Id |
Subject |
Object |
Predicate |
Lexical cue |
T1215 |
0-3 |
DT |
denotes |
The |
T1216 |
4-8 |
NN |
denotes |
role |
T1217 |
27-34 |
VBN |
denotes |
studied |
T1218 |
9-11 |
IN |
denotes |
of |
T1219 |
12-15 |
NN |
denotes |
MTF |
T1220 |
15-16 |
HYPH |
denotes |
- |
T1221 |
16-17 |
CD |
denotes |
1 |
T1222 |
18-21 |
VBZ |
denotes |
has |
T1223 |
22-26 |
VBN |
denotes |
been |
T1224 |
35-39 |
RBS |
denotes |
most |
T1225 |
40-51 |
RB |
denotes |
extensively |
T1226 |
52-54 |
IN |
denotes |
in |
T1227 |
55-58 |
DT |
denotes |
the |
T1228 |
59-64 |
NN |
denotes |
mouse |
T1229 |
64-65 |
. |
denotes |
. |
T1230 |
65-242 |
sentence |
denotes |
Besides coping with heavy metal load, MTF-1 can also mediate the induction of Mt genes in response to other stress situations, such as oxidative stress (5,17) and hypoxia (18). |
T1231 |
66-73 |
IN |
denotes |
Besides |
T1232 |
119-126 |
VB |
denotes |
mediate |
T1233 |
74-80 |
VBG |
denotes |
coping |
T1234 |
81-85 |
IN |
denotes |
with |
T1235 |
86-91 |
JJ |
denotes |
heavy |
T1236 |
92-97 |
NN |
denotes |
metal |
T1237 |
98-102 |
NN |
denotes |
load |
T1238 |
102-104 |
, |
denotes |
, |
T1239 |
104-107 |
NN |
denotes |
MTF |
T1240 |
107-108 |
HYPH |
denotes |
- |
T1241 |
108-109 |
CD |
denotes |
1 |
T1242 |
110-113 |
MD |
denotes |
can |
T1243 |
114-118 |
RB |
denotes |
also |
T1244 |
127-130 |
DT |
denotes |
the |
T1245 |
131-140 |
NN |
denotes |
induction |
T1246 |
141-143 |
IN |
denotes |
of |
T1247 |
144-146 |
NN |
denotes |
Mt |
T1248 |
147-152 |
NNS |
denotes |
genes |
T1249 |
153-155 |
IN |
denotes |
in |
T1250 |
156-164 |
NN |
denotes |
response |
T1251 |
165-167 |
IN |
denotes |
to |
T1252 |
168-173 |
JJ |
denotes |
other |
T1253 |
181-191 |
NNS |
denotes |
situations |
T1254 |
174-180 |
NN |
denotes |
stress |
T1255 |
191-193 |
, |
denotes |
, |
T1256 |
193-197 |
JJ |
denotes |
such |
T1257 |
198-200 |
IN |
denotes |
as |
T1258 |
201-210 |
JJ |
denotes |
oxidative |
T1259 |
211-217 |
NN |
denotes |
stress |
T1260 |
218-219 |
-LRB- |
denotes |
( |
T1261 |
221-223 |
CD |
denotes |
17 |
T1262 |
219-220 |
CD |
denotes |
5 |
T1263 |
220-221 |
, |
denotes |
, |
T1264 |
223-224 |
-RRB- |
denotes |
) |
T1265 |
225-228 |
CC |
denotes |
and |
T1266 |
229-236 |
NN |
denotes |
hypoxia |
T1267 |
237-238 |
-LRB- |
denotes |
( |
T1268 |
238-240 |
CD |
denotes |
18 |
T1269 |
240-241 |
-RRB- |
denotes |
) |
T1270 |
241-242 |
. |
denotes |
. |
T1271 |
242-601 |
sentence |
denotes |
In addition, it is required for the metalloregulation of Znt1, encoding the major plasma membrane-localized zinc efflux transporter (19), the hypoxic/anoxic induction of the gene for placental growth factor (Plgf), an angiogenic protein of the vascular endothelial growth factor (VEGF) family (20), and has recently been invoked in tumor development (21,22). |
T1272 |
243-245 |
IN |
denotes |
In |
T1273 |
262-270 |
VBN |
denotes |
required |
T1274 |
246-254 |
NN |
denotes |
addition |
