PMC:1283364 / 3829-4147
Annnotations
craft-sa-dev
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protein APP. Peptide Aβ is released from APP by the action of two enzymes, the β-APP cleaving enzyme 1 (BACE1) and γ-secretase, which cleave the holoprotein at the N- and C-termini of Aβ, respectively. Several inhibitors of γ-secretase have already been produced [8,9], and small molecule inhibitors of β-APP cleavin"}
2_test
{"project":"2_test","denotations":[{"id":"16279840-12052174-86242748","span":{"begin":266,"end":267},"obj":"12052174"},{"id":"16279840-12415246-86242749","span":{"begin":268,"end":269},"obj":"12415246"},{"id":"T59505","span":{"begin":266,"end":267},"obj":"12052174"},{"id":"T70543","span":{"begin":268,"end":269},"obj":"12415246"}],"text":"r protein APP. Peptide Aβ is released from APP by the action of two enzymes, the β-APP cleaving enzyme 1 (BACE1) and γ-secretase, which cleave the holoprotein at the N- and C-termini of Aβ, respectively. Several inhibitors of γ-secretase have already been produced [8,9], and small molecule inhibitors of β-APP cleavin"}
craft-ca-core-ex-dev
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craft-ca-core-dev
{"project":"craft-ca-core-dev","denotations":[{"id":"T567","span":{"begin":10,"end":13},"obj":"PR:000004168"},{"id":"T568","span":{"begin":43,"end":46},"obj":"PR:000004168"},{"id":"T569","span":{"begin":81,"end":104},"obj":"PR:000004615"},{"id":"T570","span":{"begin":87,"end":95},"obj":"MOP:0000780"},{"id":"T571","span":{"begin":106,"end":111},"obj":"PR:000004615"},{"id":"T572","span":{"begin":117,"end":128},"obj":"GO:0070765"},{"id":"T573","span":{"begin":136,"end":142},"obj":"MOP:0000780"},{"id":"T574","span":{"begin":147,"end":158},"obj":"CHEBI:33837"},{"id":"T575","span":{"begin":212,"end":222},"obj":"CHEBI:35222"},{"id":"T576","span":{"begin":226,"end":237},"obj":"GO:0070765"},{"id":"T577","span":{"begin":282,"end":290},"obj":"CHEBI:36357"},{"id":"T578","span":{"begin":291,"end":301},"obj":"CHEBI:35222"}],"text":"r protein APP. Peptide Aβ is released from APP by the action of two enzymes, the β-APP cleaving enzyme 1 (BACE1) and γ-secretase, which cleave the holoprotein at the N- and C-termini of Aβ, respectively. Several inhibitors of γ-secretase have already been produced [8,9], and small molecule inhibitors of β-APP cleavin"}