Id |
Subject |
Object |
Predicate |
Lexical cue |
T292 |
0-9 |
NN |
denotes |
Cigarette |
T293 |
10-17 |
NN |
denotes |
smoking |
T294 |
18-20 |
VBZ |
denotes |
is |
T295 |
21-24 |
DT |
denotes |
the |
T296 |
33-38 |
NN |
denotes |
cause |
T297 |
25-32 |
JJ |
denotes |
primary |
T298 |
39-41 |
IN |
denotes |
of |
T299 |
42-54 |
JJ |
denotes |
bronchogenic |
T300 |
55-64 |
NN |
denotes |
carcinoma |
T301 |
65-66 |
-LRB- |
denotes |
( |
T302 |
66-68 |
NN |
denotes |
BC |
T303 |
68-69 |
-RRB- |
denotes |
) |
T304 |
69-71 |
, |
denotes |
, |
T305 |
71-74 |
CC |
denotes |
yet |
T306 |
75-79 |
RB |
denotes |
only |
T307 |
83-85 |
CD |
denotes |
15 |
T308 |
80-82 |
CD |
denotes |
10 |
T309 |
82-83 |
SYM |
denotes |
– |
T310 |
85-86 |
NN |
denotes |
% |
T311 |
104-111 |
VBP |
denotes |
develop |
T312 |
87-89 |
IN |
denotes |
of |
T313 |
90-95 |
JJ |
denotes |
heavy |
T314 |
96-103 |
NNS |
denotes |
smokers |
T315 |
112-114 |
NN |
denotes |
BC |
T316 |
115-118 |
CC |
denotes |
and |
T317 |
119-121 |
PRP |
denotes |
it |
T318 |
122-124 |
VBZ |
denotes |
is |
T319 |
125-131 |
JJ |
denotes |
likely |
T320 |
132-136 |
IN |
denotes |
that |
T321 |
185-195 |
VBN |
denotes |
determined |
T322 |
137-141 |
DT |
denotes |
this |
T323 |
142-151 |
NN |
denotes |
variation |
T324 |
152-154 |
IN |
denotes |
in |
T325 |
155-159 |
NN |
denotes |
risk |
T326 |
160-162 |
VBZ |
denotes |
is |
T327 |
162-164 |
, |
denotes |
, |
T328 |
164-166 |
IN |
denotes |
in |
T329 |
167-171 |
JJ |
denotes |
part |
T330 |
171-173 |
, |
denotes |
, |
T331 |
173-184 |
RB |
denotes |
genetically |
T332 |
195-196 |
. |
denotes |
. |
T333 |
196-381 |
sentence |
denotes |
We previously reported a set of antioxidant genes for which transcript abundance was lower in normal bronchial epithelial cells (NBEC) of BC individuals compared to non-BC individuals. |
T334 |
197-199 |
PRP |
denotes |
We |
T335 |
211-219 |
VBD |
denotes |
reported |
T336 |
200-210 |
RB |
denotes |
previously |
T337 |
220-221 |
DT |
denotes |
a |
T338 |
222-225 |
NN |
denotes |
set |
T339 |
226-228 |
IN |
denotes |
of |
T340 |
229-240 |
NN |
denotes |
antioxidant |
T341 |
241-246 |
NNS |
denotes |
genes |
T342 |
247-250 |
IN |
denotes |
for |
T343 |
278-281 |
VBD |
denotes |
was |
T344 |
251-256 |
WDT |
denotes |
which |
T345 |
257-267 |
NN |
denotes |
transcript |
T346 |
268-277 |
NN |
denotes |
abundance |
T347 |
282-287 |
JJR |
denotes |
lower |
T348 |
288-290 |
IN |
denotes |
in |
T349 |
291-297 |
JJ |
denotes |
normal |
T350 |
319-324 |
NNS |
denotes |
cells |
T351 |
298-307 |
JJ |
denotes |
bronchial |
T352 |
308-318 |
JJ |
denotes |
epithelial |
T353 |
325-326 |
-LRB- |
denotes |
( |
T354 |
326-330 |
NN |
denotes |
NBEC |
T355 |
330-331 |
-RRB- |
denotes |
) |
T356 |
332-334 |
IN |
denotes |
of |
T357 |
335-337 |
NN |
denotes |
BC |
T358 |
338-349 |
NNS |
denotes |
individuals |
T359 |
350-358 |
VBN |
denotes |
compared |
T360 |
359-361 |
IN |
denotes |
to |
T361 |
362-368 |
JJ |
denotes |
non-BC |
T362 |
369-380 |
NNS |
denotes |
individuals |
T363 |
380-381 |
. |
denotes |
. |
T364 |
381-533 |
sentence |
denotes |
