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though our RFP transgenic ES cell lines failed to maintain strong uniform expression with in vitro passage, we selected three lines exhibiting the most robust expression for making chimeras, in order to ascertain whether we could achieve, or possibly recover, RFP expression in animals. Cells were flow sorted prior to aggregation so as to enrich for RFP expression. Even though they had lost their characteristic ES cell morphology all three RFP+ ES cell lines went gemline as detected by coat color and PCR for the DsRed1 transgene (data not shown). However expression of the RFP reporter could not be detected in any organ of adult mice nor in embryos (data not shown). This suggests that the DsRed1 RFP reporter was unable to recapitulate the expression profile of the promoter/enhancer combination employed. Therefore it appears that GFP variant reporters are more versatile with respect to their application in mice."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T1368","span":{"begin":634,"end":639},"obj":"UBERON:0007023"},{"id":"T1369","span":{"begin":640,"end":644},"obj":"NCBITaxon:10088"},{"id":"T1370","span":{"begin":652,"end":659},"obj":"UBERON:0000922"},{"id":"T1371","span":{"begin":752,"end":762},"obj":"GO:0010467"},{"id":"T1372","span":{"begin":778,"end":786},"obj":"SO_EXT:0000167"},{"id":"T1373","span":{"begin":787,"end":795},"obj":"SO_EXT:0000165"},{"id":"T1374","span":{"begin":848,"end":855},"obj":"SO_EXT:sequence_variant_or_variation"},{"id":"T1375","span":{"begin":922,"end":926},"obj":"NCBITaxon:10088"},{"id":"T1351","span":{"begin":20,"end":30},"obj":"SO_EXT:transgenic_entity"},{"id":"T1352","span":{"begin":31,"end":38},"obj":"CL:0002322"},{"id":"T1353","span":{"begin":34,"end":38},"obj":"CL_GO_EXT:cell"},{"id":"T1354","span":{"begin":79,"end":89},"obj":"GO:0010467"},{"id":"T1355","span":{"begin":164,"end":174},"obj":"GO:0010467"},{"id":"T1356","span":{"begin":269,"end":279},"obj":"GO:0010467"},{"id":"T1357","span":{"begin":283,"end":290},"obj":"NCBITaxon:33208"},{"id":"T1358","span":{"begin":292,"end":297},"obj":"CL_GO_EXT:cell"},{"id":"T1359","span":{"begin":360,"end":370},"obj":"GO:0010467"},{"id":"T1360","span":{"begin":419,"end":426},"obj":"CL:0002322"},{"id":"T1361","span":{"begin":422,"end":426},"obj":"CL_GO_EXT:cell"},{"id":"T1362","span":{"begin":453,"end":460},"obj":"CL:0002322"},{"id":"T1363","span":{"begin":456,"end":460},"obj":"CL_GO_EXT:cell"},{"id":"T1364","span":{"begin":495,"end":499},"obj":"UBERON:0010166"},{"id":"T1365","span":{"begin":529,"end":538},"obj":"SO_EXT:0000902"},{"id":"T1366","span":{"begin":565,"end":575},"obj":"GO:0010467"},{"id":"T1367","span":{"begin":625,"end":630},"obj":"UBERON:0000062"}],"text":"Even though our RFP transgenic ES cell lines failed to maintain strong uniform expression with in vitro passage, we selected three lines exhibiting the most robust expression for making chimeras, in order to ascertain whether we could achieve, or possibly recover, RFP expression in animals. Cells were flow sorted prior to aggregation so as to enrich for RFP expression. Even though they had lost their characteristic ES cell morphology all three RFP+ ES cell lines went gemline as detected by coat color and PCR for the DsRed1 transgene (data not shown). However expression of the RFP reporter could not be detected in any organ of adult mice nor in embryos (data not shown). This suggests that the DsRed1 RFP reporter was unable to recapitulate the expression profile of the promoter/enhancer combination employed. Therefore it appears that GFP variant reporters are more versatile with respect to their application in mice."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T1197","span":{"begin":31,"end":38},"obj":"CL:0002322"},{"id":"T1198","span":{"begin":79,"end":89},"obj":"GO:0010467"},{"id":"T1199","span":{"begin":164,"end":174},"obj":"GO:0010467"},{"id":"T1200","span":{"begin":269,"end":279},"obj":"GO:0010467"},{"id":"T1201","span":{"begin":283,"end":290},"obj":"NCBITaxon:33208"},{"id":"T1202","span":{"begin":360,"end":370},"obj":"GO:0010467"},{"id":"T1203","span":{"begin":419,"end":426},"obj":"CL:0002322"},{"id":"T1204","span":{"begin":453,"end":460},"obj":"CL:0002322"},{"id":"T1205","span":{"begin":495,"end":499},"obj":"UBERON:0010166"},{"id":"T1206","span":{"begin":529,"end":538},"obj":"SO:0000902"},{"id":"T1207","span":{"begin":565,"end":575},"obj":"GO:0010467"},{"id":"T1208","span":{"begin":625,"end":630},"obj":"UBERON:0000062"},{"id":"T1209","span":{"begin":634,"end":639},"obj":"UBERON:0007023"},{"id":"T1210","span":{"begin":640,"end":644},"obj":"NCBITaxon:10088"},{"id":"T1211","span":{"begin":652,"end":659},"obj":"UBERON:0000922"},{"id":"T1212","span":{"begin":752,"end":762},"obj":"GO:0010467"},{"id":"T1213","span":{"begin":778,"end":786},"obj":"SO:0000167"},{"id":"T1214","span":{"begin":787,"end":795},"obj":"SO:0000165"},{"id":"T1215","span":{"begin":922,"end":926},"obj":"NCBITaxon:10088"}],"text":"Even though our RFP transgenic ES cell lines failed to maintain strong uniform expression with in vitro passage, we selected three lines exhibiting the most robust expression for making chimeras, in order to ascertain whether we could achieve, or possibly recover, RFP expression in animals. Cells were flow sorted prior to aggregation so as to enrich for RFP expression. Even though they had lost their characteristic ES cell morphology all three RFP+ ES cell lines went gemline as detected by coat color and PCR for the DsRed1 transgene (data not shown). However expression of the RFP reporter could not be detected in any organ of adult mice nor in embryos (data not shown). This suggests that the DsRed1 RFP reporter was unable to recapitulate the expression profile of the promoter/enhancer combination employed. Therefore it appears that GFP variant reporters are more versatile with respect to their application in mice."}