-291 IN denotes to
T15978 285-288 VBD denotes led
T15977 280-284 WDT denotes that
T15976 264-268 VBD denotes were
T15975 246-254 JJ denotes positive
T15974 236-245 NN denotes transgene
T15973 255-263 NNS denotes founders
T15972 234-235 CD denotes 2
T15971 232-234 , denotes ,
T15970 222-232 NNP denotes Pittsburgh
T15969 219-221 IN denotes of
T15968 208-218 NNP denotes University
T15967 204-207 DT denotes the
T15966 201-203 IN denotes at
T15965 190-200 NNS denotes injections
T15964 269-279 VBN denotes identified
T15963 185-189 IN denotes From
T15962 184-357 sentence denotes From injections at the University of Pittsburgh, 2 transgene positive founders were identified that led to the generation of 3 different transgenic lines (Lines A, B, & D).
T15961 183-184 . denotes .
T15960 170-171 HYPH denotes -
T15938 59-62 DT denotes the
T15937 56-58 IN denotes by
T15936 52-55 VBN denotes zed
T15935 51-52 NNS denotes i
T15934 51-86 sentence denotes ized by the Bujard laboratory [34].
T15900 8-12 NNS denotes mice
T15899 3-4 HYPH denotes -
T15898 4-7 NN denotes tTA
T15897 0-3 NN denotes LAP
T15896 0-13 sentence denotes LAP-tTA mice
T15911 24-25 NN denotes u
T15910 23-24 VB denotes o
T15909 23-29 sentence denotes ously
T15908 22-23 JJ denotes i
T15907 21-22 NN denotes v
T15906 18-21 NN denotes pre
T15905 18-23 sentence denotes previ
T15904 15-17 VB denotes re
T15903 13-14 VBD denotes w
T15902 14-15 VBN denotes e
T15901 13-18 sentence denotes were
T15917 32-33 NN denotes d
T15916 29-32 NN denotes pro
T15915 29-36 sentence denotes produce
T15914 27-28 JJ denotes y
T15913 26-27 JJ denotes l
T15912 25-26 NNS denotes s
T15959 171-173 NN denotes E2
T15958 167-170 NN denotes TRE
T15957 174-183 NN denotes transgene
T15956 163-166 DT denotes the
T15955 154-162 VBD denotes harbored
T15954 149-153 WDT denotes that
T15953 144-148 NNS denotes mice
T15952 133-143 JJ denotes transgenic
T15951 125-132 VB denotes produce
T15950 122-124 TO denotes to
T15949 113-116 VBD denotes was
T15948 117-121 VBN denotes used
T15947 98-112 NN denotes microinjection
T15946 87-97 JJ denotes Pronuclear
T15945 86-184 sentence denotes Pronuclear microinjection was used to produce transgenic mice that harbored the TRE-E2 transgene.
T15944 85-86 . denotes .
T15943 84-85 -RRB- denotes ]
T15942 82-84 CD denotes 34
T15941 81-82 -LRB- denotes [
T15940 63-69 NNP denotes Bujard
T15939 70-80 NN denotes laboratory
T15933 49-50 VB denotes e
T15932 48-49 TO denotes t
T15931 47-48 DT denotes c
T15930 46-47 VBN denotes a
T15929 45-46 NN denotes r
T15928 50-51 VBN denotes r
T15927 44-45 DT denotes a
T15926 44-51 sentence denotes aracter
T15925 43-44 DT denotes h
T15924 42-43 NN denotes c
T15923 38-41 CC denotes and
T15922 36-37 NN denotes d
T15921 36-44 sentence denotes d and ch
T15920 35-36 NNS denotes e
T15919 34-35 JJ denotes c
T15918 33-34 JJ denotes u
R4008 T15941 T15942 punct [,34
R4009 T15942 T15936 parataxis 34,zed
R4010 T15943 T15942 punct ],34
R4011 T15946 T15947 amod Pronuclear,microinjection
R4012 T15947 T15948 nsubjpass microinjection,used
R4013 T15949 T15948 auxpass was,used
R4014 T15950 T15951 aux to,produce
R4015 T15951 T15948 advcl produce,used
R4016 T15952 T15953 amod transgenic,mice
R4017 T15953 T15951 dobj mice,produce
R4018 T15954 T15955 dep that,harbored
R4019 T15955 T15953 relcl harbored,mice
R4020 T15956 T15957 det the,transgene
R4021 T15957 T15955 dobj transgene,harbored
R4022 T15958 T15959 compound TRE,E2
R4023 T15959 T15957 compound E2,transgene
R4024 T15960 T15959 punct -,E2
R4025 T15961 T15948 punct .,used
R4026 T15963 T15964 prep From,identified
