Id |
Subject |
Object |
Predicate |
Lexical cue |
T6426 |
0-10 |
NN |
denotes |
Production |
T6427 |
11-13 |
IN |
denotes |
of |
T6428 |
14-26 |
JJ |
denotes |
intermediate |
T6429 |
39-44 |
NN |
denotes |
model |
T6430 |
27-31 |
NN |
denotes |
MSUD |
T6431 |
32-38 |
JJ |
denotes |
murine |
T6432 |
44-301 |
sentence |
denotes |
The various TRE-E2 transgenic lines produced were mated independently to mice that were heterozygous for both the E2 knockout and the LAP-tTA transgene [Tg(tTALap)Bjd/J; Stock 3272; The Jackson Laboratory, Bar Harbor, ME; NMRI × FVB × C57BL/6J background]. |
T6433 |
45-48 |
DT |
denotes |
The |
T6434 |
75-80 |
NNS |
denotes |
lines |
T6435 |
49-56 |
JJ |
denotes |
various |
T6436 |
57-60 |
NN |
denotes |
TRE |
T6437 |
61-63 |
NN |
denotes |
E2 |
T6438 |
60-61 |
HYPH |
denotes |
- |
T6439 |
64-74 |
JJ |
denotes |
transgenic |
T6440 |
95-100 |
VBN |
denotes |
mated |
T6441 |
81-89 |
VBN |
denotes |
produced |
T6442 |
90-94 |
VBD |
denotes |
were |
T6443 |
101-114 |
RB |
denotes |
independently |
T6444 |
115-117 |
IN |
denotes |
to |
T6445 |
118-122 |
NNS |
denotes |
mice |
T6446 |
123-127 |
WDT |
denotes |
that |
T6447 |
128-132 |
VBD |
denotes |
were |
T6448 |
133-145 |
JJ |
denotes |
heterozygous |
T6449 |
146-149 |
IN |
denotes |
for |
T6450 |
150-154 |
CC |
denotes |
both |
T6451 |
162-170 |
NN |
denotes |
knockout |
T6452 |
155-158 |
DT |
denotes |
the |
T6453 |
159-161 |
NN |
denotes |
E2 |
T6454 |
171-174 |
CC |
denotes |
and |
T6455 |
175-178 |
DT |
denotes |
the |
T6456 |
187-196 |
NN |
denotes |
transgene |
T6457 |
179-182 |
NN |
denotes |
LAP |
T6458 |
183-186 |
NN |
denotes |
tTA |
T6459 |
182-183 |
HYPH |
denotes |
- |
T6460 |
197-198 |
-LRB- |
denotes |
[ |
T6461 |
289-299 |
NN |
denotes |
background |
T6462 |
198-200 |
NN |
denotes |
Tg |
T6463 |
215-220 |
NN |
denotes |
Stock |
T6464 |
200-201 |
-LRB- |
denotes |
( |
T6465 |
201-207 |
NN |
denotes |
tTALap |
T6466 |
207-208 |
-RRB- |
denotes |
) |
T6467 |
208-211 |
NN |
denotes |
Bjd |
T6468 |
212-213 |
NN |
denotes |
J |
T6469 |
211-212 |
HYPH |
denotes |
/ |
T6470 |
213-214 |
: |
denotes |
; |
T6471 |
221-225 |
CD |
denotes |
3272 |
T6472 |
225-226 |
: |
denotes |
; |
T6473 |
227-230 |
DT |
denotes |
The |
T6474 |
239-249 |
NNP |
denotes |
Laboratory |
T6475 |
231-238 |
NNP |
denotes |
Jackson |
T6476 |
249-251 |
, |
denotes |
, |
T6477 |
251-254 |
NNP |
denotes |
Bar |
T6478 |
255-261 |
NNP |
denotes |
Harbor |
T6479 |
261-263 |
, |
denotes |
, |
T6480 |
263-265 |
NNP |
denotes |
ME |
T6481 |
265-266 |
: |
denotes |
; |
T6482 |
267-271 |
NN |
denotes |
NMRI |
T6483 |
272-273 |
SYM |
denotes |
× |
T6484 |
274-277 |
NN |
denotes |
FVB |
T6485 |
278-279 |
SYM |
denotes |
× |