T1275 |
254-256 |
, |
denotes |
, |
T1276 |
256-258 |
PRP |
denotes |
it |
T1277 |
259-261 |
VBZ |
denotes |
is |
T1278 |
271-274 |
IN |
denotes |
for |
T1279 |
275-278 |
DT |
denotes |
the |
T1280 |
279-296 |
NN |
denotes |
metalloregulation |
T1281 |
297-299 |
IN |
denotes |
of |
T1282 |
300-304 |
NN |
denotes |
Znt1 |
T1283 |
304-306 |
, |
denotes |
, |
T1284 |
306-314 |
VBG |
denotes |
encoding |
T1285 |
315-318 |
DT |
denotes |
the |
T1286 |
363-374 |
NN |
denotes |
transporter |
T1287 |
319-324 |
JJ |
denotes |
major |
T1288 |
325-331 |
NN |
denotes |
plasma |
T1289 |
332-340 |
NN |
denotes |
membrane |
T1290 |
341-350 |
VBN |
denotes |
localized |
T1291 |
340-341 |
HYPH |
denotes |
- |
T1292 |
351-355 |
NN |
denotes |
zinc |
T1293 |
356-362 |
NN |
denotes |
efflux |
T1294 |
375-376 |
-LRB- |
denotes |
( |
T1295 |
376-378 |
CD |
denotes |
19 |
T1296 |
378-379 |
-RRB- |
denotes |
) |
T1297 |
379-381 |
, |
denotes |
, |
T1298 |
381-384 |
DT |
denotes |
the |
T1299 |
400-409 |
NN |
denotes |
induction |
T1300 |
385-392 |
JJ |
denotes |
hypoxic |
T1301 |
393-399 |
JJ |
denotes |
anoxic |
T1302 |
392-393 |
HYPH |
denotes |
/ |
T1303 |
410-412 |
IN |
denotes |
of |
T1304 |
413-416 |
DT |
denotes |
the |
T1305 |
417-421 |
NN |
denotes |
gene |
T1306 |
422-425 |
IN |
denotes |
for |
T1307 |
426-435 |
JJ |
denotes |
placental |
T1308 |
443-449 |
NN |
denotes |
factor |
T1309 |
436-442 |
NN |
denotes |
growth |
T1310 |
450-451 |
-LRB- |
denotes |
( |
T1311 |
451-455 |
NN |
denotes |
Plgf |
T1312 |
455-456 |
-RRB- |
denotes |
) |
T1313 |
456-458 |
, |
denotes |
, |
T1314 |
458-460 |
DT |
denotes |
an |
T1315 |
472-479 |
NN |
denotes |
protein |
T1316 |
461-471 |
JJ |
denotes |
angiogenic |
T1317 |
480-482 |
IN |
denotes |
of |
T1318 |
483-486 |
DT |
denotes |
the |
T1319 |
529-535 |
NN |
denotes |
family |
T1320 |
487-495 |
JJ |
denotes |
vascular |
T1321 |
515-521 |
NN |
denotes |
factor |
T1322 |
496-507 |
JJ |
denotes |
endothelial |
T1323 |
508-514 |
NN |
denotes |
growth |
T1324 |
522-523 |
-LRB- |
denotes |
( |
T1325 |
523-527 |
NN |
denotes |
VEGF |
T1326 |
527-528 |
-RRB- |
denotes |
) |
T1327 |
536-537 |
-LRB- |
denotes |
( |
T1328 |
537-539 |
CD |
denotes |
20 |
T1329 |
539-540 |
-RRB- |
denotes |
) |
T1330 |
540-542 |
, |
denotes |
, |
T1331 |
542-545 |
CC |
denotes |
and |
T1332 |
546-549 |
VBZ |
denotes |
has |
T1333 |
564-571 |
VBN |
denotes |
invoked |
T1334 |
550-558 |
RB |
denotes |
recently |
T1335 |
559-563 |
VBN |
denotes |
been |
T1336 |
572-574 |
IN |
denotes |
in |
T1337 |
575-580 |
NN |
denotes |
tumor |
T1338 |
581-592 |
NN |
denotes |
development |
T1339 |
593-594 |
-LRB- |
denotes |
( |
T1340 |
597-599 |
CD |
denotes |
22 |
T1341 |
594-596 |
CD |
denotes |
21 |
T1342 |
596-597 |
, |
denotes |
, |
T1343 |
599-600 |
-RRB- |
denotes |
) |
T1344 |
600-601 |
. |
denotes |
. |
T1345 |
601-787 |
sentence |
denotes |
