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PMC:1140370 / 19201-20615 JSONTXT

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Id Subject Object Predicate Lexical cue
T5933 0-1 CD denotes 3
T5934 3-12 NN denotes extension
T5935 1-2 SYM denotes ′
T5936 2-3 HYPH denotes -
T5937 35-44 VBN denotes displaced
T5938 13-17 IN denotes with
T5939 18-22 NN denotes poly
T5940 23-25 NN denotes dT
T5941 22-23 -LRB- denotes (
T5942 27-31 NN denotes tail
T5943 25-26 -RRB- denotes )
T5944 32-34 VBZ denotes is
T5945 45-47 IN denotes by
T5946 48-52 NN denotes Mcm4
T5947 52-53 HYPH denotes /
T5948 53-54 CD denotes 6
T5949 54-55 HYPH denotes /
T5950 55-56 CD denotes 7
T5951 56-209 sentence denotes It has been reported that the 3′-extension can be unwound by the archaeal Mcm homohexamer but not by fission and budding yeast Mcm complexes (14,26,27).
T5952 57-59 PRP denotes It
T5953 69-77 VBN denotes reported
T5954 60-63 VBZ denotes has
T5955 64-68 VBN denotes been
T5956 78-82 IN denotes that
T5957 107-114 JJ denotes unwound
T5958 83-86 DT denotes the
T5959 90-99 NN denotes extension
T5960 87-88 CD denotes 3
T5961 88-89 SYM denotes ′
T5962 89-90 HYPH denotes -
T5963 100-103 MD denotes can
T5964 104-106 VB denotes be
T5965 115-117 IN denotes by
T5966 118-121 DT denotes the
T5967 135-146 NN denotes homohexamer
T5968 122-130 JJ denotes archaeal
T5969 131-134 NN denotes Mcm
T5970 147-150 CC denotes but
T5971 151-154 RB denotes not
T5972 155-157 IN denotes by
T5973 158-165 NN denotes fission
T5974 188-197 NNS denotes complexes
T5975 166-169 CC denotes and
T5976 170-177 NN denotes budding
T5977 178-183 NN denotes yeast
T5978 184-187 NN denotes Mcm
T5979 198-199 -LRB- denotes (
T5980 205-207 CD denotes 27
T5981 199-201 CD denotes 14
T5982 201-202 , denotes ,
T5983 202-204 CD denotes 26
T5984 204-205 , denotes ,
T5985 207-208 -RRB- denotes )
T5986 208-209 . denotes .
T5987 209-389 sentence denotes We have constructed 3′-extension substrates containing poly(dT), poly(dA), poly(dC) and poly(dG) 3′-tails in order to examine whether mouse Mcm4/6/7 can displace these substrates.
T5988 210-212 PRP denotes We
T5989 218-229 VBN denotes constructed
T5990 213-217 VBP denotes have
T5991 230-231 CD denotes 3
T5992 233-242 NN denotes extension
T5993 231-232 SYM denotes ′
T5994 232-233 HYPH denotes -
T5995 243-253 NNS denotes substrates
T5996 254-264 VBG denotes containing
T5997 265-269 NN denotes poly
T5998 270-272 NN denotes dT
T5999 269-270 -LRB- denotes (
T6000 310-315 NNS denotes tails
T6001 272-273 -RRB- denotes )
T6002 273-275 , denotes ,
T6003 275-279 NN denotes poly
T6004 280-282 NN denotes dA
T6005 279-280 -LRB- denotes (
T6006 282-283 -RRB- denotes )
T6007 283-285 , denotes ,
T6008 285-289 NN denotes poly
T6009 290-292 NN denotes dC
T6010 289-290 -LRB- denotes (
T6011 292-293 -RRB- denotes )
T6012 294-297 CC denotes and
T6013 298-302 NN denotes poly
T6014 303-305 NN denotes dG
T6015 302-303 -LRB- denotes (
T6016 305-306 -RRB- denotes )
T6017 307-308 CD denotes 3
T6018 308-309 SYM denotes ′
T6019 309-310 HYPH denotes -
T6020 316-318 IN denotes in
T6021 319-324 NN denotes order
T6022 325-327 TO denotes to
T6023 328-335 VB denotes examine
T6024 336-343 IN denotes whether
T6025 363-371 VB denotes displace
T6026 344-349 NN denotes mouse
T6027 350-354 NN denotes Mcm4
T6028 354-355 HYPH denotes /
T6029 355-356 CD denotes 6
T6030 356-357 HYPH denotes /
T6031 357-358 CD denotes 7
T6032 359-362 MD denotes can
T6033 372-377 DT denotes these
T6034 378-388 NNS denotes substrates
T6035 388-389 . denotes .
T6036 389-540 sentence denotes We first found that Mcm4/6/7 binds to dT-, dC- and dG-3′-extension with similar affinity, and to dA-3′-extension with much lower affinity (Figure 5A).
