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Id Subject Object Predicate Lexical cue
T834 11-14 DT denotes The
T835 20-27 NN denotes protein
T836 15-19 NN denotes PAX6
T837 28-30 VBZ denotes is
T838 31-32 DT denotes a
T839 33-39 NN denotes member
T840 40-42 IN denotes of
T841 43-46 DT denotes the
T842 64-70 NN denotes family
T843 47-50 NN denotes PAX
T844 51-52 -LRB- denotes (
T845 52-58 VBN denotes paired
T846 59-62 NN denotes box
T847 58-59 HYPH denotes -
T848 62-63 -RRB- denotes )
T849 71-73 IN denotes of
T850 74-89 JJ denotes transcriptional
T851 90-100 NNS denotes regulators
T852 101-104 CC denotes and
T853 105-107 VBZ denotes is
T854 108-117 JJ denotes essential
T855 118-121 IN denotes for
T856 122-128 JJ denotes normal
T857 147-158 NN denotes development
T858 129-135 JJ denotes ocular
T859 136-139 CC denotes and
T860 140-146 JJ denotes neural
T861 159-160 -LRB- denotes [
T862 160-161 CD denotes 1
T863 161-162 -RRB- denotes ]
T864 162-163 . denotes .
T865 163-301 sentence denotes Heterozygous mutations of the human PAX6 gene cause aniridia (absence of the iris) and a range of other congenital eye malformations [2].
T866 164-176 JJ denotes Heterozygous
T867 177-186 NNS denotes mutations
T868 210-215 VBP denotes cause
T869 187-189 IN denotes of
T870 190-193 DT denotes the
T871 205-209 NN denotes gene
T872 194-199 JJ denotes human
T873 200-204 NN denotes PAX6
T874 216-224 NN denotes aniridia
T875 225-226 -LRB- denotes (
T876 226-233 NN denotes absence
T877 234-236 IN denotes of
T878 237-240 DT denotes the
T879 241-245 NN denotes iris
T880 245-246 -RRB- denotes )
T881 247-250 CC denotes and
T882 251-252 DT denotes a
T883 253-258 NN denotes range
T884 259-261 IN denotes of
T885 262-267 JJ denotes other
T886 283-296 NNS denotes malformations
T887 268-278 JJ denotes congenital
T888 279-282 NN denotes eye
T889 297-298 -LRB- denotes [
T890 298-299 CD denotes 2
T891 299-300 -RRB- denotes ]
T892 300-301 . denotes .
T893 301-418 sentence denotes Neural defects such as foveal hypoplasia and optic nerve hypoplasia are common in PAX6-associated eye disease [3-5].
T894 302-308 JJ denotes Neural
T895 309-316 NNS denotes defects
T896 370-373 VBP denotes are
T897 317-321 JJ denotes such
T898 322-324 IN denotes as
T899 325-331 JJ denotes foveal
T900 332-342 NN denotes hypoplasia
T901 343-346 CC denotes and
T902 347-352 JJ denotes optic
T903 353-358 NN denotes nerve
T904 359-369 NN denotes hypoplasia
T905 374-380 JJ denotes common
T906 381-383 IN denotes in
T907 384-388 NN denotes PAX6
T908 389-399 VBN denotes associated
T909 388-389 HYPH denotes -
T910 404-411 NN denotes disease
T911 400-403 NN denotes eye
T912 412-413 -LRB- denotes [
T913 413-414 CD denotes 3
T914 414-415 SYM denotes -
T915 415-416 CD denotes 5
T916 416-417 -RRB- denotes ]
T917 417-418 . denotes .
T918 418-622 sentence denotes Homozygous mutations in man and mouse are lethal and result in severe developmental abnormalities including anophthalmia, severe reduction of the olfactory structures and gross brain malformations [2,6].
T919 419-429 JJ denotes Homozygous
T920 430-439 NNS denotes mutations
T921 457-460 VBP denotes are
T922 440-442 IN denotes in
T923 443-446 NN denotes man
T924 447-450 CC denotes and
T925 451-456 NN denotes mouse
T926 461-467 JJ denotes lethal
T927 468-471 CC denotes and
T928 472-478 VBP denotes result
T929 479-481 IN denotes in
T930 482-488 JJ denotes severe
T931 503-516 NNS denotes abnormalities
T932 489-502 JJ denotes developmental
T933 517-526 VBG denotes including
T934 527-539 NN denotes anophthalmia
T935 539-541 , denotes ,
T936 541-547 JJ denotes severe
T937 548-557 NN denotes reduction
T938 558-560 IN denotes of
T939 561-564 DT denotes the
T940 575-585 NNS denotes structures
T941 565-574 JJ denotes olfactory
T942 586-589 CC denotes and
T943 590-595 JJ denotes gross
T944 602-615 NNS denotes malformations
T945 596-601 NN denotes brain
T946 616-617 -LRB- denotes [
T947 619-620 CD denotes 6
T948 617-618 CD denotes 2
T949 618-619 , denotes ,
T950 620-621 -RRB- denotes ]
T951 621-622 . denotes .
T952 622-940 sentence denotes The roles of PAX6 in brain development have mainly been studied in homozygous mutant mice or rats and include arealisation of the cerebral cortex [7], formation of the prosencephalon-mesencephalon boundary [8], axon guidance [8], differentiation of neurons from glia [9] and neuronal migration in the cerebellum [10].
T953 623-626 DT denotes The
T954 627-632 NNS denotes roles
T955 679-686 VBN denotes studied
T956 633-635 IN denotes of
T957 636-640 NN denotes PAX6
T958 641-643 IN denotes in
T959 644-649 NN denotes brain
T960 650-661 NN denotes development
T961 662-666 VBP denotes have
T962 667-673 RB denotes mainly
T963 674-678 VBN denotes been
T964 687-689 IN denotes in
T965 690-700 JJ denotes homozygous
T966 708-712 NNS denotes mice
T967 701-707 NN denotes mutant
T968 713-715 CC denotes or
T969 716-720 NNS denotes rats
T970 721-724 CC denotes and
T971 725-732 VBP denotes include
T972 733-745 NN denotes arealisation
T973 746-748 IN denotes of
T974 749-752 DT denotes the
T975 762-768 NN denotes cortex
T976 753-761 JJ denotes cerebral
T977 769-770 -LRB- denotes [
T978 770-771 CD denotes 7
T979 771-772 -RRB- denotes ]
T980 772-774 , denotes ,
T981 774-783 NN denotes formation
T982 784-786 IN denotes of
T983 787-790 DT denotes the
T984 820-828 NN denotes boundary
T985 791-805 NN denotes prosencephalon
T986 806-819 NN denotes mesencephalon
T987 805-806 HYPH denotes -
T988 829-830 -LRB- denotes [
T989 830-831 CD denotes 8
T990 831-832 -RRB- denotes ]
T991 832-834 , denotes ,
T992 834-838 NN denotes axon
T993 839-847 NN denotes guidance
T994 848-849 -LRB- denotes [
T995 849-850 CD denotes 8
T996 850-851 -RRB- denotes ]
T997 851-853 , denotes ,
T998 853-868 NN denotes differentiation
T999 869-871 IN denotes of
T1000 872-879 NNS denotes neurons
T1001 880-884 IN denotes from
T1002 885-889 NNS denotes glia
T1003 890-891 -LRB- denotes [
T1004 891-892 CD denotes 9
T1005 892-893 -RRB- denotes ]
T1006 894-897 CC denotes and
T1007 898-906 JJ denotes neuronal
T1008 907-916 NN denotes migration
T1009 917-919 IN denotes in
T1010 920-923 DT denotes the
T1011 924-934 NN denotes cerebellum
T1012 935-936 -LRB- denotes [
T1013 936-938 CD denotes 10
T1014 938-939 -RRB- denotes ]
T1015 939-940 . denotes .
T1016 940-1117 sentence denotes The discovery of multiple and diverse roles for PAX6 in brain development prompted MRI analyses of aniridia patients, and a range of distinctive brain anomalies were uncovered.
T1017 941-944 DT denotes The
T1018 945-954 NN denotes discovery
T1019 1015-1023 VBD denotes prompted
T1020 955-957 IN denotes of
T1021 958-966 JJ denotes multiple
T1022 979-984 NNS denotes roles
T1023 967-970 CC denotes and
T1024 971-978 JJ denotes diverse
T1025 985-988 IN denotes for
T1026 989-993 NN denotes PAX6
T1027 994-996 IN denotes in
T1028 997-1002 NN denotes brain
T1029 1003-1014 NN denotes development
T1030 1024-1027 NN denotes MRI
T1031 1028-1036 NNS denotes analyses
T1032 1037-1039 IN denotes of
T1033 1040-1048 NN denotes aniridia
T1034 1049-1057 NNS denotes patients
T1035 1057-1059 , denotes ,
T1036 1059-1062 CC denotes and
T1037 1063-1064 DT denotes a
T1038 1065-1070 NN denotes range
T1039 1107-1116 VBN denotes uncovered
T1040 1071-1073 IN denotes of
T1041 1074-1085 JJ denotes distinctive
T1042 1092-1101 NNS denotes anomalies
T1043 1086-1091 NN denotes brain
T1044 1102-1106 VBD denotes were
T1045 1116-1117 . denotes .
T1046 1117-1214 sentence denotes The most common and striking of these was absence or hypoplasia of the anterior commissure [11].
T1047 1118-1121 DT denotes The
T1048 1127-1133 JJ denotes common
T1049 1122-1126 RBS denotes most
T1050 1156-1159 VBD denotes was
T1051 1134-1137 CC denotes and
T1052 1138-1146 JJ denotes striking
T1053 1147-1149 IN denotes of
T1054 1150-1155 DT denotes these
T1055 1160-1167 NN denotes absence
T1056 1168-1170 CC denotes or
T1057 1171-1181 NN denotes hypoplasia
T1058 1182-1184 IN denotes of
T1059 1185-1188 DT denotes the
T1060 1198-1208 NN denotes commissure
T1061 1189-1197 JJ denotes anterior
T1062 1209-1210 -LRB- denotes [
T1063 1210-1212 CD denotes 11
T1064 1212-1213 -RRB- denotes ]
T1065 1213-1214 . denotes .
T1066 1214-1400 sentence denotes Other defects included absence or hypoplasia of the pineal gland, cortical polymicrogyria, white matter changes in the corpus callosum and grey matter changes in the cerebellum [11-13].
T1067 1215-1220 JJ denotes Other
T1068 1221-1228 NNS denotes defects
T1069 1229-1237 VBD denotes included
T1070 1238-1245 NN denotes absence
T1071 1246-1248 CC denotes or
T1072 1249-1259 NN denotes hypoplasia
T1073 1260-1262 IN denotes of
T1074 1263-1266 DT denotes the
T1075 1274-1279 NN denotes gland
T1076 1267-1273 JJ denotes pineal
T1077 1279-1281 , denotes ,
T1078 1281-1289 JJ denotes cortical
T1079 1290-1304 NN denotes polymicrogyria
T1080 1304-1306 , denotes ,
T1081 1306-1311 JJ denotes white
T1082 1312-1318 NN denotes matter
T1083 1319-1326 NNS denotes changes
T1084 1327-1329 IN denotes in
T1085 1330-1333 DT denotes the
T1086 1341-1349 NN denotes callosum
T1087 1334-1340 NN denotes corpus
T1088 1350-1353 CC denotes and
T1089 1354-1358 JJ denotes grey
T1090 1359-1365 NN denotes matter
T1091 1366-1373 NNS denotes changes
T1092 1374-1376 IN denotes in
T1093 1377-1380 DT denotes the
T1094 1381-1391 NN denotes cerebellum
T1095 1392-1393 -LRB- denotes [
T1096 1393-1395 CD denotes 11
T1097 1395-1396 SYM denotes -
T1098 1396-1398 CD denotes 13
T1099 1398-1399 -RRB- denotes ]
T1100 1399-1400 . denotes .
