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PMC:1420271 / 100-1851 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T627 11-20 UBERON:0000922 denotes Embryonic
T628 11-30 CL:0002322 denotes Embryonic stem cell
T629 11-44 _FRAGMENT denotes Embryonic stem cell-specific gene
T630 51-52 PR:000006847 denotes 1
T631 40-44 SO:0000704 denotes gene
T632 46-49 _FRAGMENT denotes ESG
T633 73-79 SO:0000417 denotes domain
T634 116-125 GO:0010467 denotes expressed
T635 129-142 UBERON:0019248 denotes early embryos
T636 144-154 CL:0000586 denotes germ cells
T637 160-169 UBERON:0000922 denotes embryonic
T638 160-174 _FRAGMENT denotes embryonic stem
T639 180-185 CL:0002322 denotes cells
T640 176-178 _FRAGMENT denotes ES
T641 215-229 SO:0000040 denotes genomic clones
T642 245-250 NCBITaxon:10088 denotes mouse
T643 251-255 PR:000006847 denotes ESG1
T644 256-260 SO:0000704 denotes gene
T645 270-281 SO:0000336 denotes pseudogenes
T646 404-409 NCBITaxon:10088 denotes mouse
T647 410-417 SO:0001026 denotes genomic
T648 449-453 PR:000006847 denotes ESG1
T649 454-458 SO:0000704 denotes gene
T650 482-491 NCBITaxon:2 denotes bacterial
T651 525-530 NCBITaxon:10088 denotes mouse
T652 531-535 PR:000006847 denotes ESG1
T653 536-540 SO:0000704 denotes gene
T654 559-563 PR:000006847 denotes ESG1
T655 593-597 SO:0000704 denotes gene
T656 631-635 PR:000006847 denotes ESG1
T657 727-737 SO:0000336 denotes pseudogene
T658 743-761 SO:0001416 denotes 5' flanking region
T659 769-773 PR:000006847 denotes ESG1
T660 774-778 SO:0000704 denotes gene
T661 800-810 SO:0000336 denotes pseudogene
T662 829-837 SO:0000165 denotes enhancer
T663 842-850 SO:0000167 denotes promoter
T664 880-888 CL:0002322 denotes ES cells
T665 963-967 PR:000006847 denotes ESG1
T666 968-972 SO:0000704 denotes gene
T667 1003-1011 CL:0002322 denotes ES cells
T668 1025-1033 SO:0005853 denotes cassette
T669 1080-1090 GO:0010467 denotes expression
T670 1094-1107 UBERON:0019248 denotes early embryos
T671 1112-1122 CL:0000586 denotes germ cells
T672 1124-1128 PR:000006847 denotes ESG1
T673 1132-1136 NCBITaxon:10088 denotes mice
T674 1192-1196 PR:000006847 denotes ESG1
T675 1200-1208 CL:0002322 denotes ES cells
T676 1281-1292 UBERON:0000358 denotes blastocysts
T677 1398-1402 PR:000006847 denotes ESG1
T678 1425-1433 CL:0002322 denotes ES cells
T679 1466-1479 GO:0008283 denotes proliferation
T680 1518-1523 NCBITaxon:10088 denotes mouse
T681 1524-1528 PR:000006847 denotes ESG1
T682 1529-1533 SO:0000704 denotes gene
T683 1562-1572 SO:0000336 denotes pseudogene
T684 1623-1633 GO:0010467 denotes expression
T685 1659-1669 CL:0000586 denotes germ cells
T686 1671-1675 PR:000006847 denotes ESG1
T687 1695-1710 _FRAGMENT denotes self-renewal of
T688 1714-1719 GO:0017145 denotes cells
T689 1711-1719 CL:0002322 denotes ES cells
T690 1724-1750 GO:0007281 denotes establishment of germcells
T691 1741-1750 CL:0000586 denotes germcells
R1 T630 T629 _lexicallyChainedTo 1,Embryonic stem cell-specific gene
R2 T630 T632 _lexicallyChainedTo 1,ESG
R3 T639 T638 _lexicallyChainedTo cells,embryonic stem
R4 T639 T640 _lexicallyChainedTo cells,ES
R5 T688 T687 _lexicallyChainedTo cells,self-renewal of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T699 11-20 UBERON:0000922 denotes Embryonic
T700 11-30 CL:0002322 denotes Embryonic stem cell
T701 11-44 _FRAGMENT denotes Embryonic stem cell-specific gene
T702 51-52 PR_EXT:000006847 denotes 1
T703 26-30 CL_GO_EXT:cell denotes cell
T704 40-44 SO_EXT:0000704 denotes gene
T705 46-49 _FRAGMENT denotes ESG
T706 60-67 SO_EXT:sequence_coding_function denotes encodes
T707 73-79 SO_EXT:0000417 denotes domain
T708 91-98 CHEBI_PR_EXT:protein denotes protein
T709 116-125 GO:0010467 denotes expressed
T710 129-142 UBERON:0019248 denotes early embryos
T711 144-154 CL:0000586 denotes germ cells
T712 149-154 CL_GO_EXT:cell denotes cells
