Id |
Subject |
Object |
Predicate |
Lexical cue |
T7341 |
5183-5184 |
. |
denotes |
. |
T7340 |
5179-5183 |
NN |
denotes |
QHCL |
T7339 |
5176-5178 |
NN |
denotes |
mM |
T7338 |
5174-5175 |
CD |
denotes |
1 |
T7337 |
5171-5173 |
IN |
denotes |
to |
T7336 |
5161-5170 |
JJ |
denotes |
sensitive |
T7335 |
5156-5160 |
RBS |
denotes |
most |
T7334 |
5153-5155 |
IN |
denotes |
to |
T7333 |
5147-5152 |
RBS |
denotes |
least |
T7332 |
5142-5146 |
IN |
denotes |
from |
T7331 |
5136-5141 |
NN |
denotes |
order |
T7330 |
5133-5135 |
IN |
denotes |
in |
T7329 |
5122-5125 |
VBP |
denotes |
are |
T7328 |
5126-5132 |
VBN |
denotes |
listed |
T7327 |
5110-5113 |
NN |
denotes |
BXD |
T7326 |
5114-5121 |
NNS |
denotes |
strains |
T7325 |
5106-5109 |
DT |
denotes |
The |
T7324 |
5105-5184 |
sentence |
denotes |
The BXD strains are listed in order from least to most sensitive to 1 mM QHCL. |
T7323 |
5104-5105 |
. |
denotes |
. |
T7322 |
5103-5104 |
-RRB- |
denotes |
) |
T7321 |
5092-5097 |
JJ |
denotes |
right |
T7320 |
5090-5092 |
, |
denotes |
, |
T7319 |
5085-5090 |
NNS |
denotes |
lines |
T7318 |
5081-5084 |
JJ |
denotes |
red |
T7317 |
5098-5103 |
NN |
denotes |
panel |
T7316 |
5080-5081 |
-LRB- |
denotes |
( |
T7315 |
5064-5069 |
NN |
denotes |
Tas2r |
T7314 |
5061-5063 |
NN |
denotes |
D2 |
T7313 |
5070-5079 |
NN |
denotes |
haplotype |
T7312 |
5057-5060 |
DT |
denotes |
the |
T7311 |
5052-5056 |
IN |
denotes |
with |
T7310 |
5044-5051 |
NNS |
denotes |
strains |
T7309 |
5040-5043 |
NN |
denotes |
BXD |
T7308 |
5036-5039 |
VBP |
denotes |
are |
T7307 |
5031-5035 |
IN |
denotes |
than |
T7306 |
5026-5030 |
NN |
denotes |
QHCl |
T7305 |
5023-5025 |
IN |
denotes |
to |
T7304 |
5013-5022 |
JJ |
denotes |
sensitive |
T7303 |
5008-5012 |
RBR |
denotes |
more |
T7302 |
5002-5003 |
-RRB- |
denotes |
) |
T7301 |
4991-4996 |
JJ |
denotes |
right |
T7300 |
4989-4991 |
, |
denotes |
, |
T7299 |
4984-4989 |
NNS |
denotes |
lines |
T7298 |
4979-4983 |
JJ |
denotes |
blue |
T7297 |
4997-5002 |
NN |
denotes |
panel |
T7296 |
4978-4979 |
-LRB- |
denotes |
( |
T7295 |
4962-4967 |
NN |
denotes |
Tas2r |
T7294 |
4959-4961 |
NN |
denotes |
B6 |
T7293 |
4968-4977 |
NN |
denotes |
haplotype |
T7292 |
4955-4958 |
DT |
denotes |
the |
T7291 |
4950-4954 |
IN |
denotes |
with |
T7290 |
4942-4949 |
NNS |
denotes |
strains |
T7289 |
4938-4941 |
NN |
denotes |
BXD |
T7288 |
4936-4938 |
, |
denotes |
, |
T7287 |
5004-5007 |
VBP |
denotes |
are |
T7286 |
4927-4936 |
RB |
denotes |
Similarly |
T7285 |
4926-5105 |
sentence |
denotes |
Similarly, BXD strains with the B6 Tas2r haplotype (blue lines, right panel) are more sensitive to QHCl than are BXD strains with the D2 Tas2r haplotype (red lines, right panel). |
T7284 |
4925-4926 |
. |
denotes |
. |
T7283 |
4914-4919 |
NN |
denotes |
taste |
T7282 |
4920-4925 |
NNS |
denotes |
tests |
T7281 |
4907-4913 |
NN |
denotes |
access |
T7280 |
4901-4906 |
JJ |
denotes |
brief |
T7279 |
4898-4900 |
IN |
denotes |
in |
T7278 |
4896-4897 |
-RRB- |
denotes |
) |
T7277 |
4891-4896 |
NN |
denotes |
panel |
T7276 |
4886-4890 |
JJ |
denotes |
left |
T7275 |
4883-4885 |
IN |
denotes |
on |
T7274 |
4874-4877 |
JJ |
denotes |
red |
T7273 |
4878-4882 |
NN |
denotes |
line |
T7272 |
4873-4874 |
-LRB- |
denotes |
( |
T7271 |
4868-4872 |
NNS |
denotes |
mice |
T7270 |
4865-4867 |
NN |
denotes |
D2 |
T7262 |
4837-4838 |
CD |
denotes |
1 |
T7261 |
4834-4836 |
IN |
denotes |
to |
T7260 |
4824-4833 |
JJ |
denotes |
sensitive |
T7259 |
4819-4823 |
RBR |
denotes |
more |
T7258 |
4813-4814 |
-RRB- |
denotes |
) |
T7257 |
4808-4813 |
NN |
denotes |
panel |
T7256 |
4803-4807 |
JJ |
denotes |
left |
T7255 |
4800-4802 |
IN |
denotes |
on |
T7254 |
4790-4794 |
JJ |
denotes |
blue |
T7253 |
4795-4799 |
NN |
denotes |
line |
T7252 |
4789-4790 |
-LRB- |
denotes |
( |
T7251 |
4815-4818 |
VBP |
denotes |
are |
T7250 |
4784-4788 |
NNS |
denotes |
mice |
T7249 |
4781-4783 |
NN |
denotes |
B6 |
T7248 |
4780-4926 |
sentence |
denotes |
B6 mice (blue line on left panel) are more sensitive to 1 mM and 3 mM QHCl than are D2 mice (red line on left panel) in brief access taste tests. |
T7247 |
4779-4780 |
. |
denotes |
. |
T7246 |
4778-4779 |
-RRB- |
denotes |
) |
T7245 |
4773-4774 |
SYM |
denotes |
= |
T7244 |
4763-4772 |
NN |
denotes |
haplotype |
T7243 |
4760-4762 |
NN |
denotes |
D2 |
T7242 |
4758-4760 |
, |
denotes |
, |
T7241 |
4752-4753 |
SYM |
denotes |
= |
T7240 |
4754-4758 |
JJ |
denotes |
blue |
T7239 |
4742-4751 |
NN |
denotes |
haplotype |
T7238 |
4739-4741 |
NN |
denotes |
B6 |
T7237 |
4775-4778 |
JJ |
denotes |
red |
T7236 |
4738-4739 |
-LRB- |
denotes |
( |
T7235 |
4728-4737 |
NN |
denotes |
haplotype |
T7234 |
4722-4727 |
NN |
denotes |
Tas2r |
T7233 |
4719-4721 |
IN |
denotes |
on |
T7232 |
4713-4718 |
VBN |
denotes |
based |
T7231 |
4701-4704 |
VBP |
denotes |
are |
T7230 |
4699-4700 |
CD |
denotes |
1 |
T7229 |
4692-4698 |
NN |
denotes |
Figure |
T7228 |
4689-4691 |
IN |
denotes |
in |
T7227 |
4680-4688 |
VBN |
denotes |
reported |
T7226 |
4668-4671 |
NN |
denotes |
BXD |
T7225 |
4664-4667 |
CC |
denotes |
and |
T7224 |
4661-4663 |
NN |
denotes |
D2 |
T7223 |
4659-4661 |
, |
denotes |
, |
T7222 |
4672-4679 |
NNS |
denotes |
strains |
T7221 |
4657-4659 |
NN |
denotes |
B6 |
T7220 |
4654-4656 |
IN |
denotes |
of |
T7219 |
4705-4712 |
VBN |
denotes |
grouped |
T7218 |
4642-4646 |
NN |
denotes |
lick |
T7217 |
4647-4653 |
NNS |
denotes |
ratios |
T7216 |
4637-4641 |
NN |
denotes |
Mean |
T7215 |
4636-4780 |
sentence |
denotes |
Mean lick ratios of B6, D2 and BXD strains reported in Figure 1 are grouped based on Tas2r haplotype (B6 haplotype = blue, D2 haplotype = red). |
T7214 |
4635-4636 |
. |
denotes |
. |
T7213 |
4626-4635 |
NN |
denotes |
phenotype |
T7212 |
4620-4625 |
NN |
denotes |
taste |
T7211 |
4615-4619 |
NN |
denotes |
QHCl |
T7210 |
4610-4614 |
IN |
denotes |
with |
T7209 |
4599-4609 |
VBZ |
denotes |
correlates |
T7208 |
4590-4598 |
NN |
denotes |
genotype |
T7207 |
4584-4589 |
NN |
denotes |
Tas2r |
T7179 |
4572-4573 |
. |
denotes |
. |
T7178 |
4571-4572 |
-RRB- |
denotes |
) |
T7177 |
4570-4571 |
SYM |
denotes |
* |
T7176 |
4569-4570 |
-LRB- |
denotes |
( |
T7175 |
4555-4558 |
VBP |
denotes |
are |
T7174 |
4549-4554 |
NN |
denotes |
study |
T7173 |
4544-4548 |
DT |
denotes |
this |
T7172 |
4541-4543 |
IN |
denotes |
in |
T7171 |
4521-4533 |
RB |
denotes |
behaviorally |
T7170 |
4516-4520 |
VBD |
denotes |
were |
T7169 |
4534-4540 |
VBN |
denotes |
tested |
T7168 |
4511-4515 |
WDT |
denotes |
that |
T7167 |
4559-4568 |
VBN |
denotes |
indicated |
T7166 |
4499-4502 |
NN |
denotes |
BXD |
T7165 |
4496-4498 |
CD |
denotes |
17 |
T7164 |
4503-4510 |
NNS |
denotes |
strains |
T7163 |
4492-4495 |
DT |
denotes |
The |
T7162 |
4491-4573 |
sentence |
denotes |
The 17 BXD strains that were behaviorally tested in this study are indicated (*). |
T7161 |
4490-4491 |
. |
denotes |
. |
T7160 |
4489-4490 |
-RRB- |
denotes |
) |
T7159 |
4482-4483 |
SYM |
denotes |
= |
T7158 |
4475-4481 |
NN |
denotes |
allele |
T7157 |
4472-4474 |
NN |
denotes |
D2 |
T7156 |
4470-4472 |
, |
denotes |
, |
T7155 |
4464-4465 |
SYM |
denotes |
= |
T7154 |
4466-4470 |
NN |
denotes |
gray |
T7153 |
4457-4463 |
NN |
denotes |
allele |
T7152 |
4454-4456 |
NN |
denotes |
B6 |
T7151 |
4484-4489 |
JJ |
denotes |
white |
T7150 |
4453-4454 |
-LRB- |
denotes |
( |
T7149 |
4437-4445 |
JJ |
denotes |
parental |
T7148 |
4432-4436 |
JJ |
denotes |
same |
T7147 |
4446-4452 |
NN |
denotes |
strain |
T7146 |
4428-4431 |
DT |
denotes |
the |
T7145 |
4423-4427 |
IN |
denotes |
from |
T7144 |
4401-4404 |
NN |
denotes |
BXD |
T7143 |
4390-4400 |
JJ |
denotes |
individual |
T7142 |
4405-4411 |
NN |
denotes |
strain |
T7141 |
4387-4389 |
DT |
denotes |
an |
T7140 |
4380-4386 |
IN |
denotes |
within |
T7139 |
4412-4422 |
VBD |
denotes |
originated |
T7138 |
4374-4379 |
NN |
denotes |
Tas2r |
T7137 |
4369-4373 |
DT |
denotes |
Each |
T7136 |
4368-4491 |
sentence |
denotes |
Each Tas2r within an individual BXD strain originated from the same parental strain (B6 allele = gray, D2 allele = white). |
T7135 |
4367-4368 |
. |
denotes |
. |
T7134 |
4357-4359 |
JJ |
denotes |
RI |
T7133 |
4353-4354 |
HYPH |
denotes |
/ |
T7132 |
4354-4356 |
NN |
denotes |
Ty |
T7131 |
4350-4353 |
NN |
denotes |
BXD |
T7130 |
4360-4367 |
NNS |
denotes |
strains |
T7129 |
4347-4349 |
CD |
denotes |
29 |
T7128 |
4342-4346 |
IN |
denotes |
from |
T7127 |
4330-4337 |
JJ |
denotes |
genomic |
T7126 |
4338-4341 |
NN |
denotes |
DNA |
T7125 |
4320-4329 |
VBN |
denotes |
amplified |
T7124 |
4306-4307 |
CD |
denotes |
6 |
T7123 |
4295-4305 |
NN |
denotes |
chromosome |
T7122 |
4288-4294 |
JJ |
denotes |
distal |
T7121 |
4308-4315 |
NN |
denotes |
cluster |
T7120 |
4284-4287 |
DT |
denotes |
the |
T7119 |
4281-4283 |
IN |
denotes |
in |
T7118 |
4274-4280 |
NNS |
denotes |
Tas2rs |
T7117 |
4271-4273 |
CD |
denotes |
21 |
T7116 |
4268-4270 |
IN |
denotes |
of |
T7115 |
4263-4267 |
DT |
denotes |
each |
T7114 |
4260-4262 |
IN |
denotes |
of |
T7113 |
4316-4319 |
VBD |
denotes |
was |
T7112 |
4248-4254 |
VBG |
denotes |
coding |
T7111 |
4255-4259 |
NN |
denotes |
exon |
T7110 |
4244-4247 |
DT |
denotes |
The |
T7109 |
4243-4368 |
sentence |
denotes |
The coding exon of each of 21 Tas2rs in the distal chromosome 6 cluster was amplified genomic DNA from 29 BXD/Ty RI strains. |
T7108 |
4242-4243 |
. |
denotes |
. |
T7107 |
4235-4237 |
JJ |
denotes |
RI |
T7106 |
4238-4242 |
NNS |
denotes |
mice |
T7105 |
4231-4232 |
HYPH |
denotes |
/ |
T7104 |
4232-4234 |
NN |
denotes |
Ty |
T7103 |
4228-4231 |
NN |
denotes |
BXD |
T7102 |
4225-4227 |
IN |
denotes |
in |
T7101 |
4208-4214 |
JJ |
denotes |
single |
T7100 |
4215-4224 |
NN |
denotes |
haplotype |
T7099 |
4206-4207 |
DT |
denotes |
a |
T7098 |
4203-4205 |
VBZ |
denotes |
is |
T7097 |
4189-4194 |
NN |
denotes |
Tas2r |
T7096 |
4195-4202 |
NN |
denotes |
cluster |
T7095 |
4185-4188 |
DT |
denotes |
The |
T7073 |
2804-2805 |
. |
denotes |
. |
T7072 |
2788-2804 |
NNS |
denotes |
oligonucleotides |
T7071 |
2784-2787 |
CC |
denotes |
and |
T7070 |
2776-2783 |
NNS |
denotes |
enzymes |
T7069 |
2764-2775 |
NN |
denotes |
restriction |
T7068 |
2760-2763 |
IN |
denotes |
for |
T7067 |
2758-2759 |
CD |
denotes |
3 |
T7066 |
2752-2757 |
NN |
denotes |
Table |
T7065 |
2750-2752 |
: |
denotes |
: |
T7064 |
2749-2750 |
CD |
denotes |
1 |
T7063 |
2744-2748 |
NN |
denotes |
file |
T7062 |
2733-2743 |
JJ |
denotes |
additional |
T7061 |
2729-2732 |
VB |
denotes |
See |
T7060 |
2728-2805 |
sentence |
denotes |
See additional file 1: Table 3 for restriction enzymes and oligonucleotides. |
T7059 |
2727-2728 |
. |
denotes |
. |
T7058 |
2726-2727 |
-RRB- |
denotes |
) |
T7057 |
2710-2716 |
NN |
denotes |
taster |
T7056 |
2707-2709 |
NN |
denotes |
D2 |
T7055 |
2705-2706 |
SYM |
denotes |
= |
T7054 |
2701-2704 |
NN |
denotes |
red |
T7053 |
2699-2701 |
, |
denotes |
, |
T7052 |
2683-2689 |
NN |
denotes |
taster |
T7051 |
2680-2682 |
NN |
denotes |
B6 |
T7050 |
2678-2679 |
SYM |
denotes |
= |
T7049 |
2690-2699 |
NN |
denotes |
phenotype |
T7048 |
2673-2677 |
NN |
denotes |
blue |
T7047 |
2717-2726 |
NN |
denotes |
phenotype |
T7269 |
4861-4864 |
VBP |
denotes |
are |
T7268 |
4856-4860 |
IN |
denotes |
than |
T7267 |
4848-4850 |
NN |
denotes |
mM |
T7266 |
4846-4847 |
CD |
denotes |
3 |
T7265 |
4842-4845 |
CC |
denotes |
and |
T7264 |
4851-4855 |
NN |
denotes |
QHCl |
T7263 |
4839-4841 |
NN |
denotes |
mM |
T7046 |
2672-2673 |
-LRB- |
denotes |
( |
T7045 |
2662-2671 |
NN |
denotes |
phenotype |
T7044 |
2655-2661 |
