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PMC:1140370 / 29919-31007 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T9350 0-3 PRP$ denotes Our
T9351 17-25 NNS denotes analyses
T9352 4-16 NN denotes footprinting
T9353 26-32 VBD denotes showed
T9354 33-37 IN denotes that
T9355 56-64 VBZ denotes protects
T9356 38-42 NN denotes Mcm4
T9357 42-43 HYPH denotes /
T9358 43-44 CD denotes 6
T9359 44-45 HYPH denotes /
T9360 45-46 CD denotes 7
T9361 47-55 RB denotes strongly
T9362 65-67 CD denotes 25
T9363 68-70 NN denotes nt
T9364 91-98 NN denotes segment
T9365 71-77 JJ denotes single
T9366 78-86 VBN denotes stranded
T9367 77-78 HYPH denotes -
T9368 87-90 NN denotes DNA
T9369 99-107 JJ denotes adjacent
T9370 108-110 IN denotes to
T9371 111-115 DT denotes each
T9372 123-128 NN denotes point
T9373 116-122 NN denotes branch
T9374 129-132 CC denotes and
T9375 133-141 JJ denotes proximal
T9376 142-144 IN denotes to
T9377 145-146 CD denotes 5
T9378 148-152 NNS denotes ends
T9379 146-147 SYM denotes ′
T9380 153-155 IN denotes of
T9381 156-160 DT denotes both
T9382 161-168 NNS denotes strands
T9383 169-171 IN denotes of
T9384 172-175 DT denotes the
T9385 176-182 NN denotes bubble
T9386 182-183 . denotes .
T9387 183-425 sentence denotes At each fork, one Mcm4/6/7 complex is likely to encircle the single-stranded DNA strand and two hexamers may bind symmetrically to the bubble substrate, forming a double hexameric structure on the bubble (see schematic drawing of Figure 1A).
T9388 184-186 IN denotes At
T9389 219-221 VBZ denotes is
T9390 187-191 DT denotes each
T9391 192-196 NN denotes fork
T9392 196-198 , denotes ,
T9393 198-201 CD denotes one
T9394 211-218 NN denotes complex
T9395 202-206 NN denotes Mcm4
T9396 206-207 HYPH denotes /
T9397 207-208 CD denotes 6
T9398 208-209 HYPH denotes /
T9399 209-210 CD denotes 7
T9400 222-228 JJ denotes likely
T9401 229-231 TO denotes to
T9402 232-240 VB denotes encircle
T9403 241-244 DT denotes the
T9404 265-271 NN denotes strand
T9405 245-251 JJ denotes single
T9406 252-260 VBN denotes stranded
T9407 251-252 HYPH denotes -
T9408 261-264 NN denotes DNA
T9409 272-275 CC denotes and
T9410 276-279 CD denotes two
T9411 280-288 NNS denotes hexamers
T9412 293-297 VB denotes bind
T9413 289-292 MD denotes may
T9414 298-311 RB denotes symmetrically
T9415 312-314 IN denotes to
T9416 315-318 DT denotes the
T9417 326-335 NN denotes substrate
T9418 319-325 NN denotes bubble
T9419 335-337 , denotes ,
T9420 337-344 VBG denotes forming
T9421 345-346 DT denotes a
T9422 364-373 NN denotes structure
T9423 347-353 JJ denotes double
T9424 354-363 JJ denotes hexameric
T9425 374-376 IN denotes on
T9426 377-380 DT denotes the
T9427 381-387 NN denotes bubble
T9428 388-389 -LRB- denotes (
T9429 389-392 VB denotes see
T9430 393-402 JJ denotes schematic
T9431 403-410 NN denotes drawing
T9432 411-413 IN denotes of
T9433 414-420 NN denotes Figure
T9434 421-423 NN denotes 1A
T9435 423-424 -RRB- denotes )
T9436 424-425 . denotes .
T9437 425-614 sentence denotes Efficient unwinding into both directions may require simultaneous activation of both hexamers which may sit at the center while extruding the unwound single-stranded DNA through the rings.
