PMC:1359074 / 32506-33630 JSONTXT

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in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. 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{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T11546","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T11545","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T11544","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T11543","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T11542","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T11553","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T11552","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T11551","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T11550","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T11549","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T11548","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T11547","span":{"begin":531,"end":535},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T13284","span":{"begin":936,"end":940},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13283","span":{"begin":864,"end":868},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13282","span":{"begin":729,"end":733},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13281","span":{"begin":531,"end":535},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13280","span":{"begin":426,"end":430},"obj":"http://www.uniprot.org/uniprot/P35712"},{"id":"T13279","span":{"begin":312,"end":316},"obj":"http://www.uniprot.org/uniprot/P35712"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"GO-BP","denotations":[{"id":"T11252","span":{"begin":248,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0016458"},{"id":"T11228","span":{"begin":995,"end":1001},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11227","span":{"begin":800,"end":806},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11226","span":{"begin":569,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11225","span":{"begin":241,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11224","span":{"begin":77,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11203","span":{"begin":1002,"end":1012},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"GO-MF","denotations":[{"id":"T11575","span":{"begin":241,"end":247},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11574","span":{"begin":77,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11588","span":{"begin":734,"end":741},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T11578","span":{"begin":995,"end":1001},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11577","span":{"begin":800,"end":806},"obj":"http://purl.obolibrary.org/obo/GO_0005344"},{"id":"T11576","span":{"begin":569,"end":575},"obj":"http://purl.obolibrary.org/obo/GO_0005344"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"GO-CC","denotations":[{"id":"T11599","span":{"begin":1093,"end":1097},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T11598","span":{"begin":142,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"sentences","denotations":[{"id":"T11200","span":{"begin":839,"end":1124},"obj":"Sentence"},{"id":"T11199","span":{"begin":749,"end":838},"obj":"Sentence"},{"id":"T11198","span":{"begin":587,"end":748},"obj":"Sentence"},{"id":"T11197","span":{"begin":411,"end":586},"obj":"Sentence"},{"id":"T11196","span":{"begin":264,"end":410},"obj":"Sentence"},{"id":"T11195","span":{"begin":0,"end":263},"obj":"Sentence"},{"id":"T244","span":{"begin":0,"end":263},"obj":"Sentence"},{"id":"T245","span":{"begin":264,"end":410},"obj":"Sentence"},{"id":"T246","span":{"begin":411,"end":586},"obj":"Sentence"},{"id":"T247","span":{"begin":587,"end":748},"obj":"Sentence"},{"id":"T248","span":{"begin":749,"end":838},"obj":"Sentence"},{"id":"T249","span":{"begin":839,"end":1124},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"simple1","denotations":[{"id":"T11817","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T11816","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T11815","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T11814","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T11813","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T11812","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T11811","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T11810","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T11809","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T11808","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T11807","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T11806","span":{"begin":75,"end":83},"obj":"Protein"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T15832","span":{"begin":1002,"end":1012},"obj":"Regulation"},{"id":"T15831","span":{"begin":576,"end":585},"obj":"Negative_regulation"},{"id":"T15830","span":{"begin":324,"end":329},"obj":"Binding"},{"id":"T15829","span":{"begin":253,"end":262},"obj":"Negative_regulation"},{"id":"T15828","span":{"begin":53,"end":65},"obj":"Positive_regulation"},{"id":"T15788","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T15787","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T15786","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T15785","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T15784","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T15783","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T15782","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T15781","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T15780","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T15779","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T15778","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T15777","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R11035","pred":"themeOf","subj":"T15777","obj":"T15828"},{"id":"R11036","pred":"themeOf","subj":"T15778","obj":"T15829"},{"id":"R11038","pred":"themeOf","subj":"T15779","obj":"T15830"},{"id":"R11040","pred":"themeOf","subj":"T15780","obj":"T15830"},{"id":"R11042","pred":"themeOf","subj":"T15783","obj":"T15831"},{"id":"R11045","pred":"themeOf","subj":"T15788","obj":"T15832"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T13420","span":{"begin":1002,"end":1012},"obj":"Regulation"},{"id":"T13419","span":{"begin":576,"end":585},"obj":"Negative_regulation"},{"id":"T13418","span":{"begin":324,"end":329},"obj":"Binding"},{"id":"T13417","span":{"begin":53,"end":65},"obj":"Positive_regulation"},{"id":"T13416","span":{"begin":253,"end":262},"obj":"Negative_regulation"},{"id":"T13378","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T13377","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T13376","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T13375","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T13374","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T13373","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T13372","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T13371","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T13370","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T13369","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T13368","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T13367","span":{"begin":75,"end":83},"obj":"Protein"}],"relations":[{"id":"R9210","pred":"themeOf","subj":"T13367","obj":"T13417"},{"id":"R9211","pred":"themeOf","subj":"T13368","obj":"T13416"},{"id":"R9213","pred":"themeOf","subj":"T13369","obj":"T13418"},{"id":"R9214","pred":"themeOf","subj":"T13370","obj":"T13418"},{"id":"R9215","pred":"themeOf","subj":"T13373","obj":"T13419"},{"id":"R9216","pred":"themeOf","subj":"T13378","obj":"T13420"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

