PMC:1253828 / 27362-28193 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1253828","sourcedb":"PMC","sourceid":"1253828","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1253828","text":"To analyze the role of the glutathione system in the cellular cadmium response, mouse embryonic fibroblasts with and without functional Mtf1 were treated with cadmium in combination with BSO, a specific inhibitor of glutamate-cysteine ligase (31), and cell viability was assessed by a colorimetric assay based on the tetrazolium salt MTT (Figure 6). Increasing concentrations of BSO or cadmium alone were to some extent cytotoxic for the examined cell lines. Treatment with both BSO and cadmium resulted in an enhanced lethality particularly for the cells without functional Mtf1, indicating that a depletion of glutathione together with a lack of Mtf1 impair an efficient anti-cadmium defense. Thus, adequate glutathione supply as well as MTF-1 and its target genes are essential for the survival of the cell under cadmium stress.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T8416","span":{"begin":0,"end":2},"obj":"TO"},{"id":"T8417","span":{"begin":3,"end":10},"obj":"VB"},{"id":"T8418","span":{"begin":146,"end":153},"obj":"VBN"},{"id":"T8419","span":{"begin":11,"end":14},"obj":"DT"},{"id":"T8420","span":{"begin":15,"end":19},"obj":"NN"},{"id":"T8421","span":{"begin":20,"end":22},"obj":"IN"},{"id":"T8422","span":{"begin":23,"end":26},"obj":"DT"},{"id":"T8423","span":{"begin":39,"end":45},"obj":"NN"},{"id":"T8424","span":{"begin":27,"end":38},"obj":"NN"},{"id":"T8425","span":{"begin":46,"end":48},"obj":"IN"},{"id":"T8426","span":{"begin":49,"end":52},"obj":"DT"},{"id":"T8427","span":{"begin":70,"end":78},"obj":"NN"},{"id":"T8428","span":{"begin":53,"end":61},"obj":"JJ"},{"id":"T8429","span":{"begin":62,"end":69},"obj":"NN"},{"id":"T8430","span":{"begin":78,"end":80},"obj":","},{"id":"T8431","span":{"begin":80,"end":85},"obj":"NN"},{"id":"T8432","span":{"begin":96,"end":107},"obj":"NNS"},{"id":"T8433","span":{"begin":86,"end":95},"obj":"JJ"},{"id":"T8434","span":{"begin":108,"end":112},"obj":"IN"},{"id":"T8435","span":{"begin":113,"end":116},"obj":"CC"},{"id":"T8436","span":{"begin":117,"end":124},"obj":"IN"},{"id":"T8437","span":{"begin":125,"end":135},"obj":"JJ"},{"id":"T8438","span":{"begin":136,"end":140},"obj":"NN"},{"id":"T8439","span":{"begin":141,"end":145},"obj":"VBD"},{"id":"T8440","span":{"begin":154,"end":158},"obj":"IN"},{"id":"T8441","span":{"begin":159,"end":166},"obj":"NN"},{"id":"T8442","span":{"begin":167,"end":169},"obj":"IN"},{"id":"T8443","span":{"begin":170,"end":181},"obj":"NN"},{"id":"T8444","span":{"begin":182,"end":186},"obj":"IN"},{"id":"T8445","span":{"begin":187,"end":190},"obj":"NN"},{"id":"T8446","span":{"begin":190,"end":192},"obj":","},{"id":"T8447","span":{"begin":192,"end":193},"obj":"DT"},{"id":"T8448","span":{"begin":203,"end":212},"obj":"NN"},{"id":"T8449","span":{"begin":194,"end":202},"obj":"JJ"},{"id":"T8450","span":{"begin":213,"end":215},"obj":"IN"},{"id":"T8451","span":{"begin":216,"end":225},"obj":"NN"},{"id":"T8452","span":{"begin":226,"end":234},"obj":"NN"},{"id":"T8453","span":{"begin":225,"end":226},"obj":"HYPH"},{"id":"T8454","span":{"begin":235,"end":241},"obj":"NN"},{"id":"T8455","span":{"begin":242,"end":243},"obj":"-LRB-"},{"id":"T8456","span":{"begin":243,"end":245},"obj":"CD"},{"id":"T8457","span":{"begin":245,"end":246},"obj":"-RRB-"},{"id":"T8458","span":{"begin":246,"end":248},"obj":","},{"id":"T8459","span":{"begin":248,"end":251},"obj":"CC"},{"id":"T8460","span":{"begin":252,"end":256},"obj":"NN"},{"id":"T8461","span":{"begin":257,"end":266},"obj":"NN"},{"id":"T8462","span":{"begin":271,"end":279},"obj":"VBN"},{"id":"T8463","span":{"begin":267,"end":270},"obj":"VBD"},{"id":"T8464","span":{"begin":280,"end":282},"obj":"IN"},{"id":"T8465","span":{"begin":283,"end":284},"obj":"DT"},{"id":"T8466","span":{"begin":298,"end":303},"obj":"NN"},{"id":"T8467","span":{"begin":285,"end":297},"obj":"JJ"},{"id":"T8468","span":{"begin":304,"end":309},"obj":"VBN"},{"id":"T8469","span":{"begin":310,"end":312},"obj":"IN"},{"id":"T8470","span":{"begin":313,"end":316},"obj":"DT"},{"id":"T8471","span":{"begin":329,"end":333},"obj":"NN"},{"id":"T8472","span":{"begin":317,"end":328},"obj":"NN"},{"id":"T8473","span":{"begin":334,"end":337},"obj":"NN"},{"id":"T8474","span":{"begin":338,"end":339},"obj":"-LRB-"},{"id":"T8475","span":{"begin":339,"end":345},"obj":"NN"},{"id":"T8476","span":{"begin":346,"end":347},"obj":"CD"},{"id":"T8477","span":{"begin":347,"end":348},"obj":"-RRB-"},{"id":"T8478","span":{"begin":348,"end":349},"obj":"."