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{"project":"craft-ca-core-dev","denotations":[{"id":"T4593","span":{"begin":1025,"end":1031},"obj":"SO:0000417"},{"id":"T4592","span":{"begin":991,"end":996},"obj":"PR:000002325"},{"id":"T4591","span":{"begin":980,"end":986},"obj":"PR:000008680"},{"id":"T4590","span":{"begin":954,"end":959},"obj":"PR:000002325"},{"id":"T4589","span":{"begin":949,"end":953},"obj":"PR:000012318"},{"id":"T4588","span":{"begin":939,"end":945},"obj":"PR:000008680"},{"id":"T4587","span":{"begin":934,"end":938},"obj":"PR:000012318"},{"id":"T4586","span":{"begin":811,"end":816},"obj":"PR:000002325"},{"id":"T4585","span":{"begin":801,"end":807},"obj":"PR:000008680"},{"id":"T4584","span":{"begin":708,"end":714},"obj":"PR:000016642"},{"id":"T4583","span":{"begin":698,"end":703},"obj":"PR:000002325"},{"id":"T4582","span":{"begin":690,"end":696},"obj":"PR:000008680"},{"id":"T4581","span":{"begin":679,"end":685},"obj":"SO:0000417"},{"id":"T4580","span":{"begin":638,"end":644},"obj":"SO:0000417"},{"id":"T4579","span":{"begin":582,"end":588},"obj":"PR:000016642"},{"id":"T4578","span":{"begin":520,"end":525},"obj":"PR:000002325"},{"id":"T4577","span":{"begin":509,"end":515},"obj":"PR:000008680"},{"id":"T4576","span":{"begin":485,"end":491},"obj":"SO:0000417"},{"id":"T4575","span":{"begin":449,"end":455},"obj":"PR:000016642"},{"id":"T4574","span":{"begin":436,"end":442},"obj":"SO:0000417"},{"id":"T4573","span":{"begin":379,"end":384},"obj":"PR:000002325"},{"id":"T4572","span":{"begin":368,"end":374},"obj":"PR:000008680"},{"id":"T4571","span":{"begin":340,"end":346},"obj":"PR:000016642"},{"id":"T4570","span":{"begin":330,"end":335},"obj":"PR:000002325"},{"id":"T4569","span":{"begin":322,"end":328},"obj":"PR:000008680"},{"id":"T4568","span":{"begin":263,"end":269},"obj":"SO:0000417"},{"id":"T4567","span":{"begin":118,"end":124},"obj":"SO:0000417"},{"id":"T4566","span":{"begin":105,"end":109},"obj":"PR:000012318"}],"text":"On the basis of secondary structure predictions and amino acid sequence conservation, we defined a novel PAX6 protein domain, which we have called the C-terminal peptide. We performed yeast two-hybrid library screens with the C-terminal peptide and the whole PST domain and we identified three novel interacting proteins, HOMER3, DNCL1 and TRIM11. In library screens, HOMER3 and DNCL1 interacted with the C-terminal peptide and the PST domain while TRIM11 interacted only with the PST domain, suggesting that HOMER3 and DNCL1 specifically interact with the C-terminal peptide while TRIM11 interacts with a more N-terminal part of the PST domain. The interactions between the PST domain and HOMER3, DNCL1 and TRIM11 were confirmed in pairwise tests. We were not able to confirm the interaction between HOMER3 or DNCL1 with the C-terminal peptide construct in pairwise tests, but we showed that the C-terminal peptide was important for PAX6/HOMER3 or PAX6/DNCL1 interaction because HOMER3 and DNCL1 did not interact with a PST domain construct lacking the C-terminal peptide."}