Furthermore, MTF-1 has an essential function during embryogenesis: targeted disruption of Mtf1 results in embryonic lethality around 14 days post coitum due to hepatocyte necrosis (23). |
T1346 |
602-613 |
RB |
denotes |
Furthermore |
T1347 |
621-624 |
VBZ |
denotes |
has |
T1348 |
613-615 |
, |
denotes |
, |
T1349 |
615-618 |
NN |
denotes |
MTF |
T1350 |
618-619 |
HYPH |
denotes |
- |
T1351 |
619-620 |
CD |
denotes |
1 |
T1352 |
697-704 |
VBZ |
denotes |
results |
T1353 |
625-627 |
DT |
denotes |
an |
T1354 |
638-646 |
NN |
denotes |
function |
T1355 |
628-637 |
JJ |
denotes |
essential |
T1356 |
647-653 |
IN |
denotes |
during |
T1357 |
654-667 |
NN |
denotes |
embryogenesis |
T1358 |
667-669 |
: |
denotes |
: |
T1359 |
669-677 |
VBN |
denotes |
targeted |
T1360 |
678-688 |
NN |
denotes |
disruption |
T1361 |
689-691 |
IN |
denotes |
of |
T1362 |
692-696 |
NN |
denotes |
Mtf1 |
T1363 |
705-707 |
IN |
denotes |
in |
T1364 |
708-717 |
JJ |
denotes |
embryonic |
T1365 |
718-727 |
NN |
denotes |
lethality |
T1366 |
728-734 |
IN |
denotes |
around |
T1367 |
735-737 |
CD |
denotes |
14 |
T1368 |
738-742 |
NNS |
denotes |
days |
T1369 |
743-747 |
FW |
denotes |
post |
T1370 |
748-754 |
FW |
denotes |
coitum |
T1371 |
755-758 |
IN |
denotes |
due |
T1372 |
759-761 |
IN |
denotes |
to |
T1373 |
762-772 |
NN |
denotes |
hepatocyte |
T1374 |
773-781 |
NN |
denotes |
necrosis |
T1375 |
782-783 |
-LRB- |
denotes |
( |
T1376 |
783-785 |
CD |
denotes |
23 |
T1377 |
785-786 |
-RRB- |
denotes |
) |
T1378 |
786-787 |
. |
denotes |
. |
T1379 |
787-1029 |
sentence |
denotes |
In contrast, mice with null mutations for the stress-inducible metallothionein genes (Mt1 and Mt2) are viable, though sensitive to cadmium (24,25), indicating that additional important MTF-1 target genes are involved in the lethal phenotype. |
T1380 |
788-790 |
IN |
denotes |
In |
T1381 |
887-890 |
VBP |
denotes |
are |
T1382 |
791-799 |
NN |
denotes |
contrast |
T1383 |
799-801 |
, |
denotes |
, |
T1384 |
801-805 |
NNS |
denotes |
mice |
T1385 |
806-810 |
IN |
denotes |
with |
T1386 |
811-815 |
JJ |
denotes |
null |
T1387 |
816-825 |
NNS |
denotes |
mutations |
T1388 |
826-829 |
IN |
denotes |
for |
T1389 |
830-833 |
DT |
denotes |
the |
T1390 |
867-872 |
NNS |
denotes |
genes |
T1391 |
834-840 |
NN |
denotes |
stress |
T1392 |
841-850 |
JJ |
denotes |
inducible |
T1393 |
840-841 |
HYPH |
denotes |
- |
T1394 |
851-866 |
NN |
denotes |
metallothionein |
T1395 |
873-874 |
-LRB- |
denotes |
( |
T1396 |
874-877 |
NN |
denotes |
Mt1 |
T1397 |
878-881 |
CC |
denotes |
and |
T1398 |
882-885 |
NN |
denotes |
Mt2 |
T1399 |
885-886 |
-RRB- |
denotes |
) |
T1400 |
891-897 |
JJ |
denotes |
viable |
T1401 |
897-899 |
, |
denotes |
, |
T1402 |
899-905 |
IN |
denotes |
though |
T1403 |
906-915 |
JJ |
denotes |
sensitive |
T1404 |
916-918 |
IN |
denotes |
to |
T1405 |
919-926 |
NN |
denotes |
cadmium |
T1406 |
927-928 |
-LRB- |
denotes |
( |
T1407 |
931-933 |
CD |
denotes |
25 |
T1408 |
928-930 |
CD |