T9438 426-435 JJ denotes Efficient
T9439 436-445 NN denotes unwinding
T9440 471-478 VB denotes require
T9441 446-450 IN denotes into
T9442 451-455 DT denotes both
T9443 456-466 NNS denotes directions
T9444 467-470 MD denotes may
T9445 479-491 JJ denotes simultaneous
T9446 492-502 NN denotes activation
T9447 503-505 IN denotes of
T9448 506-510 DT denotes both
T9449 511-519 NNS denotes hexamers
T9450 520-525 WDT denotes which
T9451 530-533 VB denotes sit
T9452 526-529 MD denotes may
T9453 534-536 IN denotes at
T9454 537-540 DT denotes the
T9455 541-547 NN denotes center
T9456 548-553 IN denotes while
T9457 554-563 VBG denotes extruding
T9458 564-567 DT denotes the
T9459 592-595 NN denotes DNA
T9460 568-575 JJ denotes unwound
T9461 576-582 JJ denotes single
T9462 583-591 VBN denotes stranded
T9463 582-583 HYPH denotes -
T9464 596-603 IN denotes through
T9465 604-607 DT denotes the
T9466 608-613 NNS denotes rings
T9467 613-614 . denotes .
T9468 614-710 sentence denotes This may closely resemble the proposed modes of binding and helicase actions of T-antigen (21).
T9469 615-619 DT denotes This
T9470 632-640 VB denotes resemble
T9471 620-623 MD denotes may
T9472 624-631 RB denotes closely
T9473 641-644 DT denotes the
T9474 654-659 NNS denotes modes
T9475 645-653 VBN denotes proposed
T9476 660-662 IN denotes of
T9477 663-670 NN denotes binding
T9478 684-691 NNS denotes actions
T9479 671-674 CC denotes and
T9480 675-683 NN denotes helicase
T9481 692-694 IN denotes of
T9482 695-696 NN denotes T
T9483 697-704 NN denotes antigen
T9484 696-697 HYPH denotes -
T9485 705-706 -LRB- denotes (
T9486 706-708 CD denotes 21
T9487 708-709 -RRB- denotes )
T9488 709-710 . denotes .
T9489 710-1088 sentence denotes Although we cannot totally exclude the possibility that one Mcm4/6/7 hexamer at each fork unwinds the duplex independently, ring-shaped structures of mouse and archea MCM, as revealed by electron microscopy, bear much similarity to the recently solved structure of the SV40 large T-antigen (4,6), and are in favor of the double-hexameric structure of mouse Mcm on a bubble DNA.
T9490 711-719 IN denotes Although
T9491 738-745 VB denotes exclude
T9492 720-722 PRP denotes we
T9493 723-726 MD denotes can
T9494 726-729 RB denotes not
T9495 730-737 RB denotes totally
T9496 919-923 VBP denotes bear
T9497 746-749 DT denotes the
T9498 750-761 NN denotes possibility
T9499 762-766 IN denotes that
T9500 801-808 VBZ denotes unwinds
T9501 767-770 CD denotes one
T9502 780-787 NN denotes hexamer
T9503 771-775 NN denotes Mcm4
T9504 775-776 HYPH denotes /
T9505 776-777 CD denotes 6
T9506 777-778 HYPH denotes /
T9507 778-779 CD denotes 7
T9508 788-790 IN denotes at
T9509 791-795 DT denotes each
T9510 796-800 NN denotes fork
T9511 809-812 DT denotes the
T9512 813-819 NN denotes duplex
T9513 820-833 RB denotes independently
T9514 833-835 , denotes ,
T9515 835-839 NN denotes ring
T9516 840-846 VBN denotes shaped
T9517 839-840 HYPH denotes -
