PMC:1420271 / 12728-13168 JSONTXT

{"project":"craft-ca-core-dev","denotations":[{"id":"T13911","span":{"begin":0,"end":4},"obj":"SO:0000704"},{"id":"T13912","span":{"begin":0,"end":15},"obj":"GO:0010467"},{"id":"T13913","span":{"begin":28,"end":32},"obj":"PR:000006847"},{"id":"T13914","span":{"begin":38,"end":46},"obj":"CL:0002322"},{"id":"T13915","span":{"begin":101,"end":109},"obj":"CL:0002322"},{"id":"T13916","span":{"begin":114,"end":118},"obj":"PR:000006847"},{"id":"T13917","span":{"begin":124,"end":132},"obj":"CL:0002322"},{"id":"T13918","span":{"begin":151,"end":154},"obj":"CHEBI:37987"},{"id":"T13919","span":{"begin":159,"end":162},"obj":"CHEBI:37989"},{"id":"T13920","span":{"begin":191,"end":201},"obj":"GO:0097617"},{"id":"T13921","span":{"begin":213,"end":218},"obj":"NCBITaxon:10088"},{"id":"T13922","span":{"begin":340,"end":344},"obj":"PR:000006847"},{"id":"T13923","span":{"begin":352,"end":356},"obj":"PR:000006847"},{"id":"T13924","span":{"begin":384,"end":394},"obj":"GO:0010467"},{"id":"T13925","span":{"begin":398,"end":402},"obj":"PR:000006847"},{"id":"T13926","span":{"begin":404,"end":408},"obj":"PR:000013044"},{"id":"T13927","span":{"begin":415,"end":419},"obj":"PR:000005257"}],"text":"Gene expression analyses of ESG1-null ES cells. A) DNA microarray analyses. Total RNA from wild-type ES cells and ESG1-null ES cells were labeled with Cy3 and Cy5, respectively. Samples were hybridized to Agilent Mouse Developmental Microarrays. The averages of two independent clones are shown. B) Western blot analyses. Cell lysates from ESG1+/- and ESG1-/- cells were examined for expression of ESG1, Oct3/4 and CDK4 with immunoblotting."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T13928","span":{"begin":0,"end":4},"obj":"SO_EXT:0000704"},{"id":"T13929","span":{"begin":0,"end":15},"obj":"GO:0010467"},{"id":"T13930","span":{"begin":28,"end":32},"obj":"PR_EXT:000006847"},{"id":"T13931","span":{"begin":33,"end":37},"obj":"SO_EXT:sequence_nullness"},{"id":"T13932","span":{"begin":38,"end":46},"obj":"CL:0002322"},{"id":"T13933","span":{"begin":41,"end":46},"obj":"CL_GO_EXT:cell"},{"id":"T13934","span":{"begin":51,"end":54},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T13935","span":{"begin":82,"end":85},"obj":"CHEBI_SO_EXT:RNA"},{"id":"T13936","span":{"begin":91,"end":100},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T13937","span":{"begin":101,"end":109},"obj":"CL:0002322"},{"id":"T13938","span":{"begin":104,"end":109},"obj":"CL_GO_EXT:cell"},{"id":"T13939","span":{"begin":114,"end":118},"obj":"PR_EXT:000006847"},{"id":"T13940","span":{"begin":119,"end":123},"obj":"SO_EXT:sequence_nullness"},{"id":"T13941","span":{"begin":124,"end":132},"obj":"CL:0002322"},{"id":"T13942","span":{"begin":127,"end":132},"obj":"CL_GO_EXT:cell"},{"id":"T13943","span":{"begin":138,"end":145},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T13944","span":{"begin":151,"end":154},"obj":"CHEBI:37987"},{"id":"T13945","span":{"begin":159,"end":162},"obj":"CHEBI:37989"},{"id":"T13946","span":{"begin":191,"end":201},"obj":"GO:0097617"},{"id":"T13947","span":{"begin":213,"end":218},"obj":"NCBITaxon:10088"},{"id":"T13948","span":{"begin