T6037 390-392 PRP denotes We
T6038 399-404 VBD denotes found
T6039 393-398 RB denotes first
T6040 405-409 IN denotes that
T6041 419-424 VBZ denotes binds
T6042 410-414 NN denotes Mcm4
T6043 414-415 HYPH denotes /
T6044 415-416 CD denotes 6
T6045 416-417 HYPH denotes /
T6046 417-418 CD denotes 7
T6047 425-427 IN denotes to
T6048 428-430 NN denotes dT
T6049 447-456 NN denotes extension
T6050 430-431 HYPH denotes -
T6051 431-433 , denotes ,
T6052 433-435 NN denotes dC
T6053 435-436 HYPH denotes -
T6054 437-440 CC denotes and
T6055 441-443 NN denotes dG
T6056 443-444 HYPH denotes -
T6057 444-445 CD denotes 3
T6058 445-446 SYM denotes ′
T6059 446-447 HYPH denotes -
T6060 457-461 IN denotes with
T6061 462-469 JJ denotes similar
T6062 470-478 NN denotes affinity
T6063 478-480 , denotes ,
T6064 480-483 CC denotes and
T6065 484-486 IN denotes to
T6066 487-489 NN denotes dA
T6067 493-502 NN denotes extension
T6068 489-490 HYPH denotes -
T6069 490-491 CD denotes 3
T6070 491-492 SYM denotes ′
T6071 492-493 HYPH denotes -
T6072 503-507 IN denotes with
T6073 508-512 RB denotes much
T6074 513-518 JJR denotes lower
T6075 519-527 NN denotes affinity
T6076 528-529 -LRB- denotes (
T6077 536-538 NN denotes 5A
T6078 529-535 NN denotes Figure
T6079 538-539 -RRB- denotes )
T6080 539-540 . denotes .
T6081 540-671 sentence denotes This is consistent with the previous results that Mcm4/6/7 binds to 50mer oligo-dT, -dC and -dG, but not to a 50mer oligo-dA (13).
T6082 541-545 DT denotes This
T6083 546-548 VBZ denotes is
T6084 549-559 JJ denotes consistent
T6085 560-564 IN denotes with
T6086 565-568 DT denotes the
T6087 578-585 NNS denotes results
T6088 569-577 JJ denotes previous
T6089 586-590 IN denotes that
T6090 600-605 VBZ denotes binds
T6091 591-595 NN denotes Mcm4
T6092 595-596 HYPH denotes /
T6093 596-597 CD denotes 6
T6094 597-598 HYPH denotes /
T6095 598-599 CD denotes 7
T6096 606-608 IN denotes to
T6097 609-614 NN denotes 50mer
T6098 621-623 NN denotes dT
T6099 615-620 NN denotes oligo
T6100 620-621 HYPH denotes -
T6101 623-625 , denotes ,
T6102 625-626 HYPH denotes -
T6103 626-628 NN denotes dC
T6104 629-632 CC denotes and
T6105 633-634 HYPH denotes -
T6106 634-636 NN denotes dG
T6107 636-638 , denotes ,
T6108 638-641 CC denotes but
T6109 642-645 RB denotes not
T6110 646-648 IN denotes to
T6111 649-650 DT denotes a
T6112 663-665 NN denotes dA
T6113 651-656 NN denotes 50mer
T6114 657-662 NN denotes oligo
T6115 662-663 HYPH denotes -
T6116 666-667 -LRB- denotes (
T6117 667-669 CD denotes 13
T6118 669-670 -RRB- denotes )
T6119 670-671 . denotes .
T6120 671-839 sentence denotes We found that dT-tailed 3′-extension was displaced efficiently by Mcm 4/6/7 while almost no or very little activity was detected on other substrates (Figure 5B and C).
T6121 672-674 PRP denotes We
T6122 675-680 VBD denotes found
T6123 681-685 IN denotes that
T6124 713-722 VBN denotes displaced
T6125 686-688 NN denotes dT
T6126 689-695 VBN denotes tailed
T6127 688-689 HYPH denotes -
T6128 699-708 NN denotes extension
T6129 696-697 CD denotes 3
T6130 697-698 SYM denotes ′
T6131 698-699 HYPH denotes -
T6132 709-712 VBD denotes was
T6133 723-734 RB denotes efficiently
T6134 735-737 IN denotes by
T6135 738-741 NN denotes Mcm
T6136 742-743 CD denotes 4
T6137 743-744 HYPH denotes /
T6138 744-745 CD denotes 6
T6139 745-746 HYPH denotes /
T6140 746-747 CD denotes 7
T6141 748-753 IN denotes while
T6142 792-800 VBN denotes detected
T6143 754-760 RB denotes almost
T6144 761-763 DT denotes no
T6145 764-766 CC denotes or
T6146 767-771 RB denotes very
T6147 772-778 JJ denotes little
T6148 779-787 NN denotes activity
T6149 788-791 VBD denotes was
T6150 801-803 IN denotes on
T6151 804-809 JJ denotes other
T6152 810-820 NNS denotes substrates
T6153 821-822 -LRB- denotes (
T6154 829-831 NN denotes 5B
T6155 822-828 NN denotes Figure
T6156 832-835 CC denotes and
T6157 836-837 NN denotes C
T6158 837-838 -RRB- denotes )
T6159 838-839 . denotes .
T6160 839-953 sentence denotes This is in sharp contrast to yeast Mcm4/6/7 helicases which are not capable of unwinding 3′-extension substrates.
