PMC:1382200 / 93-853
Annnotations
craft-sa-dev
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T681 | 0-1 | NN | denotes | μ |
| T682 | 2-9 | NN | denotes | calpain |
| T683 | 1-2 | HYPH | denotes | - |
| T684 | 24-27 | VBP | denotes | are |
| T685 | 10-13 | CC | denotes | and |
| T686 | 14-15 | NN | denotes | m |
| T687 | 16-23 | NN | denotes | calpain |
| T688 | 15-16 | HYPH | denotes | - |
| T689 | 28-40 | RB | denotes | ubiquitously |
| T690 | 41-50 | VBN | denotes | expressed |
| T691 | 51-60 | NNS | denotes | proteases |
| T692 | 61-71 | VBN | denotes | implicated |
| T693 | 72-74 | IN | denotes | in |
| T694 | 75-83 | JJ | denotes | cellular |
| T695 | 84-93 | NN | denotes | migration |
| T696 | 93-95 | , | denotes | , |
| T697 | 95-99 | NN | denotes | cell |
| T698 | 100-105 | NN | denotes | cycle |
| T699 | 106-117 | NN | denotes | progression |
| T700 | 117-119 | , | denotes | , |
| T701 | 119-131 | JJ | denotes | degenerative |
| T702 | 132-141 | NNS | denotes | processes |
| T703 | 142-145 | CC | denotes | and |
| T704 | 146-150 | NN | denotes | cell |
| T705 | 151-156 | NN | denotes | death |
| T706 | 156-157 | . | denotes | . |
| T707 | 157-331 | sentence | denotes | These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (μ-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. |
| T708 | 158-163 | DT | denotes | These |
| T709 | 178-185 | NNS | denotes | enzymes |
| T710 | 164-177 | JJ | denotes | heterodimeric |
| T711 | 190-198 | VBN | denotes | composed |
| T712 | 186-189 | VBP | denotes | are |
| T713 | 199-201 | IN | denotes | of |
| T714 | 202-210 | JJ | denotes | distinct |
| T715 | 221-229 | NNS | denotes | subunits |
| T716 | 211-220 | JJ | denotes | catalytic |
| T717 | 229-231 | , | denotes | , |
| T718 | 231-238 | VBN | denotes | encoded |
| T719 | 239-241 | IN | denotes | by |
| T720 | 242-247 | NN | denotes | Capn1 |
| T721 | 248-249 | -LRB- | denotes | ( |
| T722 | 249-250 | NN | denotes | μ |
| T723 | 251-258 | NN | denotes | calpain |
| T724 | 250-251 | HYPH | denotes | - |
| T725 | 258-259 | -RRB- | denotes | ) |
| T726 | 260-262 | CC | denotes | or |
| T727 | 263-268 | NN | denotes | Capn2 |
| T728 | 269-270 | -LRB- | denotes | ( |
| T729 | 270-271 | NN | denotes | m |
| T730 | 272-279 | NN | denotes | calpain |
| T731 | 271-272 | HYPH | denotes | - |
| T732 | 279-280 | -RRB- | denotes | ) |
| T733 | 280-282 | , | denotes | , |
| T734 | 282-285 | CC | denotes | and |
| T735 | 286-287 | DT | denotes | a |
| T736 | 306-313 | NN | denotes | subunit |
| T737 | 288-294 | JJ | denotes | common |
| T738 | 295-305 | JJ | denotes | regulatory |
| T739 | 314-321 | VBN | denotes | encoded |
| T740 | 322-324 | IN | denotes | by |
| T741 | 325-330 | NN | denotes | Capn4 |
| T742 | 330-331 | . | denotes | . |
| T743 | 331-552 | sentence | denotes | Disruption of the mouse Capn4 gene abolished both μ-calpain and m-calpain activity, and resulted in embryonic lethality, thereby suggesting essential roles for one or both of these enzymes during mammalian embryogenesis. |
| T744 | 332-342 | NN | denotes | Disruption |
| T745 | 367-376 | VBD | denotes | abolished |
| T746 | 343-345 | IN | denotes | of |
| T747 | 346-349 | DT | denotes | the |
| T748 | 362-366 | NN | denotes | gene |
| T749 | 350-355 | NN | denotes | mouse |
| T750 | 356-361 | NN | denotes | Capn4 |
| T751 | 377-381 | CC | denotes | both |