T1101 1400-1495 sentence denotes Functional changes included hyposmia and abnormal inter-hemispheric auditory transfer [11,14].
T1102 1401-1411 JJ denotes Functional
T1103 1412-1419 NNS denotes changes
T1104 1420-1428 VBD denotes included
T1105 1429-1437 NN denotes hyposmia
T1106 1438-1441 CC denotes and
T1107 1442-1450 JJ denotes abnormal
T1108 1478-1486 NN denotes transfer
T1109 1451-1468 JJ denotes inter-hemispheric
T1110 1469-1477 JJ denotes auditory
T1111 1487-1488 -LRB- denotes [
T1112 1491-1493 CD denotes 14
T1113 1488-1490 CD denotes 11
T1114 1490-1491 , denotes ,
T1115 1493-1494 -RRB- denotes ]
T1116 1494-1495 . denotes .
T1117 1495-1649 sentence denotes The defining feature of all PAX proteins is the presence of a 128 amino acid DNA-binding paired domain that has been highly conserved over evolution [1].
T1118 1496-1499 DT denotes The
T1119 1509-1516 NN denotes feature
T1120 1500-1508 VBG denotes defining
T1121 1537-1539 VBZ denotes is
T1122 1517-1519 IN denotes of
T1123 1520-1523 DT denotes all
T1124 1528-1536 NN denotes proteins
T1125 1524-1527 NN denotes PAX
T1126 1540-1543 DT denotes the
T1127 1544-1552 NN denotes presence
T1128 1553-1555 IN denotes of
T1129 1556-1557 DT denotes a
T1130 1592-1598 NN denotes domain
T1131 1558-1561 CD denotes 128
T1132 1568-1572 NN denotes acid
T1133 1562-1567 NN denotes amino
T1134 1573-1576 NN denotes DNA
T1135 1577-1584 VBG denotes binding
T1136 1576-1577 HYPH denotes -
T1137 1585-1591 JJ denotes paired
T1138 1599-1603 WDT denotes that
T1139 1620-1629 VBN denotes conserved
T1140 1604-1607 VBZ denotes has
T1141 1608-1612 VBN denotes been
T1142 1613-1619 RB denotes highly
T1143 1630-1634 IN denotes over
T1144 1635-1644 NN denotes evolution
T1145 1645-1646 -LRB- denotes [
T1146 1646-1647 CD denotes 1
T1147 1647-1648 -RRB- denotes ]
T1148 1648-1649 . denotes .
T1149 1649-1807 sentence denotes In addition to the paired domain, PAX6 also contains a DNA-binding homeodomain and a proline, serine and threonine-rich (PST) domain at the C-terminus [1,6].
T1150 1650-1652 IN denotes In
T1151 1694-1702 VBZ denotes contains
T1152 1653-1661 NN denotes addition
T1153 1662-1664 IN denotes to
T1154 1665-1668 DT denotes the
T1155 1676-1682 NN denotes domain
T1156 1669-1675 JJ denotes paired
T1157 1682-1684 , denotes ,
T1158 1684-1688 NN denotes PAX6
T1159 1689-1693 RB denotes also
T1160 1703-1704 DT denotes a
T1161 1717-1728 NN denotes homeodomain
T1162 1705-1708 NN denotes DNA
T1163 1709-1716 VBG denotes binding
T1164 1708-1709 HYPH denotes -
T1165 1729-1732 CC denotes and
T1166 1733-1734 DT denotes a
T1167 1776-1782 NN denotes domain
T1168 1735-1742 NN denotes proline
T1169 1765-1769 JJ denotes rich
T1170 1742-1744 , denotes ,
T1171 1744-1750 NN denotes serine
T1172 1751-1754 CC denotes and
T1173 1755-1764 NN denotes threonine
T1174 1764-1765 HYPH denotes -
T1175 1770-1771 -LRB- denotes (
T1176 1771-1774 NN denotes PST
T1177 1774-1775 -RRB- denotes )
T1178 1783-1785 IN denotes at
T1179 1786-1789 DT denotes the
T1180 1792-1800 NN denotes terminus
T1181 1790-1791 NN denotes C
T1182 1791-1792 HYPH denotes -
T1183 1801-1802 -LRB- denotes [
T1184 1804-1805 CD denotes 6
T1185 1802-1803 CD denotes 1
T1186 1803-1804 , denotes ,
T1187 1805-1806 -RRB- denotes ]
T1188 1806-1807 . denotes .
T1189 1807-1939 sentence denotes The PST domain, which encompasses the C-terminal 145 amino acids of PAX6, has been shown to act as a transcriptional activator [6].
T1190 1808-1811 DT denotes The
T1191 1816-1822 NN denotes domain
T1192 1812-1815 NN denotes PST
T1193 1891-1896 VBN denotes shown
T1194 1822-1824 , denotes ,
T1195 1824-1829 WDT denotes which
T1196 1830-1841 VBZ denotes encompasses
T1197 1842-1845 DT denotes the
T1198 1867-1872 NNS denotes acids
T1199 1846-1847 NN denotes C
T1200 1848-1856 JJ denotes terminal
T1201 1847-1848 HYPH denotes -
T1202 1857-1860 CD denotes 145
T1203 1861-1866 NN denotes amino
T1204 1873-1875 IN denotes of
T1205 1876-1880 NN denotes PAX6
T1206 1880-1882 , denotes ,
T1207 1882-1885 VBZ denotes has
T1208 1886-1890 VBN denotes been
T1209 1897-1899 TO denotes to
T1210 1900-1903 VB denotes act
T1211 1904-1906 IN denotes as
T1212 1907-1908 DT denotes a
T1213 1925-1934 NN denotes activator
T1214 1909-1924 JJ denotes transcriptional
T1215 1935-1936 -LRB- denotes [
T1216 1936-1937 CD denotes 6
T1217 1937-1938 -RRB- denotes ]
T1218 1938-1939 . denotes .
T1219 1939-2060 sentence denotes The PAX6 protein directly regulates a wide range of target genes [1,2] including Pax2 [15], Ngn2 [16] and glucagon [17].
T1220 1940-1943 DT denotes The
T1221 1949-1956 NN denotes protein
T1222 1944-1948 NN denotes PAX6
T1223 1966-1975 VBZ denotes regulates
T1224 1957-1965 RB denotes directly
T1225 1976-1977 DT denotes a
T1226 1983-1988 NN denotes range
T1227 1978-1982 JJ denotes wide
T1228 1989-1991 IN denotes of
T1229 1992-1998 NN denotes target
T1230 1999-2004 NNS denotes genes
T1231 2005-2006 -LRB- denotes [
T1232 2008-2009 CD denotes 2
T1233 2006-2007 CD denotes 1
T1234 2007-2008 , denotes ,
T1235 2009-2010 -RRB- denotes ]
T1236 2011-2020 VBG denotes including
T1237 2021-2025 NN denotes Pax2
T1238 2026-2027 -LRB- denotes [
T1239 2027-2029 CD denotes 15
T1240 2029-2030 -RRB- denotes ]
T1241 2030-2032 , denotes ,
T1242 2032-2036 NN denotes Ngn2
T1243 2037-2038 -LRB- denotes [
T1244 2038-2040 CD denotes 16
T1245 2040-2041 -RRB- denotes ]
T1246 2042-2045 CC denotes and
T1247 2046-2054 NN denotes glucagon
T1248 2055-2056 -LRB- denotes [
T1249 2056-2058 CD denotes 17
T1250 2058-2059 -RRB- denotes ]
T1251 2059-2060 . denotes .
T1252 2060-2199 sentence denotes The Pax6 gene has a spatially and temporally complex expression pattern in the eye, brain, nasal structures, spinal cord and pancreas [1].
T1253 2061-2064 DT denotes The
T1254 2070-2074 NN denotes gene
T1255 2065-2069 NN denotes Pax6
T1256 2075-2078 VBZ denotes has
T1257 2079-2080 DT denotes a
T1258 2125-2132 NN denotes pattern
T1259 2081-2090 RB denotes spatially
T1260 2106-2113 JJ denotes complex
T1261 2091-2094 CC denotes and
T1262 2095-2105 RB denotes temporally
T1263 2114-2124 NN denotes expression
T1264 2133-2135 IN denotes in
T1265 2136-2139 DT denotes the
T1266 2140-2143 NN denotes eye
T1267 2143-2145 , denotes ,
T1268 2145-2150 NN denotes brain
T1269 2150-2152 , denotes ,
T1270 2152-2157 JJ denotes nasal
T1271 2158-2168 NNS denotes structures
T1272 2168-2170 , denotes ,
T1273 2170-2176 JJ denotes spinal
T1274 2177-2181 NN denotes cord
T1275 2182-2185 CC denotes and
T1276 2186-2194 NN denotes pancreas
T1277 2195-2196 -LRB- denotes [
T1278 2196-2197 CD denotes 1
T1279 2197-2198 -RRB- denotes ]
T1280 2198-2199 . denotes .
T1281 2199-2348 sentence denotes Although PAX6 is clearly involved in multiple developmental processes, common themes are now emerging concerning the role of PAX6 in neural tissues.
T1282 2200-2208 IN denotes Although
T1283 2225-2233 VBN denotes involved
T1284 2209-2213 NN denotes PAX6
T1285 2214-2216 VBZ denotes is
T1286 2217-2224 RB denotes clearly
T1287 2293-2301 VBG denotes emerging
T1288 2234-2236 IN denotes in
T1289 2237-2245 JJ denotes multiple
T1290 2260-2269 NNS denotes processes
T1291 2246-2259 JJ denotes developmental
T1292 2269-2271 , denotes ,
T1293 2271-2277 JJ denotes common
T1294 2278-2284 NNS denotes themes
T1295 2285-2288 VBP denotes are
T1296 2289-2292 RB denotes now
T1297 2302-2312 VBG denotes concerning
T1298 2313-2316 DT denotes the
T1299 2317-2321 NN denotes role
T1300 2322-2324 IN denotes of
T1301 2325-2329 NN denotes PAX6
T1302 2330-2332 IN denotes in
T1303 2333-2339 JJ denotes neural
T1304 2340-2347 NNS denotes tissues
T1305 2347-2348 . denotes .
T1306 2348-2476 sentence denotes Gradients of Pax6 expression are important for determining positional characteristics in the retina [18] and the neocortex [7].
T1307 2349-2358 NNS denotes Gradients
T1308 2378-2381 VBP denotes are
T1309 2359-2361 IN denotes of
T1310 2362-2366 NN denotes Pax6
T1311 2367-2377 NN denotes expression
T1312 2382-2391 JJ denotes important
T1313 2392-2395 IN denotes for
T1314 2396-2407 VBG denotes determining
T1315 2408-2418 JJ denotes positional
T1316 2419-2434 NNS denotes characteristics
T1317 2435-2437 IN denotes in
T1318 2438-2441 DT denotes the
T1319 2442-2448 NN denotes retina
T1320 2449-2450 -LRB- denotes [
T1321 2450-2452 CD denotes 18
T1322 2452-2453 -RRB- denotes ]
T1323 2454-2457 CC denotes and
T1324 2458-2461 DT denotes the
T1325 2462-2471 NN denotes neocortex
T1326 2472-2473 -LRB- denotes [
T1327 2473-2474 CD denotes 7
T1328 2474-2475 -RRB- denotes ]
T1329 2475-2476 . denotes .