R4027 T15965 T15963 pobj injections,From
R4028 T15966 T15965 prep at,injections
R4029 T15967 T15968 det the,University
R4030 T15968 T15966 pobj University,at
R4031 T15969 T15968 prep of,University
R4032 T15970 T15969 pobj Pittsburgh,of
R4033 T15971 T15964 punct ", ",identified
R4034 T15972 T15973 nummod 2,founders
R4035 T15973 T15964 nsubjpass founders,identified
R4036 T15974 T15975 npadvmod transgene,positive
R4037 T15975 T15973 amod positive,founders
R4038 T15976 T15964 auxpass were,identified
R4039 T15977 T15978 dep that,led
R4040 T15978 T15964 ccomp led,identified
R4041 T15979 T15978 prep to,led
R4042 T15980 T15981 det the,generation
R4043 T15981 T15979 pobj generation,to
R4044 T15982 T15981 prep of,generation
R4045 T15983 T15984 nummod 3,lines
R4046 T15984 T15982 pobj lines,of
R4047 T15985 T15984 amod different,lines
R4048 T15986 T15984 amod transgenic,lines
R4049 T15987 T15988 punct (,A
R4050 T15988 T15984 parataxis A,lines
R4051 T15989 T15988 compound Lines,A
R4052 T15990 T15988 punct ", ",A
R4053 T15991 T15988 conj B,A
R4054 T15992 T15991 punct ", ",B
R4055 T15993 T15991 cc &,B
R4056 T15994 T15991 conj D,B
R4057 T15995 T15988 punct ),A
R4058 T15996 T15964 punct .,identified
R4059 T15998 T15999 prep From,obtained
R4060 T16000 T16001 det the,injections
R4061 T16001 T15998 pobj injections,From
R4062 T16002 T16001 prep at,injections
R4063 T16003 T16004 det the,University
R4064 T16004 T16002 pobj University,at
R4065 T16005 T16004 prep of,University
R4066 T16006 T16005 pobj Cincinnati,of
R4067 T16007 T15999 punct ", ",obtained
R4068 T16008 T15999 nsubj we,obtained
R4069 T16009 T16010 nummod 8,founders
R4070 T16010 T15999 dobj founders,obtained
R4071 T16011 T16012 npadvmod transgene,positive
R4072 T16012 T16010 amod positive,founders
R4073 T16013 T15999 punct .,obtained
R4074 T16015 T16016 amod Subsequent,breeding
R4075 T16016 T16017 nsubj breeding,revealed
R4076 T16018 T16016 prep of,breeding
R4077 T16019 T16020 det these,founders
R4078 T16020 T16018 pobj founders,of
R4079 T16021 T16022 mark that,had
R4080 T16022 T16017 ccomp had,revealed
R4081 T16023 T16022 nsubj many,had
R4082 T16024 T16023 prep of,many
R4083 T16025 T16026 det the,animals
R4084 T16026 T16024 pobj animals,of
R4085 T16027 T16028 amod multiple,sites
R4086 T16028 T16022 dobj sites,had
R4087 T16029 T16028 compound transgene,sites
R4088 T16030 T16028 compound insertion,sites
R4089 T16031 T16032 dep that,segregated
R4090 T16032 T16028 relcl segregated,sites
R4091 T16033 T16017 punct .,revealed
R4092 T16035 T16036 nsubj We,established
R4093 T16037 T16038 det a,total
R4094 T16038 T16036 dobj total,established
R4095 T16039 T16038 prep of,total
R4096 T16040 T16041 nummod 15,lines
R4097 T16041 T16039 pobj lines,of
R4098 T16042 T16041 amod different,lines
R4099 T16043 T16041 amod transgenic,lines
R4100 T16044 T16036 prep from,established
R4101 T16045 T16046 det these,founders
R4102 T16046 T16044 pobj founders,from
R4103 T16047 T16036 punct .,established
R4104 T16049 T16050 amod Limited,resources
R4105 T16050 T16051 nsubj resources,allowed
R4106 T16052 T16053 nsubj us,focus
R4107 T16053 T16051 ccomp focus,allowed
R4108 T16054 T16053 aux to,focus
R4109 T16055 T16053 advmod only,focus
R4110 T16056 T16053 prep on,focus
R4111 T16057 T16058 det a,total
R4112 T16058 T16056 pobj total,on
R4113 T16059 T16058 prep of,total
R4114 T16060 T16059 pobj 9,of
R4115 T16061 T16060 prep of,9
R4116 T16062 T16063 det these,lines
R4117 T16063 T16061 pobj lines,of
R4118 T16064 T16051 punct .,allowed
R4119 T16066 T16067 det These,lines