| T752 | 384-391 | NN | denotes | calpain |
| T753 | 382-383 | NN | denotes | μ |
| T754 | 383-384 | HYPH | denotes | - |
| T755 | 406-414 | NN | denotes | activity |
| T756 | 392-395 | CC | denotes | and |
| T757 | 396-397 | NN | denotes | m |
| T758 | 398-405 | NN | denotes | calpain |
| T759 | 397-398 | HYPH | denotes | - |
| T760 | 414-416 | , | denotes | , |
| T761 | 416-419 | CC | denotes | and |
| T762 | 420-428 | VBD | denotes | resulted |
| T763 | 429-431 | IN | denotes | in |
| T764 | 432-441 | JJ | denotes | embryonic |
| T765 | 442-451 | NN | denotes | lethality |
| T766 | 451-453 | , | denotes | , |
| T767 | 453-460 | RB | denotes | thereby |
| T768 | 461-471 | VBG | denotes | suggesting |
| T769 | 472-481 | JJ | denotes | essential |
| T770 | 482-487 | NNS | denotes | roles |
| T771 | 488-491 | IN | denotes | for |
| T772 | 492-495 | CD | denotes | one |
| T773 | 496-498 | CC | denotes | or |
| T774 | 499-503 | DT | denotes | both |
| T775 | 504-506 | IN | denotes | of |
| T776 | 507-512 | DT | denotes | these |
| T777 | 513-520 | NNS | denotes | enzymes |
| T778 | 521-527 | IN | denotes | during |
| T779 | 528-537 | JJ | denotes | mammalian |
| T780 | 538-551 | NN | denotes | embryogenesis |
| T781 | 551-552 | . | denotes | . |
| T782 | 552-760 | sentence | denotes | Disruption of the Capn1 gene produced viable, fertile mice implying that either m-calpain could compensate for the loss of μ-calpain, or that the loss of m-calpain was responsible for death of Capn4-/- mice. |
| T783 | 553-563 | NN | denotes | Disruption |
| T784 | 582-590 | VBD | denotes | produced |
| T785 | 564-566 | IN | denotes | of |
| T786 | 567-570 | DT | denotes | the |
| T787 | 577-581 | NN | denotes | gene |
| T788 | 571-576 | NN | denotes | Capn1 |
| T789 | 591-597 | JJ | denotes | viable |
| T790 | 607-611 | NNS | denotes | mice |
| T791 | 597-599 | , | denotes | , |
| T792 | 599-606 | JJ | denotes | fertile |
| T793 | 612-620 | VBG | denotes | implying |
| T794 | 621-625 | IN | denotes | that |
| T795 | 649-659 | VB | denotes | compensate |
| T796 | 626-632 | DT | denotes | either |
| T797 | 633-634 | NN | denotes | m |
| T798 | 635-642 | NN | denotes | calpain |
| T799 | 634-635 | HYPH | denotes | - |
| T800 | 643-648 | MD | denotes | could |
| T801 | 660-663 | IN | denotes | for |
| T802 | 664-667 | DT | denotes | the |
| T803 | 668-672 | NN | denotes | loss |
| T804 | 673-675 | IN | denotes | of |
| T805 | 676-677 | NN | denotes | μ |
| T806 | 678-685 | NN | denotes | calpain |
| T807 | 677-678 | HYPH | denotes | - |
| T808 | 685-687 | , | denotes | , |
| T809 | 687-689 | CC | denotes | or |
| T810 | 690-694 | IN | denotes | that |
| T811 | 717-720 | VBD | denotes | was |
| T812 | 695-698 | DT | denotes | the |
| T813 | 699-703 | NN | denotes | loss |
| T814 | 704-706 | IN | denotes | of |
| T815 | 707-708 | NN | denotes | m |
| T816 | 709-716 | NN | denotes | calpain |
| T817 | 708-709 | HYPH | denotes | - |
| T818 | 721-732 | JJ | denotes | responsible |
| T819 | 733-736 | IN | denotes | for |
| T820 | 737-742 | NN | denotes | death |
| T821 | 743-745 | IN | denotes | of |
| T822 | 746-751 | NN | denotes | Capn4 |
| T823 | 755-759 | NNS | denotes | mice |
| T824 | 751-752 | SYM | denotes | - |
| T825 | 752-753 | HYPH | denotes | / |
| T826 | 753-754 | SYM | denotes | - |
| T827 | 759-760 | . | denotes | . |