T1330 2476-2611 sentence denotes PAX6 plays a role in development of specific axonal connections between the retina and the brain [18] and within the forebrain [8,19].
T1331 2477-2481 NN denotes PAX6
T1332 2482-2487 VBZ denotes plays
T1333 2488-2489 DT denotes a
T1334 2490-2494 NN denotes role
T1335 2495-2497 IN denotes in
T1336 2498-2509 NN denotes development
T1337 2510-2512 IN denotes of
T1338 2513-2521 JJ denotes specific
T1339 2529-2540 NNS denotes connections
T1340 2522-2528 JJ denotes axonal
T1341 2541-2548 IN denotes between
T1342 2549-2552 DT denotes the
T1343 2553-2559 NN denotes retina
T1344 2560-2563 CC denotes and
T1345 2564-2567 DT denotes the
T1346 2568-2573 NN denotes brain
T1347 2574-2575 -LRB- denotes [
T1348 2575-2577 CD denotes 18
T1349 2577-2578 -RRB- denotes ]
T1350 2579-2582 CC denotes and
T1351 2583-2589 IN denotes within
T1352 2590-2593 DT denotes the
T1353 2594-2603 NN denotes forebrain
T1354 2604-2605 -LRB- denotes [
T1355 2607-2609 CD denotes 19
T1356 2605-2606 CD denotes 8
T1357 2606-2607 , denotes ,
T1358 2609-2610 -RRB- denotes ]
T1359 2610-2611 . denotes .
T1360 2611-2807 sentence denotes It is also involved in the differentiation of neural cell types from multipotent precursors in the retina [16] and the cerebral cortex [9] through activation of bHLH genes such as Ngn2 and Mash1.
T1361 2612-2614 PRP denotes It
T1362 2623-2631 VBN denotes involved
T1363 2615-2617 VBZ denotes is
T1364 2618-2622 RB denotes also
T1365 2632-2634 IN denotes in
T1366 2635-2638 DT denotes the
T1367 2639-2654 NN denotes differentiation
T1368 2655-2657 IN denotes of
T1369 2658-2664 JJ denotes neural
T1370 2670-2675 NNS denotes types
T1371 2665-2669 NN denotes cell
T1372 2676-2680 IN denotes from
T1373 2681-2692 JJ denotes multipotent
T1374 2693-2703 NNS denotes precursors
T1375 2704-2706 IN denotes in
T1376 2707-2710 DT denotes the
T1377 2711-2717 NN denotes retina
T1378 2718-2719 -LRB- denotes [
T1379 2719-2721 CD denotes 16
T1380 2721-2722 -RRB- denotes ]
T1381 2723-2726 CC denotes and
T1382 2727-2730 DT denotes the
T1383 2740-2746 NN denotes cortex
T1384 2731-2739 JJ denotes cerebral
T1385 2747-2748 -LRB- denotes [
T1386 2748-2749 CD denotes 9
T1387 2749-2750 -RRB- denotes ]
T1388 2751-2758 IN denotes through
T1389 2759-2769 NN denotes activation
T1390 2770-2772 IN denotes of
T1391 2773-2777 NN denotes bHLH
T1392 2778-2783 NNS denotes genes
T1393 2784-2788 JJ denotes such
T1394 2789-2791 IN denotes as
T1395 2792-2796 NN denotes Ngn2
T1396 2797-2800 CC denotes and
T1397 2801-2806 NN denotes Mash1
T1398 2806-2807 . denotes .
T1399 2807-2992 sentence denotes These studies provide a clear link between PAX6 function in the retina and the brain, and are of particular relevance to the neurological phenotypes of individuals with PAX6 mutations.
T1400 2808-2813 DT denotes These
T1401 2814-2821 NNS denotes studies
T1402 2822-2829 VBP denotes provide
T1403 2830-2831 DT denotes a
T1404 2838-2842 NN denotes link
T1405 2832-2837 JJ denotes clear
T1406 2843-2850 IN denotes between
T1407 2851-2855 NN denotes PAX6
T1408 2856-2864 NN denotes function
T1409 2865-2867 IN denotes in
T1410 2868-2871 DT denotes the
T1411 2872-2878 NN denotes retina
T1412 2879-2882 CC denotes and
T1413 2883-2886 DT denotes the
T1414 2887-2892 NN denotes brain
T1415 2892-2894 , denotes ,
T1416 2894-2897 CC denotes and
T1417 2898-2901 VBP denotes are
T1418 2902-2904 IN denotes of
T1419 2905-2915 JJ denotes particular
T1420 2916-2925 NN denotes relevance
T1421 2926-2928 IN denotes to
T1422 2929-2932 DT denotes the
T1423 2946-2956 NNS denotes phenotypes
T1424 2933-2945 JJ denotes neurological
T1425 2957-2959 IN denotes of
T1426 2960-2971 NNS denotes individuals
T1427 2972-2976 IN denotes with
T1428 2977-2981 NN denotes PAX6
T1429 2982-2991 NNS denotes mutations
T1430 2991-2992 . denotes .
T1431 2992-3158 sentence denotes It is becoming apparent that transcription factors do not act in isolation but are dependent on interactions with other proteins to carry out their function [20,21].
T1432 2993-2995 PRP denotes It
T1433 2999-3007 VBG denotes becoming
T1434 2996-2998 VBZ denotes is
T1435 3008-3016 JJ denotes apparent
T1436 3017-3021 IN denotes that
T1437 3051-3054 VB denotes act
T1438 3022-3035 NN denotes transcription
T1439 3036-3043 NNS denotes factors
T1440 3044-3046 VBP denotes do
T1441 3047-3050 RB denotes not
T1442 3055-3057 IN denotes in
T1443 3058-3067 NN denotes isolation
T1444 3068-3071 CC denotes but
T1445 3072-3075 VBP denotes are
T1446 3076-3085 JJ denotes dependent
T1447 3086-3088 IN denotes on
T1448 3089-3101 NNS denotes interactions
T1449 3102-3106 IN denotes with
T1450 3107-3112 JJ denotes other
T1451 3113-3121 NN denotes proteins
T1452 3122-3124 TO denotes to
T1453 3125-3130 VB denotes carry
T1454 3131-3134 RP denotes out
T1455 3135-3140 PRP$ denotes their
T1456 3141-3149 NN denotes function
T1457 3150-3151 -LRB- denotes [
T1458 3154-3156 CD denotes 21
T1459 3151-3153 CD denotes 20
T1460 3153-3154 , denotes ,
T1461 3156-3157 -RRB- denotes ]
T1462 3157-3158 . denotes .
T1463 3158-3266 sentence denotes These interactions introduce more specificity into the regulatory function of a given transcription factor.
T1464 3159-3164 DT denotes These
T1465 3165-3177 NNS denotes interactions
T1466 3178-3187 VBP denotes introduce
T1467 3188-3192 JJR denotes more
T1468 3193-3204 NN denotes specificity
T1469 3205-3209 IN denotes into
T1470 3210-3213 DT denotes the
T1471 3225-3233 NN denotes function
T1472 3214-3224 JJ denotes regulatory
T1473 3234-3236 IN denotes of
T1474 3237-3238 DT denotes a
T1475 3259-3265 NN denotes factor
T1476 3239-3244 JJ denotes given
T1477 3245-3258 NN denotes transcription
T1478 3265-3266 . denotes .
T1479 3266-3616 sentence denotes To date only three PAX6 protein-protein interactions have been described: with SOX2 on the lens-specific enhancer element of the δ-crystallin gene [22]; with MDIA, which modulates PAX6 activity in early neuronal development [23], and with MAF proteins on the glucagon promoter, which causes increased expression of this pancreatic hormone gene [17].
T1480 3267-3269 IN denotes To
T1481 3330-3339 VBN denotes described
T1482 3270-3274 NN denotes date
T1483 3275-3279 RB denotes only
T1484 3307-3319 NNS denotes interactions
T1485 3280-3285 CD denotes three
T1486 3286-3290 NN denotes PAX6
T1487 3291-3298 NN denotes protein
T1488 3299-3306 NN denotes protein
T1489 3298-3299 SYM denotes -
T1490 3320-3324 VBP denotes have
T1491 3325-3329 VBN denotes been
T1492 3339-3341 : denotes :
T1493 3341-3345 IN denotes with
T1494 3346-3350 NN denotes SOX2
T1495 3351-3353 IN denotes on
T1496 3354-3357 DT denotes the
T1497 3381-3388 NN denotes element
T1498 3358-3362 NN denotes lens
T1499 3363-3371 JJ denotes specific
T1500 3362-3363 HYPH denotes -
T1501 3372-3380 NN denotes enhancer
T1502 3389-3391 IN denotes of
T1503 3392-3395 DT denotes the
T1504 3409-3413 NN denotes gene
T1505 3396-3397 SYM denotes δ
T1506 3398-3408 NN denotes crystallin
T1507 3397-3398 HYPH denotes -
T1508 3414-3415 -LRB- denotes [
T1509 3415-3417 CD denotes 22
T1510 3417-3418 -RRB- denotes ]
T1511 3418-3419 : denotes ;
T1512 3420-3424 IN denotes with
T1513 3425-3429 NN denotes MDIA
T1514 3429-3431 , denotes ,
T1515 3431-3436 WDT denotes which
T1516 3437-3446 VBZ denotes modulates
T1517 3447-3451 NN denotes PAX6
T1518 3452-3460 NN denotes activity
T1519 3461-3463 IN denotes in
T1520 3464-3469 JJ denotes early
T1521 3479-3490 NN denotes development
T1522 3470-3478 JJ denotes neuronal
T1523 3491-3492 -LRB- denotes [
T1524 3492-3494 CD denotes 23
T1525 3494-3495 -RRB- denotes ]
T1526 3495-3497 , denotes ,
T1527 3497-3500 CC denotes and
T1528 3501-3505 IN denotes with
T1529 3506-3509 NN denotes MAF
T1530 3510-3518 NN denotes proteins
T1531 3519-3521 IN denotes on
T1532 3522-3525 DT denotes the
T1533 3535-3543 NN denotes promoter
T1534 3526-3534 NN denotes glucagon
T1535 3543-3545 , denotes ,
T1536 3545-3550 WDT denotes which
T1537 3551-3557 VBZ denotes causes
T1538 3558-3567 VBN denotes increased
T1539 3568-3578 NN denotes expression
T1540 3579-3581 IN denotes of
T1541 3582-3586 DT denotes this
T1542 3606-3610 NN denotes gene
T1543 3587-3597 JJ denotes pancreatic
T1544 3598-3605 NN denotes hormone
T1545 3611-3612 -LRB- denotes [
T1546 3612-3614 CD denotes 17
T1547 3614-3615 -RRB- denotes ]
T1548 3615-3616 . denotes .
T1549 3616-3724 sentence denotes Here we report the preliminary results of the first systematic screen for proteins that interact with PAX6.
T1550 3617-3621 RB denotes Here
T1551 3625-3631 VBP denotes report
T1552 3622-3624 PRP denotes we
T1553 3632-3635 DT denotes the
T1554 3648-3655 NNS denotes results
T1555 3636-3647 JJ denotes preliminary
T1556 3656-3658 IN denotes of
T1557 3659-3662 DT denotes the
T1558 3680-3686 NN denotes screen
T1559 3663-3668 JJ denotes first
T1560 3669-3679 JJ denotes systematic
T1561 3687-3690 IN denotes for
T1562 3691-3699 NN denotes proteins
T1563 3700-3704 WDT denotes that
T1564 3705-3713 VBP denotes interact
T1565 3714-3718 IN denotes with
T1566 3719-3723 NN denotes PAX6
T1567 3723-3724 . denotes .