T713 160-169 UBERON:0000922 denotes embryonic
T714 160-174 _FRAGMENT denotes embryonic stem
T715 180-185 CL:0002322 denotes cells
T716 176-178 _FRAGMENT denotes ES
T717 180-185 CL_GO_EXT:cell denotes cells
T718 215-229 SO_EXT:0000040 denotes genomic clones
T719 245-250 NCBITaxon:10088 denotes mouse
T720 251-255 PR_EXT:000006847 denotes ESG1
T721 256-260 SO_EXT:0000704 denotes gene
T722 270-281 SO_EXT:0000336 denotes pseudogenes
T723 298-309 GO_SO_EXT:chromosome denotes chromosomal
T724 310-323 GO_PATO_EXT:biological_localization_process_or_quality denotes localizations
T725 327-340 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T726 404-409 NCBITaxon:10088 denotes mouse
T727 410-417 SO_EXT:0001026 denotes genomic
T728 449-453 PR_EXT:000006847 denotes ESG1
T729 454-458 SO_EXT:0000704 denotes gene
T730 482-491 NCBITaxon:2 denotes bacterial
T731 503-509 SO_EXT:sequence_cloned_entity denotes clones
T732 525-530 NCBITaxon:10088 denotes mouse
T733 531-535 PR_EXT:000006847 denotes ESG1
T734 536-540 SO_EXT:0000704 denotes gene
T735 559-563 PR_EXT:000006847 denotes ESG1
T736 569-577 SO_EXT:biological_sequence denotes sequence
T737 593-597 SO_EXT:0000704 denotes gene
T738 613-623 GO_SO_EXT:chromosome denotes chromosome
T739 631-635 PR_EXT:000006847 denotes ESG1
T740 641-649 SO_EXT:biological_sequence denotes sequence
T741 680-689 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T742 716-726 SO_EXT:sequence_duplication_process denotes duplicated
T743 727-737 SO_EXT:0000336 denotes pseudogene
T744 743-761 SO_EXT:0001416 denotes 5' flanking region
T745 769-773 PR_EXT:000006847 denotes ESG1
T746 774-778 SO_EXT:0000704 denotes gene
T747 800-810 SO_EXT:0000336 denotes pseudogene
T748 829-837 SO_EXT:0000165 denotes enhancer
T749 842-850 SO_EXT:0000167 denotes promoter
T750 865-879 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T751 880-888 CL:0002322 denotes ES cells
T752 883-888 CL_GO_EXT:cell denotes cells
T753 892-902 GO_EXT:0045289 denotes luciferase
T754 932-945 GO_PATO_EXT:physiological_process_or_quality denotes physiological
T755 963-967 PR_EXT:000006847 denotes ESG1
T756 968-972 SO_EXT:0000704 denotes gene
T757 977-985 SO_EXT:sequence_substitution_process denotes replaced
T758 991-999 SO_EXT:biological_sequence denotes sequence
T759 1003-1011 CL:0002322 denotes ES cells
T760 1006-1011 CL_GO_EXT:cell denotes cells
T761 1019-1024 GO_EXT:beta_geo denotes β-geo
T762 1025-1033 SO_EXT:0005853 denotes cassette
T763 1048-1061 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T764 1080-1090 GO:0010467 denotes expression
T765 1094-1107 UBERON:0019248 denotes early embryos
T766 1112-1122 CL:0000586 denotes germ cells
T767 1117-1122 CL_GO_EXT:cell denotes cells
T768 1124-1128 PR_EXT:000006847 denotes ESG1
T769 1128-1129 SO_EXT:sequence_nullness_or_absence denotes -
T770 1130-1131 SO_EXT:sequence_nullness_or_absence denotes -
T771 1132-1136 NCBITaxon:10088 denotes mice
T772 1192-1196 PR_EXT:000006847 denotes ESG1
T773 1196-1197 SO_EXT:sequence_nullness_or_absence denotes -
T774 1198-1199 SO_EXT:sequence_nullness_or_absence denotes -
T775 1200-1208 CL:0002322 denotes ES cells
T776 1203-1208 CL_GO_EXT:cell denotes cells
T777 1249-1262 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T778 1281-1292 UBERON:0000358 denotes blastocysts
T779 1398-1402 PR_EXT:000006847 denotes ESG1
T780 1412-1417 CL_GO_EXT:cell denotes cells
T781 1425-1433 CL:0002322 denotes ES cells
T782 1428-1433 CL_GO_EXT:cell denotes cells
T783 1466-1479 GO:0008283 denotes proliferation
T784 1485-1500 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T785 1518-1523 NCBITaxon:10088 denotes mouse
T786 1524-1528 PR_EXT:000006847 denotes ESG1
T787 1529-1533 SO_EXT:0000704 denotes gene
T788 1551-1561 SO_EXT:sequence_duplication_process denotes duplicated
T789 1562-1572 SO_EXT:0000336 denotes pseudogene
T790 1588-1598 GO_SO_EXT:chromosome denotes chromosome
