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PMC:1166548 / 1664-2866 JSONTXT

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Id Subject Object Predicate Lexical cue
T453 0-2 TO denotes to
T454 18-28 VBN denotes associated
T455 3-5 VB denotes be
T456 6-17 RB denotes potentially
T457 29-33 IN denotes with
T458 34-37 DT denotes the
T459 45-54 NN denotes phenotype
T460 38-44 JJR denotes milder
T461 54-55 . denotes .
T462 55-185 sentence denotes One on chr.1, defined by marker D1Mit36, one on chr. 9 defined by marker D9Mit90, and one on chr. 10, defined by marker D10Mit14.
T463 56-59 CD denotes One
T464 60-62 IN denotes on
T465 63-68 NN denotes chr.1
T466 68-70 , denotes ,
T467 70-77 VBN denotes defined
T468 78-80 IN denotes by
T469 81-87 NN denotes marker
T470 88-95 NN denotes D1Mit36
T471 95-97 , denotes ,
T472 97-100 CD denotes one
T473 101-103 IN denotes on
T474 104-108 NN denotes chr.
T475 109-110 CD denotes 9
T476 111-118 VBN denotes defined
T477 119-121 IN denotes by
T478 122-128 NN denotes marker
T479 129-136 NN denotes D9Mit90
T480 136-138 , denotes ,
T481 138-141 CC denotes and
T482 142-145 CD denotes one
T483 146-148 IN denotes on
T484 149-153 NN denotes chr.
T485 154-156 CD denotes 10
T486 156-158 , denotes ,
T487 158-165 VBN denotes defined
T488 166-168 IN denotes by
T489 169-175 NN denotes marker
T490 176-184 NN denotes D10Mit14
T491 184-185 . denotes .
T492 185-197 sentence denotes Conclusion
T493 187-197 NN denotes Conclusion
T494 197-346 sentence denotes Potential modifier regions were found that have a positive impact on the inflammatory phenotype of the CF mouse small intestine and animal survival.
T495 198-207 JJ denotes Potential
T496 217-224 NNS denotes regions
T497 208-216 NN denotes modifier
T498 230-235 VBN denotes found
T499 225-229 VBD denotes were
T500 236-240 WDT denotes that
T501 241-245 VBP denotes have
T502 246-247 DT denotes a
T503 257-263 NN denotes impact
T504 248-256 JJ denotes positive
T505 264-266 IN denotes on
T506 267-270 DT denotes the
T507 284-293 NN denotes phenotype
T508 271-283 JJ denotes inflammatory
T509 294-296 IN denotes of
T510 297-300 DT denotes the
T511 316-325 NN denotes intestine
T512 301-303 NN denotes CF
T513 304-309 NN denotes mouse
T514 310-315 JJ denotes small
T515 326-329 CC denotes and
T516 330-336 NN denotes animal
T517 337-345 NN denotes survival
T518 345-346 . denotes .
T519 346-510 sentence denotes Identification of polymorphisms in specific genes in these regions should provide important new information about genetic modifiers of the CF intestinal phenotype.
T520 347-361 NN denotes Identification
T521 421-428 VB denotes provide
T522 362-364 IN denotes of
T523 365-378 NNS denotes polymorphisms
T524 379-381 IN denotes in
T525 382-390 JJ denotes specific
T526 391-396 NNS denotes genes
T527 397-399 IN denotes in
T528 400-405 DT denotes these
T529 406-413 NNS denotes regions
T530 414-420 MD denotes should
T531 429-438 JJ denotes important
T532 443-454 NN denotes information
T533 439-442 JJ denotes new
T534 455-460 IN denotes about
T535 461-468 JJ denotes genetic
T536 469-478 NNS denotes modifiers
T537 479-481 IN denotes of
T538 482-485 DT denotes the
T539 500-509 NN denotes phenotype
T540 486-488 NN denotes CF
T541 489-499 JJ denotes intestinal
T542 509-510 . denotes .
T795 567-569 IN denotes in
T796 570-573 DT denotes the
T797 633-637 NN denotes gene
T798 574-580 JJ denotes cystic
T799 581-589 NN denotes fibrosis
T800 616-625 NN denotes regulator
T801 590-603 JJ denotes transmembrane
T802 604-615 NN denotes conductance
T803 626-627 -LRB- denotes (
T804 627-631 NN denotes CFTR
T805 631-632 -RRB- denotes )
T806 638-639 -LRB- denotes [
T807 639-640 CD denotes 1
T808 640-641 -RRB- denotes ]
T809 641-642 . denotes .