T1568 3724-3890 sentence denotes We used sequence alignment algorithms and secondary structure prediction programs to define a new domain of 32 amino acids at the C-terminal end of the PAX6 protein.
T1569 3725-3727 PRP denotes We
T1570 3728-3732 VBD denotes used
T1571 3733-3741 NN denotes sequence
T1572 3742-3751 NN denotes alignment
T1573 3752-3762 NNS denotes algorithms
T1574 3763-3766 CC denotes and
T1575 3767-3776 JJ denotes secondary
T1576 3777-3786 NN denotes structure
T1577 3787-3797 NN denotes prediction
T1578 3798-3806 NNS denotes programs
T1579 3807-3809 TO denotes to
T1580 3810-3816 VB denotes define
T1581 3817-3818 DT denotes a
T1582 3823-3829 NN denotes domain
T1583 3819-3822 JJ denotes new
T1584 3830-3832 IN denotes of
T1585 3833-3835 CD denotes 32
T1586 3842-3847 NNS denotes acids
T1587 3836-3841 NN denotes amino
T1588 3848-3850 IN denotes at
T1589 3851-3854 DT denotes the
T1590 3866-3869 NN denotes end
T1591 3855-3856 NN denotes C
T1592 3857-3865 JJ denotes terminal
T1593 3856-3857 HYPH denotes -
T1594 3870-3872 IN denotes of
T1595 3873-3876 DT denotes the
T1596 3882-3889 NN denotes protein
T1597 3877-3881 NN denotes PAX6
T1598 3889-3890 . denotes .
T1599 3890-4053 sentence denotes We then screened a brain library with this peptide using the yeast two-hybrid technique and identified three novel interacting proteins, HOMER3, DNCL1 and TRIM11.
T1600 3891-3893 PRP denotes We
T1601 3899-3907 VBD denotes screened
T1602 3894-3898 RB denotes then
T1603 3908-3909 DT denotes a
T1604 3916-3923 NN denotes library
T1605 3910-3915 NN denotes brain
T1606 3924-3928 IN denotes with
T1607 3929-3933 DT denotes this
T1608 3934-3941 NN denotes peptide
T1609 3942-3947 VBG denotes using
T1610 3948-3951 DT denotes the
T1611 3969-3978 NN denotes technique
T1612 3952-3957 NN denotes yeast
T1613 3958-3961 CD denotes two
T1614 3962-3968 NN denotes hybrid
T1615 3961-3962 HYPH denotes -
T1616 3979-3982 CC denotes and
T1617 3983-3993 VBD denotes identified
T1618 3994-3999 CD denotes three
T1619 4018-4026 NN denotes proteins
T1620 4000-4005 JJ denotes novel
T1621 4006-4017 VBG denotes interacting
T1622 4026-4028 , denotes ,
T1623 4028-4034 NN denotes HOMER3
T1624 4034-4036 , denotes ,
T1625 4036-4041 NN denotes DNCL1
T1626 4042-4045 CC denotes and
T1627 4046-4052 NN denotes TRIM11
T1628 4052-4053 . denotes .
T1629 4053-4165 sentence denotes The interaction between PAX6 and these proteins was disrupted by naturally occurring C-terminal PAX6 mutations.
T1630 4054-4057 DT denotes The
T1631 4058-4069 NN denotes interaction
T1632 4106-4115 VBN denotes disrupted
T1633 4070-4077 IN denotes between
T1634 4078-4082 NN denotes PAX6
T1635 4083-4086 CC denotes and
T1636 4087-4092 DT denotes these
T1637 4093-4101 NN denotes proteins
T1638 4102-4105 VBD denotes was
T1639 4116-4118 IN denotes by
T1640 4119-4128 RB denotes naturally
T1641 4129-4138 VBG denotes occurring
T1642 4155-4164 NNS denotes mutations
T1643 4139-4140 NN denotes C
T1644 4141-4149 JJ denotes terminal
T1645 4140-4141 HYPH denotes -
T1646 4150-4154 NN denotes PAX6
T1647 4164-4165 . denotes .
R257 T834 T835 det The,protein
R258 T835 T837 nsubj protein,is
R259 T836 T835 compound PAX6,protein
R260 T838 T839 det a,member
R261 T839 T837 attr member,is
R262 T840 T839 prep of,member
R263 T841 T842 det the,family
R264 T842 T840 pobj family,of
R265 T843 T842 nmod PAX,family
R266 T844 T843 punct (,PAX
R267 T845 T846 amod paired,box
R268 T846 T843 appos box,PAX
R269 T847 T846 punct -,box
R270 T848 T842 punct ),family
R271 T849 T842 prep of,family
R272 T850 T851 amod transcriptional,regulators
R273 T851 T849 pobj regulators,of
R274 T852 T837 cc and,is
R275 T853 T837 conj is,is
R276 T854 T853 acomp essential,is
R277 T855 T854 prep for,essential
R278 T856 T857 amod normal,development
R279 T857 T855 pobj development,for
R280 T858 T857 amod ocular,development
R281 T859 T858 cc and,ocular
R282 T860 T858 conj neural,ocular
R283 T861 T862 punct [,1
R284 T862 T853 parataxis 1,is
R285 T863 T862 punct ],1
R286 T864 T837 punct .,is
R287 T866 T867 amod Heterozygous,mutations
R288 T867 T868 nsubj mutations,cause
R289 T869 T867 prep of,mutations
R290 T870 T871 det the,gene
R291 T871 T869 pobj gene,of
R292 T872 T871 amod human,gene
R293 T873 T871 compound PAX6,gene
R294 T874 T868 dobj aniridia,cause
R295 T875 T874 punct (,aniridia
R296 T876 T874 appos absence,aniridia
R297 T877 T876 prep of,absence
R298 T878 T879 det the,iris
R299 T879 T877 pobj iris,of
R300 T880 T874 punct ),aniridia
R301 T881 T874 cc and,aniridia
R302 T882 T883 det a,range
R303 T883 T874 conj range,aniridia
R304 T884 T883 prep of,range
R305 T885 T886 amod other,malformations
R306 T886 T884 pobj malformations,of
R307 T887 T886 amod congenital,malformations
R308 T888 T886 compound eye,malformations
R309 T889 T890 punct [,2
R310 T890 T868 parataxis 2,cause
R311 T891 T890 punct ],2
R312 T892 T868 punct .,cause
R313 T894 T895 amod Neural,defects
R314 T895 T896 nsubj defects,are
R315 T897 T898 amod such,as
R316 T898 T895 prep as,defects
R317 T899 T900 amod foveal,hypoplasia
R318 T900 T898 pobj hypoplasia,as
R319 T901 T900 cc and,hypoplasia
R320 T902 T903 amod optic,nerve
R321 T903 T904 compound nerve,hypoplasia
R322 T904 T900 conj hypoplasia,hypoplasia
R323 T905 T896 acomp common,are
R324 T906 T896 prep in,are
R325 T907 T908 npadvmod PAX6,associated
R326 T908 T910 amod associated,disease
R327 T909 T908 punct -,associated
R328 T910 T906 pobj disease,in
R329 T911 T910 compound eye,disease
R330 T912 T913 punct [,3
R331 T913 T896 parataxis 3,are
R332 T914 T915 punct -,5
R333 T915 T913 prep 5,3
R334 T916 T913 punct ],3
R335 T917 T896 punct .,are
R336 T919 T920 amod Homozygous,mutations
R337 T920 T921 nsubj mutations,are
R338 T922 T920 prep in,mutations
R339 T923 T922 pobj man,in
R340 T924 T923 cc and,man
R341 T925 T923 conj mouse,man
R342 T926 T921 acomp lethal,are
R343 T927 T921 cc and,are
R344 T928 T921 conj result,are
R345 T929 T928 prep in,result
R346 T930 T931 amod severe,abnormalities
R347 T931 T929 pobj abnormalities,in
R348 T932 T931 amod developmental,abnormalities
R349 T933 T931 prep including,abnormalities
R350 T934 T933 pobj anophthalmia,including
R351 T935 T934 punct ", ",anophthalmia
R352 T936 T937 amod severe,reduction
R353 T937 T934 conj reduction,anophthalmia
R354 T938 T937 prep of,reduction
R355 T939 T940 det the,structures
R356 T940 T938 pobj structures,of
R357 T941 T940 amod olfactory,structures
R358 T942 T937 cc and,reduction
R359 T943 T944 amod gross,malformations
R360 T944 T937 conj malformations,reduction
R361 T945 T944 compound brain,malformations
R362 T946 T947 punct [,6
R363 T947 T928 parataxis 6,result
R364 T948 T947 nummod 2,6
R365 T949 T947 punct ",",6
R366 T950 T947 punct ],6
R367 T951 T921 punct .,are
R368 T953 T954 det The,roles
R369 T954 T955 nsubjpass roles,studied
R370 T956 T954 prep of,roles
R371 T957 T956 pobj PAX6,of
R372 T958 T954 prep in,roles
R373 T959 T960 compound brain,development
R374 T960 T958 pobj development,in
R375 T961 T955 aux have,studied
R376 T962 T955 advmod mainly,studied
R377 T963 T955 auxpass been,studied
R378 T964 T955 prep in,studied
R379 T965 T966 amod homozygous,mice
R380 T966 T964 pobj mice,in
R381 T967 T966 compound mutant,mice
R382 T968 T966 cc or,mice
R383 T969 T966 conj rats,mice
R384 T970 T955 cc and,studied
R385 T971 T955 conj include,studied
R386 T972 T971 dobj arealisation,include
R387 T973 T972 prep of,arealisation
R388 T974 T975 det the,cortex
R389 T975 T973 pobj cortex,of
R390 T976 T975 amod cerebral,cortex
R391 T977 T978 punct [,7
R392 T978 T972 parataxis 7,arealisation
R393 T979 T978 punct ],7
R394 T980 T972 punct ", ",arealisation
R395 T981 T972 conj formation,arealisation
R396 T982 T981 prep of,formation
R397 T983 T984 det the,boundary
R398 T984 T982 pobj boundary,of
R399 T985 T986 compound prosencephalon,mesencephalon
R400 T986 T984 compound mesencephalon,boundary
R401 T987 T986 punct -,mesencephalon
R402 T988 T989 punct [,8
R403 T989 T981 parataxis 8,formation
R404 T990 T989 punct ],8
R405 T991 T981 punct ", ",formation
R406 T992 T993 compound axon,guidance
R407 T993 T981 conj guidance,formation
R408 T994 T995 punct [,8
R409 T995 T993 parataxis 8,guidance
R410 T996 T995 punct ],8
R411 T997 T993 punct ", ",guidance
R412 T998 T993 conj differentiation,guidance
R413 T999 T998 prep of,differentiation
R414 T1000 T999 pobj neurons,of
R415 T1001 T998 prep from,differentiation
R416 T1002 T1001 pobj glia,from
R417 T1003 T1004 punct [,9
R418 T1004 T998 parataxis 9,differentiation
R419 T1005 T1004 punct ],9
R420 T1006 T998 cc and,differentiation
R421 T1007 T1008 amod neuronal,migration
R422 T1008 T998 conj migration,differentiation
R423 T1009 T1008 prep in,migration
R424 T1010 T1011 det the,cerebellum
R425 T1011 T1009 pobj cerebellum,in