T791 1623-1633 GO:0010467 denotes expression
T792 1649-1654 CL_GO_EXT:cell denotes cells
T793 1659-1669 CL:0000586 denotes germ cells
T794 1664-1669 CL_GO_EXT:cell denotes cells
T795 1671-1675 PR_EXT:000006847 denotes ESG1
T796 1695-1710 _FRAGMENT denotes self-renewal of
T797 1714-1719 GO:0017145 denotes cells
T798 1711-1719 CL:0002322 denotes ES cells
T799 1714-1719 CL_GO_EXT:cell denotes cells
T800 1724-1750 GO:0007281 denotes establishment of germcells
T801 1741-1750 CL:0000586 denotes germcells
R6 T702 T701 _lexicallyChainedTo 1,Embryonic stem cell-specific gene
R7 T702 T705 _lexicallyChainedTo 1,ESG
R8 T715 T714 _lexicallyChainedTo cells,embryonic stem
R9 T715 T716 _lexicallyChainedTo cells,ES
R10 T797 T796 _lexicallyChainedTo cells,self-renewal of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T821 0-10 sentence denotes Background
T822 0-10 NN denotes Background
T823 10-186 sentence denotes Embryonic stem cell-specific gene (ESG) 1, which encodes a KH-domain containing protein, is specifically expressed in early embryos, germ cells, and embryonic stem (ES) cells.
T824 11-20 JJ denotes Embryonic
T825 26-30 NN denotes cell
T826 21-25 NN denotes stem
T827 31-39 JJ denotes specific
T828 30-31 HYPH denotes -
T829 40-44 NN denotes gene
T830 116-125 VBN denotes expressed
T831 45-46 -LRB- denotes (
T832 46-49 NN denotes ESG
T833 49-50 -RRB- denotes )
T834 51-52 CD denotes 1
T835 52-54 , denotes ,
T836 54-59 WDT denotes which
T837 60-67 VBZ denotes encodes
T838 68-69 DT denotes a
T839 91-98 NN denotes protein
T840 70-72 NN denotes KH
T841 73-79 NN denotes domain
T842 72-73 HYPH denotes -
T843 80-90 VBG denotes containing
T844 98-100 , denotes ,
T845 100-102 VBZ denotes is
T846 103-115 RB denotes specifically
T847 126-128 IN denotes in
T848 129-134 JJ denotes early
T849 135-142 NNS denotes embryos
T850 142-144 , denotes ,
T851 144-148 NN denotes germ
T852 149-154 NNS denotes cells
T853 154-156 , denotes ,
T854 156-159 CC denotes and
T855 160-169 JJ denotes embryonic
T856 170-174 NN denotes stem
T857 180-185 NNS denotes cells
T858 175-176 -LRB- denotes (
T859 176-178 NN denotes ES
T860 178-179 -RRB- denotes )
T861 185-186 . denotes .
T862 186-282 sentence denotes Previous studies identified genomic clones containing the mouse ESG1 gene and five pseudogenes.
T863 187-195 JJ denotes Previous
T864 196-203 NNS denotes studies
T865 204-214 VBD denotes identified
T866 215-222 JJ denotes genomic
T867 223-229 NNS denotes clones
T868 230-240 VBG denotes containing
T869 241-244 DT denotes the
T870 256-260 NN denotes gene
T871 245-250 NN denotes mouse
T872 251-255 NN denotes ESG1
T873 261-264 CC denotes and
T874 265-269 CD denotes five
T875 270-281 NNS denotes pseudogenes
T876 281-282 . denotes .
T877 282-376 sentence denotes However, their chromosomal localizations or physiological functions have not been determined.
T878 283-290 RB denotes However
T879 365-375 VBN denotes determined
T880 290-292 , denotes ,
T881 292-297 PRP$ denotes their
T882 310-323 NNS denotes localizations
T883 298-309 JJ denotes chromosomal
T884 324-326 CC denotes or
T885 327-340 JJ denotes physiological
T886 341-350 NNS denotes functions
T887 351-355 VBP denotes have
T888 356-359 RB denotes not
T889 360-364 VBN denotes been
T890 375-376 . denotes .
T891 376-385 sentence denotes Results
T892 378-385 NNS denotes Results
T893 385-459 sentence denotes A Blast search of mouse genomic databases failed to locate the ESG1 gene.
T894 386-387 DT denotes A
T895 394-400 NN denotes search
T896 388-393 NNP denotes Blast
T897 428-434 VBD denotes failed
T898 401-403 IN denotes of
T899 404-409 NN denotes mouse
T900 418-427 NNS denotes databases
T901 410-417 JJ denotes genomic
T902 435-437 TO denotes to
T903 438-444 VB denotes locate
T904 445-448 DT denotes the
T905 454-458 NN denotes gene
T906 449-453 NN denotes ESG1
T907 458-459 . denotes .
