Id |
Subject |
Object |
Predicate |
Lexical cue |
T1518 |
0-5 |
DT |
denotes |
These |
T1519 |
6-17 |
NNS |
denotes |
experiments |
T1520 |
18-30 |
VBD |
denotes |
demonstrated |
T1521 |
31-41 |
JJ |
denotes |
widespread |
T1522 |
45-55 |
NN |
denotes |
regulation |
T1523 |
42-44 |
JJ |
denotes |
up |
T1524 |
44-45 |
HYPH |
denotes |
- |
T1525 |
56-58 |
IN |
denotes |
of |
T1526 |
59-63 |
NN |
denotes |
cone |
T1527 |
64-72 |
JJ |
denotes |
specific |
T1528 |
63-64 |
HYPH |
denotes |
- |
T1529 |
91-96 |
NNS |
denotes |
genes |
T1530 |
73-76 |
CC |
denotes |
and |
T1531 |
77-81 |
NN |
denotes |
cone |
T1532 |
82-90 |
VBN |
denotes |
enriched |
T1533 |
81-82 |
HYPH |
denotes |
- |
T1534 |
97-99 |
IN |
denotes |
in |
T1535 |
100-103 |
DT |
denotes |
the |
T1536 |
108-114 |
NN |
denotes |
retina |
T1537 |
104-107 |
NN |
denotes |
rd7 |
T1538 |
114-116 |
, |
denotes |
, |
T1539 |
116-126 |
RB |
denotes |
especially |
T1540 |
127-129 |
IN |
denotes |
by |
T1541 |
130-139 |
JJ |
denotes |
postnatal |
T1542 |
140-143 |
NN |
denotes |
day |
T1543 |
144-146 |
CD |
denotes |
14 |
T1544 |
147-148 |
-LRB- |
denotes |
( |
T1545 |
148-151 |
NN |
denotes |
P14 |
T1546 |
151-152 |
-RRB- |
denotes |
) |
T1547 |
153-156 |
CC |
denotes |
and |
T1548 |
157-160 |
NN |
denotes |
P21 |
T1549 |
161-162 |
-LRB- |
denotes |
( |
T1550 |
162-168 |
NN |
denotes |
Figure |
T1551 |
169-170 |
CD |
denotes |
1 |
T1552 |
170-171 |
-RRB- |
denotes |
) |
T1553 |
171-172 |
. |
denotes |
. |
T1554 |
172-290 |
sentence |
denotes |
Most known cone-specific or cone-enriched genes were found to be up-regulated in the mutant (Figure 1, genes G1–G15). |
T1555 |
173-177 |
JJS |
denotes |
Most |
T1556 |
215-220 |
NNS |
denotes |
genes |
T1557 |
178-183 |
JJ |
denotes |
known |
T1558 |
184-188 |
NN |
denotes |
cone |
T1559 |
189-197 |
JJ |
denotes |
specific |
T1560 |
188-189 |
HYPH |
denotes |
- |
T1561 |
198-200 |
CC |
denotes |
or |
T1562 |
201-205 |
NN |
denotes |
cone |
T1563 |
206-214 |
VBN |
denotes |
enriched |
T1564 |
205-206 |
HYPH |
denotes |
- |
T1565 |
226-231 |
VBN |
denotes |
found |
T1566 |
221-225 |
VBD |
denotes |
were |
T1567 |
232-234 |
TO |
denotes |
to |
T1568 |
241-250 |
VBN |
denotes |
regulated |
T1569 |
235-237 |
VB |
denotes |
be |
T1570 |
238-240 |
RB |
denotes |
up |
T1571 |
240-241 |
HYPH |
denotes |
- |
T1572 |
251-253 |
IN |
denotes |
in |
T1573 |
254-257 |
DT |
denotes |
the |
T1574 |
258-264 |
NN |
denotes |
mutant |
T1575 |
265-266 |
-LRB- |
denotes |
( |
T1576 |
266-272 |
NN |
denotes |
Figure |
T1577 |
273-274 |
CD |
denotes |
1 |
T1578 |
274-276 |
, |
denotes |
, |
T1579 |
276-281 |
NNS |
denotes |
genes |
T1580 |
282-284 |
NN |
denotes |
G1 |
T1581 |