R426 T1012 T1013 punct [,10
R427 T1013 T1008 parataxis 10,migration
R428 T1014 T1013 punct ],10
R429 T1015 T955 punct .,studied
R430 T1017 T1018 det The,discovery
R431 T1018 T1019 nsubj discovery,prompted
R432 T1020 T1018 prep of,discovery
R433 T1021 T1022 amod multiple,roles
R434 T1022 T1020 pobj roles,of
R435 T1023 T1021 cc and,multiple
R436 T1024 T1021 conj diverse,multiple
R437 T1025 T1022 prep for,roles
R438 T1026 T1025 pobj PAX6,for
R439 T1027 T1022 prep in,roles
R440 T1028 T1029 compound brain,development
R441 T1029 T1027 pobj development,in
R442 T1030 T1031 compound MRI,analyses
R443 T1031 T1019 dobj analyses,prompted
R444 T1032 T1031 prep of,analyses
R445 T1033 T1034 compound aniridia,patients
R446 T1034 T1032 pobj patients,of
R447 T1035 T1019 punct ", ",prompted
R448 T1036 T1019 cc and,prompted
R449 T1037 T1038 det a,range
R450 T1038 T1039 nsubjpass range,uncovered
R451 T1039 T1019 conj uncovered,prompted
R452 T1040 T1038 prep of,range
R453 T1041 T1042 amod distinctive,anomalies
R454 T1042 T1040 pobj anomalies,of
R455 T1043 T1042 compound brain,anomalies
R456 T1044 T1039 auxpass were,uncovered
R457 T1045 T1039 punct .,uncovered
R458 T1047 T1048 det The,common
R459 T1048 T1050 nsubj common,was
R460 T1049 T1048 advmod most,common
R461 T1051 T1048 cc and,common
R462 T1052 T1048 conj striking,common
R463 T1053 T1048 prep of,common
R464 T1054 T1053 pobj these,of
R465 T1055 T1050 attr absence,was
R466 T1056 T1055 cc or,absence
R467 T1057 T1055 conj hypoplasia,absence
R468 T1058 T1055 prep of,absence
R469 T1059 T1060 det the,commissure
R470 T1060 T1058 pobj commissure,of
R471 T1061 T1060 amod anterior,commissure
R472 T1062 T1063 punct [,11
R473 T1063 T1050 parataxis 11,was
R474 T1064 T1063 punct ],11
R475 T1065 T1050 punct .,was
R476 T1067 T1068 amod Other,defects
R477 T1068 T1069 nsubj defects,included
R478 T1070 T1069 dobj absence,included
R479 T1071 T1070 cc or,absence
R480 T1072 T1070 conj hypoplasia,absence
R481 T1073 T1070 prep of,absence
R482 T1074 T1075 det the,gland
R483 T1075 T1073 pobj gland,of
R484 T1076 T1075 amod pineal,gland
R485 T1077 T1070 punct ", ",absence
R486 T1078 T1079 amod cortical,polymicrogyria
R487 T1079 T1070 conj polymicrogyria,absence
R488 T1080 T1079 punct ", ",polymicrogyria
R489 T1081 T1082 amod white,matter
R490 T1082 T1083 compound matter,changes
R491 T1083 T1079 conj changes,polymicrogyria
R492 T1084 T1083 prep in,changes
R493 T1085 T1086 det the,callosum
R494 T1086 T1084 pobj callosum,in
R495 T1087 T1086 compound corpus,callosum
R496 T1088 T1083 cc and,changes
R497 T1089 T1090 amod grey,matter
R498 T1090 T1091 compound matter,changes
R499 T1091 T1083 conj changes,changes
R500 T1092 T1091 prep in,changes
R501 T1093 T1094 det the,cerebellum
R502 T1094 T1092 pobj cerebellum,in
R503 T1095 T1096 punct [,11
R504 T1096 T1069 parataxis 11,included
R505 T1097 T1098 punct -,13
R506 T1098 T1096 prep 13,11
R507 T1099 T1096 punct ],11
R508 T1100 T1069 punct .,included
R509 T1102 T1103 amod Functional,changes
R510 T1103 T1104 nsubj changes,included
R511 T1105 T1104 dobj hyposmia,included
R512 T1106 T1105 cc and,hyposmia
R513 T1107 T1108 amod abnormal,transfer
R514 T1108 T1105 conj transfer,hyposmia
R515 T1109 T1108 amod inter-hemispheric,transfer
R516 T1110 T1108 amod auditory,transfer
R517 T1111 T1112 punct [,14
R518 T1112 T1104 parataxis 14,included
R519 T1113 T1112 nummod 11,14
R520 T1114 T1112 punct ",",14
R521 T1115 T1112 punct ],14
R522 T1116 T1104 punct .,included
R523 T1118 T1119 det The,feature
R524 T1119 T1121 nsubj feature,is
R525 T1120 T1119 amod defining,feature
R526 T1122 T1119 prep of,feature
R527 T1123 T1124 det all,proteins
R528 T1124 T1122 pobj proteins,of
R529 T1125 T1124 compound PAX,proteins
R530 T1126 T1127 det the,presence
R531 T1127 T1121 attr presence,is
R532 T1128 T1127 prep of,presence
R533 T1129 T1130 det a,domain
R534 T1130 T1128 pobj domain,of
R535 T1131 T1132 nummod 128,acid
R536 T1132 T1130 nmod acid,domain
R537 T1133 T1132 nmod amino,acid
R538 T1134 T1135 npadvmod DNA,binding
R539 T1135 T1130 amod binding,domain
R540 T1136 T1135 punct -,binding
R541 T1137 T1130 amod paired,domain
R542 T1138 T1139 dep that,conserved
R543 T1139 T1130 relcl conserved,domain
R544 T1140 T1139 aux has,conserved
R545 T1141 T1139 auxpass been,conserved
R546 T1142 T1139 advmod highly,conserved
R547 T1143 T1139 prep over,conserved
R548 T1144 T1143 pobj evolution,over
R549 T1145 T1146 punct [,1
R550 T1146 T1127 parataxis 1,presence
R551 T1147 T1146 punct ],1
R552 T1148 T1121 punct .,is
R553 T1150 T1151 prep In,contains
R554 T1152 T1150 pobj addition,In
R555 T1153 T1152 prep to,addition
R556 T1154 T1155 det the,domain
R557 T1155 T1153 pobj domain,to
R558 T1156 T1155 amod paired,domain
R559 T1157 T1151 punct ", ",contains
R560 T1158 T1151 nsubj PAX6,contains
R561 T1159 T1151 advmod also,contains
R562 T1160 T1161 det a,homeodomain
R563 T1161 T1151 dobj homeodomain,contains
R564 T1162 T1163 npadvmod DNA,binding
R565 T1163 T1161 amod binding,homeodomain
R566 T1164 T1163 punct -,binding
R567 T1165 T1161 cc and,homeodomain
R568 T1166 T1167 det a,domain
R569 T1167 T1161 conj domain,homeodomain
R570 T1168 T1169 npadvmod proline,rich
R571 T1169 T1167 amod rich,domain
R572 T1170 T1168 punct ", ",proline
R573 T1171 T1168 conj serine,proline
R574 T1172 T1171 cc and,serine
R575 T1173 T1171 conj threonine,serine
R576 T1174 T1169 punct -,rich
R577 T1175 T1176 punct (,PST
R578 T1176 T1167 parataxis PST,domain
R579 T1177 T1176 punct ),PST
R580 T1178 T1151 prep at,contains
R581 T1179 T1180 det the,terminus
R582 T1180 T1178 pobj terminus,at
R583 T1181 T1180 compound C,terminus
R584 T1182 T1180 punct -,terminus
R585 T1183 T1184 punct [,6
R586 T1184 T1151 parataxis 6,contains
R587 T1185 T1184 nummod 1,6
R588 T1186 T1184 punct ",",6
R589 T1187 T1184 punct ],6
R590 T1188 T1151 punct .,contains
R591 T1190 T1191 det The,domain
R592 T1191 T1193 nsubjpass domain,shown
R593 T1192 T1191 compound PST,domain
R594 T1194 T1191 punct ", ",domain
R595 T1195 T1196 dep which,encompasses
R596 T1196 T1191 relcl encompasses,domain
R597 T1197 T1198 det the,acids
R598 T1198 T1196 dobj acids,encompasses
R599 T1199 T1200 npadvmod C,terminal
R600 T1200 T1198 amod terminal,acids
R601 T1201 T1200 punct -,terminal
R602 T1202 T1198 nummod 145,acids
R603 T1203 T1198 compound amino,acids
R604 T1204 T1198 prep of,acids
R605 T1205 T1204 pobj PAX6,of
R606 T1206 T1193 punct ", ",shown
R607 T1207 T1193 aux has,shown
R608 T1208 T1193 auxpass been,shown
R609 T1209 T1210 aux to,act
R610 T1210 T1193 xcomp act,shown
R611 T1211 T1210 prep as,act
R612 T1212 T1213 det a,activator
R613 T1213 T1211 pobj activator,as
R614 T1214 T1213 amod transcriptional,activator
R615 T1215 T1216 punct [,6
R616 T1216 T1193 parataxis 6,shown
R617 T1217 T1216 punct ],6
R618 T1218 T1193 punct .,shown
R619 T1220 T1221 det The,protein
R620 T1221 T1223 nsubj protein,regulates
R621 T1222 T1221 compound PAX6,protein
R622 T1224 T1223 advmod directly,regulates
R623 T1225 T1226 det a,range
R624 T1226 T1223 dobj range,regulates
R625 T1227 T1226 amod wide,range
R626 T1228 T1226 prep of,range
R627 T1229 T1230 compound target,genes
R628 T1230 T1228 pobj genes,of
R629 T1231 T1232 punct [,2
R630 T1232 T1230 parataxis 2,genes
R631 T1233 T1232 nummod 1,2
R632 T1234 T1232 punct ",",2
R633 T1235 T1232 punct ],2
R634 T1236 T1226 prep including,range
R635 T1237 T1236 pobj Pax2,including
R636 T1238 T1239 punct [,15
R637 T1239 T1237 parataxis 15,Pax2
R638 T1240 T1239 punct ],15
R639 T1241 T1237 punct ", ",Pax2
R640 T1242 T1237 conj Ngn2,Pax2
R641 T1243 T1244 punct [,16
R642 T1244 T1242 parataxis 16,Ngn2
R643 T1245 T1244 punct ],16
R644 T1246 T1242 cc and,Ngn2
R645 T1247 T1242 conj glucagon,Ngn2
R646 T1248 T1249 punct [,17
R647 T1249 T1247 parataxis 17,glucagon
R648 T1250 T1249 punct ],17
R649 T1251 T1223 punct .,regulates
R650 T1253 T1254 det The,gene
R651 T1254 T1256 nsubj gene,has
R652 T1255 T1254 compound Pax6,gene
R653 T1257 T1258 det a,pattern
R654 T1258 T1256 dobj pattern,has
R655 T1259 T1260 advmod spatially,complex
R656 T1260 T1258 amod complex,pattern
R657 T1261 T1259 cc and,spatially
R658 T1262 T1259 conj temporally,spatially
R659 T1263 T1258 compound expression,pattern
R660 T1264 T1256 prep in,has
R661 T1265 T1266 det the,eye
R662 T1266 T1264 pobj eye,in
R663 T1267 T1266 punct ", ",eye
R664 T1268 T1266 conj brain,eye
R665 T1269 T1268 punct ", ",brain
R666 T1270 T1271 amod nasal,structures
R667 T1271 T1268 conj structures,brain
R668 T1272 T1271 punct ", ",structures
R669 T1273 T1274 amod spinal,cord
R670 T1274 T1271 conj cord,structures
R671 T1275 T1274 cc and,cord
R672 T1276 T1274 conj pancreas,cord
R673 T1277 T1278 punct [,1
R674 T1278 T1256 parataxis 1,has
R675 T1279 T1278 punct ],1
R676 T1280 T1256 punct .,has
R677 T1282 T1283 mark Although,involved
