PMC:1166548 / 19494-20141 JSONTXT

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    craft-sa-dev

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    craft-ca-core-dev

    {"project":"craft-ca-core-dev","denotations":[{"id":"T3959","span":{"begin":619,"end":625},"obj":"SO:0001026"},{"id":"T3958","span":{"begin":613,"end":618},"obj":"NCBITaxon:10088"},{"id":"T3957","span":{"begin":589,"end":593},"obj":"SO:0000704"},{"id":"T3956","span":{"begin":562,"end":567},"obj":"PR:000000782"},{"id":"T3955","span":{"begin":536,"end":541},"obj":"PR:000002005"},{"id":"T3954","span":{"begin":511,"end":517},"obj":"PR:000001979"},{"id":"T3953","span":{"begin":487,"end":492},"obj":"PR:000002004"},{"id":"T3952","span":{"begin":470,"end":485},"obj":"GO:0042044"},{"id":"T3951","span":{"begin":470,"end":475},"obj":"UBERON:0006314"},{"id":"T3950","span":{"begin":392,"end":397},"obj":"SO:0000704"},{"id":"T3949","span":{"begin":269,"end":273},"obj":"PR:000001044"},{"id":"T3948","span":{"begin":213,"end":221},"obj":"CHEBI:17996"},{"id":"T3947","span":{"begin":173,"end":183},"obj":"UBERON:0000160"},{"id":"T3946","span":{"begin":53,"end":58},"obj":"SO:0000704"},{"id":"T3945","span":{"begin":2,"end":3},"obj":"NCBITaxon:10088"},{"id":"T3944","span":{"begin":1,"end":2},"obj":"SO:0001023"}],"text":"Because the spacing of markers used was about 12 cM, genes within 75% of this interval on either side of the markers were looked at for potential relevance to the milder CF intestinal phenotype. None of the known chloride channels that might substitute for the missing CFTR are in the regions of the three chromosomes associated with the milder phenotype. There are several potassium channel genes in the identified regions that potentially could affect electrolyte and fluid transport: Kcnj9 (chr.1, 94.2 cM), Kcnj10 (chr.1, 93.5 cM), Kcnj5 (chr.9, 11 cM), and Kcnc2 (chr.10, 62 cM). All gene names are from the Mouse Genome Informatics website ."}