T6161 840-844 DT denotes This
T6162 845-847 VBZ denotes is
T6163 848-850 IN denotes in
T6164 851-856 JJ denotes sharp
T6165 857-865 NN denotes contrast
T6166 866-868 IN denotes to
T6167 869-874 NN denotes yeast
T6168 884-893 NNS denotes helicases
T6169 875-879 NN denotes Mcm4
T6170 879-880 HYPH denotes /
T6171 880-881 CD denotes 6
T6172 881-882 HYPH denotes /
T6173 882-883 CD denotes 7
T6174 894-899 WDT denotes which
T6175 900-903 VBP denotes are
T6176 904-907 RB denotes not
T6177 908-915 JJ denotes capable
T6178 916-918 IN denotes of
T6179 919-928 VBG denotes unwinding
T6180 929-930 CD denotes 3
T6181 932-941 NN denotes extension
T6182 930-931 SYM denotes ′
T6183 931-932 HYPH denotes -
T6184 942-952 NNS denotes substrates
T6185 952-953 . denotes .
T6186 953-1059 sentence denotes Furthermore, dT-tailed 5′-extension, to which Mcm4/6/7 could bind, was not displaced by the Mcm helicase.
T6187 954-965 RB denotes Furthermore
T6188 1029-1038 VBN denotes displaced
T6189 965-967 , denotes ,
T6190 967-969 NN denotes dT
T6191 970-976 VBN denotes tailed
T6192 969-970 HYPH denotes -
T6193 980-989 NN denotes extension
T6194 977-978 CD denotes 5
T6195 978-979 SYM denotes ′
T6196 979-980 HYPH denotes -
T6197 989-991 , denotes ,
T6198 991-993 IN denotes to
T6199 1015-1019 VB denotes bind
T6200 994-999 WDT denotes which
T6201 1000-1004 NN denotes Mcm4
T6202 1004-1005 HYPH denotes /
T6203 1005-1006 CD denotes 6
T6204 1006-1007 HYPH denotes /
T6205 1007-1008 CD denotes 7
T6206 1009-1014 MD denotes could
T6207 1019-1021 , denotes ,
T6208 1021-1024 VBD denotes was
T6209 1025-1028 RB denotes not
T6210 1039-1041 IN denotes by
T6211 1042-1045 DT denotes the
T6212 1050-1058 NN denotes helicase
T6213 1046-1049 NN denotes Mcm
T6214 1058-1059 . denotes .
T6215 1059-1250 sentence denotes The addition of the 5′-tail to dT-tailed 3′-extension further stimulated the displacement (Figure 5D), confirming the previous report that the fork structures facilitate the helicase action.
T6216 1060-1063 DT denotes The
T6217 1064-1072 NN denotes addition
T6218 1122-1132 VBD denotes stimulated
T6219 1073-1075 IN denotes of
T6220 1076-1079 DT denotes the
T6221 1083-1087 NN denotes tail
T6222 1080-1081 CD denotes 5
T6223 1081-1082 SYM denotes ′
T6224 1082-1083 HYPH denotes -
T6225 1088-1090 IN denotes to
T6226 1091-1093 NN denotes dT
T6227 1094-1100 VBN denotes tailed
T6228 1093-1094 HYPH denotes -
T6229 1104-1113 NN denotes extension
T6230 1101-1102 CD denotes 3
T6231 1102-1103 SYM denotes ′
T6232 1103-1104 HYPH denotes -
T6233 1114-1121 RB denotes further
T6234 1133-1136 DT denotes the
T6235 1137-1149 NN denotes displacement
T6236 1150-1151 -LRB- denotes (
T6237 1158-1160 NN denotes 5D
T6238 1151-1157 NN denotes Figure
T6239 1160-1161 -RRB- denotes )
T6240 1161-1163 , denotes ,
T6241 1163-1173 VBG denotes confirming
T6242 1174-1177 DT denotes the
T6243 1187-1193 NN denotes report
T6244 1178-1186 JJ denotes previous
T6245 1194-1198 IN denotes that
T6246 1219-1229 VBP denotes facilitate
T6247 1199-1202 DT denotes the
T6248 1208-1218 NNS denotes structures
T6249 1203-1207 NN denotes fork
T6250 1230-1233 DT denotes the
T6251 1243-1249 NN denotes action
T6252 1234-1242 NN denotes helicase
T6253 1249-1250 . denotes .
T6254 1250-1414 sentence denotes Thus, these results further strengthen our conclusion that the mammalian Mcm helicase is generally activated by the thymine-stretch on the 3′-single-stranded tail.