T6486 |
280-285 |
NN |
denotes |
C57BL |
T6487 |
286-288 |
NN |
denotes |
6J |
T6488 |
285-286 |
HYPH |
denotes |
/ |
T6489 |
299-300 |
-RRB- |
denotes |
] |
T6490 |
300-301 |
. |
denotes |
. |
T6491 |
301-602 |
sentence |
denotes |
Interbreeding of animals that were heterozygous for both transgenes and the knockout resulted in the production of mice with a variety of genotypes including some animals that were homozygous for the knockout and were positive for both transgenes (we refer to this genotype as the "rescue" genotype). |
T6492 |
302-315 |
NN |
denotes |
Interbreeding |
T6493 |
387-395 |
VBD |
denotes |
resulted |
T6494 |
316-318 |
IN |
denotes |
of |
T6495 |
319-326 |
NNS |
denotes |
animals |
T6496 |
327-331 |
WDT |
denotes |
that |
T6497 |
332-336 |
VBD |
denotes |
were |
T6498 |
337-349 |
JJ |
denotes |
heterozygous |
T6499 |
350-353 |
IN |
denotes |
for |
T6500 |
354-358 |
DT |
denotes |
both |
T6501 |
359-369 |
NNS |
denotes |
transgenes |
T6502 |
370-373 |
CC |
denotes |
and |
T6503 |
374-377 |
DT |
denotes |
the |
T6504 |
378-386 |
NN |
denotes |
knockout |
T6505 |
396-398 |
IN |
denotes |
in |
T6506 |
399-402 |
DT |
denotes |
the |
T6507 |
403-413 |
NN |
denotes |
production |
T6508 |
414-416 |
IN |
denotes |
of |
T6509 |
417-421 |
NNS |
denotes |
mice |
T6510 |
422-426 |
IN |
denotes |
with |
T6511 |
427-428 |
DT |
denotes |
a |
T6512 |
429-436 |
NN |
denotes |
variety |
T6513 |
437-439 |
IN |
denotes |
of |
T6514 |
440-449 |
NNS |
denotes |
genotypes |
T6515 |
450-459 |
VBG |
denotes |
including |
T6516 |
460-464 |
DT |
denotes |
some |
T6517 |
465-472 |
NNS |
denotes |
animals |
T6518 |
473-477 |
WDT |
denotes |
that |
T6519 |
478-482 |
VBD |
denotes |
were |
T6520 |
483-493 |
JJ |
denotes |
homozygous |
T6521 |
494-497 |
IN |
denotes |
for |
T6522 |
498-501 |
DT |
denotes |
the |
T6523 |
502-510 |
NN |
denotes |
knockout |
T6524 |
511-514 |
CC |
denotes |
and |
T6525 |
515-519 |
VBD |
denotes |
were |
T6526 |
520-528 |
JJ |
denotes |
positive |
T6527 |
529-532 |
IN |
denotes |
for |
T6528 |
533-537 |
DT |
denotes |
both |
T6529 |
538-548 |
NNS |
denotes |
transgenes |
T6530 |
549-550 |
-LRB- |
denotes |
( |
T6531 |
553-558 |
VBP |
denotes |
refer |
T6532 |
550-552 |
PRP |
denotes |
we |
T6533 |
559-561 |
IN |
denotes |
to |
T6534 |
562-566 |
DT |
denotes |
this |
T6535 |
567-575 |
NN |
denotes |
genotype |
T6536 |
576-578 |
IN |
denotes |
as |
T6537 |
579-582 |
DT |
denotes |
the |
T6538 |
592-600 |
NN |
denotes |
genotype |
T6539 |
583-584 |
`` |
denotes |
" |
T6540 |
584-590 |
NN |
denotes |
rescue |
T6541 |
590-591 |
'' |
denotes |
" |
T6542 |
600-601 |
-RRB- |
denotes |
) |
T6543 |
601-602 |
. |
denotes |
. |
T6544 |
602-800 |
sentence |
