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PMC:1448208 / 11495-12295 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T6426 0-10 NN denotes Production
T6427 11-13 IN denotes of
T6428 14-26 JJ denotes intermediate
T6429 39-44 NN denotes model
T6430 27-31 NN denotes MSUD
T6431 32-38 JJ denotes murine
T6432 44-301 sentence denotes The various TRE-E2 transgenic lines produced were mated independently to mice that were heterozygous for both the E2 knockout and the LAP-tTA transgene [Tg(tTALap)Bjd/J; Stock 3272; The Jackson Laboratory, Bar Harbor, ME; NMRI × FVB × C57BL/6J background].
T6433 45-48 DT denotes The
T6434 75-80 NNS denotes lines
T6435 49-56 JJ denotes various
T6436 57-60 NN denotes TRE
T6437 61-63 NN denotes E2
T6438 60-61 HYPH denotes -
T6439 64-74 JJ denotes transgenic
T6440 95-100 VBN denotes mated
T6441 81-89 VBN denotes produced
T6442 90-94 VBD denotes were
T6443 101-114 RB denotes independently
T6444 115-117 IN denotes to
T6445 118-122 NNS denotes mice
T6446 123-127 WDT denotes that
T6447 128-132 VBD denotes were
T6448 133-145 JJ denotes heterozygous
T6449 146-149 IN denotes for
T6450 150-154 CC denotes both
T6451 162-170 NN denotes knockout
T6452 155-158 DT denotes the
T6453 159-161 NN denotes E2
T6454 171-174 CC denotes and
T6455 175-178 DT denotes the
T6456 187-196 NN denotes transgene
T6457 179-182 NN denotes LAP
T6458 183-186 NN denotes tTA
T6459 182-183 HYPH denotes -
T6460 197-198 -LRB- denotes [
T6461 289-299 NN denotes background
T6462 198-200 NN denotes Tg
T6463 215-220 NN denotes Stock
T6464 200-201 -LRB- denotes (
T6465 201-207 NN denotes tTALap
T6466 207-208 -RRB- denotes )
T6467 208-211 NN denotes Bjd
T6468 212-213 NN denotes J
T6469 211-212 HYPH denotes /
T6470 213-214 : denotes ;
T6471 221-225 CD denotes 3272
T6472 225-226 : denotes ;
T6473 227-230 DT denotes The
T6474 239-249 NNP denotes Laboratory
T6475 231-238 NNP denotes Jackson
T6476 249-251 , denotes ,
T6477 251-254 NNP denotes Bar
T6478 255-261 NNP denotes Harbor
T6479 261-263 , denotes ,
T6480 263-265 NNP denotes ME
T6481 265-266 : denotes ;
T6482 267-271 NN denotes NMRI
T6483 272-273 SYM denotes ×
T6484 274-277 NN denotes FVB
T6485 278-279 SYM denotes ×
T6486 280-285 NN denotes C57BL
T6487 286-288 NN denotes 6J
T6488 285-286 HYPH denotes /
T6489 299-300 -RRB- denotes ]
T6490 300-301 . denotes .
T6491 301-602 sentence denotes Interbreeding of animals that were heterozygous for both transgenes and the knockout resulted in the production of mice with a variety of genotypes including some animals that were homozygous for the knockout and were positive for both transgenes (we refer to this genotype as the "rescue" genotype).
