PMC:1310620 / 23636-48967 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1310620","sourcedb":"PMC","sourceid":"1310620","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1310620","text":"Acknowledgements\nThese studies and manuscript preparation were supported by grants from the National Cancer Institute (NCI), including CA85147 and CA 95806, and the George Isaac Cancer Research Fund. StaRT-PCR reagents for measurement of some of the genes were provided at no cost by Gene Express, Inc. Neither the NCI nor Gene Express, Inc. had any role in study design, collection, analysis, or interpretation of data, writing of the manuscript, or in the decision to submit the manuscript for publication.\n\nFigures and Tables\nFigure 1 Correlation of each transcription factor with XRCC1, ERCC5, GSTP1, SOD1, or GPX1. (a-f) Each panel presents the correlation coefficients (r values) for one transcription factor in relation to each of the five genes: (a) CEBPB, (b) CEBPG, (c) E2F1, (d) E2F3, (e) E2F6, (f) EVI1. The p value for each significant correlation is provided above the bar. For CEBPG, presented in panel b, the difference in r value between non-BC individuals and BC individuals was significant or nearly significant for each correlated gene, and the p value for each comparison is provided below the corresponding pair of bars.\nFigure 2 Scatter plot representation of bivariate correlation of CEBPG with XRCC1. (a, b) CEBPG/XRCC1 data from Figure 1b presented as scatter plots: (a) non-BC individuals, (b) BC individuals.\nTable 1 Demographic data of patients from whom the NBEC samples were obtained.\nSubject # Group Age Gender Histology Smoking Hx 1 Ethnicity\n63 NBCI2 77 M 75 W3\n64 NBCI 47 F 45 W\n136 NBCI 38 M 25 A.A.4\n139 NBCI 44 F 17.5 W\n150 NBCI 70 F 45 W\n156 NBCI 46 F NS5 A.A.\n157 NBCI 60 M \u003e100 W\n194 NBCI 57 M 3 W\n210 NBCI 40 M 34 W\n257 NBCI 69 F 20 W\n261 NBCI 73 F NS W\n282 NBCI 83 F 60 W\n285 NBCI 69 F NS W\n296 NBCI 43 F 20 W\n305 NBCI 50 F 40 W\n315 NBCI 64 M N/A6 W\n330 NBCI 39 M NS W\n331 NBCI N/A N/A N/A N/A\n334 NBCI 51 M \u003e50 W\n336 NBCI 31 F NS W\n337 NBCI 32 M 22 N/A\n339 NBCI 59 M 50 W\n361 NBCI 73 F NS H7\n363 NBCI 50 M 20 A.A.\n34 BCI8 80 M NSCLC9 40 W\n71 BCI 63 M NSCLC 100 W\n85 BCI 73 F SQ10 \u003e100 W\n88 BCI 85 M SQ 75 W\n99 BCI 63 M NSCLC 45 W\n118 BCI 72 M SQ 30 W\n146 BCI 64 F SCLC11 45 W\n147 BCI 76 M SCLC 75 W\n158 BCI 88 M SCLC 115.5 W\n167 BCI 60 F NSCLC 50 W\n171 BCI 67 M SCLC 100 W\n191 BCI 75 M SQ 54 W\n211 BCI 71 M SQ 50 W\n212 BCI 65 M SQ 67.5 W\n247 BCI 75 F SQ 50 W\n255 BCI 60 F NSCLC 30 W\n259 BCI 68 M CS12 137.5 W\n271 BCI 58 M AC13 94.5 W\n287 BCI 65 F NSCLC 50 W\n300 BCI 56 M SQ 34 W\n306 BCI 46 M SQ 30 W\n314 BCI 69 F BC14 NS W\n329 BCI 76 F PD15 \u003e37.5 W\n335 BCI 75 M SCLC 58 A.A.