PMC:1382200 / 1281-1696 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T896","span":{"begin":5,"end":7},"obj":"IN"},{"id":"T897","span":{"begin":8,"end":11},"obj":"DT"},{"id":"T898","span":{"begin":12,"end":18},"obj":"NN"},{"id":"T899","span":{"begin":19,"end":22},"obj":"CC"},{"id":"T900","span":{"begin":23,"end":26},"obj":"RB"},{"id":"T901","span":{"begin":27,"end":29},"obj":"IN"},{"id":"T902","span":{"begin":30,"end":33},"obj":"DT"},{"id":"T903","span":{"begin":34,"end":44},"obj":"NNS"},{"id":"T904","span":{"begin":45,"end":50},"obj":"NN"},{"id":"T905","span":{"begin":50,"end":51},"obj":"."},{"id":"T906","span":{"begin":51,"end":63},"obj":"sentence"},{"id":"T907","span":{"begin":53,"end":63},"obj":"NN"},{"id":"T908","span":{"begin":63,"end":209},"obj":"sentence"},{"id":"T909","span":{"begin":64,"end":66},"obj":"PRP"},{"id":"T910","span":{"begin":67,"end":75},"obj":"VBP"},{"id":"T911","span":{"begin":76,"end":80},"obj":"IN"},{"id":"T912","span":{"begin":121,"end":128},"obj":"VBZ"},{"id":"T913","span":{"begin":81,"end":91},"obj":"JJ"},{"id":"T914","span":{"begin":92,"end":102},"obj":"NN"},{"id":"T915","span":{"begin":103,"end":105},"obj":"IN"},{"id":"T916","span":{"begin":106,"end":109},"obj":"DT"},{"id":"T917","span":{"begin":116,"end":120},"obj":"NN"},{"id":"T918","span":{"begin":110,"end":115},"obj":"NN"},{"id":"T919","span":{"begin":129,"end":131},"obj":"IN"},{"id":"T920","span":{"begin":132,"end":148},"obj":"JJ"},{"id":"T921","span":{"begin":159,"end":168},"obj":"NN"},{"id":"T922","span":{"begin":149,"end":158},"obj":"JJ"},{"id":"T923","span":{"begin":169,"end":176},"obj":"IN"},{"id":"T924","span":{"begin":177,"end":180},"obj":"DT"},{"id":"T925","span":{"begin":203,"end":208},"obj":"NN"},{"id":"T926","span":{"begin":181,"end":187},"obj":"NN"},{"id":"T927","span":{"begin":188,"end":191},"obj":"CC"},{"id":"T928","span":{"begin":192,"end":202},"obj":"NN"},{"id":"T929","span":{"begin":208,"end":209},"obj":"."},{"id":"T930","span":{"begin":209,"end":362},"obj":"sentence"},{"id":"T931","span":{"begin":210,"end":214},"obj":"DT"},{"id":"T932","span":{"begin":215,"end":226},"obj":"VBZ"},{"id":"T933","span":{"begin":227,"end":231},"obj":"IN"},{"id":"T934","span":{"begin":256,"end":260},"obj":"VBP"},{"id":"T935","span":{"begin":232,"end":233},"obj":"NN"},{"id":"T936","span":{"begin":234,"end":241},"obj":"NN"},{"id":"T937","span":{"begin":233,"end":234},"obj":"HYPH"},{"id":"T938","span":{"begin":242,"end":245},"obj":"CC"},{"id":"T939","span":{"begin":246,"end":247},"obj":"NN"},{"id":"T940","span":{"begin":248,"end":255},"obj":"NN"},{"id":"T941","span":{"begin":247,"end":248},"obj":"HYPH"},{"id":"T942","span":{"begin":261,"end":269},"obj":"JJ"},{"id":"T943","span":{"begin":270,"end":279},"obj":"NNS"},{"id":"T944","span":{"begin":279,"end":281},"obj":","},{"id":"T945","span":{"begin":281,"end":284},"obj":"CC"},{"id":"T946","span":{"begin":285,"end":289},"obj":"IN"},{"id":"T947","span":{"begin":300,"end":302},"obj":"VBZ"},{"id":"T948","span":{"begin":290,"end":291},"obj":"NN"},{"id":"T949","span":{"begin":292,"end":299},"obj":"NN"},{"id":"T950","span":{"begin":291,"end":292},"obj":"HYPH"},{"id":"T951","span":{"begin":303,"end":308},"obj":"JJ"},{"id":"T952","span":{"begin":309,"end":312},"obj":"IN"},{"id":"T953","span":{"begin":313,"end":324},"obj":"NN"},{"id":"T954","span":{"begin":325,"end":327},"obj":"IN"},{"id":"T955","span":{"begin":328,"end":331},"obj":"DT"},{"id":"T956","span":{"begin":355,"end":361},"obj":"NN"},{"id":"T957","span":{"begin":332,"end":347},"obj":"NN"},{"id":"T958","span":{"begin":348,"end":354},"obj":"JJ"},{"id":"T959","span":{"begin":361,"end":362},"obj":"."