T9518 847-857 NNS denotes structures
T9519 858-860 IN denotes of
T9520 861-866 NN denotes mouse
T9521 878-881 NN denotes MCM
T9522 867-870 CC denotes and
T9523 871-877 NN denotes archea
T9524 881-883 , denotes ,
T9525 883-885 IN denotes as
T9526 886-894 VBN denotes revealed
T9527 895-897 IN denotes by
T9528 898-906 NN denotes electron
T9529 907-917 NN denotes microscopy
T9530 917-919 , denotes ,
T9531 924-928 JJ denotes much
T9532 929-939 NN denotes similarity
T9533 940-942 IN denotes to
T9534 943-946 DT denotes the
T9535 963-972 NN denotes structure
T9536 947-955 RB denotes recently
T9537 956-962 VBN denotes solved
T9538 973-975 IN denotes of
T9539 976-979 DT denotes the
T9540 993-1000 NN denotes antigen
T9541 980-984 NN denotes SV40
T9542 985-990 JJ denotes large
T9543 991-992 NN denotes T
T9544 992-993 HYPH denotes -
T9545 1001-1002 -LRB- denotes (
T9546 1004-1005 CD denotes 6
T9547 1002-1003 CD denotes 4
T9548 1003-1004 , denotes ,
T9549 1005-1006 -RRB- denotes )
T9550 1006-1008 , denotes ,
T9551 1008-1011 CC denotes and
T9552 1012-1015 VBP denotes are
T9553 1016-1018 IN denotes in
T9554 1019-1024 NN denotes favor
T9555 1025-1027 IN denotes of
T9556 1028-1031 DT denotes the
T9557 1049-1058 NN denotes structure
T9558 1032-1038 JJ denotes double
T9559 1039-1048 JJ denotes hexameric
T9560 1038-1039 HYPH denotes -
T9561 1059-1061 IN denotes of
T9562 1062-1067 NN denotes mouse
T9563 1068-1071 NN denotes Mcm
T9564 1072-1074 IN denotes on
T9565 1075-1076 DT denotes a
T9566 1084-1087 NN denotes DNA
T9567 1077-1083 NN denotes bubble
T9568 1087-1088 . denotes .
R6243 T9350 T9351 poss Our,analyses
R6244 T9351 T9353 nsubj analyses,showed
R6245 T9352 T9351 compound footprinting,analyses
R6246 T9354 T9355 mark that,protects
R6247 T9355 T9353 ccomp protects,showed
R6248 T9356 T9355 nsubj Mcm4,protects
R6249 T9357 T9356 punct /,Mcm4
R6250 T9358 T9356 nummod 6,Mcm4
R6251 T9359 T9356 punct /,Mcm4
R6252 T9360 T9356 nummod 7,Mcm4
R6253 T9361 T9355 advmod strongly,protects
R6254 T9362 T9363 nummod 25,nt
R6255 T9363 T9364 nmod nt,segment
R6256 T9364 T9355 dobj segment,protects
R6257 T9365 T9366 amod single,stranded
R6258 T9366 T9364 amod stranded,segment
R6259 T9367 T9366 punct -,stranded
R6260 T9368 T9364 compound DNA,segment
R6261 T9369 T9364 amod adjacent,segment
R6262 T9370 T9369 prep to,adjacent
R6263 T9371 T9372 det each,point
R6264 T9372 T9370 pobj point,to
R6265 T9373 T9372 compound branch,point
R6266 T9374 T9369 cc and,adjacent
R6267 T9375 T9369 conj proximal,adjacent
R6268 T9376 T9375 prep to,proximal
R6269 T9377 T9378 nummod 5,ends
R6270 T9378 T9376 pobj ends,to
R6271 T9379 T9377 punct ′,5
R6272 T9380 T9378 prep of,ends
R6273 T9381 T9382 det both,strands
R6274 T9382 T9380 pobj strands,of
R6275 T9383 T9382 prep of,strands
R6276 T9384 T9385 det the,bubble
R6277 T9385 T9383 pobj bubble,of
R6278 T9386 T9353 punct .,showed
R6279 T9388 T9389 prep At,is
R6280 T9390 T9391 det each,fork
R6281 T9391 T9388 pobj fork,At
