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mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T1410","span":{"begin":724,"end":733},"obj":"Anaphor"},{"id":"T1409","span":{"begin":48,"end":55},"obj":"Antecedent"},{"id":"T1408","span":{"begin":35,"end":42},"obj":"Antecedent"},{"id":"T1407","span":{"begin":30,"end":33},"obj":"Antecedent"},{"id":"T1406","span":{"begin":26,"end":28},"obj":"Antecedent"},{"id":"T1405","span":{"begin":218,"end":229},"obj":"Anaphor"},{"id":"T1412","span":{"begin":735,"end":742},"obj":"Antecedent"},{"id":"T1411","span":{"begin":747,"end":752},"obj":"Antecedent"}],"relations":[{"id":"R746","pred":"boundBy","subj":"T1405","obj":"T1406"},{"id":"R747","pred":"boundBy","subj":"T1405","obj":"T1407"},{"id":"R748","pred":"boundBy","subj":"T1405","obj":"T1408"},{"id":"R749","pred":"boundBy","subj":"T1405","obj":"T1409"},{"id":"R750","pred":"boundBy","subj":"T1410","obj":"T1411"},{"id":"R751","pred":"boundBy","subj":"T1410","obj":"T1412"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T1447","span":{"begin":1098,"end":1106},"obj":"Protein"},{"id":"T1446","span":{"begin":1080,"end":1088},"obj":"Protein"},{"id":"T1445","span":{"begin":1025,"end":1026},"obj":"Protein"},{"id":"T1444","span":{"begin":938,"end":939},"obj":"Protein"},{"id":"T1443","span":{"begin":868,"end":876},"obj":"Protein"},{"id":"T1442","span":{"begin":764,"end":766},"obj":"Protein"},{"id":"T1441","span":{"begin":747,"end":752},"obj":"Protein"},{"id":"T1440","span":{"begin":735,"end":742},"obj":"Protein"},{"id":"T1439","span":{"begin":588,"end":600},"obj":"Protein"},{"id":"T1438","span":{"begin":581,"end":583},"obj":"Protein"},{"id":"T1437","span":{"begin":386,"end":388},"obj":"Protein"},{"id":"T1436","span":{"begin":48,"end":55},"obj":"Protein"},{"id":"T1435","span":{"begin":35,"end":42},"obj":"Protein"},{"id":"T1434","span":{"begin":30,"end":33},"obj":"Protein"},{"id":"T1433","span":{"begin":26,"end":28},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"GO-BP","denotations":[{"id":"T1288","span":{"begin":1000,"end":1024},"obj":"http://purl.obolibrary.org/obo/GO_0060319"},{"id":"T1286","span":{"begin":911,"end":936},"obj":"http://purl.obolibrary.org/obo/GO_0060318"},{"id":"T1285","span":{"begin":767,"end":783},"obj":"http://purl.obolibrary.org/obo/GO_0016458"},{"id":"T1282","span":{"begin":1010,"end":1024},"obj":"http://purl.obolibrary.org/obo/GO_0030218"},{"id":"T1281","span":{"begin":922,"end":936},"obj":"http://purl.obolibrary.org/obo/GO_0030218"},{"id":"T1280","span":{"begin":636,"end":650},"obj":"http://purl.obolibrary.org/obo/GO_0030218"},{"id":"T1279","span":{"begin":489,"end":503},"obj":"http://purl.obolibrary.org/obo/GO_0030218"},{"id":"T1278","span":{"begin":438,"end":461},"obj":"http://purl.obolibrary.org/obo/GO_0009888"},{"id":"T1277","span":{"begin":329,"end":343},"obj":"http://purl.obolibrary.org/obo/GO_0002524"},{"id":"T1269","span":{"begin":1100,"end":1106},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1268","span":{"begin":1082,"end":1088},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1267","span":{"begin":870,"end":876},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1266","span":{"begin":406,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1265","span":{"begin":12,"end":18},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1256","span":{"begin":450,"end":461},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T1254","span":{"begin":204,"end":229},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"GO-MF","denotations":[{"id":"T1471","span":{"begin":12,"end":18},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1475","span":{"begin":1100,"end":1106},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1474","span":{"begin":1082,"end":1088},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1473","span":{"begin":870,"end":876},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T1472","span":{"begin":406,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005344"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"GO-CC","denotations":[{"id":"T1496","span":{"begin":532,"end":536},"obj":"http://purl.obolibrary.org/obo/GO_0060417"},{"id":"T1495","span":{"begin":74,"end":84},"obj":"http://purl.obolibrary.org/obo/GO_0005694"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"sentences","denotations":[{"id":"T1221","span":{"begin":908,"end":1075},"obj":"Sentence"},{"id":"T1222","span":{"begin":1076,"end":1172},"obj":"Sentence"},{"id":"T1220","span":{"begin":815,"end":907},"obj":"Sentence"},{"id":"T1219","span":{"begin":760,"end":814},"obj":"Sentence"},{"id":"T1218","span":{"begin":607,"end":759},"obj":"Sentence"},{"id":"T1217","span":{"begin":480,"end":606},"obj":"Sentence"},{"id":"T1216","span":{"begin":400,"end":479},"obj":"Sentence"},{"id":"T1215","span":{"begin":193,"end":399},"obj":"Sentence"},{"id":"T1214","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"