R678 T1283 T1287 advcl involved,emerging
R679 T1284 T1283 nsubjpass PAX6,involved
R680 T1285 T1283 auxpass is,involved
R681 T1286 T1283 advmod clearly,involved
R682 T1288 T1283 prep in,involved
R683 T1289 T1290 amod multiple,processes
R684 T1290 T1288 pobj processes,in
R685 T1291 T1290 amod developmental,processes
R686 T1292 T1287 punct ", ",emerging
R687 T1293 T1294 amod common,themes
R688 T1294 T1287 nsubj themes,emerging
R689 T1295 T1287 aux are,emerging
R690 T1296 T1287 advmod now,emerging
R691 T1297 T1287 prep concerning,emerging
R692 T1298 T1299 det the,role
R693 T1299 T1297 pobj role,concerning
R694 T1300 T1299 prep of,role
R695 T1301 T1300 pobj PAX6,of
R696 T1302 T1299 prep in,role
R697 T1303 T1304 amod neural,tissues
R698 T1304 T1302 pobj tissues,in
R699 T1305 T1287 punct .,emerging
R700 T1307 T1308 nsubj Gradients,are
R701 T1309 T1307 prep of,Gradients
R702 T1310 T1311 compound Pax6,expression
R703 T1311 T1309 pobj expression,of
R704 T1312 T1308 acomp important,are
R705 T1313 T1312 prep for,important
R706 T1314 T1313 pcomp determining,for
R707 T1315 T1316 amod positional,characteristics
R708 T1316 T1314 dobj characteristics,determining
R709 T1317 T1314 prep in,determining
R710 T1318 T1319 det the,retina
R711 T1319 T1317 pobj retina,in
R712 T1320 T1321 punct [,18
R713 T1321 T1319 parataxis 18,retina
R714 T1322 T1321 punct ],18
R715 T1323 T1319 cc and,retina
R716 T1324 T1325 det the,neocortex
R717 T1325 T1319 conj neocortex,retina
R718 T1326 T1327 punct [,7
R719 T1327 T1325 parataxis 7,neocortex
R720 T1328 T1327 punct ],7
R721 T1329 T1308 punct .,are
R722 T1331 T1332 nsubj PAX6,plays
R723 T1333 T1334 det a,role
R724 T1334 T1332 dobj role,plays
R725 T1335 T1332 prep in,plays
R726 T1336 T1335 pobj development,in
R727 T1337 T1336 prep of,development
R728 T1338 T1339 amod specific,connections
R729 T1339 T1337 pobj connections,of
R730 T1340 T1339 amod axonal,connections
R731 T1341 T1339 prep between,connections
R732 T1342 T1343 det the,retina
R733 T1343 T1341 pobj retina,between
R734 T1344 T1343 cc and,retina
R735 T1345 T1346 det the,brain
R736 T1346 T1343 conj brain,retina
R737 T1347 T1348 punct [,18
R738 T1348 T1346 parataxis 18,brain
R739 T1349 T1348 punct ],18
R740 T1350 T1341 cc and,between
R741 T1351 T1341 conj within,between
R742 T1352 T1353 det the,forebrain
R743 T1353 T1351 pobj forebrain,within
R744 T1354 T1355 punct [,19
R745 T1355 T1353 parataxis 19,forebrain
R746 T1356 T1355 nummod 8,19
R747 T1357 T1355 punct ",",19
R748 T1358 T1355 punct ],19
R749 T1359 T1332 punct .,plays
R750 T1361 T1362 nsubjpass It,involved
R751 T1363 T1362 auxpass is,involved
R752 T1364 T1362 advmod also,involved
R753 T1365 T1362 prep in,involved
R754 T1366 T1367 det the,differentiation
R755 T1367 T1365 pobj differentiation,in
R756 T1368 T1367 prep of,differentiation
R757 T1369 T1370 amod neural,types
R758 T1370 T1368 pobj types,of
R759 T1371 T1370 compound cell,types
R760 T1372 T1367 prep from,differentiation
R761 T1373 T1374 amod multipotent,precursors
R762 T1374 T1372 pobj precursors,from
R763 T1375 T1367 prep in,differentiation
R764 T1376 T1377 det the,retina
R765 T1377 T1375 pobj retina,in
R766 T1378 T1379 punct [,16
R767 T1379 T1377 parataxis 16,retina
R768 T1380 T1379 punct ],16
R769 T1381 T1377 cc and,retina
R770 T1382 T1383 det the,cortex
R771 T1383 T1377 conj cortex,retina
R772 T1384 T1383 amod cerebral,cortex
R773 T1385 T1386 punct [,9
R774 T1386 T1383 parataxis 9,cortex
R775 T1387 T1386 punct ],9
R776 T1388 T1362 prep through,involved
R777 T1389 T1388 pobj activation,through
R778 T1390 T1389 prep of,activation
R779 T1391 T1392 compound bHLH,genes
R780 T1392 T1390 pobj genes,of
R781 T1393 T1394 amod such,as
R782 T1394 T1392 prep as,genes
R783 T1395 T1394 pobj Ngn2,as
R784 T1396 T1395 cc and,Ngn2
R785 T1397 T1395 conj Mash1,Ngn2
R786 T1398 T1362 punct .,involved
R787 T1400 T1401 det These,studies
R788 T1401 T1402 nsubj studies,provide
R789 T1403 T1404 det a,link
R790 T1404 T1402 dobj link,provide
R791 T1405 T1404 amod clear,link
R792 T1406 T1404 prep between,link
R793 T1407 T1408 compound PAX6,function
R794 T1408 T1406 pobj function,between
R795 T1409 T1408 prep in,function
R796 T1410 T1411 det the,retina
R797 T1411 T1409 pobj retina,in
R798 T1412 T1411 cc and,retina
R799 T1413 T1414 det the,brain
R800 T1414 T1411 conj brain,retina
R801 T1415 T1402 punct ", ",provide
R802 T1416 T1402 cc and,provide
R803 T1417 T1402 conj are,provide
R804 T1418 T1417 prep of,are
R805 T1419 T1420 amod particular,relevance
R806 T1420 T1418 pobj relevance,of
R807 T1421 T1420 prep to,relevance
R808 T1422 T1423 det the,phenotypes
R809 T1423 T1421 pobj phenotypes,to
R810 T1424 T1423 amod neurological,phenotypes
R811 T1425 T1423 prep of,phenotypes
R812 T1426 T1425 pobj individuals,of
R813 T1427 T1426 prep with,individuals
R814 T1428 T1429 compound PAX6,mutations
R815 T1429 T1427 pobj mutations,with
R816 T1430 T1402 punct .,provide
R817 T1432 T1433 nsubj It,becoming
R818 T1434 T1433 aux is,becoming
R819 T1435 T1433 acomp apparent,becoming
R820 T1436 T1437 mark that,act
R821 T1437 T1433 ccomp act,becoming
R822 T1438 T1439 compound transcription,factors
R823 T1439 T1437 nsubj factors,act
R824 T1440 T1437 aux do,act
R825 T1441 T1437 neg not,act
R826 T1442 T1437 prep in,act
R827 T1443 T1442 pobj isolation,in
R828 T1444 T1437 cc but,act
R829 T1445 T1437 conj are,act
R830 T1446 T1445 acomp dependent,are
R831 T1447 T1446 prep on,dependent
R832 T1448 T1447 pobj interactions,on
R833 T1449 T1448 prep with,interactions
R834 T1450 T1451 amod other,proteins
R835 T1451 T1449 pobj proteins,with
R836 T1452 T1453 aux to,carry
R837 T1453 T1445 advcl carry,are
R838 T1454 T1453 prt out,carry
R839 T1455 T1456 poss their,function
R840 T1456 T1453 dobj function,carry
R841 T1457 T1458 punct [,21
R842 T1458 T1445 parataxis 21,are
R843 T1459 T1458 nummod 20,21
R844 T1460 T1458 punct ",",21
R845 T1461 T1458 punct ],21
R846 T1462 T1433 punct .,becoming
R847 T1464 T1465 det These,interactions
R848 T1465 T1466 nsubj interactions,introduce
R849 T1467 T1468 amod more,specificity
R850 T1468 T1466 dobj specificity,introduce
R851 T1469 T1466 prep into,introduce
R852 T1470 T1471 det the,function
R853 T1471 T1469 pobj function,into
R854 T1472 T1471 amod regulatory,function
R855 T1473 T1471 prep of,function
R856 T1474 T1475 det a,factor
R857 T1475 T1473 pobj factor,of
R858 T1476 T1475 amod given,factor
R859 T1477 T1475 compound transcription,factor
R860 T1478 T1466 punct .,introduce
R861 T1480 T1481 prep To,described
R862 T1482 T1480 pobj date,To
R863 T1483 T1484 advmod only,interactions
R864 T1484 T1481 nsubjpass interactions,described
R865 T1485 T1484 nummod three,interactions
R866 T1486 T1484 nmod PAX6,interactions
R867 T1487 T1488 nmod protein,protein
R868 T1488 T1484 compound protein,interactions
R869 T1489 T1488 punct -,protein
R870 T1490 T1481 aux have,described
R871 T1491 T1481 auxpass been,described
R872 T1492 T1481 punct : ,described
R873 T1493 T1481 prep with,described
R874 T1494 T1493 pobj SOX2,with
R875 T1495 T1494 prep on,SOX2
R876 T1496 T1497 det the,element
R877 T1497 T1495 pobj element,on
R878 T1498 T1499 npadvmod lens,specific
R879 T1499 T1497 amod specific,element
R880 T1500 T1499 punct -,specific
R881 T1501 T1497 compound enhancer,element
R882 T1502 T1497 prep of,element
R883 T1503 T1504 det the,gene
R884 T1504 T1502 pobj gene,of
R885 T1505 T1506 punct δ,crystallin
R886 T1506 T1504 compound crystallin,gene
R887 T1507 T1506 punct -,crystallin
R888 T1508 T1509 punct [,22
R889 T1509 T1493 parataxis 22,with
R890 T1510 T1509 punct ],22
R891 T1511 T1493 punct ;,with
R892 T1512 T1493 conj with,with
R893 T1513 T1512 pobj MDIA,with
R894 T1514 T1513 punct ", ",MDIA
R895 T1515 T1516 dep which,modulates
R896 T1516 T1513 relcl modulates,MDIA
R897 T1517 T1518 compound PAX6,activity
R898 T1518 T1516 dobj activity,modulates
R899 T1519 T1516 prep in,modulates
R900 T1520 T1521 amod early,development
R901 T1521 T1519 pobj development,in
R902 T1522 T1521 amod neuronal,development
R903 T1523 T1524 punct [,23
R904 T1524 T1513 parataxis 23,MDIA
R905 T1525 T1524 punct ],23
R906 T1526 T1512 punct ", ",with
R907 T1527 T1512 cc and,with
R908 T1528 T1512 conj with,with
R909 T1529 T1530 compound MAF,proteins
R910 T1530 T1528 pobj proteins,with
R911 T1531 T1530 prep on,proteins
R912 T1532 T1533 det the,promoter
R913 T1613 T1614 nummod two,hybrid
R914 T1533 T1531 pobj promoter,on
R915 T1534 T1533 compound glucagon,promoter
R916 T1614 T1611 compound hybrid,technique
R917 T1615 T1614 punct -,hybrid
R918 T1535 T1533 punct ", ",promoter
R919 T1616 T1601 cc and,screened
R920 T1617 T1601 conj identified,screened
R921 T1618 T1619 nummod three,proteins
R922 T1536 T1537 dep which,causes
R923 T1619 T1617 dobj proteins,identified
