PMC:1208879 / 0-572 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1208879","sourcedb":"PMC","sourceid":"1208879","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1208879","text":"A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11\n\nAbstract\nBackground\nThe PAX6 protein is a transcriptional regulator with a key role in ocular and neurological development. Individuals with heterozygous loss-of-function mutations in the PAX6 gene have malformations of the eye and brain. Little is known about the interactions of PAX6 with other proteins, so we carried out a systematic screen for proteins that interact with PAX6.\n\nResults\nWe used bioinformatics techniques to characterise a highly 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