},{"id":"T8479","span":{"begin":349,"end":458},"obj":"sentence"},{"id":"T8480","span":{"begin":350,"end":360},"obj":"VBG"},{"id":"T8481","span":{"begin":361,"end":375},"obj":"NNS"},{"id":"T8482","span":{"begin":400,"end":404},"obj":"VBD"},{"id":"T8483","span":{"begin":376,"end":378},"obj":"IN"},{"id":"T8484","span":{"begin":379,"end":382},"obj":"NN"},{"id":"T8485","span":{"begin":383,"end":385},"obj":"CC"},{"id":"T8486","span":{"begin":386,"end":393},"obj":"NN"},{"id":"T8487","span":{"begin":394,"end":399},"obj":"RB"},{"id":"T8488","span":{"begin":405,"end":407},"obj":"IN"},{"id":"T8489","span":{"begin":408,"end":412},"obj":"DT"},{"id":"T8490","span":{"begin":413,"end":419},"obj":"NN"},{"id":"T8491","span":{"begin":420,"end":429},"obj":"JJ"},{"id":"T8492","span":{"begin":430,"end":433},"obj":"IN"},{"id":"T8493","span":{"begin":434,"end":437},"obj":"DT"},{"id":"T8494","span":{"begin":452,"end":457},"obj":"NNS"},{"id":"T8495","span":{"begin":438,"end":446},"obj":"VBN"},{"id":"T8496","span":{"begin":447,"end":451},"obj":"NN"},{"id":"T8497","span":{"begin":457,"end":458},"obj":"."},{"id":"T8498","span":{"begin":458,"end":694},"obj":"sentence"},{"id":"T8499","span":{"begin":459,"end":468},"obj":"NN"},{"id":"T8500","span":{"begin":495,"end":503},"obj":"VBD"},{"id":"T8501","span":{"begin":469,"end":473},"obj":"IN"},{"id":"T8502","span":{"begin":474,"end":478},"obj":"CC"},{"id":"T8503","span":{"begin":479,"end":482},"obj":"NN"},{"id":"T8504","span":{"begin":483,"end":486},"obj":"CC"},{"id":"T8505","span":{"begin":487,"end":494},"obj":"NN"},{"id":"T8506","span":{"begin":504,"end":506},"obj":"IN"},{"id":"T8507","span":{"begin":507,"end":509},"obj":"DT"},{"id":"T8508","span":{"begin":519,"end":528},"obj":"NN"},{"id":"T8509","span":{"begin":510,"end":518},"obj":"VBN"},{"id":"T8510","span":{"begin":529,"end":541},"obj":"RB"},{"id":"T8511","span":{"begin":542,"end":545},"obj":"IN"},{"id":"T8512","span":{"begin":546,"end":549},"obj":"DT"},{"id":"T8513","span":{"begin":550,"end":555},"obj":"NNS"},{"id":"T8514","span":{"begin":556,"end":563},"obj":"IN"},{"id":"T8515","span":{"begin":564,"end":574},"obj":"JJ"},{"id":"T8516","span":{"begin":575,"end":579},"obj":"NN"},{"id":"T8517","span":{"begin":579,"end":581},"obj":","},{"id":"T8518","span":{"begin":581,"end":591},"obj":"VBG"},{"id":"T8519","span":{"begin":592,"end":596},"obj":"IN"},{"id":"T8520","span":{"begin":653,"end":659},"obj":"VBP"},{"id":"T8521","span":{"begin":597,"end":598},"obj":"DT"},{"id":"T8522","span":{"begin":599,"end":608},"obj":"NN"},{"id":"T8523","span":{"begin":609,"end":611},"obj":"IN"},{"id":"T8524","span":{"begin":612,"end":623},"obj":"NN"},{"id":"T8525","span":{"begin":624,"end":632},"obj":"RB"},{"id":"T8526","span":{"begin":633,"end":637},"obj":"IN"},{"id":"T8527","span":{"begin":638,"end":639},"obj":"DT"},{"id":"T8528","span":{"begin":640,"end":644},"obj":"NN"},{"id":"T8529","span":{"begin":645,"end":647},"obj":"IN"},{"id":"T8530","span":{"begin":648,"end":652},"obj":"NN"},{"id":"T8531","span":{"begin":660,"end":662},"obj":"DT"},{"id":"T8532","span":{"begin":686,"end":693},"obj":"NN"},{"id":"T8533","span":{"begin":663,"end":672},"obj":"JJ"},{"id":"T8534","span":{"begin":673,"end":685},"obj":"JJ"},{"id":"T8535","span":{"begin":693,"end":694},"obj":"."