NN |
denotes |
taster |
T7043 |
2650-2654 |
NN |
denotes |
QHCl |
T7042 |
2645-2649 |
IN |
denotes |
with |
T7041 |
2627-2633 |
RB |
denotes |
always |
T7040 |
2623-2626 |
VBD |
denotes |
was |
T7039 |
2614-2622 |
NN |
denotes |
genotype |
T7038 |
2608-2613 |
NN |
denotes |
Tas2r |
T7037 |
2606-2608 |
, |
denotes |
, |
T7036 |
2600-2606 |
VBN |
denotes |
tested |
T7035 |
2588-2591 |
NN |
denotes |
BXD |
T7034 |
2585-2587 |
CD |
denotes |
17 |
T7033 |
2592-2599 |
NNS |
denotes |
strains |
T7032 |
2581-2584 |
DT |
denotes |
the |
T7031 |
2578-2580 |
IN |
denotes |
of |
T7030 |
2573-2577 |
DT |
denotes |
each |
T7029 |
2634-2644 |
VBN |
denotes |
correlated |
T7028 |
2570-2572 |
IN |
denotes |
In |
T7027 |
2569-2728 |
sentence |
denotes |
In each of the 17 BXD strains tested, Tas2r genotype was always correlated with QHCl taster phenotype (blue = B6 taster phenotype, red = D2 taster phenotype). |
T7026 |
2568-2569 |
. |
denotes |
. |
T7025 |
2567-2568 |
-RRB- |
denotes |
) |
T7024 |
2559-2567 |
NN |
denotes |
Tas2r120 |
T7023 |
2558-2559 |
-LRB- |
denotes |
( |
T7022 |
2546-2549 |
NN |
denotes |
PCR |
T7021 |
2550-2557 |
NN |
denotes |
product |
T7020 |
2544-2545 |
DT |
denotes |
a |
T7019 |
2541-2543 |
IN |
denotes |
of |
T7018 |
2533-2540 |
NN |
denotes |
absence |
T7017 |
2530-2532 |
CC |
denotes |
or |
T7016 |
2521-2529 |
NN |
denotes |
presence |
T7015 |
2517-2520 |
DT |
denotes |
the |
T7014 |
2514-2516 |
IN |
denotes |
on |
T7013 |
2511-2513 |
CC |
denotes |
or |
T7012 |
2509-2510 |
-RRB- |
denotes |
) |
T7011 |
2501-2509 |
NN |
denotes |
Tas2r131 |
T7010 |
2497-2500 |
CC |
denotes |
and |
T7009 |
2488-2496 |
NN |
denotes |
Tas2r116 |
T7008 |
2486-2488 |
, |
denotes |
, |
T7007 |
2478-2486 |
NN |
denotes |
Tas2r105 |
T7006 |
2477-2478 |
-LRB- |
denotes |
( |
T7005 |
2464-2467 |
NN |
denotes |
PCR |
T7004 |
2468-2476 |
NNS |
denotes |
products |
T7003 |
2454-2463 |
VBN |
denotes |
amplified |
T7002 |
2451-2453 |
IN |
denotes |
of |
T7001 |
2431-2442 |
NN |
denotes |
restriction |
T7000 |
2443-2450 |
NNS |
denotes |
digests |
T6999 |
2420-2430 |
JJ |
denotes |
diagnostic |
T6998 |
2417-2419 |
IN |
denotes |
on |
T6997 |
2411-2416 |
VBN |
denotes |
based |
T6996 |
2393-2395 |
VB |
denotes |
be |
T6995 |
2389-2392 |
MD |
denotes |
can |
T6994 |
2382-2388 |
NNS |
denotes |
Tas2rs |
T6993 |
2377-2381 |
CD |
denotes |
four |
T6992 |
2374-2376 |
IN |
denotes |
of |
T6991 |
2396-2410 |
VBN |
denotes |
differentiated |
T6990 |
2363-2365 |
NN |
denotes |
D2 |
T6989 |
2359-2362 |
CC |
denotes |
and |
T6988 |
2366-2373 |
NNS |
denotes |
alleles |
T6987 |
2356-2358 |
NN |
denotes |
B6 |
T6986 |
2355-2569 |
sentence |
denotes |
B6 and D2 alleles of four Tas2rs can be differentiated based on diagnostic restriction digests of amplified PCR products (Tas2r105, Tas2r116 and Tas2r131) or on the presence or absence of a PCR product (Tas2r120). |
T6985 |
2354-2355 |
. |
denotes |
. |
T6984 |
2348-2354 |
NNS |
denotes |
Tas2rs |
T6983 |
2343-2347 |
CD |
denotes |
four |
T6982 |
2339-2342 |
IN |
denotes |
for |
T6981 |
2331-2338 |
NNS |
denotes |
strains |
T6980 |
2324-2330 |
IN |
denotes |
across |
T6979 |
2314-2323 |
NN |
denotes |
variation |
T6978 |
2306-2313 |
JJ |
denotes |
Allelic |
T3406 |
4173-4174 |
. |
denotes |
. |
T3405 |
4167-4173 |
NN |
denotes |
status |
T3404 |
4160-4166 |
NN |
denotes |
taster |
T3403 |
4155-4159 |
NN |
denotes |
QHCl |
T3402 |
4150-4154 |
IN |
denotes |
with |
T3401 |
4143-4149 |
VBZ |
denotes |
varies |
T3400 |
4138-4142 |
WDT |
denotes |
that |
T3399 |
4121-4127 |
JJ |
denotes |
single |
T3398 |
4128-4137 |
NN |
denotes |
haplotype |
T3397 |
4119-4120 |
DT |
denotes |
a |
T3396 |
4102-4107 |
NN |
denotes |
Tas2r |
T3395 |
4095-4101 |
JJ |
denotes |
entire |
T3394 |
4108-4115 |
NN |
denotes |
cluster |
T3393 |
4091-4094 |
DT |
denotes |
the |
T3392 |
4116-4118 |
VBZ |
denotes |
is |
T3391 |
4086-4090 |
IN |
denotes |
that |
T3390 |
4075-4085 |
VBG |
denotes |
suggesting |
T3389 |
4073-4075 |
, |
denotes |
, |
T3388 |
4072-4073 |
-RRB- |
denotes |
) |
T3387 |
4069-4071 |
, |
denotes |
, |
T3386 |
4068-4069 |
CD |
denotes |
6 |
T3385 |
4060-4067 |
NNS |
denotes |
Figures |
T3384 |
4071-4072 |
CD |
denotes |
7 |
T3383 |
4059-4060 |
-LRB- |
denotes |
( |
T3382 |
4043-4048 |
NN |
denotes |
taste |
T3381 |
4038-4042 |
NN |
denotes |
QHCl |
T3380 |
4049-4058 |
NN |
denotes |
phenotype |
T3379 |
4034-4037 |
DT |
denotes |
the |
T3378 |
4029-4033 |
IN |
denotes |
with |
T3377 |
4011-4017 |
RB |
denotes |
always |
T3376 |
4000-4005 |
NN |
denotes |
Tas2r |
T3375 |
4006-4010 |
NN |
denotes |
gene |
T3374 |
3995-3999 |
DT |
denotes |
each |
T3373 |
3992-3994 |
IN |
denotes |
of |
T3372 |
3983-3991 |
NN |
denotes |
genotype |
T3371 |
3979-3982 |
DT |
denotes |
the |
T3370 |
3977-3979 |
, |
denotes |
, |
T3369 |
4018-4028 |
VBD |
denotes |
correlated |
T3368 |
3966-3977 |
RB |
denotes |
Furthermore |
T3367 |
3965-4174 |
sentence |
denotes |
Furthermore, the genotype of each Tas2r gene always correlated with the QHCl taste phenotype (Figures 6, 7), suggesting that the entire Tas2r cluster is a single haplotype that varies with QHCl taster status. |
T3366 |
3964-3965 |
. |
denotes |
. |
T3365 |
3963-3964 |
-RRB- |
denotes |
) |
T3364 |
3960-3962 |
, |
denotes |
, |
T3363 |
3959-3960 |
CD |
denotes |
5 |
T3362 |
3951-3958 |
NNS |
denotes |
Figures |
T3361 |
3962-3963 |
CD |
denotes |
6 |
T3360 |
3950-3951 |
-LRB- |
denotes |
( |
T3359 |
3934-3942 |
JJ |
denotes |
parental |
T3358 |
3929-3933 |
JJ |
denotes |
same |
T3357 |
3943-3949 |
NN |
denotes |
strain |
T3356 |
3925-3928 |
DT |
denotes |
the |
T3355 |
3920-3924 |
IN |
denotes |
from |
T3354 |
3901-3903 |
JJ |
denotes |
RI |
T3353 |
3890-3900 |
JJ |
denotes |
individual |
T3352 |
3904-3908 |
NN |
denotes |
line |
T3351 |
3887-3889 |
DT |
denotes |
an |
T3350 |
3880-3886 |
IN |
denotes |
within |
T3349 |
3874-3879 |
NN |
denotes |
Tas2r |
T3348 |
3868-3873 |
DT |
denotes |
every |
T3347 |
3866-3868 |
, |
denotes |
, |
T3346 |
3860-3866 |
VBN |
denotes |
tested |
T3345 |
3851-3853 |
JJ |
denotes |
RI |
T3344 |
3854-3859 |
NNS |
denotes |
lines |
T3343 |
3847-3850 |
DT |
denotes |
all |
T3342 |
3909-3919 |
VBD |
denotes |
originated |
T3341 |
3843-3846 |
IN |
denotes |
For |
T3340 |
3842-3965 |
sentence |
denotes |
For all RI lines tested, every Tas2r within an individual RI line originated from the same parental strain (Figures 5, 6). |
T3339 |
3841-3842 |
. |
denotes |
. |
T3338 |
3833-3835 |
JJ |
denotes |
RI |
T3337 |
3829-3832 |
NN |
denotes |
BXD |
T3336 |
3836-3841 |
NNS |
denotes |
lines |
T3335 |
3825-3828 |
DT |
denotes |
the |
T3334 |
3822-3824 |
IN |
denotes |
of |
T3333 |
3811-3821 |
NN |
denotes |
generation |
T3332 |
3807-3810 |
DT |
denotes |
the |
T3331 |
3800-3806 |
IN |
denotes |
during |
T3330 |
3790-3791 |
CD |
denotes |
6 |
T3329 |
3779-3789 |
NN |
denotes |
chromosome |
T3328 |
3772-3778 |
JJ |
denotes |
distal |
T3327 |
3792-3799 |
NN |
denotes |
cluster |
T3326 |
3768-3771 |
DT |
denotes |
the |
T3325 |
3761-3767 |
IN |
denotes |
within |
T3324 |
3740-3753 |
NN |
denotes |
recombination |
T3323 |
3731-3739 |
JJ |
denotes |
apparent |
T3322 |
3754-3760 |
NNS |
denotes |
events |
T3321 |
3728-3730 |
DT |
denotes |
no |
T3320 |
3718-3722 |
VBP |
denotes |
have |
T3319 |
3712-3717 |
EX |
denotes |
there |
T3318 |
3723-3727 |
VBN |
denotes |
been |
T3317 |
3707-3711 |
IN |
denotes |
that |
T3316 |
3693-3695 |
PRP |
denotes |
we |
T3315 |
3691-3693 |
, |
denotes |
, |
T3314 |
3696-3706 |
VBD |
denotes |
discovered |
T3313 |
3679-3691 |
RB |
denotes |
Surprisingly |
T3312 |
3678-3842 |
sentence |
denotes |
Surprisingly, we discovered that there have been no apparent recombination events within the distal chromosome 6 cluster during the generation of the BXD RI lines. |
T3311 |
3677-3678 |
. |
denotes |
. |
T3310 |
3673-3677 |
NN |
denotes |
gene |
T3309 |
3668-3672 |
DT |
denotes |
this |
T3308 |
3664-3667 |
IN |
denotes |
for |
T3307 |
3652-3654 |
NN |
denotes |
D2 |
T3306 |
3655-3663 |
NN |
denotes |
genotype |
T3305 |
3648-3651 |
DT |
denotes |
the |
T3304 |
3645-3647 |
IN |
denotes |
of |
T3303 |
3634-3644 |
JJ |
denotes |
diagnostic |
T3302 |
3618-3621 |
NN |
denotes |
PCR |
T3301 |
3622-3629 |
NN |
denotes |
product |
T3300 |
3616-3617 |
DT |
denotes |
a |
T3299 |
3613-3615 |
IN |
denotes |
of |
T3298 |
3605-3612 |
NN |
denotes |
absence |
T3297 |
3601-3604 |
DT |
denotes |
the |
T3296 |
3599-3601 |
, |
denotes |
, |
T3295 |
3595-3599 |
NNS |
denotes |
mice |
T3294 |
3592-3594 |
NN |
denotes |
D2 |
T3293 |
3589-3591 |
IN |
denotes |
in |
T3292 |
3574-3580 |
RB |
denotes |
likely |
T3291 |
3571-3573 |
VBZ |
denotes |
is |
T3290 |
3581-3588 |
VBN |
denotes |
deleted |
T3289 |
3565-3570 |
WDT |
denotes |
which |
T3288 |
3563-3565 |
, |
denotes |
, |
T3287 |
3555-3563 |
NN |
denotes |
Tas2r120 |
T3286 |
3630-3633 |
VBD |
denotes |
was |
T3285 |
3551-3554 |
IN |
denotes |
For |
T3284 |
3550-3678 |
sentence |
denotes |
For Tas2r120, which is likely deleted in D2 mice, the absence of a PCR product was diagnostic of the D2 genotype for this gene. |
T3283 |
3549-3550 |
. |
denotes |
. |
T3282 |
3536-3538 |
VB |
denotes |
be |
T3281 |
3530-3535 |
MD |
denotes |
could |
T3280 |
3505-3516 |
NN |
denotes |
restriction |
T3260 |
3418-3419 |
. |
denotes |
. |
T3259 |
3409-3411 |
NN |
denotes |
D2 |
T3258 |
3406-3408 |
CC |
denotes |
or |
T3257 |
3403-3405 |
NN |
denotes |
B6 |
T3256 |
3412-3418 |
NN |
denotes |
allele |
T3255 |
3401-3402 |
DT |
denotes |
a |
T3254 |
3396-3400 |
IN |
denotes |
from |
T3253 |
3382-3385 |
VBD |
denotes |
was |
T3252 |
3370-3373 |
NN |
denotes |
PCR |
T3251 |
3364-3369 |
NN |
denotes |
Tas2r |
T3250 |
3353-3363 |
JJ |
denotes |
particular |
T3249 |
3374-3381 |
NN |
denotes |
product |
T3248 |
3351-3352 |
DT |
denotes |
a |
T3247 |
3386-3395 |
VBN |
denotes |
amplified |
T3246 |
3343-3350 |
IN |
denotes |
whether |
T3245 |
3326-3333 |
RB |
denotes |
quickly |
T3244 |
3323-3325 |
TO |
denotes |
to |
T3243 |
3334-3342 |
VB |
denotes |
identify |
T3242 |
3320-3322 |
PRP |
denotes |
us |
T3241 |
3308-3313 |
MD |
denotes |
would |
T3240 |
3314-3319 |
VB |
denotes |
allow |
T3239 |
3303-3307 |
WDT |
denotes |
that |
T3238 |
3282-3294 |
NN |
denotes |
endonuclease |
T3237 |
3270-3281 |
NN |
denotes |
restriction |
T3236 |
3295-3302 |
NNS |
denotes |
digests |
T3235 |
3259-3269 |
JJ |
denotes |
diagnostic |
T3234 |
3250-3258 |
VB |
denotes |
identify |
T3233 |
3247-3249 |
TO |
denotes |
to |
T3232 |
3242-3246 |
JJ |
denotes |
able |
T3231 |
3234-3236 |
PRP |
denotes |
we |
T3230 |
3232-3234 |
, |
denotes |
, |
T3229 |
3227-3232 |
NNS |
denotes |
cases |
T3228 |
3222-3226 |
JJS |
denotes |
most |
T3227 |
3237-3241 |
VBD |
denotes |
were |
T3226 |
3219-3221 |
IN |
denotes |
In |
T3225 |
3218-3419 |
sentence |
denotes |
In most cases, we were able to identify diagnostic restriction endonuclease digests that would allow us to quickly identify whether a particular Tas2r PCR product was amplified from a B6 or D2 allele. |
T3224 |
3217-3218 |
. |
denotes |
. |
T3223 |
3208-3217 |
VBD |
denotes |
contained |
T3222 |
3203-3207 |
PRP |
denotes |
they |
T3221 |
3195-3202 |
VBZ |
denotes |
alleles |
T3220 |
3189-3194 |
NN |
denotes |
Tas2r |
T3219 |
3185-3188 |
DT |
denotes |
the |
T3218 |
3181-3184 |
IN |
denotes |
for |
T3217 |
3179-3181 |
, |
denotes |
, |
T3216 |
3172-3179 |
NN |
denotes |
testing |
T3215 |
3166-3171 |
NN |
denotes |
taste |
T3214 |
3163-3165 |
IN |
denotes |
in |
T3213 |
3154-3157 |
VBD |
denotes |
had |
T3212 |
3151-3153 |