T6255 1251-1255 RB denotes Thus
T6256 1279-1289 VB denotes strengthen
T6257 1255-1257 , denotes ,
T6258 1257-1262 DT denotes these
T6259 1263-1270 NNS denotes results
T6260 1271-1278 RB denotes further
T6261 1290-1293 PRP$ denotes our
T6262 1294-1304 NN denotes conclusion
T6263 1305-1309 IN denotes that
T6264 1350-1359 VBN denotes activated
T6265 1310-1313 DT denotes the
T6266 1328-1336 NN denotes helicase
T6267 1314-1323 JJ denotes mammalian
T6268 1324-1327 NN denotes Mcm
T6269 1337-1339 VBZ denotes is
T6270 1340-1349 RB denotes generally
T6271 1360-1362 IN denotes by
T6272 1363-1366 DT denotes the
T6273 1375-1382 NN denotes stretch
T6274 1367-1374 NN denotes thymine
T6275 1374-1375 HYPH denotes -
T6276 1383-1385 IN denotes on
T6277 1386-1389 DT denotes the
T6278 1409-1413 NN denotes tail
T6279 1390-1391 CD denotes 3
T6280 1391-1392 SYM denotes ′
T6281 1392-1393 HYPH denotes -
T6282 1393-1399 JJ denotes single
T6283 1400-1408 VBN denotes stranded
T6284 1399-1400 HYPH denotes -
T6285 1413-1414 . denotes .
R3967 T5933 T5934 nummod 3,extension
R3968 T5934 T5937 nsubjpass extension,displaced
R3969 T5935 T5933 punct ′,3
R3970 T5936 T5934 punct -,extension
R3971 T5938 T5934 prep with,extension
R3972 T5939 T5940 nmod poly,dT
R3973 T5940 T5942 nmod dT,tail
R3974 T5941 T5940 punct (,dT
R3975 T5942 T5938 pobj tail,with
R3976 T5943 T5942 punct ),tail
R3977 T5944 T5937 auxpass is,displaced
R3978 T5945 T5937 agent by,displaced
R3979 T5946 T5945 pobj Mcm4,by
R3980 T5947 T5946 punct /,Mcm4
R3981 T5948 T5946 nummod 6,Mcm4
R3982 T5949 T5946 punct /,Mcm4
R3983 T5950 T5946 nummod 7,Mcm4
R3984 T5952 T5953 nsubjpass It,reported
R3985 T5954 T5953 aux has,reported
R3986 T5955 T5953 auxpass been,reported
R3987 T5956 T5957 mark that,unwound
R3988 T5957 T5953 ccomp unwound,reported
R3989 T5958 T5959 det the,extension
R3990 T5959 T5957 nsubj extension,unwound
R3991 T5960 T5959 nummod 3,extension
R3992 T5961 T5960 punct ′,3
R3993 T5962 T5959 punct -,extension
R3994 T5963 T5957 aux can,unwound
R3995 T5964 T5957 aux be,unwound
R3996 T5965 T5957 agent by,unwound
R3997 T5966 T5967 det the,homohexamer
R3998 T5967 T5965 pobj homohexamer,by
R3999 T5968 T5967 amod archaeal,homohexamer
R4000 T5969 T5967 compound Mcm,homohexamer
R4001 T5970 T5957 cc but,unwound
R4002 T5971 T5957 conj not,unwound
R4003 T5972 T5971 agent by,not
R4004 T5973 T5974 nmod fission,complexes
R4005 T5974 T5972 pobj complexes,by
R4006 T5975 T5973 cc and,fission
R4007 T5976 T5973 conj budding,fission
R4008 T5977 T5974 compound yeast,complexes
R4009 T5978 T5974 compound Mcm,complexes
R4010 T5979 T5980 punct (,27
R4011 T5980 T5953 parataxis 27,reported
R4012 T5981 T5980 nummod 14,27
R4013 T5982 T5980 punct ",",27
R4014 T5983 T5980 nummod 26,27
R4015 T5984 T5980 punct ",",27
R4016 T5985 T5980 punct ),27
R4017 T5986 T5953 punct .,reported
R4018 T5988 T5989 nsubj We,constructed
R4019 T5990 T5989 aux have,constructed
R4020 T5991 T5992 nummod 3,extension
R4021 T5992 T5995 compound extension,substrates
R4022 T5993 T5991 punct ′,3
R4023 T5994 T5992 punct -,extension
R4024 T5995 T5989 dobj substrates,constructed
R4025 T5996 T5995 acl containing,substrates
R4026 T5997 T5998 nmod poly,dT
R4027 T5998 T6000 nmod dT,tails
R4028 T5999 T5998 punct (,dT
R4029 T6000 T5996 dobj tails,containing
R4030 T6001 T5998 punct ),dT
R4031 T6002 T5998 punct ", ",dT
R4032 T6003 T6004 nmod poly,dA
R4033 T6004 T5998 conj dA,dT
R4034 T6005 T6004 punct (,dA
R4035 T6006 T6004 punct ),dA
R4036 T6007 T6004 punct ", ",dA
R4037 T6008 T6009 nmod poly,dC
R4038 T6009 T6004 conj dC,dA
R4039 T6010 T6009 punct (,dC
R4040 T6011 T6009 punct ),dC
R4041 T6012 T6009 cc and,dC
R4042 T6013 T6014 nmod poly,dG
R4043 T6014 T6009 conj dG,dC
R4044 T6015 T6014 punct (,dG
R4045 T6016 T6014 punct ),dG
