PMC:1253828 / 0-508 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T240","span":{"begin":10,"end":18},"obj":"NNS"},{"id":"T241","span":{"begin":0,"end":95},"obj":"sentence"},{"id":"T242","span":{"begin":4,"end":9},"obj":"JJ"},{"id":"T243","span":{"begin":19,"end":21},"obj":"IN"},{"id":"T244","span":{"begin":22,"end":34},"obj":"JJ"},{"id":"T245","span":{"begin":35,"end":42},"obj":"NN"},{"id":"T246","span":{"begin":43,"end":45},"obj":"IN"},{"id":"T247","span":{"begin":46,"end":49},"obj":"DT"},{"id":"T248","span":{"begin":50,"end":55},"obj":"NN"},{"id":"T249","span":{"begin":55,"end":57},"obj":":"},{"id":"T250","span":{"begin":57,"end":60},"obj":"NN"},{"id":"T251","span":{"begin":63,"end":79},"obj":"NNS"},{"id":"T252","span":{"begin":60,"end":61},"obj":"HYPH"},{"id":"T253","span":{"begin":61,"end":62},"obj":"CD"},{"id":"T254","span":{"begin":62,"end":63},"obj":"HYPH"},{"id":"T255","span":{"begin":80,"end":83},"obj":"CC"},{"id":"T256","span":{"begin":84,"end":95},"obj":"NN"},{"id":"T257","span":{"begin":95,"end":96},"obj":"sentence"},{"id":"T258","span":{"begin":106,"end":353},"obj":"sentence"},{"id":"T259","span":{"begin":106,"end":111},"obj":"NN"},{"id":"T260","span":{"begin":112,"end":122},"obj":"JJ"},{"id":"T261","span":{"begin":111,"end":112},"obj":"HYPH"},{"id":"T262","span":{"begin":137,"end":143},"obj":"NN"},{"id":"T263","span":{"begin":123,"end":136},"obj":"NN"},{"id":"T264","span":{"begin":154,"end":163},"obj":"VBZ"},{"id":"T265","span":{"begin":144,"end":145},"obj":"CD"},{"id":"T266","span":{"begin":146,"end":147},"obj":"-LRB-"},{"id":"T267","span":{"begin":147,"end":150},"obj":"NN"},{"id":"T268","span":{"begin":150,"end":151},"obj":"HYPH"},{"id":"T269","span":{"begin":151,"end":152},"obj":"CD"},{"id":"T270","span":{"begin":152,"end":153},"obj":"-RRB-"},{"id":"T271","span":{"begin":164,"end":174},"obj":"NN"},{"id":"T272","span":{"begin":175,"end":177},"obj":"IN"},{"id":"T273","span":{"begin":178,"end":181},"obj":"PRP$"},{"id":"T274","span":{"begin":189,"end":194},"obj":"NNS"},{"id":"T275","span":{"begin":182,"end":188},"obj":"NN"},{"id":"T276","span":{"begin":195,"end":197},"obj":"IN"},{"id":"T277","span":{"begin":198,"end":206},"obj":"NN"},{"id":"T278","span":{"begin":207,"end":209},"obj":"IN"},{"id":"T279","span":{"begin":210,"end":217},"obj":"JJ"},{"id":"T280","span":{"begin":225,"end":235},"obj":"NNS"},{"id":"T281","span":{"begin":218,"end":224},"obj":"NN"},{"id":"T282","span":{"begin":235,"end":237},"obj":","},{"id":"T283","span":{"begin":237,"end":244},"obj":"RB"},{"id":"T284","span":{"begin":257,"end":261},"obj":"NN"},{"id":"T285","span":{"begin":245,"end":250},"obj":"JJ"},{"id":"T286","span":{"begin":251,"end":256},"obj":"NN"},{"id":"T287","span":{"begin":261,"end":263},"obj":","},{"id":"T288","span":{"begin":263,"end":266},"obj":"IN"},{"id":"T289","span":{"begin":267,"end":274},"obj":"NN"},{"id":"T290","span