R6282 T9392 T9389 punct ", ",is
R6283 T9393 T9394 nummod one,complex
R6284 T9394 T9389 nsubj complex,is
R6285 T9395 T9394 nmod Mcm4,complex
R6286 T9396 T9395 punct /,Mcm4
R6287 T9397 T9395 nummod 6,Mcm4
R6288 T9398 T9395 punct /,Mcm4
R6289 T9399 T9395 nummod 7,Mcm4
R6290 T9400 T9389 acomp likely,is
R6291 T9401 T9402 aux to,encircle
R6292 T9402 T9400 xcomp encircle,likely
R6293 T9403 T9404 det the,strand
R6294 T9404 T9402 dobj strand,encircle
R6295 T9405 T9406 amod single,stranded
R6296 T9406 T9404 amod stranded,strand
R6297 T9407 T9406 punct -,stranded
R6298 T9408 T9404 compound DNA,strand
R6299 T9409 T9389 cc and,is
R6300 T9410 T9411 nummod two,hexamers
R6301 T9411 T9412 nsubj hexamers,bind
R6302 T9412 T9389 conj bind,is
R6303 T9413 T9412 aux may,bind
R6304 T9414 T9412 advmod symmetrically,bind
R6305 T9415 T9412 prep to,bind
R6306 T9416 T9417 det the,substrate
R6307 T9417 T9415 pobj substrate,to
R6308 T9418 T9417 compound bubble,substrate
R6309 T9419 T9412 punct ", ",bind
R6310 T9420 T9412 advcl forming,bind
R6311 T9421 T9422 det a,structure
R6312 T9422 T9420 dobj structure,forming
R6313 T9423 T9424 amod double,hexameric
R6314 T9424 T9422 amod hexameric,structure
R6315 T9425 T9420 prep on,forming
R6316 T9426 T9427 det the,bubble
R6317 T9427 T9425 pobj bubble,on
R6318 T9428 T9429 punct (,see
R6319 T9429 T9420 parataxis see,forming
R6320 T9430 T9431 amod schematic,drawing
R6321 T9431 T9429 dobj drawing,see
R6322 T9432 T9431 prep of,drawing
R6323 T9433 T9434 compound Figure,1A
R6324 T9434 T9432 pobj 1A,of
R6325 T9435 T9429 punct ),see
R6326 T9436 T9412 punct .,bind
R6327 T9438 T9439 amod Efficient,unwinding
R6328 T9439 T9440 nsubj unwinding,require
R6329 T9441 T9439 prep into,unwinding
R6330 T9442 T9443 det both,directions
R6331 T9443 T9441 pobj directions,into
R6332 T9444 T9440 aux may,require
R6333 T9445 T9446 amod simultaneous,activation
R6334 T9446 T9440 dobj activation,require
R6335 T9447 T9446 prep of,activation
R6336 T9448 T9449 det both,hexamers
R6337 T9449 T9447 pobj hexamers,of
R6338 T9450 T9451 dep which,sit
R6339 T9451 T9449 relcl sit,hexamers
R6340 T9452 T9451 aux may,sit
R6341 T9453 T9451 prep at,sit
R6342 T9454 T9455 det the,center
R6343 T9455 T9453 pobj center,at
R6344 T9456 T9457 mark while,extruding
R6345 T9457 T9451 advcl extruding,sit
R6346 T9458 T9459 det the,DNA
R6347 T9459 T9457 dobj DNA,extruding
R6348 T9460 T9459 amod unwound,DNA
R6349 T9461 T9462 amod single,stranded
R6350 T9462 T9459 amod stranded,DNA
R6351 T9463 T9462 punct -,stranded
R6352 T9464 T9457 prep through,extruding
R6353 T9465 T9466 det the,rings
R6354 T9466 T9464 pobj rings,through
R6355 T9467 T9440 punct .,require
R6356 T9469 T9470 nsubj This,resemble
R6357 T9471 T9470 aux may,resemble
R6358 T9472 T9470 advmod closely,resemble
R6359 T9473 T9474 det the,modes
R6360 T9474 T9470 dobj modes,resemble
R6361 T9475 T9474 amod proposed,modes
R6362 T9476 T9474 prep of,modes
R6363 T9477 T9478 nmod binding,actions
