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In order to examine other natural replication origins with different thymine contents for the ability to activate Mcm helicase on a bubble substrate, we constructed new bubble substrates, Bub82/c-myc, containing sequences derived from the DUE (DNA unwinding element) region of the human c-myc origin which is essential for c-myc replicator activity (29,30)."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T6905","span":{"begin":35,"end":46},"obj":"GO:0006260"},{"id":"T6906","span":{"begin":35,"end":54},"obj":"SO:0000296"},{"id":"T6907","span":{"begin":115,"end":118},"obj":"GO:0042555"},{"id":"T6908","span":{"begin":195,"end":200},"obj":"PR:000000084"},{"id":"T6909","span":{"begin":245,"end":258},"obj":"GO:0032508"},{"id":"T6910","span":{"begin":282,"end":287},"obj":"NCBITaxon:9606"},{"id":"T6911","span":{"begin":288,"end":293},"obj":"PR:000000084"},{"id":"T6912","span":{"begin":294,"end":300},"obj":"SO:0000296"},{"id":"T6913","span":{"begin":324,"end":329},"obj":"PR:000000084"}],"text":" In order to examine other natural replication origins with different thymine contents for the ability to activate Mcm helicase on a bubble substrate, we constructed new bubble substrates, Bub82/c-myc, containing sequences derived from the DUE (DNA unwinding element) region of the human c-myc origin which is essential for c-myc replicator activity (29,30)."}

{"project":"2_test","denotations":[{"id":"15917436-7935372-76775525","span":{"begin":351,"end":353},"obj":"7935372"},{"id":"15917436-12589000-76775526","span":{"begin":354,"end":356},"obj":"12589000"}],"text":" In order to examine other natural replication origins with different thymine contents for the ability to activate Mcm helicase on a bubble substrate, we constructed new bubble substrates, Bub82/c-myc, containing sequences derived from the DUE (DNA unwinding element) region of the human c-myc origin which is essential for c-myc replicator activity (29,30)."}