":278,"end":284},"obj":"SO_EXT:sequence_cloned_entity"},{"id":"T13949","span":{"begin":322,"end":326},"obj":"CL_GO_EXT:cell"},{"id":"T13950","span":{"begin":340,"end":344},"obj":"PR_EXT:000006847"},{"id":"T13951","span":{"begin":344,"end":345},"obj":"SO_EXT:normal_or_wild_type_or_present"},{"id":"T13952","span":{"begin":346,"end":347},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T13953","span":{"begin":352,"end":356},"obj":"PR_EXT:000006847"},{"id":"T13954","span":{"begin":356,"end":357},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T13955","span":{"begin":358,"end":359},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T13956","span":{"begin":360,"end":365},"obj":"CL_GO_EXT:cell"},{"id":"T13957","span":{"begin":384,"end":394},"obj":"GO:0010467"},{"id":"T13958","span":{"begin":398,"end":402},"obj":"PR_EXT:000006847"},{"id":"T13959","span":{"begin":404,"end":408},"obj":"PR_EXT:000013044"},{"id":"T13960","span":{"begin":415,"end":419},"obj":"PR_EXT:000005257"}],"text":"Gene expression analyses of ESG1-null ES cells. A) DNA microarray analyses. Total RNA from wild-type ES cells and ESG1-null ES cells were labeled with Cy3 and Cy5, respectively. Samples were hybridized to Agilent Mouse Developmental Microarrays. The averages of two independent clones are shown. B) Western blot analyses. Cell lysates from ESG1+/- and ESG1-/- cells were examined for expression of ESG1, Oct3/4 and CDK4 with immunoblotting."}

{"project":"craft-sa-dev","denotations":[{"id":"T13961","span":{"begin":0,"end":4},"obj":"NN"},{"id":"T13962","span":{"begin":5,"end":15},"obj":"NN"},{"id":"T13963","span":{"begin":16,"end":24},"obj":"NNS"},{"id":"T13964","span":{"begin":25,"end":27},"obj":"IN"},{"id":"T13965","span":{"begin":28,"end":32},"obj":"NN"},{"id":"T13966","span":{"begin":33,"end":37},"obj":"JJ"},{"id":"T13967","span":{"begin":32,"end":33},"obj":"HYPH"},{"id":"T13968","span":{"begin":41,"end":46},"obj":"NNS"},{"id":"T13969","span":{"begin":38,"end":40},"obj":"NN"},{"id":"T13970","span":{"begin":46,"end":47},"obj":"."},{"id":"T13971","span":{"begin":47,"end":75},"obj":"sentence"},{"id":"T13972","span":{"begin":48,"end":49},"obj":"LS"},{"id":"T13973","span":{"begin":66,"end":74},"obj":"NNS"},{"id":"T13974","span":{"begin":49,"end":50},"obj":"-RRB-"},{"id":"T13975","span":{"begin":51,"end":54},"obj":"NN"},{"id":"T13976","span":{"begin":55,"end":65},"obj":"NN"},{"id":"T13977","span":{"begin":74,"end":75},"obj":"."},{"id":"T13978","span":{"begin":75,"end":177},"obj":"sentence"},{"id":"T13979","span":{"begin":76,"end":81},"obj":"JJ"},{"id":"T13980","span":{"begin":82,"end":85},"obj":"NN"},{"id":"T13981","span":{"begin":138,"end":145},"obj":"VBN"},{"id":"T13982","span":{"begin":86,"end":90},"obj":"IN"},{"id":"T13983","span":{"begin":91,"end":95},"obj":"JJ"},{"id":"T13984","span":{"begin":96,"end":100},"obj":"NN"},{"id":"T13985","span":{"begin":95,"end":96},"obj":"HYPH"},{"id":"T13986","span":{"begin":104,"end":109},"obj":"NNS"},{"id":"T13987","span":{"begin":101,"end":103},"obj":"NN"},{"id":"T13988","span":{"begin":110,"end":113},"obj":"CC"},{"id":"T13989","span":{"begin":114,"end":118},"obj":"NN"},{"id":"T13990","span":{"begin":119,"end":123},