T908 459-626 sentence denotes We identified several bacterial artificial clones containing the mouse ESG1 gene and an additional ESG1-like sequence with a similar gene structure from chromosome 9.
T909 460-462 PRP denotes We
T910 463-473 VBD denotes identified
T911 474-481 JJ denotes several
T912 503-509 NNS denotes clones
T913 482-491 JJ denotes bacterial
T914 492-502 JJ denotes artificial
T915 510-520 VBG denotes containing
T916 521-524 DT denotes the
T917 536-540 NN denotes gene
T918 525-530 NN denotes mouse
T919 531-535 NN denotes ESG1
T920 541-544 CC denotes and
T921 545-547 DT denotes an
T922 569-577 NN denotes sequence
T923 548-558 JJ denotes additional
T924 559-563 NN denotes ESG1
T925 564-568 JJ denotes like
T926 563-564 HYPH denotes -
T927 578-582 IN denotes with
T928 583-584 DT denotes a
T929 598-607 NN denotes structure
T930 585-592 JJ denotes similar
T931 593-597 NN denotes gene
T932 608-612 IN denotes from
T933 613-623 NN denotes chromosome
T934 624-625 CD denotes 9
T935 625-626 . denotes .
T936 626-738 sentence denotes The ESG1-like sequence contained a multiple critical mutations, indicating that it was a duplicated pseudogene.
T937 627-630 DT denotes The
T938 641-649 NN denotes sequence
T939 631-635 NN denotes ESG1
T940 636-640 JJ denotes like
T941 635-636 HYPH denotes -
T942 650-659 VBD denotes contained
T943 660-661 DT denotes a
T944 680-689 NNS denotes mutations
T945 662-670 JJ denotes multiple
T946 671-679 JJ denotes critical
T947 689-691 , denotes ,
T948 691-701 VBG denotes indicating
T949 702-706 IN denotes that
T950 710-713 VBD denotes was
T951 707-709 PRP denotes it
T952 714-715 DT denotes a
T953 727-737 NN denotes pseudogene
T954 716-726 VBN denotes duplicated
T955 737-738 . denotes .
T956 738-918 sentence denotes The 5' flanking region of the ESG1 gene, but not that of the pseudogene, exhibited strong enhancer and promoter activity in undifferentiated ES cells by luciferase reporter assay.
T957 739-742 DT denotes The
T958 755-761 NN denotes region
T959 743-744 CD denotes 5
T960 744-745 SYM denotes '
T961 746-754 NN denotes flanking
T962 812-821 VBD denotes exhibited
T963 762-764 IN denotes of
T964 765-768 DT denotes the
T965 774-778 NN denotes gene
T966 769-773 NN denotes ESG1
T967 778-780 , denotes ,
T968 780-783 CC denotes but
T969 784-787 RB denotes not
T970 788-792 DT denotes that
T971 793-795 IN denotes of
T972 796-799 DT denotes the
T973 800-810 NN denotes pseudogene
T974 810-812 , denotes ,
T975 822-828 JJ denotes strong
T976 851-859 NN denotes activity
T977 829-837 NN denotes enhancer
T978 838-841 CC denotes and
T979 842-850 NN denotes promoter
T980 860-862 IN denotes in
T981 863-879 JJ denotes undifferentiated
T982 883-888 NNS denotes cells
T983 880-882 NN denotes ES
T984 889-891 IN denotes by
T985 892-902 NN denotes luciferase
T986 903-911 NN denotes reporter
T987 912-917 NN denotes assay
T988 917-918 . denotes .
T989 918-1062 sentence denotes To study the physiological functions of the ESG1 gene, we replaced this sequence in ES cells with a β-geo cassette by homologous recombination.
T990 919-921 TO denotes To
T991 922-927 VB denotes study
T992 977-985 VBD denotes replaced
T993 928-931 DT denotes the
T994 946-955 NNS denotes functions
T995 932-945 JJ denotes physiological
T996 956-958 IN denotes of
T997 959-962 DT denotes the
T998 968-972 NN denotes gene
T999 963-967 NN denotes ESG1
T1000 972-974 , denotes ,
T1001 974-976 PRP denotes we
T1002 986-990 DT denotes this
T1003 991-999 NN denotes sequence
T1004 1000-1002 IN denotes in
T1005 1003-1005 NN denotes ES
T1006 1006-1011 NNS denotes cells
T1007 1012-1016 IN denotes with
T1008 1017-1018 DT denotes a
T1009 1025-1033 NN denotes cassette
T1010 1019-1020 NN denotes β
T1011 1021-1024 NN denotes geo
T1012 1020-1021 HYPH denotes -
T1013 1034-1036 IN denotes by
T1014 1037-1047 JJ denotes homologous
T1015 1048-1061 NN denotes recombination
T1016 1061-1062 . denotes .