T810 642-791 sentence denotes Different mutations have a range of effects on the levels of CFTR protein and its proper functioning in epithelial transport of Cl- and HCO3- [2,3].
T811 643-652 JJ denotes Different
T812 653-662 NNS denotes mutations
T813 663-667 VBP denotes have
T814 668-669 DT denotes a
T815 670-675 NN denotes range
T816 676-678 IN denotes of
T817 679-686 NNS denotes effects
T818 687-689 IN denotes on
T819 690-693 DT denotes the
T820 694-700 NNS denotes levels
T821 701-703 IN denotes of
T822 704-708 NN denotes CFTR
T823 709-716 NN denotes protein
T824 717-720 CC denotes and
T825 721-724 PRP$ denotes its
T826 732-743 NN denotes functioning
T827 725-731 JJ denotes proper
T828 744-746 IN denotes in
T829 747-757 JJ denotes epithelial
T830 758-767 NN denotes transport
T831 768-770 IN denotes of
T832 771-773 NN denotes Cl
T833 773-774 SYM denotes -
T834 775-778 CC denotes and
T835 779-783 NN denotes HCO3
T836 783-784 SYM denotes -
T837 785-786 -LRB- denotes [
T838 788-789 CD denotes 3
T839 786-787 CD denotes 2
T840 787-788 , denotes ,
T841 789-790 -RRB- denotes ]
T842 790-791 . denotes .
T843 791-935 sentence denotes The severity of the pancreatic phenotype in human CF is well correlated with the extent of impaired CFTR function caused by specific mutations.
T844 792-795 DT denotes The
T845 796-804 NN denotes severity
T846 845-847 VBZ denotes is
T847 805-807 IN denotes of
T848 808-811 DT denotes the
T849 823-832 NN denotes phenotype
T850 812-822 JJ denotes pancreatic
T851 833-835 IN denotes in
T852 836-841 JJ denotes human
T853 842-844 NN denotes CF
T854 848-852 RB denotes well
T855 853-863 JJ denotes correlated
T856 864-868 IN denotes with
T857 869-872 DT denotes the
T858 873-879 NN denotes extent
T859 880-882 IN denotes of
T860 883-891 JJ denotes impaired
T861 897-905 NN denotes function
T862 892-896 NN denotes CFTR
T863 906-912 VBN denotes caused
T864 913-915 IN denotes by
T865 916-924 JJ denotes specific
T866 925-934 NNS denotes mutations
T867 934-935 . denotes .
T868 935-1042 sentence denotes Loss of CFTR function results in destruction of the exocrine tissue and eventual pancreatic insufficiency.
T869 936-940 NN denotes Loss
T870 958-965 VBZ denotes results
T871 941-943 IN denotes of
T872 944-948 NN denotes CFTR
T873 949-957 NN denotes function
T874 966-968 IN denotes in
T875 969-980 NN denotes destruction
T876 981-983 IN denotes of
T877 984-987 DT denotes the
T878 997-1003 NN denotes tissue
T879 988-996 NN denotes exocrine
T880 1004-1007 CC denotes and
T881 1008-1016 JJ denotes eventual
T882 1028-1041 NN denotes insufficiency
T883 1017-1027 JJ denotes pancreatic
T884 1041-1042 . denotes .
T886 1043-1045 IN denotes On
T887 1127-1129 VBZ denotes is
T888 1046-1049 DT denotes the
T889 1056-1060 NN denotes hand
T890 1050-1055 JJ denotes other
T891 1060-1062 , denotes ,
T892 1062-1065 DT denotes the
T893 1066-1073 NNS denotes effects
T894 1074-1076 IN denotes of
T895 1077-1079 NN denotes CF
T896 1080-1082 IN denotes on
T897 1083-1089 NNS denotes organs
T898 1090-1099 VBG denotes including
T899 1100-1103 DT denotes the
T900 1104-1111 NNS denotes airways
T901 1112-1115 CC denotes and
T902 1116-1126 NNS denotes intestines
T903 1130-1134 RBR denotes less
T904 1140-1150 JJ denotes correlated
T905 1135-1139 RB denotes well
T906 1151-1155 IN denotes with
T907 1156-1164 JJ denotes specific
T908 1170-1179 NNS denotes mutations
T909 1165-1169 NN denotes CFTR
T910 1180-1183 CC denotes and
T911 1184-1189 PRP$ denotes their
T912 1190-1197 NNS denotes effects
T913 1198-1200 IN denotes on
T786 523-529 JJ denotes Cystic
T787 530-538 NN denotes fibrosis
T788 547-553 VBN denotes caused
T789 539-540 -LRB- denotes (
T790 540-542 NN denotes CF
T791 542-543 -RRB- denotes )
T792 544-546 VBZ denotes is
T793 554-556 IN denotes by
T794 557-566 NNS denotes mutations
R289 T453 T454 aux to,associated
R293 T457 T454 prep with,associated
R294 T458 T459 det the,phenotype
R295 T459 T457 pobj phenotype,with
R298 T464 T463 prep on,One
R299 T465 T464 pobj chr.1,on
R300 T466 T463 punct ", ",One
R301 T467 T463 acl defined,One
R302 T468 T467 prep by,defined
R303 T469 T470 compound marker,D1Mit36
R304 T470 T468 pobj D1Mit36,by
R305 T471 T463 punct ", ",One
R306 T472 T463 conj one,One
R307 T473 T472 prep on,one
R308 T474 T473 pobj chr.,on
R309 T475 T474 nummod 9,chr.