R4046 T6017 T6000 nummod 3,tails
R4047 T6018 T6017 punct ′,3
R4048 T6019 T6000 punct -,tails
R4049 T6020 T5989 prep in,constructed
R4050 T6021 T6020 pobj order,in
R4051 T6022 T6023 aux to,examine
R4052 T6023 T6021 acl examine,order
R4053 T6024 T6025 mark whether,displace
R4054 T6025 T6023 ccomp displace,examine
R4055 T6026 T6027 compound mouse,Mcm4
R4056 T6027 T6025 nsubj Mcm4,displace
R4057 T6028 T6027 punct /,Mcm4
R4058 T6029 T6027 nummod 6,Mcm4
R4059 T6030 T6027 punct /,Mcm4
R4060 T6031 T6027 nummod 7,Mcm4
R4061 T6032 T6025 aux can,displace
R4062 T6033 T6034 det these,substrates
R4063 T6034 T6025 dobj substrates,displace
R4064 T6035 T5989 punct .,constructed
R4065 T6037 T6038 nsubj We,found
R4066 T6039 T6038 advmod first,found
R4067 T6040 T6041 mark that,binds
R4068 T6041 T6038 ccomp binds,found
R4069 T6042 T6041 nsubj Mcm4,binds
R4070 T6043 T6042 punct /,Mcm4
R4071 T6044 T6042 nummod 6,Mcm4
R4072 T6045 T6042 punct /,Mcm4
R4073 T6046 T6042 nummod 7,Mcm4
R4074 T6047 T6041 prep to,binds
R4075 T6048 T6049 nmod dT,extension
R4076 T6049 T6047 pobj extension,to
R4077 T6050 T6048 punct -,dT
R4078 T6051 T6048 punct ", ",dT
R4079 T6052 T6048 conj dC,dT
R4080 T6053 T6052 punct -,dC
R4081 T6054 T6052 cc and,dC
R4082 T6055 T6052 conj dG,dC
R4083 T6056 T6049 punct -,extension
R4084 T6057 T6049 nummod 3,extension
R4085 T6058 T6057 punct ′,3
R4086 T6059 T6049 punct -,extension
R4087 T6060 T6041 prep with,binds
R4088 T6061 T6062 amod similar,affinity
R4089 T6062 T6060 pobj affinity,with
R4090 T6063 T6041 punct ", ",binds
R4091 T6064 T6041 cc and,binds
R4092 T6065 T6041 conj to,binds
R4093 T6066 T6067 nmod dA,extension
R4094 T6067 T6065 pobj extension,to
R4095 T6068 T6067 punct -,extension
R4096 T6069 T6067 nummod 3,extension
R4097 T6070 T6069 punct ′,3
R4098 T6071 T6067 punct -,extension
R4099 T6072 T6065 prep with,to
R4100 T6073 T6074 advmod much,lower
R4101 T6074 T6075 amod lower,affinity
R4102 T6075 T6072 pobj affinity,with
R4103 T6076 T6077 punct (,5A
R4104 T6077 T6065 parataxis 5A,to
R4105 T6078 T6077 compound Figure,5A
R4106 T6079 T6077 punct ),5A
R4107 T6080 T6038 punct .,found
R4108 T6082 T6083 nsubj This,is
R4109 T6084 T6083 acomp consistent,is
R4110 T6085 T6084 prep with,consistent
R4111 T6086 T6087 det the,results
R4112 T6087 T6085 pobj results,with
R4113 T6088 T6087 amod previous,results
R4114 T6089 T6090 mark that,binds
R4115 T6090 T6087 acl binds,results
R4116 T6091 T6090 nsubj Mcm4,binds
R4117 T6092 T6091 punct /,Mcm4
R4118 T6093 T6091 nummod 6,Mcm4
R4119 T6094 T6091 punct /,Mcm4
R4120 T6095 T6091 nummod 7,Mcm4
R4121 T6096 T6090 prep to,binds
R4122 T6097 T6098 compound 50mer,dT
R4123 T6098 T6096 pobj dT,to
R4124 T6099 T6098 compound oligo,dT
R4125 T6100 T6098 punct -,dT
R4126 T6101 T6098 punct ", ",dT
R4127 T6102 T6103 punct -,dC
R4128 T6103 T6098 conj dC,dT
R4129 T6104 T6103 cc and,dC
R4130 T6105 T6106 punct -,dG
R4131 T6106 T6103 conj dG,dC
R4132 T6107 T6096 punct ", ",to
R4133 T6108 T6096 cc but,to
R4134 T6109 T6108 neg not,but
R4135 T6110 T6096 conj to,to
R4136 T6111 T6112 det a,dA
R4137 T6112 T6110 pobj dA,to
R4138 T6113 T6112 compound 50mer,dA
R4139 T6114 T6112 compound oligo,dA
R4140 T6115 T6112 punct -,dA
R4141 T6116 T6117 punct (,13
R4142 T6117 T6083 parataxis 13,is
R4143 T6118 T6117 punct ),13
R4144 T6119 T6083 punct .,is
R4145 T6121 T6122 nsubj We,found
R4146 T6123 T6124 mark that,displaced
R4147 T6124 T6122 ccomp displaced,found
R4148 T6125 T6126 npadvmod dT,tailed
R4149 T6126 T6128 amod tailed,extension
R4150 T6127 T6126 punct -,tailed
R4151 T6128 T6124 nsubjpass extension,displaced
R4152 T6129 T6128 nummod 3,extension
R4153 T6130 T6129 punct ′,3
R4154 T6131 T6128 punct -,extension
R4155 T6132 T6124 auxpass was,displaced