284-285 |
SYM |
denotes |
– |
T1582 |
285-288 |
NN |
denotes |
G15 |
T1583 |
288-289 |
-RRB- |
denotes |
) |
T1584 |
289-290 |
. |
denotes |
. |
T1585 |
290-433 |
sentence |
denotes |
The majority of these genes represent components of the phototransduction cascade (e.g., opsins, transducins, and phosphodiesterase subunits). |
T1586 |
291-294 |
DT |
denotes |
The |
T1587 |
295-303 |
NN |
denotes |
majority |
T1588 |
319-328 |
VBP |
denotes |
represent |
T1589 |
304-306 |
IN |
denotes |
of |
T1590 |
307-312 |
DT |
denotes |
these |
T1591 |
313-318 |
NNS |
denotes |
genes |
T1592 |
329-339 |
NNS |
denotes |
components |
T1593 |
340-342 |
IN |
denotes |
of |
T1594 |
343-346 |
DT |
denotes |
the |
T1595 |
365-372 |
NN |
denotes |
cascade |
T1596 |
347-364 |
NN |
denotes |
phototransduction |
T1597 |
373-374 |
-LRB- |
denotes |
( |
T1598 |
380-386 |
NNS |
denotes |
opsins |
T1599 |
374-378 |
FW |
denotes |
e.g. |
T1600 |
378-380 |
, |
denotes |
, |
T1601 |
386-388 |
, |
denotes |
, |
T1602 |
388-399 |
NNS |
denotes |
transducins |
T1603 |
399-401 |
, |
denotes |
, |
T1604 |
401-404 |
CC |
denotes |
and |
T1605 |
405-422 |
NN |
denotes |
phosphodiesterase |
T1606 |
423-431 |
NNS |
denotes |
subunits |
T1607 |
431-432 |
-RRB- |
denotes |
) |
T1608 |
432-433 |
. |
denotes |
. |
T1609 |
433-629 |
sentence |
denotes |
In addition to these genes, several novel cone-specific genes of unknown function recently identified in our lab were also up-regulated (Figure 1, genes G16, G17, G21, and G24; unpublished data). |
T1610 |
434-436 |
IN |
denotes |
In |
T1611 |
560-569 |
VBN |
denotes |
regulated |
T1612 |
437-445 |
NN |
denotes |
addition |
T1613 |
446-448 |
IN |
denotes |
to |
T1614 |
449-454 |
DT |
denotes |
these |
T1615 |
455-460 |
NNS |
denotes |
genes |
T1616 |
460-462 |
, |
denotes |
, |
T1617 |
462-469 |
JJ |
denotes |
several |
T1618 |
490-495 |
NNS |
denotes |
genes |
T1619 |
470-475 |
JJ |
denotes |
novel |
T1620 |
476-480 |
NN |
denotes |
cone |
T1621 |
481-489 |
JJ |
denotes |
specific |
T1622 |
480-481 |
HYPH |
denotes |
- |
T1623 |
496-498 |
IN |
denotes |
of |
T1624 |
499-506 |
JJ |
denotes |
unknown |
T1625 |
507-515 |
NN |
denotes |
function |
T1626 |
516-524 |
RB |
denotes |
recently |
T1627 |
525-535 |
VBN |
denotes |
identified |
T1628 |
536-538 |
IN |
denotes |
in |
T1629 |
539-542 |
PRP$ |
denotes |
our |
T1630 |
543-546 |
NN |
denotes |
lab |
T1631 |
547-551 |
VBD |
denotes |
were |
T1632 |
552-556 |
RB |
denotes |
also |
T1633 |
557-559 |
RB |
denotes |
up |
T1634 |
559-560 |
HYPH |
denotes |
- |
T1635 |
570-571 |
-LRB- |
denotes |
( |
T1636 |
623-627 |
NNS |
denotes |
data |
T1637 |
571-577 |
NNP |
denotes |
Figure |
T1638 |