T1017 1062-1173 sentence denotes Despite specific expression in early embryos and germ cells, ESG1-/- mice developed normally and were fertile.
T1018 1063-1070 IN denotes Despite
T1019 1137-1146 VBD denotes developed
T1020 1071-1079 JJ denotes specific
T1021 1080-1090 NN denotes expression
T1022 1091-1093 IN denotes in
T1023 1094-1099 JJ denotes early
T1024 1100-1107 NNS denotes embryos
T1025 1108-1111 CC denotes and
T1026 1112-1116 NN denotes germ
T1027 1117-1122 NNS denotes cells
T1028 1122-1124 , denotes ,
T1029 1124-1128 NN denotes ESG1
T1030 1132-1136 NNS denotes mice
T1031 1128-1129 SYM denotes -
T1032 1129-1130 HYPH denotes /
T1033 1130-1131 SYM denotes -
T1034 1147-1155 RB denotes normally
T1035 1156-1159 CC denotes and
T1036 1160-1164 VBD denotes were
T1037 1165-1172 JJ denotes fertile
T1038 1172-1173 . denotes .
T1039 1173-1332 sentence denotes We also generated ESG1-/- ES cells both by a second independent homologous recombination and directly from blastocysts derived from heterozygous intercrosses.
T1040 1174-1176 PRP denotes We
T1041 1182-1191 VBD denotes generated
T1042 1177-1181 RB denotes also
T1043 1192-1196 NN denotes ESG1
T1044 1203-1208 NNS denotes cells
T1045 1196-1197 SYM denotes -
T1046 1197-1198 HYPH denotes /
T1047 1198-1199 SYM denotes -
T1048 1200-1202 NN denotes ES
T1049 1209-1213 CC denotes both
T1050 1214-1216 IN denotes by
T1051 1217-1218 DT denotes a
T1052 1249-1262 NN denotes recombination
T1053 1219-1225 JJ denotes second
T1054 1226-1237 JJ denotes independent
T1055 1238-1248 JJ denotes homologous
T1056 1263-1266 CC denotes and
T1057 1267-1275 RB denotes directly
T1058 1276-1280 IN denotes from
T1059 1281-1292 NNS denotes blastocysts
T1060 1293-1300 VBN denotes derived
T1061 1301-1305 IN denotes from
T1062 1306-1318 JJ denotes heterozygous
T1063 1319-1331 NNS denotes intercrosses
T1064 1331-1332 . denotes .
T1065 1332-1418 sentence denotes Northern blot and western blot analyses confirmed the absence of ESG1 in these cells.
T1066 1333-1341 NNP denotes Northern
T1067 1342-1346 NN denotes blot
T1068 1364-1372 NNS denotes analyses
T1069 1347-1350 CC denotes and
T1070 1351-1358 NNP denotes western
T1071 1359-1363 NN denotes blot
T1072 1373-1382 VBD denotes confirmed
T1073 1383-1386 DT denotes the
T1074 1387-1394 NN denotes absence
T1075 1395-1397 IN denotes of
T1076 1398-1402 NN denotes ESG1
T1077 1403-1405 IN denotes in
T1078 1406-1411 DT denotes these
T1079 1412-1417 NNS denotes cells
T1080 1417-1418 . denotes .
T1081 1418-1501 sentence denotes These ES cells demonstrated normal morphology, proliferation, and differentiation.
T1082 1419-1424 DT denotes These
T1083 1428-1433 NNS denotes cells
T1084 1425-1427 NN denotes ES
T1085 1434-1446 VBD denotes demonstrated
T1086 1447-1453 JJ denotes normal
T1087 1454-1464 NN denotes morphology
T1088 1464-1466 , denotes ,
T1089 1466-1479 NN denotes proliferation
T1090 1479-1481 , denotes ,
T1091 1481-1484 CC denotes and
T1092 1485-1500 NN denotes differentiation
T1093 1500-1501 . denotes .
T1094 1501-1513 sentence denotes Conclusion
T1095 1503-1513 NN denotes Conclusion
T1096 1513-1601 sentence denotes The mouse ESG1 gene, together with a duplicated pseudogene, is located on chromosome 9.
T1097 1514-1517 DT denotes The
T1098 1529-1533 NN denotes gene
T1099 1518-1523 NN denotes mouse
T1100 1524-1528 NN denotes ESG1
T1101 1577-1584 VBN denotes located
T1102 1533-1535 , denotes ,
T1103 1535-1543 RB denotes together
T1104 1544-1548 IN denotes with
T1105 1549-1550 DT denotes a
T1106 1562-1572 NN denotes pseudogene
T1107 1551-1561 VBN denotes duplicated
T1108 1572-1574 , denotes ,
T1109 1574-1576 VBZ denotes is
T1110 1585-1587 IN denotes on
T1111 1588-1598 NN denotes chromosome
T1112 1599-1600 CD denotes 9
T1113 1600-1601 . denotes .
