PMC:1271393 / 3263-3951 JSONTXT

{"project":"2_test","denotations":[{"id":"16252244-10922424-2049568","span":{"begin":169,"end":173},"obj":"10922424"},{"id":"16252244-11951031-2049569","span":{"begin":175,"end":179},"obj":"11951031"},{"id":"16252244-11861602-2049570","span":{"begin":203,"end":207},"obj":"11861602"},{"id":"16252244-11283698-2049571","span":{"begin":476,"end":480},"obj":"11283698"},{"id":"16252244-11861602-2049572","span":{"begin":504,"end":508},"obj":"11861602"}],"text":"The phylogenetically ancient innate immune system governs the initial detection of pathogens and stimulates the first line of host defense (Medzhitov and Janeway 1998a, 2000, 2002; Janeway and Medzhitov 2002). Recognition of pathogens is mediated by phagocytic cells through germline-encoded receptors, known as “pattern recognition receptors,” which detect pathogen-associated molecular patterns that are characteristic products of microbial physiology (Kimbrell and Beutler 2001; Janeway and Medzhitov 2002). This initial interaction is then translated into a set of endogenous signals that ultimately lead to the induction of the adaptive immune response (Medzhitov and Janeway 1998b)."}