578-579 |
CD |
denotes |
1 |
T1639 |
579-581 |
, |
denotes |
, |
T1640 |
581-586 |
NNS |
denotes |
genes |
T1641 |
587-590 |
NN |
denotes |
G16 |
T1642 |
590-592 |
, |
denotes |
, |
T1643 |
592-595 |
NN |
denotes |
G17 |
T1644 |
595-597 |
, |
denotes |
, |
T1645 |
597-600 |
NN |
denotes |
G21 |
T1646 |
600-602 |
, |
denotes |
, |
T1647 |
602-605 |
CC |
denotes |
and |
T1648 |
606-609 |
NN |
denotes |
G24 |
T1649 |
609-610 |
: |
denotes |
; |
T1650 |
611-622 |
JJ |
denotes |
unpublished |
T1651 |
627-628 |
-RRB- |
denotes |
) |
T1652 |
628-629 |
. |
denotes |
. |
T1653 |
629-824 |
sentence |
denotes |
Finally, a wide range of other genes, most with no previously recognized role in the retina, were found to be up-regulated in the rd7 mutant (Figure 1, G26–G53; Tables S1 and S2; Figures S1–S7). |
T1654 |
630-637 |
RB |
denotes |
Finally |
T1655 |
728-733 |
VBN |
denotes |
found |
T1656 |
637-639 |
, |
denotes |
, |
T1657 |
639-640 |
DT |
denotes |
a |
T1658 |
646-651 |
NN |
denotes |
range |
T1659 |
641-645 |
JJ |
denotes |
wide |
T1660 |
652-654 |
IN |
denotes |
of |
T1661 |
655-660 |
JJ |
denotes |
other |
T1662 |
661-666 |
NNS |
denotes |
genes |
T1663 |
666-668 |
, |
denotes |
, |
T1664 |
668-672 |
DT |
denotes |
most |
T1665 |
673-677 |
IN |
denotes |
with |
T1666 |
678-680 |
DT |
denotes |
no |
T1667 |
703-707 |
NN |
denotes |
role |
T1668 |
681-691 |
RB |
denotes |
previously |
T1669 |
692-702 |
VBN |
denotes |
recognized |
T1670 |
708-710 |
IN |
denotes |
in |
T1671 |
711-714 |
DT |
denotes |
the |
T1672 |
715-721 |
NN |
denotes |
retina |
T1673 |
721-723 |
, |
denotes |
, |
T1674 |
723-727 |
VBD |
denotes |
were |
T1675 |
734-736 |
TO |
denotes |
to |
T1676 |
743-752 |
VBN |
denotes |
regulated |
T1677 |
737-739 |
VB |
denotes |
be |
T1678 |
740-742 |
RB |
denotes |
up |
T1679 |
742-743 |
HYPH |
denotes |
- |
T1680 |
753-755 |
IN |
denotes |
in |
T1681 |
756-759 |
DT |
denotes |
the |
T1682 |
764-770 |
NN |
denotes |
mutant |
T1683 |
760-763 |
NN |
denotes |
rd7 |
T1684 |
771-772 |
-LRB- |
denotes |
( |
T1685 |
772-778 |
NN |
denotes |
Figure |
T1686 |
779-780 |
CD |
denotes |
1 |
T1687 |
780-782 |
, |
denotes |
, |
T1688 |
782-785 |
NN |
denotes |
G26 |
T1689 |
785-786 |
SYM |
denotes |
– |
T1690 |
786-789 |
NN |
denotes |
G53 |
T1691 |
789-790 |
: |
denotes |
; |
T1692 |
791-797 |
NNS |
denotes |
Tables |
T1693 |
798-800 |
NN |
denotes |
S1 |
T1694 |
801-804 |
CC |
denotes |
and |
T1695 |
805-807 |
NN |
denotes |
S2 |
T1696 |
807-808 |
: |
denotes |
; |
T1697 |
809-816 |
NNS |
denotes |
Figures |
T1698 |
817-819 |
NN |
denotes |
S1 |
T1699 |
819-820 |
SYM |
denotes |
– |
T1700 |
820-822 |
NN |
denotes |
S7 |
T1701 |
822-823 |
-RRB- |