PRP |
denotes |
we |
T3211 |
3158-3162 |
VBN |
denotes |
used |
T3210 |
3146-3150 |
WDT |
denotes |
that |
T3209 |
3143-3145 |
CD |
denotes |
17 |
T3208 |
3139-3142 |
DT |
denotes |
the |
T3207 |
3129-3138 |
VBG |
denotes |
including |
T3206 |
3127-3129 |
, |
denotes |
, |
T3205 |
3119-3121 |
JJ |
denotes |
RI |
T3204 |
3115-3118 |
NN |
denotes |
BXD |
T3203 |
3105-3114 |
JJ |
denotes |
available |
T3202 |
3122-3127 |
NNS |
denotes |
lines |
T3201 |
3102-3104 |
CD |
denotes |
29 |
T3200 |
3097-3101 |
IN |
denotes |
from |
T3199 |
3093-3096 |
NN |
denotes |
DNA |
T3198 |
3085-3092 |
JJ |
denotes |
genomic |
T3197 |
3078-3084 |
VB |
denotes |
screen |
T3196 |
3075-3077 |
TO |
denotes |
to |
T3195 |
3062-3064 |
PRP |
denotes |
we |
T3194 |
3060-3062 |
, |
denotes |
, |
T3193 |
3065-3074 |
VBD |
denotes |
proceeded |
T3192 |
3051-3060 |
RB |
denotes |
Therefore |
T3191 |
3050-3218 |
sentence |
denotes |
Therefore, we proceeded to screen genomic DNA from 29 available BXD RI lines, including the 17 that we had used in taste testing, for the Tas2r alleles they contained. |
T3190 |
3049-3050 |
. |
denotes |
. |
T3189 |
3038-3049 |
NN |
denotes |
sensitivity |
T3188 |
3032-3037 |
NN |
denotes |
taste |
T3187 |
3027-3031 |
NN |
denotes |
QHCl |
T3186 |
3022-3026 |
IN |
denotes |
with |
T3185 |
3007-3010 |
VBP |
denotes |
are |
T3184 |
3011-3021 |
VBN |
denotes |
correlated |
T3183 |
2993-2998 |
NN |
denotes |
Tas2r |
T3182 |
2999-3006 |
NNS |
denotes |
alleles |
T3181 |
2987-2992 |
WDT |
denotes |
which |
T3180 |
2975-2986 |
VBG |
denotes |
determining |
T3179 |
2972-2974 |
IN |
denotes |
by |
T3178 |
2962-2967 |
NN |
denotes |
taste |
T3177 |
2957-2961 |
NN |
denotes |
QHCl |
T3176 |
2968-2971 |
NN |
denotes |
QTL |
T3175 |
2953-2956 |
DT |
denotes |
the |
T3174 |
2950-2952 |
IN |
denotes |
of |
T3173 |
2930-2938 |
JJ |
denotes |
physical |
T3172 |
2939-2949 |
NNS |
denotes |
boundaries |
T3171 |
2926-2929 |
DT |
denotes |
the |
T3170 |
2919-2925 |
VB |
denotes |
narrow |
T3169 |
2916-2918 |
TO |
denotes |
to |
T3168 |
2907-2915 |
JJ |
denotes |
possible |
T3167 |
2898-2903 |
MD |
denotes |
might |
T3166 |
2895-2897 |
PRP |
denotes |
it |
T3165 |
2904-2906 |
VB |
denotes |
be |
T3164 |
2890-2894 |
IN |
denotes |
that |
T3163 |
2865-2871 |
JJ |
denotes |
inbred |
T3162 |
2861-2864 |
CD |
denotes |
two |
T3161 |
2872-2879 |
NNS |
denotes |
strains |
T3160 |
2855-2860 |
DT |
denotes |
these |
T3159 |
2852-2854 |
IN |
denotes |
in |
T3158 |
2842-2851 |
NNS |
denotes |
receptors |
T3157 |
2830-2841 |
JJ |
denotes |
orthologous |
T3156 |
2822-2829 |
IN |
denotes |
between |
T3155 |
2880-2889 |
VBD |
denotes |
suggested |
T3144 |
2279-2283 |
NNS |
denotes |
data |
T3143 |
2288-2293 |
VBN |
denotes |
shown |
T3142 |
2278-2279 |
-LRB- |
denotes |
( |
T3141 |
2273-2277 |
NNS |
denotes |
T2Rs |
T3140 |
2269-2272 |
DT |
denotes |
the |
T3139 |
2266-2268 |
IN |
denotes |
of |
T3138 |
2246-2259 |
JJ |
denotes |
extracellular |
T3137 |
2242-2245 |
CD |
denotes |
two |
T3136 |
2236-2241 |
JJ |
denotes |
first |
T3135 |
2260-2265 |
NNS |
denotes |
loops |
T3134 |
2232-2235 |
DT |
denotes |
the |
T3133 |
2225-2231 |
IN |
denotes |
within |
T3132 |
2216-2220 |
VBN |
denotes |
seen |
T3131 |
2203-2207 |
NN |
denotes |
acid |
T3130 |
2197-2202 |
NN |
denotes |
amino |
T3129 |
2208-2215 |
NNS |
denotes |
changes |
T3128 |
2193-2196 |
DT |
denotes |
the |
T3127 |
2190-2192 |
IN |
denotes |
of |
T3126 |
2188-2189 |
NN |
denotes |
% |
T3125 |
2186-2188 |
CD |
denotes |
23 |
T3124 |
2184-2186 |
, |
denotes |
, |
T3123 |
2175-2184 |
NNS |
denotes |
receptors |
T3122 |
2171-2174 |
DT |
denotes |
the |
T3121 |
2168-2170 |
IN |
denotes |
of |
T3120 |
2160-2167 |
NNS |
denotes |
regions |
T3119 |
2156-2159 |
DT |
denotes |
all |
T3118 |
2153-2155 |
IN |
denotes |
in |
T3117 |
2221-2224 |
VBP |
denotes |
are |
T3116 |
2143-2146 |
VBP |
denotes |
are |
T3115 |
2133-2135 |
NN |
denotes |
D2 |
T3114 |
2129-2132 |
CC |
denotes |
and |
T3113 |
2136-2142 |
NNS |
denotes |
Tas2rs |
T3112 |
2126-2128 |
NN |
denotes |
B6 |
T3111 |
2118-2125 |
IN |
denotes |
between |
T3110 |
2109-2117 |
NNS |
denotes |
residues |
T3109 |
2097-2108 |
JJ |
denotes |
polymorphic |
T3108 |
2147-2152 |
VBN |
denotes |
found |
T3107 |
2088-2096 |
IN |
denotes |
Although |
T3106 |
2087-2295 |
sentence |
denotes |
Although polymorphic residues between B6 and D2 Tas2rs are found in all regions of the receptors, 23% of the amino acid changes seen are within the first two extracellular loops of the T2Rs (data not shown). |
T3105 |
2086-2087 |
. |
denotes |
. |
T3104 |
2085-2086 |
-RRB- |
denotes |
) |
T3103 |
2076-2079 |
RB |
denotes |
not |
T3102 |
2071-2075 |
NNS |
denotes |
data |
T3101 |
2080-2085 |
VBN |
denotes |
shown |
T3100 |
2070-2071 |
-LRB- |
denotes |
( |
T3099 |
2064-2069 |
NNS |
denotes |
exons |
T3098 |
2057-2063 |
NN |
denotes |
coding |
T3097 |
2050-2056 |
IN |
denotes |
within |
T3096 |
2042-2049 |
JJ |
denotes |
present |
T3095 |
2038-2041 |
VBP |
denotes |
are |
T3094 |
2013-2023 |
NN |
denotes |
nucleotide |
T3093 |
2006-2012 |
JJ |
denotes |
single |
T3092 |
2024-2037 |
NNS |
denotes |
polymorphisms |
T3091 |
2002-2005 |
CD |
denotes |
307 |
T3090 |
1998-2001 |
CC |
denotes |
and |
T3089 |
1996-1998 |
, |
denotes |
, |
T3088 |
1989-1991 |
NN |
denotes |
D2 |
T3087 |
1985-1988 |
CC |
denotes |
and |
T3086 |
1992-1996 |
NNS |
denotes |
mice |
T3085 |
1982-1984 |
NN |
denotes |
B6 |
T3084 |
1979-1981 |
IN |
denotes |
in |
T3083 |
1971-1978 |
NNS |
denotes |
alleles |
T3082 |
1961-1970 |
JJ |
denotes |
different |
T3081 |
1947-1955 |
VBN |
denotes |
examined |
T3080 |
1956-1960 |
VBP |
denotes |
have |
T3079 |
1937-1939 |
CD |
denotes |
24 |
T3078 |
1940-1946 |
NNS |
denotes |
Tas2rs |
T3077 |
1933-1936 |
DT |
denotes |
All |
T3076 |
1932-2087 |
sentence |
denotes |
All 24 Tas2rs examined have different alleles in B6 and D2 mice, and 307 single nucleotide polymorphisms are present within coding exons (data not shown). |
T3075 |
1931-1932 |
. |
denotes |
. |
T3074 |
1913-1921 |
NN |
denotes |
missense |
T3073 |
1910-1912 |
CD |
denotes |
16 |
T3072 |
1906-1909 |
CC |
denotes |
and |
T3071 |
1922-1931 |
NNS |
denotes |
mutations |
T3070 |
1902-1905 |
CD |
denotes |
one |
T3069 |
1894-1901 |
IN |
denotes |
between |
T3068 |
1884-1893 |
VBD |
denotes |
contained |
T3067 |
1874-1876 |
CD |
denotes |
19 |
T3066 |
1864-1873 |
VBG |
denotes |
remaining |
T3065 |
1877-1883 |
NNS |
denotes |
Tas2rs |
T3064 |
1860-1863 |
DT |
denotes |
The |
T3063 |
1859-1932 |
sentence |
denotes |
The remaining 19 Tas2rs contained between one and 16 missense mutations. |
T3062 |
1858-1859 |
. |
denotes |
. |
T3061 |
1852-1858 |
NN |
denotes |
strain |
T3060 |
1847-1851 |
DT |
denotes |
this |
T3059 |
1844-1846 |
IN |
denotes |
in |
T3058 |
1832-1843 |
NNS |
denotes |
pseudogenes |
T3057 |
1825-1828 |
MD |
denotes |
may |
T3056 |
1815-1818 |
CD |
denotes |
two |
T3055 |
1819-1824 |
NNS |
denotes |
genes |
T3054 |
1809-1814 |
DT |
denotes |
these |
T3053 |
1807-1808 |
: |
denotes |
; |
T3052 |
1796-1807 |
NN |
denotes |
termination |
T3051 |
1786-1795 |
JJ |
denotes |
premature |
T3050 |
1782-1785 |
CC |
denotes |
and |
T3049 |
1775-1781 |
NNS |
denotes |
shifts |
T3048 |
1769-1774 |
NN |
denotes |
frame |
T3047 |
1762-1768 |
VBP |
denotes |
create |
T3046 |
1757-1761 |
WDT |
denotes |
that |
T3045 |
1747-1756 |
NNS |
denotes |
deletions |
T3042 |
1718-1726 |
NN |
denotes |
missense |
T3041 |
1727-1736 |
NNS |
denotes |
mutations |
T3040 |
1709-1717 |
JJ |
denotes |
numerous |
T3039 |
1829-1831 |
VB |
denotes |
be |
T3038 |
1697-1699 |
, |
denotes |
, |
T3037 |
1689-1697 |
NN |
denotes |
Tas2r117 |
T3036 |
1685-1688 |
CC |
denotes |
and |
T3035 |
1676-1684 |
NN |
denotes |
Tas2r103 |
T3034 |
1674-1676 |
, |
denotes |
, |
T3033 |
1699-1708 |
VBD |
denotes |
contained |
T3032 |
1664-1666 |
NN |
denotes |
D2 |
T3031 |
1667-1674 |
NNS |
denotes |
alleles |
T3030 |
1660-1663 |
CD |
denotes |
Two |
T3029 |
1659-1859 |
sentence |
denotes |
Two D2 alleles, Tas2r103 and Tas2r117, contained numerous missense mutations and small deletions that create frame shifts and premature termination; these two genes may be pseudogenes in this strain. |
T3028 |
1658-1659 |
. |
denotes |
. |
T3027 |
1654-1658 |
NNS |
denotes |
mice |
T3026 |
1651-1653 |
NN |
denotes |
D2 |
T3025 |
1648-1650 |
IN |
denotes |
in |
T3024 |
1637-1639 |
VBZ |
denotes |
is |
T3023 |
1631-1636 |
NN |
denotes |
Tas2r |
T3022 |
1626-1630 |
DT |
denotes |
this |
T3021 |
1640-1647 |
VBN |
denotes |
deleted |
T3020 |
1621-1625 |
IN |
denotes |
that |
T3019 |
1610-1620 |
VBG |
denotes |
suggesting |
T3018 |
1608-1610 |
, |
denotes |
, |
T3017 |
1607-1608 |
-RRB- |
denotes |
) |
T3016 |
1606-1607 |
CD |
denotes |
2 |
T3015 |
1590-1600 |
JJ |
denotes |
Additional |
T3014 |
1601-1605 |
NN |
denotes |
file |
T3013 |
1589-1590 |
-LRB- |
denotes |
( |
T3012 |
1572-1588 |
NNS |
denotes |
oligonucleotides |
T3011 |
1569-1571 |
IN |
denotes |
of |
T3010 |
1563-1568 |
NNS |
denotes |
pairs |
T3009 |
1559-1562 |
CD |
denotes |
two |
T3008 |
1556-1558 |
IN |
denotes |
of |
T3007 |
1549-1555 |
DT |
denotes |
either |
T3006 |
1543-1548 |
VBG |
denotes |
using |
T3005 |
1541-1542 |
-RRB- |
denotes |
) |
T3004 |
1540-1541 |
CD |
denotes |
5 |
T3003 |
1533-1539 |
NN |
denotes |
Figure |
T3002 |
1532-1533 |
-LRB- |
denotes |
( |
T3001 |
1520-1527 |
JJ |
denotes |
genomic |
T3000 |
1528-1531 |
NN |
denotes |
DNA |
T2999 |
1517-1519 |
NN |
denotes |
D2 |
T2998 |
1512-1516 |
IN |
denotes |
from |
T2997 |
1499-1501 |
VB |
denotes |
be |
T2996 |
1495-1498 |
RB |
denotes |
not |
T2995 |
1489-1494 |
MD |
denotes |
could |
T2994 |
1487-1489 |
, |
denotes |
, |
T2993 |
1479-1487 |
NN |
denotes |
Tas2r120 |
T2992 |
1477-1479 |
, |
denotes |
, |
T2991 |
1502-1511 |
VBN |
denotes |
amplified |
T2990 |
1472-1477 |
JJ |
denotes |
third |
T2989 |
1470-1471 |
DT |
denotes |
A |
T2988 |
1469-1659 |
sentence |
denotes |
A third, Tas2r120, could not be amplified from D2 genomic DNA (Figure 5) using either of two pairs of oligonucleotides (Additional file 2), suggesting that this Tas2r is deleted in D2 mice. |
T2987 |
1468-1469 |
. |
denotes |
. |
T2986 |
1467-1468 |
-RRB- |
denotes |
) |
T2985 |
1458-1461 |
RB |
denotes |
not |
T2984 |
1453-1457 |
NNS |
denotes |
data |
T2983 |
1462-1467 |
VBN |
denotes |
shown |
T2982 |
1452-1453 |
-LRB- |
denotes |
( |
T2981 |
1441-1445 |
NN |
denotes |
acid |
T2980 |
1435-1440 |
NN |
denotes |
amino |
T2979 |
1446-1451 |
NN |
denotes |
level |
T2978 |
1431-1434 |
DT |
denotes |
the |
T2977 |
1428-1430 |
IN |
denotes |
at |
T2976 |
1420-1427 |
NNS |
denotes |
strains |
T2975 |
1413-1419 |
IN |
denotes |
across |
T2974 |
1403-1412 |
JJ |
denotes |
identical |
T2973 |
1396-1398 |
, |
denotes |
, |
T2972 |
1388-1396 |
NN |
denotes |
Tas2r124 |
T2971 |
1384-1387 |
CC |
denotes |
and |
T2970 |
1375-1383 |
NN |
denotes |
Tas2r106 |
T2969 |
1373-1375 |
, |
denotes |
, |
T2968 |
1365-1373 |
VBN |
denotes |
examined |
T2967 |
1351-1356 |
NN |
denotes |
Tas2r |
T2966 |
1345-1346 |
HYPH |
denotes |
- |
T2965 |
1346-1350 |
CD |
denotes |
four |
T2964 |
1339-1345 |
CD |
denotes |
twenty |
T2963 |
1357-1364 |
NNS |
denotes |
alleles |
T2962 |
1335-1338 |
DT |
denotes |
the |
T2961 |
1332-1334 |
IN |
denotes |
of |
T2960 |
1328-1331 |
CD |
denotes |
two |
T2959 |
1323-1327 |
RB |
denotes |
only |
T2958 |
1398-1402 |
VBD |
denotes |
were |
T2957 |
1318-1322 |
IN |
denotes |
that |
T2956 |
1294-1296 |
NN |
denotes |
D2 |
T2955 |
1290-1293 |
CC |
denotes |
and |
T2954 |