},{"id":"T8536","span":{"begin":694,"end":831},"obj":"sentence"},{"id":"T8537","span":{"begin":695,"end":699},"obj":"RB"},{"id":"T8538","span":{"begin":767,"end":770},"obj":"VBP"},{"id":"T8539","span":{"begin":699,"end":701},"obj":","},{"id":"T8540","span":{"begin":701,"end":709},"obj":"JJ"},{"id":"T8541","span":{"begin":722,"end":728},"obj":"NN"},{"id":"T8542","span":{"begin":710,"end":721},"obj":"NN"},{"id":"T8543","span":{"begin":729,"end":731},"obj":"RB"},{"id":"T8544","span":{"begin":737,"end":739},"obj":"IN"},{"id":"T8545","span":{"begin":732,"end":736},"obj":"RB"},{"id":"T8546","span":{"begin":740,"end":743},"obj":"NN"},{"id":"T8547","span":{"begin":743,"end":744},"obj":"HYPH"},{"id":"T8548","span":{"begin":744,"end":745},"obj":"CD"},{"id":"T8549","span":{"begin":746,"end":749},"obj":"CC"},{"id":"T8550","span":{"begin":750,"end":753},"obj":"PRP$"},{"id":"T8551","span":{"begin":761,"end":766},"obj":"NNS"},{"id":"T8552","span":{"begin":754,"end":760},"obj":"NN"},{"id":"T8553","span":{"begin":771,"end":780},"obj":"JJ"},{"id":"T8554","span":{"begin":781,"end":784},"obj":"IN"},{"id":"T8555","span":{"begin":785,"end":788},"obj":"DT"},{"id":"T8556","span":{"begin":789,"end":797},"obj":"NN"},{"id":"T8557","span":{"begin":798,"end":800},"obj":"IN"},{"id":"T8558","span":{"begin":801,"end":804},"obj":"DT"},{"id":"T8559","span":{"begin":805,"end":809},"obj":"NN"},{"id":"T8560","span":{"begin":810,"end":815},"obj":"IN"},{"id":"T8561","span":{"begin":816,"end":823},"obj":"NN"},{"id":"T8562","span":{"begin":824,"end":830},"obj":"NN"},{"id":"T8563","span":{"begin":830,"end":831},"obj":"."}],"relations":[{"id":"R5324","pred":"aux","subj":"T8416","obj":"T8417"},{"id":"R5325","pred":"advcl","subj":"T8417","obj":"T8418"},{"id":"R5326","pred":"det","subj":"T8419","obj":"T8420"},{"id":"R5327","pred":"dobj","subj":"T8420","obj":"T8417"},{"id":"R5328","pred":"prep","subj":"T8421","obj":"T8420"},{"id":"R5329","pred":"det","subj":"T8422","obj":"T8423"},{"id":"R5330","pred":"pobj","subj":"T8423","obj":"T8421"},{"id":"R5331","pred":"compound","subj":"T8424","obj":"T8423"},{"id":"R5332","pred":"prep","subj":"T8425","obj":"T8420"},{"id":"R5333","pred":"det","subj":"T8426","obj":"T8427"},{"id":"R5334","pred":"pobj","subj":"T8427","obj":"T8425"},{"id":"R5335","pred":"amod","subj":"T8428","obj":"T8427"},{"id":"R5336","pred":"compound","subj":"T8429","obj":"T8427"},{"id":"R5337","pred":"punct","subj":"T8430","obj":"T8418"},{"id":"R5338","pred":"nmod","subj":"T8431","obj":"T8432"},{"id":"R5339","pred":"nsubjpass","subj":"T8432","obj":"T8418"},{"id":"R5340","pred":"amod","subj":"T8433","obj":"T8432"},{"id":"R5341","pred":"prep","subj":"T8434","obj":"T8432"},{"id":"R5342","pred":"cc","subj":"T8435","obj":"T8434"},{"id":"R5343","pred":"conj","subj":"T8436","obj":"T8434"},{"id":"R5344","pred":"amod","subj":"T8437","obj":"T8438"},{"id":"R5345","pred":"pobj","subj":"T8438","obj":"T8436"},{"id":"R5346","pred":"auxpass","subj":"T8439","obj":"T8418"},{"id":"R5347","pred":"prep","subj":"T8440","obj":"T8418"},{"id":"R5348","pred":"pobj","subj":"T8441","obj":"T8440"},{"id":"R5349","pred":"prep","subj":"T8442","obj":"T8418"},{"id":"R5350","pred":"pobj","subj":"T8443","obj":"T8442"},{"id":"R5351","pred":"prep","subj":"T8444","obj":"T8443"},{"id":"R5352","pred":"pobj","subj":"T8445","obj":"T8444"},{"id":"R5353","pred":"punct","subj":"T8446","obj":"T8445"},{"id":"R5354","pred":"det","subj":"T8447","obj":"T8448"},{"id":"R5355","pred":"appos","subj":"T8448","obj":"T8445"},{"id":"R5356","pred":"amod","subj":"T8449","obj":"T8448"},{"id":"R5357","pred":"prep","subj":"T8450","obj":"T8448"},{"id":"R5358","pred":"compound","subj":"T8451","obj":"T8452"},{"id":"R5359","pred":"compound","subj":"T8452","obj":"T8454"},{"id":"R5360","pred":"punct","subj":"T8453","obj":"T8452"},{"id":"R5361","pred":"pobj","subj":"T8454","obj":"T8450"},{"id":"R5362","pred":"punct","subj":"T8455","obj":"T8456"},{"id":"R5363","pred":"parataxis","subj":"T8456","obj":"T8454"},{"id":"R5364","pred":"punct","subj":"T8457","obj":"T8456"},{"id":"R5365","pred":"punct","subj":"T8458","obj":"T8418"},{"id":"R5366","pred":"cc","subj":"T8459","obj":"T8418"},{"id":"R5367","pred":"compound","subj":"T8460","obj":"T8461"},{"id":"R5368","pred":"nsubjpass","subj":"T8461","obj":"T8462"},{"id":"R5369","pred":"conj","subj":"T8462","obj":"T8418"},{"id":"R5370","pred":"auxpass","subj":"T8463","obj":"T8462"},{"id":"R5371","pred":"agent","subj":"T8464","obj":"T8462"},{"id":"R5372","pred":"det","subj":"T8465","obj":"T8466"},{"id":"R5373","pred":"pobj","subj":"T8466","obj":"T8464"},{"id":"R5374","pred":"amod","subj":"T8467","obj":"T8466"},{"id":"R5375","pred":"prep","subj":"T8468","obj":"T8466"},{"id":"R5376","pred":"prep","subj":"T8469","obj":"T8468"},{"id":"R5377","pred":"det","subj":"T8470","obj":"T8471"},{"id":"R5378","pred":"pobj","