R4156 T6133 T6124 advmod efficiently,displaced
R4157 T6134 T6124 agent by,displaced
R4158 T6135 T6134 pobj Mcm,by
R4159 T6136 T6135 nummod 4,Mcm
R4160 T6137 T6135 punct /,Mcm
R4161 T6138 T6135 nummod 6,Mcm
R4162 T6139 T6135 punct /,Mcm
R4163 T6140 T6135 nummod 7,Mcm
R4164 T6141 T6142 mark while,detected
R4165 T6142 T6124 advcl detected,displaced
R4166 T6143 T6144 advmod almost,no
R4167 T6144 T6142 nsubjpass no,detected
R4168 T6145 T6144 cc or,no
R4169 T6146 T6147 advmod very,little
R4170 T6147 T6148 nmod little,activity
R4171 T6148 T6144 conj activity,no
R4172 T6149 T6142 auxpass was,detected
R4173 T6150 T6142 prep on,detected
R4174 T6151 T6152 amod other,substrates
R4175 T6152 T6150 pobj substrates,on
R4176 T6153 T6154 punct (,5B
R4177 T6154 T6142 parataxis 5B,detected
R4178 T6155 T6154 compound Figure,5B
R4179 T6156 T6154 cc and,5B
R4180 T6157 T6154 conj C,5B
R4181 T6158 T6154 punct ),5B
R4182 T6159 T6122 punct .,found
R4183 T6161 T6162 nsubj This,is
R4184 T6163 T6162 prep in,is
R4185 T6164 T6165 amod sharp,contrast
R4186 T6165 T6163 pobj contrast,in
R4187 T6166 T6165 prep to,contrast
R4188 T6167 T6168 nmod yeast,helicases
R4189 T6168 T6166 pobj helicases,to
R4190 T6169 T6168 nmod Mcm4,helicases
R4191 T6170 T6169 punct /,Mcm4
R4192 T6171 T6169 nummod 6,Mcm4
R4193 T6172 T6169 punct /,Mcm4
R4194 T6173 T6169 nummod 7,Mcm4
R4195 T6174 T6175 dep which,are
R4196 T6175 T6168 relcl are,helicases
R4197 T6176 T6175 neg not,are
R4198 T6177 T6175 acomp capable,are
R4199 T6178 T6177 prep of,capable
R4200 T6179 T6178 pcomp unwinding,of
R4201 T6180 T6181 nummod 3,extension
R4202 T6181 T6184 compound extension,substrates
R4203 T6182 T6180 punct ′,3
R4204 T6183 T6181 punct -,extension
R4205 T6184 T6179 dobj substrates,unwinding
R4206 T6185 T6162 punct .,is
R4207 T6187 T6188 advmod Furthermore,displaced
R4208 T6189 T6188 punct ", ",displaced
R4209 T6190 T6191 npadvmod dT,tailed
R4210 T6191 T6193 amod tailed,extension
R4211 T6192 T6191 punct -,tailed
R4212 T6193 T6188 nsubjpass extension,displaced
R4213 T6194 T6193 nummod 5,extension
R4214 T6195 T6194 punct ′,5
R4215 T6196 T6193 punct -,extension
R4216 T6197 T6193 punct ", ",extension
R4217 T6198 T6199 prep to,bind
R4218 T6199 T6193 relcl bind,extension
R4219 T6200 T6198 pobj which,to
R4220 T6201 T6199 nsubj Mcm4,bind
R4221 T6202 T6201 punct /,Mcm4
R4222 T6203 T6201 nummod 6,Mcm4
R4223 T6204 T6201 punct /,Mcm4
R4224 T6205 T6201 nummod 7,Mcm4
R4225 T6206 T6199 aux could,bind
R4226 T6207 T6188 punct ", ",displaced
R4227 T6208 T6188 auxpass was,displaced
R4228 T6209 T6188 neg not,displaced
R4229 T6210 T6188 agent by,displaced
R4230 T6211 T6212 det the,helicase
R4231 T6212 T6210 pobj helicase,by
R4232 T6213 T6212 compound Mcm,helicase
R4233 T6214 T6188 punct .,displaced
R4234 T6216 T6217 det The,addition
R4235 T6217 T6218 nsubj addition,stimulated
R4236 T6219 T6217 prep of,addition
R4237 T6220 T6221 det the,tail
R4238 T6221 T6219 pobj tail,of
R4239 T6222 T6221 nummod 5,tail
R4240 T6223 T6222 punct ′,5
R4241 T6224 T6221 punct -,tail
R4242 T6225 T6217 prep to,addition
R4243 T6226 T6227 npadvmod dT,tailed
R4244 T6227 T6229 amod tailed,extension
R4245 T6228 T6227 punct -,tailed
R4246 T6229 T6225 pobj extension,to
R4247 T6230 T6229 nummod 3,extension
R4248 T6231 T6230 punct ′,3
R4249 T6232 T6229 punct -,extension
R4250 T6233 T6218 advmod further,stimulated
R4251 T6234 T6235 det the,displacement
R4252 T6235 T6218 dobj displacement,stimulated
R4253 T6236 T6237 punct (,5D
R4254 T6237 T6235 parataxis 5D,displacement
R4255 T6238 T6237 compound Figure,5D
R4256 T6239 T6237 punct ),5D
R4257 T6240 T6218 punct ", ",stimulated
R4258 T6241 T6218 advcl confirming,stimulated
R4259 T6242 T6243 det the,report
R4260 T6243 T6241 dobj report,confirming