denotes |
If our strategy for rescuing the neonatal lethal phenotype of the knockout were successful, then those homozygous knockout animals that had both transgenes would survive beyond the neonatal period. |
T6545 |
603-605 |
IN |
denotes |
If |
T6546 |
678-682 |
VBD |
denotes |
were |
T6547 |
606-609 |
PRP$ |
denotes |
our |
T6548 |
610-618 |
NN |
denotes |
strategy |
T6549 |
619-622 |
IN |
denotes |
for |
T6550 |
623-631 |
VBG |
denotes |
rescuing |
T6551 |
632-635 |
DT |
denotes |
the |
T6552 |
652-661 |
NN |
denotes |
phenotype |
T6553 |
636-644 |
JJ |
denotes |
neonatal |
T6554 |
645-651 |
JJ |
denotes |
lethal |
T6555 |
662-664 |
IN |
denotes |
of |
T6556 |
665-668 |
DT |
denotes |
the |
T6557 |
669-677 |
NN |
denotes |
knockout |
T6558 |
765-772 |
VB |
denotes |
survive |
T6559 |
683-693 |
JJ |
denotes |
successful |
T6560 |
693-695 |
, |
denotes |
, |
T6561 |
695-699 |
RB |
denotes |
then |
T6562 |
700-705 |
DT |
denotes |
those |
T6563 |
726-733 |
NNS |
denotes |
animals |
T6564 |
706-716 |
JJ |
denotes |
homozygous |
T6565 |
717-725 |
NN |
denotes |
knockout |
T6566 |
734-738 |
WDT |
denotes |
that |
T6567 |
739-742 |
VBD |
denotes |
had |
T6568 |
743-747 |
DT |
denotes |
both |
T6569 |
748-758 |
NNS |
denotes |
transgenes |
T6570 |
759-764 |
MD |
denotes |
would |
T6571 |
773-779 |
IN |
denotes |
beyond |
T6572 |
780-783 |
DT |
denotes |
the |
T6573 |
793-799 |
NN |
denotes |
period |
T6574 |
784-792 |
JJ |
denotes |
neonatal |
T6575 |
799-800 |
. |
denotes |
. |
R1828 |
T6427 |
T6426 |
prep |
of,Production |
R1829 |
T6428 |
T6429 |
amod |
intermediate,model |
R1830 |
T6429 |
T6427 |
pobj |
model,of |
R1831 |
T6430 |
T6429 |
nmod |
MSUD,model |
R1832 |
T6431 |
T6429 |
amod |
murine,model |
R1833 |
T6433 |
T6434 |
det |
The,lines |
R1834 |
T6434 |
T6440 |
nsubjpass |
lines,mated |
R1835 |
T6435 |
T6434 |
amod |
various,lines |
R1836 |
T6436 |
T6437 |
nmod |
TRE,E2 |
R1837 |
T6437 |
T6434 |
nmod |
E2,lines |
R1838 |
T6438 |
T6437 |
punct |
-,E2 |
R1839 |
T6439 |
T6434 |
amod |
transgenic,lines |
R1840 |
T6441 |
T6434 |
acl |
produced,lines |
R1841 |
T6442 |
T6440 |
auxpass |
were,mated |
R1842 |
T6443 |
T6440 |
advmod |
independently,mated |
R1843 |
T6444 |
T6440 |
prep |
to,mated |
R1844 |
T6445 |
T6444 |
pobj |
mice,to |
R1845 |
T6446 |
T6447 |
dep |
that,were |
R1846 |
T6447 |
T6445 |
relcl |
were,mice |
R1847 |
T6448 |
T6447 |
acomp |
heterozygous,were |
R1848 |
T6449 |
T6448 |
prep |
for,heterozygous |
R1849 |
T6450 |
T6451 |
preconj |
both,knockout |
R1850 |
T6451 |
T6449 |
pobj |
knockout,for |
R1851 |
T6452 |
T6451 |
det |
the,knockout |
R1852 |
T6453 |
T6451 |
compound |
E2,knockout |
R1853 |
T6454 |
T6451 |
cc |
and,knockout |
R1854 |
T6455 |