T34","span":{"begin":0,"end":192},"obj":"Sentence"},{"id":"T35","span":{"begin":193,"end":399},"obj":"Sentence"},{"id":"T36","span":{"begin":400,"end":479},"obj":"Sentence"},{"id":"T37","span":{"begin":480,"end":606},"obj":"Sentence"},{"id":"T38","span":{"begin":607,"end":759},"obj":"Sentence"},{"id":"T39","span":{"begin":760,"end":814},"obj":"Sentence"},{"id":"T40","span":{"begin":815,"end":907},"obj":"Sentence"},{"id":"T41","span":{"begin":908,"end":1075},"obj":"Sentence"},{"id":"T42","span":{"begin":1076,"end":1172},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"simple1","denotations":[{"id":"T1674","span":{"begin":1098,"end":1106},"obj":"Protein"},{"id":"T1673","span":{"begin":1080,"end":1088},"obj":"Protein"},{"id":"T1672","span":{"begin":1025,"end":1026},"obj":"Protein"},{"id":"T1671","span":{"begin":938,"end":939},"obj":"Protein"},{"id":"T1670","span":{"begin":868,"end":876},"obj":"Protein"},{"id":"T1669","span":{"begin":764,"end":766},"obj":"Protein"},{"id":"T1668","span":{"begin":747,"end":752},"obj":"Protein"},{"id":"T1667","span":{"begin":735,"end":742},"obj":"Protein"},{"id":"T1666","span":{"begin":588,"end":600},"obj":"Protein"},{"id":"T1665","span":{"begin":581,"end":583},"obj":"Protein"},{"id":"T1664","span":{"begin":386,"end":388},"obj":"Protein"},{"id":"T1663","span":{"begin":48,"end":55},"obj":"Protein"},{"id":"T1662","span":{"begin":35,"end":42},"obj":"Protein"},{"id":"T1661","span":{"begin":30,"end":33},"obj":"Protein"},{"id":"T1660","span":{"begin":26,"end":28},"obj":"Protein"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T4286","span":{"begin":1117,"end":1127},"obj":"Regulation"},{"id":"T4285","span":{"begin":943,"end":952},"obj":"Positive_regulation"},{"id":"T4284","span":{"begin":1046,"end":1055},"obj":"Regulation"},{"id":"T4283","span":{"begin":832,"end":841},"obj":"Negative_regulation"},{"id":"T4282","span":{"begin":775,"end":783},"obj":"Negative_regulation"},{"id":"T4281","span":{"begin":710,"end":717},"obj":"Gene_expression"},{"id":"T4280","span":{"begin":573,"end":580},"obj":"Gene_expression"},{"id":"T4252","span":{"begin":1098,"end":1106},"obj":"Protein"},{"id":"T4251","span":{"begin":1080,"end":1088},"obj":"Protein"},{"id":"T4250","span":{"begin":1025,"end":1026},"obj":"Protein"},{"id":"T4249","span":{"begin":938,"end":939},"obj":"Protein"},{"id":"T4248","span":{"begin":868,"end":876},"obj":"Protein"},{"id":"T4247","span":{"begin":764,"end":766},"obj":"Protein"},{"id":"T4246","span":{"begin":747,"end":752},"obj":"Protein"},{"id":"T4245","span":{"begin":735,"end":742},"obj":"Protein"},{"id":"T4244","span":{"begin":588,"end":600},"obj":"Protein"},{"id":"T4243","span":{"begin":581,"end":583},"obj":"Protein"},{"id":"T4242","span":{"begin":386,"end":388},"obj":"Protein"},{"id":"T4241","span":{"begin":48,"end":55},"obj":"Protein"},{"id":"T4240","span":{"begin":35,"end":42},"obj":"Protein"},{"id":"T4239","span":{"begin":30,"end":33},"obj":"Protein"},{"id":"T4238","span":{"begin":26,"end":28},"obj":"Protein"}],"relations":[{"id":"R3034","pred":"themeOf","subj":"T4243","obj":"T4280"},{"id":"R3035","pred":"themeOf","subj":"T4244","obj":"T4280"},{"id":"R3036","pred":"themeOf","subj":"T4245","obj":"T4281"},{"id":"R3037","pred":"themeOf","subj":"T4246","obj":"T4281"},{"id":"R3038","pred":"themeOf","subj":"T4247","obj":"T4282"},{"id":"R3039","pred":"themeOf","subj":"T4248","obj":"T4283"},{"id":"R3040","pred":"themeOf","subj":"T4249","obj":"T4285"},{"id":"R3041","pred":"themeOf","subj":"T4250","obj":"T4284"},{"id":"R3042","pred":"themeOf","subj":"T4251","obj":"T4286"}],"text":"The mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

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mouse β-globin genes {ɛy, βh1, β-major, and β-minor} are clustered on Chromosome 7 and they are highly homologous to their human counterparts in organizational structure and function [22]. High-level expression of these genes requires a regulatory element, the locus control region that is characterized by a set of nuclease hypersensitive sites spread over 25 kb located 5′ of the ɛy gene [23]. The β-globin genes are expressed in a tissue- and development-specific fashion. In mice, erythropoiesis originates in the embryonic yolk sac where primitive erythroid cells express ɛy and βh-1 globins [22]. At 11.5 d post coitus (dpc), erythropoiesis shifts to the fetal liver where definitive erythroid cells express adult β globins (β major and minor) [22]. The ɛy gene is silenced in definitive erythroid cells. The mechanism of silencing of its human counterpart, ɛ globin, has been studied extensively. In definitive erythropoiesis, ɛ is activated and silenced autonomously [24,25], although in primitive erythropoiesis ɛ also appears to be regulated competitively [26]. The γ-globin to adult β-globin switch is controlled by promoter competition for the LCR [24,25]."}

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