\nB3 BCI 63 M SQ 60 W\n1Pack years; 2Non-bronchogenic carcinoma individual; 3White; 4African-American; 5Non-smoker; 6Not available; 7Hispanic; 8Bronchogenic carcinoma individual; 9Non-small cell lung cancer; 10Squamous carcinoma; 11Small cell lung cancer; 12Carcinoma-in-situ; 13Adenocarcinoma;14Bronchogenic Cancer, histology not specified; 15Poorly differentiated carcinoma.\nTable 2 Sequence for each primer used for StaRT-PCR virtually-multiplexed transcript abundance measurement or for internal standard preparation (CT) [15].\nGene Accession # Primer Sequence Position Product\nACTB X00351 Forward 5' ATC CTC ACC CTG AAG TAC CC 3' 231\nReverse 5' CCA TCT CTT GCT CGA AGT CC 3' 704 493 bp\nCT 5' CCA TCT CTT GCT CGA AGT CCG CCA GCC AGG TCC AGA CGC A 3' 568 377 bp\nCAT X04076 Forward 5' CCA GAA GAA AGC GGT CAA GA 3' 1492\nReverse 5' AAC CTT CAT TTT CCC CTG GG 3' 1822 350 bp\nCT 5' AAC CTT CAT TTT CCC CTG GGC CAG TGA TGA GCG GGT TAC A 3' 1699 247 bp\nCEBPB NM_005194 Forward 5' TGT CCA AAC CAA CCG CAC AT 3' 1412\nReverse 5' AGC AAC AAG CCC GTA GGA AC 3' 1657 265 bp\nCT 5' AGC AAC AAG CCC GTA GGA ACA CGC GTT CAG CCA TGT TTA A 3' 1571 199 bp\nCEBPG U20240 Forward 5' CGG TTG AAA AGC AAG CAG AAA GCA 3' 488\nReverse 5' GAT CCC AGA AAA TAG CCT CCA ATG 3' 814 350 bp\nCT 5' GAT CCC AGA AAA TAG CCT CCA ATG AAC ATT CAA GCC ACA AGC TC 3' 726 282 bp\nE2F1 M96577 Forward 5' TGA TAC CCC AAC TCC CTC TA 3' 2076\nReverse 5' AAA GCA GGA GGG AAC AGA GC 3' 2452 396 bp\nCT 5' AAA GCA GGA GGG AAC AGA GCA CTG CAG GGA CCA CAG G 3' 2363 327 bp\nE2F3 Y10479 Forward 5' TGA AAG CCC CTC CAG AAA CAA G 3' 1019\nReverse 5' GCA GCA GGG GAG GCA GTA AGT T 3' 1336 339 bp\nCT 5' GCA GCA GGG GAG GCA GTA AGT TGG GGA GGC CAG AGG AGA AAG GT 3' 1253 278 bp\nE2F6 AF059292 Forward 5' GGG CCT GCT GCC ATC AAA AAT A 3' 99\nReverse 5' CCG CTT TCG GAC TCC CAG TTT 3' 283 205 bp\nCT 5' CCG CTT TCG GAC TCC CAG TTA GCG ATA CAT CAA AAC GAG G 3' 184 125 bp\nERCC1 M13194 Forward 5' CTG GAG CCC CGA GGA AGC 3' 739\nReverse 5' CAC TGG GGG TTT CCT TTG 3' 1049 328 bp\nCT 5' CAC TGG GGG TTT CCT TGG AAG GCC AGA TCT TCT CTT 3 928 240 bp\nERCC2 X52221 Forward 5' GGC CTT CTT CAC CAG CTA C 3' 1608\nReverse 5' GTA GTC CGT CTT GCC CCT G 3' 2004 415 bp\nCT 5' GTA GTC CGT CTT GCC CCT GTG GAA CTG GTC CCG CAG GT 3' 2597 346 bp\nERCC4 U64315 Forward 5' AGT GCA TCT CCA TGT CCC GCT ACT A 3' 2213\nReverse 5' CGA TGT TCT TAA CGT GGT GCA TCA A 3' 2578 390 bp\nCT 5' CGA TGT TCT TAA CGT GGT GCA TCA ACA GGC TGT GGC TTG CTT TGT 3' 2433 265 bp\nERCC5 D16305 Forward 5' AAG GAA AGA GAA AGA AGC AGC AGC CA 3' 3087\nReverse 5' CAA ACA CAG ATC TGG CGG TCA CGA GG 3' 3501 440 bp\nCT 5' CAA ACA CAG ATC TGG CGG TCA CGA GGA GCT TCC TTC ACT GAG TTC TGC GAA T 3' 3401 366 bp\nEVI1 NM_005241 Forward 5' CGC CGG ATA TCC ACG AAG A 3' 302\nReverse 5' ATG CTG AGA GCG AAT GTG C 3' 711 428 bp\nCT 5' ATG CTG AGA GCG AAT GTG CTT AAA TGC CTT GGG ACA CT 3' 587 323 bp\nGPX1 Y00433 Forward 5' CCT GGT GGT GCT CGG CTT CC 3' 522\nReverse 5' CAA TGG TCT GGA AGC GGC GG 3' 852 350 bp\nCT 5' CAA TGG TCT GGA AGC GGC GGA CCG GAG ACC AGG TGA TGA G 3' 757 279 bp\nGPX3 D16360 Forward 