},{"id":"T3244","span":{"begin":375,"end":378},"obj":"DT"},{"id":"T3246","span":{"begin":379,"end":382},"obj":"CD"},{"id":"T3247","span":{"begin":383,"end":393},"obj":"JJ"},{"id":"T3248","span":{"begin":394,"end":397},"obj":"NN"},{"id":"T3249","span":{"begin":399,"end":408},"obj":"JJ"},{"id":"T3250","span":{"begin":397,"end":398},"obj":"SYM"},{"id":"T3251","span":{"begin":398,"end":399},"obj":"HYPH"},{"id":"T3252","span":{"begin":408,"end":410},"obj":","}],"relations":[{"id":"R213","pred":"det","subj":"T897","obj":"T898"},{"id":"R214","pred":"pobj","subj":"T898","obj":"T896"},{"id":"R217","pred":"prep","subj":"T901","obj":"T900"},{"id":"R218","pred":"det","subj":"T902","obj":"T903"},{"id":"R219","pred":"pobj","subj":"T903","obj":"T901"},{"id":"R220","pred":"dobj","subj":"T904","obj":"T900"},{"id":"R222","pred":"nsubj","subj":"T909","obj":"T910"},{"id":"R223","pred":"mark","subj":"T911","obj":"T912"},{"id":"R224","pred":"ccomp","subj":"T912","obj":"T910"},{"id":"R225","pred":"amod","subj":"T913","obj":"T914"},{"id":"R226","pred":"nsubj","subj":"T914","obj":"T912"},{"id":"R227","pred":"prep","subj":"T915","obj":"T914"},{"id":"R228","pred":"det","subj":"T916","obj":"T917"},{"id":"R229","pred":"pobj","subj":"T917","obj":"T915"},{"id":"R230","pred":"compound","subj":"T918","obj":"T917"},{"id":"R231","pred":"prep","subj":"T919","obj":"T912"},{"id":"R232","pred":"amod","subj":"T920","obj":"T921"},{"id":"R234","pred":"amod","subj":"T922","obj":"T921"},{"id":"R235","pred":"prep","subj":"T923","obj":"T912"},{"id":"R236","pred":"det","subj":"T924","obj":"T925"},{"id":"R237","pred":"pobj","subj":"T925","obj":"T923"},{"id":"R238","pred":"nmod","subj":"T926","obj":"T925"},{"id":"R239","pred":"cc","subj":"T927","obj":"T926"},{"id":"R240","pred":"conj","subj":"T928","obj":"T926"},{"id":"R241","pred":"punct","subj":"T929","obj":"T910"},{"id":"R242","pred":"nsubj","subj":"T931","obj":"T932"},{"id":"R243","pred":"mark","subj":"T933","obj":"T934"},{"id":"R244","pred":"advcl","subj":"T934","obj":"T932"},{"id":"R245","pred":"compound","subj":"T935","obj":"T936"},{"id":"R246","pred":"nsubj","subj":"T936","obj":"T934"},{"id":"R247","pred":"punct","subj":"T937","obj":"T936"},{"id":"R248","pred":"cc","subj":"T938","obj":"T936"},{"id":"R249","pred":"compound","subj":"T939","obj":"T940"},{"id":"R250","pred":"conj","subj":"T940","obj":"T936"},{"id":"R251","pred":"punct","subj":"T941","obj":"T940"},{"id":"R252","pred":"amod","subj":"T942","obj":"T943"},{"id":"R253","pred":"dobj","subj":"T943","obj":"T934"},{"id":"R254","pred":"punct","subj":"T944","obj":"T934"},{"id":"R255","pred":"cc","subj":"T945","obj":"T934"},{"id":"R256","pred":"mark","subj":"T946","obj":"T947"},{"id":"R257","pred":"conj","subj":"T947","obj":"T934"},{"id":"R258","pred":"compound","subj":"T948","obj":"T949"},{"id":"R259","pred":"nsubj","subj":"T949","obj":"T947"},{"id":"R260","pred":"punct","subj":"T950","obj":"T949"},{"id":"R261","pred":"acomp","subj":"T951","obj":"T947"},{"id":"R262","pred":"prep","subj":"T952","obj":"T951"},{"id":"R263","pred":"pobj","subj":"T953","obj":"T952"},{"id":"R264","pred":"prep","subj":"T954","obj":"T953"},{"id":"R