denotes |
24 |
T1409 |
930-931 |
, |
denotes |
, |
T1410 |
933-934 |
-RRB- |
denotes |
) |
T1411 |
934-936 |
, |
denotes |
, |
T1412 |
936-946 |
VBG |
denotes |
indicating |
T1413 |
947-951 |
IN |
denotes |
that |
T1414 |
996-1004 |
VBN |
denotes |
involved |
T1415 |
952-962 |
JJ |
denotes |
additional |
T1416 |
986-991 |
NNS |
denotes |
genes |
T1417 |
963-972 |
JJ |
denotes |
important |
T1418 |
973-976 |
NN |
denotes |
MTF |
T1419 |
976-977 |
HYPH |
denotes |
- |
T1420 |
977-978 |
CD |
denotes |
1 |
T1421 |
979-985 |
NN |
denotes |
target |
T1422 |
992-995 |
VBP |
denotes |
are |
T1423 |
1005-1007 |
IN |
denotes |
in |
T1424 |
1008-1011 |
DT |
denotes |
the |
T1425 |
1019-1028 |
NN |
denotes |
phenotype |
T1426 |
1012-1018 |
JJ |
denotes |
lethal |
T1427 |
1028-1029 |
. |
denotes |
. |
T1428 |
1029-1175 |
sentence |
denotes |
With the Cre-loxP conditional knockout technique, it is possible to circumvent the embryonic lethal phenotype of conventional Mtf1 knockout mice. |
T1429 |
1030-1034 |
IN |
denotes |
With |
T1430 |
1083-1085 |
VBZ |
denotes |
is |
T1431 |
1035-1038 |
DT |
denotes |
the |
T1432 |
1069-1078 |
NN |
denotes |
technique |
T1433 |
1039-1042 |
NN |
denotes |
Cre |
T1434 |
1043-1047 |
NN |
denotes |
loxP |
T1435 |
1042-1043 |
HYPH |
denotes |
- |
T1436 |
1048-1059 |
JJ |
denotes |
conditional |
T1437 |
1060-1068 |
NN |
denotes |
knockout |
T1438 |
1078-1080 |
, |
denotes |
, |
T1439 |
1080-1082 |
PRP |
denotes |
it |
T1440 |
1086-1094 |
JJ |
denotes |
possible |
T1441 |
1095-1097 |
TO |
denotes |
to |
T1442 |
1098-1108 |
VB |
denotes |
circumvent |
T1443 |
1109-1112 |
DT |
denotes |
the |
T1444 |
1130-1139 |
NN |
denotes |
phenotype |
T1445 |
1113-1122 |
JJ |
denotes |
embryonic |
T1446 |
1123-1129 |
JJ |
denotes |
lethal |
T1447 |
1140-1142 |
IN |
denotes |
of |
T1448 |
1143-1155 |
JJ |
denotes |
conventional |
T1449 |
1170-1174 |
NNS |
denotes |
mice |
T1450 |
1156-1160 |
NN |
denotes |
Mtf1 |
T1451 |
1161-1169 |
NN |
denotes |
knockout |
T1452 |
1174-1175 |
. |
denotes |
. |
T1453 |
1175-1328 |
sentence |
denotes |
Previous experiments with this technique revealed that deletion of Mtf1 from the liver after birth is no longer lethal under non-stress conditions (26). |
T1454 |
1176-1184 |
JJ |
denotes |
Previous |
T1455 |
1185-1196 |
NNS |
denotes |
experiments |
T1456 |
1217-1225 |
VBD |
denotes |
revealed |
T1457 |
1197-1201 |
IN |
denotes |
with |
T1458 |
1202-1206 |
DT |
denotes |
this |
T1459 |
1207-1216 |
NN |
denotes |
technique |
T1460 |
1226-1230 |
IN |
denotes |
that |
T1461 |
1275-1277 |
VBZ |
denotes |
is |
T1462 |
1231-1239 |
NN |
denotes |
deletion |
T1463 |
1240-1242 |
IN |
denotes |
of |
T1464 |
1243-1247 |
NN |
denotes |
Mtf1 |
T1465 |
1248-1252 |
IN |
denotes |
from |
T1466 |
1253-1256 |
DT |
denotes |
the |
T1467 |
1257-1262 |
NN |
denotes |
liver |
T1468 |
1263-1268 |
IN |
denotes |
after |
T1469 |
1269-1274 |
NN |
denotes |
birth |
T1470 |
1278-1280 |
RB |
