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PMC:1134658 / 1403-4028 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1193 289-297 NN denotes proteins
T1194 298-299 -LRB- denotes (
T1195 299-303 NN denotes BMPs
T1196 303-304 -RRB- denotes )
T1197 304-305 -COMMA- denotes ,
T1198 306-308 IN denotes of
T1199 309-314 WDT denotes which
T1200 315-318 DT denotes the
T1201 319-325 JJ denotes latter
T1202 326-336 NN denotes constitute
T1203 337-340 DT denotes the
T1204 341-348 JJ denotes largest
T1205 349-355 NN denotes family
T1206 357-361 NN denotes BMPs
T1207 362-365 VB denotes are
T1208 366-371 CD denotes 30–38
T1209 372-375 NN denotes kDa
T1210 376-383 NN denotes hetero-
T1211 384-386 CC denotes or
T1212 387-398 JJ denotes homodimeric
T1213 399-407 NN denotes proteins
T1214 408-418 RB denotes originally
T1215 419-429 VB denotes identified
T1216 430-432 IN denotes by
T1217 433-438 PRP-DOLLAR- denotes their
T1218 439-446 NN denotes ability
T1219 447-449 TO denotes to
T1220 450-456 VB denotes induce
T1221 457-464 JJ denotes ectopic
T1222 465-474 NN denotes cartilage
T1223 475-478 CC denotes and
T1224 479-483 NN denotes bone
T1225 484-493 NN denotes formation
T1226 494-495 -LRB- denotes [
T1227 495-498 CD denotes 2,3
T1228 498-499 -RRB- denotes ]
T1229 501-508 JJ denotes Several
T1230 509-516 NN denotes studies
T1231 517-521 VB denotes have
T1232 522-534 VB denotes demonstrated
T1233 535-537 DT denotes an
T1234 538-547 JJ denotes essential
T1235 548-552 NN denotes role
T1236 553-555 IN denotes of
T1237 556-561 DT denotes these
T1238 562-570 NN denotes proteins
T1239 571-577 IN denotes during
T1240 578-591 NN denotes embryogenesis
T1241 591-592 -COMMA- denotes ,
T1242 593-596 CC denotes and
T1243 597-601 RB denotes more
T1244 602-610 RB denotes recently
T1245 610-611 -COMMA- denotes ,
T1246 612-616 RB denotes also
T1247 617-619 IN denotes in
T1248 620-625 JJ denotes adult
T1249 626-633 NN denotes tissues
T1250 634-635 -LRB- denotes [
T1251 635-636 CD denotes 1
T1252 636-637 -RRB- denotes ]
T1253 639-644 NN denotes TGF-β
T1254 645-648 VB denotes has
T1255 649-653 VB denotes been
T1256 654-665 RB denotes intensively
T1257 666-673 VB denotes studied
T1258 674-676 IN denotes in
T1259 677-683 JJ denotes normal
T1260 684-687 CC denotes and
T1261 688-697 JJ denotes malignant
T1262 698-712 JJ denotes haematopoietic
T1263 713-718 NN denotes cells
T1264 719-722 CC denotes and
T1265 723-725 VB denotes is
T1266 726-729 CD denotes one
T1267 730-732 IN denotes of
T1268 733-736 DT denotes the
T1269 737-741 RB denotes most
T1270 742-748 JJ denotes potent
T1271 749-759 JJ denotes endogenous
T1272 760-768 JJ denotes negative
T1273 769-779 NN denotes regulators
T1274 780-785 VB denotes known
T1275 786-788 TO denotes to
T1276 789-794 NN denotes date.
T1277 795-796 -LRB- denotes [
T1278 796-797 CD denotes 4
T1279 797-798 -RRB- denotes ]
T1280 800-802 IN denotes In
T1281 803-811 NN denotes contrast
T1282 811-812 -COMMA- denotes ,
T1283 813-816 DT denotes the
T1284 817-823 NN denotes effect
T1285 824-826 IN denotes of
T1286 827-831 NN denotes BMPs
T1287 832-834 IN denotes in
T1288 835-838 DT denotes the
T1289 839-845 JJ denotes immune
T1290 846-852 NN denotes system
T1291 853-856 VB denotes has
T1292 857-860 RB denotes not
T1293 861-865 VB denotes been
T1294 866-872 RB denotes widely
T1295 873-885 VB denotes investigated
T1296 887-889 IN denotes In
T1297 890-894 DT denotes that
T1298 895-902 NN denotes respect
T1299 902-903 -COMMA- denotes ,
T1300 904-908 NN denotes BMP-
T1301 909-910 CD denotes 2
T1302 910-911 -COMMA- denotes ,
T1303 912-914 CD denotes -4
T1304 915-918 CC denotes and
T1305 919-921 CD denotes -7
T1306 922-926 VB denotes have
T1307 927-931 VB denotes been
T1308 932-937 VB denotes found
T1309 938-940 TO denotes to
T1310 941-948 VB denotes control
T1311 949-964 NN denotes differentiation
T1312 965-967 IN denotes of
T1313 968-981 JJ denotes hematopoietic
T1314 982-986 NN denotes stem
T1315 987-992 NN denotes cells
T1316 993-994 -LRB- denotes [
T1317 994-995 CD denotes 5
T1318 995-996 -RRB- denotes ]
T1319 997-1000 CC denotes and
T1320 1001-1006 JJ denotes early
T1321 1007-1008 NN denotes T
T1322 1009-1013 NN denotes cell
T1323 1014-1025 NN denotes development
T1324 1026-1027 -LRB- denotes [
T1325 1027-1030 CD denotes 6,7
T1326 1030-1031 -RRB- denotes ]
T1327 1033-1038 NN denotes BMP-6
T1328 1039-1042 VB denotes has
T1329 1043-1047 VB denotes been
T1330 1048-1056 VB denotes reported
T1331 1057-1059 TO denotes to
T1332 1060-1066 VB denotes reduce
T1333 1067-1070 DT denotes the
T1334 1071-1077 NN denotes number
T1335 1078-1080 IN denotes of
T1336 1081-1105 JJ denotes cobblestone-area-forming
T1337 1106-1111 NN denotes cells
T1338 1112-1114 IN denotes of
T1339 1115-1121 JJ denotes normal
T1340 1122-1127 JJ denotes human
T1341 1128-1142 JJ denotes haematopoietic
T1342 1143-1148 NN denotes cells
T1343 1149-1150 -LRB- denotes [
T1344 1150-1151 CD denotes 8
T1345 1151-1152 -RRB- denotes ]
T1346 1154-1165 RB denotes Furthermore
T1347 1165-1166 -COMMA- denotes ,
T1348 1167-1172 NN denotes BMP-2
T1349 1172-1173 -COMMA- denotes ,
T1350 1174-1176 CD denotes -4
T1351 1176-1177 -COMMA- denotes ,
T1352 1178-1179 CD denotes 6
T1353 1180-1183 CC denotes and
T1354 1184-1186 CD denotes -7
T1355 1187-1190 VB denotes had
T1356 1191-1193 DT denotes an
T1357 1194-1211 JJ denotes antiproliferative
T1358 1212-1215 CC denotes and