In unpublished studies of the same NBEC samples, transcript abundance values for several DNA repair genes were correlated with these antioxidant genes. |
T365 |
382-384 |
IN |
denotes |
In |
T366 |
493-503 |
VBN |
denotes |
correlated |
T367 |
385-396 |
JJ |
denotes |
unpublished |
T368 |
397-404 |
NNS |
denotes |
studies |
T369 |
405-407 |
IN |
denotes |
of |
T370 |
408-411 |
DT |
denotes |
the |
T371 |
422-429 |
NNS |
denotes |
samples |
T372 |
412-416 |
JJ |
denotes |
same |
T373 |
417-421 |
NN |
denotes |
NBEC |
T374 |
429-431 |
, |
denotes |
, |
T375 |
431-441 |
NN |
denotes |
transcript |
T376 |
452-458 |
NNS |
denotes |
values |
T377 |
442-451 |
NN |
denotes |
abundance |
T378 |
459-462 |
IN |
denotes |
for |
T379 |
463-470 |
JJ |
denotes |
several |
T380 |
482-487 |
NNS |
denotes |
genes |
T381 |
471-474 |
NN |
denotes |
DNA |
T382 |
475-481 |
NN |
denotes |
repair |
T383 |
488-492 |
VBD |
denotes |
were |
T384 |
504-508 |
IN |
denotes |
with |
T385 |
509-514 |
DT |
denotes |
these |
T386 |
527-532 |
NNS |
denotes |
genes |
T387 |
515-526 |
NN |
denotes |
antioxidant |
T388 |
532-533 |
. |
denotes |
. |
T389 |
533-832 |
sentence |
denotes |
From these data, we hypothesized that antioxidant and DNA repair genes are co-regulated by one or more transcription factors and that inter-individual variation in expression and/or function of one or more of these transcription factors is responsible for inter-individual variation in risk for BC. |
T390 |
534-538 |
IN |
denotes |
From |
T391 |
554-566 |
VBD |
denotes |
hypothesized |
T392 |
539-544 |
DT |
denotes |
these |
T393 |
545-549 |
NNS |
denotes |
data |
T394 |
549-551 |
, |
denotes |
, |
T395 |
551-553 |
PRP |
denotes |
we |
T396 |
567-571 |
IN |
denotes |
that |
T397 |
609-621 |
VBN |
denotes |
co-regulated |
T398 |
572-583 |
NN |
denotes |
antioxidant |
T399 |
599-604 |
NNS |
denotes |
genes |
T400 |
584-587 |
CC |
denotes |
and |
T401 |
588-591 |
NN |
denotes |
DNA |
T402 |
592-598 |
NN |
denotes |
repair |
T403 |
605-608 |
VBP |
denotes |
are |
T404 |
622-624 |
IN |
denotes |
by |
T405 |
625-628 |
CD |
denotes |
one |
T406 |
651-658 |
NNS |
denotes |
factors |
T407 |
629-631 |
CC |
denotes |
or |
T408 |
632-636 |
JJR |
denotes |
more |
T409 |
637-650 |
NN |
denotes |
transcription |
T410 |
659-662 |
CC |
denotes |
and |
T411 |
663-667 |
IN |
denotes |
that |
T412 |
771-773 |
VBZ |
denotes |
is |
T413 |
668-684 |
JJ |
denotes |
inter-individual |
T414 |
685-694 |
NN |
denotes |
variation |
T415 |
695-697 |
IN |
denotes |
in |
T416 |
698-708 |
NN |
denotes |
expression |
T417 |
709-712 |
CC |
denotes |
and |
T418 |
712-713 |
HYPH |
denotes |
/ |
T419 |
713-715 |
CC |
denotes |
or |
T420 |
716-724 |
NN |
denotes |
function |
T421 |
725-727 |
IN |
denotes |
of |
T422 |
728-731 |
CD |
denotes |
one |
T423 |
732-734 |
CC |
denotes |
or |
T424 |
735-739 |
JJR |
denotes |
more |
T425 |
740-742 |
IN |
denotes |
of |
T426 |
743-748 |
DT |
denotes |
these |
T427 |
763-770 |
NNS |
denotes |
factors |
T428 |
749-762 |
NN |
denotes |
transcription |
T429 |
774-785 |
JJ |
denotes |
responsible |
T430 |
786-789 |
IN |
denotes |
for |
T431 |
790-806 |
JJ |