denotes |
no |
T1471 |
1281-1287 |
RB |
denotes |
longer |
T1472 |
1288-1294 |
JJ |
denotes |
lethal |
T1473 |
1295-1300 |
IN |
denotes |
under |
T1474 |
1301-1311 |
JJ |
denotes |
non-stress |
T1475 |
1312-1322 |
NNS |
denotes |
conditions |
T1476 |
1323-1324 |
-LRB- |
denotes |
( |
T1477 |
1324-1326 |
CD |
denotes |
26 |
T1478 |
1326-1327 |
-RRB- |
denotes |
) |
T1479 |
1327-1328 |
. |
denotes |
. |
R558 |
T1215 |
T1216 |
det |
The,role |
R559 |
T1216 |
T1217 |
nsubjpass |
role,studied |
R560 |
T1218 |
T1216 |
prep |
of,role |
R561 |
T1219 |
T1218 |
pobj |
MTF,of |
R562 |
T1220 |
T1219 |
punct |
-,MTF |
R563 |
T1221 |
T1219 |
nummod |
1,MTF |
R564 |
T1222 |
T1217 |
aux |
has,studied |
R565 |
T1223 |
T1217 |
auxpass |
been,studied |
R566 |
T1224 |
T1225 |
advmod |
most,extensively |
R567 |
T1225 |
T1217 |
advmod |
extensively,studied |
R568 |
T1226 |
T1217 |
prep |
in,studied |
R569 |
T1227 |
T1228 |
det |
the,mouse |
R570 |
T1228 |
T1226 |
pobj |
mouse,in |
R571 |
T1229 |
T1217 |
punct |
.,studied |
R572 |
T1231 |
T1232 |
prep |
Besides,mediate |
R573 |
T1233 |
T1231 |
pcomp |
coping,Besides |
R574 |
T1234 |
T1233 |
prep |
with,coping |
R575 |
T1235 |
T1236 |
amod |
heavy,metal |
R576 |
T1236 |
T1237 |
compound |
metal,load |
R577 |
T1237 |
T1234 |
pobj |
load,with |
R578 |
T1238 |
T1232 |
punct |
", ",mediate |
R579 |
T1239 |
T1232 |
nsubj |
MTF,mediate |
R580 |
T1240 |
T1239 |
punct |
-,MTF |
R581 |
T1241 |
T1239 |
nummod |
1,MTF |
R582 |
T1242 |
T1232 |
aux |
can,mediate |
R583 |
T1243 |
T1232 |
advmod |
also,mediate |
R584 |
T1244 |
T1245 |
det |
the,induction |
R585 |
T1245 |
T1232 |
dobj |
induction,mediate |
R586 |
T1246 |
T1245 |
prep |
of,induction |
R587 |
T1247 |
T1248 |
compound |
Mt,genes |
R588 |
T1248 |
T1246 |
pobj |
genes,of |
R589 |
T1249 |
T1232 |
prep |
in,mediate |
R590 |
T1250 |
T1249 |
pobj |
response,in |
R591 |
T1251 |
T1250 |
prep |
to,response |
R592 |
T1252 |
T1253 |
amod |
other,situations |
R593 |
T1253 |
T1251 |
pobj |
situations,to |
R594 |
T1254 |
T1253 |
compound |
stress,situations |
R595 |
T1255 |
T1253 |
punct |
", ",situations |
R596 |
T1256 |
T1257 |
amod |
such,as |
R597 |
T1257 |
T1253 |
prep |
as,situations |
R598 |
T1258 |
T1259 |
amod |
oxidative,stress |
R599 |
T1259 |
T1257 |
pobj |
stress,as |
R600 |
T1260 |
T1261 |
punct |
(,17 |
R601 |
T1261 |
T1259 |
parataxis |
17,stress |
R602 |
T1262 |
T1261 |
nummod |
5,17 |
R603 |
T1263 |
T1261 |
punct |
",",17 |
R604 |
T1264 |
T1261 |
punct |
),17 |
R605 |
T1265 |
T1259 |
cc |
and,stress |
R606 |
T1266 |
T1259 |
conj |
hypoxia,stress |
R607 |
T1267 |
T1268 |
punct |
(,18 |
R608 |
T1268 |
T1266 |
parataxis |
18,hypoxia |
R609 |
T1269 |
T1268 |
punct |
),18 |
R610 |
T1270 |
T1232 |
punct |
.,mediate |
R611 |
T1272 |
T1273 |
prep |
In,required |
R612 |
T1274 |
T1272 |
pobj |
addition,In |
R613 |
T1275 |
T1273 |
punct |
", ",required |
R614 |
T1276 |
T1273 |
nsubjpass |
it,required |
R615 |
T1277 |
