cted at the morula but not at the blastocyts stage.

Conclusion
We conclude that homozygous disruption of the Capn2 gene results in pre-implantation embryonic lethality between the morula and blastocyst stage. This establishes that μ-calpain and m-calpain have distinct functions, and that m-calpain is vital for development of the preimplantation murine embryo.

Background
The two ubiquitous Ca2+-dependent, cyste