subj":"T8471","obj":"T8469"},{"id":"R5379","pred":"compound","subj":"T8472","obj":"T8471"},{"id":"R5380","pred":"appos","subj":"T8473","obj":"T8471"},{"id":"R5381","pred":"punct","subj":"T8474","obj":"T8475"},{"id":"R5382","pred":"parataxis","subj":"T8475","obj":"T8462"},{"id":"R5383","pred":"nummod","subj":"T8476","obj":"T8475"},{"id":"R5384","pred":"punct","subj":"T8477","obj":"T8475"},{"id":"R5385","pred":"punct","subj":"T8478","obj":"T8462"},{"id":"R5386","pred":"amod","subj":"T8480","obj":"T8481"},{"id":"R5387","pred":"nsubj","subj":"T8481","obj":"T8482"},{"id":"R5388","pred":"prep","subj":"T8483","obj":"T8481"},{"id":"R5389","pred":"pobj","subj":"T8484","obj":"T8483"},{"id":"R5390","pred":"cc","subj":"T8485","obj":"T8484"},{"id":"R5391","pred":"conj","subj":"T8486","obj":"T8484"},{"id":"R5392","pred":"advmod","subj":"T8487","obj":"T8484"},{"id":"R5393","pred":"prep","subj":"T8488","obj":"T8482"},{"id":"R5394","pred":"det","subj":"T8489","obj":"T8490"},{"id":"R5395","pred":"pobj","subj":"T8490","obj":"T8488"},{"id":"R5396","pred":"acomp","subj":"T8491","obj":"T8482"},{"id":"R5397","pred":"prep","subj":"T8492","obj":"T8491"},{"id":"R5398","pred":"det","subj":"T8493","obj":"T8494"},{"id":"R5399","pred":"pobj","subj":"T8494","obj":"T8492"},{"id":"R5400","pred":"amod","subj":"T8495","obj":"T8494"},{"id":"R5401","pred":"compound","subj":"T8496","obj":"T8494"},{"id":"R5402","pred":"punct","subj":"T8497","obj":"T8482"},{"id":"R5403","pred":"nsubj","subj":"T8499","obj":"T8500"},{"id":"R5404","pred":"prep","subj":"T8501","obj":"T8499"},{"id":"R5405","pred":"preconj","subj":"T8502","obj":"T8503"},{"id":"R5406","pred":"pobj","subj":"T8503","obj":"T8501"},{"id":"R5407","pred":"cc","subj":"T8504","obj":"T8503"},{"id":"R5408","pred":"conj","subj":"T8505","obj":"T8503"},{"id":"R5409","pred":"prep","subj":"T8506","obj":"T8500"},{"id":"R5410","pred":"det","subj":"T8507","obj":"T8508"},{"id":"R5411","pred":"pobj","subj":"T8508","obj":"T8506"},{"id":"R5412","pred":"amod","subj":"T8509","obj":"T8508"},{"id":"R5413","pred":"advmod","subj":"T8510","obj":"T8511"},{"id":"R5414","pred":"prep","subj":"T8511","obj":"T8500"},{"id":"R5415","pred":"det","subj":"T8512","obj":"T8513"},{"id":"R5416","pred":"pobj","subj":"T8513","obj":"T8511"},{"id":"R5417","pred":"prep","subj":"T8514","obj":"T8513"},{"id":"R5418","pred":"amod","subj":"T8515","obj":"T8516"},{"id":"R5419","pred":"pobj","subj":"T8516","obj":"T8514"},{"id":"R5420","pred":"punct","subj":"T8517","obj":"T8500"},{"id":"R5421","pred":"advcl","subj":"T8518","obj":"T8500"},{"id":"R5422","pred":"mark","subj":"T8519","obj":"T8520"},{"id":"R5423","pred":"ccomp","subj":"T8520","obj":"T8518"},{"id":"R5424","pred":"det","subj":"T8521","obj":"T8522"},{"id":"R5425","pred":"nsubj","subj":"T8522","obj":"T8520"},{"id":"R5426","pred":"prep","subj":"T8523","obj":"T8522"},{"id":"R5427","pred":"pobj","subj":"T8524","obj":"T8523"},{"id":"R5428","pred":"advmod","subj":"T8525","obj":"T8522"},{"id":"R5429","pred":"prep","subj":"T8526","obj":"T8525"},{"id":"R5430","pred":"det","subj":"T8527","obj":"T8528"},{"id":"R5431","pred":"pobj","subj":"T8528","obj":"T8526"},{"id":"R5432","pred":"prep","subj":"T8529","obj":"T8528"},{"id":"R5433","pred":"pobj","subj":"T8530","obj":"T8529"},{"id":"R5434","pred":"det","subj":"T8531","obj":"T8532"},{"id":"R5435","pred":"dobj","subj":"T8532","obj":"T8520"},{"id":"R5436","pred":"amod","subj":"T8533","obj":"T8532"},{"id":"R5437","pred":"amod","subj":"T8534","obj":"T8532"},{"id":"R5438","pred":"punct","subj":"T8535","obj":"T8500"},{"id":"R5439","pred":"advmod","subj":"T8537","obj":"T8538"},{"id":"R5440","pred":"punct","subj":"T8539","obj":"T8538"},{"id":"R5441","pred":"amod","subj":"T8540","obj":"T8541"},{"id":"R5442","pred":"nsubj","subj":"T8541","obj":"T8538"},{"id":"R5443","pred":"compound","subj":"T8542","obj":"T8541"},{"id":"R5444","pred":"advmod","subj":"T8543","obj":"T8544"},{"id":"R5445","pred":"cc","subj":"T8544","obj":"T8541"},{"id":"R5446","pred":"advmod","subj":"T8545","obj":"T8544"},{"id":"R5447","pred":"conj","subj":"T8546","obj":"T8541"},{"id":"R5448","pred":"punct","subj":"T8547","obj":"T8546"},{"id":"R5449","pred":"nummod","subj":"T8548","obj":"T8546"},{"id":"R5450","pred":"cc","subj":"T8549","obj":"T8541"},