T1273 |
auxpass |
is,required |
R616 |
T1278 |
T1273 |
prep |
for,required |
R617 |
T1279 |
T1280 |
det |
the,metalloregulation |
R618 |
T1280 |
T1278 |
pobj |
metalloregulation,for |
R619 |
T1281 |
T1280 |
prep |
of,metalloregulation |
R620 |
T1282 |
T1281 |
pobj |
Znt1,of |
R621 |
T1283 |
T1273 |
punct |
", ",required |
R622 |
T1284 |
T1273 |
advcl |
encoding,required |
R623 |
T1285 |
T1286 |
det |
the,transporter |
R624 |
T1286 |
T1284 |
dobj |
transporter,encoding |
R625 |
T1287 |
T1286 |
amod |
major,transporter |
R626 |
T1288 |
T1289 |
compound |
plasma,membrane |
R627 |
T1289 |
T1290 |
npadvmod |
membrane,localized |
R628 |
T1290 |
T1286 |
amod |
localized,transporter |
R629 |
T1291 |
T1290 |
punct |
-,localized |
R630 |
T1292 |
T1293 |
compound |
zinc,efflux |
R631 |
T1293 |
T1286 |
compound |
efflux,transporter |
R632 |
T1294 |
T1295 |
punct |
(,19 |
R633 |
T1295 |
T1286 |
parataxis |
19,transporter |
R634 |
T1296 |
T1295 |
punct |
),19 |
R635 |
T1297 |
T1286 |
punct |
", ",transporter |
R636 |
T1298 |
T1299 |
det |
the,induction |
R637 |
T1299 |
T1286 |
appos |
induction,transporter |
R638 |
T1300 |
T1301 |
amod |
hypoxic,anoxic |
R639 |
T1301 |
T1299 |
amod |
anoxic,induction |
R640 |
T1302 |
T1301 |
punct |
/,anoxic |
R641 |
T1303 |
T1299 |
prep |
of,induction |
R642 |
T1304 |
T1305 |
det |
the,gene |
R643 |
T1305 |
T1303 |
pobj |
gene,of |
R644 |
T1306 |
T1305 |
prep |
for,gene |
R645 |
T1307 |
T1308 |
amod |
placental,factor |
R646 |
T1308 |
T1306 |
pobj |
factor,for |
R647 |
T1309 |
T1308 |
compound |
growth,factor |
R648 |
T1310 |
T1305 |
punct |
(,gene |
R649 |
T1311 |
T1305 |
appos |
Plgf,gene |
R650 |
T1312 |
T1286 |
punct |
),transporter |
R651 |
T1313 |
T1286 |
punct |
", ",transporter |
R652 |
T1314 |
T1315 |
det |
an,protein |
R653 |
T1315 |
T1286 |
appos |
protein,transporter |
R654 |
T1316 |
T1315 |
amod |
angiogenic,protein |
R655 |
T1317 |
T1315 |
prep |
of,protein |
R656 |
T1318 |
T1319 |
det |
the,family |
R657 |
T1319 |
T1317 |
pobj |
family,of |
R658 |
T1320 |
T1321 |
amod |
vascular,factor |
R659 |
T1321 |
T1319 |
nmod |
factor,family |
R660 |
T1322 |
T1321 |
amod |
endothelial,factor |
R661 |
T1323 |
T1321 |
nmod |
growth,factor |
R662 |
T1324 |
T1321 |
punct |
(,factor |
R663 |
T1325 |
T1321 |
appos |
VEGF,factor |
R664 |
T1326 |
T1319 |
punct |
),family |
R665 |
T1327 |
T1328 |
punct |
(,20 |
R666 |
T1328 |
T1319 |
parataxis |
20,family |
R667 |
T1329 |
T1328 |
punct |
),20 |
R668 |
T1330 |
T1273 |
punct |
", ",required |
R669 |
T1331 |
T1273 |
cc |
and,required |
R670 |
T1332 |
T1333 |
aux |
has,invoked |
R671 |
T1333 |
T1273 |
conj |
invoked,required |
R672 |
T1334 |
T1333 |
advmod |
recently,invoked |
R673 |
T1335 |
T1333 |
auxpass |
been,invoked |
R674 |
T1336 |
T1333 |
prep |
in,invoked |
R675 |
T1337 |
T1338 |
compound |
tumor,development |
R676 |
T1338 |
T1336 |
pobj |
development,in |
R677 |
T1339 |
T1340 |
punct |
(,22 |
R678 |
T1340 |
T1333 |
parataxis |