R4261 T6244 T6243 amod previous,report
R4262 T6245 T6246 mark that,facilitate
R4263 T6246 T6243 acl facilitate,report
R4264 T6247 T6248 det the,structures
R4265 T6248 T6246 nsubj structures,facilitate
R4266 T6249 T6248 compound fork,structures
R4267 T6250 T6251 det the,action
R4268 T6251 T6246 dobj action,facilitate
R4269 T6252 T6251 compound helicase,action
R4270 T6253 T6218 punct .,stimulated
R4271 T6255 T6256 advmod Thus,strengthen
R4272 T6257 T6256 punct ", ",strengthen
R4273 T6258 T6259 det these,results
R4274 T6259 T6256 nsubj results,strengthen
R4275 T6260 T6256 advmod further,strengthen
R4276 T6261 T6262 poss our,conclusion
R4277 T6262 T6256 dobj conclusion,strengthen
R4278 T6263 T6264 mark that,activated
R4279 T6264 T6262 acl activated,conclusion
R4280 T6265 T6266 det the,helicase
R4281 T6266 T6264 nsubjpass helicase,activated
R4282 T6267 T6266 amod mammalian,helicase
R4283 T6268 T6266 compound Mcm,helicase
R4284 T6269 T6264 auxpass is,activated
R4285 T6270 T6264 advmod generally,activated
R4286 T6271 T6264 agent by,activated
R4287 T6272 T6273 det the,stretch
R4288 T6273 T6271 pobj stretch,by
R4289 T6274 T6273 compound thymine,stretch
R4290 T6275 T6273 punct -,stretch
R4291 T6276 T6273 prep on,stretch
R4292 T6277 T6278 det the,tail
R4293 T6278 T6276 pobj tail,on
R4294 T6279 T6278 nummod 3,tail
R4295 T6280 T6279 punct ′,3
R4296 T6281 T6278 punct -,tail
R4297 T6282 T6283 amod single,stranded
R4298 T6283 T6278 amod stranded,tail
R4299 T6284 T6283 punct -,stranded
R4300 T6285 T6256 punct .,strengthen

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5866 0-12 GO:0006272 denotes 3′-extension
T5867 23-25 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5868 48-52 PR_EXT:000010246 denotes Mcm4
T5869 48-56 GO:0097373 denotes Mcm4/6/7
T5870 87-99 GO:0006272 denotes 3′-extension
T5871 122-130 NCBITaxon:2157 denotes archaeal
T5872 131-134 GO:0042555 denotes Mcm
T5873 139-146 GO_EXT:hexameric_macromolecular_complex denotes hexamer
T5874 158-165 _FRAGMENT denotes fission
T5875 178-183 NCBITaxon:4894 denotes yeast
T5876 170-177 GO:0007114 denotes budding
T5877 170-183 NCBITaxon:4892 denotes budding yeast
T5878 184-197 GO:0042555 denotes Mcm complexes
T5879 230-242 GO:0006272 denotes 3′-extension
T5880 270-272 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5881 280-282 CHEBI_EXT:deoxyadenosine_nucleoside_or_nucleotide_residue denotes dA
T5882 290-292 CHEBI_EXT:deoxycytidine_nucleoside_or_nucleotide_residue denotes dC
T5883 303-305 CHEBI_EXT:deoxyguanosine_nucleoside_or_nucleotide_residue denotes dG
T5884 344-349 NCBITaxon:10088 denotes mouse
T5885 350-354 PR_EXT:000010246 denotes Mcm4
T5886 350-358 GO:0097373 denotes Mcm4/6/7
T5887 410-414 PR_EXT:000010246 denotes Mcm4
T5888 410-418 GO:0097373 denotes Mcm4/6/7
T5889 419-424 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T5890 428-430 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5891 433-435 CHEBI_EXT:deoxycytidine_nucleoside_or_nucleotide_residue denotes dC
T5892 441-443 CHEBI_EXT:deoxyguanosine_nucleoside_or_nucleotide_residue denotes dG
T5893 444-456 GO:0006272 denotes 3′-extension
T5894 487-489 CHEBI_EXT:deoxyadenosine_nucleoside_or_nucleotide_residue denotes dA
T5895 490-502 GO:0006272 denotes 3′-extension
T5896 591-595 PR_EXT:000010246 denotes Mcm4
T5897 591-599 GO:0097373 denotes Mcm4/6/7
T5898 600-605 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T5899 615-620 CHEBI_SO_EXT:oligonucleotide denotes oligo
T5900 621-623 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5901 626-628 CHEBI_EXT:deoxycytidine_nucleoside_or_nucleotide_residue denotes dC
T5902 634-636 CHEBI_EXT:deoxyguanosine_nucleoside_or_nucleotide_residue denotes dG
T5903 657-662 CHEBI_SO_EXT:oligonucleotide denotes oligo