{"id":"R5451","pred":"poss","subj":"T8550","obj":"T8551"},{"id":"R5452","pred":"conj","subj":"T8551","obj":"T8541"},{"id":"R5453","pred":"compound","subj":"T8552","obj":"T8551"},{"id":"R5454","pred":"acomp","subj":"T8553","obj":"T8538"},{"id":"R5455","pred":"prep","subj":"T8554","obj":"T8553"},{"id":"R5456","pred":"det","subj":"T8555","obj":"T8556"},{"id":"R5457","pred":"pobj","subj":"T8556","obj":"T8554"},{"id":"R5458","pred":"prep","subj":"T8557","obj":"T8556"},{"id":"R5459","pred":"det","subj":"T8558","obj":"T8559"},{"id":"R5460","pred":"pobj","subj":"T8559","obj":"T8557"},{"id":"R5461","pred":"prep","subj":"T8560","obj":"T8556"},{"id":"R5462","pred":"compound","subj":"T8561","obj":"T8562"},{"id":"R5463","pred":"pobj","subj":"T8562","obj":"T8560"},{"id":"R5464","pred":"punct","subj":"T8563","obj":"T8538"}],"attributes":[{"subj":"T8416","pred":"source","obj":"craft-sa-dev"},{"subj":"T8417","pred":"source","obj":"craft-sa-dev"},{"subj":"T8418","pred":"source","obj":"craft-sa-dev"},{"subj":"T8419","pred":"source","obj":"craft-sa-dev"},{"subj":"T8420","pred":"source","obj":"craft-sa-dev"},{"subj":"T8421","pred":"source","obj":"craft-sa-dev"},{"subj":"T8422","pred":"source","obj":"craft-sa-dev"},{"subj":"T8423","pred":"source","obj":"craft-sa-dev"},{"subj":"T8424","pred":"source","obj":"craft-sa-dev"},{"subj":"T8425","pred":"source","obj":"craft-sa-dev"},{"subj":"T8426","pred":"source","obj":"craft-sa-dev"},{"subj":"T8427","pred":"source","obj":"craft-sa-dev"},{"subj":"T8428","pred":"source","obj":"craft-sa-dev"},{"subj":"T8429","pred":"source","obj":"craft-sa-dev"},{"subj":"T8430","pred":"source","obj":"craft-sa-dev"},{"subj":"T8431","pred":"source","obj":"craft-sa-dev"},{"subj":"T8432","pred":"source","obj":"craft-sa-dev"},{"subj":"T8433","pred":"source","obj":"craft-sa-dev"},{"subj":"T8434","pred":"source","obj":"craft-sa-dev"},{"subj":"T8435","pred":"source","obj":"craft-sa-dev"},{"subj":"T8436","pred":"source","obj":"craft-sa-dev"},{"subj":"T8437","pred":"source","obj":"craft-sa-dev"},{"subj":"T8438","pred":"source","obj":"craft-sa-dev"},{"subj":"T8439","pred":"source","obj":"craft-sa-dev"},{"subj":"T8440","pred":"source","obj":"craft-sa-dev"},{"subj":"T8441","pred":"source","obj":"craft-sa-dev"},{"subj":"T8442","pred":"source","obj":"craft-sa-dev"},{"subj":"T8443","pred":"source","obj":"craft-sa-dev"},{"subj":"T8444","pred":"source","obj":"craft-sa-dev"},{"subj":"T8445","pred":"source","obj":"craft-sa-dev"},{"subj":"T8446","pred":"source","obj":"craft-sa-dev"},{"subj":"T8447","pred":"source","obj":"craft-sa-dev"},{"subj":"T8448","pred":"source","obj":"craft-sa-dev"},{"subj":"T8449","pred":"source","obj":"craft-sa-dev"},{"subj":"T8450","pred":"source","obj":"craft-sa-dev"},{"subj":"T8451","pred":"source","obj":"craft-sa-dev"},{"subj":"T8452","pred":"source","obj":"craft-sa-dev"},{"subj":"T8453","pred":"source","obj":"craft-sa-dev"},{"subj":"T8454","pred":"source","obj":"craft-sa-dev"},{"subj":"T8455","pred":"source","obj":"craft-sa-dev"},{"subj":"T8456","pred":"source","obj":"craft-sa-dev"},{"subj":"T8457","pred":"source","obj":"craft-sa-dev"},{"subj":"T8458","pred":"source","obj":"craft-sa-dev"},{"subj":"T8459","pred":"source","obj":"craft-sa-dev"},{"subj":"T8460","pred":"source","obj":"craft-sa-dev"},{"subj":"T8461","pred":"source","obj":"craft-sa-dev"},{"subj":"T8462","pred":"source","obj":"craft-sa-dev"},{"subj":"T8463","pred":"source","obj":"craft-sa-dev"},{"subj":"T8464","pred":"source","obj":"craft-sa-dev"},{"subj":"T8465","pred":"source","obj":"craft-sa-dev"},{"subj":"T8466","pred":"source","obj":"craft-sa-dev"},{"subj":"T8467","pred":"source","obj":"craft-sa-dev"},{"subj":"T8468","pred":"source","obj":"craft-sa-dev"},{"subj":"T8469","pred":"source","obj":"craft-sa-dev"},{"subj":"T8470","pred":"source","obj":"craft-sa-dev"},{"subj":"T8471","pred":"source","obj":"craft-sa-dev"},{"subj":"T8472","pred":"source","obj":"craft-sa-dev"},{"subj":"T8473","pred":"source","obj":"craft-sa-dev"},{"subj":"T8474","pred":"source","obj":"craft-sa-dev"},{"subj":"T8475","pred":"source","obj":"craft-sa-dev"},{"subj":"T8476","pred":"source","obj":"craft-sa-dev"},{"subj":"T8477","pred":"source","obj":"craft-sa-dev"},{"subj":"T8478","pred":"source","obj":"craft-sa-dev"},{"subj