T6492 302-315 NN denotes Interbreeding
T6493 387-395 VBD denotes resulted
T6494 316-318 IN denotes of
T6495 319-326 NNS denotes animals
T6496 327-331 WDT denotes that
T6497 332-336 VBD denotes were
T6498 337-349 JJ denotes heterozygous
T6499 350-353 IN denotes for
T6500 354-358 DT denotes both
T6501 359-369 NNS denotes transgenes
T6502 370-373 CC denotes and
T6503 374-377 DT denotes the
T6504 378-386 NN denotes knockout
T6505 396-398 IN denotes in
T6506 399-402 DT denotes the
T6507 403-413 NN denotes production
T6508 414-416 IN denotes of
T6509 417-421 NNS denotes mice
T6510 422-426 IN denotes with
T6511 427-428 DT denotes a
T6512 429-436 NN denotes variety
T6513 437-439 IN denotes of
T6514 440-449 NNS denotes genotypes
T6515 450-459 VBG denotes including
T6516 460-464 DT denotes some
T6517 465-472 NNS denotes animals
T6518 473-477 WDT denotes that
T6519 478-482 VBD denotes were
T6520 483-493 JJ denotes homozygous
T6521 494-497 IN denotes for
T6522 498-501 DT denotes the
T6523 502-510 NN denotes knockout
T6524 511-514 CC denotes and
T6525 515-519 VBD denotes were
T6526 520-528 JJ denotes positive
T6527 529-532 IN denotes for
T6528 533-537 DT denotes both
T6529 538-548 NNS denotes transgenes
T6530 549-550 -LRB- denotes (
T6531 553-558 VBP denotes refer
T6532 550-552 PRP denotes we
T6533 559-561 IN denotes to
T6534 562-566 DT denotes this
T6535 567-575 NN denotes genotype
T6536 576-578 IN denotes as
T6537 579-582 DT denotes the
T6538 592-600 NN denotes genotype
T6539 583-584 `` denotes "
T6540 584-590 NN denotes rescue
T6541 590-591 '' denotes "
T6542 600-601 -RRB- denotes )
T6543 601-602 . denotes .
T6544 602-800 sentence denotes If our strategy for rescuing the neonatal lethal phenotype of the knockout were successful, then those homozygous knockout animals that had both transgenes would survive beyond the neonatal period.
T6545 603-605 IN denotes If
T6546 678-682 VBD denotes were
T6547 606-609 PRP$ denotes our
T6548 610-618 NN denotes strategy
T6549 619-622 IN denotes for
T6550 623-631 VBG denotes rescuing
T6551 632-635 DT denotes the
T6552 652-661 NN denotes phenotype
T6553 636-644 JJ denotes neonatal
T6554 645-651 JJ denotes lethal
T6555 662-664 IN denotes of
T6556 665-668 DT denotes the
T6557 669-677 NN denotes knockout
T6558 765-772 VB denotes survive
T6559 683-693 JJ denotes successful
T6560 693-695 , denotes ,
T6561 695-699 RB denotes then
T6562 700-705 DT denotes those
T6563 726-733 NNS denotes animals
T6564 706-716 JJ denotes homozygous
T6565 717-725 NN denotes knockout
T6566 734-738 WDT denotes that
T6567 739-742 VBD denotes had
T6568 743-747 DT denotes both
T6569 748-758 NNS denotes transgenes
T6570 759-764 MD denotes would
T6571 773-779 IN denotes beyond
T6572 780-783 DT denotes the
T6573 793-799 NN denotes period
T6574 784-792 JJ denotes neonatal
T6575 799-800 . denotes .
R1828 T6427 T6426 prep of,Production
R1829 T6428 T6429 amod intermediate,model
R1830 T6429 T6427 pobj model,of
R1831 T6430 T6429 nmod MSUD,model
R1832 T6431 T6429 amod murine,model
R1833 T6433 T6434 det The,lines
R1834 T6434 T6440 nsubjpass lines,mated
R1835 T6435 T6434 amod various,lines
R1836 T6436 T6437 nmod TRE,E2
R1837 T6437 T6434 nmod E2,lines
R1838 T6438 T6437 punct -,E2
R1839 T6439 T6434 amod transgenic,lines
R1840 T6441 T6434 acl produced,lines
R1841 T6442 T6440 auxpass were,mated
R1842 T6443 T6440 advmod independently,mated