265","pred":"det","subj":"T955","obj":"T956"},{"id":"R266","pred":"pobj","subj":"T956","obj":"T954"},{"id":"R267","pred":"nmod","subj":"T957","obj":"T956"},{"id":"R268","pred":"amod","subj":"T958","obj":"T956"},{"id":"R269","pred":"punct","subj":"T959","obj":"T932"},{"id":"R296","pred":"npadvmod","subj":"T3248","obj":"T3249"},{"id":"R299","pred":"punct","subj":"T3250","obj":"T3248"},{"id":"R300","pred":"punct","subj":"T3251","obj":"T3249"},{"id":"R233","pred":"pobj","subj":"T921","obj":"T919"}],"text":"cted at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.\n\nBackground\nThe two ubiquitous Ca2+-dependent, cyste"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T569","span":{"begin":12,"end":18},"obj":"UBERON:0000085"},{"id":"T570","span":{"begin":34,"end":44},"obj":"UBERON:0000358"},{"id":"T571","span":{"begin":110,"end":115},"obj":"PR:000005015"},{"id":"T572","span":{"begin":116,"end":120},"obj":"SO:0000704"},{"id":"T573","span":{"begin":136,"end":148},"obj":"GO:0007566"},{"id":"T574","span":{"begin":149,"end":158},"obj":"UBERON:0000922"},{"id":"T575","span":{"begin":181,"end":187},"obj":"UBERON:0000085"},{"id":"T576","span":{"begin":192,"end":202},"obj":"UBERON:0000358"},{"id":"T577","span":{"begin":313,"end":327},"obj":"_FRAGMENT"},{"id":"T578","span":{"begin":355,"end":361},"obj":"GO:0009790"},{"id":"T579","span":{"begin":335,"end":347},"obj":"GO:0007566"},{"id":"T580","span":{"begin":348,"end":354},"obj":"NCBITaxon:39107"},{"id":"T581","span":{"begin":355,"end":361},"obj":"UBERON:0000922"},{"id":"T2931","span":{"begin":394,"end":398},"obj":"CHEBI:29108"}],"relations":[{"id":"R1","pred":"_lexicallyChainedTo","subj":"T578","obj":"T577"}],"text":"cted at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.\n\nBackground\nThe two ubiquitous Ca2+-dependent, cyste"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T648","span":{"begin":12,"end":18},"obj":"UBERON:0000085"},{"id":"T649","span":{"begin":34,"end":44},"obj":"UBERON:0000358"},{"id":"T650","span":{"begin":110,"end":115},"obj":"PR_EXT:000005015"},{"id":"T651","span":{"begin":116,"end":120},"obj":"SO_EXT:0000704"},{"id":"T652","span":{"begin":136,"end":148},"obj":"GO:0007566"},{"id":"T653","span":{"begin":149,"end":158},"obj":"UBERON:0000922"},{"id":"T654","span":{"begin":159,"end":168},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T655","span":{"begin":181,"end":187},"obj":"UBERON:0000085"},{"id":"T656","span":{"begin":192,"end":202},"obj":"UBERON:0000358"},{"id":"T657","span":{"begin":232,"end":241},"obj":"GO_PR_EXT:calpain_1_complex"},{"id":"T658","span":{"begin":246,"end":255},"obj":"GO_PR_EXT:calpain_2_complex"},{"id":"T659","span":{"begin":290,"end":299},"obj":"GO_PR_EXT:calpain_2_complex"},{"id":"T660","span":{"begin":313,"end":327},"obj":"_FRAGMENT"},{"id":"T661","span":{"begin":355,"end":361},"obj":"GO:0009790"},{"id":"T662","span":{"begin":335,"end":347},"obj":"GO:0007566"},{"id":"T663","span":{"begin":348,"end":354},"obj":"NCBITaxon:39107"},{"id":"T664","span":{"begin":355,"end":361},"obj":"UBERON:0000922"},{"id":"T3037","span":{"begin":394,"end":398},"obj":"CHEBI:29108"}],"relations":[{"id":"R2","pred":"_lexicallyChainedTo","subj":"T661","obj":"T660"}],"text":"cted at the morula but not at the blastocyts stage.\n\nConclusion\nWe conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.\n\nBackground\nThe two ubiquitous Ca2+-dependent, cyste"}