":{"begin":275,"end":277},"obj":"IN"},{"id":"T291","span":{"begin":278,"end":283},"obj":"NN"},{"id":"T292","span":{"begin":293,"end":301},"obj":"NNS"},{"id":"T293","span":{"begin":284,"end":292},"obj":"NN"},{"id":"T294","span":{"begin":302,"end":303},"obj":"-LRB-"},{"id":"T295","span":{"begin":303,"end":307},"obj":"NNS"},{"id":"T296","span":{"begin":307,"end":308},"obj":"-RRB-"},{"id":"T297","span":{"begin":309,"end":311},"obj":"IN"},{"id":"T298","span":{"begin":312,"end":315},"obj":"DT"},{"id":"T299","span":{"begin":345,"end":352},"obj":"NNS"},{"id":"T300","span":{"begin":316,"end":326},"obj":"JJ"},{"id":"T301","span":{"begin":327,"end":335},"obj":"NN"},{"id":"T302","span":{"begin":336,"end":344},"obj":"NN"},{"id":"T303","span":{"begin":335,"end":336},"obj":"HYPH"},{"id":"T304","span":{"begin":352,"end":353},"obj":"."},{"id":"T305","span":{"begin":353,"end":425},"obj":"sentence"},{"id":"T306","span":{"begin":354,"end":365},"obj":"RB"},{"id":"T307","span":{"begin":370,"end":376},"obj":"VBZ"},{"id":"T308","span":{"begin":365,"end":367},"obj":","},{"id":"T309","span":{"begin":367,"end":369},"obj":"PRP"},{"id":"T310","span":{"begin":377,"end":378},"obj":"DT"},{"id":"T311","span":{"begin":385,"end":393},"obj":"NN"},{"id":"T312","span":{"begin":379,"end":384},"obj":"JJ"},{"id":"T313","span":{"begin":394,"end":396},"obj":"IN"},{"id":"T314","span":{"begin":397,"end":406},"obj":"JJ"},{"id":"T315","span":{"begin":413,"end":424},"obj":"NN"},{"id":"T316","span":{"begin":407,"end":412},"obj":"NN"},{"id":"T317","span":{"begin":424,"end":425},"obj":"."},{"id":"T318","span":{"begin":425,"end":506},"obj":"sentence"},{"id":"T319","span":{"begin":426,"end":433},"obj":"RB"},{"id":"T320","span":{"begin":486,"end":488},"obj":"VBZ"},{"id":"T321","span":{"begin":433,"end":435},"obj":","},{"id":"T322","span":{"begin":435,"end":443},"obj":"VBN"},{"id":"T323","span":{"begin":444,"end":452},"obj":"NN"},{"id":"T324","span":{"begin":453,"end":455},"obj":"IN"},{"id":"T325","span":{"begin":456,"end":460},"obj":"NN"},{"id":"T326","span":{"begin":461,"end":463},"obj":"IN"},{"id":"T327","span":{"begin":464,"end":467},"obj":"DT"},{"id":"T328","span":{"begin":468,"end":473},"obj":"NN"},{"id":"T329","span":{"begin":474,"end":479},"obj":"IN"},{"id":"T330","span":{"begin":480,"end":485},"obj":"NN"},{"id":"T331","span":{"begin":489,"end":491},"obj":"RB"},{"id":"T332","span":{"begin":492,"end":498},"obj":"RB"},{"id":"T333","span":{"begin":499,"end":505},"obj":"JJ"},{"id":"T334","span":{"begin":505,"end":506},"obj":"."