| R73 | T747 | T748 | det | the,gene |
| R74 | T748 | T746 | pobj | gene,of |
| R12 | T681 | T682 | compound | μ,calpain |
| R14 | T683 | T682 | punct | -,calpain |
| R15 | T685 | T682 | cc | and,calpain |
| R16 | T686 | T687 | compound | m,calpain |
| R18 | T688 | T687 | punct | -,calpain |
| R19 | T689 | T690 | advmod | ubiquitously,expressed |
| R20 | T690 | T691 | amod | expressed,proteases |
| R21 | T691 | T684 | attr | proteases,are |
| R22 | T692 | T691 | acl | implicated,proteases |
| R23 | T693 | T692 | prep | in,implicated |
| R24 | T694 | T695 | amod | cellular,migration |
| R25 | T695 | T693 | pobj | migration,in |
| R26 | T696 | T695 | punct | ", ",migration |
| R27 | T697 | T698 | compound | cell,cycle |
| R28 | T698 | T699 | compound | cycle,progression |
| R29 | T699 | T695 | conj | progression,migration |
| R30 | T700 | T699 | punct | ", ",progression |
| R31 | T701 | T702 | amod | degenerative,processes |
| R32 | T702 | T699 | conj | processes,progression |
| R33 | T703 | T702 | cc | and,processes |
| R34 | T704 | T705 | compound | cell,death |
| R35 | T705 | T702 | conj | death,processes |
| R36 | T706 | T684 | punct | .,are |
| R37 | T708 | T709 | det | These,enzymes |
| R39 | T710 | T709 | amod | heterodimeric,enzymes |
| R40 | T712 | T711 | auxpass | are,composed |
| R41 | T713 | T711 | prep | of,composed |
| R42 | T714 | T715 | amod | distinct,subunits |
| R44 | T716 | T715 | amod | catalytic,subunits |
| R45 | T717 | T715 | punct | ", ",subunits |
| R46 | T718 | T715 | acl | encoded,subunits |
| R47 | T719 | T718 | agent | by,encoded |
| R48 | T720 | T719 | pobj | Capn1,by |
| R49 | T721 | T720 | punct | (,Capn1 |
| R50 | T722 | T723 | compound | μ,calpain |
| R52 | T724 | T723 | punct | -,calpain |
| R53 | T725 | T720 | punct | ),Capn1 |
| R54 | T726 | T720 | cc | or,Capn1 |
| R55 | T727 | T720 | conj | Capn2,Capn1 |
| R56 | T728 | T727 | punct | (,Capn2 |
| R57 | T729 | T730 | compound | m,calpain |
| R59 | T731 | T730 | punct | -,calpain |
| R60 | T732 | T715 | punct | ),subunits |
| R61 | T733 | T715 | punct | ", ",subunits |
| R62 | T734 | T715 | cc | and,subunits |
| R63 | T735 | T736 | det | a,subunit |
| R64 | T736 | T715 | conj | subunit,subunits |
| R65 | T737 | T736 | amod | common,subunit |
| R66 | T738 | T736 | amod | regulatory,subunit |
| R67 | T739 | T736 | acl | encoded,subunit |
| R68 | T740 | T739 | agent | by,encoded |
| R69 | T741 | T740 | pobj | Capn4,by |
| R70 | T742 | T711 | punct | .,composed |
| R71 | T744 | T745 | nsubj | Disruption,abolished |
| R72 | T746 | T744 | prep | of,Disruption |
| R75 | T749 | T748 | compound | mouse,gene |
| R76 | T750 | T748 | compound | Capn4,gene |
| R77 | T751 | T752 | preconj | both,calpain |
| R78 | T752 | T755 | nmod | calpain,activity |
| R79 | T753 | T752 | nmod | μ,calpain |
| R80 | T754 | T752 | punct | -,calpain |
| R81 | T755 | T745 | dobj | activity,abolished |
| R82 | T756 | T752 | cc | and,calpain |
| R83 | T757 | T758 | compound | m,calpain |
| R84 | T758 | T752 | conj | calpain,calpain |
| R85 | T759 | T758 | punct | -,calpain |
| R86 | T760 | T745 | punct | ", ",abolished |
| R87 | T761 | T745 | cc | and,abolished |
| R88 | T762 | T745 | conj | resulted,abolished |
| R89 | T763 | T762 | prep | in,resulted |
| R90 | T764 | T765 | amod | embryonic,lethality |
| R91 | T765 | T763 | pobj | lethality,in |