R1843 T6444 T6440 prep to,mated
R1844 T6445 T6444 pobj mice,to
R1845 T6446 T6447 dep that,were
R1846 T6447 T6445 relcl were,mice
R1847 T6448 T6447 acomp heterozygous,were
R1848 T6449 T6448 prep for,heterozygous
R1849 T6450 T6451 preconj both,knockout
R1850 T6451 T6449 pobj knockout,for
R1851 T6452 T6451 det the,knockout
R1852 T6453 T6451 compound E2,knockout
R1853 T6454 T6451 cc and,knockout
R1854 T6455 T6456 det the,transgene
R1855 T6456 T6451 conj transgene,knockout
R1856 T6457 T6458 compound LAP,tTA
R1857 T6458 T6456 compound tTA,transgene
R1858 T6459 T6458 punct -,tTA
R1859 T6460 T6461 punct [,background
R1860 T6461 T6440 parataxis background,mated
R1861 T6462 T6463 nmod Tg,Stock
R1862 T6463 T6461 dep Stock,background
R1863 T6464 T6465 punct (,tTALap
R1864 T6465 T6463 parataxis tTALap,Stock
R1865 T6466 T6465 punct ),tTALap
R1866 T6467 T6468 nmod Bjd,J
R1867 T6468 T6463 nmod J,Stock
R1868 T6469 T6468 punct /,J
R1869 T6470 T6463 punct ;,Stock
R1870 T6471 T6463 nummod 3272,Stock
R1871 T6472 T6461 punct ;,background
R1872 T6473 T6474 det The,Laboratory
R1873 T6474 T6461 dep Laboratory,background
R1874 T6475 T6474 compound Jackson,Laboratory
R1875 T6476 T6474 punct ", ",Laboratory
R1876 T6477 T6478 compound Bar,Harbor
R1877 T6478 T6474 npadvmod Harbor,Laboratory
R1878 T6479 T6474 punct ", ",Laboratory
R1879 T6480 T6474 npadvmod ME,Laboratory
R1880 T6481 T6461 punct ;,background
R1881 T6482 T6461 nmod NMRI,background
R1882 T6483 T6482 punct ×,NMRI
R1883 T6484 T6482 appos FVB,NMRI
R1884 T6485 T6482 punct ×,NMRI
R1885 T6486 T6487 compound C57BL,6J
R1886 T6487 T6482 appos 6J,NMRI
R1887 T6488 T6487 punct /,6J
R1888 T6489 T6461 punct ],background
R1889 T6490 T6440 punct .,mated
R1890 T6492 T6493 nsubj Interbreeding,resulted
R1891 T6494 T6492 prep of,Interbreeding
R1892 T6495 T6494 pobj animals,of
R1893 T6496 T6497 dep that,were
R1894 T6497 T6495 relcl were,animals
R1895 T6498 T6497 acomp heterozygous,were
R1896 T6499 T6498 prep for,heterozygous
R1897 T6500 T6501 det both,transgenes
R1898 T6501 T6499 pobj transgenes,for
R1899 T6502 T6501 cc and,transgenes
R1900 T6503 T6504 det the,knockout
R1901 T6504 T6501 conj knockout,transgenes
R1902 T6505 T6493 prep in,resulted
R1903 T6506 T6507 det the,production
R1904 T6507 T6505 pobj production,in
R1905 T6508 T6507 prep of,production
R1906 T6509 T6508 pobj mice,of
R1907 T6510 T6509 prep with,mice
R1908 T6511 T6512 det a,variety
R1909 T6512 T6510 pobj variety,with
R1910 T6513 T6512 prep of,variety
R1911 T6514 T6513 pobj genotypes,of
R1912 T6515 T6509 prep including,mice
R1913 T6516 T6517 det some,animals
R1914 T6517 T6515 pobj animals,including
R1915 T6518 T6519 dep that,were
R1916 T6519 T6517 relcl were,animals
R1917 T6520 T6519 acomp homozygous,were
R1918 T6521 T6520 prep for,homozygous
R1919 T6522 T6523 det the,knockout
R1920 T6523 T6521 pobj knockout,for
R1921 T6524 T6519 cc and,were
R1922 T6525 T6519 conj were,were
R1923 T6526 T6525 acomp positive,were
R1924 T6527 T6526 prep for,positive
R1925 T6528 T6529 det both,transgenes
R1926 T6529 T6527 pobj transgenes,for
R1927 T6530 T6531 punct (,refer
R1928 T6531 T6525 parataxis refer,were
R1929 T6532 T6531 nsubj we,refer
R1930 T6533 T6531 prep to,refer
R1931 T6534 T6535 det this,genotype
R1932 T6535 T6533 pobj genotype,to
R1933 T6536 T6531 prep as,refer
R1934 T6537 T6538 det the,genotype