T1359 1216-1217 DT denotes a
T1360 1218-1230 JJ denotes proapoptotic
T1361 1231-1237 NN denotes effect
T1362 1238-1240 IN denotes on
T1363 1241-1249 JJ denotes multiple
T1364 1250-1257 NN denotes myeloma
T1365 1258-1263 NN denotes cells
T1366 1264-1265 -LRB- denotes [
T1367 1265-1269 CD denotes 9-11
T1368 1269-1270 -RRB- denotes ]
T1369 1272-1274 IN denotes In
T1370 1275-1283 NN denotes addition
T1371 1283-1284 -COMMA- denotes ,
T1372 1285-1287 IN denotes by
T1373 1288-1292 NN denotes gene
T1374 1293-1303 NN denotes expression
T1375 1304-1313 NN denotes profiling
T1376 1313-1314 -COMMA- denotes ,
T1377 1315-1320 NN denotes BMP-6
T1378 1321-1334 RB denotes significantly
T1379 1335-1344 VB denotes increased
T1380 1345-1348 DT denotes the
T1381 1349-1359 JJ denotes predictive
T1382 1360-1365 NN denotes value
T1383 1366-1369 IN denotes for
T1384 1370-1371 DT denotes a
T1385 1372-1382 JJ denotes multi-gene
T1386 1383-1392 NN denotes signature
T1387 1393-1397 NN denotes test
T1388 1398-1401 CC denotes and
T1389 1402-1405 VB denotes was
T1390 1406-1416 VB denotes associated
T1391 1417-1421 IN denotes with
T1392 1422-1423 DT denotes a
T1393 1424-1428 JJ denotes poor
T1394 1429-1436 NN denotes outcome
T1395 1437-1439 IN denotes in
T1396 1440-1447 JJ denotes diffuse
T1397 1448-1453 JJ denotes large
T1398 1454-1455 NN denotes B
T1399 1456-1460 NN denotes cell
T1400 1461-1470 NN denotes lymphomas
T1401 1471-1472 -LRB- denotes (
T1402 1472-1477 NN denotes DLBCL
T1403 1477-1478 -RRB- denotes )
T1404 1479-1480 -LRB- denotes [
T1405 1480-1482 CD denotes 12
T1406 1482-1483 -RRB- denotes ]
T1407 1485-1490 NN denotes BMP-6
T1408 1490-1491 -COMMA- denotes ,
T1409 1492-1496 IN denotes like
T1410 1497-1500 DT denotes the
T1411 1501-1506 JJ denotes other
T1412 1507-1510 NN denotes BMP
T1413 1511-1518 NN denotes members
T1414 1518-1519 -COMMA- denotes ,
T1415 1520-1527 NN denotes signals
T1416 1528-1535 IN denotes through
T1417 1536-1544 NN denotes ligation
T1418 1545-1548 CC denotes and
T1419 1549-1566 NN denotes heterodimerzation
T1420 1567-1569 IN denotes of
T1421 1570-1573 NN denotes BMP
T1422 1574-1578 NN denotes type
T1423 1579-1580 CD denotes I
T1424 1581-1582 -LRB- denotes [
T1425 1582-1601 NN denotes activin-like-kinase
T1426 1602-1603 -LRB- denotes (
T1427 1603-1606 NN denotes ALK
T1428 1606-1607 -RRB- denotes )
T1429 1607-1608 -RRB- denotes ]
T1430 1609-1612 CC denotes and
T1431 1613-1617 NN denotes type
T1432 1618-1620 CD denotes II
T1433 1621-1637 NN denotes serine-threonine
T1434 1638-1644 NN denotes kinase
T1435 1645-1654 NN denotes receptors
T1436 1654-1655 -COMMA- denotes ,
T1437 1656-1661 WDT denotes which
T1438 1662-1674 RB denotes subsequently
T1439 1675-1685 VB denotes propagates
T1440 1686-1689 DT denotes the
T1441 1690-1696 NN denotes signal
T1442 1697-1707 RB denotes downstream
T1443 1708-1710 IN denotes by
T1444 1711-1726 VB denotes phosphorylating
T1445 1727-1731 NN denotes Smad
T1446 1732-1740 NN denotes proteins
T1447 1742-1747 NN denotes BMP-6
T1448 1748-1751 MD denotes can
T1449 1752-1758 VB denotes signal
T1450 1759-1766 IN denotes through
T1451 1767-1770 DT denotes the
T1452 1771-1779 NN denotes ligation
T1453 1780-1782 IN denotes of
T1454 1783-1786 DT denotes the
T1455 1787-1791 NN denotes type
T1456 1792-1793 CD denotes I
T1457 1794-1803 NN denotes receptors
T1458 1804-1811 NNP denotes Act-RIA
T1459 1811-1812 -COMMA- denotes ,
T1460 1813-1820 NN denotes BMP-RIA
T1461 1820-1821 -COMMA- denotes ,
T1462 1822-1825 CC denotes and
T1463 1826-1833 NN denotes BMP-RIB
T1464 1834-1837 CC denotes and
T1465 1838-1841 DT denotes the
T1466 1842-1846 NN denotes type
T1467 1847-1849 CD denotes II
T1468 1850-1859 NN denotes receptors
T1469 1860-1867 NN denotes BMP-RII
T1470 1867-1868 -COMMA- denotes ,
T1471 1869-1877 NN denotes Act-RIIA
T1472 1878-1881 CC denotes and
T1473 1882-1890 NN denotes Act-RIIB
T1474 1890-1891 -COMMA- denotes ,
T1475 1892-1897 WDT denotes which
T1476 1898-1902 VB denotes lead
T1477 1903-1905 TO denotes to
T1478 1906-1909 DT denotes the
T1479 1910-1925 NN denotes phosphorylation
T1480 1926-1928 IN denotes of
T1481 1929-1932 DT denotes the
T1482 1933-1941 NN denotes receptor
T1483 1942-1947 NN denotes Smads
T1484 1948-1949 -LRB- denotes (
T1485 1949-1955 NN denotes Smad-1
T1486 1955-1956 -COMMA- denotes ,
T1487 1957-1963 NN denotes Smad-5
T1488 1963-1964 -COMMA- denotes ,
T1489 1965-1968 CC denotes and
T1490 1969-1975 NN denotes Smad-8
T1491 1975-1976 -RRB- denotes )
T1492 1978-1981 DT denotes The
T1493 1982-1984 NN denotes R-
T1494 1985-1990 NN denotes Smads
T1495 1991-1995 RB denotes then
T1496 1996-2000 VB denotes form
T1497 2001-2010 NN denotes complexes
T1498 2011-2015 IN denotes with
T1499 2016-2019 DT denotes the
T1500 2020-2027 NN denotes co-Smad
T1501 2028-2029 -LRB- denotes (
T1502 2029-2034 NN denotes Smad4
T1503 2034-2035 -RRB- denotes )
T1504 2036-2039 CC denotes and
T1505 2040-2043 VB denotes are
T1506 2044-2056 VB denotes translocated
T1507 2057-2061 IN denotes into
T1508 2062-2065 DT denotes the
T1509 2066-2073 NN denotes nucleus
T1510 2074-2079 WRB denotes where
T1511 2080-2084 PRP denotes they
T1512 2085-2090 VB denotes exert
T1513 2091-2095 NN denotes gene
T1514 2096-2106 NN denotes regulation
T1515 2107-2108 -LRB- denotes [
T1516 2108-2112 CD denotes 1,13
T1517 2112-2113 -RRB- denotes ]
T1518 2115-2120 VB denotes Given
T1519 2121-2124 DT denotes the