denotes |
inter-individual |
T432 |
807-816 |
NN |
denotes |
variation |
T433 |
817-819 |
IN |
denotes |
in |
T434 |
820-824 |
NN |
denotes |
risk |
T435 |
825-828 |
IN |
denotes |
for |
T436 |
829-831 |
NN |
denotes |
BC |
T437 |
831-832 |
. |
denotes |
. |
R94 |
T370 |
T371 |
det |
the,samples |
R95 |
T371 |
T369 |
pobj |
samples,of |
R21 |
T292 |
T293 |
compound |
Cigarette,smoking |
R22 |
T293 |
T294 |
nsubj |
smoking,is |
R23 |
T295 |
T296 |
det |
the,cause |
R24 |
T296 |
T294 |
attr |
cause,is |
R26 |
T298 |
T296 |
prep |
of,cause |
R27 |
T299 |
T300 |
amod |
bronchogenic,carcinoma |
R28 |
T300 |
T298 |
pobj |
carcinoma,of |
R29 |
T301 |
T300 |
punct |
(,carcinoma |
R30 |
T302 |
T300 |
appos |
BC,carcinoma |
R31 |
T303 |
T294 |
punct |
),is |
R32 |
T304 |
T294 |
punct |
", ",is |
R33 |
T305 |
T294 |
cc |
yet,is |
R34 |
T306 |
T307 |
advmod |
only,15 |
R35 |
T307 |
T310 |
nummod |
15,% |
R38 |
T310 |
T311 |
nsubj |
%,develop |
R39 |
T311 |
T294 |
conj |
develop,is |
R43 |
T315 |
T311 |
dobj |
BC,develop |
R44 |
T316 |
T311 |
cc |
and,develop |
R45 |
T317 |
T318 |
nsubj |
it,is |
R46 |
T318 |
T311 |
conj |
is,develop |
R47 |
T319 |
T318 |
acomp |
likely,is |
R48 |
T320 |
T321 |
mark |
that,determined |
R49 |
T321 |
T318 |
ccomp |
determined,is |
R60 |
T332 |
T311 |
punct |
.,develop |
R61 |
T334 |
T335 |
nsubj |
We,reported |
R62 |
T336 |
T335 |
advmod |
previously,reported |
R63 |
T337 |
T338 |
det |
a,set |
R64 |
T338 |
T335 |
dobj |
set,reported |
R65 |
T339 |
T338 |
prep |
of,set |
R66 |
T340 |
T341 |
compound |
antioxidant,genes |
R67 |
T341 |
T339 |
pobj |
genes,of |
R68 |
T342 |
T343 |
prep |
for,was |
R69 |
T343 |
T341 |
relcl |
was,genes |
R73 |
T347 |
T343 |
acomp |
lower,was |
R74 |
T348 |
T343 |
prep |
in,was |
R75 |
T349 |
T350 |
amod |
normal,cells |
R76 |
T350 |
T348 |
pobj |
cells,in |
R79 |
T353 |
T350 |
punct |
(,cells |
R80 |
T354 |
T350 |
appos |
NBEC,cells |
R81 |
T355 |
T350 |
punct |
),cells |
R82 |
T356 |
T350 |
prep |
of,cells |
R83 |
T357 |
T358 |
compound |
BC,individuals |
R84 |
T358 |
T356 |
pobj |
individuals,of |
R85 |
T359 |
T343 |
prep |
compared,was |
R86 |
T360 |
T359 |
prep |
to,compared |
R87 |
T361 |
T362 |
amod |
non-BC,individuals |
R88 |
T362 |
T360 |
pobj |
individuals,to |
R89 |
T363 |
T335 |
punct |
.,reported |
R90 |
T365 |
T366 |
prep |
In,correlated |
R91 |
T367 |
T368 |
amod |
unpublished,studies |
R92 |
T368 |
T365 |
pobj |
studies,In |
R93 |
T369 |
T368 |
prep |
of,studies |
R98 |
T374 |
T366 |
punct |
", ",correlated |
R99 |
T375 |
T376 |
compound |
transcript,values |
R100 |
T376 |
T366 |
nsubjpass |
values,correlated |
R102 |
T378 |
T376 |
prep |
for,values |
R103 |
T379 |
T380 |
amod |
several,genes |
R104 |
T380 |
T378 |
pobj |
genes,for |
R107 |
T383 |
T366 |
auxpass |
were,correlated |
R108 |
T384 |
T366 |
prep |
with,correlated |
R109 |
T385 |
T386 |
det |
these,genes |
R110 |
T386 |
T384 |
pobj |
genes,with |
R112 |
T388 |
T366 |
punct |
.,correlated |
R113 |
T390 |
T391 |
prep |
From,hypothesized |
R114 |
T392 |
T393 |
det |
these,data |
R115 |
T393 |
T390 |
pobj |
data,From |
R116 |
T394 |
T391 |
punct |
