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PMC:1208879 / 0-572 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T176 2-8 NN denotes screen
T177 0-117 sentence denotes A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11
T178 68-75 VBP denotes disrupt
T179 9-12 IN denotes for
T180 13-21 NN denotes proteins
T181 22-26 WDT denotes that
T182 27-35 VBP denotes interact
T183 36-40 IN denotes with
T184 41-45 NN denotes PAX6
T185 45-47 : denotes :
T186 47-48 NN denotes C
T187 49-57 JJ denotes terminal
T188 48-49 HYPH denotes -
T189 58-67 NNS denotes mutations
T190 76-87 NN denotes interaction
T191 88-92 IN denotes with
T192 93-99 NN denotes HOMER3
T193 99-101 , denotes ,
T194 101-106 NN denotes DNCL1
T195 107-110 CC denotes and
T196 111-117 NN denotes TRIM11
T197 117-118 sentence denotes
T198 128-138 sentence denotes Background
T199 128-138 NN denotes Background
T200 138-242 sentence denotes The PAX6 protein is a transcriptional regulator with a key role in ocular and neurological development.
T201 139-142 DT denotes The
T202 148-155 NN denotes protein
T203 143-147 NN denotes PAX6
T204 156-158 VBZ denotes is
T205 159-160 DT denotes a
T206 177-186 NN denotes regulator
T207 161-176 JJ denotes transcriptional
T208 187-191 IN denotes with
T209 192-193 DT denotes a
T210 198-202 NN denotes role
T211 194-197 JJ denotes key
T212 203-205 IN denotes in
T213 206-212 JJ denotes ocular
T214 230-241 NN denotes development
T215 213-216 CC denotes and
T216 217-229 JJ denotes neurological
T217 241-242 . denotes .
T218 242-357 sentence denotes Individuals with heterozygous loss-of-function mutations in the PAX6 gene have malformations of the eye and brain.
T219 243-254 NNS denotes Individuals
T220 317-321 VBP denotes have
T221 255-259 IN denotes with
T222 260-272 JJ denotes heterozygous
T223 290-299 NNS denotes mutations
T224 273-277 NN denotes loss
T225 277-278 HYPH denotes -
T226 278-280 IN denotes of
T227 280-281 HYPH denotes -
T228 281-289 NN denotes function
T229 300-302 IN denotes in
T230 303-306 DT denotes the
T231 312-316 NN denotes gene
T232 307-311 NN denotes PAX6
T233 322-335 NNS denotes malformations
T234 336-338 IN denotes of
T235 339-342 DT denotes the
T236 343-346 NN denotes eye
T237 347-350 CC denotes and
T238 351-356 NN denotes brain
T239 356-357 . denotes .
T240 357-501 sentence denotes Little is known about the interactions of PAX6 with other proteins, so we carried out a systematic screen for proteins that interact with PAX6.
T241 358-364 NN denotes Little
T242 368-373 VBN denotes known
T243 365-367 VBZ denotes is
T244 374-379 IN denotes about
T245 380-383 DT denotes the
T246 384-396 NNS denotes interactions
T247 397-399 IN denotes of
T248 400-404 NN denotes PAX6
T249 405-409 IN denotes with
T250 410-415 JJ denotes other
T251 416-424 NN denotes proteins
T252 424-426 , denotes ,
T253 426-428 CC denotes so
T254 429-431 PRP denotes we
T255 432-439 VBD denotes carried
T256 440-443 RP denotes out
T257 444-445 DT denotes a
T258 457-463 NN denotes screen
T259 446-456 JJ denotes systematic
T260 464-467 IN denotes for
T261 468-476 NN denotes proteins
T262 477-481 WDT denotes that
T263 482-490 VBP denotes interact
T264 491-495 IN denotes with
T265 496-500 NN denotes PAX6
T266 500-501 . denotes .