denotes |
) |
T1702 |
823-824 |
. |
denotes |
. |
R943 |
T1518 |
T1519 |
det |
These,experiments |
R944 |
T1519 |
T1520 |
nsubj |
experiments,demonstrated |
R945 |
T1521 |
T1522 |
amod |
widespread,regulation |
R946 |
T1522 |
T1520 |
dobj |
regulation,demonstrated |
R947 |
T1523 |
T1522 |
amod |
up,regulation |
R948 |
T1524 |
T1522 |
punct |
-,regulation |
R949 |
T1525 |
T1522 |
prep |
of,regulation |
R950 |
T1526 |
T1527 |
npadvmod |
cone,specific |
R951 |
T1527 |
T1529 |
amod |
specific,genes |
R952 |
T1528 |
T1527 |
punct |
-,specific |
R953 |
T1529 |
T1525 |
pobj |
genes,of |
R954 |
T1530 |
T1527 |
cc |
and,specific |
R955 |
T1531 |
T1532 |
npadvmod |
cone,enriched |
R956 |
T1532 |
T1527 |
conj |
enriched,specific |
R957 |
T1533 |
T1532 |
punct |
-,enriched |
R958 |
T1534 |
T1522 |
prep |
in,regulation |
R959 |
T1535 |
T1536 |
det |
the,retina |
R960 |
T1536 |
T1534 |
pobj |
retina,in |
R961 |
T1537 |
T1536 |
compound |
rd7,retina |
R962 |
T1538 |
T1522 |
punct |
", ",regulation |
R963 |
T1539 |
T1540 |
advmod |
especially,by |
R964 |
T1540 |
T1522 |
prep |
by,regulation |
R965 |
T1541 |
T1542 |
amod |
postnatal,day |
R966 |
T1542 |
T1540 |
pobj |
day,by |
R967 |
T1543 |
T1542 |
nummod |
14,day |
R968 |
T1544 |
T1542 |
punct |
(,day |
R969 |
T1545 |
T1542 |
appos |
P14,day |
R970 |
T1546 |
T1542 |
punct |
),day |
R971 |
T1547 |
T1542 |
cc |
and,day |
R972 |
T1548 |
T1542 |
conj |
P21,day |
R973 |
T1549 |
T1550 |
punct |
(,Figure |
R974 |
T1550 |
T1522 |
parataxis |
Figure,regulation |
R975 |
T1551 |
T1550 |
nummod |
1,Figure |
R976 |
T1552 |
T1550 |
punct |
),Figure |
R977 |
T1553 |
T1520 |
punct |
.,demonstrated |
R978 |
T1555 |
T1556 |
amod |
Most,genes |
R979 |
T1556 |
T1565 |
nsubjpass |
genes,found |
R980 |
T1557 |
T1556 |
amod |
known,genes |
R981 |
T1558 |
T1559 |
npadvmod |
cone,specific |
R982 |
T1559 |
T1556 |
amod |
specific,genes |
R983 |
T1560 |
T1559 |
punct |
-,specific |
R984 |
T1561 |
T1559 |
cc |
or,specific |
R985 |
T1562 |
T1563 |
npadvmod |
cone,enriched |
R986 |
T1563 |
T1559 |
conj |
enriched,specific |
R987 |
T1564 |
T1563 |
punct |
-,enriched |
R988 |
T1566 |
T1565 |
auxpass |
were,found |
R989 |
T1567 |
T1568 |
aux |
to,regulated |
R990 |
T1568 |
T1565 |
xcomp |
regulated,found |
R991 |
T1569 |
T1568 |
auxpass |
be,regulated |
R992 |
T1570 |
T1568 |
advmod |
up,regulated |
R993 |
T1571 |
T1568 |
punct |
-,regulated |
R994 |
T1572 |
T1568 |
prep |
in,regulated |
R995 |
T1573 |
T1574 |
det |
the,mutant |
R996 |
T1574 |
T1572 |
pobj |
mutant,in |
R997 |
T1575 |
T1576 |
punct |
(,Figure |
R998 |
T1576 |
T1565 |
parataxis |
Figure,found |
R999 |
T1577 |
T1576 |
nummod |
1,Figure |
R1000 |
T1578 |
T1576 |
punct |
", ",Figure |