22,invoked |
R679 |
T1341 |
T1340 |
nummod |
21,22 |
R680 |
T1342 |
T1340 |
punct |
",",22 |
R681 |
T1343 |
T1340 |
punct |
),22 |
R682 |
T1344 |
T1273 |
punct |
.,required |
R683 |
T1346 |
T1347 |
advmod |
Furthermore,has |
R684 |
T1347 |
T1352 |
ccomp |
has,results |
R685 |
T1348 |
T1347 |
punct |
", ",has |
R686 |
T1349 |
T1347 |
nsubj |
MTF,has |
R687 |
T1350 |
T1349 |
punct |
-,MTF |
R688 |
T1351 |
T1349 |
nummod |
1,MTF |
R689 |
T1353 |
T1354 |
det |
an,function |
R690 |
T1354 |
T1347 |
dobj |
function,has |
R691 |
T1355 |
T1354 |
amod |
essential,function |
R692 |
T1356 |
T1347 |
prep |
during,has |
R693 |
T1357 |
T1356 |
pobj |
embryogenesis,during |
R694 |
T1358 |
T1352 |
punct |
: ,results |
R695 |
T1359 |
T1360 |
amod |
targeted,disruption |
R696 |
T1360 |
T1352 |
nsubj |
disruption,results |
R697 |
T1361 |
T1360 |
prep |
of,disruption |
R698 |
T1362 |
T1361 |
pobj |
Mtf1,of |
R699 |
T1363 |
T1352 |
prep |
in,results |
R700 |
T1364 |
T1365 |
amod |
embryonic,lethality |
R701 |
T1365 |
T1363 |
pobj |
lethality,in |
R702 |
T1366 |
T1352 |
prep |
around,results |
R703 |
T1367 |
T1368 |
nummod |
14,days |
R704 |
T1368 |
T1366 |
pobj |
days,around |
R705 |
T1369 |
T1370 |
advmod |
post,coitum |
R706 |
T1370 |
T1368 |
advmod |
coitum,days |
R707 |
T1371 |
T1352 |
prep |
due,results |
R708 |
T1372 |
T1371 |
pcomp |
to,due |
R709 |
T1373 |
T1374 |
compound |
hepatocyte,necrosis |
R710 |
T1374 |
T1371 |
pobj |
necrosis,due |
R711 |
T1375 |
T1376 |
punct |
(,23 |
R712 |
T1376 |
T1352 |
parataxis |
23,results |
R713 |
T1377 |
T1376 |
punct |
),23 |
R714 |
T1378 |
T1352 |
punct |
.,results |
R715 |
T1380 |
T1381 |
prep |
In,are |
R716 |
T1382 |
T1380 |
pobj |
contrast,In |
R717 |
T1383 |
T1381 |
punct |
", ",are |
R718 |
T1384 |
T1381 |
nsubj |
mice,are |
R719 |
T1385 |
T1384 |
prep |
with,mice |
R720 |
T1386 |
T1387 |
amod |
null,mutations |
R721 |
T1387 |
T1385 |
pobj |
mutations,with |
R722 |
T1388 |
T1387 |
prep |
for,mutations |
R723 |
T1389 |
T1390 |
det |
the,genes |
R724 |
T1390 |
T1388 |
pobj |
genes,for |
R725 |
T1391 |
T1392 |
npadvmod |
stress,inducible |
R726 |
T1392 |
T1390 |
amod |
inducible,genes |
R727 |
T1393 |
T1392 |
punct |
-,inducible |
R728 |
T1394 |
T1390 |
compound |
metallothionein,genes |
R729 |
T1395 |
T1390 |
punct |
(,genes |
R730 |
T1396 |
T1390 |
appos |
Mt1,genes |
R731 |
T1397 |
T1396 |
cc |
and,Mt1 |
R732 |
T1398 |
T1396 |
conj |
Mt2,Mt1 |
R733 |
T1399 |
T1381 |
punct |
),are |
R734 |
T1400 |
T1381 |
acomp |
viable,are |
R735 |
T1401 |
T1381 |
punct |
", ",are |
R736 |
T1402 |
T1403 |
mark |
though,sensitive |
R737 |
T1403 |
T1381 |
advcl |
sensitive,are |
R738 |
T1404 |
T1403 |
prep |
to,sensitive |
R739 |
T1405 |
T1404 |
pobj |
cadmium,to |
R740 |
T1406 |
T1407 |
punct |
(,25 |
R741 |
T1407 |
T1403 |
parataxis |
25,sensitive |
R742 |
T1408 |
T1407 |
nummod |
24,25 |
R743 |
T1409 |
T1407 |
punct |
",",25 |
R744 |
T1410 |
T1407 |
punct |
),25 |
R745 |