R924 T1620 T1619 amod novel,proteins
R925 T1537 T1533 relcl causes,promoter
R926 T1621 T1619 amod interacting,proteins
R927 T1622 T1619 punct ", ",proteins
R928 T1623 T1619 appos HOMER3,proteins
R929 T1624 T1623 punct ", ",HOMER3
R930 T1625 T1623 conj DNCL1,HOMER3
R931 T1626 T1625 cc and,DNCL1
R932 T1538 T1539 amod increased,expression
R933 T1627 T1625 conj TRIM11,DNCL1
R934 T1628 T1601 punct .,screened
R935 T1539 T1537 dobj expression,causes
R936 T1630 T1631 det The,interaction
R937 T1631 T1632 nsubjpass interaction,disrupted
R938 T1540 T1539 prep of,expression
R939 T1633 T1631 prep between,interaction
R940 T1634 T1633 pobj PAX6,between
R941 T1541 T1542 det this,gene
R942 T1635 T1634 cc and,PAX6
R943 T1636 T1637 det these,proteins
R944 T1542 T1540 pobj gene,of
R945 T1637 T1634 conj proteins,PAX6
R946 T1638 T1632 auxpass was,disrupted
R947 T1639 T1632 agent by,disrupted
R948 T1543 T1542 amod pancreatic,gene
R949 T1640 T1641 advmod naturally,occurring
R950 T1641 T1642 amod occurring,mutations
R951 T1544 T1542 compound hormone,gene
R952 T1545 T1546 punct [,17
R953 T1642 T1639 pobj mutations,by
R954 T1643 T1644 npadvmod C,terminal
R955 T1546 T1528 parataxis 17,with
R956 T1644 T1642 amod terminal,mutations
R957 T1547 T1546 punct ],17
R958 T1645 T1644 punct -,terminal
R959 T1646 T1642 compound PAX6,mutations
R960 T1647 T1632 punct .,disrupted
R961 T1548 T1481 punct .,described
R962 T1550 T1551 advmod Here,report
R963 T1552 T1551 nsubj we,report
R964 T1553 T1554 det the,results
R965 T1554 T1551 dobj results,report
R966 T1555 T1554 amod preliminary,results
R967 T1556 T1554 prep of,results
R968 T1557 T1558 det the,screen
R969 T1558 T1556 pobj screen,of
R970 T1559 T1558 amod first,screen
R971 T1560 T1558 amod systematic,screen
R972 T1561 T1558 prep for,screen
R973 T1562 T1561 pobj proteins,for
R974 T1563 T1564 dep that,interact
R975 T1564 T1562 relcl interact,proteins
R976 T1565 T1564 prep with,interact
R977 T1566 T1565 pobj PAX6,with
R978 T1567 T1551 punct .,report
R979 T1569 T1570 nsubj We,used
R980 T1571 T1572 compound sequence,alignment
R981 T1572 T1573 compound alignment,algorithms
R982 T1573 T1570 dobj algorithms,used
R983 T1574 T1573 cc and,algorithms
R984 T1575 T1576 amod secondary,structure
R985 T1576 T1577 compound structure,prediction
R986 T1577 T1578 compound prediction,programs
R987 T1578 T1573 conj programs,algorithms
R988 T1579 T1580 aux to,define
R989 T1580 T1570 advcl define,used
R990 T1581 T1582 det a,domain
R991 T1582 T1580 dobj domain,define
R992 T1583 T1582 amod new,domain
R993 T1584 T1582 prep of,domain
R994 T1585 T1586 nummod 32,acids
R995 T1586 T1584 pobj acids,of
R996 T1587 T1586 compound amino,acids
R997 T1588 T1580 prep at,define
R998 T1589 T1590 det the,end
R999 T1590 T1588 pobj end,at
R1000 T1591 T1592 npadvmod C,terminal
R1001 T1592 T1590 amod terminal,end
R1002 T1593 T1592 punct -,terminal
R1003 T1594 T1590 prep of,end
R1004 T1595 T1596 det the,protein
R1005 T1596 T1594 pobj protein,of
R1006 T1597 T1596 compound PAX6,protein
R1007 T1598 T1570 punct .,used
R1008 T1600 T1601 nsubj We,screened
R1009 T1602 T1601 advmod then,screened
R1010 T1603 T1604 det a,library
R1011 T1604 T1601 dobj library,screened
R1012 T1605 T1604 compound brain,library
R1013 T1606 T1601 prep with,screened
R1014 T1607 T1608 det this,peptide
R1015 T1608 T1606 pobj peptide,with
R1016 T1609 T1601 advcl using,screened
R1017 T1610 T1611 det the,technique
R1018 T1611 T1609 dobj technique,using
R1019 T1612 T1611 nmod yeast,technique

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T665 15-19 PR_EXT:000012318 denotes PAX6
T666 20-27 CHEBI_PR_EXT:protein denotes protein
T667 47-50 PR_EXT:000037797 denotes PAX
T668 52-62 PR_EXT:000037797 denotes paired-box
T669 74-89 GO_EXT:transcription denotes transcriptional
T670 90-100 GO_EXT:regulator denotes regulators
T671 129-135 UBERON:0000970 denotes ocular
T672 129-135 _FRAGMENT denotes ocular
T673 147-158 GO:0001654 denotes development
T674 140-146 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T675 140-158 GO:0007399 denotes neural development
T676 177-186 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T677 194-199 NCBITaxon:9606 denotes human
T678 200-204 PR_EXT:000012318 denotes PAX6
T679 205-209 SO_EXT:0000704 denotes gene
T680 241-245 UBERON:0001769 denotes iris
T681 279-282 UBERON:0000970 denotes eye
T682 302-308 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes Neural
T683 325-331 UBERON:0001786 denotes foveal
T684 347-358 UBERON_EXT:optic_nerve denotes optic nerve
T685 384-388 PR_EXT:000012318 denotes PAX6
T686 400-403 UBERON:0000970 denotes eye
T687 430-439 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T688 443-446 NCBITaxon:9606 denotes man
T689 451-456 NCBITaxon:10088 denotes mouse
T690 461-467 GO_EXT:fatality_or_lethality denotes lethal
T691 565-574 GO:0007608 denotes olfactory
T692 596-601 UBERON:0000955 denotes brain
T693 636-640 PR_EXT:000012318 denotes PAX6
T694 644-649 UBERON:0000955 denotes brain
T695 644-661 GO:0007420 denotes brain development
T696 701-707 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T697 708-712 NCBITaxon:10088 denotes mice
T698 716-720 NCBITaxon:10114 denotes rats
T699 753-768 UBERON:0000956 denotes cerebral cortex
T700 774-786 _FRAGMENT denotes formation of
T701 791-828 GO:0021905 denotes prosencephalon-mesencephalon boundary
T702 791-805 UBERON:0001890 denotes prosencephalon
T703 806-819 UBERON:0001891 denotes mesencephalon
T704 834-838 GO:0030424 denotes axon
T705 834-847 GO:0007411 denotes axon guidance
T706 853-868 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T707 872-879 CL:0000540 denotes neurons
T708 885-889 CL:0000125 denotes glia
T709 898-906 CL:0000540 denotes neuronal
T710 898-916 GO:0001764 denotes neuronal migration
T711 924-934 UBERON:0002037 denotes cerebellum
T712 989-993 PR_EXT:000012318 denotes PAX6
T713 997-1002 UBERON:0000955 denotes brain
T714 997-1014 GO:0007420 denotes brain development
T715 1086-1091 UBERON:0000955 denotes brain
T716 1189-1208 UBERON:0000935 denotes anterior commissure
T717 1267-1279 UBERON:0011768 denotes pineal gland
T718 1281-1289 UBERON:0001851 denotes cortical
T719 1306-1318 UBERON:0002316 denotes white matter
T720 1334-1349 UBERON:0002336 denotes corpus callosum
T721 1354-1365 UBERON:0002020 denotes grey matter
T722 1381-1391 UBERON:0002037 denotes cerebellum
T723 1469-1477 GO:0007605 denotes auditory
T724 1478-1486 GO_EXT:biological_movement_or_translocation_process denotes transfer
T725 1524-1527 PR_EXT:000037797 denotes PAX
T726 1528-1536 CHEBI_PR_EXT:protein denotes proteins
T727 1562-1572 CHEBI_SO_EXT:amino_acid denotes amino acid
T728 1573-1576 CHEBI_SO_EXT:DNA denotes DNA
T729 1577-1584 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T730 1592-1598 SO_EXT:0000417 denotes domain
T731 1620-1629 SO_EXT:biological_conservation_process_or_quality denotes conserved
T732 1676-1682 SO_EXT:0000417 denotes domain
T733 1684-1688 PR_EXT:000012318 denotes PAX6
T734 1705-1708 CHEBI_SO_EXT:DNA denotes DNA
T735 1709-1716 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T736 1735-1742 CHEBI_SO_EXT:proline denotes proline
T737 1744-1750 CHEBI_SO_EXT:serine denotes serine
T738 1755-1764 CHEBI_SO_EXT:threonine denotes threonine
T739 1776-1782 SO_EXT:0000417 denotes domain
T740 1790-1800 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminus
T741 1816-1822 SO_EXT:0000417 denotes domain
T742 1846-1856 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T743 1861-1872 CHEBI_SO_EXT:amino_acid denotes amino acids
T744 1876-1880 PR_EXT:000012318 denotes PAX6
T745 1909-1924 GO_EXT:transcription denotes transcriptional
T746 1944-1948 PR_EXT:000012318 denotes PAX6
T747 1949-1956 CHEBI_PR_EXT:protein denotes protein
T748 1966-1975 GO:0065007 denotes regulates
T749 1999-2004 SO_EXT:0000704 denotes genes
T750 2021-2025 PR_EXT:000012315 denotes Pax2
T751 2032-2036 PR_EXT:000011157 denotes Ngn2
T752 2046-2054 CHEBI_PR_EXT:glucagon denotes glucagon
T753 2065-2069 PR_EXT:000012318 denotes Pax6
T754 2070-2074 SO_EXT:0000704 denotes gene
T755 2114-2124 GO:0010467 denotes expression
T756 2140-2143 UBERON:0000970 denotes eye
T757 2145-2150 UBERON:0000955 denotes brain
T758 2152-2157 UBERON:0000004 denotes nasal
T759 2170-2181 UBERON:0002240 denotes spinal cord
T760 2186-2194 UBERON:0001264 denotes pancreas
T761 2209-2213 PR_EXT:000012318 denotes PAX6
T762 2325-2329 PR_EXT:000012318 denotes PAX6
T763 2333-2347 UBERON:0003714 denotes neural tissues
T764 2362-2366 PR_EXT:000012318 denotes Pax6
T765 2367-2377 GO:0010467 denotes expression
T766 2442-2448 UBERON:0000966 denotes retina
T767 2462-2471 UBERON:0001950 denotes neocortex
T768 2477-2481 PR_EXT:000012318 denotes PAX6
T769 2522-2528 GO:0030424 denotes axonal
T770 2553-2559 UBERON:0000966 denotes retina