R6364 T9478 T9476 pobj actions,of
R6365 T9479 T9477 cc and,binding
R6366 T9480 T9477 conj helicase,binding
R6367 T9481 T9478 prep of,actions
R6368 T9482 T9483 compound T,antigen
R6369 T9483 T9481 pobj antigen,of
R6370 T9484 T9483 punct -,antigen
R6371 T9485 T9486 punct (,21
R6372 T9486 T9470 parataxis 21,resemble
R6373 T9487 T9486 punct ),21
R6374 T9488 T9470 punct .,resemble
R6375 T9490 T9491 mark Although,exclude
R6376 T9491 T9496 advcl exclude,bear
R6377 T9492 T9491 nsubj we,exclude
R6378 T9493 T9491 aux can,exclude
R6379 T9494 T9491 neg not,exclude
R6380 T9495 T9491 advmod totally,exclude
R6381 T9497 T9498 det the,possibility
R6382 T9498 T9491 dobj possibility,exclude
R6383 T9499 T9500 mark that,unwinds
R6384 T9500 T9498 acl unwinds,possibility
R6385 T9501 T9502 nummod one,hexamer
R6386 T9502 T9500 nsubj hexamer,unwinds
R6387 T9503 T9502 nmod Mcm4,hexamer
R6388 T9504 T9503 punct /,Mcm4
R6389 T9505 T9503 nummod 6,Mcm4
R6390 T9506 T9503 punct /,Mcm4
R6391 T9507 T9503 nummod 7,Mcm4
R6392 T9508 T9502 prep at,hexamer
R6393 T9509 T9510 det each,fork
R6394 T9510 T9508 pobj fork,at
R6395 T9511 T9512 det the,duplex
R6396 T9512 T9500 dobj duplex,unwinds
R6397 T9513 T9500 advmod independently,unwinds
R6398 T9514 T9496 punct ", ",bear
R6399 T9515 T9516 npadvmod ring,shaped
R6400 T9516 T9518 amod shaped,structures
R6401 T9517 T9516 punct -,shaped
R6402 T9518 T9496 nsubj structures,bear
R6403 T9519 T9518 prep of,structures
R6404 T9520 T9521 nmod mouse,MCM
R6405 T9521 T9519 pobj MCM,of
R6406 T9522 T9520 cc and,mouse
R6407 T9523 T9520 conj archea,mouse
R6408 T9524 T9496 punct ", ",bear
R6409 T9525 T9526 mark as,revealed
R6410 T9526 T9496 advcl revealed,bear
R6411 T9527 T9526 agent by,revealed
R6412 T9528 T9529 compound electron,microscopy
R6413 T9529 T9527 pobj microscopy,by
R6414 T9530 T9496 punct ", ",bear
R6415 T9531 T9532 amod much,similarity
R6416 T9532 T9496 dobj similarity,bear
R6417 T9533 T9532 prep to,similarity
R6418 T9534 T9535 det the,structure
R6419 T9535 T9533 pobj structure,to
R6420 T9536 T9537 advmod recently,solved
R6421 T9537 T9535 amod solved,structure
R6422 T9538 T9535 prep of,structure
R6423 T9539 T9540 det the,antigen
R6424 T9540 T9538 pobj antigen,of
R6425 T9541 T9540 nmod SV40,antigen
R6426 T9542 T9540 amod large,antigen
R6427 T9543 T9540 compound T,antigen
R6428 T9544 T9540 punct -,antigen
R6429 T9545 T9546 punct (,6
R6430 T9546 T9535 parataxis 6,structure
R6431 T9547 T9546 nummod 4,6
R6432 T9548 T9546 punct ",",6
R6433 T9549 T9546 punct ),6
R6434 T9550 T9496 punct ", ",bear
R6435 T9551 T9496 cc and,bear
R6436 T9552 T9496 conj are,bear
R6437 T9553 T9552 prep in,are
R6438 T9554 T9553 pobj favor,in
R6439 T9555 T9554 prep of,favor
R6440 T9556 T9557 det the,structure
R6441 T9557 T9555 pobj structure,of
R6442 T9558 T9559 amod double,hexameric
R6443 T9559 T9557 amod hexameric,structure
R6444 T9560 T9559 punct -,hexameric
R6445 T9561 T9557 prep of,structure
R6446 T9562 T9563 compound mouse,Mcm