5' GCA GAG CCG GGG ACA AGA GAA 3' 113\nReverse 5' CTG CTC TTT CTC TCC ATT GAC 3' 471 379 bp\nCT 5' CTG CTC TTT CTC TCC ATT GAC GCT CTT CCT GTA GTG CAT TCA 3' 298 227 bp\nGSTM1,2,4,5 J03817 Forward 5' GGG ACG CTC CTG ATT ATG AC 3' 122\nReverse 5' GCA AAC CAT GGC CGC TTC CC 3' 442 340 bp\nCT 5' GCA AAC CAT GGC CGC TTC CCT TCT CCA AAA TGT CCA CAC G 3' 301 219 bp\nGSTM3 J05459 Forward 5' GTG CGA GTC GTC TAT GGT TC 3' 23\nReverse 5' AGT TGT GTG CGG AAA TCC AT 3' 342 339 bp\nCT 5' AGT TGT GTG CGG AAA TCC ATT GCT CTG GGT GAT CTT GTT C 3' 230 247 bp\nGSTP1 X08058 Forward 5' TCC GCT GCA AAT ACA TCT CC 3' 305\nReverse 5' TGT TTC CCG TTG CCA TTG AT 3' 616 331 bp\nCT 5' TGT TTC CCG TTG CCA TTG ATT AGG ACC TCA TGG ATC AGC A 3' 485 220 bp\nGSTT1 X79389 Forward 5' GCT CTA CCT GGA CCT GCT GT 3' 12\nReverse 5' GGA ACA CAG GGA ACA TCA CC 3' 351 359 bp\nCT 5' GGA ACA CAG GGA ACA TCA CCT AGA GCA GGA TGG CCA CAC T 3' 199 227 bp\nGSTZ1 U86529 Forward 5' TCA CCC CCT ACC CTA CCA TCA GC 3' 806\nReverse 5' ATT TCA GCG CGG GCA TTC TTT 3' 1267 482 bp\nCT 5' ATT TCA GCG CGG GCA TTC TTT CCG CAT TCT CAT CTC AGC CTC AC 3' 1161 399 bp\nmGST1 J03746 Forward 5' GTC GGA GCA CGG ATC TAC CAC A 3' 404\nReverse 5' TTC CTC TGC TCC CCT CCT ACC TA 3' 623 242 bp\nCT 5' TTC CTC TGC TCC CCT CCT ACC TAT TTT CAG CAA CCT GTA AGC C 3' 505 144 bp\nSOD1 X02317 Forward 5' TGA AGG TGT GGG GAA GCA TTA 3' 153\nReverse 5' TTA CAC CAC AAG CCA AAC GAC 3' 492 360 bp\nCT 5' TTA CAC CAC AAG CCA AAC GAC TGA TGC AAT GGT CTC CTG AGA 3' 384 273 bp\nXPA D14533 Forward 5' CTC GGC GAC GGC GGC TGC GGC TAC TGG AG 3' 178\nReverse 5' TGT CGG ACT TCC TTT GCT TCT TCT AAT GC 3' 629 480 bp\nCT 5' TGT CGG ACT TCC TTT GCT TCT TCT AAT GCT CTT TTT TCT AAA TCA CAG TCT 3' 487 360 bp\nXRCC1 M36089 Forward 5' CCC CTG AAG AGA CCA AAG CA 3' 1906\nReverse 5' CCA TTG AAG GCT GTG ACG TA 3' 2241 355 bp\nCT 5' CCA TTG AAG GCT GTG ACG TAT CAG GGA CTG GCA GAT G 3' 2142 276 bp\nTable 3 Virtually-multiplexed transcript abundance data.\nSUBJECT # GROUP CEBPB CEBPG E2F1 E2F3 E2F6 EVI1 CAT ERCC1 ERCC2 ERCC4 ERCC5\n63 NBCI 7.2E+03 6.4E+02 2.7E+02 1.9E+02 3.4E+02 6.1E+01 2.0E+04 1.1E+05 3.8E+03 1.1E+02 4.3E+04\n64 NBCI 7.9E+03 1.7E+03 2.0E+03 2.0E+01 1.7E+02 2.5E+01 2.5E+04 3.0E+05 3.4E+03 8.1E+01 2.0E+05\n136 NBCI 6.2E+03 2.1E+02 7.0E+02 1.0E-02 5.0E+01 6.0E+01 2.9E+03 7.4E+03 5.9E+02 5.6E+01 1.9E+04\n139 NBCI 4.5E+03 3.4E+03 2.3E+04 5.6E+02 1.0E+03 1.0E+03 6.1E+05 1.2E+06 2.2E+04 3.9E+03 4.6E+05\n150 NBCI 8.5E+03 7.4E+02 1.6E+02 1.1E+02 4.1E+01 3.2E+02 3.5E+04 1.7E+05 5.7E+03 6.9E+02 7.2E+04\n156 NBCI 2.1E+04 1.2E+03 7.5E+02 ND1 ND 1.4E+02 1.5E+04 1.8E+05 2.0E+03 2.9E+02 3.0E+04\n157 NBCI 2.3E+04 4.1E+03 3.1E+03 2.1E+02 6.1E+02 1.4E+02 3.5E+05 5.6E+05 8.4E+03 1.6E+03 2.1E+05\n194 NBCI 6.5E+03 2.1E+03 2.9E+02 2.6E+02 8.5E+02 4.7E+02 4.5E+04 6.1E+05 4.7E+03 4.4E+02 8.9E+04\n210 NBCI 1.0E+04 2.1E+03 7.6E+02 4.0E+02 6.1E+02 3.6E+02 7.6E+04 7.6E+04 3.4E+03 7.7E+02 7.2E+04\n257 NBCI 1.1E+04 1.8E+03 