R310 T476 T472 acl defined,one
R311 T477 T476 prep by,defined
R312 T478 T479 compound marker,D9Mit90
R313 T479 T477 pobj D9Mit90,by
R314 T480 T472 punct ", ",one
R315 T481 T472 cc and,one
R316 T482 T472 conj one,one
R317 T483 T482 prep on,one
R318 T484 T483 pobj chr.,on
R319 T485 T484 nummod 10,chr.
R320 T486 T482 punct ", ",one
R321 T487 T482 acl defined,one
R322 T488 T487 prep by,defined
R323 T489 T490 compound marker,D10Mit14
R324 T490 T488 pobj D10Mit14,by
R325 T491 T482 punct .,one
R326 T495 T496 amod Potential,regions
R327 T496 T498 nsubjpass regions,found
R329 T499 T498 auxpass were,found
R330 T500 T501 dep that,have
R331 T501 T498 ccomp have,found
R332 T502 T503 det a,impact
R333 T503 T501 dobj impact,have
R335 T505 T501 prep on,have
R336 T506 T507 det the,phenotype
R337 T507 T505 pobj phenotype,on
R339 T509 T507 prep of,phenotype
R340 T510 T511 det the,intestine
R341 T511 T509 pobj intestine,of
R345 T515 T507 cc and,phenotype
R346 T516 T517 compound animal,survival
R347 T517 T507 conj survival,phenotype
R348 T518 T498 punct .,found
R349 T520 T521 nsubj Identification,provide
R350 T522 T520 prep of,Identification
R351 T523 T522 pobj polymorphisms,of
R352 T524 T520 prep in,Identification
R353 T525 T526 amod specific,genes
R354 T526 T524 pobj genes,in
R355 T527 T526 prep in,genes
R356 T528 T529 det these,regions
R357 T529 T527 pobj regions,in
R358 T530 T521 aux should,provide
R359 T531 T532 amod important,information
R360 T532 T521 dobj information,provide
R362 T534 T532 prep about,information
R363 T535 T536 amod genetic,modifiers
R364 T536 T534 pobj modifiers,about
R365 T537 T536 prep of,modifiers
R366 T538 T539 det the,phenotype
R367 T539 T537 pobj phenotype,of
R370 T542 T521 punct .,provide
R394 T802 T800 nmod conductance,regulator
R395 T803 T800 punct (,regulator
R396 T804 T800 appos CFTR,regulator
R397 T805 T797 punct ),gene
R398 T806 T807 punct [,1
R399 T807 T788 parataxis 1,caused
R400 T808 T807 punct ],1
R401 T809 T788 punct .,caused
R402 T811 T812 amod Different,mutations
R403 T812 T813 nsubj mutations,have
R404 T814 T815 det a,range
R405 T815 T813 dobj range,have
R406 T816 T815 prep of,range
R407 T817 T816 pobj effects,of
R408 T818 T817 prep on,effects
R409 T819 T820 det the,levels
R410 T820 T818 pobj levels,on
R411 T821 T820 prep of,levels
R412 T822 T823 compound CFTR,protein
R413 T823 T821 pobj protein,of
R414 T824 T820 cc and,levels
R415 T825 T826 poss its,functioning
R416 T826 T820 conj functioning,levels
R417 T827 T826 amod proper,functioning
R418 T828 T826 prep in,functioning
R419 T829 T830 amod epithelial,transport
R420 T830 T828 pobj transport,in
R421 T831 T830 prep of,transport
R422 T832 T831 pobj Cl,of
R423 T833 T832 punct -,Cl
R424 T834 T832 cc and,Cl
R425 T835 T832 conj HCO3,Cl
R426 T836 T835 punct -,HCO3
R427 T837 T838 punct [,3
R428 T838 T813 parataxis 3,have
R429 T839 T838 nummod 2,3
R430 T840 T838 punct ",",3
R431 T841 T838 punct ],3
R432 T842 T813 punct .,have
R433 T844 T845 det The,severity
R434 T845 T846 nsubj severity,is
R435 T847 T845 prep of,severity
R436 T848 T849 det the,phenotype
R437 T849 T847 pobj phenotype,of
R438 T850 T849 amod pancreatic,phenotype
R439 T851 T845 prep in,severity
R440 T852 T853 amod human,CF
R441 T853 T851 pobj CF,in
R442 T854 T855 advmod well,correlated