1297-1308 |
NNS |
denotes |
orthologues |
T2953 |
1287-1289 |
NN |
denotes |
B6 |
T2952 |
1284-1286 |
IN |
denotes |
of |
T2951 |
1274-1283 |
NNS |
denotes |
sequences |
T2950 |
1270-1273 |
DT |
denotes |
the |
T2949 |
1267-1269 |
IN |
denotes |
of |
T2948 |
1309-1317 |
VBD |
denotes |
revealed |
T2947 |
1255-1266 |
NNS |
denotes |
Comparisons |
T2946 |
1254-1469 |
sentence |
denotes |
Comparisons of the sequences of B6 and D2 orthologues revealed that only two of the twenty-four Tas2r alleles examined, Tas2r106 and Tas2r124, were identical across strains at the amino acid level (data not shown). |
T2945 |
1253-1254 |
. |
denotes |
. |
T2944 |
1244-1253 |
VBN |
denotes |
sequenced |
T2943 |
1240-1243 |
CC |
denotes |
and |
T2942 |
1232-1239 |
NNS |
denotes |
vectors |
T2941 |
1224-1231 |
NN |
denotes |
cloning |
T2940 |
1219-1223 |
IN |
denotes |
into |
T2939 |
1204-1208 |
VBD |
denotes |
were |
T2938 |
1209-1218 |
VBN |
denotes |
subcloned |
T2937 |
1195-1203 |
NNS |
denotes |
products |
T2936 |
1191-1194 |
NN |
denotes |
PCR |
T2935 |
1190-1254 |
sentence |
denotes |
PCR products were subcloned into cloning vectors and sequenced. |
T2934 |
1189-1190 |
. |
denotes |
. |
T2933 |
1178-1185 |
JJ |
denotes |
genomic |
T2932 |
1186-1189 |
NN |
denotes |
DNA |
T2931 |
1175-1177 |
NN |
denotes |
D2 |
T2930 |
1170-1174 |
IN |
denotes |
from |
T2929 |
1154-1160 |
NN |
denotes |
coding |
T2928 |
1148-1153 |
NN |
denotes |
Tas2r |
T2927 |
1161-1169 |
NN |
denotes |
sequence |
T2926 |
1143-1147 |
DT |
denotes |
each |
T2925 |
1130-1132 |
PRP |
denotes |
we |
T2924 |
1128-1130 |
, |
denotes |
, |
T2923 |
1122-1128 |
NNS |
denotes |
oligos |
T2922 |
1116-1121 |
DT |
denotes |
these |
T2921 |
1133-1142 |
VBD |
denotes |
amplified |
T2920 |
1110-1115 |
VBG |
denotes |
Using |
T2919 |
1109-1190 |
sentence |
denotes |
Using these oligos, we amplified each Tas2r coding sequence from D2 genomic DNA. |
T2918 |
1108-1109 |
. |
denotes |
. |
T2917 |
1107-1108 |
-RRB- |
denotes |
] |
T2916 |
1106-1107 |
CD |
denotes |
2 |
T2915 |
1101-1105 |
NN |
denotes |
file |
T2914 |
1090-1100 |
JJ |
denotes |
Additional |
T2913 |
1086-1089 |
VB |
denotes |
see |
T2912 |
1085-1086 |
-LRB- |
denotes |
[ |
T2911 |
1072-1078 |
JJ |
denotes |
intact |
T2910 |
1079-1084 |
NN |
denotes |
Tas2r |
T2909 |
1067-1071 |
DT |
denotes |
each |
T2908 |
1064-1066 |
IN |
denotes |
of |
T2907 |
1048-1054 |
NN |
denotes |
coding |
T3279 |
3494-3504 |
JJ |
denotes |
diagnostic |
T3278 |
3517-3529 |
NN |
denotes |
endonuclease |
T3277 |
3491-3493 |
DT |
denotes |
no |
T3276 |
3539-3549 |
VBN |
denotes |
identified |
T3275 |
3485-3490 |
WRB |
denotes |
where |
T3274 |
3483-3484 |
-RRB- |
denotes |
) |
T3273 |
3475-3483 |
NN |
denotes |
Tas2r110 |
T3272 |
3471-3474 |
CC |
denotes |
and |
T3271 |
3462-3470 |
NN |
denotes |
Tas2r114 |
T3270 |
3460-3462 |
, |
denotes |
, |
T3269 |
3452-3460 |
NN |
denotes |
Tas2r104 |
T3268 |
3451-3452 |
-LRB- |
denotes |
( |
T3267 |
3445-3450 |
NNS |
denotes |
genes |
T3266 |
3439-3444 |
CD |
denotes |
three |
T3265 |
3427-3430 |
RB |
denotes |
not |
T3264 |
3423-3426 |
VBD |
denotes |
did |
T3263 |
3431-3438 |
VB |
denotes |
analyze |
T3262 |
3420-3422 |
PRP |
denotes |
We |
T3261 |
3419-3550 |
sentence |
denotes |
We did not analyze three genes (Tas2r104, Tas2r114 and Tas2r110) where no diagnostic restriction endonuclease could be identified. |
T2906 |
1055-1063 |
NN |
denotes |
sequence |
T2905 |
1044-1047 |
DT |
denotes |
the |
T2904 |
1035-1043 |
VBG |
denotes |
flanking |
T2903 |
1027-1034 |
NNS |
denotes |
regions |
T2902 |
1016-1026 |
JJ |
denotes |
non-coding |
T2901 |
1013-1015 |
IN |
denotes |
to |
T2900 |
996-1012 |
NNS |
denotes |
oligonucleotides |
T2899 |
987-995 |
VBD |
denotes |
designed |
T2898 |
984-986 |
PRP |
denotes |
We |
T2897 |
983-1109 |
sentence |
denotes |
We designed oligonucleotides to non-coding regions flanking the coding sequence of each intact Tas2r [see Additional file 2]. |
T2896 |
982-983 |
. |
denotes |
. |
T2895 |
981-982 |
-RRB- |
denotes |
) |
T2894 |
980-981 |
CD |
denotes |
4 |
T2893 |
973-979 |
NN |
denotes |
Figure |
T2892 |
972-973 |
-LRB- |
denotes |
( |
T2891 |
970-971 |
-RRB- |
denotes |
] |
T2890 |
968-970 |
CD |
denotes |
19 |
T2889 |
967-968 |
-LRB- |
denotes |
[ |
T2888 |
962-966 |
NNS |
denotes |
mice |
T2887 |
959-961 |
NN |
denotes |
B6 |
T2886 |
956-958 |
IN |
denotes |
of |
T2885 |
946-947 |
CD |
denotes |
6 |
T2884 |
935-945 |
NN |
denotes |
chromosome |
T2883 |
928-934 |
JJ |
denotes |
distal |
T2882 |
948-955 |
NN |
denotes |
cluster |
T2881 |
924-927 |
DT |
denotes |
the |
T2880 |
921-923 |
IN |
denotes |
in |
T2879 |
905-909 |
VBN |
denotes |
been |
T2878 |
900-904 |
VBP |
denotes |
have |
T2877 |
898-900 |
, |
denotes |
, |
T2876 |
881-886 |
NN |
denotes |
Tas2r |
T2875 |
872-880 |
JJ |
denotes |
apparent |
T2874 |
887-898 |
NNS |
denotes |
pseudogenes |
T2873 |
866-871 |
CD |
denotes |
three |
T2872 |
861-865 |
IN |
denotes |
with |
T2871 |
855-860 |
IN |
denotes |
along |
T2870 |
853-855 |
, |
denotes |
, |
T2869 |
910-920 |
VBN |
denotes |
identified |
T2868 |
840-846 |
JJ |
denotes |
intact |
T2867 |
847-853 |
NNS |
denotes |
Tas2rs |
T2866 |
834-835 |
HYPH |
denotes |
- |
T2865 |
835-839 |
CD |
denotes |
four |
T2864 |
828-834 |
CD |
denotes |
Twenty |
T2863 |
827-983 |
sentence |
denotes |
Twenty-four intact Tas2rs, along with three apparent Tas2r pseudogenes, have been identified in the distal chromosome 6 cluster of B6 mice [19] (Figure 4). |
T2862 |
826-827 |
. |
denotes |
. |
T2861 |
803-816 |
NN |
denotes |
insensitivity |
T2860 |
797-802 |
NN |
denotes |
taste |
T2859 |
792-796 |
NN |
denotes |
QHCl |
T2858 |
817-826 |
NN |
denotes |
phenotype |
T2857 |
788-791 |
DT |
denotes |
the |
T2856 |
783-787 |
IN |
denotes |
with |
T2855 |
767-772 |
MD |
denotes |
would |
T2854 |
758-760 |
NN |
denotes |
D2 |
T2853 |
751-757 |
JJ |
denotes |
single |
T2852 |
761-766 |
NN |
denotes |
Tas2r |
T2851 |
749-750 |
DT |
denotes |
a |
T2850 |
746-748 |
IN |
denotes |
of |
T2849 |
730-736 |
VBG |
denotes |
coding |
T2848 |
737-745 |
NN |
denotes |
sequence |
T2847 |
726-729 |
DT |
denotes |
the |
T2846 |
719-725 |
IN |
denotes |
within |
T2845 |
710-718 |
NN |
denotes |
mutation |
T2844 |
707-709 |
CC |
denotes |
or |
T2843 |
698-706 |
NN |
denotes |
deletion |
T2842 |
773-782 |
VB |
denotes |
correlate |
T2841 |
693-697 |
IN |
denotes |
that |
T2840 |
682-692 |
NN |
denotes |
likelihood |
T2839 |
678-681 |
DT |
denotes |
the |
T2838 |
675-677 |
IN |
denotes |
on |
T2837 |
657-666 |
RB |
denotes |
initially |
T2836 |
654-656 |
PRP |
denotes |
we |
T2835 |
652-654 |
, |
denotes |
, |
T2834 |
639-652 |
NNS |
denotes |
possibilities |
T2833 |
633-638 |
JJ |
denotes |
valid |
T2832 |
627-629 |
TO |
denotes |
to |
T2831 |
621-626 |
DT |
denotes |
these |
T2830 |
618-620 |
IN |
denotes |
of |
T2829 |
630-632 |
VB |
denotes |
be |
T2828 |
612-617 |
CD |
denotes |
three |
T2827 |
608-611 |
DT |
denotes |
all |
T2741 |
208-210 |
VBZ |
denotes |
is |
T2740 |
190-191 |
LS |
denotes |
1 |
T2739 |
189-190 |
-LRB- |
denotes |
( |
T2738 |
187-189 |
: |
denotes |
: |
T2737 |
165-171 |
JJ |
denotes |
likely |
T2736 |
172-187 |
NNS |
denotes |
characteristics |
T2735 |
159-164 |
CD |
denotes |
three |
T2734 |
156-158 |
IN |
denotes |
of |
T2733 |
152-155 |
CD |
denotes |
one |
T2732 |
138-143 |
MD |
denotes |
would |
T2731 |
126-131 |
NN |
denotes |
Tas2r |
T2730 |
124-125 |
-RRB- |
denotes |
) |
T2729 |
120-124 |
JJR |
denotes |
more |
T2728 |
117-119 |
CC |
denotes |
or |
T2727 |
116-117 |
-LRB- |
denotes |
( |
T2726 |
132-137 |
NNS |
denotes |
genes |
T2725 |
112-115 |
CD |
denotes |
one |
T2724 |
144-151 |
VB |
denotes |
exhibit |
T2723 |
107-111 |
IN |
denotes |
that |
T2722 |
544-551 |
VBZ |
denotes |
affects |
T2721 |
93-98 |
MD |
denotes |
would |
T2720 |
90-92 |
PRP |
denotes |
we |
T2719 |
88-90 |
, |
denotes |
, |
T2718 |
73-84 |
NN |
denotes |
sensitivity |
T2717 |
67-72 |
NN |
denotes |
taste |
T2716 |
62-66 |
NN |
denotes |
QHCl |
T2715 |
60-61 |
CD |
denotes |
6 |
T2714 |
49-59 |
NN |
denotes |
chromosome |
T2713 |
85-88 |
NN |
denotes |
QTL |
T2712 |
45-48 |
DT |
denotes |
the |
T2711 |
99-106 |
VB |
denotes |
predict |
T2710 |
27-28 |
-RRB- |
denotes |
) |
T2709 |
23-27 |
JJR |
denotes |
more |
T2708 |
20-22 |
CC |
denotes |
or |
T2707 |
19-20 |
-LRB- |
denotes |
( |
T2706 |
29-35 |
NNS |
denotes |
Tas2rs |
T2705 |
15-18 |
CD |
denotes |
one |
T2704 |
36-44 |
VBP |
denotes |
underlie |
T2703 |
12-14 |
IN |
denotes |
If |
T2702 |
11-586 |
sentence |
denotes |
If one (or more) Tas2rs underlie the chromosome 6 QHCl taste sensitivity QTL, we would predict that one (or more) Tas2r genes would exhibit one of three likely characteristics: (1) A Tas2r allele is a pseudogene, or is deleted, in D2 (QHCL-insensitive), but not B6 (QHCl-sensitive), mice; (2) Missense mutations in the single coding exon of a D2 Tas2r allele impact protein functions such as ligand binding or receptor coupling to downstream signaling cascades; (3) Mutations in noncoding or regulatory regions of a D2 Tas2r allele affects expression of the protein product. |
T2701 |
4-11 |
NNS |
denotes |
alleles |
T2700 |
0-3 |
NN |
denotes |
T2R |
T3044 |
1741-1746 |
JJ |
denotes |
small |
T3043 |
1737-1740 |
CC |
denotes |
and |
T2826 |
667-674 |
VBD |
denotes |
focused |
T2825 |
594-596 |
PRP |
denotes |
we |
T2824 |
597-607 |
VBD |
denotes |
considered |
T2823 |
587-593 |
IN |
denotes |
Though |
T2822 |
586-827 |
sentence |
denotes |
Though we considered all three of these to be valid possibilities, we initially focused on the likelihood that deletion or mutation within the coding sequence of a single D2 Tas2r would correlate with the QHCl taste insensitivity phenotype. |
T2821 |
585-586 |
. |
denotes |
. |
T2820 |
570-577 |
NN |
denotes |
protein |
T2819 |
578-585 |
NN |
denotes |
product |
T2818 |
566-569 |
DT |
denotes |
the |
T2817 |
563-565 |
IN |
denotes |
of |
T2816 |
552-562 |
NN |
denotes |
expression |
T2815 |
531-536 |
NN |
denotes |
Tas2r |
T2814 |
528-530 |
NN |
denotes |
D2 |
T2813 |
537-543 |
NN |
denotes |
allele |
T2812 |
526-527 |
DT |
denotes |
a |
T2811 |
523-525 |
IN |
denotes |
of |
T2810 |
504-514 |
JJ |
denotes |
regulatory |
T2809 |
501-503 |
CC |
denotes |
or |
T2808 |
515-522 |
NNS |
denotes |
regions |
T2807 |
491-500 |
JJ |
denotes |
noncoding |
T2806 |
488-490 |
IN |
denotes |
in |
T2805 |
478-487 |
NNS |
denotes |
Mutations |
T2804 |
476-477 |
-RRB- |
denotes |
) |
T2803 |
475-476 |
LS |
denotes |
3 |
T2802 |
474-475 |
-LRB- |
denotes |
( |
T2801 |
472-473 |
: |
denotes |
; |
T2800 |
454-463 |
NN |
denotes |
signaling |
T2799 |
464-472 |
NNS |
denotes |
cascades |
T2798 |
443-453 |
JJ |
denotes |
downstream |
T2797 |
440-442 |
IN |
denotes |
to |
T2796 |
431-439 |
NN |
denotes |
coupling |
T2795 |
422-430 |
NN |
denotes |
receptor |
T2794 |
419-421 |
CC |
denotes |
or |
T2793 |
411-418 |
NN |
denotes |
binding |
T2792 |
404-410 |
NN |
denotes |
ligand |
T2791 |
401-403 |
IN |
denotes |
as |
T2790 |
396-400 |
JJ |
denotes |
such |
T2789 |
386-395 |
NNS |
denotes |
functions |
T2788 |
378-385 |
NN |
denotes |
protein |
T2787 |
358-363 |
NN |
denotes |
Tas2r |
T2786 |
355-357 |
NN |
denotes |
D2 |
T2785 |
364-370 |
NN |
denotes |
allele |
T2784 |
353-354 |
DT |
denotes |
a |
T2783 |
350-352 |
IN |
denotes |
of |
T2782 |
338-344 |
VBG |
denotes |
coding |
T2781 |
331-337 |
JJ |
denotes |
single |
T2780 |
345-349 |
NN |
denotes |
exon |
T2779 |
327-330 |
DT |
denotes |
the |
T2778 |
324-326 |
IN |
denotes |
