PMC:1253828 / 2876-4204 JSONTXT

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In contrast, mice with null mutations for the stress-inducible metallothionein genes (Mt1 and Mt2) are viable, though sensitive to cadmium (24,25), indicating that additional important MTF-1 target genes are involved in the lethal phenotype. With the Cre-loxP conditional knockout technique, it is possible to circumvent the embryonic lethal phenotype of conventional Mtf1 knockout mice. 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