R443 T855 T846 acomp correlated,is
R444 T856 T855 prep with,correlated
R445 T857 T858 det the,extent
R446 T858 T856 pobj extent,with
R447 T859 T858 prep of,extent
R448 T860 T861 amod impaired,function
R449 T861 T859 pobj function,of
R450 T862 T861 compound CFTR,function
R451 T863 T861 acl caused,function
R452 T864 T863 prep by,caused
R453 T865 T866 amod specific,mutations
R454 T866 T864 pobj mutations,by
R455 T867 T846 punct .,is
R456 T869 T870 nsubj Loss,results
R457 T871 T869 prep of,Loss
R458 T872 T873 compound CFTR,function
R459 T873 T871 pobj function,of
R460 T874 T870 prep in,results
R461 T875 T874 pobj destruction,in
R462 T876 T875 prep of,destruction
R463 T877 T878 det the,tissue
R464 T878 T876 pobj tissue,of
R465 T879 T878 compound exocrine,tissue
R466 T880 T878 cc and,tissue
R467 T881 T882 amod eventual,insufficiency
R468 T882 T878 conj insufficiency,tissue
R469 T883 T882 amod pancreatic,insufficiency
R470 T884 T870 punct .,results
R471 T886 T887 prep On,is
R472 T888 T889 det the,hand
R473 T889 T886 pobj hand,On
R474 T890 T889 amod other,hand
R475 T891 T887 punct ", ",is
R476 T892 T893 det the,effects
R477 T893 T887 nsubj effects,is
R478 T894 T893 prep of,effects
R479 T895 T894 pobj CF,of
R480 T896 T893 prep on,effects
R481 T897 T896 pobj organs,on
R482 T898 T897 prep including,organs
R483 T899 T900 det the,airways
R484 T900 T898 pobj airways,including
R485 T901 T900 cc and,airways
R486 T902 T900 conj intestines,airways
R487 T903 T904 advmod less,correlated
R488 T904 T887 acomp correlated,is
R489 T905 T904 advmod well,correlated
R490 T906 T904 prep with,correlated
R491 T907 T908 amod specific,mutations
R492 T908 T906 pobj mutations,with
R493 T909 T908 compound CFTR,mutations
R494 T910 T908 cc and,mutations
R495 T911 T912 poss their,effects
R496 T912 T908 conj effects,mutations
R497 T913 T912 prep on,effects
R291 T455 T454 auxpass be,associated
R292 T456 T454 advmod potentially,associated
R296 T460 T459 amod milder,phenotype
R328 T497 T496 compound modifier,regions
R334 T504 T503 amod positive,impact
R338 T508 T507 amod inflammatory,phenotype
R342 T512 T513 nmod CF,mouse
R343 T513 T511 nmod mouse,intestine
R344 T514 T511 amod small,intestine
R361 T533 T532 amod new,information
R368 T540 T539 nmod CF,phenotype
R369 T541 T539 amod intestinal,phenotype
R379 T786 T787 amod Cystic,fibrosis
R380 T787 T788 nsubjpass fibrosis,caused
R381 T789 T787 punct (,fibrosis
R382 T790 T787 appos CF,fibrosis
R383 T791 T788 punct ),caused
R384 T792 T788 auxpass is,caused
R385 T793 T788 agent by,caused
R386 T794 T793 pobj mutations,by
R387 T795 T794 prep in,mutations
R388 T796 T797 det the,gene
R389 T797 T795 pobj gene,in
R390 T798 T799 amod cystic,fibrosis
R391 T799 T800 nmod fibrosis,regulator
R392 T800 T797 nmod regulator,gene
R393 T801 T802 amod transmembrane,conductance

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T702 997-1003 UBERON:0000479 denotes tissue
T703 1017-1027 UBERON:0001264 denotes pancreatic
T704 1083-1089 UBERON:0000062 denotes organs
T705 1104-1111 UBERON:0001005 denotes airways
T706 1116-1126 UBERON:0000160 denotes intestines
T707 1165-1169 PR_EXT:000001044 denotes CFTR
T708 1170-1179 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T125 63-67 GO_SO_EXT:chromosome denotes chr.