in |
T2777 |
314-323 |
NNS |
denotes |
mutations |
T2776 |
305-313 |
NN |
denotes |
Missense |
T2775 |
303-304 |
-RRB- |
denotes |
) |
T2774 |
371-377 |
VBP |
denotes |
impact |
T2773 |
302-303 |
LS |
denotes |
2 |
T2772 |
301-302 |
-LRB- |
denotes |
( |
T2771 |
299-300 |
: |
denotes |
; |
T2770 |
293-295 |
, |
denotes |
, |
T2769 |
292-293 |
-RRB- |
denotes |
) |
T2768 |
282-283 |
HYPH |
denotes |
- |
T2767 |
278-282 |
NN |
denotes |
QHCl |
T2766 |
283-292 |
JJ |
denotes |
sensitive |
T2765 |
277-278 |
-LRB- |
denotes |
( |
T2764 |
274-276 |
NN |
denotes |
B6 |
T2763 |
270-273 |
RB |
denotes |
not |
T2762 |
266-269 |
CC |
denotes |
but |
T2761 |
264-266 |
, |
denotes |
, |
T2760 |
263-264 |
-RRB- |
denotes |
) |
T2759 |
251-252 |
HYPH |
denotes |
- |
T2758 |
247-251 |
NN |
denotes |
QHCL |
T2757 |
252-263 |
JJ |
denotes |
insensitive |
T2756 |
246-247 |
-LRB- |
denotes |
( |
T2755 |
295-299 |
NNS |
denotes |
mice |
T2754 |
243-245 |
NN |
denotes |
D2 |
T2753 |
240-242 |
IN |
denotes |
in |
T2752 |
238-240 |
, |
denotes |
, |
T2751 |
231-238 |
VBN |
denotes |
deleted |
T2750 |
228-230 |
VBZ |
denotes |
is |
T2749 |
225-227 |
CC |
denotes |
or |
T2748 |
223-225 |
, |
denotes |
, |
T2747 |
213-223 |
NN |
denotes |
pseudogene |
T2746 |
211-212 |
DT |
denotes |
a |
T2745 |
195-200 |
NN |
denotes |
Tas2r |
T2744 |
201-207 |
NN |
denotes |
allele |
T2743 |
193-194 |
NN |
denotes |
A |
T2742 |
191-192 |
-RRB- |
denotes |
) |
T3154 |
2810-2821 |
NN |
denotes |
variability |
T3153 |
2810-3050 |
sentence |
denotes |
variability between orthologous receptors in these two inbred strains suggested that it might be possible to narrow the physical boundaries of the QHCl taste QTL by determining which Tas2r alleles are correlated with QHCl taste sensitivity. |
T3152 |
2807-2809 |
DT |
denotes |
he |
T3151 |
2807-2810 |
sentence |
denotes |
he |
T3150 |
2806-2807 |
NNS |
denotes |
T |
T3149 |
2806-2807 |
sentence |
denotes |
T |
T3148 |
2295-2296 |
sentence |
denotes |
|
T3147 |
2294-2295 |
. |
denotes |
. |
T3146 |
2293-2294 |
-RRB- |
denotes |
) |
T3145 |
2284-2287 |
RB |
denotes |
not |
R5231 |
T6978 |
T6979 |
amod |
Allelic,variation |
R5232 |
T6980 |
T6979 |
prep |
across,variation |
R5233 |
T6981 |
T6980 |
pobj |
strains,across |
R5234 |
T6982 |
T6979 |
prep |
for,variation |
R5235 |
T6983 |
T6984 |
nummod |
four,Tas2rs |
R5236 |
T6984 |
T6982 |
pobj |
Tas2rs,for |
R5237 |
T6985 |
T6979 |
punct |
.,variation |
R5238 |
T6987 |
T6988 |
nmod |
B6,alleles |
R5239 |
T6988 |
T6991 |
nsubjpass |
alleles,differentiated |
R5240 |
T6989 |
T6987 |
cc |
and,B6 |
R5241 |
T6990 |
T6987 |
conj |
D2,B6 |
R5242 |
T6992 |
T6988 |
prep |
of,alleles |
R5243 |
T6993 |
T6994 |
nummod |
four,Tas2rs |
R5244 |
T6994 |
T6992 |
pobj |
Tas2rs,of |
R5245 |
T6995 |
T6991 |
aux |
can,differentiated |
R5246 |
T6996 |
T6991 |
auxpass |
be,differentiated |
R5247 |
T6997 |
T6991 |
prep |
based,differentiated |
R5248 |
T6998 |
T6997 |
prep |
on,based |
R5249 |
T6999 |
T7000 |
amod |
diagnostic,digests |
R5250 |
T7000 |
T6998 |
pobj |
digests,on |
R5251 |
T7001 |
T7000 |
compound |
restriction,digests |
R5252 |
T7002 |
T7000 |
prep |
of,digests |
R5253 |
T7003 |
T7004 |
amod |
amplified,products |
R5254 |
T7004 |
T7002 |
pobj |
products,of |
R5255 |
T7005 |
T7004 |
compound |
PCR,products |
R5256 |
T7006 |
T7004 |
punct |
(,products |
R5257 |
T7007 |
T7004 |
appos |
Tas2r105,products |
R5258 |
T7008 |
T7007 |
punct |
", ",Tas2r105 |
R5259 |
T7009 |
T7007 |
conj |
Tas2r116,Tas2r105 |
R5260 |
T7010 |
T7009 |
cc |
and,Tas2r116 |
R5261 |
T7011 |
T7009 |
conj |
Tas2r131,Tas2r116 |
R5262 |
T7012 |
T6998 |
punct |
),on |
R5263 |
T7013 |
T6998 |
cc |
or,on |
R5264 |
T7014 |
T6998 |
conj |
on,on |
R5265 |
T7015 |
T7016 |
det |
the,presence |
R5266 |
T7016 |
T7014 |
pobj |
presence,on |
R5267 |
T7017 |
T7016 |
cc |
or,presence |
R5268 |
T7018 |
T7016 |
conj |
absence,presence |
R5269 |
T7019 |
T7016 |
prep |
of,presence |
R5270 |
T7020 |
T7021 |
det |
a,product |
R5271 |
T7021 |
T7019 |
pobj |
product,of |
R5272 |
T7022 |
T7021 |
compound |
PCR,product |
R5273 |
T7023 |
T7021 |
punct |
(,product |
R5274 |
T7024 |
T7021 |
appos |
Tas2r120,product |
R5275 |
T7025 |
T6991 |
punct |
),differentiated |
R5276 |
T7026 |
T6991 |
punct |
.,differentiated |
R5277 |
T7028 |
T7029 |
prep |
In,correlated |
R5278 |
T7030 |
T7028 |
pobj |
each,In |
R5279 |
T7031 |
T7030 |
prep |
of,each |
R5280 |
T7032 |
T7033 |
det |
the,strains |
R5281 |
T7033 |
T7031 |
pobj |
strains,of |
R5282 |
T7034 |
T7033 |
nummod |
17,strains |
R5283 |
T7035 |
T7033 |
compound |
BXD,strains |
R5284 |
T7036 |
T7033 |
acl |
tested,strains |
R5285 |
T7037 |
T7029 |
punct |
", ",correlated |
R5286 |
T7038 |
T7039 |
compound |
Tas2r,genotype |
R5287 |
T7039 |
T7029 |
nsubjpass |
genotype,correlated |
R5288 |
T7040 |
T7029 |
auxpass |
was,correlated |
R5289 |
T7041 |
T7029 |
advmod |
always,correlated |
R5290 |
T7042 |
T7029 |
prep |
with,correlated |
R5291 |
T7043 |
T7044 |
compound |
QHCl,taster |
R5292 |
T7044 |
T7045 |
compound |
taster,phenotype |
R5293 |
T7045 |
T7042 |
pobj |
phenotype,with |
R5294 |
T7046 |
T7047 |
punct |
(,phenotype |
R5295 |
T7047 |
T7045 |
parataxis |
phenotype,phenotype |
R5296 |
T7048 |
T7049 |
nsubj |
blue,phenotype |
R5297 |
T7049 |
T7047 |
ccomp |
phenotype,phenotype |
R5298 |
T7050 |
T7049 |
punct |
=,phenotype |
R5299 |
T7051 |
T7052 |
compound |
B6,taster |
R5300 |
T7052 |
T7049 |
compound |
taster,phenotype |
R5301 |
T7053 |
T7047 |
punct |
", ",phenotype |
R5302 |
T7054 |
T7047 |
nsubj |
red,phenotype |
R5303 |
T7055 |
T7047 |
punct |
=,phenotype |
R5304 |
T7056 |
T7057 |
compound |
D2,taster |
R5305 |
T7057 |
T7047 |
compound |
taster,phenotype |
R5306 |
T7058 |
T7047 |
punct |
),phenotype |
R5307 |
T7059 |
T7029 |
punct |
.,correlated |
R5308 |
T7062 |
T7063 |
amod |
additional,file |
R5309 |
T7063 |
T7061 |
dobj |
file,See |
R5310 |
T7064 |
T7063 |
nummod |
1,file |
R5311 |
T7065 |
T7063 |
punct |
: ,file |
R5312 |
T7066 |
T7063 |
npadvmod |
Table,file |
R5313 |
T7067 |
T7066 |
nummod |
3,Table |
R5314 |
T7068 |
T7061 |
prep |
for,See |
R5315 |
T7069 |
T7070 |
compound |
restriction,enzymes |
R5316 |
T7070 |
T7068 |
pobj |
enzymes,for |
R5317 |
T7071 |
T7070 |
cc |
and,enzymes |
R5318 |
T7072 |
T7070 |
conj |
oligonucleotides,enzymes |
R5319 |
T7073 |
T7061 |
punct |
.,See |
R5320 |
T7095 |
T7096 |
det |
The,cluster |
R5321 |
T7096 |
T7098 |
nsubj |
cluster,is |
R5322 |
T7097 |
T7096 |
compound |
Tas2r,cluster |
R5323 |
T7099 |
T7100 |
det |
a,haplotype |
R5324 |
T7100 |
T7098 |
attr |
haplotype,is |
R5325 |
T7101 |
T7100 |
amod |
single,haplotype |
R5326 |
T7102 |
T7098 |
prep |
in,is |
R5327 |
T7103 |
T7104 |
nmod |
BXD,Ty |
R5328 |
T7104 |
T7106 |
nmod |
Ty,mice |
R5329 |
T7105 |
T7104 |
punct |
/,Ty |
R5330 |
T7106 |
T7102 |
pobj |
mice,in |
R5331 |
T7107 |
T7106 |
amod |
RI,mice |
R5332 |
T7108 |
T7098 |
punct |
.,is |
R5333 |
T7110 |
T7111 |
det |
The,exon |
R5334 |
T7111 |
T7113 |
nsubj |
exon,was |
R5335 |
T7112 |
T7111 |
amod |
coding,exon |
R5336 |
T7114 |
T7111 |
prep |
of,exon |
R5337 |
T7115 |
T7114 |
pobj |
each,of |
R5338 |
T7116 |
T7115 |
prep |
of,each |
R5339 |
T7117 |
T7118 |
nummod |
21,Tas2rs |
R5340 |
T7118 |
T7116 |
pobj |
Tas2rs,of |
R5341 |
T7119 |
T7118 |
prep |
in,Tas2rs |
R5342 |
T7120 |
T7121 |
det |
the,cluster |
R5343 |
T7121 |
T7119 |
pobj |
cluster,in |
R5344 |
T7122 |
T7121 |
amod |
distal,cluster |
R5345 |
T7123 |
T7121 |
nmod |
chromosome,cluster |
R5346 |
T7124 |
T7123 |
nummod |
6,chromosome |
R5347 |
T7125 |
T7126 |
amod |
amplified,DNA |
R5348 |
T7126 |
T7113 |
attr |
DNA,was |
R5349 |
T7127 |
T7126 |
amod |
genomic,DNA |
R5350 |
T7128 |
T7126 |
prep |
from,DNA |
R5351 |
T7129 |
T7130 |
nummod |
29,strains |
R5352 |
T7130 |
T7128 |
pobj |
strains,from |
R5353 |
T7131 |
T7132 |
nmod |
BXD,Ty |
R5354 |
T7132 |
T7130 |
nmod |
Ty,strains |
R5355 |
T7133 |
T7132 |
punct |
/,Ty |
R5356 |
T7134 |
T7130 |
amod |
RI,strains |
R5357 |
T7135 |
T7113 |
punct |
.,was |
R5358 |
T7137 |
T7138 |
det |
Each,Tas2r |
R5359 |
T7138 |
T7139 |
nsubj |
Tas2r,originated |
R5360 |
T7140 |
T7138 |
prep |
within,Tas2r |
R5361 |
T7141 |
T7142 |
det |
an,strain |
R5362 |
T7142 |
T7140 |
pobj |
strain,within |
R5363 |
T7143 |
T7142 |
amod |
individual,strain |
R5364 |
T7144 |
T7142 |
compound |
BXD,strain |
R5365 |
T7145 |
T7139 |
prep |
from,originated |
R5366 |
T7146 |
T7147 |
det |
the,strain |
R5367 |
T7147 |
T7145 |
pobj |
strain,from |
R5368 |
T7148 |
T7147 |
amod |
same,strain |
R5369 |
T7149 |
T7147 |
amod |
parental,strain |
R5370 |
T7150 |
T7151 |
punct |
(,white |
R5371 |
T7151 |
T7139 |
parataxis |
white,originated |
R5372 |
T7152 |
T7153 |
compound |
B6,allele |
R5373 |
T7153 |
T7154 |
nsubj |
allele,gray |
R5374 |
T7154 |
T7151 |
ccomp |
gray,white |
R5375 |
T7155 |
T7154 |
punct |
=,gray |
R5376 |
T7156 |
T7151 |
punct |
", ",white |
R5377 |
T7157 |
T7158 |
compound |
D2,allele |
R5378 |
T7158 |
T7151 |
nsubj |
allele,white |
R5379 |
T7159 |
T7151 |
punct |
=,white |
R5380 |
T7160 |
T7151 |
punct |
),white |
R5381 |
T7161 |
T7139 |
punct |
.,originated |
R5382 |
T7163 |
T7164 |
det |
The,strains |
R5383 |
T7164 |
T7167 |
nsubjpass |
strains,indicated |
R5384 |
T7165 |
T7164 |
nummod |
17,strains |
R5385 |
T7166 |
T7164 |
compound |
BXD,strains |
R5386 |
T7168 |
T7169 |
dep |
that,tested |
R5387 |
T7169 |
T7164 |
relcl |
tested,strains |
R5388 |
T7170 |
T7169 |
auxpass |
were,tested |
R5389 |
T7171 |
T7169 |
advmod |
behaviorally,tested |
R5390 |
T7172 |
T7169 |
prep |
in,tested |
R5391 |
T7173 |
T7174 |
det |
this,study |
R5392 |
T7174 |
T7172 |
pobj |
study,in |
R5393 |
T7175 |
T7167 |
auxpass |
are,indicated |
R5394 |
T7176 |
T7177 |
punct |
(,* |
R5395 |
T7177 |
T7167 |
punct |
*,indicated |
R5396 |
T7178 |
T7177 |
punct |
),* |
R5397 |
T7179 |
T7167 |
punct |
.,indicated |
R5398 |
T7207 |
T7208 |
compound |
Tas2r,genotype |
R5399 |
T7208 |
T7209 |
nsubj |
genotype,correlates |
R5400 |
T7210 |
T7209 |
prep |
with,correlates |
R5401 |
T7211 |
T7212 |
compound |
QHCl,taste |
R5402 |
T7212 |
T7213 |
compound |
taste,phenotype |
R5403 |
T7213 |
T7210 |
pobj |
phenotype,with |
R5404 |
T7214 |
T7209 |
punct |
.,correlates |
R5405 |
T7216 |
T7217 |
compound |
Mean,ratios |
R5406 |
T7217 |
T7219 |
nsubjpass |
ratios,grouped |
R5407 |
T7218 |
T7217 |
compound |
lick,ratios |
R5408 |
T7220 |
T7217 |
prep |
of,ratios |
R5409 |
T7221 |
T7222 |
nmod |
B6,strains |
R5410 |
T7222 |
T7220 |
pobj |
strains,of |
R5411 |
T7223 |
T7221 |
punct |
", ",B6 |
R5412 |
T7224 |
T7221 |
conj |
D2,B6 |
R5413 |
T7225 |
T7224 |
cc |
and,D2 |
R5414 |
T7226 |
T7224 |
conj |
BXD,D2 |
R5415 |
T7227 |
T7222 |
acl |
reported,strains |
R5416 |
T7228 |
T7227 |
prep |
in,reported |
R5417 |
T7229 |
T7228 |
pobj |
Figure,in |
R5418 |
T7230 |
T7229 |
nummod |
1,Figure |
R5419 |
T7231 |
T7219 |
auxpass |
are,grouped |
R5420 |
T7232 |
T7219 |
prep |
based,grouped |
R5421 |
T7233 |
T7232 |
prep |
on,based |
R5422 |
T7234 |
T7235 |
compound |
Tas2r,haplotype |
R5423 |
T7235 |
T7233 |
pobj |
haplotype,on |
R5424 |
T7236 |
T7237 |
punct |
(,red |
R5425 |
T7237 |
T7219 |
parataxis |
red,grouped |
R5426 |
T7238 |
T7239 |
compound |
B6,haplotype |
R5427 |
T7239 |
T7240 |
nsubj |
haplotype,blue |
R5428 |
T7240 |
T7237 |
ccomp |
blue,red |
R5429 |
T7241 |
T7240 |
punct |
=,blue |
R5430 |
T7242 |
T7237 |
punct |
", ",red |
R5431 |
T7243 |
T7244 |
compound |
D2,haplotype |
R5432 |
T7244 |
T7237 |
nsubj |
haplotype,red |
R5433 |
T7245 |
T7237 |
punct |
=,red |
R5434 |
T7246 |
T7237 |
punct |
),red |