},{"id":"T239","span":{"begin":0,"end":3},"obj":"CD"}],"relations":[{"id":"R41","pred":"amod","subj":"T279","obj":"T280"},{"id":"R42","pred":"pobj","subj":"T280","obj":"T278"},{"id":"R7","pred":"amod","subj":"T242","obj":"T240"},{"id":"R8","pred":"prep","subj":"T243","obj":"T240"},{"id":"R9","pred":"amod","subj":"T244","obj":"T245"},{"id":"R10","pred":"pobj","subj":"T245","obj":"T243"},{"id":"R11","pred":"prep","subj":"T246","obj":"T245"},{"id":"R12","pred":"det","subj":"T247","obj":"T248"},{"id":"R13","pred":"pobj","subj":"T248","obj":"T246"},{"id":"R14","pred":"punct","subj":"T249","obj":"T240"},{"id":"R15","pred":"nmod","subj":"T250","obj":"T251"},{"id":"R16","pred":"appos","subj":"T251","obj":"T240"},{"id":"R17","pred":"punct","subj":"T252","obj":"T250"},{"id":"R18","pred":"nummod","subj":"T253","obj":"T250"},{"id":"R19","pred":"punct","subj":"T254","obj":"T251"},{"id":"R20","pred":"cc","subj":"T255","obj":"T251"},{"id":"R21","pred":"conj","subj":"T256","obj":"T251"},{"id":"R22","pred":"npadvmod","subj":"T259","obj":"T260"},{"id":"R23","pred":"amod","subj":"T260","obj":"T262"},{"id":"R24","pred":"punct","subj":"T261","obj":"T260"},{"id":"R25","pred":"nsubj","subj":"T262","obj":"T264"},{"id":"R26","pred":"compound","subj":"T263","obj":"T262"},{"id":"R27","pred":"nummod","subj":"T265","obj":"T262"},{"id":"R28","pred":"punct","subj":"T266","obj":"T262"},{"id":"R29","pred":"appos","subj":"T267","obj":"T262"},{"id":"R30","pred":"punct","subj":"T268","obj":"T267"},{"id":"R31","pred":"nummod","subj":"T269","obj":"T267"},{"id":"R32","pred":"punct","subj":"T270","obj":"T264"},{"id":"R33","pred":"dobj","subj":"T271","obj":"T264"},{"id":"R34","pred":"prep","subj":"T272","obj":"T271"},{"id":"R35","pred":"poss","subj":"T273","obj":"T274"},{"id":"R36","pred":"pobj","subj":"T274","obj":"T272"},{"id":"R37","pred":"compound","subj":"T275","obj":"T274"},{"id":"R38","pred":"prep","subj":"T276","obj":"T264"},{"id":"R39","pred":"pobj","subj":"T277","obj":"T276"},{"id":"R40","pred":"prep","subj":"T278","obj":"T277"},{"id":"R43","pred":"compound","subj":"T281","obj":"T280"},{"id":"R44","pred":"punct","subj":"T282","obj":"T280"},{"id":"R45","pred":"advmod","subj":"T283","obj":"T284"},{"id":"R46","pred":"appos","subj":"T284","obj":"T280"},{"id":"R47","pred":"amod","subj":"T285","obj":"T286"},{"id":"R48","pred":"compound","subj":"T286","obj":"T284"},{"id":"R49","pred":"punct","subj":"T287","obj":"T264"},{"id":"R50","pred":"prep","subj":"T288","obj":"T264"},{"id":"R51","pred":"pobj","subj":"T289","obj":"T288"},{"id":"R52","pred":"prep","subj":"T290","obj":"T289"},{"id":"R53","pred":"compound","subj":"T291","obj":"T292"},{"id":"R54","pred":"pobj","subj":"T292","obj":"T290"},{"id":"R55","pred":"compound","subj":"T293","obj":"T292"},{"id":"R56","pred":"punct","subj":"T294","obj":"T292"},{"id":"R57","pred":"appos","subj":"T295","obj":"T292"},{"id":"R58","pred":"punct","subj":"T296","obj":"T289"},{"id":"R59","pred":"prep","subj":"T297","obj":"T289"},{"id":"R60","pred":"det","subj":"T298","obj":"T299"},{"id":"R61","pred":"pobj","subj":"T299","obj":"T297"},{"id":"R62","pred":"amod","subj":"T300","obj":"T299"},{"id":"R63","pred":"compound","subj":"T301","obj":"T302"},{"id":"R64","pred":"compound","subj":"T302","