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in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T13531","span":{"begin":1002,"end":1012},"obj":"Regulation"},{"id":"T13530","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T13529","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T13528","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T13527","span":{"begin":792,"end":811},"obj":"Protein"},{"id":"T13526","span":{"begin":729,"end":733},"obj":"Protein"},{"id":"T13525","span":{"begin":548,"end":557},"obj":"Positive_regulation"},{"id":"T13524","span":{"begin":576,"end":585},"obj":"Negative_regulation"},{"id":"T13523","span":{"begin":561,"end":575},"obj":"Protein"},{"id":"T13522","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T13521","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T13520","span":{"begin":324,"end":329},"obj":"Binding"},{"id":"T13519","span":{"begin":349,"end":357},"obj":"Entity"},{"id":"T13518","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T13517","span":{"begin":253,"end":262},"obj":"Negative_regulation"},{"id":"T13516","span":{"begin":53,"end":65},"obj":"Positive_regulation"},{"id":"T13515","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T13514","span":{"begin":69,"end":83},"obj":"Protein"}],"relations":[{"id":"R9270","pred":"themeOf","subj":"T13514","obj":"T13516"},{"id":"R9272","pred":"themeOf","subj":"T13515","obj":"T13517"},{"id":"R9274","pred":"themeOf","subj":"T13518","obj":"T13520"},{"id":"R9275","pred":"Site","subj":"T13519","obj":"T13520"},{"id":"R9277","pred":"causeOf","subj":"T13522","obj":"T13525"},{"id":"R9279","pred":"themeOf","subj":"T13523","obj":"T13524"},{"id":"R9280","pred":"themeOf","subj":"T13524","obj":"T13525"},{"id":"R9282","pred":"themeOf","subj":"T13530","obj":"T13531"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"testone","denotations":[{"id":"T10922","span":{"begin":576,"end":585},"obj":"Negative_regulation"},{"id":"T10921","span":{"begin":349,"end":357},"obj":"Entity"},{"id":"T10920","span":{"begin":340,"end":348},"obj":"Entity"},{"id":"T10866","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T10865","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T10864","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T10863","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T10862","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T10861","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T10860","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T10859","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T10919","span":{"begin":324,"end":329},"obj":"Binding"},{"id":"T10918","span":{"begin":253,"end":262},"obj":"Negative_regulation"},{"id":"T10917","span":{"begin":53,"end":65},"obj":"Negative_regulation"},{"id":"T10870","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T10869","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T10868","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T10867","span":{"begin":798,"end":806},"obj":"Protein"}],"relations":[{"id":"R7477","pred":"themeOf","subj":"T10859","obj":"T10917"},{"id":"R7478","pred":"themeOf","subj":"T10860","obj":"T10918"},{"id":"R7479","pred":"themeOf","subj":"T10861","obj":"T10919"},{"id":"R7480","pred":"themeOf","subj":"T10865","obj":"T10922"},{"id":"R7491","pred":"themeOf","subj":"T10921","obj":"T10919"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}

{"project":"test3","denotations":[{"id":"T11135","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T11134","span":{"begin":324,"end":329},"obj":"Binding"},{"id":"T11133","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T11132","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T11131","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T11015","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T11014","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T11013","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T11012","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T11011","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T11010","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T11009","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T11008","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T11007","span":{"begin":337,"end":339},"obj":"Protein"},{"id":"T11006","span":{"begin":312,"end":316},"obj":"Protein"},{"id":"T11005","span":{"begin":239,"end":247},"obj":"Protein"},{"id":"T11004","span":{"begin":75,"end":83},"obj":"Protein"},{"id":"T11144","span":{"begin":993,"end":1001},"obj":"Protein"},{"id":"T11143","span":{"begin":936,"end":940},"obj":"Protein"},{"id":"T11142","span":{"begin":864,"end":868},"obj":"Protein"},{"id":"T11141","span":{"begin":798,"end":806},"obj":"Protein"},{"id":"T11140","span":{"begin":654,"end":655},"obj":"Protein"},{"id":"T11139","span":{"begin":567,"end":575},"obj":"Protein"},{"id":"T11138","span":{"begin":531,"end":535},"obj":"Protein"},{"id":"T11137","span":{"begin":426,"end":430},"obj":"Protein"},{"id":"T11136","span":{"begin":349,"end":357},"obj":"Entity"}],"relations":[{"id":"R7537","pred":"themeOf","subj":"T11133","obj":"T11134"},{"id":"R7538","pred":"themeOf","subj":"T11136","obj":"T11134"}],"text":"Recently, in vivo and in vitro analyses suggest that reactivation of human ɛ-globin would be therapeutically beneficial to adults with sickle cell disease [47], providing a rationale for detailed investigations into the molecular basis of ɛ-globin gene silencing. The present study identifies a novel repressor, Sox6, which binds to the ɛy proximal promoter, potentially as part of a larger repression complex. Because murine Sox6 and its human counterpart are 94% identical at the amino acid level [48], it is possible that human Sox6 may also be important in human ɛ globin silencing. There is significant sequence homology between the human and mouse ɛ promoter regions, and the human promoter contains at least two potential Sox6 binding sites. Indeed, the existence of a silencer of the human ɛ globin gene has been proposed [49,50]. Thus, elucidation of the Sox6 repression mechanism and identification of other components of the Sox6-containing complex may further our understanding of ɛ globin regulation and potentially reveal additional molecular targets for the treatment of sickle cell anemia and β thalassemias."}