T1520 2125-2133 VB denotes reported
T1521 2134-2138 NN denotes role
T1522 2139-2141 IN denotes of
T1523 2142-2147 NN denotes BMP-6
T1524 2148-2150 IN denotes in
T1525 2151-2157 NN denotes B-cell
T1526 2158-2170 NN denotes malignancies
T1527 2171-2174 CC denotes and
T1528 2175-2189 JJ denotes haematopoietic
T1529 2190-2200 NN denotes progenitor
T1530 2201-2206 NN denotes cells
T1531 2206-2207 -COMMA- denotes ,
T1532 2208-2210 PRP denotes we
T1533 2211-2217 VB denotes wanted
T1534 2218-2220 TO denotes to
T1535 2221-2228 VB denotes explore
T1536 2229-2232 PRP-DOLLAR- denotes its
T1537 2233-2242 JJ denotes potential
T1538 2243-2247 NN denotes role
T1539 2248-2250 IN denotes in
T1540 2251-2257 JJ denotes normal
T1541 2258-2263 JJ denotes human
T1542 2264-2265 NN denotes B
T1543 2266-2271 NN denotes cells
T1544 2273-2275 PRP denotes We
T1545 2276-2283 VB denotes studied
T1546 2284-2287 DT denotes the
T1547 2288-2295 NN denotes effects
T1548 2296-2298 IN denotes of
T1549 2299-2304 NN denotes BMP-6
T1550 2305-2307 IN denotes on
T1551 2308-2321 NN denotes proliferation
T1552 2322-2325 CC denotes and
T1553 2326-2335 NN denotes apoptosis
T1554 2336-2338 IN denotes on
T1555 2339-2346 VB denotes resting
T1556 2347-2350 CC denotes and
T1557 2351-2361 VB denotes stimulated
T1558 2362-2363 NN denotes B
T1559 2364-2369 NN denotes cells
T1560 2371-2382 RB denotes Furthermore
T1561 2382-2383 -COMMA- denotes ,
T1562 2384-2387 DT denotes the
T1563 2388-2398 NN denotes expression
T1564 2399-2401 IN denotes of
T1565 2402-2405 NN denotes BMP
T1566 2406-2415 NN denotes receptors
T1567 2416-2419 CC denotes and
T1568 2420-2425 NN denotes BMP-6
T1569 2426-2433 VB denotes induced
T1570 2434-2444 NN denotes activation
T1571 2445-2447 IN denotes of
T1572 2448-2451 DT denotes the
T1573 2452-2456 NN denotes Smad
T1574 2457-2467 NN denotes signalling
T1575 2468-2475 NN denotes pathway
T1576 2476-2480 IN denotes with
T1577 2481-2491 JJ denotes subsequent
T1578 2492-2502 NN denotes regulation
T1579 2503-2505 IN denotes of
T1580 2506-2509 DT denotes the
T1581 2510-2516 NN denotes target
T1582 2517-2522 NN denotes genes
T1583 2523-2530 NN denotes Id1–Id4
T1584 2530-2531 -COMMA- denotes ,
T1585 2532-2536 VB denotes were
T1586 2537-2545 VB denotes resolved
T1587 2547-2554 RB denotes Finally
T1588 2554-2555 -COMMA- denotes ,
T1589 2556-2558 PRP denotes we
T1590 2559-2571 VB denotes investigated
T1591 2572-2579 IN denotes whether
T1592 2580-2581 NN denotes B
T1593 2582-2587 NN denotes cells
T1594 2588-2592 RB denotes also
T1595 2593-2597 VB denotes were
T1596 2598-2605 JJ denotes capable
T1597 2606-2608 IN denotes of
T1598 2609-2618 VB denotes producing
T1599 2619-2624 NN denotes BMP-6
T1148 11-18 NN denotes Members
T1149 19-21 IN denotes of
T1150 22-25 DT denotes the
T1151 26-38 VB denotes transforming
T1152 39-45 NN denotes growth
T1153 46-52 NN denotes factor
T1154 53-54 NN denotes β
T1155 55-56 -LRB- denotes (
T1156 56-61 NN denotes TGF-β
T1157 61-62 -RRB- denotes )
T1158 63-74 NN denotes superfamily
T1159 75-79 VB denotes play
T1160 80-87 JJ denotes central
T1161 88-93 NN denotes roles
T1162 94-96 IN denotes in
T1163 97-108 VB denotes controlling
T1164 109-117 JJ denotes cellular
T1165 118-131 NN denotes proliferation
T1166 131-132 -COMMA- denotes ,
T1167 133-148 NN denotes differentiation
T1168 148-149 -COMMA- denotes ,
T1169 150-159 NN denotes migration
T1170 160-163 CC denotes and
T1171 164-173 NN denotes apoptosis
T1172 174-175 -LRB- denotes [
T1173 175-176 CD denotes 1
T1174 176-177 -RRB- denotes ]
T1175 179-184 DT denotes These
T1176 185-194 NN denotes cytokines
T1177 195-198 MD denotes can
T1178 199-201 VB denotes be
T1179 202-209 VB denotes divided
T1180 210-214 IN denotes into
T1181 215-220 CD denotes three
T1182 221-230 NN denotes subgroups
T1183 230-231 -COLON- denotes :
T1184 232-237 NN denotes TGF-β
T1185 237-238 -COMMA- denotes ,
T1186 239-242 DT denotes the
T1187 243-260 NN denotes activins/inhibins
T1188 260-261 -COMMA- denotes ,
T1189 262-265 CC denotes and
T1190 266-269 DT denotes the
T1191 270-274 NN denotes bone
T1192 275-288 JJ denotes morphogenetic
R859 T1158 T1151 arg1Of superfamily,transforming
R860 T1158 T1154 arg1Of superfamily,β
R861 T1159 T1162 arg1Of play,in
R862 T1161 T1159 arg2Of roles,play
R863 T1161 T1160 arg1Of roles,central
R864 T1163 T1162 arg2Of controlling,in
R865 T1165 T1164 arg1Of proliferation,cellular
R866 T1165 T1166 arg1Of proliferation,","
R867 T1166 T1168 arg1Of ",",","
R868 T1167 T1166 arg2Of differentiation,","
R869 T1168 T1170 arg1Of ",",and
R870 T1169 T1168 arg2Of migration,","
R871 T1170 T1163 arg2Of and,controlling
R872 T1171 T1170 arg2Of apoptosis,and
R873 T1171 T1172 arg1Of apoptosis,[
R874 T1173 T1172 arg2Of 1,[
R875 T1174 T1172 arg3Of ],[
R876 T1176 T1175 arg1Of cytokines,These
R877 T1176 T1177 arg1Of cytokines,can
R878 T1176 T1178 arg1Of cytokines,be
R879 T1176 T1179 arg2Of cytokines,divided
R880 T1179 T1177 arg2Of divided,can
R881 T1179 T1178 arg2Of divided,be
R882 T1179 T1180 arg1Of divided,into
R883 T1182 T1180 arg2Of subgroups,into
R884 T1182 T1181 arg1Of subgroups,three
R885 T1182 T1183 arg1Of subgroups,:
R886 T1184 T1185 arg1Of TGF-β,","
R887 T1184 T1189 arg1Of TGF-β,and
R888 T1187 T1185 arg2Of activins/inhibins,","
R889 T1187 T1186 arg1Of activins/inhibins,the
R890 T1189 T1183 arg2Of and,:
R891 T1189 T1188 arg1Of and,","
R892 T1193 T1189 arg2Of proteins,and
R893 T1193 T1190 arg1Of proteins,the