obj":"T299"},{"id":"R65","pred":"punct","subj":"T303","obj":"T302"},{"id":"R66","pred":"punct","subj":"T304","obj":"T264"},{"id":"R67","pred":"advmod","subj":"T306","obj":"T307"},{"id":"R68","pred":"punct","subj":"T308","obj":"T307"},{"id":"R69","pred":"nsubj","subj":"T309","obj":"T307"},{"id":"R70","pred":"det","subj":"T310","obj":"T311"},{"id":"R71","pred":"dobj","subj":"T311","obj":"T307"},{"id":"R72","pred":"amod","subj":"T312","obj":"T311"},{"id":"R73","pred":"prep","subj":"T313","obj":"T307"},{"id":"R74","pred":"amod","subj":"T314","obj":"T315"},{"id":"R75","pred":"pobj","subj":"T315","obj":"T313"},{"id":"R76","pred":"compound","subj":"T316","obj":"T315"},{"id":"R77","pred":"punct","subj":"T317","obj":"T307"},{"id":"R78","pred":"advmod","subj":"T319","obj":"T320"},{"id":"R79","pred":"punct","subj":"T321","obj":"T320"},{"id":"R80","pred":"amod","subj":"T322","obj":"T323"},{"id":"R81","pred":"nsubj","subj":"T323","obj":"T320"},{"id":"R82","pred":"prep","subj":"T324","obj":"T323"},{"id":"R83","pred":"pobj","subj":"T325","obj":"T324"},{"id":"R84","pred":"prep","subj":"T326","obj":"T323"},{"id":"R85","pred":"det","subj":"T327","obj":"T328"},{"id":"R86","pred":"pobj","subj":"T328","obj":"T326"},{"id":"R87","pred":"prep","subj":"T329","obj":"T323"},{"id":"R88","pred":"pobj","subj":"T330","obj":"T329"},{"id":"R89","pred":"neg","subj":"T331","obj":"T332"},{"id":"R90","pred":"advmod","subj":"T332","obj":"T320"},{"id":"R91","pred":"acomp","subj":"T333","obj":"T320"},{"id":"R92","pred":"punct","subj":"T334","obj":"T320"},{"id":"R336","pred":"nummod","subj":"T239","obj":"T240"}],"text":"Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione\n\nAbstract\nMetal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1 in the liver after birth is no longer lethal. F"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T80","span":{"begin":35,"end":42},"obj":"GO:0006952"},{"id":"T81","span":{"begin":50,"end":55},"obj":"NCBITaxon:10088"},{"id":"T82","span":{"begin":57,"end":62},"obj":"PR:000010717"},{"id":"T83","span":{"begin":84,"end":95},"obj":"CHEBI:16856"},{"id":"T84","span":{"begin":106,"end":145},"obj":"PR:000010717"},{"id":"T85","span":{"begin":147,"end":152},"obj":"PR:000010717"},{"id":"T86","span":{"begin":154,"end":163},"obj":"GO:0065007"},{"id":"T87","span":{"begin":164,"end":174},"obj":"GO:0010467"},{"id":"T88","span":{"begin":189,"end":194},"obj":"SO:0000704"},{"id":"T89","span":{"begin":327,"end":335},"obj":"SO:0000165"},{"id":"T90","span":{"begin":336,"end":344},"obj":"SO:0000167"},{"id":"T91","span":{"begin":397,"end":406},"obj":"UBERON:0000922"},{"id":"T92","span":{"begin":397,"end":406},"obj":"_FRAGMENT"},{"id":"T93","span":{"begin":413,"end":424},"obj":"GO:0009790"},{"id":"T94","span":{"begin":407,"end":412},"obj":"UBERON:0002107"},{"id":"T95","span":{"begin":407,"end":424},"obj":"GO:0001889"},{"id":"T96","span":{"begin":456,"end":460},"obj":"PR:000010717"},{"id":"T97","span":{"begin":468,"end":473},"obj":"UBERON:0002107"},{"id":"T98","span":{"begin":480,"end":485},"obj":"GO:0007567"}],"relations":[{"id":"R1","pred":"_lexicallyChainedTo","subj":"T93","obj":"T92"}],"text":"Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione\n\nAbstract\nMetal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1 