PMC:1140370 / 2486-2755 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1140370","sourcedb":"PMC","sourceid":"1140370","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1140370","text":" While Mcm4, Mcm6 and Mcm7 proteins make distinct contribution to its helicase activity (11–13), Mcm2 or Mcm3/5 inhibit the helicase activity of the Mcm4/6/7 complex by converting its double trimer structure into a heterotetramer or heteropentamer, respectively (3,11).","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T968","span":{"begin":0,"end":269},"obj":"sentence"},{"id":"T969","span":{"begin":1,"end":6},"obj":"IN"},{"id":"T970","span":{"begin":36,"end":40},"obj":"VBP"},{"id":"T971","span":{"begin":7,"end":11},"obj":"NN"},{"id":"T972","span":{"begin":27,"end":35},"obj":"NN"},{"id":"T973","span":{"begin":11,"end":13},"obj":","},{"id":"T974","span":{"begin":13,"end":17},"obj":"NN"},{"id":"T975","span":{"begin":18,"end":21},"obj":"CC"},{"id":"T976","span":{"begin":22,"end":26},"obj":"NN"},{"id":"T977","span":{"begin":112,"end":119},"obj":"VBP"},{"id":"T978","span":{"begin":41,"end":49},"obj":"JJ"},{"id":"T979","span":{"begin":50,"end":62},"obj":"NN"},{"id":"T980","span":{"begin":63,"end":65},"obj":"IN"},{"id":"T981","span":{"begin":66,"end":69},"obj":"PRP$"},{"id":"T982","span":{"begin":79,"end":87},"obj":"NN"},{"id":"T983","span":{"begin":70,"end":78},"obj":"NN"},{"id":"T984","span":{"begin":88,"end":89},"obj":"-LRB-"},{"id":"T985","span":{"begin":89,"end":91},"obj":"CD"},{"id":"T986","span":{"begin":91,"end":92},"obj":"SYM"},{"id":"T987","span":{"begin":92,"end":94},"obj":"CD"},{"id":"T988","span":{"begin":94,"end":95},"obj":"-RRB-"},{"id":"T989","span":{"begin":95,"end":97},"obj":","},{"id":"T990","span":{"begin":97,"end":101},"obj":"NN"},{"id":"T991","span":{"begin":102,"end":104},"obj":"CC"},{"id":"T992","span":{"begin":105,"end":109},"obj":"NN"},{"id":"T993","span":{"begin":109,"end":110},"obj":"HYPH"},{"id":"T994","span":{"begin":110,"end":111},"obj":"CD"},{"id":"T995","span":{"begin":120,"end":123},"obj":"DT"},{"id":"T996","span":{"begin":133,"end":141},"obj":"NN"},{"id":"T997","span":{"begin":124,"end":132},"obj":"NN"},{"id":"T998","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T999","span":{"begin":145,"end":148},"obj":"DT"},{"id":"T1000","span":{"begin":158,"end":165},"obj":"NN"},{"id":"T1001","span":{"begin":149,"end":153},"obj":"NN"},{"id":"T1002","span":{"begin":153,"end":154},"obj":"HYPH"},{"id":"T1003","span":{"begin":154,"end":155},"obj":"CD"},{"id":"T1004","span":{"begin":155,"end":156},"obj":"HYPH"},{"id":"T1005","span":{"begin":156,"end":157},"obj":"CD"},{"id":"T1006","span":{"begin":166,"end":168},"obj":"IN"},{"id":"T1007","span":{"begin":169,"end":179},"obj":"VBG"},{"id":"T1008","span":{"begin":180,"end":183},"obj":"PRP$"},{"id":"T1009","span":{"begin":198,"end":207},"obj":"NN"},{"id":"T1010","span":{"begin":184,"end":190},"obj":"JJ"},{"id":"T1011","span":{"begin":191,"end":197},"obj":"NN"},{"id":"T1012","span":{"begin":208,"end":212},"obj":"IN"},{"id":"T1013","span":{"begin":213,"end":214},"obj":"DT"},{"id":"T1014","span":{"begin":215,"end":229},"obj":"NN"},{"id":"T1015","span":{"begin":230,"end":232},"obj":"CC"},{"id":"T1016","span":{"begin":233,"end":247},"obj":"NN"},{"id":"T1017","span":{"begin":247,"end":249},"obj":","},{"id":"T1018","span":{"begin":249,"end":261},"obj":"RB"},{"id":"T1019","span":{"begin":262,"end":263},"obj":"-LRB-"},{"id":"T1020","span":{"begin":265,"end":267},"obj":"CD"},{"id":"T1021","span":{"begin":263,"end":264},"obj":"CD"},{"id":"T1022","span":{"begin":264,"end":265},"obj":","},{"id":"T1023","span":{"begin":267,"end":268},"obj":"-RRB-"},{"id":"T1024","span":{"begin":268,"end":269},"obj":"."