| R92 | T766 | T762 | punct | ", ",resulted |
| R93 | T767 | T768 | advmod | thereby,suggesting |
| R94 | T768 | T762 | advcl | suggesting,resulted |
| R95 | T769 | T770 | amod | essential,roles |
| R96 | T770 | T768 | dobj | roles,suggesting |
| R97 | T771 | T770 | prep | for,roles |
| R98 | T772 | T771 | pobj | one,for |
| R99 | T773 | T772 | cc | or,one |
| R100 | T774 | T772 | conj | both,one |
| R101 | T775 | T772 | prep | of,one |
| R102 | T776 | T777 | det | these,enzymes |
| R103 | T777 | T775 | pobj | enzymes,of |
| R104 | T778 | T770 | prep | during,roles |
| R105 | T779 | T780 | amod | mammalian,embryogenesis |
| R106 | T780 | T778 | pobj | embryogenesis,during |
| R107 | T781 | T745 | punct | .,abolished |
| R108 | T783 | T784 | nsubj | Disruption,produced |
| R109 | T785 | T783 | prep | of,Disruption |
| R110 | T786 | T787 | det | the,gene |
| R112 | T788 | T787 | compound | Capn1,gene |
| R113 | T789 | T790 | amod | viable,mice |
| R114 | T790 | T784 | dobj | mice,produced |
| R115 | T791 | T790 | punct | ", ",mice |
| R116 | T792 | T790 | amod | fertile,mice |
| R117 | T793 | T784 | advcl | implying,produced |
| R118 | T794 | T795 | mark | that,compensate |
| R119 | T795 | T793 | advcl | compensate,implying |
| R120 | T796 | T795 | mark | either,compensate |
| R121 | T797 | T798 | compound | m,calpain |
| R122 | T798 | T795 | nsubj | calpain,compensate |
| R123 | T799 | T798 | punct | -,calpain |
| R124 | T800 | T795 | aux | could,compensate |
| R125 | T801 | T795 | prep | for,compensate |
| R126 | T802 | T803 | det | the,loss |
| R127 | T803 | T801 | pobj | loss,for |
| R128 | T804 | T803 | prep | of,loss |
| R129 | T805 | T806 | compound | μ,calpain |
| R131 | T807 | T806 | punct | -,calpain |
| R132 | T808 | T795 | punct | ", ",compensate |
| R133 | T809 | T795 | cc | or,compensate |
| R134 | T810 | T811 | mark | that,was |
| R135 | T811 | T795 | conj | was,compensate |
| R136 | T812 | T813 | det | the,loss |
| R137 | T813 | T811 | nsubj | loss,was |
| R138 | T814 | T813 | prep | of,loss |
| R139 | T815 | T816 | compound | m,calpain |
| R140 | T816 | T814 | pobj | calpain,of |
| R141 | T817 | T816 | punct | -,calpain |
| R142 | T818 | T811 | acomp | responsible,was |
| R143 | T819 | T818 | prep | for,responsible |
| R144 | T820 | T819 | pobj | death,for |
| R145 | T821 | T820 | prep | of,death |
| R146 | T822 | T823 | nmod | Capn4,mice |
| R147 | T823 | T821 | pobj | mice,of |
| R148 | T824 | T822 | punct | -,Capn4 |
| R149 | T825 | T822 | punct | /,Capn4 |
| R150 | T826 | T822 | punct | -,Capn4 |
| R151 | T827 | T784 | punct | .,produced |
| R13 | T682 | T684 | nsubj | calpain,are |
| R17 | T687 | T682 | conj | calpain,calpain |
| R38 | T709 | T711 | nsubjpass | enzymes,composed |
| R43 | T715 | T713 | pobj | subunits,of |
| R51 | T723 | T720 | appos | calpain,Capn1 |
| R58 | T730 | T727 | appos | calpain,Capn2 |
| R111 | T787 | T785 | pobj | gene,of |
| R130 | T806 | T804 | pobj | calpain,of |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T537 | 41-50 | GO:0010467 | denotes | expressed |
| T538 | 75-93 | GO:0016477 | denotes | cellular migration |
| T539 | 95-105 | GO:0007049 | denotes | cell cycle |
| T540 | 146-156 | GO:0008219 | denotes | cell death |
| T541 | 242-247 | PR:000005009 | denotes | Capn1 |
| T542 | 263-268 | PR:000005015 | denotes | Capn2 |