T126 81-87 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T127 104-108 GO_SO_EXT:chromosome denotes chr.
T128 122-128 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T129 149-153 GO_SO_EXT:chromosome denotes chr.
T130 169-175 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T131 271-283 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T132 304-309 NCBITaxon:10088 denotes mouse
T133 310-325 UBERON:0002108 denotes small intestine
T134 330-336 NCBITaxon:33208 denotes animal
T135 365-378 SO_EXT:polymorphism denotes polymorphisms
T136 391-396 SO_EXT:0000704 denotes genes
T137 461-468 SO_EXT:0000704 denotes genetic
T138 489-499 UBERON:0000160 denotes intestinal
T678 557-566 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T679 574-625 PR_EXT:000001044 denotes cystic fibrosis transmembrane conductance regulator
T680 590-615 GO:0055085 denotes transmembrane conductance
T681 595-603 GO:0016020 denotes membrane
T682 616-625 GO_EXT:regulator denotes regulator
T683 627-631 PR_EXT:000001044 denotes CFTR
T684 633-637 SO_EXT:0000704 denotes gene
T685 653-662 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T686 704-708 PR_EXT:000001044 denotes CFTR
T687 709-716 CHEBI_PR_EXT:protein denotes protein
T688 747-757 UBERON:0000483 denotes epithelial
T689 758-774 GO:0006821 denotes transport of Cl-
T690 758-770 _FRAGMENT denotes transport of
T691 779-784 GO:0015701 denotes HCO3-
T692 771-774 CHEBI:17996 denotes Cl-
T693 779-784 CHEBI:17544 denotes HCO3-
T694 812-822 UBERON:0001264 denotes pancreatic
T695 836-841 NCBITaxon:9606 denotes human
T696 892-896 PR_EXT:000001044 denotes CFTR
T697 925-934 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T698 944-948 PR_EXT:000001044 denotes CFTR
T699 969-983 _FRAGMENT denotes destruction of
T700 997-1003 GO:0016271 denotes tissue
T701 988-996 UBERON:0002330 denotes exocrine
R374 T691 T690 _lexicallyChainedTo HCO3-,transport of
R375 T700 T699 _lexicallyChainedTo tissue,destruction of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T610 812-822 UBERON:0001264 denotes pancreatic
T611 836-841 NCBITaxon:9606 denotes human
T612 892-896 PR:000001044 denotes CFTR
T613 944-948 PR:000001044 denotes CFTR
T614 969-983 _FRAGMENT denotes destruction of
T615 997-1003 GO:0016271 denotes tissue
T616 988-996 UBERON:0002330 denotes exocrine
T617 997-1003 UBERON:0000479 denotes tissue
T618 1017-1027 UBERON:0001264 denotes pancreatic
T619 1083-1089 UBERON:0000062 denotes organs
T620 1104-1111 UBERON:0001005 denotes airways
T621 1116-1126 UBERON:0000160 denotes intestines
T622 1165-1169 PR:000001044 denotes CFTR
T68 304-309 NCBITaxon:10088 denotes mouse
T69 310-325 UBERON:0002108 denotes small intestine
T70 330-336 NCBITaxon:33208 denotes animal
T71 391-396 SO:0000704 denotes genes
T72 461-468 SO:0000704 denotes genetic
T73 489-499 UBERON:0000160 denotes intestinal
T598 574-625 PR:000001044 denotes cystic fibrosis transmembrane conductance regulator
T599 590-615 GO:0055085 denotes transmembrane conductance
T600 595-603 GO:0016020 denotes membrane
T601 627-631 PR:000001044 denotes CFTR
T602 633-637 SO:0000704 denotes gene
T603 704-708 PR:000001044 denotes CFTR
T604 747-757 UBERON:0000483 denotes epithelial
T605 758-774 GO:0006821 denotes transport of Cl-
T606 758-770 _FRAGMENT denotes transport of
T607 779-784 GO:0015701 denotes HCO3-
T608 771-774 CHEBI:17996 denotes Cl-
T609 779-784 CHEBI:17544 denotes HCO3-
R372 T607 T606 _lexicallyChainedTo HCO3-,transport of
R373 T615 T614 _lexicallyChainedTo tissue,destruction of