2.7E+02 8.9E+02 1.7E+03 9.7E+02 1.0E+05 2.6E+05 1.6E+03 7.6E+02 7.4E+04\n261 NBCI 7.6E+03 1.3E+03 2.5E+02 1.7E+02 1.6E+02 9.4E+01 4.4E+04 2.7E+05 5.1E+03 4.6E+02 1.3E+05\n282 NBCI 6.4E+03 1.2E+03 5.4E+02 4.1E+01 2.9E+01 1.2E+02 4.1E+04 1.0E+05 6.0E+03 8.1E+02 4.0E+04\n285 NBCI 2.6E+03 4.4E+02 2.5E+03 1.1E+03 ND 1.2E+02 3.7E+04 9.1E+04 1.6E+03 7.7E+03 1.6E+04\n296 NBCI 1.9E+04 1.0E+03 1.0E+03 ND 2.8E+01 ND 6.9E+04 2.5E+05 3.6E+03 1.7E+02 7.1E+04\n305 NBCI 1.8E+03 9.1E+01 6.1E+02 ND 8.7E+01 2.6E+02 2.0E+04 4.9E+04 4.3E+02 2.8E+02 1.3E+04\n315 NBCI 3.5E+03 1.3E+03 1.2E+03 2.0E+02 7.5E+01 6.1E+02 4.7E+04 2.1E+05 2.7E+03 2.4E+03 6.2E+04\n330 NBCI 2.7E+03 2.4E+02 4.0E+02 1.1E+02 3.5E+02 4.0E+02 3.6E+04 8.3E+04 1.5E+03 1.7E+03 2.8E+04\n331 NBCI 7.3E+03 1.3E+03 8.0E+02 ND ND ND 8.6E+04 2.6E+05 6.5E+02 6.4E+02 6.2E+04\n334 NBCI 3.7E+03 6.1E+02 1.1E+03 2.3E+01 1.9E+01 4.0E+01 7.8E+04 1.4E+05 2.5E+03 1.3E+03 5.1E+04\n336 NBCI 3.6E+03 8.4E+02 2.8E+03 4.3E+02 1.2E+02 2.5E+02 8.9E+04 2.1E+05 7.9E+03 3.1E+03 9.5E+04\n337 NBCI 5.0E+03 9.3E+02 1.1E+03 1.6E+02 2.5E+02 ND 6.5E+04 1.9E+05 3.3E+03 1.3E+03 4.2E+04\n339 NBCI 2.5E+03 3.2E+02 5.2E+02 3.4E+01 4.3E+01 6.3E+01 5.0E+04 8.7E+04 2.3E+03 7.7E+02 3.2E+04\n361 NBCI 7.9E+03 2.5E+03 6.7E+02 5.8E+02 1.4E+03 3.5E+02 6.7E+04 2.5E+05 1.5E+03 2.8E+03 4.7E+04\n363 NBCI 6.2E+03 1.7E+03 1.4E+03 1.1E+02 1.9E+02 5.2E+01 7.6E+04 1.4E+05 3.7E+03 7.3E+02 7.2E+04\n34 BCI 1.9E+03 1.7E+03 5.7E+02 2.4E+02 1.2E+02 3.7E+02 6.7E+04 5.6E+05 6.1E+03 1.5E+03 1.2E+05\n71 BCI 7.6E+03 1.2E+03 1.3E+03 1.7E+01 1.8E+02 2.1E+01 9.5E+04 6.7E+05 1.8E+04 2.4E+02 2.2E+05\n85 BCI 1.0E+04 9.7E+02 8.7E+02 6.3E+01 ND ND 2.6E+04 4.9E+04 1.1E+03 3.9E+02 2.3E+04\n88 BCI 1.5E+03 4.0E+02 4.2E+02 1.1E+02 ND ND 3.1E+04 2.9E+04 2.7E+03 3.6E+02 3.9E+04\n99 BCI 1.4E+04 3.3E+03 2.6E+03 2.2E+02 3.1E+03 1.4E+02 2.1E+05 2.0E+05 3.7E+03 9.3E+02 1.4E+05\n118 BCI 1.5E+03 1.2E+03 2.8E+02 ND ND 1.4E+02 2.4E+04 3.5E+04 1.9E+03 1.2E+03 1.7E+04\n146 BCI 1.9E+04 1.2E+03 2.3E+02 1.2E+02 1.6E+03 6.0E+01 3.1E+04 1.4E+05 4.9E+03 2.7E+02 6.2E+04\n147 BCI 2.8E+03 1.3E+03 N/A2 3.6E+02 2.8E+02 3.8E+02 6.1E+04 3.0E+05 2.7E+03 1.1E+03 1.8E+04\n158 BCI 4.9E+03 8.8E+02 1.9E+02 2.8E+01 4.0E+02 6.8E+01 2.2E+04 1.4E+05 1.7E+03 1.5E+02 1.3E+04\n167 BCI 6.7E+03 9.2E+02 4.2E+02 1.8E+02 8.2E+02 3.8E+02 8.9E+04 1.1E+05 2.2E+03 2.8E+02 4.1E+04\n171 BCI 1.0E+04 3.9E+03 3.2E+03 5.1E+02 8.9E+01 2.4E+02 5.3E+05 8.3E+05 1.3E+04 6.3E+02 1.6E+05\n191 BCI 1.6E+04 2.4E+03 1.5E+02 1.5E+02 7.1E+01 1.2E+02 2.0E+04 9.6E+04 2.5E+03 3.4E+02 1.2E+04\n211 BCI 3.8E+03 1.1E+03 6.5E+02 6.3E+02 3.2E+02 2.9E+02 8.3E+04 3.5E+05 2.8E+03 3.2E+02 9.1E+04\n212 BCI 1.8E+04 2.8E+03 6.0E+02 3.4E+02 2.0E+02 2.2E+02 3.4E+04 2.1E+05 5.2E+03 3.0E+02 3.6E+04\n247 BCI 6.5E+03 7.5E+02 6.4E+02 1.8E+02 ND 1.2E+02 7.8E+04 4.4E+04 5.5E+02 2.7E+03 1.3E+04\n255 BCI 1.9E+04 1.1E+03 6.1E+02 1.8E+01 2.3E+02 7.6E+01 1.1E+05 6.5E+05 1.2E+04 1.2E+03 3.8E+05\n259 BCI 8.4E+03 6.4E+02 5.1E+02 ND 6.7E+01 