PMC:1359074 / 35286-35886 JSONTXT

{"project":"2_test","denotations":[{"id":"16462943-14530442-85761024","span":{"begin":15,"end":17},"obj":"14530442"},{"id":"16462943-12677004-85761025","span":{"begin":192,"end":194},"obj":"12677004"},{"id":"T89386","span":{"begin":15,"end":17},"obj":"14530442"},{"id":"T39276","span":{"begin":192,"end":194},"obj":"12677004"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

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[15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T16053","span":{"begin":252,"end":254},"obj":"Protein"},{"id":"T16052","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T16051","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T16050","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T16049","span":{"begin":0,"end":4},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T16450","span":{"begin":216,"end":220},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T16449","span":{"begin":107,"end":111},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T16448","span":{"begin":76,"end":80},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T16447","span":{"begin":43,"end":47},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T16446","span":{"begin":0,"end":4},"obj":"http://www.uniprot.org/uniprot/P35712"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"GO-MF","denotations":[{"id":"T16056","span":{"begin":231,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"sentences","denotations":[{"id":"T16008","span":{"begin":282,"end":600},"obj":"Sentence"},{"id":"T16007","span":{"begin":197,"end":281},"obj":"Sentence"},{"id":"T16006","span":{"begin":49,"end":196},"obj":"Sentence"},{"id":"T16005","span":{"begin":0,"end":48},"obj":"Sentence"},{"id":"T261","span":{"begin":0,"end":48},"obj":"Sentence"},{"id":"T262","span":{"begin":49,"end":196},"obj":"Sentence"},{"id":"T263","span":{"begin":197,"end":281},"obj":"Sentence"},{"id":"T264","span":{"begin":282,"end":600},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"simple1","denotations":[{"id":"T16072","span":{"begin":252,"end":254},"obj":"Protein"},{"id":"T16071","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T16070","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T16069","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T16068","span":{"begin":0,"end":4},"obj":"Protein"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

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[15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T16520","span":{"begin":321,"end":364},"obj":"Protein"},{"id":"T16519","span":{"begin":216,"end":220},"obj":"Protein"},{"id":"T16518","span":{"begin":212,"end":215},"obj":"Protein"},{"id":"T16517","span":{"begin":132,"end":137},"obj":"Negative_regulation"},{"id":"T16516","span":{"begin":142,"end":152},"obj":"Protein"},{"id":"T16515","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T16514","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T16513","span":{"begin":31,"end":42},"obj":"Positive_regulation"},{"id":"T16512","span":{"begin":31,"end":42},"obj":"Positive_regulation"},{"id":"T16511","span":{"begin":31,"end":42},"obj":"Gene_expression"},{"id":"T16510","span":{"begin":31,"end":42},"obj":"Gene_expression"},{"id":"T16509","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T16508","span":{"begin":0,"end":4},"obj":"Protein"}],"relations":[{"id":"R11464","pred":"themeOf","subj":"T16508","obj":"T16510"},{"id":"R11465","pred":"themeOf","subj":"T16509","obj":"T16511"},{"id":"R11466","pred":"themeOf","subj":"T16510","obj":"T16512"},{"id":"R11467","pred":"themeOf","subj":"T16511","obj":"T16513"},{"id":"R11468","pred":"themeOf","subj":"T16516","obj":"T16517"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"testone","denotations":[{"id":"T15957","span":{"begin":252,"end":254},"obj":"Protein"},{"id":"T15956","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T15955","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T15954","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T15953","span":{"begin":0,"end":4},"obj":"Protein"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}

{"project":"test3","denotations":[{"id":"T15994","span":{"begin":252,"end":254},"obj":"Protein"},{"id":"T15993","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T15992","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T15991","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T15990","span":{"begin":0,"end":4},"obj":"Protein"},{"id":"T15976","span":{"begin":252,"end":254},"obj":"Protein"},{"id":"T15975","span":{"begin":107,"end":111},"obj":"Protein"},{"id":"T15974","span":{"begin":76,"end":80},"obj":"Protein"},{"id":"T15973","span":{"begin":43,"end":47},"obj":"Protein"},{"id":"T15972","span":{"begin":0,"end":4},"obj":"Protein"}],"text":"Sox6-pcDNA3.1 [15] was used to overexpress Sox6. A truncated version of the Sox6 overexpression construct (Sox6-ΔHMG-pcDNA3.1) that lacks the HMG domain was generated, as described by others [32]. Mutagenesis of Sox/Sox6 consensus binding sites of the ɛy promoter were done by PCR. Forward primers used to generate these mutagenized ɛy promoter reporter constructs include: MHB1661, 5′CCGCTCGAGAATGCAGTGCCAAGGGTCAGAACATTGTCTGCGAAG3′ (−63 to −19); MHB1662, 5′CCGCTCGAGAATGCAGAACAAAGGGTCAGATGAGTGTCTGCGAAGAA3′ (−63 to −16); and MHB1663, 5′CCGCTCGAGAATGCATGCCAAGGGTCAGATGAGTGTCTGCGAAGAA 3′ (−63 to −18)."}