R4120 T16067 T16068 nsubj lines,differed
R4121 T16069 T16068 advmod substantially,differed
R4122 T16070 T16068 prep in,differed
R4123 T16071 T16072 compound transgene,number
R4124 T16072 T16070 pobj number,in
R4125 T16073 T16072 compound copy,number
R4126 T16074 T16075 mark as,compared
R4127 T16075 T16068 advcl compared,differed
R4128 T16076 T16075 prep by,compared
R4129 T16077 T16078 compound Southern,blot
R4130 T16078 T16079 compound blot,analysis
R4131 T16079 T16076 pobj analysis,by
R4132 T16080 T16079 prep of,analysis
R4133 T16081 T16082 compound tail,DNA
R4134 T16082 T16080 pobj DNA,of
R4135 T16083 T16084 punct (,shown
R4136 T16084 T16068 parataxis shown,differed
R4137 T16085 T16084 nsubj data,shown
R4138 T16086 T16084 neg not,shown
R4139 T16087 T16084 punct ),shown
R4140 T16088 T16068 punct .,differed
R3993 T15897 T15898 nmod LAP,tTA
R3994 T15898 T15900 nmod tTA,mice
R3995 T15899 T15898 punct -,tTA
R3996 T15903 T15902 auxpass w,e
R3997 T15904 T15902 advcl re,e
R3998 T15919 T15920 amod c,e
R3999 T15923 T15922 cc and,d
R4000 T15924 T15922 conj c,d
R4001 T15930 T15929 acl a,r
R4002 T15932 T15928 aux t,r
R4003 T15933 T15928 auxpass e,r
R4004 T15937 T15936 agent by,zed
R4005 T15938 T15939 det the,laboratory
R4006 T15939 T15937 pobj laboratory,by
R4007 T15940 T15939 compound Bujard,laboratory

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T15567 840-843 CHEBI_SO_EXT:DNA denotes DNA
T15566 835-839 UBERON:0002415 denotes tail
T15540 8-12 NCBITaxon:10088 denotes mice
T15539 0-3 PR_EXT:000005308 denotes LAP
T15565 782-786 SO_EXT:sequence_copy_entity denotes copy
T15564 772-781 SO_EXT:0000902 denotes transgene
T15563 621-631 SO_EXT:transgenic_entity denotes transgenic
T15562 549-564 SO_EXT:0000366 denotes insertion sites
T15561 539-548 SO_EXT:0000902 denotes transgene
T15560 518-525 NCBITaxon:33208 denotes animals
T15559 465-473 GO_EXT:breeding denotes breeding
T15558 425-434 SO_EXT:0000902 denotes transgene
T15557 322-332 SO_EXT:transgenic_entity denotes transgenic
T15556 236-245 SO_EXT:0000902 denotes transgene
T15555 174-183 SO_EXT:0000902 denotes transgene
T15554 171-173 PR_EXT:000006300 denotes E2
T15553 144-148 NCBITaxon:10088 denotes mice
T15552 133-143 SO_EXT:transgenic_entity denotes transgenic
T15551 87-97 GO:0045120 denotes Pronuclear
T15550 51-52 NCBITaxon:10088 denotes i
T15549 45-46 CHEBI_PR_EXT:protein denotes r
T15548 42-43 UBERON_EXT:muscle_structure_or_tissue denotes c
T15547 36-37 UBERON:0002113 denotes d
T15546 35-36 NCBITaxon:10088 denotes e
T15545 34-35 SO_EXT:transgenic_entity denotes c
T15544 33-34 NCBITaxon:9606 denotes u
T15543 32-33 GO:0042571 denotes d
T15542 21-22 UBERON:0002107 denotes v
T15541 18-21 CHEBI_PR_EXT:protein denotes pre

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T15399 835-839 UBERON:0002415 denotes tail
T15398 772-781 SO:0000902 denotes transgene
T15397 549-564 SO:0000366 denotes insertion sites
T15396 539-548 SO:0000902 denotes transgene
T15395 518-525 NCBITaxon:33208 denotes animals
T15394 425-434 SO:0000902 denotes transgene
T15393 236-245 SO:0000902 denotes transgene
T15392 174-183 SO:0000902 denotes transgene
T15391 171-173 PR:000006300 denotes E2
T15390 144-148 NCBITaxon:10088 denotes mice
T15389 87-97 GO:0045120 denotes Pronuclear
T15388 51-52 NCBITaxon:10088 denotes i
T15387 36-37 UBERON:0002113 denotes d
T15386 35-36 NCBITaxon:10088 denotes e
T15385 33-34 NCBITaxon:9606 denotes u
T15384 32-33 GO:0042571 denotes d
T15383 21-22 UBERON:0002107 denotes v
T15382 8-12 NCBITaxon:10088 denotes mice
T15381 0-3 PR:000005308 denotes LAP