T1411 |
T1381 |
punct |
", ",are |
R746 |
T1412 |
T1381 |
advcl |
indicating,are |
R747 |
T1413 |
T1414 |
mark |
that,involved |
R748 |
T1414 |
T1412 |
ccomp |
involved,indicating |
R749 |
T1415 |
T1416 |
amod |
additional,genes |
R750 |
T1416 |
T1414 |
nsubjpass |
genes,involved |
R751 |
T1417 |
T1416 |
amod |
important,genes |
R752 |
T1418 |
T1416 |
nmod |
MTF,genes |
R753 |
T1419 |
T1418 |
punct |
-,MTF |
R754 |
T1420 |
T1418 |
nummod |
1,MTF |
R755 |
T1421 |
T1416 |
compound |
target,genes |
R756 |
T1422 |
T1414 |
auxpass |
are,involved |
R757 |
T1423 |
T1414 |
prep |
in,involved |
R758 |
T1424 |
T1425 |
det |
the,phenotype |
R759 |
T1425 |
T1423 |
pobj |
phenotype,in |
R760 |
T1426 |
T1425 |
amod |
lethal,phenotype |
R761 |
T1427 |
T1381 |
punct |
.,are |
R762 |
T1429 |
T1430 |
prep |
With,is |
R763 |
T1431 |
T1432 |
det |
the,technique |
R764 |
T1432 |
T1429 |
pobj |
technique,With |
R765 |
T1433 |
T1434 |
nmod |
Cre,loxP |
R766 |
T1434 |
T1432 |
nmod |
loxP,technique |
R767 |
T1435 |
T1434 |
punct |
-,loxP |
R768 |
T1436 |
T1437 |
amod |
conditional,knockout |
R769 |
T1437 |
T1432 |
compound |
knockout,technique |
R770 |
T1438 |
T1430 |
punct |
", ",is |
R771 |
T1439 |
T1430 |
nsubj |
it,is |
R772 |
T1440 |
T1430 |
acomp |
possible,is |
R773 |
T1441 |
T1442 |
aux |
to,circumvent |
R774 |
T1442 |
T1430 |
xcomp |
circumvent,is |
R775 |
T1443 |
T1444 |
det |
the,phenotype |
R776 |
T1444 |
T1442 |
dobj |
phenotype,circumvent |
R777 |
T1445 |
T1446 |
amod |
embryonic,lethal |
R778 |
T1446 |
T1444 |
amod |
lethal,phenotype |
R779 |
T1447 |
T1444 |
prep |
of,phenotype |
R780 |
T1448 |
T1449 |
amod |
conventional,mice |
R781 |
T1449 |
T1447 |
pobj |
mice,of |
R782 |
T1450 |
T1451 |
compound |
Mtf1,knockout |
R783 |
T1451 |
T1449 |
compound |
knockout,mice |
R784 |
T1452 |
T1430 |
punct |
.,is |
R785 |
T1454 |
T1455 |
amod |
Previous,experiments |
R786 |
T1455 |
T1456 |
nsubj |
experiments,revealed |
R787 |
T1457 |
T1455 |
prep |
with,experiments |
R788 |
T1458 |
T1459 |
det |
this,technique |
R789 |
T1459 |
T1457 |
pobj |
technique,with |
R790 |
T1460 |
T1461 |
mark |
that,is |
R791 |
T1461 |
T1456 |
ccomp |
is,revealed |
R792 |
T1462 |
T1461 |
nsubj |
deletion,is |
R793 |
T1463 |
T1462 |
prep |
of,deletion |
R794 |
T1464 |
T1463 |
pobj |
Mtf1,of |
R795 |
T1465 |
T1462 |
prep |
from,deletion |
R796 |
T1466 |
T1467 |
det |
the,liver |
R797 |
T1467 |
T1465 |
pobj |
liver,from |
R798 |
T1468 |
T1462 |
prep |
after,deletion |
R799 |
T1469 |
T1468 |
pobj |
birth,after |
R800 |
T1470 |
T1471 |
neg |
no,longer |
R801 |
T1471 |
T1461 |
advmod |
longer,is |
R802 |
T1472 |
T1461 |
acomp |
lethal,is |
R803 |
T1473 |
T1461 |
prep |
under,is |
R804 |
T1474 |
T1475 |
amod |
non-stress,conditions |
R805 |
T1475 |
T1473 |
pobj |
conditions,under |
R806 |
T1476 |
T1477 |
punct |
(,26 |
R807 |
T1477 |
T1461 |
parataxis |
26,is |
R808 |
T1478 |
T1477 |
punct |
),26 |
R809 |
T1479 |
T1456 |
punct |
.,revealed |