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of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data)."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T5208","span":{"begin":20,"end":33},"obj":"CL:0000210"},{"id":"T5209","span":{"begin":34,"end":47},"obj":"GO_EXT:transcription"},{"id":"T5210","span":{"begin":34,"end":55},"obj":"GO_EXT:transcription_factor"},{"id":"T5211","span":{"begin":67,"end":73},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T5212","span":{"begin":103,"end":106},"obj":"PR_EXT:000005904"},{"id":"T5213","span":{"begin":111,"end":114},"obj":"PR_EXT:000011432"},{"id":"T5214","span":{"begin":137,"end":143},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T5215","span":{"begin":197,"end":200},"obj":"PR_EXT:000011432"},{"id":"T5216","span":{"begin":206,"end":209},"obj":"CL:0000604"},{"id":"T5217","span":{"begin":220,"end":225},"obj":"CHEBI_EXT:22695"},{"id":"T5218","span":{"begin":226,"end":233},"obj":"CHEBI_SO_EXT:leucine"},{"id":"T5219","span":{"begin":241,"end":254},"obj":"GO_EXT:transcription"},{"id":"T5220","span":{"begin":241,"end":261},"obj":"GO_EXT:transcription_factor"},{"id":"T5221","span":{"begin":298,"end":301},"obj":"CL:0000604"},{"id":"T5222","span":{"begin":311,"end":316},"obj":"SO_EXT:0000704"},{"id":"T5223","span":{"begin":344,"end":348},"obj":"CL:0000573"},{"id":"T5224","span":{"begin":358,"end":363},"obj":"SO_EXT:0000704"},{"id":"T5225","span":{"begin":367,"end":371},"obj":"CL:0000604"},{"id":"T5226","span":{"begin":378,"end":381},"obj":"PR_EXT:000011432"},{"id":"T5227","span":{"begin":397,"end":408},"obj":"SO_EXT:0000704"},{"id":"T5228","span":{"begin":421,"end":426},"obj":"PR_EXT:000011403"},{"id":"T5229","span":{"begin":451,"end":461},"obj":"GO:0010467"},{"id":"T5230","span":{"begin":468,"end":471},"obj":"PR_EXT:000005904"},{"id":"T5231","span":{"begin":486,"end":499},"obj":"GO_EXT:transcription"},{"id":"T5232","span":{"begin":486,"end":506},"obj":"GO_EXT:transcription_factor"},{"id":"T5233","span":{"begin":507,"end":516},"obj":"GO:0010467"},{"id":"T5234","span":{"begin":525,"end":529},"obj":"CL:0000604"},{"id":"T5235","span":{"begin":534,"end":539},"obj":"CL:0000573"},{"id":"T5236","span":{"begin":564,"end":574},"obj":"GO:0010467"},{"id":"T5237","span":{"begin":591,"end":594},"obj":"CL:0000604"},{"id":"T5238","span":{"begin":600,"end":604},"obj":"CL:0000573"},{"id":"T5239","span":{"begin":614,"end":619},"obj":"SO_EXT:0000704"},{"id":"T5240","span":{"begin":661,"end":664},"obj":"PR_EXT:000011432"},{"id":"T5241","span":{"begin":665,"end":671},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T5242","span":{"begin":673,"end":678},"obj":"PR_EXT:000011403"},{"id":"T5243","span":{"begin":679,"end":689},"obj":"GO:0010467"},{"id":"T5244","span":{"begin":706,"end":709},"obj":"PR_EXT:000005904"},{"id":"T5245","span":{"begin":710,"end":716},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"}],"text":"Analysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data)."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T5142","span":{"begin":20,"end":33},"obj":"CL:0000210"},{"id":"T5143","span":{"begin":103,"end":106},"obj":"PR:000005904"},{"id":"T5144","span":{"begin":111,"end":114},"obj":"PR:000011432"},{"id":"T5145","span":{"begin":197,"end":200},"obj":"PR:000011432"},{"id":"T5146","span":{"begin":206,"end":209},"obj":"CL:0000604"},{"id":"T5147","span":{"begin":220,"end":225},"obj":"CHEBI:22695"},{"id":"T5148","span":{"begin":298,"end":301},"obj":"CL:0000604"},{"id":"T5149","span":{"begin":311,"end":316},"obj":"SO:0000704"},{"id":"T5150","span":{"begin":344,"end":348},"obj":"CL:0000573"},{"id":"T5151","span":{"begin":358,"end":363},"obj":"SO:0000704"},{"id":"T5152","span":{"begin":367,"end":371},"obj":"CL:0000604"},{"id":"T5153","span":{"begin":378,"end":381},"obj":"PR:000011432"},{"id":"T5154","span":{"begin":397,"end":408},"obj":"SO:0000704"},{"id":"T5155","span":{"begin":421,"end":426},"obj":"PR:000011403"},{"id":"T5156","span":{"begin":451,"end":461},"obj":"GO:0010467"},{"id":"T5157","span":{"begin":468,"end":471},"obj":"PR:000005904"},{"id":"T5158","span":{"begin":507,"end":516},"obj":"GO:0010467"},{"id":"T5159","span":{"begin":525,"end":529},"obj":"CL:0000604"},{"id":"T5160","span":{"begin":534,"end":539},"obj":"CL:0000573"},{"id":"T5161","span":{"begin":564,"end":574},"obj":"GO:0010467"},{"id":"T5162","span":{"begin":591,"end":594},"obj":"CL:0000604"},{"id":"T5163","span":{"begin":600,"end":604},"obj":"CL:0000573"},{"id":"T5164","span":{"begin":614,"end":619},"obj":"SO:0000704"},{"id":"T5165","span":{"begin":661,"end":664},"obj":"PR:000011432"},{"id":"T5166","span":{"begin":673,"end":678},"obj":"PR:000011403"},{"id":"T5167","span":{"begin":679,"end":689},"obj":"GO:0010467"},{"id":"T5168","span":{"begin":706,"end":709},"obj":"PR:000005904"}],"text":"Analysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data)."}

{"project":"2_test","denotations":[{"id":"16110338-11694879-85798521","span":{"begin":373,"end":375},"obj":"11694879"},{"id":"16110338-11694879-85798522","span":{"begin":463,"end":465},"obj":"11694879"},{"id":"16110338-10581037-85798523","span":{"begin":621,"end":623},"obj":"10581037"},{"id":"T85266","span":{"begin":373,"end":375},"obj":"11694879"},{"id":"T4282","span":{"begin":463,"end":465},"obj":"11694879"},{"id":"T41962","span":{"begin":621,"end":623},"obj":"10581037"}],"text":"Analysis of several photoreceptor transcription factors in the rd7 mutant indicated that the levels of Crx and Nrl are unaffected in the mutant at P14 (see Figure 2, lower right photomicrographs). Nrl is a rod-specific, basic leucine zipper transcription factor required for the activation of many rod-specific genes and the repression of most cone-specific genes in rods [24]. Nrl is known to be genetically upstream of Nr2e3 and is required for its expression [24]. Crx is a homeobox transcription factor expressed in both rods and cones and is required for the expression of a variety of rod- and cone-specific genes [25]. In contrast to what is seen in the Nrl mutant, Nr2e3 expression is unchanged in Crx mutant homozygotes (unpublished data)."}