R894 T1193 T1191 arg1Of proteins,bone
R895 T1193 T1192 arg1Of proteins,morphogenetic
R896 T1193 T1194 arg1Of proteins,(
R897 T1193 T1197 arg1Of proteins,","
R898 T1193 T1198 arg2Of proteins,of
R899 T1193 T1199 arg1Of proteins,which
R900 T1195 T1194 arg2Of BMPs,(
R901 T1196 T1194 arg3Of ),(
R902 T1201 T1200 arg1Of latter,the
R903 T1201 T1202 arg1Of latter,constitute
R904 T1202 T1198 arg1Of constitute,of
R905 T1205 T1202 arg2Of family,constitute
R906 T1205 T1203 arg1Of family,the
R907 T1205 T1204 arg1Of family,largest
R908 T1206 T1207 arg1Of BMPs,are
R909 T1208 T1209 arg1Of 30–38,kDa
R910 T1208 T1210 arg1Of 30–38,hetero-
R911 T1208 T1211 arg1Of 30–38,or
R912 T1212 T1211 arg2Of homodimeric,or
R913 T1213 T1207 arg2Of proteins,are
R914 T1213 T1208 arg1Of proteins,30–38
R915 T1213 T1212 arg1Of proteins,homodimeric
R916 T1213 T1215 arg2Of proteins,identified
R917 T1215 T1214 arg1Of identified,originally
R918 T1218 T1215 arg1Of ability,identified
R919 T1218 T1216 arg2Of ability,by
R920 T1218 T1217 arg1Of ability,their
R921 T1218 T1219 modOf ability,to
R922 T1220 T1219 arg1Of induce,to
R923 T1220 T1226 arg1Of induce,[
R924 T1222 T1221 arg1Of cartilage,ectopic
R925 T1222 T1223 arg1Of cartilage,and
R926 T1223 T1220 arg2Of and,induce
R927 T1225 T1223 arg2Of formation,and
R928 T1225 T1224 arg1Of formation,bone
R929 T1227 T1226 arg2Of "2,3",[
R930 T1228 T1226 arg3Of ],[
R931 T1230 T1229 arg1Of studies,Several
R932 T1230 T1231 arg1Of studies,have
R933 T1230 T1232 arg1Of studies,demonstrated
R934 T1232 T1231 arg2Of demonstrated,have
R935 T1232 T1244 arg1Of demonstrated,recently
R936 T1232 T1245 arg1Of demonstrated,","
R937 T1232 T1247 arg1Of demonstrated,in
R938 T1235 T1232 arg2Of role,demonstrated
R939 T1235 T1233 arg1Of role,an
R940 T1235 T1234 arg1Of role,essential
R941 T1235 T1236 arg1Of role,of
R942 T1235 T1239 arg1Of role,during
R943 T1235 T1242 arg1Of role,and
R944 T1238 T1236 arg2Of proteins,of
R945 T1238 T1237 arg1Of proteins,these
R946 T1240 T1239 arg2Of embryogenesis,during
R947 T1242 T1241 arg1Of and,","
R948 T1244 T1243 arg1Of recently,more
R949 T1247 T1246 arg1Of in,also
R950 T1249 T1247 arg2Of tissues,in
R951 T1249 T1248 arg1Of tissues,adult
R952 T1249 T1250 arg1Of tissues,[
R953 T1251 T1250 arg2Of 1,[
R954 T1252 T1250 arg3Of ],[
R955 T1253 T1254 arg1Of TGF-β,has
R956 T1253 T1255 arg1Of TGF-β,been
R957 T1253 T1257 arg2Of TGF-β,studied
R958 T1253 T1265 arg1Of TGF-β,is
R959 T1257 T1254 arg2Of studied,has
R960 T1257 T1255 arg2Of studied,been
R961 T1257 T1256 arg1Of studied,intensively
R962 T1257 T1258 arg1Of studied,in
R963 T1257 T1264 arg1Of studied,and
R964 T1259 T1260 arg1Of normal,and
R965 T1261 T1260 arg2Of malignant,and
R966 T1263 T1258 arg2Of cells,in
R967 T1263 T1259 arg1Of cells,normal
R968 T1263 T1261 arg1Of cells,malignant
R969 T1263 T1262 arg1Of cells,haematopoietic
R970 T1265 T1264 arg2Of is,and
R971 T1266 T1265 arg2Of one,is
R972 T1266 T1267 arg1Of one,of
R973 T1271 T1269 arg1Of endogenous,most
R974 T1271 T1270 arg1Of endogenous,potent
R975 T1273 T1267 arg2Of regulators,of
R976 T1273 T1268 arg1Of regulators,the
R977 T1273 T1271 arg1Of regulators,endogenous
R978 T1273 T1272 arg1Of regulators,negative
R979 T1273 T1274 arg2Of regulators,known
R980 T1274 T1275 arg1Of known,to
R981 T1276 T1275 arg2Of date.,to
R982 T1276 T1277 arg1Of date.,[
R983 T1278 T1277 arg2Of 4,[
R984 T1279 T1277 arg3Of ],[
R985 T1281 T1280 arg2Of contrast,In
R986 T1284 T1283 arg1Of effect,the
R987 T1284 T1285 arg1Of effect,of
R988 T1284 T1287 arg1Of effect,in
R989 T1284 T1291 arg1Of effect,has
R990 T1284 T1293 arg1Of effect,been
R991 T1284 T1295 arg2Of effect,investigated
R992 T1286 T1285 arg2Of BMPs,of
R993 T1290 T1287 arg2Of system,in
R994 T1290 T1288 arg1Of system,the
R995 T1290 T1289 arg1Of system,immune
R996 T1295 T1280 arg1Of investigated,In
R997 T1295 T1282 arg1Of investigated,","
R998 T1295 T1291 arg2Of investigated,has
R999 T1295 T1292 arg1Of investigated,not
R1000 T1295 T1293 arg2Of investigated,been
R1001 T1295 T1294 arg1Of investigated,widely
R1002 T1298 T1296 arg2Of respect,In
R1003 T1298 T1297 arg1Of respect,that
R1004 T1300 T1301 arg1Of BMP-,2
R1005 T1300 T1302 arg1Of BMP-,","
R1006 T1302 T1304 arg1Of ",",and
R1007 T1303 T1302 arg2Of -4,","
R1008 T1304 T1306 arg1Of and,have
R1009 T1304 T1307 arg1Of and,been
R1010 T1304 T1308 arg2Of and,found
R1011 T1304 T1310 arg1Of and,control
R1012 T1305 T1304 arg2Of -7,and
R1013 T1308 T1296 arg1Of found,In
R1014 T1308 T1299 arg1Of found,","
R1015 T1308 T1306 arg2Of found,have
R1016 T1308 T1307 arg2Of found,been
R1017 T1310 T1308 arg3Of control,found
R1018 T1310 T1309 arg1Of control,to
R1019 T1311 T1312 arg1Of differentiation,of
R1020 T1311 T1319 arg1Of differentiation,and
R1021 T1315 T1312 arg2Of cells,of
R1022 T1315 T1313 arg1Of cells,hematopoietic
R1023 T1315 T1314 arg1Of cells,stem
R1024 T1315 T1316 arg1Of cells,[
R1025 T1317 T1316 arg2Of 5,[
R1026 T1318 T1316 arg3Of ],[
R1027 T1319 T1310 arg2Of and,control
R1028 T1323 T1319 arg2Of development,and
R1029 T1323 T1320 arg1Of development,early
R1030 T1323 T1321 arg1Of development,T
R1031 T1323 T1322 arg1Of development,cell
R1032 T1323 T1324 arg1Of development,[
R1033 T1325 T1324 arg2Of "6,7",[
R1034 T1326 T1324 arg3Of ],[
R1035 T1327 T1328 arg1Of BMP-6,has
R1036 T1327 T1329 arg1Of BMP-6,been
R1037 T1327 T1330 arg2Of BMP-6,reported
R1038 T1327 T1332 arg1Of BMP-6,reduce
R1039 T1330 T1328 arg2Of reported,has