T771 2568-2573 UBERON:0000955 denotes brain
T772 2594-2603 UBERON:0001890 denotes forebrain
T773 2639-2654 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T774 2658-2664 UBERON_EXT:neural_tissue_or_nerve_or_nervous_system denotes neural
T775 2658-2669 CL:0002319 denotes neural cell
T776 2665-2669 CL_GO_EXT:cell denotes cell
T777 2711-2717 UBERON:0000966 denotes retina
T778 2731-2746 UBERON:0000956 denotes cerebral cortex
T779 2778-2783 SO_EXT:0000704 denotes genes
T780 2792-2796 PR_EXT:000011157 denotes Ngn2
T781 2801-2806 PR_EXT:000004362 denotes Mash1
T782 2851-2855 PR_EXT:000012318 denotes PAX6
T783 2872-2878 UBERON:0000966 denotes retina
T784 2887-2892 UBERON:0000955 denotes brain
T785 2933-2945 UBERON:0001016 denotes neurological
T786 2960-2971 NCBITaxon:1 denotes individuals
T787 2977-2981 PR_EXT:000012318 denotes PAX6
T788 2982-2991 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T790 3022-3043 GO_EXT:transcription_factor denotes transcription factors
T791 3113-3121 CHEBI_PR_EXT:protein denotes proteins
T792 3214-3224 GO:0065007 denotes regulatory
T793 3245-3258 GO_EXT:transcription denotes transcription
T794 3245-3265 GO_EXT:transcription_factor denotes transcription factor
T795 3286-3290 PR_EXT:000012318 denotes PAX6
T796 3291-3298 CHEBI_PR_EXT:protein denotes protein
T797 3299-3306 CHEBI_PR_EXT:protein denotes protein
T798 3346-3350 PR_EXT:000015426 denotes SOX2
T799 3358-3362 UBERON_EXT:lens denotes lens
T800 3372-3380 SO_EXT:0000165 denotes enhancer
T801 3409-3413 SO_EXT:0000704 denotes gene
T802 3437-3446 GO:0065007 denotes modulates
T803 3447-3451 PR_EXT:000012318 denotes PAX6
T804 3470-3478 CL:0000540 denotes neuronal
T805 3470-3490 GO_EXT:neuron_development_or_generation denotes neuronal development
T806 3510-3518 CHEBI_PR_EXT:protein denotes proteins
T807 3526-3534 CHEBI_PR_EXT:glucagon denotes glucagon
T808 3535-3543 SO_EXT:0000167 denotes promoter
T809 3568-3581 _FRAGMENT denotes expression of
T810 3606-3610 GO:0010467 denotes gene
T811 3587-3597 UBERON:0001264 denotes pancreatic
T812 3598-3605 CHEBI_GO_EXT:hormone denotes hormone
T813 3606-3610 SO_EXT:0000704 denotes gene
T814 3691-3699 CHEBI_PR_EXT:protein denotes proteins
T815 3719-3723 PR_EXT:000012318 denotes PAX6
T816 3733-3741 SO_EXT:biological_sequence denotes sequence
T817 3823-3829 SO_EXT:0000417 denotes domain
T818 3836-3847 CHEBI_SO_EXT:amino_acid denotes amino acids
T819 3855-3865 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T820 3877-3881 PR_EXT:000012318 denotes PAX6
T821 3882-3889 CHEBI_PR_EXT:protein denotes protein
T822 3910-3915 UBERON:0000955 denotes brain
T823 3934-3941 CHEBI_SO_EXT:peptide_or_peptide_region denotes peptide
T824 3952-3957 NCBITaxon_EXT:yeast denotes yeast
T825 4018-4026 CHEBI_PR_EXT:protein denotes proteins
T826 4028-4034 PR_EXT:000008680 denotes HOMER3
T827 4036-4041 PR_EXT:000002325 denotes DNCL1
T828 4046-4052 PR_EXT:000016642 denotes TRIM11
T829 4078-4082 PR_EXT:000012318 denotes PAX6
T830 4093-4101 CHEBI_PR_EXT:protein denotes proteins
T831 4139-4149 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T832 4150-4154 PR_EXT:000012318 denotes PAX6
T833 4155-4164 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T789 3022-3035 GO_EXT:transcription denotes transcription
R254 T673 T672 _lexicallyChainedTo development,ocular
R255 T701 T700 _lexicallyChainedTo prosencephalon-mesencephalon boundary,formation of
R256 T810 T809 _lexicallyChainedTo gene,expression of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T550 15-19 PR:000012318 denotes PAX6
T551 47-50 PR:000037797 denotes PAX
T552 52-62 PR:000037797 denotes paired-box
T553 129-135 UBERON:0000970 denotes ocular
T554 129-135 _FRAGMENT denotes ocular
T555 147-158 GO:0001654 denotes development
T556 140-158 GO:0007399 denotes neural development
T557 194-199 NCBITaxon:9606 denotes human
T558 200-204 PR:000012318 denotes PAX6
T559 205-209 SO:0000704 denotes gene
T560 241-245 UBERON:0001769 denotes iris
T561 279-282 UBERON:0000970 denotes eye
T562 325-331 UBERON:0001786 denotes foveal
T563 347-352 UBERON:0000970 denotes optic
T564 384-388 PR:000012318 denotes PAX6
T565 400-403 UBERON:0000970 denotes eye
T566 443-446 NCBITaxon:9606 denotes man
T567 451-456 NCBITaxon:10088 denotes mouse
T568 565-574 GO:0007608 denotes olfactory
T569 596-601 UBERON:0000955 denotes brain
T570 636-640 PR:000012318 denotes PAX6
T571 644-649 UBERON:0000955 denotes brain
T572 644-661 GO:0007420 denotes brain development
T573 708-712 NCBITaxon:10088 denotes mice
T574 716-720 NCBITaxon:10114 denotes rats
T575 753-768 UBERON:0000956 denotes cerebral cortex
T576 774-786 _FRAGMENT denotes formation of
T577 791-828 GO:0021905 denotes prosencephalon-mesencephalon boundary
T578 791-805 UBERON:0001890 denotes prosencephalon
T579 806-819 UBERON:0001891 denotes mesencephalon
T581 834-847 GO:0007411 denotes axon guidance
T582 872-879 CL:0000540 denotes neurons
T583 885-889 CL:0000125 denotes glia
T584 898-906 CL:0000540 denotes neuronal
T585 898-916 GO:0001764 denotes neuronal migration
T586 924-934 UBERON:0002037 denotes cerebellum
T587 989-993 PR:000012318 denotes PAX6
T588 997-1002 UBERON:0000955 denotes brain
T589 997-1014 GO:0007420 denotes brain development
T590 1086-1091 UBERON:0000955 denotes brain
T591 1189-1208 UBERON:0000935 denotes anterior commissure
T592 1267-1279 UBERON:0011768 denotes pineal gland
T593 1281-1289 UBERON:0001851 denotes cortical
T594 1306-1318 UBERON:0002316 denotes white matter
T595 1334-1349 UBERON:0002336 denotes corpus callosum
T596 1354-1365 UBERON:0002020 denotes grey matter
T597 1381-1391 UBERON:0002037 denotes cerebellum
T598 1469-1477 GO:0007605 denotes auditory
T599 1524-1527 PR:000037797 denotes PAX
T600 1592-1598 SO:0000417 denotes domain
T601 1676-1682 SO:0000417 denotes domain
T602 1684-1688 PR:000012318 denotes PAX6
T603 1776-1782 SO:0000417 denotes domain
T604 1816-1822 SO:0000417 denotes domain
T605 1876-1880 PR:000012318 denotes PAX6
T606 1944-1948 PR:000012318 denotes PAX6
T607 1966-1975 GO:0065007 denotes regulates
T608 1999-2004 SO:0000704 denotes genes
T609 2021-2025 PR:000012315 denotes Pax2
T610 2032-2036 PR:000011157 denotes Ngn2
T611 2065-2069 PR:000012318 denotes Pax6
T612 2070-2074 SO:0000704 denotes gene
T613 2114-2124 GO:0010467 denotes expression
T614 2140-2143 UBERON:0000970 denotes eye
T615 2145-2150 UBERON:0000955 denotes brain
T616 2152-2157 UBERON:0000004 denotes nasal
T617 2170-2181 UBERON:0002240 denotes spinal cord
T618 2186-2194 UBERON:0001264 denotes pancreas
T619 2209-2213 PR:000012318 denotes PAX6
T620 2325-2329 PR:000012318 denotes PAX6
T621 2333-2347 UBERON:0003714 denotes neural tissues
T622 2362-2366 PR:000012318 denotes Pax6
T623 2367-2377 GO:0010467 denotes expression
T624 2442-2448 UBERON:0000966 denotes retina
T625 2462-2471 UBERON:0001950 denotes neocortex
T626 2477-2481 PR:000012318 denotes PAX6
T627 2522-2528 GO:0030424 denotes axonal
T628 2553-2559 UBERON:0000966 denotes retina
T629 2568-2573 UBERON:0000955 denotes brain
T630 2594-2603 UBERON:0001890 denotes forebrain
T631 2658-2669 CL:0002319 denotes neural cell
T632 2711-2717 UBERON:0000966 denotes retina
T633 2731-2746 UBERON:0000956 denotes cerebral cortex
T634 2778-2783 SO:0000704 denotes genes
T635 2792-2796 PR:000011157 denotes Ngn2
T636 2801-2806 PR:000004362 denotes Mash1
T637 2851-2855 PR:000012318 denotes PAX6
T638 2872-2878 UBERON:0000966 denotes retina
T639 2887-2892 UBERON:0000955 denotes brain
T640 2933-2945 UBERON:0001016 denotes neurological
T641 2960-2971 NCBITaxon:1 denotes individuals
T642 2977-2981 PR:000012318 denotes PAX6
T643 3214-3224 GO:0065007 denotes regulatory
T644 3286-3290 PR:000012318 denotes PAX6
T645 3346-3350 PR:000015426 denotes SOX2
T646 3372-3380 SO:0000165 denotes enhancer
T647 3409-3413 SO:0000704 denotes gene
T648 3437-3446 GO:0065007 denotes modulates
T649 3447-3451 PR:000012318 denotes PAX6
T650 3470-3478 CL:0000540 denotes neuronal
T651 3535-3543 SO:0000167 denotes promoter
T652 3568-3581 _FRAGMENT denotes expression of
T653 3606-3610 GO:0010467 denotes gene
T654 3587-3597 UBERON:0001264 denotes pancreatic
T655 3606-3610 SO:0000704 denotes gene
T656 3719-3723 PR:000012318 denotes PAX6
T657 3823-3829 SO:0000417 denotes domain
T658 3877-3881 PR:000012318 denotes PAX6
T659 3910-3915 UBERON:0000955 denotes brain
T660 4028-4034 PR:000008680 denotes HOMER3
T661 4036-4041 PR:000002325 denotes DNCL1
T662 4046-4052 PR:000016642 denotes TRIM11
T663 4078-4082 PR:000012318 denotes PAX6
T664 4150-4154 PR:000012318 denotes PAX6
T580 834-838 GO:0030424 denotes axon
R251 T555 T554 _lexicallyChainedTo development,ocular
R252 T577 T576 _lexicallyChainedTo prosencephalon-mesencephalon boundary,formation of
R253 T653 T652 _lexicallyChainedTo gene,expression of