| T543 | 295-305 | GO:0065007 | denotes | regulatory |
| T544 | 325-330 | PR:000005022 | denotes | Capn4 |
| T545 | 350-355 | NCBITaxon:10088 | denotes | mouse |
| T546 | 356-361 | PR:000005022 | denotes | Capn4 |
| T547 | 362-366 | SO:0000704 | denotes | gene |
| T548 | 432-441 | UBERON:0000922 | denotes | embryonic |
| T549 | 528-537 | NCBITaxon:40674 | denotes | mammalian |
| T550 | 538-551 | GO:0009790 | denotes | embryogenesis |
| T551 | 571-576 | PR:000005009 | denotes | Capn1 |
| T552 | 577-581 | SO:0000704 | denotes | gene |
| T553 | 607-611 | NCBITaxon:10088 | denotes | mice |
| T554 | 737-742 | GO:0016265 | denotes | death |
| T555 | 746-751 | PR:000005022 | denotes | Capn4 |
| T556 | 755-759 | NCBITaxon:10088 | denotes | mice |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T587 | 0-9 | GO_PR_EXT:calpain_1_complex | denotes | μ-calpain |
| T588 | 14-23 | GO_PR_EXT:calpain_2_complex | denotes | m-calpain |
| T589 | 41-50 | GO:0010467 | denotes | expressed |
| T590 | 51-60 | GO_EXT:0008233 | denotes | proteases |
| T591 | 75-83 | CL_GO_EXT:cell | denotes | cellular |
| T592 | 75-93 | GO:0016477 | denotes | cellular migration |
| T593 | 95-99 | CL_GO_EXT:cell | denotes | cell |
| T594 | 95-105 | GO:0007049 | denotes | cell cycle |
| T595 | 146-150 | CL_GO_EXT:cell | denotes | cell |
| T596 | 146-156 | GO:0008219 | denotes | cell death |
| T597 | 170-177 | GO_EXT:dimer_macromolecular_complex | denotes | dimeric |
| T598 | 178-185 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymes |
| T599 | 211-220 | GO_MOP_EXT:catalysis | denotes | catalytic |
| T600 | 231-238 | SO_EXT:sequence_coding_function | denotes | encoded |
| T601 | 242-247 | PR_EXT:000005009 | denotes | Capn1 |
| T602 | 249-258 | GO_PR_EXT:calpain_1_complex | denotes | μ-calpain |
| T603 | 263-268 | PR_EXT:000005015 | denotes | Capn2 |
| T604 | 270-279 | GO_PR_EXT:calpain_2_complex | denotes | m-calpain |
| T605 | 295-305 | GO:0065007 | denotes | regulatory |
| T606 | 314-321 | SO_EXT:sequence_coding_function | denotes | encoded |
| T607 | 325-330 | PR_EXT:000005022 | denotes | Capn4 |
| T608 | 350-355 | NCBITaxon:10088 | denotes | mouse |
| T609 | 356-361 | PR_EXT:000005022 | denotes | Capn4 |
| T610 | 362-366 | SO_EXT:0000704 | denotes | gene |
| T611 | 382-391 | GO_PR_EXT:calpain_1_complex | denotes | μ-calpain |
| T612 | 396-405 | GO_PR_EXT:calpain_2_complex | denotes | m-calpain |
| T613 | 432-441 | UBERON:0000922 | denotes | embryonic |
| T614 | 442-451 | GO_EXT:fatality_or_lethality | denotes | lethality |
| T615 | 513-520 | CHEBI_GO_SO_EXT:enzyme | denotes | enzymes |
| T616 | 528-537 | NCBITaxon:40674 | denotes | mammalian |
| T617 | 538-551 | GO:0009790 | denotes | embryogenesis |
| T618 | 571-576 | PR_EXT:000005009 | denotes | Capn1 |
| T619 | 577-581 | SO_EXT:0000704 | denotes | gene |
| T620 | 607-611 | NCBITaxon:10088 | denotes | mice |
| T621 | 633-642 | GO_PR_EXT:calpain_2_complex | denotes | m-calpain |
| T622 | 676-685 | GO_PR_EXT:calpain_1_complex | denotes | μ-calpain |
| T623 | 707-716 | GO_PR_EXT:calpain_2_complex | denotes | m-calpain |
| T624 | 737-742 | GO:0016265 | denotes | death |
| T625 | 746-751 | PR_EXT:000005022 | denotes | Capn4 |
| T626 | 751-752 | SO_EXT:sequence_nullness_or_absence | denotes | - |
| T627 | 753-754 | SO_EXT:sequence_nullness_or_absence | denotes | - |
| T628 | 755-759 | NCBITaxon:10088 | denotes | mice |