"obj":"JJ"},{"id":"T13991","span":{"begin":118,"end":119},"obj":"HYPH"},{"id":"T13992","span":{"begin":127,"end":132},"obj":"NNS"},{"id":"T13993","span":{"begin":124,"end":126},"obj":"NN"},{"id":"T13994","span":{"begin":133,"end":137},"obj":"VBD"},{"id":"T13995","span":{"begin":146,"end":150},"obj":"IN"},{"id":"T13996","span":{"begin":151,"end":154},"obj":"NN"},{"id":"T13997","span":{"begin":155,"end":158},"obj":"CC"},{"id":"T13998","span":{"begin":159,"end":162},"obj":"NN"},{"id":"T13999","span":{"begin":162,"end":164},"obj":","},{"id":"T14000","span":{"begin":164,"end":176},"obj":"RB"},{"id":"T14001","span":{"begin":176,"end":177},"obj":"."},{"id":"T14002","span":{"begin":177,"end":245},"obj":"sentence"},{"id":"T14003","span":{"begin":178,"end":185},"obj":"NNS"},{"id":"T14004","span":{"begin":191,"end":201},"obj":"VBN"},{"id":"T14005","span":{"begin":186,"end":190},"obj":"VBD"},{"id":"T14006","span":{"begin":202,"end":204},"obj":"IN"},{"id":"T14007","span":{"begin":205,"end":212},"obj":"NNP"},{"id":"T14008","span":{"begin":233,"end":244},"obj":"NNS"},{"id":"T14009","span":{"begin":213,"end":218},"obj":"NN"},{"id":"T14010","span":{"begin":219,"end":232},"obj":"JJ"},{"id":"T14011","span":{"begin":244,"end":245},"obj":"."},{"id":"T14012","span":{"begin":245,"end":295},"obj":"sentence"},{"id":"T14013","span":{"begin":246,"end":249},"obj":"DT"},{"id":"T14014","span":{"begin":250,"end":258},"obj":"NNS"},{"id":"T14015","span":{"begin":289,"end":294},"obj":"VBN"},{"id":"T14016","span":{"begin":259,"end":261},"obj":"IN"},{"id":"T14017","span":{"begin":262,"end":265},"obj":"CD"},{"id":"T14018","span":{"begin":278,"end":284},"obj":"NNS"},{"id":"T14019","span":{"begin":266,"end":277},"obj":"JJ"},{"id":"T14020","span":{"begin":285,"end":288},"obj":"VBP"},{"id":"T14021","span":{"begin":294,"end":295},"obj":"."},{"id":"T14022","span":{"begin":295,"end":321},"obj":"sentence"},{"id":"T14023","span":{"begin":296,"end":297},"obj":"LS"},{"id":"T14024","span":{"begin":312,"end":320},"obj":"NNS"},{"id":"T14025","span":{"begin":297,"end":298},"obj":"-RRB-"},{"id":"T14026","span":{"begin":299,"end":306},"obj":"NNP"},{"id":"T14027","span":{"begin":307,"end":311},"obj":"NN"},{"id":"T14028","span":{"begin":320,"end":321},"obj":"."},{"id":"T14029","span":{"begin":321,"end":440},"obj":"sentence"},{"id":"T14030","span":{"begin":322,"end":326},"obj":"NN"},{"id":"T14031","span":{"begin":327,"end":334},"obj":"NNS"},{"id":"T14032","span":{"begin":371,"end":379},"obj":"VBN"},{"id":"T14033","span":{"begin":335,"end":339},"obj":"IN"},{"id":"T14034","span":{"begin":340,"end":344},"obj":"NN"},{"id":"T14035","span":{"begin":360,"end":365},"obj":"NNS"},{"id":"T14036","span":{"begin":344,"end":345},"obj":"SYM"},{"id":"T14037","span":{"begin":345,"end":346},"obj":"HYPH"},{"id":"T14038","span":{"begin":346,"end":347},"obj":"SYM"},{"id":"T14039","span":{"begin":348,"end":351},"obj":"CC"},{"id":"T14040","span":{"begin":352,"end":356},"obj":"NN"},{"id":"T14041","span":{"begin":356,"end":357},"obj":"SYM"},{"id":"T14042","span":{"begin":357,"end":358},"obj":"HYPH"},{"id":"T14043","span":{"begin":358,"end":359},"obj":"SYM"},{"id":"T14044","span":{"begin":366,"end":370},"obj