T5904 663-665 CHEBI_EXT:deoxyadenosine_nucleoside_or_nucleotide_residue denotes dA
T5905 686-688 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5906 696-708 GO:0006272 denotes 3′-extension
T5907 738-743 PR_EXT:000010246 denotes Mcm 4
T5908 738-741 _FRAGMENT denotes Mcm
T5909 744-745 PR_EXT:000010248 denotes 6
T5910 746-747 PR_EXT:000010249 denotes 7
T5911 738-747 GO:0097373 denotes Mcm 4/6/7
T5912 869-874 NCBITaxon_EXT:yeast denotes yeast
T5913 875-879 PR_EXT:000010246 denotes Mcm4
T5914 875-883 GO:0097373 denotes Mcm4/6/7
T5915 884-893 GO_EXT:0004386 denotes helicases
T5916 929-941 GO:0006272 denotes 3′-extension
T5917 967-969 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5918 977-989 GO:0006273 denotes 5′-extension
T5919 1000-1004 PR_EXT:000010246 denotes Mcm4
T5920 1000-1008 GO:0097373 denotes Mcm4/6/7
T5921 1015-1019 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T5922 1046-1049 GO:0042555 denotes Mcm
T5923 1050-1058 GO_EXT:0004386 denotes helicase
T5924 1091-1093 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes dT
T5925 1101-1113 GO:0006272 denotes 3′-extension
T5926 1203-1207 GO:0005657 denotes fork
T5927 1234-1242 GO_EXT:0004386 denotes helicase
T5928 1314-1323 NCBITaxon:40674 denotes mammalian
T5929 1324-1327 GO:0042555 denotes Mcm
T5930 1328-1336 GO_EXT:0004386 denotes helicase
T5931 1367-1374 CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group denotes thymine
T5932 1393-1408 SO:0000984 denotes single-stranded
R3964 T5875 T5874 _lexicallyChainedTo yeast,fission
R3965 T5909 T5908 _lexicallyChainedTo 6,Mcm
R3966 T5910 T5908 _lexicallyChainedTo 7,Mcm

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T5827 0-12 GO:0006272 denotes 3′-extension
T5828 48-52 PR:000010246 denotes Mcm4
T5829 48-56 GO:0097373 denotes Mcm4/6/7
T5830 87-99 GO:0006272 denotes 3′-extension
T5831 122-130 NCBITaxon:2157 denotes archaeal
T5832 131-134 GO:0042555 denotes Mcm
T5833 158-165 _FRAGMENT denotes fission
T5834 178-183 NCBITaxon:4894 denotes yeast
T5835 170-177 GO:0007114 denotes budding
T5836 170-183 NCBITaxon:4892 denotes budding yeast
T5837 184-197 GO:0042555 denotes Mcm complexes
T5838 230-242 GO:0006272 denotes 3′-extension
T5839 344-349 NCBITaxon:10088 denotes mouse
T5840 350-354 PR:000010246 denotes Mcm4
T5841 350-358 GO:0097373 denotes Mcm4/6/7
T5842 410-414 PR:000010246 denotes Mcm4
T5843 410-418 GO:0097373 denotes Mcm4/6/7
T5844 444-456 GO:0006272 denotes 3′-extension
T5845 490-502 GO:0006272 denotes 3′-extension
T5846 591-595 PR:000010246 denotes Mcm4
T5847 591-599 GO:0097373 denotes Mcm4/6/7
T5848 696-708 GO:0006272 denotes 3′-extension
T5849 738-743 PR:000010246 denotes Mcm 4
T5850 738-741 _FRAGMENT denotes Mcm
T5851 744-745 PR:000010248 denotes 6
T5852 746-747 PR:000010249 denotes 7
T5853 738-747 GO:0097373 denotes Mcm 4/6/7
T5854 875-879 PR:000010246 denotes Mcm4
T5855 875-883 GO:0097373 denotes Mcm4/6/7
T5856 929-941 GO:0006272 denotes 3′-extension
T5857 977-989 GO:0006273 denotes 5′-extension
T5858 1000-1004 PR:000010246 denotes Mcm4
T5859 1000-1008 GO:0097373 denotes Mcm4/6/7
T5860 1046-1049 GO:0042555 denotes Mcm
T5861 1101-1113 GO:0006272 denotes 3′-extension
T5862 1203-1207 GO:0005657 denotes fork
T5863 1314-1323 NCBITaxon:40674 denotes mammalian
T5864 1324-1327 GO:0042555 denotes Mcm
T5865 1393-1408 SO:0000984 denotes single-stranded
R3961 T5834 T5833 _lexicallyChainedTo yeast,fission
R3962 T5851 T5850 _lexicallyChainedTo 6,Mcm
R3963 T5852 T5850 _lexicallyChainedTo 7,Mcm

2_test

Id Subject Object Predicate Lexical cue
15917436-11136247-76775518 199-201 11136247 denotes 14
15917436-13679365-76775519 202-204 13679365 denotes 26
15917436-12975364-76775520 205-207 12975364 denotes 27
15917436-14609960-76775521 667-669 14609960 denotes 13