R1040 T1330 T1329 arg2Of reported,been
R1041 T1332 T1330 arg3Of reduce,reported
R1042 T1332 T1331 arg1Of reduce,to
R1043 T1334 T1332 arg2Of number,reduce
R1044 T1334 T1333 arg1Of number,the
R1045 T1334 T1335 arg1Of number,of
R1046 T1337 T1335 arg2Of cells,of
R1047 T1337 T1336 arg1Of cells,cobblestone-area-forming
R1048 T1337 T1338 arg1Of cells,of
R1049 T1342 T1338 arg2Of cells,of
R1050 T1342 T1339 arg1Of cells,normal
R1051 T1342 T1340 arg1Of cells,human
R1052 T1342 T1341 arg1Of cells,haematopoietic
R1053 T1342 T1343 arg1Of cells,[
R1054 T1344 T1343 arg2Of 8,[
R1055 T1345 T1343 arg3Of ],[
R1056 T1348 T1349 arg1Of BMP-2,","
R1057 T1349 T1351 arg1Of ",",","
R1058 T1350 T1349 arg2Of -4,","
R1059 T1351 T1353 arg1Of ",",and
R1060 T1352 T1351 arg2Of 6,","
R1061 T1353 T1355 arg1Of and,had
R1062 T1354 T1353 arg2Of -7,and
R1063 T1355 T1346 arg1Of had,Furthermore
R1064 T1355 T1347 arg1Of had,","
R1065 T1355 T1362 arg1Of had,on
R1066 T1357 T1358 arg1Of antiproliferative,and
R1067 T1360 T1358 arg2Of proapoptotic,and
R1068 T1360 T1359 arg1Of proapoptotic,a
R1069 T1361 T1355 arg2Of effect,had
R1070 T1361 T1356 arg1Of effect,an
R1071 T1361 T1357 arg1Of effect,antiproliferative
R1072 T1361 T1360 arg1Of effect,proapoptotic
R1073 T1365 T1362 arg2Of cells,on
R1074 T1365 T1363 arg1Of cells,multiple
R1075 T1365 T1364 arg1Of cells,myeloma
R1076 T1365 T1366 arg1Of cells,[
R1077 T1367 T1366 arg2Of 9-11,[
R1078 T1368 T1366 arg3Of ],[
R1079 T1370 T1369 arg2Of addition,In
R1080 T1375 T1372 arg2Of profiling,by
R1081 T1375 T1373 arg1Of profiling,gene
R1082 T1375 T1374 arg1Of profiling,expression
R1083 T1377 T1379 arg1Of BMP-6,increased
R1084 T1377 T1389 arg1Of BMP-6,was
R1085 T1377 T1390 arg2Of BMP-6,associated
R1086 T1379 T1388 arg1Of increased,and
R1087 T1382 T1379 arg2Of value,increased
R1088 T1382 T1380 arg1Of value,the
R1089 T1382 T1381 arg1Of value,predictive
R1090 T1382 T1383 arg1Of value,for
R1091 T1387 T1383 arg2Of test,for
R1092 T1387 T1384 arg1Of test,a
R1093 T1387 T1385 arg1Of test,multi-gene
R1094 T1387 T1386 arg1Of test,signature
R1095 T1388 T1369 arg1Of and,In
R1096 T1388 T1371 arg1Of and,","
R1097 T1388 T1372 arg1Of and,by
R1098 T1388 T1376 arg1Of and,","
R1099 T1388 T1378 arg1Of and,significantly
R1100 T1390 T1388 arg2Of associated,and
R1101 T1390 T1389 arg2Of associated,was
R1102 T1390 T1391 arg1Of associated,with
R1103 T1390 T1404 arg1Of associated,[
R1104 T1394 T1391 arg2Of outcome,with
R1105 T1394 T1392 arg1Of outcome,a
R1106 T1394 T1393 arg1Of outcome,poor
R1107 T1394 T1395 arg1Of outcome,in
R1108 T1400 T1395 arg2Of lymphomas,in
R1109 T1400 T1396 arg1Of lymphomas,diffuse
R1110 T1400 T1397 arg1Of lymphomas,large
R1111 T1400 T1398 arg1Of lymphomas,B
R1112 T1400 T1399 arg1Of lymphomas,cell
R1113 T1400 T1401 arg1Of lymphomas,(
R1114 T1402 T1401 arg2Of DLBCL,(
R1115 T1403 T1401 arg3Of ),(
R1116 T1405 T1404 arg2Of 12,[
R1117 T1406 T1404 arg3Of ],[
R1118 T1407 T1408 arg1Of BMP-6,","
R1119 T1407 T1409 arg1Of BMP-6,like
R1120 T1407 T1414 arg1Of BMP-6,","
R1121 T1413 T1409 arg2Of members,like
R1122 T1413 T1410 arg1Of members,the
R1123 T1413 T1411 arg1Of members,other
R1124 T1413 T1412 arg1Of members,BMP
R1125 T1414 T1416 arg1Of ",",through
R1126 T1414 T1424 arg1Of ",",[
R1127 T1414 T1430 arg1Of ",",and
R1128 T1415 T1414 arg2Of signals,","
R1129 T1417 T1418 arg1Of ligation,and
R1130 T1418 T1416 arg2Of and,through
R1131 T1418 T1420 arg1Of and,of
R1132 T1419 T1418 arg2Of heterodimerzation,and
R1133 T1422 T1420 arg2Of type,of
R1134 T1422 T1421 arg1Of type,BMP
R1135 T1422 T1423 arg1Of type,I
R1136 T1425 T1424 arg2Of activin-like-kinase,[
R1137 T1425 T1426 arg1Of activin-like-kinase,(
R1138 T1427 T1426 arg2Of ALK,(
R1139 T1428 T1426 arg3Of ),(
R1140 T1429 T1424 arg3Of ],[
R1141 T1430 T1436 arg1Of and,","
R1142 T1430 T1437 arg1Of and,which
R1143 T1430 T1439 arg1Of and,propagates
R1144 T1435 T1430 arg2Of receptors,and
R1145 T1435 T1431 arg1Of receptors,type
R1146 T1435 T1432 arg1Of receptors,II
R1147 T1435 T1433 arg1Of receptors,serine-threonine
R1148 T1435 T1434 arg1Of receptors,kinase
R1149 T1439 T1438 arg1Of propagates,subsequently
R1150 T1439 T1442 arg1Of propagates,downstream
R1151 T1439 T1443 arg1Of propagates,by
R1152 T1441 T1439 arg2Of signal,propagates
R1153 T1441 T1440 arg1Of signal,the
R1154 T1444 T1443 arg2Of phosphorylating,by
R1155 T1446 T1444 arg2Of proteins,phosphorylating
R1156 T1446 T1445 arg1Of proteins,Smad
R1157 T1447 T1448 arg1Of BMP-6,can
R1158 T1447 T1449 arg1Of BMP-6,signal
R1159 T1449 T1448 arg2Of signal,can
R1160 T1449 T1450 arg1Of signal,through
R1161 T1452 T1450 arg2Of ligation,through
R1162 T1452 T1451 arg1Of ligation,the
R1163 T1452 T1453 arg1Of ligation,of
R1164 T1452 T1474 arg1Of ligation,","
R1165 T1452 T1475 arg1Of ligation,which
R1166 T1452 T1476 arg1Of ligation,lead
R1167 T1457 T1455 arg1Of receptors,type
R1168 T1457 T1456 arg1Of receptors,I
R1169 T1458 T1459 arg1Of Act-RIA,","
R1170 T1459 T1457 arg1Of ",",receptors
R1171 T1459 T1462 arg1Of ",",and
R1172 T1460 T1459 arg2Of BMP-RIA,","
R1173 T1462 T1454 arg1Of and,the
R1174 T1462 T1461 arg1Of and,","
R1175 T1462 T1464 arg1Of and,and
R1176 T1463 T1462 arg2Of BMP-RIB,and
R1177 T1464 T1453 arg2Of and,of
R1178 T1468 T1466 arg1Of receptors,type
R1179 T1468 T1467 arg1Of receptors,II
R1180 T1469 T1470 arg1Of BMP-RII,","
R1181 T1470 T1472 arg1Of ",",and
R1182 T1471 T1470 arg2Of Act-RIIA,","
R1183 T1472 T1464 arg2Of and,and
R1184 T1472 T1465 arg1Of and,the