R5435 |
T7247 |
T7219 |
punct |
.,grouped |
R5436 |
T7249 |
T7250 |
compound |
B6,mice |
R5437 |
T7250 |
T7251 |
nsubj |
mice,are |
R5438 |
T7252 |
T7253 |
punct |
(,line |
R5439 |
T7253 |
T7250 |
parataxis |
line,mice |
R5440 |
T7254 |
T7253 |
amod |
blue,line |
R5441 |
T7255 |
T7253 |
prep |
on,line |
R5442 |
T7256 |
T7257 |
amod |
left,panel |
R5443 |
T7257 |
T7255 |
pobj |
panel,on |
R5444 |
T7258 |
T7253 |
punct |
),line |
R5445 |
T7259 |
T7260 |
advmod |
more,sensitive |
R5446 |
T7260 |
T7251 |
acomp |
sensitive,are |
R5447 |
T7261 |
T7260 |
prep |
to,sensitive |
R5448 |
T7262 |
T7263 |
nummod |
1,mM |
R5449 |
T7263 |
T7264 |
nmod |
mM,QHCl |
R5450 |
T7264 |
T7261 |
pobj |
QHCl,to |
R5451 |
T7265 |
T7263 |
cc |
and,mM |
R5452 |
T7266 |
T7267 |
nummod |
3,mM |
R5453 |
T7267 |
T7263 |
conj |
mM,mM |
R5454 |
T7268 |
T7269 |
mark |
than,are |
R5455 |
T7269 |
T7260 |
advcl |
are,sensitive |
R5456 |
T7270 |
T7271 |
compound |
D2,mice |
R5457 |
T7271 |
T7269 |
nsubj |
mice,are |
R5458 |
T7272 |
T7273 |
punct |
(,line |
R5459 |
T7273 |
T7271 |
parataxis |
line,mice |
R5460 |
T7274 |
T7273 |
amod |
red,line |
R5461 |
T7275 |
T7273 |
prep |
on,line |
R5462 |
T7276 |
T7277 |
amod |
left,panel |
R5463 |
T7277 |
T7275 |
pobj |
panel,on |
R5464 |
T7278 |
T7273 |
punct |
),line |
R5465 |
T7279 |
T7269 |
prep |
in,are |
R5466 |
T7280 |
T7281 |
amod |
brief,access |
R5467 |
T7281 |
T7282 |
compound |
access,tests |
R5468 |
T7282 |
T7279 |
pobj |
tests,in |
R5469 |
T7283 |
T7282 |
compound |
taste,tests |
R5470 |
T7284 |
T7251 |
punct |
.,are |
R5471 |
T7286 |
T7287 |
advmod |
Similarly,are |
R5472 |
T7288 |
T7287 |
punct |
", ",are |
R5473 |
T7289 |
T7290 |
compound |
BXD,strains |
R5474 |
T7290 |
T7287 |
nsubj |
strains,are |
R5475 |
T7291 |
T7290 |
prep |
with,strains |
R5476 |
T7292 |
T7293 |
det |
the,haplotype |
R5477 |
T7293 |
T7291 |
pobj |
haplotype,with |
R5478 |
T7294 |
T7295 |
compound |
B6,Tas2r |
R5479 |
T7295 |
T7293 |
compound |
Tas2r,haplotype |
R5480 |
T7296 |
T7297 |
punct |
(,panel |
R5481 |
T7297 |
T7293 |
parataxis |
panel,haplotype |
R5482 |
T7298 |
T7299 |
amod |
blue,lines |
R5483 |
T7299 |
T7297 |
dep |
lines,panel |
R5484 |
T7300 |
T7297 |
punct |
", ",panel |
R5485 |
T7301 |
T7297 |
amod |
right,panel |
R5486 |
T7302 |
T7297 |
punct |
),panel |
R5487 |
T7303 |
T7304 |
advmod |
more,sensitive |
R5488 |
T7304 |
T7287 |
acomp |
sensitive,are |
R5489 |
T7305 |
T7304 |
prep |
to,sensitive |
R5490 |
T7306 |
T7305 |
pobj |
QHCl,to |
R5491 |
T7307 |
T7308 |
mark |
than,are |
R5492 |
T7308 |
T7304 |
advcl |
are,sensitive |
R5493 |
T7309 |
T7310 |
compound |
BXD,strains |
R5494 |
T7310 |
T7308 |
nsubj |
strains,are |
R5495 |
T7311 |
T7310 |
prep |
with,strains |
R5496 |
T7312 |
T7313 |
det |
the,haplotype |
R5497 |
T7313 |
T7311 |
pobj |
haplotype,with |
R5498 |
T7314 |
T7315 |
compound |
D2,Tas2r |
R5499 |
T7315 |
T7313 |
compound |
Tas2r,haplotype |
R5500 |
T7316 |
T7317 |
punct |
(,panel |
R5501 |
T7317 |
T7308 |
parataxis |
panel,are |
R5502 |
T7318 |
T7319 |
amod |
red,lines |
R5503 |
T7319 |
T7317 |
dep |
lines,panel |
R5504 |
T7320 |
T7317 |
punct |
", ",panel |
R5505 |
T7321 |
T7317 |
amod |
right,panel |
R5506 |
T7322 |
T7317 |
punct |
),panel |
R5507 |
T7323 |
T7287 |
punct |
.,are |
R5508 |
T7325 |
T7326 |
det |
The,strains |
R5509 |
T7326 |
T7328 |
nsubjpass |
strains,listed |
R5510 |
T7327 |
T7326 |
compound |
BXD,strains |
R5511 |
T7329 |
T7328 |
auxpass |
are,listed |
R5512 |
T7330 |
T7328 |
prep |
in,listed |
R5513 |
T7331 |
T7330 |
pobj |
order,in |
R5514 |
T7332 |
T7328 |
prep |
from,listed |
R5515 |
T7333 |
T7332 |
amod |
least,from |
R5516 |
T7334 |
T7332 |
prep |
to,from |
R5517 |
T7335 |
T7334 |
amod |
most,to |
R5518 |
T7336 |
T7332 |
amod |
sensitive,from |
R5519 |
T7337 |
T7336 |
prep |
to,sensitive |
R5520 |
T7338 |
T7339 |
nummod |
1,mM |
R5521 |
T7339 |
T7340 |
compound |
mM,QHCL |
R5522 |
T7340 |
T7337 |
pobj |
QHCL,to |
R5523 |
T7341 |
T7328 |
punct |
.,listed |
R1865 |
T2700 |
T2701 |
compound |
T2R,alleles |
R1866 |
T2703 |
T2704 |
mark |
If,underlie |
R1867 |
T2704 |
T2711 |
advcl |
underlie,predict |
R1868 |
T2705 |
T2706 |
nummod |
one,Tas2rs |
R1869 |
T2706 |
T2704 |
nsubj |
Tas2rs,underlie |
R1870 |
T2707 |
T2705 |
punct |
(,one |
R1871 |
T2708 |
T2705 |
cc |
or,one |
R1872 |
T2709 |
T2705 |
conj |
more,one |
R1873 |
T2710 |
T2706 |
punct |
),Tas2rs |
R1874 |
T2711 |
T2722 |
ccomp |
predict,affects |
R1875 |
T2712 |
T2713 |
det |
the,QTL |
R1876 |
T2713 |
T2704 |
dobj |
QTL,underlie |
R1877 |
T2714 |
T2713 |
nmod |
chromosome,QTL |
R1878 |
T2715 |
T2714 |
nummod |
6,chromosome |
R1879 |
T2716 |
T2713 |
compound |
QHCl,QTL |
R1880 |
T2717 |
T2718 |
compound |
taste,sensitivity |
R1881 |
T2718 |
T2713 |
compound |
sensitivity,QTL |
R1882 |
T2719 |
T2711 |
punct |
", ",predict |
R1883 |
T2720 |
T2711 |
nsubj |
we,predict |
R1884 |
T2721 |
T2711 |
aux |
would,predict |
R1885 |
T2723 |
T2724 |
mark |
that,exhibit |
R1886 |
T2724 |
T2711 |
ccomp |
exhibit,predict |
R1887 |
T2725 |
T2726 |
nummod |
one,genes |
R1888 |
T2726 |
T2724 |
nsubj |
genes,exhibit |
R1889 |
T2727 |
T2725 |
punct |
(,one |
R1890 |
T2728 |
T2725 |
cc |
or,one |
R1891 |
T2729 |
T2725 |
conj |
more,one |
R1892 |
T2730 |
T2726 |
punct |
),genes |
R1893 |
T2731 |
T2726 |
compound |
Tas2r,genes |
R1894 |
T2732 |
T2724 |
aux |
would,exhibit |
R1895 |
T2733 |
T2724 |
dobj |
one,exhibit |
R1896 |
T2734 |
T2733 |
prep |
of,one |
R1897 |
T2735 |
T2736 |
nummod |
three,characteristics |
R1898 |
T2736 |
T2734 |
pobj |
characteristics,of |
R1899 |
T2737 |
T2736 |
amod |
likely,characteristics |
R1900 |
T2738 |
T2722 |
punct |
: ,affects |
R1901 |
T2739 |
T2740 |
punct |
(,1 |
R1902 |
T2740 |
T2741 |
meta |
1,is |
R1903 |
T2741 |
T2722 |
ccomp |
is,affects |
R1904 |
T2742 |
T2740 |
punct |
),1 |
R1905 |
T2743 |
T2744 |
compound |
A,allele |
R1906 |
T2744 |
T2741 |
nsubj |
allele,is |
R1907 |
T2745 |
T2744 |
compound |
Tas2r,allele |
R1908 |
T2746 |
T2747 |
det |
a,pseudogene |
R1909 |
T2747 |
T2741 |
attr |
pseudogene,is |
R1910 |
T2748 |
T2741 |
punct |
", ",is |
R1911 |
T2749 |
T2741 |
cc |
or,is |
R1912 |
T2750 |
T2751 |
auxpass |
is,deleted |
R1913 |
T2751 |
T2741 |
conj |
deleted,is |
R1914 |
T2752 |
T2751 |
punct |
", ",deleted |
R1915 |
T2753 |
T2751 |
prep |
in,deleted |
R1916 |
T2754 |
T2755 |
nmod |
D2,mice |
R1917 |
T2755 |
T2753 |
pobj |
mice,in |
R1918 |
T2756 |
T2757 |
punct |
(,insensitive |
R1919 |
T2757 |
T2754 |
parataxis |
insensitive,D2 |
R1920 |
T2758 |
T2757 |
npadvmod |
QHCL,insensitive |
R1921 |
T2759 |
T2757 |
punct |
-,insensitive |
R1922 |
T2760 |
T2757 |
punct |
),insensitive |
R1923 |
T2761 |
T2754 |
punct |
", ",D2 |
R1924 |
T2762 |
T2754 |
cc |
but,D2 |
R1925 |
T2763 |
T2762 |
neg |
not,but |
R1926 |
T2764 |
T2754 |
conj |
B6,D2 |
R1927 |
T2765 |
T2766 |
punct |
(,sensitive |
R1928 |
T2766 |
T2764 |
parataxis |
sensitive,B6 |
R1929 |
T2767 |
T2766 |
npadvmod |
QHCl,sensitive |
R1930 |
T2768 |
T2766 |
punct |
-,sensitive |
R1931 |
T2769 |
T2766 |
punct |
),sensitive |
R1932 |
T2770 |
T2755 |
punct |
", ",mice |
R1933 |
T2771 |
T2722 |
punct |
;,affects |
R1934 |
T2772 |
T2773 |
punct |
(,2 |
R1935 |
T2773 |
T2774 |
meta |
2,impact |
R1936 |
T2774 |
T2722 |
ccomp |
impact,affects |
R1937 |
T2775 |
T2773 |
punct |
),2 |
R1938 |
T2776 |
T2777 |
compound |
Missense,mutations |
R1939 |
T2777 |
T2774 |
nsubj |
mutations,impact |
R1940 |
T2778 |
T2777 |
prep |
in,mutations |
R1941 |
T2779 |
T2780 |
det |
the,exon |
R1942 |
T2780 |
T2778 |
pobj |
exon,in |
R1943 |
T2781 |
T2780 |
amod |
single,exon |
R1944 |
T2782 |
T2780 |
amod |
coding,exon |
R1945 |
T2783 |
T2780 |
prep |
of,exon |
R1946 |
T2784 |
T2785 |
det |
a,allele |
R1947 |
T2785 |
T2783 |
pobj |
allele,of |
R1948 |
T2786 |
T2785 |
compound |
D2,allele |
R1949 |
T2787 |
T2785 |
compound |
Tas2r,allele |
R1950 |
T2788 |
T2789 |
compound |
protein,functions |
R1951 |
T2789 |
T2774 |
dobj |
functions,impact |
R1952 |
T2790 |
T2791 |
amod |
such,as |
R1953 |
T2791 |
T2789 |
prep |
as,functions |
R1954 |
T2792 |
T2793 |
compound |
ligand,binding |
R1955 |
T2793 |
T2791 |
pobj |
binding,as |
R1956 |
T2794 |
T2793 |
cc |
or,binding |
R1957 |
T2795 |
T2796 |
compound |
receptor,coupling |
R1958 |
T2796 |
T2793 |
conj |
coupling,binding |
R1959 |
T2797 |
T2796 |
prep |
to,coupling |
R1960 |
T2798 |
T2799 |
amod |
downstream,cascades |
R1961 |
T2799 |
T2797 |
pobj |
cascades,to |
R1962 |
T2800 |
T2799 |
compound |
signaling,cascades |
R1963 |
T2801 |
T2722 |
punct |
;,affects |
R1964 |
T2802 |
T2803 |
punct |
(,3 |
R1965 |
T2803 |
T2722 |
meta |
3,affects |
R1966 |
T2804 |
T2803 |
punct |
),3 |
R1967 |
T2805 |
T2722 |
nsubj |
Mutations,affects |
R1968 |
T2806 |
T2805 |
prep |
in,Mutations |
R1969 |
T2807 |
T2808 |
amod |
noncoding,regions |
R1970 |
T2808 |
T2806 |
pobj |
regions,in |
R1971 |
T2809 |
T2807 |
cc |
or,noncoding |
R1972 |
T2810 |
T2807 |
conj |
regulatory,noncoding |
R1973 |
T2811 |
T2808 |
prep |
of,regions |
R1974 |
T2812 |
T2813 |
det |
a,allele |
R1975 |
T2813 |
T2811 |
pobj |
allele,of |
R1976 |
T2814 |
T2813 |
compound |
D2,allele |
R1977 |
T2815 |
T2813 |
compound |
Tas2r,allele |
R1978 |
T2816 |
T2722 |
dobj |
expression,affects |
R1979 |
T2817 |
T2816 |
prep |
of,expression |
R1980 |
T2818 |
T2819 |
det |
the,product |
R1981 |
T2819 |
T2817 |
pobj |
product,of |
R1982 |
T2820 |
T2819 |
compound |
protein,product |
R1983 |
T2821 |
T2722 |
punct |
.,affects |
R1984 |
T2823 |
T2824 |
mark |
Though,considered |
R1985 |
T2824 |
T2826 |
advcl |
considered,focused |
R1986 |
T2825 |
T2824 |
nsubj |
we,considered |
R1987 |
T2827 |
T2828 |
det |
all,three |
R1988 |
T2828 |
T2829 |
nsubj |
three,be |
R1989 |
T2829 |
T2824 |
ccomp |
be,considered |
R1990 |
T2830 |
T2828 |
prep |
of,three |
R1991 |
T2831 |
T2830 |
pobj |
these,of |
R1992 |
T2832 |
T2829 |
aux |
to,be |
R1993 |
T2833 |
T2834 |
amod |
valid,possibilities |
R1994 |
T2834 |
T2829 |
attr |
possibilities,be |
R1995 |
T2835 |
T2826 |
punct |
", ",focused |
R1996 |
T2836 |
T2826 |
nsubj |
we,focused |
R1997 |
T2837 |
T2826 |
advmod |
initially,focused |
R1998 |
T2838 |
T2826 |
prep |
on,focused |
R1999 |
T2839 |
T2840 |
det |
the,likelihood |
R2000 |
T2840 |
T2838 |
pobj |
likelihood,on |
R2001 |
T2841 |
T2842 |
mark |
that,correlate |
R2002 |
T2842 |
T2840 |
acl |
correlate,likelihood |
R2003 |
T2843 |
T2842 |
nsubj |
deletion,correlate |
R2004 |
T2844 |
T2843 |
cc |
or,deletion |
R2005 |
T2845 |
T2843 |
conj |
mutation,deletion |
R2006 |
T2846 |
T2843 |
prep |
within,deletion |
R2007 |
T2847 |
T2848 |
det |
the,sequence |
R2008 |
T2848 |
T2846 |
pobj |
sequence,within |
R2009 |
T2849 |
T2848 |
amod |
coding,sequence |
R2010 |
T2850 |
T2848 |
prep |
of,sequence |
R2011 |
T2851 |
T2852 |
det |
a,Tas2r |
R2012 |
T2852 |
T2850 |
pobj |
Tas2r,of |
R2013 |
T2853 |
T2852 |
amod |
single,Tas2r |
R2014 |
T2854 |
T2852 |
compound |
D2,Tas2r |
R2015 |
T2855 |
T2842 |
aux |
would,correlate |
R2016 |
T2856 |
T2842 |
prep |
with,correlate |
R2017 |
T2857 |
T2858 |
det |
the,phenotype |
R2018 |
T2858 |
T2856 |
pobj |
phenotype,with |
R2019 |
T2859 |
T2860 |
compound |
QHCl,taste |
R2020 |
T2860 |
T2861 |
compound |
taste,insensitivity |
R2021 |
T2861 |
T2858 |
compound |
insensitivity,phenotype |
R2022 |
T2862 |
T2826 |
punct |
.,focused |
R2023 |
T2864 |
T2865 |
compound |
Twenty,four |
R2024 |
T2865 |
T2867 |
nummod |
four,Tas2rs |
R2025 |
T2866 |
T2865 |
punct |
-,four |
R2026 |
T2867 |
T2869 |
nsubjpass |
Tas2rs,identified |
R2027 |
T2868 |
T2867 |
amod |
intact,Tas2rs |
R2028 |
T2870 |
T2867 |
