PMC:1253828 / 35289-35979 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1253828","sourcedb":"PMC","sourceid":"1253828","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1253828","text":"The present study confirms and extends the role of MTF-1 as an important stress response regulator. We have identified and preliminarily characterized four target genes of MTF-1 in the adult mouse liver: in the case of Sepw1, MTF-1 is required to maintain basal expression, supporting a role of mouse MTF-1 in oxidative stress response. In addition, MTF-1 contributes to the cadmium-induced expression of Ndrg1 and Csrp1. Furthermore, MTF-1 helps to repress the basal expression of Slc39a10, in contrast to its role as transcriptional activator for genes like Mt1, Mt2 or Znt1. 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