R1185 T1472 T1468 arg1Of and,receptors
R1186 T1473 T1472 arg2Of Act-RIIB,and
R1187 T1476 T1477 arg1Of lead,to
R1188 T1479 T1477 arg2Of phosphorylation,to
R1189 T1479 T1478 arg1Of phosphorylation,the
R1190 T1479 T1480 arg1Of phosphorylation,of
R1191 T1483 T1480 arg2Of Smads,of
R1192 T1483 T1481 arg1Of Smads,the
R1193 T1483 T1482 arg1Of Smads,receptor
R1194 T1483 T1484 arg1Of Smads,(
R1195 T1485 T1486 arg1Of Smad-1,","
R1196 T1486 T1489 arg1Of ",",and
R1197 T1487 T1486 arg2Of Smad-5,","
R1198 T1489 T1484 arg2Of and,(
R1199 T1489 T1488 arg1Of and,","
R1200 T1490 T1489 arg2Of Smad-8,and
R1201 T1491 T1484 arg3Of ),(
R1202 T1494 T1492 arg1Of Smads,The
R1203 T1494 T1493 arg1Of Smads,R-
R1204 T1494 T1496 arg1Of Smads,form
R1205 T1494 T1505 arg1Of Smads,are
R1206 T1494 T1506 arg2Of Smads,translocated
R1207 T1496 T1498 arg1Of form,with
R1208 T1496 T1504 arg1Of form,and
R1209 T1497 T1496 arg2Of complexes,form
R1210 T1500 T1498 arg2Of co-Smad,with
R1211 T1500 T1499 arg1Of co-Smad,the
R1212 T1500 T1501 arg1Of co-Smad,(
R1213 T1502 T1501 arg2Of Smad4,(
R1214 T1503 T1501 arg3Of ),(
R1215 T1504 T1495 arg1Of and,then
R1216 T1506 T1504 arg2Of translocated,and
R1217 T1506 T1505 arg2Of translocated,are
R1218 T1506 T1507 arg1Of translocated,into
R1219 T1509 T1507 arg2Of nucleus,into
R1220 T1509 T1508 arg1Of nucleus,the
R1221 T1509 T1510 arg1Of nucleus,where
R1222 T1511 T1512 arg1Of they,exert
R1223 T1512 T1510 arg2Of exert,where
R1224 T1512 T1515 arg1Of exert,[
R1225 T1514 T1512 arg2Of regulation,exert
R1226 T1514 T1513 arg1Of regulation,gene
R1227 T1516 T1515 arg2Of "1,13",[
R1228 T1517 T1515 arg3Of ],[
R1229 T1521 T1518 arg2Of role,Given
R1230 T1521 T1519 arg1Of role,the
R1231 T1521 T1520 arg2Of role,reported
R1232 T1521 T1522 arg1Of role,of
R1233 T1521 T1524 arg1Of role,in
R1234 T1523 T1522 arg2Of BMP-6,of
R1235 T1526 T1525 arg1Of malignancies,B-cell
R1236 T1526 T1527 arg1Of malignancies,and
R1237 T1527 T1524 arg2Of and,in
R1238 T1530 T1527 arg2Of cells,and
R1239 T1530 T1528 arg1Of cells,haematopoietic
R1240 T1530 T1529 arg1Of cells,progenitor
R1241 T1532 T1533 arg1Of we,wanted
R1242 T1532 T1535 arg1Of we,explore
R1243 T1533 T1518 arg1Of wanted,Given
R1244 T1533 T1531 arg1Of wanted,","
R1245 T1535 T1533 arg2Of explore,wanted
R1246 T1535 T1534 arg1Of explore,to
R1247 T1535 T1539 arg1Of explore,in
R1248 T1538 T1535 arg2Of role,explore
R1249 T1538 T1536 arg1Of role,its
R1250 T1538 T1537 arg1Of role,potential
R1251 T1543 T1539 arg2Of cells,in
R1252 T1543 T1540 arg1Of cells,normal
R1253 T1543 T1541 arg1Of cells,human
R1254 T1543 T1542 arg1Of cells,B
R1255 T1544 T1545 arg1Of We,studied
R1256 T1547 T1545 arg2Of effects,studied
R1257 T1547 T1546 arg1Of effects,the
R1258 T1547 T1548 arg1Of effects,of
R1259 T1547 T1550 arg1Of effects,on
R1260 T1549 T1548 arg2Of BMP-6,of
R1261 T1551 T1552 arg1Of proliferation,and
R1262 T1552 T1550 arg2Of and,on
R1263 T1552 T1554 arg1Of and,on
R1264 T1553 T1552 arg2Of apoptosis,and
R1265 T1559 T1554 arg2Of cells,on
R1266 T1559 T1555 arg1Of cells,resting
R1267 T1559 T1556 arg1Of cells,and
R1268 T1559 T1557 arg2Of cells,stimulated
R1269 T1559 T1558 arg1Of cells,B
R1270 T1563 T1562 arg1Of expression,the
R1271 T1563 T1564 arg1Of expression,of
R1272 T1563 T1569 arg1Of expression,induced
R1273 T1563 T1585 arg1Of expression,were
R1274 T1563 T1586 arg2Of expression,resolved
R1275 T1566 T1565 arg1Of receptors,BMP
R1276 T1566 T1567 arg1Of receptors,and
R1277 T1567 T1564 arg2Of and,of
R1278 T1568 T1567 arg2Of BMP-6,and
R1279 T1569 T1576 arg1Of induced,with
R1280 T1569 T1584 arg1Of induced,","
R1281 T1570 T1569 arg2Of activation,induced
R1282 T1570 T1571 arg1Of activation,of
R1283 T1575 T1571 arg2Of pathway,of
R1284 T1575 T1572 arg1Of pathway,the
R1285 T1575 T1573 arg1Of pathway,Smad
R1286 T1575 T1574 arg1Of pathway,signalling
R1287 T1578 T1576 arg2Of regulation,with
R1288 T1578 T1577 arg1Of regulation,subsequent
R1289 T1578 T1579 arg1Of regulation,of
R1290 T1583 T1579 arg2Of Id1–Id4,of
R1291 T1583 T1580 arg1Of Id1–Id4,the
R1292 T1583 T1581 arg1Of Id1–Id4,target
R1293 T1583 T1582 arg1Of Id1–Id4,genes
R1294 T1584 T1560 arg1Of ",",Furthermore
R1295 T1584 T1561 arg1Of ",",","
R1296 T1586 T1584 arg2Of resolved,","
R1297 T1586 T1585 arg2Of resolved,were
R1298 T1589 T1590 arg1Of we,investigated
R1299 T1590 T1587 arg1Of investigated,Finally
R1300 T1590 T1588 arg1Of investigated,","
R1301 T1593 T1592 arg1Of cells,B
R1302 T1593 T1595 arg1Of cells,were
R1303 T1593 T1596 arg1Of cells,capable
R1304 T1593 T1598 arg1Of cells,producing
R1305 T1595 T1590 arg2Of were,investigated
R1306 T1595 T1591 arg1Of were,whether
R1307 T1595 T1594 arg1Of were,also
R1308 T1596 T1595 arg2Of capable,were
R1309 T1596 T1597 arg1Of capable,of
R1310 T1598 T1597 arg2Of producing,of
R1311 T1599 T1598 arg2Of BMP-6,producing
R849 T1148 T1149 arg1Of Members,of
R850 T1148 T1159 arg1Of Members,play
R851 T1148 T1163 arg1Of Members,controlling
R852 T1154 T1152 arg1Of β,growth
R853 T1154 T1153 arg1Of β,factor
R854 T1154 T1155 arg1Of β,(
R855 T1156 T1155 arg2Of TGF-β,(
R856 T1157 T1155 arg3Of ),(
R857 T1158 T1149 arg2Of superfamily,of
R858 T1158 T1150 arg1Of superfamily,the

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1600 1929-1947 Anaphor denotes the receptor Smads
T1601 1949-1955 Antecedent denotes Smad-1
T1602 1957-1963 Antecedent denotes Smad-5
T1603 1969-1975 Antecedent denotes Smad-8
T1604 1978-1990 Anaphor denotes The R- Smads
