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In order to see if there exist any hotspots for these eQTLs, we tested eQTLs with p \u003c 0.001 for enrichment along the genome in overlapping 2-cM bins against the distribution of all liver eQTLs (Figure 4A) using a Fisher exact test. Figure 5D shows the significance of enrichment reported as −log10 of the enrichment p-value across the genome. One locus on Chromosome 19 was significantly enriched for eQTLs of transcripts correlated with the gonadal fat mass trait. As anticipated, there was an overlap of a correlated eQTL hotspot and a fat mass cQTL, specifically Chromosome 19 at 40 cM. This suggests that the genetic regulation of fat mass for the Chromosome 19 locus is more closely tied to liver gene expression than are the other four fat mass cQTLs."}