":"T8479","pred":"source","obj":"craft-sa-dev"},{"subj":"T8480","pred":"source","obj":"craft-sa-dev"},{"subj":"T8481","pred":"source","obj":"craft-sa-dev"},{"subj":"T8482","pred":"source","obj":"craft-sa-dev"},{"subj":"T8483","pred":"source","obj":"craft-sa-dev"},{"subj":"T8484","pred":"source","obj":"craft-sa-dev"},{"subj":"T8485","pred":"source","obj":"craft-sa-dev"},{"subj":"T8486","pred":"source","obj":"craft-sa-dev"},{"subj":"T8487","pred":"source","obj":"craft-sa-dev"},{"subj":"T8488","pred":"source","obj":"craft-sa-dev"},{"subj":"T8489","pred":"source","obj":"craft-sa-dev"},{"subj":"T8490","pred":"source","obj":"craft-sa-dev"},{"subj":"T8491","pred":"source","obj":"craft-sa-dev"},{"subj":"T8492","pred":"source","obj":"craft-sa-dev"},{"subj":"T8493","pred":"source","obj":"craft-sa-dev"},{"subj":"T8494","pred":"source","obj":"craft-sa-dev"},{"subj":"T8495","pred":"source","obj":"craft-sa-dev"},{"subj":"T8496","pred":"source","obj":"craft-sa-dev"},{"subj":"T8497","pred":"source","obj":"craft-sa-dev"},{"subj":"T8498","pred":"source","obj":"craft-sa-dev"},{"subj":"T8499","pred":"source","obj":"craft-sa-dev"},{"subj":"T8500","pred":"source","obj":"craft-sa-dev"},{"subj":"T8501","pred":"source","obj":"craft-sa-dev"},{"subj":"T8502","pred":"source","obj":"craft-sa-dev"},{"subj":"T8503","pred":"source","obj":"craft-sa-dev"},{"subj":"T8504","pred":"source","obj":"craft-sa-dev"},{"subj":"T8505","pred":"source","obj":"craft-sa-dev"},{"subj":"T8506","pred":"source","obj":"craft-sa-dev"},{"subj":"T8507","pred":"source","obj":"craft-sa-dev"},{"subj":"T8508","pred":"source","obj":"craft-sa-dev"},{"subj":"T8509","pred":"source","obj":"craft-sa-dev"},{"subj":"T8510","pred":"source","obj":"craft-sa-dev"},{"subj":"T8511","pred":"source","obj":"craft-sa-dev"},{"subj":"T8512","pred":"source","obj":"craft-sa-dev"},{"subj":"T8513","pred":"source","obj":"craft-sa-dev"},{"subj":"T8514","pred":"source","obj":"craft-sa-dev"},{"subj":"T8515","pred":"source","obj":"craft-sa-dev"},{"subj":"T8516","pred":"source","obj":"craft-sa-dev"},{"subj":"T8517","pred":"source","obj":"craft-sa-dev"},{"subj":"T8518","pred":"source","obj":"craft-sa-dev"},{"subj":"T8519","pred":"source","obj":"craft-sa-dev"},{"subj":"T8520","pred":"source","obj":"craft-sa-dev"},{"subj":"T8521","pred":"source","obj":"craft-sa-dev"},{"subj":"T8522","pred":"source","obj":"craft-sa-dev"},{"subj":"T8523","pred":"source","obj":"craft-sa-dev"},{"subj":"T8524","pred":"source","obj":"craft-sa-dev"},{"subj":"T8525","pred":"source","obj":"craft-sa-dev"},{"subj":"T8526","pred":"source","obj":"craft-sa-dev"},{"subj":"T8527","pred":"source","obj":"craft-sa-dev"},{"subj":"T8528","pred":"source","obj":"craft-sa-dev"},{"subj":"T8529","pred":"source","obj":"craft-sa-dev"},{"subj":"T8530","pred":"source","obj":"craft-sa-dev"},{"subj":"T8531","pred":"source","obj":"craft-sa-dev"},{"subj":"T8532","pred":"source","obj":"craft-sa-dev"},{"subj":"T8533","pred":"source","obj":"craft-sa-dev"},{"subj":"T8534","pred":"source","obj":"craft-sa-dev"},{"subj":"T8535","pred":"source","obj":"craft-sa-dev"},{"subj":"T8536","pred":"source","obj":"craft-sa-dev"},{"subj":"T8537","pred":"source","obj":"craft-sa-dev"},{"subj":"T8538","pred":"source","obj":"craft-sa-dev"},{"subj":"T8539","pred":"source","obj":"craft-sa-dev"},{"subj":"T8540","pred":"source","obj":"craft-sa-dev"},{"subj":"T8541","pred":"source","obj":"craft-sa-dev"},{"subj":"T8542","pred":"source","obj":"craft-sa-dev"},{"subj":"T8543","pred":"source","obj":"craft-sa-dev"},{"subj":"T8544","pred":"source","obj":"craft-sa-dev"},{"subj":"T8545","pred":"source","obj":"craft-sa-dev"},{"subj":"T8546","pred":"source","obj":"craft-sa-dev"},{"subj":"T8547","pred":"source","obj":"craft-sa-dev"},{"subj":"T8548","pred":"source","obj":"craft-sa-dev"},{"subj":"T8549","pred":"source","obj":"craft-sa-dev"},{"subj":"T8550","pred":"source","obj":"craft-sa-dev"},{"subj":"T8551","pred":"source","obj":"craft-sa-dev"},{"subj":"T8552","pred":"source","obj":"craft-sa-dev"},{"subj":"T8553","pred":"source","obj":"craft-sa-dev"},{"subj":"T8554","pred":"source","obj":"craft-sa-dev"},{"subj":"T8555","pred":"source","obj":"craft-sa-dev"},{"subj":"T8556","pred":"source","obj":"craft-sa-dev"},{"subj":"T8557","pred":"source","obj":