T1605 2506-2522 Anaphor denotes the target genes
T1606 2523-2526 Antecedent denotes Id1
T1607 2527-2530 Antecedent denotes Id4
R1312 T1600 T1601 boundBy the receptor Smads,Smad-1
R1313 T1600 T1602 boundBy the receptor Smads,Smad-5
R1314 T1600 T1603 boundBy the receptor Smads,Smad-8
R1315 T1604 T1601 boundBy The R- Smads,Smad-1
R1316 T1604 T1602 boundBy The R- Smads,Smad-5
R1317 T1604 T1603 boundBy The R- Smads,Smad-8
R1318 T1605 T1606 boundBy the target genes,Id1
R1319 T1605 T1607 boundBy the target genes,Id4

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1730 11-18 NNS denotes Members
T1731 19-21 IN denotes of
T1732 22-25 DT denotes the
T1733 26-38 VBG denotes transforming
T1734 39-45 NN denotes growth
T1735 46-52 NN denotes factor
T1736 53-54 NN denotes β
T1737 55-56 -LRB- denotes (
T1738 56-61 NNP denotes TGF-β
T1739 61-62 -RRB- denotes )
T1740 63-74 RB denotes superfamily
T1741 75-79 VB denotes play
T1742 80-87 JJ denotes central
T1743 88-93 NNS denotes roles
T1744 94-96 IN denotes in
T1745 97-108 VBG denotes controlling
T1746 109-117 JJ denotes cellular
T1747 118-131 NN denotes proliferation
T1748 131-132 , denotes ,
T1749 133-148 NN denotes differentiation
T1750 148-149 , denotes ,
T1751 150-159 NN denotes migration
T1752 160-163 CC denotes and
T1753 164-173 NN denotes apoptosis
T1754 174-175 NN denotes [
T1755 175-176 CD denotes 1
T1756 176-177 NNP denotes ]
T1757 177-178 . denotes .
T1758 179-184 DT denotes These
T1759 185-194 NNS denotes cytokines
T1760 195-198 MD denotes can
T1761 199-201 VB denotes be
T1762 202-209 VBN denotes divided
T1763 210-214 IN denotes into
T1764 215-220 CD denotes three
T1765 221-230 NNS denotes subgroups
T1766 230-231 : denotes :
T1767 232-237 JJ denotes TGF-β
T1768 237-238 , denotes ,
T1769 239-242 DT denotes the
T1770 243-260 NNS denotes activins/inhibins
T1771 260-261 , denotes ,
T1772 262-265 CC denotes and
T1773 266-269 DT denotes the
T1774 270-274 NN denotes bone
T1775 275-288 JJ denotes morphogenetic
T1776 289-297 NNS denotes proteins
T1777 298-299 -LRB- denotes (
T1778 299-303 NNS denotes BMPs
T1779 303-304 -RRB- denotes )
T1780 304-305 , denotes ,
T1781 306-308 IN denotes of
T1782 309-314 WDT denotes which
T1783 315-318 DT denotes the
T1784 319-325 JJ denotes latter
T1785 326-336 VBP denotes constitute
T1786 337-340 DT denotes the
T1787 341-348 JJS denotes largest
T1788 349-355 NN denotes family
T1789 355-356 . denotes .
T1790 357-361 NNS denotes BMPs
T1791 362-365 VBP denotes are
T1792 366-368 CD denotes 30
T1793 369-371 CD denotes 38
T1794 372-375 NN denotes kDa
T1795 376-382 NN denotes hetero
T1796 382-383 : denotes -
T1797 384-386 CC denotes or
T1798 387-398 JJ denotes homodimeric
T1799 399-407 NNS denotes proteins
T1800 408-418 RB denotes originally
T1801 419-429 VBN denotes identified
T1802 430-432 IN denotes by
T1803 433-438 PRP$ denotes their
T1804 439-446 NN denotes ability
T1805 447-449 TO denotes to
T1806 450-456 VB denotes induce
T1807 457-464 JJ denotes ectopic
T1808 465-474 NN denotes cartilage
T1809 475-478 CC denotes and
T1810 479-483 NN denotes bone
T1811 484-493 NN denotes formation
T1812 494-495 NNP denotes [
T1813 495-498 CD denotes 2,3
T1814 498-499 NNP denotes ]
T1815 499-500 . denotes .
T1816 501-508 JJ denotes Several
T1817 509-516 NNS denotes studies
T1818 517-521 VBP denotes have
T1819 522-534 VBN denotes demonstrated
T1820 535-537 DT denotes an
T1821 538-547 JJ denotes essential
T1822 548-552 NN denotes role
T1823 553-555 IN denotes of
T1824 556-561 DT denotes these
T1825 562-570 NNS denotes proteins
T1826 571-577 IN denotes during
T1827 578-591 NN denotes embryogenesis
T1828 591-592 , denotes ,
T1829 593-596 CC denotes and
T1830 597-601 RBR denotes more
T1831 602-610 RB denotes recently
T1832 610-611 , denotes ,
T1833 612-616 RB denotes also
T1834 617-619 IN denotes in
T1835 620-625 NN denotes adult
T1836 626-633 NNS denotes tissues
T1837 634-635 VBP denotes [
T1838 635-636 CD denotes 1
T1839 636-637 NNP denotes ]
T1840 637-638 . denotes .
T1841 639-644 NNP denotes TGF-β
T1842 645-648 VBZ denotes has
T1843 649-653 VBN denotes been
T1844 654-665 RB denotes intensively
T1845 666-673 VBN denotes studied
T1846 674-676 IN denotes in
T1847 677-683 JJ denotes normal
T1848 684-687 CC denotes and
T1849 688-697 JJ denotes malignant
T1850 698-712 JJ denotes haematopoietic
T1851 713-718 NNS denotes cells
T1852 719-722 CC denotes and
T1853 723-725 VBZ denotes is
T1854 726-729 CD denotes one
T1855 730-732 IN denotes of
T1856 733-736 DT denotes the
T1857 737-741 RBS denotes most
T1858 742-748 JJ denotes potent
T1859 749-759 JJ denotes endogenous
T1860 760-768 JJ denotes negative
T1861 769-779 NNS denotes regulators
T1862 780-785 VBN denotes known
T1863 786-788 TO denotes to
T1864 789-793 NN denotes date
T1865 793-794 . denotes .
T1866 795-796 NN denotes [
T1867 796-797 CD denotes 4
T1868 797-798 NNP denotes ]
T1869 798-799 . denotes .
T1870 800-802 IN denotes In
T1871 803-811 NN denotes contrast
T1872 811-812 , denotes ,
T1873 813-816 DT denotes the
T1874 817-823 NN denotes effect
T1875 824-826 IN denotes of
T1876 827-831 NNS denotes BMPs
T1877 832-834 IN denotes in
T1878 835-838 DT denotes the
T1879 839-845 JJ denotes immune
T1880 846-852 NN denotes system
T1881 853-856 VBZ denotes has
T1882 857-860 RB denotes not
T1883 861-865 VBN denotes been
T1884 866-872 RB denotes widely
T1885 873-885 VBN denotes investigated
T1886 885-886 . denotes .