}],"relations":[{"id":"R478","pred":"mark","subj":"T969","obj":"T970"},{"id":"R480","pred":"nmod","subj":"T971","obj":"T972"},{"id":"R481","pred":"nsubj","subj":"T972","obj":"T970"},{"id":"R482","pred":"punct","subj":"T973","obj":"T971"},{"id":"R483","pred":"conj","subj":"T974","obj":"T971"},{"id":"R484","pred":"cc","subj":"T975","obj":"T974"},{"id":"R485","pred":"conj","subj":"T976","obj":"T974"},{"id":"R486","pred":"amod","subj":"T978","obj":"T979"},{"id":"R487","pred":"dobj","subj":"T979","obj":"T970"},{"id":"R488","pred":"prep","subj":"T980","obj":"T979"},{"id":"R489","pred":"poss","subj":"T981","obj":"T982"},{"id":"R490","pred":"pobj","subj":"T982","obj":"T980"},{"id":"R491","pred":"compound","subj":"T983","obj":"T982"},{"id":"R492","pred":"punct","subj":"T984","obj":"T985"},{"id":"R493","pred":"parataxis","subj":"T985","obj":"T970"},{"id":"R494","pred":"punct","subj":"T986","obj":"T987"},{"id":"R495","pred":"prep","subj":"T987","obj":"T985"},{"id":"R496","pred":"punct","subj":"T988","obj":"T985"},{"id":"R497","pred":"punct","subj":"T989","obj":"T977"},{"id":"R498","pred":"nsubj","subj":"T990","obj":"T977"},{"id":"R499","pred":"cc","subj":"T991","obj":"T990"},{"id":"R500","pred":"conj","subj":"T992","obj":"T990"},{"id":"R501","pred":"punct","subj":"T993","obj":"T992"},{"id":"R502","pred":"nummod","subj":"T994","obj":"T992"},{"id":"R503","pred":"det","subj":"T995","obj":"T996"},{"id":"R504","pred":"dobj","subj":"T996","obj":"T977"},{"id":"R505","pred":"compound","subj":"T997","obj":"T996"},{"id":"R506","pred":"prep","subj":"T998","obj":"T996"},{"id":"R507","pred":"det","subj":"T999","obj":"T1000"},{"id":"R508","pred":"pobj","subj":"T1000","obj":"T998"},{"id":"R509","pred":"nmod","subj":"T1001","obj":"T1000"},{"id":"R510","pred":"punct","subj":"T1002","obj":"T1001"},{"id":"R511","pred":"nummod","subj":"T1003","obj":"T1001"},{"id":"R512","pred":"punct","subj":"T1004","obj":"T1001"},{"id":"R513","pred":"nummod","subj":"T1005","obj":"T1001"},{"id":"R514","pred":"prep","subj":"T1006","obj":"T977"},{"id":"R515","pred":"pcomp","subj":"T1007","obj":"T1006"},{"id":"R516","pred":"poss","subj":"T1008","obj":"T1009"},{"id":"R517","pred":"dobj","subj":"T1009","obj":"T1007"},{"id":"R518","pred":"amod","subj":"T1010","obj":"T1009"},{"id":"R519","pred":"compound","subj":"T1011","obj":"T1009"},{"id":"R520","pred":"prep","subj":"T1012","obj":"T1007"},{"id":"R521","pred":"det","subj":"T1013","obj":"T1014"},{"id":"R522","pred":"pobj","subj":"T1014","obj":"T1012"},{"id":"R523","pred":"cc","subj":"T1015","obj":"T1014"},{"id":"R524","pred":"conj","subj":"T1016","obj":"T1014"},{"id":"R525","pred":"punct","subj":"T1017","obj":"T1007"},{"id":"R526","pred":"advmod","subj":"T1018","obj":"T1007"},{"id":"R527","pred":"punct","subj":"T1019","obj":"T1020"},{"id":"R528","pred":"parataxis","subj":"T1020","obj":"T1007"},{"id":"R529","pred":"nummod","subj":"T1021","obj":"T1020"},{"id":"R530","pred":"punct","subj":"T1022","obj":"T1020"},{"id":"R531","pred":"punct","subj":"T1023","obj":"T1020"},{"id":"R532","pred":"punct","subj":"T1024","obj":"T977"},{"id":"R479","pred":"advcl","subj":"T970","obj":"T977"}],"attributes":[{"subj":"T968","pred":"source","obj":"craft-sa-dev"},{"subj":"T969","pred":"source","obj":"craft-sa-dev"},{"subj":"T970","pred":"source","obj":"craft-sa-dev"},{"subj":"T971","pred":"source","obj":"craft-sa-dev"},{"subj":"T972","pred":"source","obj":"craft-sa-dev"},{"subj":"T973","pred":"source","obj":"craft-sa-dev"},{"subj":"T974","pred":"source","obj":"craft-sa-dev"},{"subj":"T975","pred":"source","obj":"craft-sa-dev"},{"subj":"T976","pred":"source","obj":"craft-sa-dev"},{"subj":"T977","pred":"source","obj":"craft-sa-dev"},{"subj":"T978","pred":"source","obj":"craft-sa-dev"},{"subj":"T979","pred":"source","obj":"craft-sa-dev"},{"subj":"T980","pred":"source","obj":"craft-sa-dev"},{"subj":"T981","pred":"source","obj":"craft-sa-dev"},{"subj":"T982","pred":"source","obj":"craft-sa-dev"},{"subj":"T983","pred":"source","obj":"craft-sa-dev"},{"subj":"T984","pred":"source","obj":"craft-sa-dev"},{"subj":"T985","pred":"source","obj":"craft-sa-dev"},{"subj":"T986","pred":"source","obj":"craft-sa-dev"},{"subj":"T987","pred":"source","obj":"craft-sa-dev"},{"subj":"T988","pred":"source","obj":"craft-sa-dev"},{"subj":"T989","pred":"source","obj":"craft-sa-dev"},{"subj":"T990","pred":"source","obj":"craft-sa-dev"},{"subj":"T991","pred":"source","obj":"craft-sa-dev"},{"subj":"T992","pred":"source","obj":"craft-sa-dev"},{"subj":"T993","pred":"source","obj":"craft-sa-dev"},{"subj":"T994","pred":"source","obj":"craft-sa-dev"},{"subj":"T995","pred":"source","obj":"craft-sa-dev"},{"subj":"T996","pred":"source","obj":"craft-sa-dev"},{"subj":"T997","pred":"source","obj":"craft-sa-dev"},{"subj":"T998","pred":"source","obj":"craft-sa-dev"},{"subj":"T999","pred":"source","obj":"craft-sa-dev"},{"subj":"T1000","pred":"source","obj":"craft-sa-dev"},{"subj":"T1001","pred":"source","obj":"craft-sa-dev"},{"subj":"T1002","pred":"source","obj":"craft-sa-dev"},{"subj":"T1003","pred":"source","obj":"craft-sa-dev"},{"subj":"T1004","pred":"source","obj":"craft-sa-dev"},{"subj":"T1005","pred":"source","obj":"craft-sa-dev"},{"subj":"T1006","pred":"source","obj":"craft-sa-dev"},{"subj":"T1007","pred":"source","obj":"craft-sa-dev"},{"subj":"T1008","pred":"source","obj":"craft-sa-dev"},{"subj":"T1009","pred":"source","obj":"craft-sa-dev"},{"subj":"T1010","pred":"source","obj":"craft-sa-dev"},{"subj":"T1011","pred":"source","obj":"craft-sa-dev"},{"subj":"T1012","pred":"source","obj":"craft-sa-dev"},{"subj":"T1013","pred":"source","obj":"craft-sa-dev"},{"subj":"T1014","pred":"source","obj":"craft-sa-dev"},{"subj":"T1015","pred":"source","obj":"craft-sa-dev"},{"subj":"T1016","pred":"source","obj":"craft-sa-dev"},{"subj":"T1017","pred":"source","obj":"craft-sa-dev"},{"subj":"T1018","pred":"source","obj":"craft-sa-dev"},{"subj":"T1019","pred":"source","obj":"craft-sa-dev"},{"subj":"T1020","pred":"source","obj":"craft-sa-dev"},{"subj":"T1021","pred":"source","obj":"craft-sa-dev"},{"subj":"T1022","pred":"source","obj":"craft-sa-dev"},{"subj":"T1023","pred":"source","obj":"craft-sa-dev"},{"subj":"T1024","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T673","span":{"begin":7,"end":11},"obj":"PR_EXT:000010246"},{"id":"T674","span":{"begin":13,"end":17},"obj":"PR_EXT:000010248"},{"id":"T675","span":{"begin":22,"end":26},"obj":"PR_EXT:000010249"},{"id":"T676","span":{"begin":27,"end":35},"obj":"CHEBI_PR_EXT:protein"},{"id":"T677","span":{"begin":70,"end":78},"obj":"GO_EXT:0004386"},{"id":"T678","span":{"begin":97,"end":101},"obj":"PR_EXT:000010242"},{"id":"T679","span":{"begin":105,"end":109},"obj":"PR_EXT:000010243"},{"id":"T680","span":{"begin":124,"end":132},"obj":"GO_EXT:0004386"},{"id":"T681","span":{"begin":149,"end":153},"obj":"PR_EXT:000010246"},{"id":"T682","span":{"begin":149,"end":165},"obj":"GO:0097373"},{"id":"T683","span":{"begin":184,"end":197},"obj":"GO_EXT:double_trimer_macromolecular_complex"},{"id":"T684","span":{"begin":221,"end":229},"obj":"GO_EXT:tetrameric_macromolecular_complex"},{"id":"T685","span":{"begin":239,"end":247},"obj":"GO_EXT:pentameric_macromolecular_complex"}],"attributes":[{"subj":"T673","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T674","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T675","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T676","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T677","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T678","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T679","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T680","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T681","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T682","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T683","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T684","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T685","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T571","span":{"begin":7,"end":11},"obj":"PR:000010246"},{"id":"T572","span":{"begin":13,"end":17},"obj":"PR:000010248"},{"id":"T573","span":{"begin":22,"end":26},"obj":"PR:000010249"},{"id":"T574","span":{"begin":97,"end":101},"obj":"PR:000010242"},{"id":"T575","span":{"begin":105,"end":109},"obj":"PR:000010243"},{"id":"T576","span":{"begin":149,"end":153},"obj":"PR:000010246"},{"id":"T577","span":{"begin":149,"end":165},"obj":"GO:0097373"}],"attributes":[{"subj":"T571","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T572","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T573","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T574","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T575","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T576","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T577","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"2_test","denotations":[{"id":"15917436-10567526-76775490","span":{"begin":89,"end":91},"obj":"10567526"},{"id":"15917436-12207017-76775490","span":{"begin":89,"end":91},"obj":"12207017"},{"id":"15917436-14609960-76775490","span":{"begin":89,"end":91},"obj":"14609960"},{"id":"15917436-10884341-76775491","span":{"begin":263,"end":264},"obj":"10884341"},{"id":"15917436-10567526-76775492","span":{"begin":265,"end":267},"obj":"10567526"}],"attributes":[{"subj":"15917436-10567526-76775490","pred":"source","obj":"2_test"},{"subj":"15917436-12207017-76775490","pred":"source","obj":"2_test"},{"subj":"15917436-14609960-76775490","pred":"source","obj":"2_test"},{"subj":"15917436-10884341-76775491","pred":"source","obj":"2_test"},{"subj":"15917436-10567526-76775492","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ec93df","default":true},{"id":"craft-ca-core-ex-dev","color":"#93ecde"},{"id":"craft-ca-core-dev","color":"#ecc493"},{"id":"2_test","color":"#aa93ec"}]}]}}