R6447 T9563 T9561 pobj Mcm,of
R6448 T9564 T9557 prep on,structure
R6449 T9565 T9566 det a,DNA
R6450 T9566 T9564 pobj DNA,on
R6451 T9567 T9566 compound bubble,DNA
R6452 T9568 T9496 punct .,bear

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9058 38-42 PR_EXT:000010246 denotes Mcm4
T9059 38-46 GO:0097373 denotes Mcm4/6/7
T9060 68-70 CHEBI_SO_EXT:nucleotide denotes nt
T9061 71-90 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9062 192-196 GO:0005657 denotes fork
T9063 202-206 PR_EXT:000010246 denotes Mcm4
T9064 202-218 GO:0097373 denotes Mcm4/6/7 complex
T9065 245-264 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9066 280-288 GO_EXT:hexameric_macromolecular_complex denotes hexamers
T9067 293-297 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T9068 347-363 GO_EXT:double_hexameric_macromolecular_complex denotes double hexameric
T9069 511-519 GO_EXT:hexameric_macromolecular_complex denotes hexamers
T9070 576-595 CHEBI_SO_EXT:single_stranded_DNA denotes single-stranded DNA
T9071 663-670 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T9072 675-683 GO_EXT:0004386 denotes helicase
T9073 697-704 CHEBI_EXT:59132 denotes antigen
T9074 771-775 PR_EXT:000010246 denotes Mcm4
T9075 771-779 GO:0097373 denotes Mcm4/6/7
T9076 780-787 GO_EXT:hexameric_macromolecular_complex denotes hexamer
T9077 796-800 GO:0005657 denotes fork
T9078 861-866 NCBITaxon:10088 denotes mouse
T9079 871-877 NCBITaxon:2157 denotes archea
T9080 878-881 GO:0042555 denotes MCM
T9081 898-906 CHEBI:10545 denotes electron
T9082 980-984 NCBITaxon:10633 denotes SV40
T9083 993-1000 CHEBI_EXT:59132 denotes antigen
T9084 1032-1048 GO_EXT:double_hexameric_macromolecular_complex denotes double-hexameric
T9085 1062-1067 NCBITaxon:10088 denotes mouse
T9086 1068-1071 GO:0042555 denotes Mcm
T9087 1084-1087 CHEBI_SO_EXT:DNA denotes DNA

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T8988 38-42 PR:000010246 denotes Mcm4
T8989 38-46 GO:0097373 denotes Mcm4/6/7
T8990 71-86 SO:0000984 denotes single-stranded
T8991 192-196 GO:0005657 denotes fork
T8992 202-206 PR:000010246 denotes Mcm4
T8993 202-218 GO:0097373 denotes Mcm4/6/7 complex
T8994 245-260 SO:0000984 denotes single-stranded
T8995 576-591 SO:0000984 denotes single-stranded
T8996 697-704 CHEBI:59132 denotes antigen
T8997 771-775 PR:000010246 denotes Mcm4
T8998 771-779 GO:0097373 denotes Mcm4/6/7
T8999 796-800 GO:0005657 denotes fork
T9000 861-866 NCBITaxon:10088 denotes mouse
T9001 871-877 NCBITaxon:2157 denotes archea
T9002 878-881 GO:0042555 denotes MCM
T9003 898-906 CHEBI:10545 denotes electron
T9004 980-984 NCBITaxon:10633 denotes SV40
T9005 993-1000 CHEBI:59132 denotes antigen
T9006 1062-1067 NCBITaxon:10088 denotes mouse
T9007 1068-1071 GO:0042555 denotes Mcm

2_test

Id Subject Object Predicate Lexical cue
15917436-9765408-76775536 706-708 9765408 denotes 21
15917436-14566326-76775537 1002-1003 14566326 denotes 4
15917436-12774115-76775538 1004-1005 12774115 denotes 6