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At each fork, one Mcm4/6/7 complex is likely to encircle the single-stranded DNA strand and two hexamers may bind symmetrically to the bubble substrate, forming a double hexameric structure on the bubble (see schematic drawing of Figure 1A). Efficient unwinding into both directions may require simultaneous activation of both hexamers which may sit at the center while extruding the unwound single-stranded DNA through the rings. This may closely resemble the proposed modes of binding and helicase actions of T-antigen (21). Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T8988","span":{"begin":38,"end":42},"obj":"PR:000010246"},{"id":"T8989","span":{"begin":38,"end":46},"obj":"GO:0097373"},{"id":"T8990","span":{"begin":71,"end":86},"obj":"SO:0000984"},{"id":"T8991","span":{"begin":192,"end":196},"obj":"GO:0005657"},{"id":"T8992","span":{"begin":202,"end":206},"obj":"PR:000010246"},{"id":"T8993","span":{"begin":202,"end":218},"obj":"GO:0097373"},{"id":"T8994","span":{"begin":245,"end":260},"obj":"SO:0000984"},{"id":"T8995","span":{"begin":576,"end":591},"obj":"SO:0000984"},{"id":"T8996","span":{"begin":697,"end":704},"obj":"CHEBI:59132"},{"id":"T8997","span":{"begin":771,"end":775},"obj":"PR:000010246"},{"id":"T8998","span":{"begin":771,"end":779},"obj":"GO:0097373"},{"id":"T8999","span":{"begin":796,"end":800},"obj":"GO:0005657"},{"id":"T9000","span":{"begin":861,"end":866},"obj":"NCBITaxon:10088"},{"id":"T9001","span":{"begin":871,"end":877},"obj":"NCBITaxon:2157"},{"id":"T9002","span":{"begin":878,"end":881},"obj":"GO:0042555"},{"id":"T9003","span":{"begin":898,"end":906},"obj":"CHEBI:10545"},{"id":"T9004","span":{"begin":980,"end":984},"obj":"NCBITaxon:10633"},{"id":"T9005","span":{"begin":993,"end":1000},"obj":"CHEBI:59132"},{"id":"T9006","span":{"begin":1062,"end":1067},"obj":"NCBITaxon:10088"},{"id":"T9007","span":{"begin":1068,"end":1071},"obj":"GO:0042555"}],"text":"Our footprinting analyses showed that Mcm4/6/7 strongly protects 25 nt single-stranded DNA segment adjacent to each branch point and proximal to 5′ ends of both strands of the bubble. At each fork, one Mcm4/6/7 complex is likely to encircle the single-stranded DNA strand and two hexamers may bind symmetrically to the bubble substrate, forming a double hexameric structure on the bubble (see schematic drawing of Figure 1A). Efficient unwinding into both directions may require simultaneous activation of both hexamers which may sit at the center while extruding the unwound single-stranded DNA through the rings. This may closely resemble the proposed modes of binding and helicase actions of T-antigen (21). Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA."}

{"project":"2_test","denotations":[{"id":"15917436-9765408-76775536","span":{"begin":706,"end":708},"obj":"9765408"},{"id":"15917436-14566326-76775537","span":{"begin":1002,"end":1003},"obj":"14566326"},{"id":"15917436-12774115-76775538","span":{"begin":1004,"end":1005},"obj":"12774115"}],"text":"Our footprinting analyses showed that Mcm4/6/7 strongly protects 25 nt single-stranded DNA segment adjacent to each branch point and proximal to 5′ ends of both strands of the bubble. At each fork, one Mcm4/6/7 complex is likely to encircle the single-stranded DNA strand and two hexamers may bind symmetrically to the bubble substrate, forming a double hexameric structure on the bubble (see schematic drawing of Figure 1A). Efficient unwinding into both directions may require simultaneous activation of both hexamers which may sit at the center while extruding the unwound single-stranded DNA through the rings. This may closely resemble the proposed modes of binding and helicase actions of T-antigen (21). Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA."}