4.0E+01 4.7E+04 1.5E+05 2.6E+03 3.8E+02 7.9E+04\n271 BCI 4.1E+03 6.6E+02 1.4E+03 6.5E+01 2.7E+02 1.9E+02 9.1E+04 1.5E+05 1.6E+03 ND 1.5E+05\n287 BCI 8.7E+03 1.1E+03 9.5E+01 7.4E+01 4.0E+01 2.6E+02 4.7E+04 1.2E+05 6.5E+03 1.1E+02 4.1E+04\n300 BCI 4.9E+03 4.4E+02 4.1E+02 4.4E+01 ND 5.1E+01 3.4E+04 6.9E+04 1.0E+03 1.0E+03 2.6E+04\n306 BCI 6.5E+03 6.8E+02 4.9E+02 4.4E+01 ND 1.7E+01 3.7E+04 2.5E+05 2.8E+03 3.2E+02 4.1E+04\n314 BCI 4.4E+03 9.3E+02 4.8E+02 3.1E+02 ND 1.9E+02 5.3E+04 6.2E+04 4.5E+03 5.2E+02 3.1E+04\n329 BCI 1.4E+04 3.5E+02 2.4E+02 ND ND ND 7.9E+04 1.5E+05 1.4E+03 ND 1.5E+05\n335 BCI 4.2E+03 3.7E+02 2.2E+03 3.3E+02 2.4E+02 2.4E+02 4.8E+04 1.9E+05 9.8E+03 3.1E+02 3.3E+04\nB3 BCI 7.4E+03 9.3E+02 1.4E+02 2.4E+02 1.8E+02 3.8E+02 3.4E+04 1.6E+05 2.2E+03 2.8E+02 4.1E+04\nSUBJECT # GROUP GPX1 GPX3 GSTM15 GSTM3 GSTP1 GSTT1 GSTZ1 MGST1 SOD1 XPA XRCC1\n63 NBCI 8.4E+05 1.5E+03 7.3E+03 3.9E+03 1.9E+06 ND 3.1E+03 1.7E+05 1.6E+05 2.5E+03 2.1E+04\n64 NBCI 4.4E+05 3.1E+02 1.5E+04 2.6E+03 3.5E+06 6.4E+03 2.0E+03 1.6E+05 6.5E+05 2.2E+03 4.2E+04\n136 NBCI 2.0E+05 5.2E+02 6.3E+03 2.2E+03 5.3E+05 ND 8.9E+02 3.2E+04 5.3E+04 1.1E+03 4.4E+03\n139 NBCI 1.8E+06 3.2E+03 5.2E+04 8.3E+03 3.2E+07 ND 2.8E+04 8.4E+05 2.2E+06 2.6E+04 1.6E+05\n150 NBCI 2.1E+05 2.8E+03 1.1E+04 1.1E+03 1.5E+06 ND 3.1E+03 3.1E+04 2.0E+05 2.0E+03 3.1E+04\n156 NBCI 4.8E+05 3.9E+03 1.9E+04 6.5E+03 2.9E+06 ND 4.9E+03 5.8E+04 1.3E+05 4.0E+03 2.5E+04\n157 NBCI 2.4E+06 2.0E+03 2.6E+04 3.3E+03 1.8E+07 8.5E+03 3.6E+03 3.6E+05 1.8E+06 6.2E+03 1.7E+05\n194 NBCI 5.4E+05 4.0E+03 1.2E+04 1.1E+03 7.8E+06 7.7E+03 3.2E+03 9.6E+04 5.8E+05 3.7E+03 2.4E+05\n210 NBCI 3.2E+05 3.3E+03 4.1E+03 2.6E+03 3.9E+06 1.8E+03 3.7E+03 7.2E+04 3.3E+05 4.8E+03 2.9E+04\n257 NBCI 6.3E+05 2.5E+03 1.1E+04 1.2E+02 2.8E+06 8.7E+03 2.9E+03 2.3E+04 1.2E+05 2.6E+03 4.9E+04\n261 NBCI 7.6E+05 4.7E+03 1.6E+04 7.4E+03 3.1E+06 1.5E+03 1.8E+03 1.2E+05 4.5E+05 4.9E+03 7.2E+04\n282 NBCI 4.6E+05 2.5E+03 1.3E+04 2.3E+03 1.9E+06 1.5E+04 1.3E+03 6.5E+04 4.5E+05 2.0E+03 3.1E+04\n285 NBCI 4.3E+05 5.3E+03 8.4E+04 6.2E+02 3.5E+06 7.3E+03 9.2E+03 3.0E+04 2.3E+05 ND 2.0E+04\n296 NBCI 8.1E+05 1.5E+03 7.4E+03 4.1E+03 3.6E+06 8.1E+03 4.5E+03 2.0E+05 5.4E+05 2.6E+03 5.2E+04\n305 NBCI 1.4E+05 6.5E+02 4.0E+03 3.2E+03 1.6E+06 ND 6.9E+02 4.1E+04 1.8E+05 1.3E+03 5.7E+03\n315 NBCI 4.2E+05 7.6E+03 5.1E+03 3.1E+03 7.9E+06 7.2E+03 4.3E+03 7.3E+04 4.5E+05 1.0E+04 3.8E+04\n330 NBCI 1.2E+05 2.0E+03 5.8E+03 3.5E+03 1.1E+06 3.1E+01 1.3E+03 2.9E+04 2.3E+05 1.4E+03 1.7E+04\n331 NBCI 6.1E+05 3.4E+03 1.3E+04 3.6E+03 7.3E+06 1.0E+04 1.8E+03 1.2E+05 1.3E+06 1.9E+03 5.7E+04\n334 NBCI 6.5E+05 4.0E+03 2.7E+04 1.7E+04 3.7E+06 4.6E+03 3.0E+03 6.8E+04 5.9E+05 2.9E+03 2.6E+04\n336 NBCI 4.7E+05 2.7E+03 4.4E+04 1.6E+03 3.4E+06 1.2E+04 8.3E+03 6.2E+04 5.4E+05 4.2E+03 1.2E+05\n337 NBCI 2.8E+05 2.8E+03 3.8E+03 4.3E+03 1.5E+06 5.3E+03 5.6E+03 4.9E+04 3.3E+05 1.7E+03 4.4E+04\n339 NBCI 3.1E+05 1.6E+04 3.0E+04 1.1E+03 3.5E+06 6.6E+03 2.0E+03 