T1114 1601-1751 sentence denotes Despite its specific expression in pluripotent cells and germ cells, ESG1 is dispensable for self-renewal of ES cells and establishment of germcells.
T1115 1602-1609 IN denotes Despite
T1116 1676-1678 VBZ denotes is
T1117 1610-1613 PRP$ denotes its
T1118 1623-1633 NN denotes expression
T1119 1614-1622 JJ denotes specific
T1120 1634-1636 IN denotes in
T1121 1637-1648 JJ denotes pluripotent
T1122 1649-1654 NNS denotes cells
T1123 1655-1658 CC denotes and
T1124 1659-1663 NN denotes germ
T1125 1664-1669 NNS denotes cells
T1126 1669-1671 , denotes ,
T1127 1671-1675 NN denotes ESG1
T1128 1679-1690 JJ denotes dispensable
T1129 1691-1694 IN denotes for
T1130 1695-1699 NN denotes self
T1131 1700-1707 NN denotes renewal
T1132 1699-1700 HYPH denotes -
T1133 1708-1710 IN denotes of
T1134 1711-1713 NN denotes ES
T1135 1714-1719 NNS denotes cells
T1136 1720-1723 CC denotes and
T1137 1724-1737 NN denotes establishment
T1138 1738-1740 IN denotes of
T1139 1741-1750 NNS denotes germcells
T1140 1750-1751 . denotes .
R27 T824 T825 amod Embryonic,cell
R28 T825 T827 npadvmod cell,specific
R29 T826 T825 compound stem,cell
R30 T827 T829 amod specific,gene
R31 T828 T827 punct -,specific
R32 T829 T830 nsubjpass gene,expressed
R33 T831 T832 punct (,ESG
R34 T832 T829 parataxis ESG,gene
R35 T833 T832 punct ),ESG
R36 T834 T829 nummod 1,gene
R37 T835 T829 punct ", ",gene
R38 T836 T837 dep which,encodes
R39 T837 T829 relcl encodes,gene
R40 T838 T839 det a,protein
R41 T839 T837 dobj protein,encodes
R42 T840 T841 compound KH,domain
R43 T841 T843 npadvmod domain,containing
R44 T842 T841 punct -,domain
R45 T843 T839 amod containing,protein
R46 T844 T830 punct ", ",expressed
R47 T845 T830 auxpass is,expressed
R48 T846 T830 advmod specifically,expressed
R49 T847 T830 prep in,expressed
R50 T848 T849 amod early,embryos
R51 T849 T847 pobj embryos,in
R52 T850 T849 punct ", ",embryos
R53 T851 T852 compound germ,cells
R54 T852 T849 conj cells,embryos
R55 T853 T852 punct ", ",cells
R56 T854 T852 cc and,cells
R57 T855 T856 amod embryonic,stem
R58 T856 T857 nmod stem,cells
R59 T857 T852 conj cells,cells
R60 T858 T856 punct (,stem
R61 T859 T856 appos ES,stem
R62 T860 T857 punct ),cells
R63 T861 T830 punct .,expressed
R64 T863 T864 amod Previous,studies
R65 T864 T865 nsubj studies,identified
R66 T866 T867 amod genomic,clones
R67 T867 T865 dobj clones,identified
R68 T868 T867 acl containing,clones
R69 T869 T870 det the,gene
R70 T870 T868 dobj gene,containing
R71 T871 T870 compound mouse,gene
R72 T872 T870 compound ESG1,gene
R73 T873 T870 cc and,gene
R74 T874 T875 nummod five,pseudogenes
R75 T875 T870 conj pseudogenes,gene
R76 T876 T865 punct .,identified
R77 T878 T879 advmod However,determined
R78 T880 T879 punct ", ",determined
R79 T881 T882 poss their,localizations
R80 T882 T879 nsubjpass localizations,determined
R81 T883 T882 amod chromosomal,localizations
R82 T884 T882 cc or,localizations
R83 T885 T886 amod physiological,functions
R84 T886 T882 conj functions,localizations
R85 T887 T879 aux have,determined
R86 T888 T879 neg not,determined
R87 T889 T879 auxpass been,determined
R88 T890 T879 punct .,determined
R89 T894 T895 det A,search
R90 T895 T897 nsubj search,failed
R91 T896 T895 compound Blast,search
R92 T898 T895 prep of,search
R93 T899 T900 nmod mouse,databases
R94 T900 T898 pobj databases,of
R95 T901 T900 amod genomic,databases
R96 T902 T903 aux to,locate
R97 T903 T897 xcomp locate,failed
R98 T904 T905 det the,gene
R99 T905 T903 dobj gene,locate
R100 T906 T905 compound ESG1,gene
R101 T907 T897 punct .,failed
R102 T909 T910 nsubj We,identified
R103 T911 T912 amod several,clones
R104 T912 T910 dobj clones,identified