":"VBD"},{"id":"T14045","span":{"begin":380,"end":383},"obj":"IN"},{"id":"T14046","span":{"begin":384,"end":394},"obj":"NN"},{"id":"T14047","span":{"begin":395,"end":397},"obj":"IN"},{"id":"T14048","span":{"begin":398,"end":402},"obj":"NN"},{"id":"T14049","span":{"begin":402,"end":404},"obj":","},{"id":"T14050","span":{"begin":404,"end":408},"obj":"NN"},{"id":"T14051","span":{"begin":408,"end":409},"obj":"HYPH"},{"id":"T14052","span":{"begin":409,"end":410},"obj":"CD"},{"id":"T14053","span":{"begin":411,"end":414},"obj":"CC"},{"id":"T14054","span":{"begin":415,"end":419},"obj":"NN"},{"id":"T14055","span":{"begin":420,"end":424},"obj":"IN"},{"id":"T14056","span":{"begin":425,"end":439},"obj":"NN"},{"id":"T14057","span":{"begin":439,"end":440},"obj":"."}],"relations":[{"id":"R3959","pred":"compound","subj":"T13961","obj":"T13962"},{"id":"R3960","pred":"compound","subj":"T13962","obj":"T13963"},{"id":"R3961","pred":"prep","subj":"T13964","obj":"T13963"},{"id":"R3962","pred":"npadvmod","subj":"T13965","obj":"T13966"},{"id":"R3963","pred":"amod","subj":"T13966","obj":"T13968"},{"id":"R3964","pred":"punct","subj":"T13967","obj":"T13966"},{"id":"R3965","pred":"pobj","subj":"T13968","obj":"T13964"},{"id":"R3966","pred":"compound","subj":"T13969","obj":"T13968"},{"id":"R3967","pred":"punct","subj":"T13970","obj":"T13963"},{"id":"R3968","pred":"meta","subj":"T13972","obj":"T13973"},{"id":"R3969","pred":"punct","subj":"T13974","obj":"T13972"},{"id":"R3970","pred":"compound","subj":"T13975","obj":"T13973"},{"id":"R3971","pred":"compound","subj":"T13976","obj":"T13973"},{"id":"R3972","pred":"punct","subj":"T13977","obj":"T13973"},{"id":"R3973","pred":"amod","subj":"T13979","obj":"T13980"},{"id":"R3974","pred":"nsubjpass","subj":"T13980","obj":"T13981"},{"id":"R3975","pred":"prep","subj":"T13982","obj":"T13980"},{"id":"R3976","pred":"amod","subj":"T13983","obj":"T13984"},{"id":"R3977","pred":"compound","subj":"T13984","obj":"T13986"},{"id":"R3978","pred":"punct","subj":"T13985","obj":"T13984"},{"id":"R3979","pred":"pobj","subj":"T13986","obj":"T13982"},{"id":"R3980","pred":"compound","subj":"T13987","obj":"T13986"},{"id":"R3981","pred":"cc","subj":"T13988","obj":"T13986"},{"id":"R3982","pred":"npadvmod","subj":"T13989","obj":"T13990"},{"id":"R3983","pred":"amod","subj":"T13990","obj":"T13992"},{"id":"R3984","pred":"punct","subj":"T13991","obj":"T13990"},{"id":"R3985","pred":"conj","subj":"T13992","obj":"T13986"},{"id":"R3986","pred":"compound","subj":"T13993","obj":"T13992"},{"id":"R3987","pred":"auxpass","subj":"T13994","obj":"T13981"},{"id":"R3988","pred":"prep","subj":"T13995","obj":"T13981"},{"id":"R3989","pred":"pobj","subj":"T13996","obj":"T13995"},{"id":"R3990","pred":"cc","subj":"T13997","obj":"T13996"},{"id":"R3991","pred":"conj","subj":"T13998","obj":"T13996"},{"id":"R3992","pred":"punct","subj":"T13999","obj":"T13981"},{"id":"R3993","pred":"advmod","subj":"T14000","obj":"T13981"},{"id":"R3994","pred":"punct","subj":"T14001","obj":"T13981"},{"id":"R3995","pred":"nsubjpass","subj":"T14003","obj":"T14004"},{"id":"R3996","pred":"auxpass","subj":"T14005","obj":"T14004"},{"id":"R3997","pred":"prep","subj":"T14006","obj":"T14004"},{"id":