6.6E+04 2.4E+05 2.5E+03 2.2E+04\n361 NBCI 3.7E+05 8.4E+02 1.5E+04 1.3E+03 7.8E+06 3.1E+03 2.7E+03 4.8E+04 6.4E+05 6.1E+03 7.7E+04\n363 NBCI 6.1E+05 2.7E+03 2.2E+04 2.0E+03 8.1E+06 9.9E+03 2.4E+03 9.7E+04 7.0E+05 7.0E+03 3.6E+04\n34 BCI 8.8E+05 3.1E+03 3.4E+03 5.1E+02 1.8E+06 ND 1.9E+03 6.1E+04 2.9E+05 3.1E+03 5.6E+04\n71 BCI 8.8E+05 1.3E+04 3.2E+04 2.2E+03 6.7E+06 ND 2.5E+03 4.1E+05 7.5E+05 3.1E+03 5.6E+05\n85 BCI 2.3E+05 1.1E+03 2.6E+04 4.1E+03 1.2E+06 1.0E+04 8.1E+02 4.8E+04 1.5E+05 3.5E+03 1.8E+04\n88 BCI 1.3E+05 1.5E+03 3.5E+03 1.1E+03 6.9E+05 ND 5.6E+02 2.4E+04 1.9E+05 2.4E+03 1.6E+04\n99 BCI 9.0E+05 2.1E+03 1.5E+04 5.5E+03 9.6E+06 6.7E+03 8.0E+03 1.2E+05 9.4E+05 8.5E+03 4.7E+04\n118 BCI 8.0E+04 3.8E+03 1.1E+04 4.8E+03 1.7E+06 4.0E+03 4.5E+02 4.4E+04 1.7E+05 1.1E+03 6.1E+03\n146 BCI 4.1E+05 2.9E+04 4.7E+04 4.7E+02 2.0E+06 7.1E+03 1.6E+04 6.6E+04 1.7E+05 3.8E+04 6.5E+04\n147 BCI 4.1E+05 2.5E+03 8.2E+03 7.3E+02 8.8E+05 1.7E+03 1.3E+03 2.3E+04 6.5E+05 2.3E+02 7.4E+04\n158 BCI 2.6E+04 2.6E+03 1.4E+04 4.7E+03 2.3E+06 2.9E+03 1.2E+03 2.3E+04 3.7E+04 1.9E+03 2.3E+04\n167 BCI 1.9E+05 2.5E+03 5.3E+03 1.8E+03 2.4E+06 1.4E+04 2.3E+03 9.5E+04 4.0E+05 2.9E+03 2.8E+04\n171 BCI 1.6E+06 1.7E+03 1.6E+04 4.0E+03 7.8E+06 6.0E+03 6.5E+03 2.5E+05 1.4E+06 1.4E+04 6.0E+04\n191 BCI 4.5E+05 1.9E+03 3.5E+03 2.5E+02 1.7E+06 3.6E+03 5.6E+02 2.1E+04 1.6E+05 2.5E+03 2.1E+04\n211 BCI 6.0E+05 1.7E+04 1.1E+04 1.3E+02 1.0E+07 5.5E+03 4.1E+03 2.4E+04 7.1E+05 4.3E+03 8.3E+04\n212 BCI 6.5E+04 1.6E+03 9.6E+03 1.1E+03 4.0E+06 8.1E+03 9.5E+02 7.5E+04 9.4E+04 3.1E+03 3.6E+04\n247 BCI 2.3E+05 2.0E+02 1.4E+04 2.1E+03 1.3E+06 7.1E+03 1.1E+03 2.4E+04 1.3E+05 1.3E+03 1.1E+04\n255 BCI 1.3E+06 7.3E+03 1.5E+04 2.5E+03 2.8E+06 3.8E+04 8.1E+03 1.1E+05 2.8E+06 2.0E+03 1.0E+05\n259 BCI 3.0E+06 5.9E+03 1.4E+04 7.0E+03 9.2E+06 5.1E+03 5.1E+03 1.1E+05 5.0E+05 4.8E+03 2.1E+04\n271 BCI 7.4E+05 9.5E+02 3.8E+03 2.6E+03 2.4E+06 3.7E+03 3.1E+03 7.1E+04 6.3E+05 4.1E+03 3.0E+04\n287 BCI 5.8E+05 8.7E+03 1.1E+04 2.3E+03 1.9E+06 1.5E+04 6.3E+02 8.8E+04 1.2E+05 4.7E+03 3.3E+04\n300 BCI 2.7E+05 1.5E+03 7.7E+03 5.0E+03 3.7E+06 7.1E+03 1.9E+03 6.7E+04 3.2E+05 8.0E+02 1.3E+04\n306 BCI 4.2E+05 2.0E+02 9.7E+03 2.3E+03 2.2E+06 ND 4.8E+03 5.6E+04 1.1E+06 4.5E+02 1.9E+04\n314 BCI 1.6E+05 3.7E+03 1.7E+04 1.1E+03 1.2E+06 1.9E+02 1.5E+03 2.7E+04 2.7E+05 2.8E+03 3.4E+04\n329 BCI 2.3E+05 8.9E+03 1.6E+04 5.3E+03 7.2E+06 7.8E+03 1.4E+03 5.7E+04 8.9E+05 1.9E+03 4.8E+04\n335 BCI 4.1E+05 6.5E+03 2.1E+04 7.1E+03 4.3E+06 1.8E+02 7.0E+03 6.9E+04 5.2E+05 3.9E+03 4.4E+04\nB3 BCI 4.0E+05 3.2E+03 6.0E+03 3.8E+02 1.6E+06 7.7E+03 1.8E+03 1.8E+04 2.6E+05 3.7E+03 1.7E+04\nVirtually-multiplexed transcript abundance data for each gene (in the form of molecules/106 β-actin molecules) from all experiments were included in the same Standardized Expression Database (SED). These data are now directly comparable to previously published virtually-multiplexed transcript abundance data from this