in the liver after birth is no longer lethal. F"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T140","span":{"begin":27,"end":34},"obj":"CHEBI_EXT:cadmium"},{"id":"T141","span":{"begin":35,"end":42},"obj":"GO:0006952"},{"id":"T142","span":{"begin":50,"end":55},"obj":"NCBITaxon:10088"},{"id":"T143","span":{"begin":57,"end":62},"obj":"PR_EXT:000010717"},{"id":"T144","span":{"begin":84,"end":95},"obj":"CHEBI:16856"},{"id":"T145","span":{"begin":106,"end":111},"obj":"CHEBI_EXT:metal"},{"id":"T146","span":{"begin":106,"end":145},"obj":"PR_EXT:000010717"},{"id":"T147","span":{"begin":123,"end":136},"obj":"GO_EXT:transcription"},{"id":"T148","span":{"begin":123,"end":143},"obj":"GO_EXT:transcription_factor"},{"id":"T149","span":{"begin":147,"end":152},"obj":"PR_EXT:000010717"},{"id":"T150","span":{"begin":154,"end":163},"obj":"GO:0065007"},{"id":"T151","span":{"begin":164,"end":174},"obj":"GO:0010467"},{"id":"T152","span":{"begin":189,"end":194},"obj":"SO_EXT:0000704"},{"id":"T153","span":{"begin":198,"end":206},"obj":"GO_EXT:reaction_or_response"},{"id":"T154","span":{"begin":251,"end":256},"obj":"CHEBI_EXT:metal"},{"id":"T155","span":{"begin":267,"end":274},"obj":"CHEMINF_GO_EXT:chemical_binding_or_bond_formation"},{"id":"T156","span":{"begin":278,"end":283},"obj":"CHEBI_EXT:metal"},{"id":"T157","span":{"begin":284,"end":292},"obj":"GO_EXT:reaction_or_response"},{"id":"T158","span":{"begin":327,"end":335},"obj":"SO_EXT:0000165"},{"id":"T159","span":{"begin":336,"end":344},"obj":"SO_EXT:0000167"},{"id":"T160","span":{"begin":397,"end":406},"obj":"UBERON:0000922"},{"id":"T161","span":{"begin":397,"end":406},"obj":"_FRAGMENT"},{"id":"T162","span":{"begin":413,"end":424},"obj":"GO:0009790"},{"id":"T163","span":{"begin":407,"end":412},"obj":"UBERON:0002107"},{"id":"T164","span":{"begin":407,"end":424},"obj":"GO:0001889"},{"id":"T165","span":{"begin":444,"end":452},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T166","span":{"begin":456,"end":460},"obj":"PR_EXT:000010717"},{"id":"T167","span":{"begin":468,"end":473},"obj":"UBERON:0002107"},{"id":"T168","span":{"begin":480,"end":485},"obj":"GO:0007567"},{"id":"T169","span":{"begin":499,"end":505},"obj":"GO_EXT:fatality_or_lethality"}],"relations":[{"id":"R4","pred":"_lexicallyChainedTo","subj":"T162","obj":"T161"}],"text":"Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione\n\nAbstract\nMetal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1 in the liver after birth is no longer lethal. F"}