R105 T913 T912 amod bacterial,clones
R106 T914 T912 amod artificial,clones
R107 T915 T912 acl containing,clones
R108 T916 T917 det the,gene
R109 T917 T915 dobj gene,containing
R110 T918 T917 compound mouse,gene
R111 T919 T917 compound ESG1,gene
R112 T920 T912 cc and,clones
R113 T921 T922 det an,sequence
R114 T922 T912 conj sequence,clones
R115 T923 T922 amod additional,sequence
R116 T924 T925 npadvmod ESG1,like
R117 T925 T922 amod like,sequence
R118 T926 T925 punct -,like
R119 T927 T922 prep with,sequence
R120 T928 T929 det a,structure
R121 T929 T927 pobj structure,with
R122 T930 T929 amod similar,structure
R123 T931 T929 compound gene,structure
R124 T932 T929 prep from,structure
R125 T933 T932 pobj chromosome,from
R126 T934 T933 nummod 9,chromosome
R127 T935 T910 punct .,identified
R128 T937 T938 det The,sequence
R129 T938 T942 nsubj sequence,contained
R130 T939 T940 npadvmod ESG1,like
R131 T940 T938 amod like,sequence
R132 T941 T940 punct -,like
R133 T943 T944 det a,mutations
R134 T944 T942 dobj mutations,contained
R135 T945 T944 amod multiple,mutations
R136 T946 T944 amod critical,mutations
R137 T947 T942 punct ", ",contained
R138 T948 T942 advcl indicating,contained
R139 T949 T950 mark that,was
R140 T950 T948 ccomp was,indicating
R141 T951 T950 nsubj it,was
R142 T952 T953 det a,pseudogene
R143 T953 T950 attr pseudogene,was
R144 T954 T953 amod duplicated,pseudogene
R145 T955 T942 punct .,contained
R146 T957 T958 det The,region
R147 T958 T962 nsubj region,exhibited
R148 T959 T958 nummod 5,region
R149 T960 T959 punct ',5
R150 T961 T958 compound flanking,region
R151 T963 T958 prep of,region
R152 T964 T965 det the,gene
R153 T965 T963 pobj gene,of
R154 T966 T965 compound ESG1,gene
R155 T967 T965 punct ", ",gene
R156 T968 T965 cc but,gene
R157 T969 T968 neg not,but
R158 T970 T965 conj that,gene
R159 T971 T970 prep of,that
R160 T972 T973 det the,pseudogene
R161 T973 T971 pobj pseudogene,of
R162 T974 T962 punct ", ",exhibited
R163 T975 T976 amod strong,activity
R164 T976 T962 dobj activity,exhibited
R165 T977 T976 nmod enhancer,activity
R166 T978 T977 cc and,enhancer
R167 T979 T977 conj promoter,enhancer
R168 T980 T962 prep in,exhibited
R169 T981 T982 amod undifferentiated,cells
R170 T982 T980 pobj cells,in
R171 T983 T982 compound ES,cells
R172 T984 T962 prep by,exhibited
R173 T985 T986 compound luciferase,reporter
R174 T986 T987 compound reporter,assay
R175 T987 T984 pobj assay,by
R176 T988 T962 punct .,exhibited
R177 T990 T991 aux To,study
R178 T991 T992 advcl study,replaced
R179 T993 T994 det the,functions
R180 T994 T991 dobj functions,study
R181 T995 T994 amod physiological,functions
R182 T996 T994 prep of,functions
R183 T997 T998 det the,gene
R184 T998 T996 pobj gene,of
R185 T999 T998 compound ESG1,gene
R186 T1000 T992 punct ", ",replaced
R187 T1001 T992 nsubj we,replaced
R188 T1002 T1003 det this,sequence
R189 T1003 T992 dobj sequence,replaced
R190 T1004 T1003 prep in,sequence
R191 T1005 T1006 compound ES,cells
R192 T1006 T1004 pobj cells,in
R193 T1007 T992 prep with,replaced
R194 T1008 T1009 det a,cassette
R195 T1009 T1007 pobj cassette,with
R196 T1010 T1011 compound β,geo
R197 T1011 T1009 compound geo,cassette
R198 T1012 T1011 punct -,geo
R199 T1013 T992 prep by,replaced
R200 T1014 T1015 amod homologous,recombination
R201 T1015 T1013 pobj recombination,by
R202 T1016 T992 punct .,replaced
R203 T1018 T1019 prep Despite,developed
R204 T1020 T1021 amod specific,expression
R205 T1021 T1018 pobj expression,Despite
R206 T1022 T1021 prep in,expression
R207 T1023 T1024 amod early,embryos
R208 T1024 T1022 pobj embryos,in
R209 T1025 T1024 cc and,embryos
R210 T1026 T1027 compound germ,cells
R211 T1027 T1024 conj cells,embryos