laboratory [15], or to Virtually-multiplexed transcript abundance data collected by others who use the NCI-funded (R24 CA 95806) Standardized Expression Measurement (SEM) Center. The data presented here represent more than 6,000 Virtually-multiplexed transcript abundance measurements conducted in multiple experiments. The sixteen antioxidant or DNA repair genes and each of the six transcription factors except for E2F1 were measured in each NBEC sample from 49 individuals (24 non-BC individuals and 25 BC individuals).\n1ND, Not detectable (When 60 molecules of Competitive Template (CT) were added to the reaction, CT was detected but native template was not.)\n2NA, Not available. E2F1 was measured in all of the samples except for one BC individual (24 non-BC individuals and 24 BC individuals).\nTable 4 Bivariate analysis of virtually-multiplexed transcript abundance data values for each antioxidant or DNA repair gene versus each transcription factor.\nNon-BC Individuals n = 24 BC Individuals n = 25 ALL n = 49\nAntioxidant/DNA Repair Genes vs Transcription Factors r Value p Value r Value p Value r Value p Value\nCAT vs CEBPB 0.13 1 0.18 1 0.15 1\nCAT vs CEBPG 0.65 0.004 0.35 0.48 0.55 \u003c0.0006\nCAT vs E2F1* 0.54 0.04 0.68 0.002 0.56 \u003c0.0006\nCAT vs E2F3 0.48 0.12 0.18 1 0.37 0.06\nCAT vs E2F6 0.26 1 0.3 0.84 0.25 0.48\nCAT vs EVI1 -0.01 1 0.21 1 0.08 1\nERCC1 vs CEBPB 0.32 0.78 0.27 1 0.29 0.24\nERCC1 vs CEBPG 0.77 \u003c0.0006 0.42 0.24 0.62 \u003c0.0006\nERCC1 vs E2F1 0.35 0.54 0.39 0.36 0.37 0.06\nERCC1 vs E2F3 0.39 0.36 0.21 1 0.31 0.18\nERCC1 vs E2F6 0.17 1 0.63 0.005 0.42 0.02\nERCC1 vs EVI1 -0.02 1 0.38 0.36 0.17 1\nERCC2 vs CEBPB 0.25 1 0.19 1 0.22 0.84\nERCC2 vs CEBPG 0.63 0.006 0.39 0.3 0.53 \u003c0.0006\nERCC2 vs E2F1 0.39 0.36 0.32 0.72 0.33 0.12\nERCC2 vs E2F3 0.58 0.02 0.22 1 0.42 0.02\nERCC2 vs E2F6 0.37 0.42 0.51 0.06 0.42 0.02\nERCC2 vs EVI1 0.19 1 0.29 0.96 0.23 0.66\nERCC4 vs CEBPB -0.35 0.6 -0.11 1 -0.16 1\nERCC4 vs CEBPG 0.24 1 0.37 0.42 0.25 0.48\nERCC4 vs E2F1 0.42 0.24 0.04 1 0.2 1\nERCC4 vs E2F3 0.6 0.01 0.33 0.6 0.33 0.12\nERCC4 vs E2F6 -0.04 1 0.04 1 0.07 1\nERCC4 vs EVI1 0.24 1 0.33 0.66 0.27 0.36\nERCC5 vs CEBPB 0.4 0.3 0.28 1 0.33 0.12\nERCC5 vs CEBPG 0.79 \u003c0.0006 0.12 1 0.46 0.005\nERCC5 vs E2F1 0.44 0.18 0.45 0.18 0.44 0.01\nERCC5 vs E2F3 0.39 0.36 -0.11 1 0.13 1\nERCC5 vs E2F6 0.41 0.3 0.35 0.54 0.38 0.04\nERCC5 vs EVI1 0.07 1 -0.04 1 0.01 1\nGPX1 vs CEBPB 0.49 0.06 0.24 1 0.32 0.12\nGPX1 vs CEBPG 0.72 \u003c0.0006 0.19 1 0.4 0.02\nGPX1 vs E2F1 0.48 0.12 0.38 0.36 0.43 0.02\nGPX1 vs E2F3 0.22 1 -0.004 1 0.08 1\nGPX1 vs E2F6 0.06 1 0.36 0.48 0.28 0.3\nGPX1 vs EVI1 -0.06 1 0.2 1 0.1 1\nGPX3 vs CEBPB -0.18 1 0.14 1 0.02 1\nGPX3 vs CEBPG 0.13 1 0.01 1 0.07 1\nGPX3 vs E2F1 -0.03 1 -0.17 1 -0.12 1\nGPX3 vs E2F3 0.32 0.78 -0.2 1 0.05 1\nGPX3 vs E2F6 -0.26 1 0.44 0.18 0.19 1\nGPX3 vs EVI1 0.06 1 0.08 1 0.06 1\nGSTM1-5 vs CEBPB -0.08 1 0.43 0.18 0.17 1\nGSTM1-5 vs CEBPG 