"craft-sa-dev"},{"subj":"T8558","pred":"source","obj":"craft-sa-dev"},{"subj":"T8559","pred":"source","obj":"craft-sa-dev"},{"subj":"T8560","pred":"source","obj":"craft-sa-dev"},{"subj":"T8561","pred":"source","obj":"craft-sa-dev"},{"subj":"T8562","pred":"source","obj":"craft-sa-dev"},{"subj":"T8563","pred":"source","obj":"craft-sa-dev"}]},{"project":"2_test","denotations":[{"id":"16221973-38242-77403441","span":{"begin":243,"end":245},"obj":"38242"}],"attributes":[{"subj":"16221973-38242-77403441","pred":"source","obj":"2_test"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T7936","span":{"begin":27,"end":38},"obj":"CHEBI:16856"},{"id":"T7937","span":{"begin":53,"end":61},"obj":"_FRAGMENT"},{"id":"T7938","span":{"begin":70,"end":78},"obj":"GO:0051716"},{"id":"T7939","span":{"begin":80,"end":85},"obj":"NCBITaxon:10088"},{"id":"T7940","span":{"begin":86,"end":95},"obj":"UBERON:0000922"},{"id":"T7941","span":{"begin":96,"end":107},"obj":"CL:0000057"},{"id":"T7942","span":{"begin":136,"end":140},"obj":"PR:000010717"},{"id":"T7943","span":{"begin":187,"end":190},"obj":"CHEBI:28714"},{"id":"T7944","span":{"begin":203,"end":241},"obj":"CHEBI:75599"},{"id":"T7945","span":{"begin":317,"end":328},"obj":"CHEBI:78021"},{"id":"T7946","span":{"begin":329,"end":333},"obj":"CHEBI:24866"},{"id":"T7947","span":{"begin":334,"end":337},"obj":"CHEBI:53233"},{"id":"T7948","span":{"begin":379,"end":382},"obj":"CHEBI:28714"},{"id":"T7949","span":{"begin":479,"end":482},"obj":"CHEBI:28714"},{"id":"T7950","span":{"begin":575,"end":579},"obj":"PR:000010717"},{"id":"T7951","span":{"begin":612,"end":623},"obj":"CHEBI:16856"},{"id":"T7952","span":{"begin":648,"end":652},"obj":"PR:000010717"},{"id":"T7953","span":{"begin":686,"end":693},"obj":"GO:0006952"},{"id":"T7954","span":{"begin":710,"end":721},"obj":"CHEBI:16856"},{"id":"T7955","span":{"begin":740,"end":745},"obj":"PR:000010717"},{"id":"T7956","span":{"begin":761,"end":766},"obj":"SO:0000704"}],"relations":[{"id":"R5030","pred":"_lexicallyChainedTo","subj":"T7938","obj":"T7937"}],"attributes":[{"subj":"T7936","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7937","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7938","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7939","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7940","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7941","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7942","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7943","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7944","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7945","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7946","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7947","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7948","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7949","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7950","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7951","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7952","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7953","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7954","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7955","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T7956","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T8046","span":{"begin":27,"end":38},"obj":"CHEBI:16856"},{"id":"T8047","span":{"begin":53,"end":61},"obj":"CL_GO_EXT:cell"},{"id":"T8048","span":{"begin":53,"end":61},"obj":"_FRAGMENT"},{"id":"T8049","span":{"begin":70,"end":78},"obj":"GO:0051716"},{"id":"T8050","span":{"begin":62,"end":69},"obj":"CHEBI_EXT:cadmium"},{"id":"T8051","span":{"begin":80,"end":85},"obj":"NCBITaxon:10088"},{"id":"T8052","span":{"begin":86,"end":95},"obj":"UBERON:0000922"},{"id":"T8053","span":{"begin":96,"end":107},"obj":"CL:0000057"},{"id":"T8054","span":{"begin":136,"end":140},"obj":"PR_EXT:000010717"},{"id":"T8055","span":{"begin":159,"end":166},"obj":"CHEBI_EXT:cadmium"},{"id":"T8056","span":{"begin":187,"end":190},"obj":"CHEBI:28714"},{"id":"T8057","span":{"begin":203,"end":215},"obj":"_FRAGMENT"},{"id":"T8058","span":{"begin":235,"end":241},"obj":"CHEBI_GO_EXT:ligase_inhibitor"},{"id":"T8059","span":{"begin":203,"