"R3998","pred":"nmod","subj":"T14007","obj":"T14008"},{"id":"R3999","pred":"pobj","subj":"T14008","obj":"T14006"},{"id":"R4000","pred":"nmod","subj":"T14009","obj":"T14008"},{"id":"R4001","pred":"amod","subj":"T14010","obj":"T14008"},{"id":"R4002","pred":"punct","subj":"T14011","obj":"T14004"},{"id":"R4003","pred":"det","subj":"T14013","obj":"T14014"},{"id":"R4004","pred":"nsubjpass","subj":"T14014","obj":"T14015"},{"id":"R4005","pred":"prep","subj":"T14016","obj":"T14014"},{"id":"R4006","pred":"nummod","subj":"T14017","obj":"T14018"},{"id":"R4007","pred":"pobj","subj":"T14018","obj":"T14016"},{"id":"R4008","pred":"amod","subj":"T14019","obj":"T14018"},{"id":"R4009","pred":"auxpass","subj":"T14020","obj":"T14015"},{"id":"R4010","pred":"punct","subj":"T14021","obj":"T14015"},{"id":"R4011","pred":"meta","subj":"T14023","obj":"T14024"},{"id":"R4012","pred":"punct","subj":"T14025","obj":"T14023"},{"id":"R4013","pred":"compound","subj":"T14026","obj":"T14027"},{"id":"R4014","pred":"compound","subj":"T14027","obj":"T14024"},{"id":"R4015","pred":"punct","subj":"T14028","obj":"T14024"},{"id":"R4016","pred":"compound","subj":"T14030","obj":"T14031"},{"id":"R4017","pred":"nsubjpass","subj":"T14031","obj":"T14032"},{"id":"R4018","pred":"prep","subj":"T14033","obj":"T14031"},{"id":"R4019","pred":"nmod","subj":"T14034","obj":"T14035"},{"id":"R4020","pred":"pobj","subj":"T14035","obj":"T14033"},{"id":"R4021","pred":"punct","subj":"T14036","obj":"T14034"},{"id":"R4022","pred":"punct","subj":"T14037","obj":"T14034"},{"id":"R4023","pred":"punct","subj":"T14038","obj":"T14034"},{"id":"R4024","pred":"cc","subj":"T14039","obj":"T14034"},{"id":"R4025","pred":"conj","subj":"T14040","obj":"T14034"},{"id":"R4026","pred":"punct","subj":"T14041","obj":"T14040"},{"id":"R4027","pred":"punct","subj":"T14042","obj":"T14040"},{"id":"R4028","pred":"punct","subj":"T14043","obj":"T14040"},{"id":"R4029","pred":"auxpass","subj":"T14044","obj":"T14032"},{"id":"R4030","pred":"prep","subj":"T14045","obj":"T14032"},{"id":"R4031","pred":"pobj","subj":"T14046","obj":"T14045"},{"id":"R4032","pred":"prep","subj":"T14047","obj":"T14046"},{"id":"R4033","pred":"pobj","subj":"T14048","obj":"T14047"},{"id":"R4034","pred":"punct","subj":"T14049","obj":"T14048"},{"id":"R4035","pred":"conj","subj":"T14050","obj":"T14048"},{"id":"R4036","pred":"punct","subj":"T14051","obj":"T14050"},{"id":"R4037","pred":"nummod","subj":"T14052","obj":"T14050"},{"id":"R4038","pred":"cc","subj":"T14053","obj":"T14050"},{"id":"R4039","pred":"conj","subj":"T14054","obj":"T14050"},{"id":"R4040","pred":"prep","subj":"T14055","obj":"T14032"},{"id":"R4041","pred":"pobj","subj":"T14056","obj":"T14055"},{"id":"R4042","pred":"punct","subj":"T14057","obj":"T14032"}],"text":"Gene expression analyses of ESG1-null ES cells. A) DNA microarray analyses. Total RNA from wild-type ES cells and ESG1-null ES cells were labeled with Cy3 and Cy5, respectively. Samples were hybridized to Agilent Mouse Developmental Microarrays. The averages of two independent clones are shown. B) Western blot analyses. Cell lysates from ESG1+/- and ESG1-/- cells were examined for expression of ESG1, Oct3/4 and CDK4 with immunoblotting."}