0.25 1 0.02 1 0.16 1\nGSTM1-5 vs E2F1 0.51 0.06 0.23 1 0.41 0.02\nGSTM1-5 vs E2F3 0.29 0.96 -0.16 1 0.1 1\nGSTM1-5 vs E2F6 -0.3 0.9 0.006 1 -0.1 1\nGSTM1-5 vs EVI1 0.22 1 -0.12 1 0.07 1\nGSTM3 vs CEBPB 0.01 1 0.06 1 0.04 1\nGSTM3 vs CEBPG -0.007 1 -0.28 1 0.01 1\nGSTM3 vs E2F1 0.29 1 0.35 0.54 0.34 0.12\nGSTM3 vs E2F3 -0.31 0.84 -0.49 0.06 -0.4 0.03\nGSTM3 vs E2F6 -0.11 1 -0.25 1 -0.16 1\nGSTM3 vs EVI1 -0.27 1 -0.25 1 -0.25 0.54\nGSTP1 vs CEBPB 0.19 1 0.38 0.36 0.28 0.36\nGSTP1 vs CEBPG 0.74 \u003c0.0006 0.18 1 0.51 0.001\nGSTP1 vs E2F1 0.6 0.01 0.46 0.12 0.56 \u003c0.0006\nGSTP1 vs E2F3 0.32 0.78 -0.25 1 0.07 1\nGSTP1 vs E2F6 0.1 1 0.35 0.48 0.26 0.42\nGSTP1 vs EVI1 0.11 1 0.13 1 0.12 1\nGSTT1 vs CEBPB 0.03 1 0.45 0.12 0.24 0.6\nGSTT1 vs CEBPG 0.39 0.36 0.16 1 0.3 0.24\nGSTT1 vs E2F1 0.07 1 -0.15 1 -0.05 1\nGSTT1 vs E2F3 0.35 0.54 -0.1 1 0.17 1\nGSTT1 vs E2F6 0.05 1 0.21 1 0.11 1\nGSTT1 vs EVI1 -0.26 1 0.22 1 -0.04 1\nGSTZ1 vs CEBPB 0.11 1 0.36 0.42 0.25 0.54\nGSTZ1 vs CEBPG 0.51 0.06 0.08 1 0.28 0.3\nGSTZ1 vs E2F1 0.64 0.004 0.5 0.06 0.58 \u003c0.0006\nGSTZ1 vs E2F3 0.42 0.24 0.14 1 0.25 0.54\nGSTZ1 vs E2F6 -0.05 1 0.48 0.12 0.32 0.18\nGSTZ1 vs EVI1 0.02 1 0.27 1 0.16 1\nmGST vs CEBPB 0.31 0.78 0.35 0.48 0.32 0.12\nmGST vs CEBPG 0.56 0.02 0.25 1 0.42 0.02\nmGST vs E2F1 0.58 0.02 0.54 0.04 0.58 \u003c0.0006\nmGST vs E2F3 0.03 1 -0.15 1 -0.06 1\nmGST vs E2F6 0.17 1 0.29 0.96 0.27 0.36\nmGST vs EVI1 -0.16 1 0.07 1 -0.04 1\nSOD1 vs CEBPB 0.13 1 0.15 1 0.14 1\nSOD1 vs CEBPG 0.66 0.002 0.009 1 0.36 0.06\nSOD1 vs E2F1 0.59 0.02 0.55 0.04 0.56 \u003c0.0006\nSOD1 vs E2F3 0.25 1 -0.07 1 0.09 1\nSOD1 vs E2F6 0.12 1 0.14 1 0.14 1\nSOD1 vs EVI1 -0.17 1 0.03 1 -0.06 1\nXPA vs CEBPB 0.31 0.84 0.42 0.24 0.31 0.18\nXPA vs CEBPG 0.36 0.54 0.33 0.66 0.34 0.12\nXPA vs E2F1 -0.05 1 0.22 1 -0.02 1\nXPA vs E2F3 -0.07 1 0.14 1 -0.01 1\nXPA vs E2F6 0.55 0.04 0.46 0.12 0.4 0.02\nXPA vs EVI1 0.04 1 0.07 1 0.04 1\nXRCC1 vs CEBPB 0.36 0.48 0.28 1 0.32 0.18\nXRCC1 vs CEBPG 0.83 \u003c0.0006 0.27 1 0.591 \u003c0.0006\nXRCC1 vs E2F1 0.32 0.78 0.37 0.48 0.35 0.12\nXRCC1 vs E2F3 0.47 0.12 0.22 1 0.35 0.06\nXRCC1 vs E2F6 0.26 1 0.54 0.04 0.41 0.02\nXRCC1 vs EVI1 -0.009 1 0.12 1 0.06 1\nThe correlation of logarithmically transformed virtually-multiplexed transcript abundance data (Table 3) from each of the six transcription factors with each of the sixteen antioxidant or DNA repair genes was determined. The transformation was necessary due to the wide range of expression of each gene among the samples. The correlation coefficient (r value) and level of significance (p value) for each correlation are presented. Significance (p \u003c 0.01) was determined using a two-tailed test following Bonferroni adjustment for six multiple comparisons (comparison of each of six transcription factors to each of the antioxidant or DNA repair genes).\n*values for E2F1 obtained in all but one BC 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