", ",hypothesized |
R117 |
T395 |
T391 |
nsubj |
we,hypothesized |
R118 |
T396 |
T397 |
mark |
that,co-regulated |
R119 |
T397 |
T391 |
advcl |
co-regulated,hypothesized |
R121 |
T399 |
T397 |
nsubjpass |
genes,co-regulated |
R122 |
T400 |
T398 |
cc |
and,antioxidant |
R123 |
T401 |
T402 |
compound |
DNA,repair |
R124 |
T402 |
T398 |
conj |
repair,antioxidant |
R126 |
T404 |
T397 |
agent |
by,co-regulated |
R127 |
T405 |
T406 |
nummod |
one,factors |
R128 |
T406 |
T404 |
pobj |
factors,by |
R132 |
T410 |
T397 |
cc |
and,co-regulated |
R133 |
T411 |
T412 |
mark |
that,is |
R134 |
T412 |
T397 |
conj |
is,co-regulated |
R149 |
T427 |
T425 |
pobj |
factors,of |
R150 |
T428 |
T427 |
compound |
transcription,factors |
R151 |
T429 |
T412 |
acomp |
responsible,is |
R152 |
T430 |
T429 |
prep |
for,responsible |
R153 |
T431 |
T432 |
amod |
inter-individual,variation |
R154 |
T432 |
T430 |
pobj |
variation,for |
R155 |
T433 |
T432 |
prep |
in,variation |
R156 |
T434 |
T433 |
pobj |
risk,in |
R157 |
T435 |
T434 |
prep |
for,risk |
R158 |
T436 |
T435 |
pobj |
BC,for |
R159 |
T437 |
T391 |
punct |
.,hypothesized |
R25 |
T297 |
T296 |
amod |
primary,cause |
R36 |
T308 |
T307 |
quantmod |
10,15 |
R37 |
T309 |
T307 |
punct |
–,15 |
R40 |
T312 |
T310 |
prep |
of,% |
R41 |
T313 |
T314 |
amod |
heavy,smokers |
R42 |
T314 |
T312 |
pobj |
smokers,of |
R50 |
T322 |
T323 |
det |
this,variation |
R51 |
T323 |
T321 |
nsubjpass |
variation,determined |
R52 |
T324 |
T323 |
prep |
in,variation |
R53 |
T325 |
T324 |
pobj |
risk,in |
R54 |
T326 |
T321 |
auxpass |
is,determined |
R55 |
T327 |
T321 |
punct |
", ",determined |
R56 |
T328 |
T321 |
prep |
in,determined |
R57 |
T329 |
T328 |
amod |
part,in |
R58 |
T330 |
T321 |
punct |
", ",determined |
R59 |
T331 |
T321 |
advmod |
genetically,determined |
R70 |
T344 |
T342 |
pobj |
which,for |
R71 |
T345 |
T346 |
compound |
transcript,abundance |
R72 |
T346 |
T343 |
nsubj |
abundance,was |
R77 |
T351 |
T350 |
amod |
bronchial,cells |
R78 |
T352 |
T350 |
amod |
epithelial,cells |
R96 |
T372 |
T371 |
amod |
same,samples |
R97 |
T373 |
T371 |
compound |
NBEC,samples |
R101 |
T377 |
T376 |
compound |
abundance,values |
R105 |
T381 |
T382 |
compound |
DNA,repair |
R106 |
T382 |
T380 |
compound |
repair,genes |
R111 |
T387 |
T386 |
compound |
antioxidant,genes |
R120 |
T398 |
T399 |
nmod |
antioxidant,genes |
R125 |
T403 |
T397 |
auxpass |
are,co-regulated |
R129 |
T407 |
T405 |
cc |
or,one |
R130 |
T408 |
T405 |
conj |
more,one |
R131 |
T409 |
T406 |
compound |
transcription,factors |
R135 |
T413 |
T414 |
amod |
inter-individual,variation |
R136 |
T414 |
T412 |
nsubj |
variation,is |
R137 |
T415 |
T414 |
prep |
in,variation |
R138 |
T416 |
T415 |
pobj |
expression,in |
R139 |
T417 |
T416 |
cc |
and,expression |
R140 |
T418 |
T417 |
punct |
/,and |
R141 |
T419 |
T417 |
cc |
or,and |
R142 |
T420 |
T416 |
conj |
function,expression |
R143 |
T421 |
T416 |
prep |
of,expression |
R144 |
T422 |
T421 |
pobj |
one,of |
R145 |
T423 |
T422 |
cc |
or,one |
R146 |
T424 |
T422 |
conj |
more,one |
R147 |
T425 |
T422 |
prep |
of,one |
R148 |
T426 |
T427 |
det |
these,factors |