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used brief-access behavioral taste testing of BXD/Ty recombinant inbred (RI) mouse strains to map the major quantitative trait locus (QTL) for taste sensitivity to QHCl. This QTL is restricted to a ~5 Mb interval on chromosome 6 that includes 24 genes encoding T2Rs (Tas2rs). Tas2rs at this locus display in total 307 coding region single nucleotide polymorphisms (SNPs) between the two BXD/Ty RI parental strains, C57BL/6J (quinine-sensitive) and DBA/2J (quinine insensitive); approximately 50% of these mutations are silent. Individual RI lines contain exclusively either C57BL/6J or DBA/2J Tas2r alleles at this locus, and RI lines containing C57BL/6J Tas2r alleles are more sensitive to QHCl than are lines containing DBA/2J alleles. Thus, the entire Tas2r cluster comprises a large haplotype that correlates with quinine taster status."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T80","span":{"begin":21,"end":31},"obj":"GO_PATO_EXT:biological_behavior"},{"id":"T81","span":{"begin":32,"end":37},"obj":"GO:0050909"},{"id":"T82","span":{"begin":56,"end":67},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T83","span":{"begin":80,"end":85},"obj":"NCBITaxon:10088"},{"id":"T84","span":{"begin":111,"end":135},"obj":"SO_EXT:0000771"},{"id":"T85","span":{"begin":137,"end":140},"obj":"SO_EXT:0000771"},{"id":"T86","span":{"begin":146,"end":151},"obj":"GO:0050909"},{"id":"T87","span":{"begin":178,"end":181},"obj":"SO_EXT:0000771"},{"id":"T88","span":{"begin":205,"end":206},"obj":"CHEBI_SO_EXT:base"},{"id":"T89","span":{"begin":207,"end":229},"obj":"GO_SO_EXT:chromosomal_part_or_position_or_region_or_site"},{"id":"T90","span":{"begin":249,"end":254},"obj":"SO_EXT:0000704"},{"id":"T91","span":{"begin":255,"end":263},"obj":"SO_EXT:sequence_coding_function"},{"id":"T92","span":{"begin":264,"end":268},"obj":"PR_EXT:000036337"},{"id":"T93","span":{"begin":270,"end":276},"obj":"PR_EXT:000036337"},{"id":"T94","span":{"begin":279,"end":285},"obj":"PR_EXT:000036337"},{"id":"T95","span":{"begin":321,"end":334},"obj":"SO_EXT:coding_sequence"},{"id":"T96","span":{"begin":335,"end":366},"obj":"SO_EXT:0000694"},{"id":"T97","span":{"begin":342,"end":352},"obj":"CHEBI_SO_EXT:nucleotide"},{"id":"T98","span":{"begin":368,"end":372},"obj":"SO_EXT:0000694"},{"id":"T99","span":{"begin":428,"end":435},"obj":"CHEBI:15854"},{"id":"T100","span":{"begin":459,"end":466},"obj":"CHEBI:15854"},{"id":"T101","span":{"begin":508,"end":517},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T102","span":{"begin":596,"end":601},"obj":"PR_EXT:000036337"},{"id":"T103","span":{"begin":602,"end":609},"obj":"SO_EXT:0001023"},{"id":"T104","span":{"begin":658,"end":663},"obj":"PR_EXT:000036337"},{"id":"T105","span":{"begin":664,"end":671},"obj":"SO_EXT:0001023"},{"id":"T106","span":{"begin":732,"end":739},"obj":"SO_EXT:0001023"},{"id":"T107","span":{"begin":758,"end":763},"obj":"PR_EXT:000036337"},{"id":"T108","span":{"begin":790,"end":799},"obj":"SO_EXT:0001024"},{"id":"T109","span":{"begin":821,"end":828},"obj":"CHEBI:15854"},{"id":"T110","span":{"begin":829,"end":835},"obj":"GO_EXT:taster"}],"text":"We used brief-access behavioral taste testing of BXD/Ty recombinant inbred (RI) mouse strains to map the major quantitative trait locus (QTL) for taste sensitivity to QHCl. This QTL is restricted to a ~5 Mb interval on chromosome 6 that includes 24 genes encoding T2Rs (Tas2rs). Tas2rs at this locus display in total 307 coding region single nucleotide polymorphisms (SNPs) between the two BXD/Ty RI parental strains, C57BL/6J (quinine-sensitive) and DBA/2J (quinine insensitive); approximately 50% of these mutations are silent. Individual RI lines contain exclusively either C57BL/6J or DBA/2J Tas2r alleles at this locus, and RI lines containing C57BL/6J Tas2r alleles are more sensitive to QHCl than are lines containing DBA/2J alleles. Thus, the entire Tas2r cluster comprises a large haplotype that correlates with quinine taster status."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T21","span":{"begin":32,"end":37},"obj":"GO:0050909"},{"id":"T22","span":{"begin":80,"end":85},"obj":"NCBITaxon:10088"},{"id":"T23","span":{"begin":111,"end":135},"obj":"SO:0000771"},{"id":"T24","span":{"begin":137,"end":140},"obj":"SO:0000771"},{"id":"T25","span":{"begin":146,"end":151},"obj":"GO:0050909"},{"id":"T26","span":{"begin":178,"end":181},"obj":"SO:0000771"},{"id":"T27","span":{"begin":249,"end":254},"obj":"SO:0000704"},{"id":"T28","span":{"begin":264,"end":268},"obj":"PR:000036337"},{"id":"T29","span":{"begin":270,"end":276},"obj":"PR:000036337"},{"id":"T30","span":{"begin":279,"end":285},"obj":"PR:000036337"},{"id":"T31","span":{"begin":335,"end":366},"obj":"SO:0000694"},{"id":"T32","span":{"begin":368,"end":372},"obj":"SO:0000694"},{"id":"T33","span":{"begin":428,"end":435},"obj":"CHEBI:15854"},{"id":"T34","span":{"begin":459,"end":466},"obj":"CHEBI:15854"},{"id":"T35","span":{"begin":596,"end":601},"obj":"PR:000036337"},{"id":"T36","span":{"begin":602,"end":609},"obj":"SO:0001023"},{"id":"T37","span":{"begin":658,"end":663},"obj":"PR:000036337"},{"id":"T38","span":{"begin":664,"end":671},"obj":"SO:0001023"},{"id":"T39","span":{"begin":732,"end":739},"obj":"SO:0001023"},{"id":"T40","span":{"begin":758,"end":763},"obj":"PR:000036337"},{"id":"T41","span":{"begin":790,"end":799},"obj":"SO:0001024"},{"id":"T42","span":{"begin":821,"end":828},"obj":"CHEBI:15854"}],"text":"We used brief-access behavioral taste testing of BXD/Ty recombinant inbred (RI) mouse strains to map the major quantitative trait locus (QTL) for taste sensitivity to QHCl. This QTL is restricted to a ~5 Mb interval on chromosome 6 that includes 24 genes encoding T2Rs (Tas2rs). Tas2rs at this locus display in total 307 coding region single nucleotide polymorphisms (SNPs) between the two BXD/Ty RI parental strains, C57BL/6J (quinine-sensitive) and DBA/2J (quinine insensitive); approximately 50% of these mutations are silent. Individual RI lines contain exclusively either C57BL/6J or DBA/2J Tas2r alleles at this locus, and RI lines containing C57BL/6J Tas2r alleles are more sensitive to QHCl than are lines containing DBA/2J alleles. Thus, the entire Tas2r cluster comprises a large haplotype that correlates with quinine taster status."}