T6456 |
det |
the,transgene |
R1855 |
T6456 |
T6451 |
conj |
transgene,knockout |
R1856 |
T6457 |
T6458 |
compound |
LAP,tTA |
R1857 |
T6458 |
T6456 |
compound |
tTA,transgene |
R1858 |
T6459 |
T6458 |
punct |
-,tTA |
R1859 |
T6460 |
T6461 |
punct |
[,background |
R1860 |
T6461 |
T6440 |
parataxis |
background,mated |
R1861 |
T6462 |
T6463 |
nmod |
Tg,Stock |
R1862 |
T6463 |
T6461 |
dep |
Stock,background |
R1863 |
T6464 |
T6465 |
punct |
(,tTALap |
R1864 |
T6465 |
T6463 |
parataxis |
tTALap,Stock |
R1865 |
T6466 |
T6465 |
punct |
),tTALap |
R1866 |
T6467 |
T6468 |
nmod |
Bjd,J |
R1867 |
T6468 |
T6463 |
nmod |
J,Stock |
R1868 |
T6469 |
T6468 |
punct |
/,J |
R1869 |
T6470 |
T6463 |
punct |
;,Stock |
R1870 |
T6471 |
T6463 |
nummod |
3272,Stock |
R1871 |
T6472 |
T6461 |
punct |
;,background |
R1872 |
T6473 |
T6474 |
det |
The,Laboratory |
R1873 |
T6474 |
T6461 |
dep |
Laboratory,background |
R1874 |
T6475 |
T6474 |
compound |
Jackson,Laboratory |
R1875 |
T6476 |
T6474 |
punct |
", ",Laboratory |
R1876 |
T6477 |
T6478 |
compound |
Bar,Harbor |
R1877 |
T6478 |
T6474 |
npadvmod |
Harbor,Laboratory |
R1878 |
T6479 |
T6474 |
punct |
", ",Laboratory |
R1879 |
T6480 |
T6474 |
npadvmod |
ME,Laboratory |
R1880 |
T6481 |
T6461 |
punct |
;,background |
R1881 |
T6482 |
T6461 |
nmod |
NMRI,background |
R1882 |
T6483 |
T6482 |
punct |
×,NMRI |
R1883 |
T6484 |
T6482 |
appos |
FVB,NMRI |
R1884 |
T6485 |
T6482 |
punct |
×,NMRI |
R1885 |
T6486 |
T6487 |
compound |
C57BL,6J |
R1886 |
T6487 |
T6482 |
appos |
6J,NMRI |
R1887 |
T6488 |
T6487 |
punct |
/,6J |
R1888 |
T6489 |
T6461 |
punct |
],background |
R1889 |
T6490 |
T6440 |
punct |
.,mated |
R1890 |
T6492 |
T6493 |
nsubj |
Interbreeding,resulted |
R1891 |
T6494 |
T6492 |
prep |
of,Interbreeding |
R1892 |
T6495 |
T6494 |
pobj |
animals,of |
R1893 |
T6496 |
T6497 |
dep |
that,were |
R1894 |
T6497 |
T6495 |
relcl |
were,animals |
R1895 |
T6498 |
T6497 |
acomp |
heterozygous,were |
R1896 |
T6499 |
T6498 |
prep |
for,heterozygous |
R1897 |
T6500 |
T6501 |
det |
both,transgenes |
R1898 |
T6501 |
T6499 |
pobj |
transgenes,for |
R1899 |
T6502 |
T6501 |
cc |
and,transgenes |
R1900 |
T6503 |
T6504 |
det |
the,knockout |
R1901 |
T6504 |
T6501 |
conj |
knockout,transgenes |
R1902 |
T6505 |
T6493 |
prep |
in,resulted |
R1903 |
T6506 |
T6507 |
det |
the,production |
R1904 |
T6507 |
T6505 |
pobj |
production,in |
R1905 |
T6508 |
T6507 |
prep |
of,production |
R1906 |
T6509 |
T6508 |
pobj |
mice,of |
R1907 |
T6510 |
T6509 |
prep |
with,mice |
R1908 |
T6511 |
T6512 |
det |
a,variety |
R1909 |
T6512 |
T6510 |
pobj |
variety,with |
R1910 |
T6513 |
T6512 |
prep |
of,variety |
R1911 |
T6514 |
T6513 |
pobj |
genotypes,of |
R1912 |
T6515 |
T6509 |
prep |