end":241},"obj":"CHEBI_EXT:75599"},{"id":"T8060","span":{"begin":216,"end":241},"obj":"GO_EXT:0004357"},{"id":"T8061","span":{"begin":226,"end":234},"obj":"CHEBI_SO_EXT:cysteine"},{"id":"T8062","span":{"begin":252,"end":256},"obj":"CL_GO_EXT:cell"},{"id":"T8063","span":{"begin":317,"end":328},"obj":"CHEBI:78021"},{"id":"T8064","span":{"begin":329,"end":333},"obj":"CHEBI:24866"},{"id":"T8065","span":{"begin":334,"end":337},"obj":"CHEBI:53233"},{"id":"T8066","span":{"begin":379,"end":382},"obj":"CHEBI:28714"},{"id":"T8067","span":{"begin":386,"end":393},"obj":"CHEBI_EXT:cadmium"},{"id":"T8068","span":{"begin":447,"end":451},"obj":"CL_GO_EXT:cell"},{"id":"T8069","span":{"begin":479,"end":482},"obj":"CHEBI:28714"},{"id":"T8070","span":{"begin":487,"end":494},"obj":"CHEBI_EXT:cadmium"},{"id":"T8071","span":{"begin":519,"end":528},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T8072","span":{"begin":550,"end":555},"obj":"CL_GO_EXT:cell"},{"id":"T8073","span":{"begin":575,"end":579},"obj":"PR_EXT:000010717"},{"id":"T8074","span":{"begin":612,"end":623},"obj":"CHEBI:16856"},{"id":"T8075","span":{"begin":648,"end":652},"obj":"PR_EXT:000010717"},{"id":"T8076","span":{"begin":678,"end":685},"obj":"CHEBI_EXT:cadmium"},{"id":"T8077","span":{"begin":686,"end":693},"obj":"GO:0006952"},{"id":"T8078","span":{"begin":710,"end":721},"obj":"CHEBI:16856"},{"id":"T8079","span":{"begin":740,"end":745},"obj":"PR_EXT:000010717"},{"id":"T8080","span":{"begin":761,"end":766},"obj":"SO_EXT:0000704"},{"id":"T8081","span":{"begin":805,"end":809},"obj":"CL_GO_EXT:cell"},{"id":"T8082","span":{"begin":816,"end":823},"obj":"CHEBI_EXT:cadmium"}],"relations":[{"id":"R5032","pred":"_lexicallyChainedTo","subj":"T8049","obj":"T8048"},{"id":"R5033","pred":"_lexicallyChainedTo","subj":"T8058","obj":"T8057"}],"attributes":[{"subj":"T8046","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8047","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8048","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8049","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8050","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8051","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8052","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8053","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8054","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8055","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8056","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8057","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8058","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8059","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8060","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8061","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8062","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8063","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8064","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8065","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8066","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8067","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8068","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8069","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8070","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8071","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8072","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8073","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8074","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8075","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8076","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8077","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8078","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8079","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8080","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8081","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8082","pred":"source","obj":"craft-ca-core-ex-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#93ecad","default":true},{"id":"2_test","color":"#ec9393"},{"id":"craft-ca-core-dev","color":"#93adec"},{"id":"craft-ca-core-ex-dev","color":"#c7ec93"}]}]}}