R1001 |
T1579 |
T1580 |
compound |
genes,G1 |
R1002 |
T1580 |
T1576 |
appos |
G1,Figure |
R1003 |
T1581 |
T1582 |
punct |
–,G15 |
R1004 |
T1582 |
T1580 |
prep |
G15,G1 |
R1005 |
T1583 |
T1576 |
punct |
),Figure |
R1006 |
T1584 |
T1565 |
punct |
.,found |
R1007 |
T1586 |
T1587 |
det |
The,majority |
R1008 |
T1587 |
T1588 |
nsubj |
majority,represent |
R1009 |
T1589 |
T1587 |
prep |
of,majority |
R1010 |
T1590 |
T1591 |
det |
these,genes |
R1011 |
T1591 |
T1589 |
pobj |
genes,of |
R1012 |
T1592 |
T1588 |
dobj |
components,represent |
R1013 |
T1593 |
T1592 |
prep |
of,components |
R1014 |
T1594 |
T1595 |
det |
the,cascade |
R1015 |
T1595 |
T1593 |
pobj |
cascade,of |
R1016 |
T1596 |
T1595 |
compound |
phototransduction,cascade |
R1017 |
T1597 |
T1598 |
punct |
(,opsins |
R1018 |
T1598 |
T1595 |
parataxis |
opsins,cascade |
R1019 |
T1599 |
T1598 |
advmod |
e.g.,opsins |
R1020 |
T1600 |
T1598 |
punct |
", ",opsins |
R1021 |
T1601 |
T1598 |
punct |
", ",opsins |
R1022 |
T1602 |
T1598 |
conj |
transducins,opsins |
R1023 |
T1603 |
T1602 |
punct |
", ",transducins |
R1024 |
T1604 |
T1602 |
cc |
and,transducins |
R1025 |
T1605 |
T1606 |
compound |
phosphodiesterase,subunits |
R1026 |
T1606 |
T1602 |
conj |
subunits,transducins |
R1027 |
T1607 |
T1598 |
punct |
),opsins |
R1028 |
T1608 |
T1588 |
punct |
.,represent |
R1029 |
T1610 |
T1611 |
prep |
In,regulated |
R1030 |
T1612 |
T1610 |
pobj |
addition,In |
R1031 |
T1613 |
T1612 |
prep |
to,addition |
R1032 |
T1614 |
T1615 |
det |
these,genes |
R1033 |
T1615 |
T1613 |
pobj |
genes,to |
R1034 |
T1616 |
T1611 |
punct |
", ",regulated |
R1035 |
T1617 |
T1618 |
amod |
several,genes |
R1036 |
T1618 |
T1611 |
nsubjpass |
genes,regulated |
R1037 |
T1619 |
T1618 |
amod |
novel,genes |
R1038 |
T1620 |
T1621 |
npadvmod |
cone,specific |
R1039 |
T1621 |
T1618 |
amod |
specific,genes |
R1040 |
T1622 |
T1621 |
punct |
-,specific |
R1041 |
T1623 |
T1618 |
prep |
of,genes |
R1042 |
T1624 |
T1625 |
amod |
unknown,function |
R1043 |
T1625 |
T1623 |
pobj |
function,of |
R1044 |
T1626 |
T1627 |
advmod |
recently,identified |
R1045 |
T1627 |
T1618 |
acl |
identified,genes |
R1046 |
T1628 |
T1627 |
prep |
in,identified |
R1047 |
T1629 |
T1630 |
poss |
our,lab |
R1048 |
T1630 |
T1628 |
pobj |
lab,in |
R1049 |
T1631 |
T1611 |
auxpass |
were,regulated |
R1050 |
T1632 |
T1611 |
advmod |
also,regulated |
R1051 |
T1633 |
T1611 |
advmod |
up,regulated |
R1052 |
T1634 |
T1611 |
punct |
-,regulated |
R1053 |
T1635 |
T1636 |
punct |
(,data |
R1054 |
T1636 |
T1611 |
parataxis |
data,regulated |
R1055 |
T1637 |
T1636 |
dep |
Figure,data |
R1056 |
T1638 |
T1637 |
nummod |
1,Figure |
R1057 |
T1639 |
T1637 |
punct |
", ",Figure |
R1058 |