R1935 T6538 T6536 pobj genotype,as
R1936 T6539 T6538 punct """",genotype
R1937 T6540 T6538 nmod rescue,genotype
R1938 T6541 T6538 punct """",genotype
R1939 T6542 T6531 punct ),refer
R1940 T6543 T6493 punct .,resulted
R1941 T6545 T6546 mark If,were
R1942 T6546 T6558 advcl were,survive
R1943 T6547 T6548 poss our,strategy
R1944 T6548 T6546 nsubj strategy,were
R1945 T6549 T6548 prep for,strategy
R1946 T6550 T6549 pcomp rescuing,for
R1947 T6551 T6552 det the,phenotype
R1948 T6552 T6550 dobj phenotype,rescuing
R1949 T6553 T6552 amod neonatal,phenotype
R1950 T6554 T6552 amod lethal,phenotype
R1951 T6555 T6552 prep of,phenotype
R1952 T6556 T6557 det the,knockout
R1953 T6557 T6555 pobj knockout,of
R1954 T6559 T6546 acomp successful,were
R1955 T6560 T6558 punct ", ",survive
R1956 T6561 T6558 advmod then,survive
R1957 T6562 T6563 det those,animals
R1958 T6563 T6558 nsubj animals,survive
R1959 T6564 T6563 amod homozygous,animals
R1960 T6565 T6563 compound knockout,animals
R1961 T6566 T6567 dep that,had
R1962 T6567 T6563 relcl had,animals
R1963 T6568 T6569 det both,transgenes
R1964 T6569 T6567 dobj transgenes,had
R1965 T6570 T6558 aux would,survive
R1966 T6571 T6558 prep beyond,survive
R1967 T6572 T6573 det the,period
R1968 T6573 T6571 pobj period,beyond
R1969 T6574 T6573 amod neonatal,period
R1970 T6575 T6558 punct .,survive

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6401 32-38 NCBITaxon:39107 denotes murine
T6402 61-63 PR_EXT:000006300 denotes E2
T6403 64-74 SO_EXT:transgenic_entity denotes transgenic
T6404 95-100 GO:0007618 denotes mated
T6405 118-122 NCBITaxon:10088 denotes mice
T6406 159-161 PR_EXT:000006300 denotes E2
T6407 179-182 PR_EXT:000005308 denotes LAP
T6408 187-196 SO_EXT:0000902 denotes transgene
T6409 198-200 SO_EXT:transgenic_entity denotes Tg
T6410 307-315 GO_EXT:breeding denotes breeding
T6411 319-326 NCBITaxon:33208 denotes animals
T6412 359-369 SO_EXT:0000902 denotes transgenes
T6413 417-421 NCBITaxon:10088 denotes mice
T6414 440-449 SO_EXT:genotype_or_entity_with_genotype denotes genotypes
T6415 465-472 NCBITaxon:33208 denotes animals
T6416 538-548 SO_EXT:0000902 denotes transgenes
T6417 567-575 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6418 584-590 SO_EXT:sequence_rescue_process denotes rescue
T6419 592-600 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6420 623-631 SO_EXT:sequence_rescue_process denotes rescuing
T6421 636-644 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T6422 645-651 GO_EXT:fatality_or_lethality denotes lethal
T6423 726-733 NCBITaxon:33208 denotes animals
T6424 748-758 SO_EXT:0000902 denotes transgenes
T6425 784-799 UBERON:0007221 denotes neonatal period

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T6386 32-38 NCBITaxon:39107 denotes murine
T6387 61-63 PR:000006300 denotes E2
T6388 95-100 GO:0007618 denotes mated
T6389 118-122 NCBITaxon:10088 denotes mice
T6390 159-161 PR:000006300 denotes E2
T6391 179-182 PR:000005308 denotes LAP
T6392 187-196 SO:0000902 denotes transgene
T6393 319-326 NCBITaxon:33208 denotes animals
T6394 359-369 SO:0000902 denotes transgenes
T6395 417-421 NCBITaxon:10088 denotes mice
T6396 465-472 NCBITaxon:33208 denotes animals
T6397 538-548 SO:0000902 denotes transgenes
T6398 726-733 NCBITaxon:33208 denotes animals
T6399 748-758 SO:0000902 denotes transgenes
T6400 784-799 UBERON:0007221 denotes neonatal period