including,mice |
R1913 |
T6516 |
T6517 |
det |
some,animals |
R1914 |
T6517 |
T6515 |
pobj |
animals,including |
R1915 |
T6518 |
T6519 |
dep |
that,were |
R1916 |
T6519 |
T6517 |
relcl |
were,animals |
R1917 |
T6520 |
T6519 |
acomp |
homozygous,were |
R1918 |
T6521 |
T6520 |
prep |
for,homozygous |
R1919 |
T6522 |
T6523 |
det |
the,knockout |
R1920 |
T6523 |
T6521 |
pobj |
knockout,for |
R1921 |
T6524 |
T6519 |
cc |
and,were |
R1922 |
T6525 |
T6519 |
conj |
were,were |
R1923 |
T6526 |
T6525 |
acomp |
positive,were |
R1924 |
T6527 |
T6526 |
prep |
for,positive |
R1925 |
T6528 |
T6529 |
det |
both,transgenes |
R1926 |
T6529 |
T6527 |
pobj |
transgenes,for |
R1927 |
T6530 |
T6531 |
punct |
(,refer |
R1928 |
T6531 |
T6525 |
parataxis |
refer,were |
R1929 |
T6532 |
T6531 |
nsubj |
we,refer |
R1930 |
T6533 |
T6531 |
prep |
to,refer |
R1931 |
T6534 |
T6535 |
det |
this,genotype |
R1932 |
T6535 |
T6533 |
pobj |
genotype,to |
R1933 |
T6536 |
T6531 |
prep |
as,refer |
R1934 |
T6537 |
T6538 |
det |
the,genotype |
R1935 |
T6538 |
T6536 |
pobj |
genotype,as |
R1936 |
T6539 |
T6538 |
punct |
"""",genotype |
R1937 |
T6540 |
T6538 |
nmod |
rescue,genotype |
R1938 |
T6541 |
T6538 |
punct |
"""",genotype |
R1939 |
T6542 |
T6531 |
punct |
),refer |
R1940 |
T6543 |
T6493 |
punct |
.,resulted |
R1941 |
T6545 |
T6546 |
mark |
If,were |
R1942 |
T6546 |
T6558 |
advcl |
were,survive |
R1943 |
T6547 |
T6548 |
poss |
our,strategy |
R1944 |
T6548 |
T6546 |
nsubj |
strategy,were |
R1945 |
T6549 |
T6548 |
prep |
for,strategy |
R1946 |
T6550 |
T6549 |
pcomp |
rescuing,for |
R1947 |
T6551 |
T6552 |
det |
the,phenotype |
R1948 |
T6552 |
T6550 |
dobj |
phenotype,rescuing |
R1949 |
T6553 |
T6552 |
amod |
neonatal,phenotype |
R1950 |
T6554 |
T6552 |
amod |
lethal,phenotype |
R1951 |
T6555 |
T6552 |
prep |
of,phenotype |
R1952 |
T6556 |
T6557 |
det |
the,knockout |
R1953 |
T6557 |
T6555 |
pobj |
knockout,of |
R1954 |
T6559 |
T6546 |
acomp |
successful,were |
R1955 |
T6560 |
T6558 |
punct |
", ",survive |
R1956 |
T6561 |
T6558 |
advmod |
then,survive |
R1957 |
T6562 |
T6563 |
det |
those,animals |
R1958 |
T6563 |
T6558 |
nsubj |
animals,survive |
R1959 |
T6564 |
T6563 |
amod |
homozygous,animals |
R1960 |
T6565 |
T6563 |
compound |
knockout,animals |
R1961 |
T6566 |
T6567 |
dep |
that,had |
R1962 |
T6567 |
T6563 |
relcl |
had,animals |
R1963 |
T6568 |
T6569 |
det |
both,transgenes |
R1964 |
T6569 |
T6567 |
dobj |
transgenes,had |
R1965 |
T6570 |
T6558 |
aux |
would,survive |
R1966 |
T6571 |
T6558 |
prep |
beyond,survive |
R1967 |
T6572 |
T6573 |
det |
the,period |
R1968 |
T6573 |
T6571 |
pobj |
period,beyond |
R1969 |
T6574 |
T6573 |
amod |
neonatal,period |
R1970 |
T6575 |
T6558 |
punct |
.,survive |