T267 501-510 sentence denotes Results
T268 503-510 NNS denotes Results
T270 511-513 PRP denotes We
T271 514-518 VBD denotes used
T272 519-533 NN denotes bioinformatics
T273 534-544 NNS denotes techniques
T274 545-547 TO denotes to
T275 548-560 VB denotes characterise
T276 561-562 DT denotes a
T278 563-569 RB denotes highly
T175 0-1 DT denotes A
R11 T187 T189 amod terminal,mutations
R12 T188 T187 punct -,terminal
R22 T202 T204 nsubj protein,is
R23 T203 T202 compound PAX6,protein
R25 T206 T204 attr regulator,is
R26 T207 T206 amod transcriptional,regulator
R29 T210 T208 pobj role,with
R30 T211 T210 amod key,role
R33 T214 T212 pobj development,in
R34 T215 T213 cc and,ocular
R35 T216 T213 conj neurological,ocular
R40 T223 T221 pobj mutations,with
R41 T224 T223 nmod loss,mutations
R42 T225 T224 punct -,loss
R43 T226 T224 prep of,loss
R44 T227 T226 punct -,of
R45 T228 T226 pobj function,of
R48 T231 T229 pobj gene,in
R49 T232 T231 compound PAX6,gene
R73 T258 T255 dobj screen,carried
R74 T259 T258 amod systematic,screen
R250 T175 T176 det A,screen
R2 T176 T178 dep screen,disrupt
R3 T179 T176 prep for,screen
R4 T180 T179 pobj proteins,for
R5 T181 T182 dep that,interact
R6 T182 T180 relcl interact,proteins
R7 T183 T182 prep with,interact
R8 T184 T183 pobj PAX6,with
R9 T185 T178 punct : ,disrupt
R10 T186 T187 npadvmod C,terminal
R13 T189 T178 nsubj mutations,disrupt
R14 T190 T178 dobj interaction,disrupt
R15 T191 T190 prep with,interaction
R16 T192 T191 pobj HOMER3,with
R17 T193 T192 punct ", ",HOMER3
R18 T194 T192 conj DNCL1,HOMER3
R19 T195 T194 cc and,DNCL1
R20 T196 T194 conj TRIM11,DNCL1
R21 T201 T202 det The,protein
R24 T205 T206 det a,regulator
R27 T208 T206 prep with,regulator
R28 T209 T210 det a,role
R31 T212 T210 prep in,role
R32 T213 T214 amod ocular,development
R36 T217 T204 punct .,is
R37 T219 T220 nsubj Individuals,have
R38 T221 T219 prep with,Individuals
R39 T222 T223 amod heterozygous,mutations
R46 T229 T219 prep in,Individuals
R47 T230 T231 det the,gene
R50 T233 T220 dobj malformations,have
R51 T234 T233 prep of,malformations
R52 T235 T236 det the,eye
R53 T236 T234 pobj eye,of
R54 T237 T236 cc and,eye
R55 T238 T236 conj brain,eye
R56 T239 T220 punct .,have
R57 T241 T242 nsubjpass Little,known
R58 T243 T242 auxpass is,known
R59 T244 T242 prep about,known
R60 T245 T246 det the,interactions
R61 T246 T244 pobj interactions,about
R62 T247 T246 prep of,interactions
R63 T248 T247 pobj PAX6,of
R64 T249 T246 prep with,interactions
R65 T250 T251 amod other,proteins
R66 T251 T249 pobj proteins,with
R67 T252 T242 punct ", ",known
R68 T253 T242 cc so,known
R69 T254 T255 nsubj we,carried
R70 T255 T242 conj carried,known
R71 T256 T255 prt out,carried
R72 T257 T258 det a,screen
R75 T260 T258 prep for,screen
R76 T261 T260 pobj proteins,for
R77 T262 T263 dep that,interact
R78 T263 T261 relcl interact,proteins
R79 T264 T263 prep with,interact
R80 T265 T264 pobj PAX6,with
R81 T266 T255 punct .,carried
R82 T270 T271 nsubj We,used
R83 T272 T273 compound bioinformatics,techniques
R84 T273 T271 dobj techniques,used
R85 T274 T275 aux to,characterise
R86 T275 T271 advcl characterise,used

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T104 13-21 CHEBI_PR_EXT:protein denotes proteins
T105 41-45 PR_EXT:000012318 denotes PAX6
T106 47-57 CHEBI_SO_EXT:C_terminus_or_C_terminal_region denotes C-terminal
T107 58-67 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T108 93-99 PR_EXT:000008680 denotes HOMER3
T109 101-106 PR_EXT:000002325 denotes DNCL1
T110 111-117 PR_EXT:000016642 denotes TRIM11
T111 143-147 PR_EXT:000012318 denotes PAX6
T112 148-155 CHEBI_PR_EXT:protein denotes protein
T113 161-176 GO_EXT:transcription denotes transcriptional
T114 177-186 GO_EXT:regulator denotes regulator
T115 206-212 UBERON:0000970 denotes ocular
T116 206-212 _FRAGMENT denotes ocular
T117 230-241 GO:0001654 denotes development
T118 217-229 UBERON:0001016 denotes neurological
T119 217-241 GO:0007399 denotes neurological development
T120 243-254 NCBITaxon:1 denotes Individuals
T121 290-299 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T122 307-311 PR_EXT:000012318 denotes PAX6
T123 312-316 SO_EXT:0000704 denotes gene
T124 343-346 UBERON:0000970 denotes eye
T125 351-356 UBERON:0000955 denotes brain
T126 400-404 PR_EXT:000012318 denotes PAX6
T127 416-424 CHEBI_PR_EXT:protein denotes proteins
T128 468-476 CHEBI_PR_EXT:protein denotes proteins
T129 496-500 PR_EXT:000012318 denotes PAX6
R1 T117 T116 _lexicallyChainedTo development,ocular

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T62 41-45 PR:000012318 denotes PAX6
T63 93-99 PR:000008680 denotes HOMER3
T64 101-106 PR:000002325 denotes DNCL1
T65 111-117 PR:000016642 denotes TRIM11
T66 143-147 PR:000012318 denotes PAX6
T67 206-212 UBERON:0000970 denotes ocular
T68 206-212 _FRAGMENT denotes ocular
T69 230-241 GO:0001654 denotes development
T70 217-229 UBERON:0001016 denotes neurological
T71 217-241 GO:0007399 denotes neurological development
T72 243-254 NCBITaxon:1 denotes Individuals
T73 307-311 PR:000012318 denotes PAX6
T74 312-316 SO:0000704 denotes gene
T75 343-346 UBERON:0000970 denotes eye
T76 351-356 UBERON:0000955 denotes brain
T77 400-404 PR:000012318 denotes PAX6
T78 496-500 PR:000012318 denotes PAX6
R249 T69 T68 _lexicallyChainedTo development,ocular