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ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains \u003e 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T6331","span":{"begin":1086,"end":1093},"obj":"GO:0065007"},{"id":"T6330","span":{"begin":1080,"end":1085},"obj":"SO_EXT:0000704"},{"id":"T6329","span":{"begin":761,"end":767},"obj":"GO_EXT:taster"},{"id":"T6328","span":{"begin":691,"end":696},"obj":"GO:0050909"},{"id":"T6327","span":{"begin":253,"end":258},"obj":"GO:0050909"},{"id":"T6326","span":{"begin":119,"end":123},"obj":"NCBITaxon:10088"}],"text":"Lick ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains \u003e 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T6325","span":{"begin":1086,"end":1093},"obj":"GO:0065007"},{"id":"T6324","span":{"begin":1080,"end":1085},"obj":"SO:0000704"},{"id":"T6323","span":{"begin":691,"end":696},"obj":"GO:0050909"},{"id":"T6322","span":{"begin":253,"end":258},"obj":"GO:0050909"},{"id":"T6321","span":{"begin":119,"end":123},"obj":"NCBITaxon:10088"}],"text":"Lick ratios (mean ± SE) for B6, D2 and BXD strains. (A) Mean lick ratios for B6 (filled circles) and D2 (open circles) mice at two concentrations of QHCl and DB. In all panels, a lower mean lick ratio indicates a greater aversion, and therefore greater taste sensitivity, to the stimulus. For panels B, C, and D, each BXD strain is represented by a different color, and listed in order from least sensitive to most sensitive to 1 mM QHCL. (B) Mean lick ratios for the six BXD strains that are most sensitive to QHCl in this assay. (C) Mean lick ratios for the five BXD strains that are least sensitive to QHCl in this assay. (D) Mean lick ratios for the six BXD strains intermediate in QHCl taste sensitivity to those in (B) and (C). Cutoffs for the three QHCl taster groups were arbitrarily set, as there was a continuity of the phenotype at 1 mM QHCl: sensitive strains exhibited a lick ratio for 1 mM QHCl of ≤ 0.3, intermediate strains from 0.31-0.6, and insensitive strains \u003e 0.6. The absence of two distinct phenotypic classes suggests that sensitivity to QHCL is under polygenic control."}