T1640 |
T1641 |
compound |
genes,G16 |
R1059 |
T1641 |
T1637 |
appos |
G16,Figure |
R1060 |
T1642 |
T1641 |
punct |
", ",G16 |
R1061 |
T1643 |
T1641 |
conj |
G17,G16 |
R1062 |
T1644 |
T1643 |
punct |
", ",G17 |
R1063 |
T1645 |
T1643 |
conj |
G21,G17 |
R1064 |
T1646 |
T1645 |
punct |
", ",G21 |
R1065 |
T1647 |
T1645 |
cc |
and,G21 |
R1066 |
T1648 |
T1645 |
conj |
G24,G21 |
R1067 |
T1649 |
T1636 |
punct |
;,data |
R1068 |
T1650 |
T1636 |
amod |
unpublished,data |
R1069 |
T1651 |
T1636 |
punct |
),data |
R1070 |
T1652 |
T1611 |
punct |
.,regulated |
R1071 |
T1654 |
T1655 |
advmod |
Finally,found |
R1072 |
T1656 |
T1655 |
punct |
", ",found |
R1073 |
T1657 |
T1658 |
det |
a,range |
R1074 |
T1658 |
T1655 |
nsubjpass |
range,found |
R1075 |
T1659 |
T1658 |
amod |
wide,range |
R1076 |
T1660 |
T1658 |
prep |
of,range |
R1077 |
T1661 |
T1662 |
amod |
other,genes |
R1078 |
T1662 |
T1660 |
pobj |
genes,of |
R1079 |
T1663 |
T1662 |
punct |
", ",genes |
R1080 |
T1664 |
T1665 |
nsubj |
most,with |
R1081 |
T1665 |
T1662 |
relcl |
with,genes |
R1082 |
T1666 |
T1667 |
det |
no,role |
R1083 |
T1667 |
T1665 |
pobj |
role,with |
R1084 |
T1668 |
T1669 |
advmod |
previously,recognized |
R1085 |
T1669 |
T1667 |
amod |
recognized,role |
R1086 |
T1670 |
T1667 |
prep |
in,role |
R1087 |
T1671 |
T1672 |
det |
the,retina |
R1088 |
T1672 |
T1670 |
pobj |
retina,in |
R1089 |
T1673 |
T1655 |
punct |
", ",found |
R1090 |
T1674 |
T1655 |
auxpass |
were,found |
R1091 |
T1675 |
T1676 |
aux |
to,regulated |
R1092 |
T1676 |
T1655 |
xcomp |
regulated,found |
R1093 |
T1677 |
T1676 |
auxpass |
be,regulated |
R1094 |
T1678 |
T1676 |
advmod |
up,regulated |
R1095 |
T1679 |
T1676 |
punct |
-,regulated |
R1096 |
T1680 |
T1676 |
prep |
in,regulated |
R1097 |
T1681 |
T1682 |
det |
the,mutant |
R1098 |
T1682 |
T1680 |
pobj |
mutant,in |
R1099 |
T1683 |
T1682 |
compound |
rd7,mutant |
R1100 |
T1684 |
T1685 |
punct |
(,Figure |
R1101 |
T1685 |
T1655 |
parataxis |
Figure,found |
R1102 |
T1686 |
T1685 |
nummod |
1,Figure |
R1103 |
T1687 |
T1685 |
punct |
", ",Figure |
R1104 |
T1688 |
T1685 |
appos |
G26,Figure |
R1105 |
T1689 |
T1690 |
punct |
–,G53 |
R1106 |
T1690 |
T1688 |
prep |
G53,G26 |
R1107 |
T1691 |
T1685 |
punct |
;,Figure |
R1108 |
T1692 |
T1693 |
compound |
Tables,S1 |
R1109 |
T1693 |
T1685 |
appos |
S1,Figure |
R1110 |
T1694 |
T1693 |
cc |
and,S1 |
R1111 |
T1695 |
T1693 |
conj |
S2,S1 |
R1112 |
T1696 |
T1685 |
punct |
;,Figure |
R1113 |
T1697 |
T1698 |
compound |
Figures,S1 |
R1114 |
T1698 |
T1685 |
appos |
S1,Figure |
R1115 |
T1699 |
T1700 |
punct |
–,S7 |
R1116 |
T1700 |
T1698 |
prep |
S7,S1 |
R1117 |
T1701 |
T1685 |
punct |
),Figure |
R1118 |
T1702 |
T1655 |
punct |
.,found |