punct |
", ",Tas2rs |
R2029 |
T2871 |
T2867 |
prep |
along,Tas2rs |
R2030 |
T2872 |
T2871 |
prep |
with,along |
R2031 |
T2873 |
T2874 |
nummod |
three,pseudogenes |
R2032 |
T2874 |
T2872 |
pobj |
pseudogenes,with |
R2033 |
T2875 |
T2874 |
amod |
apparent,pseudogenes |
R2034 |
T2876 |
T2874 |
compound |
Tas2r,pseudogenes |
R2035 |
T2877 |
T2869 |
punct |
", ",identified |
R2036 |
T2878 |
T2869 |
aux |
have,identified |
R2037 |
T2879 |
T2869 |
auxpass |
been,identified |
R2038 |
T2880 |
T2869 |
prep |
in,identified |
R2039 |
T2881 |
T2882 |
det |
the,cluster |
R2040 |
T2882 |
T2880 |
pobj |
cluster,in |
R2041 |
T2883 |
T2882 |
amod |
distal,cluster |
R2042 |
T2884 |
T2882 |
nmod |
chromosome,cluster |
R2043 |
T2885 |
T2884 |
nummod |
6,chromosome |
R2044 |
T2886 |
T2882 |
prep |
of,cluster |
R2045 |
T2887 |
T2888 |
compound |
B6,mice |
R2046 |
T2888 |
T2886 |
pobj |
mice,of |
R2047 |
T2889 |
T2890 |
punct |
[,19 |
R2048 |
T2890 |
T2869 |
parataxis |
19,identified |
R2049 |
T2891 |
T2890 |
punct |
],19 |
R2050 |
T2892 |
T2893 |
punct |
(,Figure |
R2051 |
T2893 |
T2869 |
parataxis |
Figure,identified |
R2052 |
T2894 |
T2893 |
nummod |
4,Figure |
R2053 |
T2895 |
T2893 |
punct |
),Figure |
R2054 |
T2896 |
T2869 |
punct |
.,identified |
R2055 |
T2898 |
T2899 |
nsubj |
We,designed |
R2056 |
T2900 |
T2899 |
dobj |
oligonucleotides,designed |
R2057 |
T2901 |
T2900 |
prep |
to,oligonucleotides |
R2058 |
T2902 |
T2903 |
amod |
non-coding,regions |
R2059 |
T2903 |
T2901 |
pobj |
regions,to |
R2060 |
T2904 |
T2903 |
acl |
flanking,regions |
R2061 |
T2905 |
T2906 |
det |
the,sequence |
R2062 |
T2906 |
T2904 |
dobj |
sequence,flanking |
R2063 |
T2907 |
T2906 |
compound |
coding,sequence |
R2064 |
T2908 |
T2906 |
prep |
of,sequence |
R2065 |
T2909 |
T2910 |
det |
each,Tas2r |
R2066 |
T2910 |
T2908 |
pobj |
Tas2r,of |
R2067 |
T2911 |
T2910 |
amod |
intact,Tas2r |
R2068 |
T2912 |
T2913 |
punct |
[,see |
R2069 |
T2913 |
T2899 |
parataxis |
see,designed |
R2070 |
T2914 |
T2915 |
amod |
Additional,file |
R2071 |
T2915 |
T2913 |
dobj |
file,see |
R2072 |
T2916 |
T2915 |
nummod |
2,file |
R2073 |
T2917 |
T2913 |
punct |
],see |
R2074 |
T2918 |
T2899 |
punct |
.,designed |
R2075 |
T2920 |
T2921 |
advcl |
Using,amplified |
R2076 |
T2922 |
T2923 |
det |
these,oligos |
R2077 |
T2923 |
T2920 |
dobj |
oligos,Using |
R2078 |
T2924 |
T2921 |
punct |
", ",amplified |
R2079 |
T2925 |
T2921 |
nsubj |
we,amplified |
R2080 |
T2926 |
T2927 |
det |
each,sequence |
R2081 |
T2927 |
T2921 |
dobj |
sequence,amplified |
R2082 |
T2928 |
T2927 |
compound |
Tas2r,sequence |
R2083 |
T2929 |
T2927 |
compound |
coding,sequence |
R2084 |
T2930 |
T2921 |
prep |
from,amplified |
R2085 |
T2931 |
T2932 |
nmod |
D2,DNA |
R2086 |
T2932 |
T2930 |
pobj |
DNA,from |
R2087 |
T2933 |
T2932 |
amod |
genomic,DNA |
R2088 |
T2934 |
T2921 |
punct |
.,amplified |
R2089 |
T2936 |
T2937 |
compound |
PCR,products |
R2090 |
T2937 |
T2938 |
nsubjpass |
products,subcloned |
R2091 |
T2939 |
T2938 |
auxpass |
were,subcloned |
R2092 |
T2940 |
T2938 |
prep |
into,subcloned |
R2093 |
T2941 |
T2942 |
compound |
cloning,vectors |
R2094 |
T2942 |
T2940 |
pobj |
vectors,into |
R2095 |
T2943 |
T2938 |
cc |
and,subcloned |
R2096 |
T2944 |
T2938 |
conj |
sequenced,subcloned |
R2097 |
T2945 |
T2938 |
punct |
.,subcloned |
R2098 |
T2947 |
T2948 |
nsubj |
Comparisons,revealed |
R2099 |
T2949 |
T2947 |
prep |
of,Comparisons |
R2100 |
T2950 |
T2951 |
det |
the,sequences |
R2101 |
T2951 |
T2949 |
pobj |
sequences,of |
R2102 |
T2952 |
T2951 |
prep |
of,sequences |
R2103 |
T2953 |
T2954 |
nmod |
B6,orthologues |
R2104 |
T2954 |
T2952 |
pobj |
orthologues,of |
R2105 |
T2955 |
T2953 |
cc |
and,B6 |
R2106 |
T2956 |
T2953 |
conj |
D2,B6 |
R2107 |
T2957 |
T2958 |
mark |
that,were |
R2108 |
T2958 |
T2948 |
ccomp |
were,revealed |
R2109 |
T2959 |
T2960 |
advmod |
only,two |
R2110 |
T2960 |
T2958 |
nsubj |
two,were |
R2111 |
T2961 |
T2960 |
prep |
of,two |
R2112 |
T2962 |
T2963 |
det |
the,alleles |
R2113 |
T2963 |
T2961 |
pobj |
alleles,of |
R2114 |
T2964 |
T2965 |
compound |
twenty,four |
R2115 |
T2965 |
T2963 |
nummod |
four,alleles |
R2116 |
T2966 |
T2965 |
punct |
-,four |
R2117 |
T2967 |
T2963 |
compound |
Tas2r,alleles |
R2118 |
T2968 |
T2963 |
acl |
examined,alleles |
R2119 |
T2969 |
T2960 |
punct |
", ",two |
R2120 |
T2970 |
T2960 |
appos |
Tas2r106,two |
R2121 |
T2971 |
T2970 |
cc |
and,Tas2r106 |
R2122 |
T2972 |
T2970 |
conj |
Tas2r124,Tas2r106 |
R2123 |
T2973 |
T2958 |
punct |
", ",were |
R2124 |
T2974 |
T2958 |
acomp |
identical,were |
R2125 |
T2975 |
T2958 |
prep |
across,were |
R2126 |
T2976 |
T2975 |
pobj |
strains,across |
R2127 |
T2977 |
T2958 |
prep |
at,were |
R2128 |
T2978 |
T2979 |
det |
the,level |
R2129 |
T2979 |
T2977 |
pobj |
level,at |
R2130 |
T2980 |
T2981 |
compound |
amino,acid |
R2131 |
T2981 |
T2979 |
compound |
acid,level |
R2132 |
T2982 |
T2983 |
punct |
(,shown |
R2133 |
T2983 |
T2958 |
parataxis |
shown,were |
R2134 |
T2984 |
T2983 |
nsubj |
data,shown |
R2135 |
T2985 |
T2983 |
neg |
not,shown |
R2136 |
T2986 |
T2983 |
punct |
),shown |
R2137 |
T2987 |
T2948 |
punct |
.,revealed |
R2138 |
T2989 |
T2990 |
det |
A,third |
R2139 |
T2990 |
T2991 |
nsubjpass |
third,amplified |
R2140 |
T2992 |
T2990 |
punct |
", ",third |
R2141 |
T2993 |
T2990 |
appos |
Tas2r120,third |
R2142 |
T2994 |
T2991 |
punct |
", ",amplified |
R2143 |
T2995 |
T2991 |
aux |
could,amplified |
R2144 |
T2996 |
T2991 |
neg |
not,amplified |
R2145 |
T2997 |
T2991 |
auxpass |
be,amplified |
R2146 |
T2998 |
T2991 |
prep |
from,amplified |
R2147 |
T2999 |
T3000 |
nmod |
D2,DNA |
R2148 |
T3000 |
T2998 |
pobj |
DNA,from |
R2149 |
T3001 |
T3000 |
amod |
genomic,DNA |
R2150 |
T3002 |
T3003 |
punct |
(,Figure |
R2151 |
T3003 |
T3000 |
parataxis |
Figure,DNA |
R2152 |
T3004 |
T3003 |
nummod |
5,Figure |
R2153 |
T3005 |
T3003 |
punct |
),Figure |
R2154 |
T3006 |
T2991 |
advcl |
using,amplified |
R2155 |
T3007 |
T3006 |
dobj |
either,using |
R2156 |
T3008 |
T3007 |
prep |
of,either |
R2157 |
T3009 |
T3010 |
nummod |
two,pairs |
R2158 |
T3010 |
T3008 |
pobj |
pairs,of |
R2159 |
T3011 |
T3010 |
prep |
of,pairs |
R2160 |
T3012 |
T3011 |
pobj |
oligonucleotides,of |
R2161 |
T3013 |
T3014 |
punct |
(,file |
R2162 |
T3014 |
T3006 |
parataxis |
file,using |
R2163 |
T3015 |
T3014 |
amod |
Additional,file |
R2164 |
T3016 |
T3014 |
nummod |
2,file |
R2165 |
T3017 |
T3014 |
punct |
),file |
R2166 |
T3018 |
T2991 |
punct |
", ",amplified |
R2167 |
T3019 |
T2991 |
advcl |
suggesting,amplified |
R2168 |
T3020 |
T3021 |
mark |
that,deleted |
R2169 |
T3021 |
T3019 |
ccomp |
deleted,suggesting |
R2170 |
T3022 |
T3023 |
det |
this,Tas2r |
R2171 |
T3023 |
T3021 |
nsubjpass |
Tas2r,deleted |
R2172 |
T3024 |
T3021 |
auxpass |
is,deleted |
R2173 |
T3025 |
T3021 |
prep |
in,deleted |
R2174 |
T3026 |
T3027 |
compound |
D2,mice |
R2175 |
T3027 |
T3025 |
pobj |
mice,in |
R2176 |
T3028 |
T2991 |
punct |
.,amplified |
R2177 |
T3030 |
T3031 |
nummod |
Two,alleles |
R2178 |
T3031 |
T3033 |
nsubj |
alleles,contained |
R2179 |
T3032 |
T3031 |
compound |
D2,alleles |
R2180 |
T3033 |
T3039 |
ccomp |
contained,be |
R2181 |
T3034 |
T3031 |
punct |
", ",alleles |
R2182 |
T3035 |
T3031 |
appos |
Tas2r103,alleles |
R2183 |
T3036 |
T3035 |
cc |
and,Tas2r103 |
R2184 |
T3037 |
T3035 |
conj |
Tas2r117,Tas2r103 |
R2185 |
T3038 |
T3033 |
punct |
", ",contained |
R2186 |
T3040 |
T3041 |
amod |
numerous,mutations |
R2187 |
T3041 |
T3033 |
dobj |
mutations,contained |
R2188 |
T3042 |
T3041 |
compound |
missense,mutations |
R2189 |
T3043 |
T3041 |
cc |
and,mutations |
R2190 |
T3044 |
T3045 |
amod |
small,deletions |
R2191 |
T3045 |
T3041 |
conj |
deletions,mutations |
R2192 |
T3046 |
T3047 |
dep |
that,create |
R2193 |
T3047 |
T3045 |
relcl |
create,deletions |
R2194 |
T3048 |
T3049 |
compound |
frame,shifts |
R2195 |
T3049 |
T3047 |
dobj |
shifts,create |
R2196 |
T3050 |
T3049 |
cc |
and,shifts |
R2197 |
T3051 |
T3052 |
amod |
premature,termination |
R2198 |
T3052 |
T3049 |
conj |
termination,shifts |
R2199 |
T3053 |
T3039 |
punct |
;,be |
R2200 |
T3054 |
T3055 |
det |
these,genes |
R2201 |
T3055 |
T3039 |
nsubj |
genes,be |
R2202 |
T3056 |
T3055 |
nummod |
two,genes |
R2203 |
T3057 |
T3039 |
aux |
may,be |
R2204 |
T3058 |
T3039 |
attr |
pseudogenes,be |
R2205 |
T3059 |
T3039 |
prep |
in,be |
R2206 |
T3060 |
T3061 |
det |
this,strain |
R2207 |
T3061 |
T3059 |
pobj |
strain,in |
R2208 |
T3062 |
T3039 |
punct |
.,be |
R2209 |
T3064 |
T3065 |
det |
The,Tas2rs |
R2210 |
T3065 |
T3068 |
nsubj |
Tas2rs,contained |
R2211 |
T3066 |
T3065 |
amod |
remaining,Tas2rs |
R2212 |
T3067 |
T3065 |
nummod |
19,Tas2rs |
R2213 |
T3069 |
T3070 |
quantmod |
between,one |
R2214 |
T3070 |
T3071 |
nummod |
one,mutations |
R2215 |
T3071 |
T3068 |
dobj |
mutations,contained |
R2216 |
T3072 |
T3070 |
cc |
and,one |
R2217 |
T3073 |
T3070 |
conj |
16,one |
R2218 |
T3074 |
T3071 |
compound |
missense,mutations |
R2219 |
T3075 |
T3068 |
punct |
.,contained |
R2220 |
T3077 |
T3078 |
det |
All,Tas2rs |
R2221 |
T3078 |
T3080 |
nsubj |
Tas2rs,have |
R2222 |
T3079 |
T3078 |
nummod |
24,Tas2rs |
R2223 |
T3081 |
T3078 |
acl |
examined,Tas2rs |
R2224 |
T3082 |
T3083 |
amod |
different,alleles |
R2225 |
T3083 |
T3080 |
dobj |
alleles,have |
R2226 |
T3084 |
T3080 |
prep |
in,have |
R2227 |
T3085 |
T3086 |
nmod |
B6,mice |
R2228 |
T3086 |
T3084 |
pobj |
mice,in |
R2229 |
T3087 |
T3085 |
cc |
and,B6 |
R2230 |
T3088 |
T3085 |
conj |
D2,B6 |
R2231 |
T3089 |
T3080 |
punct |
", ",have |
R2232 |
T3090 |
T3080 |
cc |
and,have |
R2233 |
T3091 |
T3092 |
nummod |
307,polymorphisms |
R2234 |
T3092 |
T3095 |
nsubj |
polymorphisms,are |
R2235 |
T3093 |
T3092 |
amod |
single,polymorphisms |
R2236 |
T3094 |
T3092 |
compound |
nucleotide,polymorphisms |
R2237 |
T3095 |
T3080 |
conj |
are,have |
R2238 |
T3096 |
T3095 |
acomp |
present,are |
R2239 |
T3097 |
T3095 |
prep |
within,are |
R2240 |
T3098 |
T3099 |
compound |
coding,exons |
R2241 |
T3099 |
T3097 |
pobj |
exons,within |
R2242 |
T3100 |
T3101 |
punct |
(,shown |
R2243 |
T3101 |
T3095 |
parataxis |
shown,are |
R2244 |
T3102 |
T3101 |
nsubj |
data,shown |
R2245 |
T3103 |
T3101 |
neg |
not,shown |
R2246 |
T3104 |
T3101 |
punct |
),shown |
R2247 |
T3105 |
T3095 |
punct |
.,are |
R2248 |
T3107 |
T3108 |
mark |
Although,found |
R2250 |
T3109 |
T3110 |
amod |
polymorphic,residues |
R2251 |
T3110 |
T3108 |
nsubjpass |
residues,found |
R2252 |
T3111 |
T3110 |
prep |
between,residues |
R2253 |
T3112 |
T3113 |
nmod |
B6,Tas2rs |
R2255 |
T3114 |
T3112 |
cc |
and,B6 |
R2256 |
T3115 |
T3112 |
conj |
D2,B6 |
R2326 |
T3195 |
T3193 |
nsubj |
we,proceeded |
R2327 |
T3196 |
T3197 |
aux |
to,screen |
R2328 |
T3197 |
T3193 |
xcomp |
screen,proceeded |
R2329 |
T3198 |
T3199 |
amod |
genomic,DNA |
R2330 |
T3199 |
T3197 |
dobj |
DNA,screen |
R2331 |
T3200 |
T3199 |
prep |
from,DNA |
R2332 |
T3201 |
T3202 |
nummod |
29,lines |
R2333 |
T3202 |
T3200 |
pobj |
lines,from |
R2334 |
T3203 |
T3202 |
amod |
available,lines |
R2335 |
T3204 |
T3202 |
nmod |
BXD,lines |
R2336 |
T3205 |
T3202 |
amod |
RI,lines |
R2337 |
T3206 |
T3202 |
punct |
", ",lines |
R2338 |
T3207 |
T3202 |
prep |
including,lines |
R2339 |
T3208 |
T3209 |
det |
the,17 |
R2340 |
T3209 |
T3207 |
pobj |
17,including |
R2341 |
T3210 |
T3211 |
dep |
that,used |
R2342 |
T3211 |
T3209 |
relcl |
used,17 |
R2343 |
T3212 |
T3211 |
nsubj |
we,used |
R2344 |
T3213 |
T3211 |
aux |
had,used |
R2345 |
T3214 |
T3211 |
prep |
in,used |
R2346 |
T3215 |
T3216 |
compound |
taste,testing |
R2347 |
T3216 |
T3214 |
pobj |
testing,in |
R2348 |
T3217 |
T3197 |