R212 T1028 T1019 punct ", ",developed
R213 T1029 T1030 nmod ESG1,mice
R214 T1030 T1019 nsubj mice,developed
R215 T1031 T1029 punct -,ESG1
R216 T1032 T1029 punct /,ESG1
R217 T1033 T1029 punct -,ESG1
R218 T1034 T1019 advmod normally,developed
R219 T1035 T1019 cc and,developed
R220 T1036 T1019 conj were,developed
R221 T1037 T1036 acomp fertile,were
R222 T1038 T1019 punct .,developed
R223 T1040 T1041 nsubj We,generated
R224 T1042 T1041 advmod also,generated
R225 T1043 T1044 nmod ESG1,cells
R226 T1044 T1041 dobj cells,generated
R227 T1045 T1043 punct -,ESG1
R228 T1046 T1043 punct /,ESG1
R229 T1047 T1043 punct -,ESG1
R230 T1048 T1044 compound ES,cells
R231 T1049 T1050 preconj both,by
R232 T1050 T1041 prep by,generated
R233 T1051 T1052 det a,recombination
R234 T1052 T1050 pobj recombination,by
R235 T1053 T1052 amod second,recombination
R236 T1054 T1052 amod independent,recombination
R237 T1055 T1052 amod homologous,recombination
R238 T1056 T1050 cc and,by
R239 T1057 T1058 advmod directly,from
R240 T1058 T1050 conj from,by
R241 T1059 T1058 pobj blastocysts,from
R242 T1060 T1059 acl derived,blastocysts
R243 T1061 T1060 prep from,derived
R244 T1062 T1063 amod heterozygous,intercrosses
R245 T1063 T1061 pobj intercrosses,from
R246 T1064 T1041 punct .,generated
R247 T1066 T1067 nmod Northern,blot
R248 T1067 T1068 nmod blot,analyses
R249 T1068 T1072 nsubj analyses,confirmed
R250 T1069 T1067 cc and,blot
R251 T1070 T1071 compound western,blot
R252 T1071 T1067 conj blot,blot
R253 T1073 T1074 det the,absence
R254 T1074 T1072 dobj absence,confirmed
R255 T1075 T1074 prep of,absence
R256 T1076 T1075 pobj ESG1,of
R257 T1077 T1074 prep in,absence
R258 T1078 T1079 det these,cells
R259 T1079 T1077 pobj cells,in
R260 T1080 T1072 punct .,confirmed
R261 T1082 T1083 det These,cells
R262 T1083 T1085 nsubj cells,demonstrated
R263 T1084 T1083 compound ES,cells
R264 T1086 T1087 amod normal,morphology
R265 T1087 T1085 dobj morphology,demonstrated
R266 T1088 T1087 punct ", ",morphology
R267 T1089 T1087 conj proliferation,morphology
R268 T1090 T1089 punct ", ",proliferation
R269 T1091 T1089 cc and,proliferation
R270 T1092 T1089 conj differentiation,proliferation
R271 T1093 T1085 punct .,demonstrated
R272 T1097 T1098 det The,gene
R273 T1098 T1101 nsubjpass gene,located
R274 T1099 T1098 compound mouse,gene
R275 T1100 T1098 compound ESG1,gene
R276 T1102 T1098 punct ", ",gene
R277 T1103 T1104 advmod together,with
R278 T1104 T1098 prep with,gene
R279 T1105 T1106 det a,pseudogene
R280 T1106 T1104 pobj pseudogene,with
R281 T1107 T1106 amod duplicated,pseudogene
R282 T1108 T1101 punct ", ",located
R283 T1109 T1101 auxpass is,located
R284 T1110 T1101 prep on,located
R285 T1111 T1110 pobj chromosome,on
R286 T1112 T1111 nummod 9,chromosome
R287 T1113 T1101 punct .,located
R288 T1115 T1116 prep Despite,is
R289 T1117 T1118 poss its,expression
R290 T1118 T1115 pobj expression,Despite
R291 T1119 T1118 amod specific,expression
R292 T1120 T1118 prep in,expression
R293 T1121 T1122 amod pluripotent,cells
R294 T1122 T1120 pobj cells,in
R295 T1123 T1122 cc and,cells
R296 T1124 T1125 compound germ,cells
R297 T1125 T1122 conj cells,cells
R298 T1126 T1116 punct ", ",is
R299 T1127 T1116 nsubj ESG1,is
R300 T1128 T1116 acomp dispensable,is
R301 T1129 T1128 prep for,dispensable
R302 T1130 T1131 compound self,renewal
R303 T1131 T1129 pobj renewal,for
R304 T1132 T1131 punct -,renewal
R305 T1133 T1131 prep of,renewal
R306 T1134 T1135 compound ES,cells
R307 T1135 T1133 pobj cells,of
R308 T1136 T1131 cc and,renewal
R309 T1137 T1131 conj establishment,renewal
R310 T1138 T1137 prep of,establishment
R311 T1139 T1138 pobj germcells,of
R312 T1140 T1116 punct .,is