punct |
", ",screen |
R2349 |
T3218 |
T3197 |
prep |
for,screen |
R2350 |
T3219 |
T3220 |
det |
the,Tas2r |
R2351 |
T3220 |
T3218 |
pobj |
Tas2r,for |
R2352 |
T3221 |
T3220 |
nmod |
alleles,Tas2r |
R2353 |
T3222 |
T3223 |
nsubj |
they,contained |
R2354 |
T3223 |
T3220 |
advcl |
contained,Tas2r |
R2355 |
T3224 |
T3193 |
punct |
.,proceeded |
R2356 |
T3226 |
T3227 |
prep |
In,were |
R2357 |
T3228 |
T3229 |
amod |
most,cases |
R2358 |
T3229 |
T3226 |
pobj |
cases,In |
R2359 |
T3230 |
T3227 |
punct |
", ",were |
R2360 |
T3231 |
T3227 |
nsubj |
we,were |
R2361 |
T3232 |
T3227 |
acomp |
able,were |
R2362 |
T3233 |
T3234 |
aux |
to,identify |
R2363 |
T3234 |
T3232 |
xcomp |
identify,able |
R2364 |
T3235 |
T3236 |
amod |
diagnostic,digests |
R2365 |
T3236 |
T3234 |
dobj |
digests,identify |
R2366 |
T3237 |
T3236 |
compound |
restriction,digests |
R2367 |
T3238 |
T3236 |
compound |
endonuclease,digests |
R2368 |
T3239 |
T3240 |
dep |
that,allow |
R2369 |
T3240 |
T3236 |
relcl |
allow,digests |
R2370 |
T3241 |
T3240 |
aux |
would,allow |
R2371 |
T3242 |
T3243 |
nsubj |
us,identify |
R2372 |
T3243 |
T3240 |
ccomp |
identify,allow |
R2373 |
T3244 |
T3243 |
aux |
to,identify |
R2374 |
T3245 |
T3243 |
advmod |
quickly,identify |
R2375 |
T3246 |
T3247 |
mark |
whether,amplified |
R2376 |
T3247 |
T3243 |
ccomp |
amplified,identify |
R2377 |
T3248 |
T3249 |
det |
a,product |
R2378 |
T3249 |
T3247 |
nsubjpass |
product,amplified |
R2379 |
T3250 |
T3249 |
amod |
particular,product |
R2380 |
T3251 |
T3249 |
compound |
Tas2r,product |
R2381 |
T3252 |
T3249 |
compound |
PCR,product |
R2382 |
T3253 |
T3247 |
auxpass |
was,amplified |
R2383 |
T3254 |
T3247 |
prep |
from,amplified |
R2384 |
T3255 |
T3256 |
det |
a,allele |
R2385 |
T3256 |
T3254 |
pobj |
allele,from |
R2386 |
T3257 |
T3256 |
nmod |
B6,allele |
R2387 |
T3258 |
T3257 |
cc |
or,B6 |
R2388 |
T3259 |
T3257 |
conj |
D2,B6 |
R2389 |
T3260 |
T3227 |
punct |
.,were |
R2390 |
T3262 |
T3263 |
nsubj |
We,analyze |
R2391 |
T3264 |
T3263 |
aux |
did,analyze |
R2392 |
T3265 |
T3263 |
neg |
not,analyze |
R2393 |
T3266 |
T3267 |
nummod |
three,genes |
R2394 |
T3267 |
T3263 |
dobj |
genes,analyze |
R2395 |
T3268 |
T3267 |
punct |
(,genes |
R2396 |
T3269 |
T3267 |
appos |
Tas2r104,genes |
R2397 |
T3270 |
T3269 |
punct |
", ",Tas2r104 |
R2398 |
T3271 |
T3269 |
conj |
Tas2r114,Tas2r104 |
R2399 |
T3272 |
T3271 |
cc |
and,Tas2r114 |
R2400 |
T3273 |
T3271 |
conj |
Tas2r110,Tas2r114 |
R2401 |
T3274 |
T3267 |
punct |
),genes |
R2402 |
T3275 |
T3276 |
advmod |
where,identified |
R2403 |
T3276 |
T3267 |
relcl |
identified,genes |
R2404 |
T3277 |
T3278 |
det |
no,endonuclease |
R2405 |
T3278 |
T3276 |
nsubjpass |
endonuclease,identified |
R2406 |
T3279 |
T3278 |
amod |
diagnostic,endonuclease |
R2407 |
T3280 |
T3278 |
compound |
restriction,endonuclease |
R2408 |
T3281 |
T3276 |
aux |
could,identified |
R2409 |
T3282 |
T3276 |
auxpass |
be,identified |
R2410 |
T3283 |
T3263 |
punct |
.,analyze |
R2411 |
T3285 |
T3286 |
prep |
For,was |
R2412 |
T3287 |
T3285 |
pobj |
Tas2r120,For |
R2413 |
T3288 |
T3287 |
punct |
", ",Tas2r120 |
R2414 |
T3289 |
T3290 |
dep |
which,deleted |
R2415 |
T3290 |
T3287 |
relcl |
deleted,Tas2r120 |
R2416 |
T3291 |
T3290 |
auxpass |
is,deleted |
R2417 |
T3292 |
T3290 |
advmod |
likely,deleted |
R2418 |
T3293 |
T3290 |
prep |
in,deleted |
R2419 |
T3294 |
T3295 |
compound |
D2,mice |
R2420 |
T3295 |
T3293 |
pobj |
mice,in |
R2421 |
T3296 |
T3286 |
punct |
", ",was |
R2422 |
T3297 |
T3298 |
det |
the,absence |
R2423 |
T3298 |
T3286 |
nsubj |
absence,was |
R2424 |
T3299 |
T3298 |
prep |
of,absence |
R2425 |
T3300 |
T3301 |
det |
a,product |
R2426 |
T3301 |
T3299 |
pobj |
product,of |
R2427 |
T3302 |
T3301 |
compound |
PCR,product |
R2428 |
T3303 |
T3286 |
acomp |
diagnostic,was |
R2429 |
T3304 |
T3303 |
prep |
of,diagnostic |
R2430 |
T3305 |
T3306 |
det |
the,genotype |
R2431 |
T3306 |
T3304 |
pobj |
genotype,of |
R2432 |
T3307 |
T3306 |
compound |
D2,genotype |
R2433 |
T3308 |
T3306 |
prep |
for,genotype |
R2434 |
T3309 |
T3310 |
det |
this,gene |
R2435 |
T3310 |
T3308 |
pobj |
gene,for |
R2436 |
T3311 |
T3286 |
punct |
.,was |
R2437 |
T3313 |
T3314 |
advmod |
Surprisingly,discovered |
R2438 |
T3315 |
T3314 |
punct |
", ",discovered |
R2439 |
T3316 |
T3314 |
nsubj |
we,discovered |
R2440 |
T3317 |
T3318 |
mark |
that,been |
R2441 |
T3318 |
T3314 |
ccomp |
been,discovered |
R2442 |
T3319 |
T3318 |
expl |
there,been |
R2443 |
T3320 |
T3318 |
aux |
have,been |
R2444 |
T3321 |
T3322 |
det |
no,events |
R2445 |
T3322 |
T3318 |
attr |
events,been |
R2446 |
T3323 |
T3322 |
amod |
apparent,events |
R2447 |
T3324 |
T3322 |
compound |
recombination,events |
R2448 |
T3325 |
T3322 |
prep |
within,events |
R2449 |
T3326 |
T3327 |
det |
the,cluster |
R2450 |
T3327 |
T3325 |
pobj |
cluster,within |
R2451 |
T3328 |
T3327 |
amod |
distal,cluster |
R2452 |
T3329 |
T3327 |
nmod |
chromosome,cluster |
R2453 |
T3330 |
T3329 |
nummod |
6,chromosome |
R2454 |
T3331 |
T3318 |
prep |
during,been |
R2455 |
T3332 |
T3333 |
det |
the,generation |
R2456 |
T3333 |
T3331 |
pobj |
generation,during |
R2457 |
T3334 |
T3333 |
prep |
of,generation |
R2458 |
T3335 |
T3336 |
det |
the,lines |
R2459 |
T3336 |
T3334 |
pobj |
lines,of |
R2460 |
T3337 |
T3336 |
nmod |
BXD,lines |
R2461 |
T3338 |
T3336 |
amod |
RI,lines |
R2462 |
T3339 |
T3314 |
punct |
.,discovered |
R2463 |
T3341 |
T3342 |
prep |
For,originated |
R2464 |
T3343 |
T3344 |
det |
all,lines |
R2465 |
T3344 |
T3341 |
pobj |
lines,For |
R2466 |
T3345 |
T3344 |
amod |
RI,lines |
R2467 |
T3346 |
T3344 |
acl |
tested,lines |
R2468 |
T3347 |
T3342 |
punct |
", ",originated |
R2469 |
T3348 |
T3349 |
det |
every,Tas2r |
R2470 |
T3349 |
T3342 |
nsubj |
Tas2r,originated |
R2471 |
T3350 |
T3349 |
prep |
within,Tas2r |
R2472 |
T3351 |
T3352 |
det |
an,line |
R2473 |
T3352 |
T3350 |
pobj |
line,within |
R2474 |
T3353 |
T3352 |
amod |
individual,line |
R2475 |
T3354 |
T3352 |
amod |
RI,line |
R2476 |
T3355 |
T3342 |
prep |
from,originated |
R2477 |
T3356 |
T3357 |
det |
the,strain |
R2478 |
T3357 |
T3355 |
pobj |
strain,from |
R2479 |
T3358 |
T3357 |
amod |
same,strain |
R2480 |
T3359 |
T3357 |
amod |
parental,strain |
R2481 |
T3360 |
T3361 |
punct |
(,6 |
R2482 |
T3361 |
T3342 |
parataxis |
6,originated |
R2483 |
T3362 |
T3361 |
nmod |
Figures,6 |
R2484 |
T3363 |
T3361 |
nummod |
5,6 |
R2485 |
T3364 |
T3361 |
punct |
", ",6 |
R2486 |
T3365 |
T3361 |
punct |
),6 |
R2487 |
T3366 |
T3342 |
punct |
.,originated |
R2488 |
T3368 |
T3369 |
advmod |
Furthermore,correlated |
R2489 |
T3370 |
T3369 |
punct |
", ",correlated |
R2490 |
T3371 |
T3372 |
det |
the,genotype |
R2491 |
T3372 |
T3369 |
nsubj |
genotype,correlated |
R2492 |
T3373 |
T3372 |
prep |
of,genotype |
R2493 |
T3374 |
T3375 |
det |
each,gene |
R2494 |
T3375 |
T3373 |
pobj |
gene,of |
R2495 |
T3376 |
T3375 |
compound |
Tas2r,gene |
R2496 |
T3377 |
T3369 |
advmod |
always,correlated |
R2497 |
T3378 |
T3369 |
prep |
with,correlated |
R2498 |
T3379 |
T3380 |
det |
the,phenotype |
R2499 |
T3380 |
T3378 |
pobj |
phenotype,with |
R2500 |
T3381 |
T3380 |
compound |
QHCl,phenotype |
R2501 |
T3382 |
T3380 |
compound |
taste,phenotype |
R2502 |
T3383 |
T3384 |
punct |
(,7 |
R2503 |
T3384 |
T3369 |
parataxis |
7,correlated |
R2504 |
T3385 |
T3384 |
nmod |
Figures,7 |
R2505 |
T3386 |
T3384 |
nummod |
6,7 |
R2506 |
T3387 |
T3384 |
punct |
", ",7 |
R2507 |
T3388 |
T3384 |
punct |
),7 |
R2508 |
T3389 |
T3369 |
punct |
", ",correlated |
R2509 |
T3390 |
T3369 |
advcl |
suggesting,correlated |
R2510 |
T3391 |
T3392 |
mark |
that,is |
R2511 |
T3392 |
T3390 |
ccomp |
is,suggesting |
R2512 |
T3393 |
T3394 |
det |
the,cluster |
R2513 |
T3394 |
T3392 |
nsubj |
cluster,is |
R2514 |
T3395 |
T3394 |
amod |
entire,cluster |
R2515 |
T3396 |
T3394 |
compound |
Tas2r,cluster |
R2516 |
T3397 |
T3398 |
det |
a,haplotype |
R2517 |
T3398 |
T3392 |
attr |
haplotype,is |
R2518 |
T3399 |
T3398 |
amod |
single,haplotype |
R2519 |
T3400 |
T3401 |
dep |
that,varies |
R2520 |
T3401 |
T3398 |
relcl |
varies,haplotype |
R2521 |
T3402 |
T3401 |
prep |
with,varies |
R2522 |
T3403 |
T3404 |
compound |
QHCl,taster |
R2523 |
T3404 |
T3405 |
compound |
taster,status |
R2524 |
T3405 |
T3402 |
pobj |
status,with |
R2525 |
T3406 |
T3369 |
punct |
.,correlated |
R2249 |
T3108 |
T3117 |
advcl |
found,are |
R2254 |
T3113 |
T3111 |
pobj |
Tas2rs,between |
R2257 |
T3116 |
T3108 |
auxpass |
are,found |
R2258 |
T3118 |
T3108 |
prep |
in,found |
R2259 |
T3119 |
T3120 |
det |
all,regions |
R2260 |
T3120 |
T3118 |
pobj |
regions,in |
R2261 |
T3121 |
T3120 |
prep |
of,regions |
R2262 |
T3122 |
T3123 |
det |
the,receptors |
R2263 |
T3123 |
T3121 |
pobj |
receptors,of |
R2264 |
T3124 |
T3117 |
punct |
", ",are |
R2265 |
T3125 |
T3126 |
nummod |
23,% |
R2266 |
T3126 |
T3117 |
nsubj |
%,are |
R2267 |
T3127 |
T3126 |
prep |
of,% |
R2268 |
T3128 |
T3129 |
det |
the,changes |
R2269 |
T3129 |
T3127 |
pobj |
changes,of |
R2270 |
T3130 |
T3131 |
compound |
amino,acid |
R2271 |
T3131 |
T3129 |
compound |
acid,changes |
R2272 |
T3132 |
T3129 |
acl |
seen,changes |
R2273 |
T3133 |
T3117 |
prep |
within,are |
R2274 |
T3134 |
T3135 |
det |
the,loops |
R2275 |
T3135 |
T3133 |
pobj |
loops,within |
R2276 |
T3136 |
T3135 |
amod |
first,loops |
R2277 |
T3137 |
T3135 |
nummod |
two,loops |
R2278 |
T3138 |
T3135 |
amod |
extracellular,loops |
R2279 |
T3139 |
T3135 |
prep |
of,loops |
R2280 |
T3140 |
T3141 |
det |
the,T2Rs |
R2281 |
T3141 |
T3139 |
pobj |
T2Rs,of |
R2282 |
T3142 |
T3143 |
punct |
(,shown |
R2283 |
T3143 |
T3117 |
parataxis |
shown,are |
R2284 |
T3144 |
T3143 |
nsubj |
data,shown |
R2285 |
T3145 |
T3143 |
neg |
not,shown |
R2286 |
T3146 |
T3143 |
punct |
),shown |
R2287 |
T3147 |
T3117 |
punct |
.,are |
R2288 |
T3154 |
T3155 |
nsubj |
variability,suggested |
R2289 |
T3156 |
T3154 |
prep |
between,variability |
R2290 |
T3157 |
T3158 |
amod |
orthologous,receptors |
R2291 |
T3158 |
T3156 |
pobj |
receptors,between |
R2292 |
T3159 |
T3154 |
prep |
in,variability |
R2293 |
T3160 |
T3161 |
det |
these,strains |
R2294 |
T3161 |
T3159 |
pobj |
strains,in |
R2295 |
T3162 |
T3161 |
nummod |
two,strains |
R2296 |
T3163 |
T3161 |
amod |
inbred,strains |
R2297 |
T3164 |
T3165 |
mark |
that,be |
R2298 |
T3165 |
T3155 |
ccomp |
be,suggested |
R2299 |
T3166 |
T3165 |
nsubj |
it,be |
R2300 |
T3167 |
T3165 |
aux |
might,be |
R2301 |
T3168 |
T3165 |
acomp |
possible,be |
R2302 |
T3169 |
T3170 |
aux |
to,narrow |
R2303 |
T3170 |
T3165 |
xcomp |
narrow,be |
R2304 |
T3171 |
T3172 |
det |
the,boundaries |
R2305 |
T3172 |
T3170 |
dobj |
boundaries,narrow |
R2306 |
T3173 |
T3172 |
amod |
physical,boundaries |
R2307 |
T3174 |
T3172 |
prep |
of,boundaries |
R2308 |
T3175 |
T3176 |
det |
the,QTL |
R2309 |
T3176 |
T3174 |
pobj |
QTL,of |
R2310 |
T3177 |
T3178 |
compound |
QHCl,taste |
R2311 |
T3178 |
T3176 |
compound |
taste,QTL |
R2312 |
T3179 |
T3170 |
prep |
by,narrow |
R2313 |
T3180 |
T3179 |
pcomp |
determining,by |
R2314 |
T3181 |
T3182 |
det |
which,alleles |
R2315 |
T3182 |
T3184 |
dep |
alleles,correlated |
R2316 |
T3183 |
T3182 |
compound |
Tas2r,alleles |
R2317 |
T3184 |
T3180 |
ccomp |
correlated,determining |
R2318 |
T3185 |
T3184 |
auxpass |
are,correlated |
R2319 |
T3186 |
T3184 |
prep |
with,correlated |
R2320 |
T3187 |
T3188 |
compound |
QHCl,taste |
R2321 |
T3188 |
T3189 |
compound |
taste,sensitivity |
R2322 |
T3189 |
T3186 |
pobj |
sensitivity,with |
R2323 |
T3190 |
T3155 |
punct |
.,suggested |
R2324 |
T3192 |
T3193 |
advmod |
Therefore,proceeded |
R2325 |
T3194 |
T3193 |
punct |
", ",proceeded |