T1887 887-889 IN denotes In
T1888 890-894 DT denotes that
T1889 895-902 NN denotes respect
T1890 902-903 , denotes ,
T1891 904-907 NN denotes BMP
T1892 907-908 : denotes -
T1893 909-910 CD denotes 2
T1894 910-911 , denotes ,
T1895 912-914 CD denotes -4
T1896 915-918 CC denotes and
T1897 919-921 CD denotes -7
T1898 922-926 VBP denotes have
T1899 927-931 VBN denotes been
T1900 932-937 VBN denotes found
T1901 938-940 TO denotes to
T1902 941-948 VB denotes control
T1903 949-964 NN denotes differentiation
T1904 965-967 IN denotes of
T1905 968-981 JJ denotes hematopoietic
T1906 982-986 NN denotes stem
T1907 987-992 NNS denotes cells
T1908 993-994 VBP denotes [
T1909 994-995 CD denotes 5
T1910 995-996 NNP denotes ]
T1911 997-1000 CC denotes and
T1912 1001-1006 JJ denotes early
T1913 1007-1008 NN denotes T
T1914 1009-1013 NN denotes cell
T1915 1014-1025 NN denotes development
T1916 1026-1027 NNP denotes [
T1917 1027-1030 CD denotes 6,7
T1918 1030-1031 NNP denotes ]
T1919 1031-1032 . denotes .
T1920 1033-1038 NN denotes BMP-6
T1921 1039-1042 VBZ denotes has
T1922 1043-1047 VBN denotes been
T1923 1048-1056 VBN denotes reported
T1924 1057-1059 TO denotes to
T1925 1060-1066 VB denotes reduce
T1926 1067-1070 DT denotes the
T1927 1071-1077 NN denotes number
T1928 1078-1080 IN denotes of
T1929 1081-1105 JJ denotes cobblestone-area-forming
T1930 1106-1111 NNS denotes cells
T1931 1112-1114 IN denotes of
T1932 1115-1121 JJ denotes normal
T1933 1122-1127 JJ denotes human
T1934 1128-1142 JJ denotes haematopoietic
T1935 1143-1148 NNS denotes cells
T1936 1149-1150 VBP denotes [
T1937 1150-1151 CD denotes 8
T1938 1151-1152 NNP denotes ]
T1939 1152-1153 . denotes .
T1940 1154-1165 RB denotes Furthermore
T1941 1165-1166 , denotes ,
T1942 1167-1172 NNP denotes BMP-2
T1943 1172-1173 , denotes ,
T1944 1174-1176 CD denotes -4
T1945 1176-1177 , denotes ,
T1946 1178-1179 CD denotes 6
T1947 1180-1183 CC denotes and
T1948 1184-1186 CD denotes -7
T1949 1187-1190 VBD denotes had
T1950 1191-1193 DT denotes an
T1951 1194-1211 JJ denotes antiproliferative
T1952 1212-1215 CC denotes and
T1953 1216-1217 DT denotes a
T1954 1218-1230 JJ denotes proapoptotic
T1955 1231-1237 NN denotes effect
T1956 1238-1240 IN denotes on
T1957 1241-1249 JJ denotes multiple
T1958 1250-1257 NN denotes myeloma
T1959 1258-1263 NNS denotes cells
T1960 1264-1265 NNP denotes [
T1961 1265-1269 CD denotes 9-11
T1962 1269-1270 NNP denotes ]
T1963 1270-1271 . denotes .
T1964 1272-1274 IN denotes In
T1965 1275-1283 NN denotes addition
T1966 1283-1284 , denotes ,
T1967 1285-1287 IN denotes by
T1968 1288-1292 NN denotes gene
T1969 1293-1303 NN denotes expression
T1970 1304-1313 NN denotes profiling
T1971 1313-1314 , denotes ,
T1972 1315-1320 NNP denotes BMP-6
T1973 1321-1334 RB denotes significantly
T1974 1335-1344 VBD denotes increased
T1975 1345-1348 DT denotes the
T1976 1349-1359 JJ denotes predictive
T1977 1360-1365 NN denotes value
T1978 1366-1369 IN denotes for
T1979 1370-1371 DT denotes a
T1980 1372-1382 JJ denotes multi-gene
T1981 1383-1392 NN denotes signature
T1982 1393-1397 NN denotes test
T1983 1398-1401 CC denotes and
T1984 1402-1405 VBD denotes was
T1985 1406-1416 VBN denotes associated
T1986 1417-1421 IN denotes with
T1987 1422-1423 DT denotes a
T1988 1424-1428 JJ denotes poor
T1989 1429-1436 NN denotes outcome
T1990 1437-1439 IN denotes in
T1991 1440-1447 NN denotes diffuse
T1992 1448-1453 JJ denotes large
T1993 1454-1455 NNP denotes B
T1994 1456-1460 NN denotes cell
T1995 1461-1470 NNS denotes lymphomas
T1996 1471-1472 -LRB- denotes (
T1997 1472-1477 NNP denotes DLBCL
T1998 1477-1478 -RRB- denotes )
T1999 1479-1480 NNP denotes [
T2000 1480-1482 CD denotes 12
T2001 1482-1483 NNP denotes ]
T2002 1483-1484 . denotes .
T2003 1485-1490 NN denotes BMP-6
T2004 1490-1491 , denotes ,
T2005 1492-1496 IN denotes like
T2006 1497-1500 DT denotes the
T2007 1501-1506 JJ denotes other
T2008 1507-1510 NN denotes BMP
T2009 1511-1518 NNS denotes members
T2010 1518-1519 , denotes ,
T2011 1520-1527 NNS denotes signals
T2012 1528-1535 IN denotes through
T2013 1536-1544 NN denotes ligation
T2014 1545-1548 CC denotes and
T2015 1549-1566 NN denotes heterodimerzation
T2016 1567-1569 IN denotes of
T2017 1570-1573 NN denotes BMP
T2018 1574-1578 NN denotes type
T2019 1579-1580 PRP denotes I
T2020 1581-1582 VBP denotes [
T2021 1582-1601 NN denotes activin-like-kinase
T2022 1602-1603 -LRB- denotes (
T2023 1603-1606 NNP denotes ALK
T2024 1606-1607 -RRB- denotes )
T2025 1607-1608 NNP denotes ]
T2026 1609-1612 CC denotes and
T2027 1613-1617 NN denotes type
T2028 1618-1620 NNP denotes II
T2029 1621-1637 JJ denotes serine-threonine
T2030 1638-1644 NN denotes kinase
T2031 1645-1654 NNS denotes receptors
T2032 1654-1655 , denotes ,
T2033 1656-1661 WDT denotes which
T2034 1662-1674 RB denotes subsequently
T2035 1675-1685 VBZ denotes propagates
T2036 1686-1689 DT denotes the
T2037 1690-1696 NN denotes signal
T2038 1697-1707 JJ denotes downstream
T2039 1708-1710 IN denotes by
T2040 1711-1726 VBG denotes phosphorylating
T2041 1727-1731 NNP denotes Smad
T2042 1732-1740 NNS denotes proteins
T2043 1740-1741 . denotes .
T2044 1742-1747 NN denotes BMP-6
T2045 1748-1751 MD denotes can
T2046 1752-1758 VB denotes signal
T2047 1759-1766 IN denotes through
T2048 1767-1770 DT denotes the
T2049 1771-1779 NN denotes ligation
T2050 1780-1782 IN denotes of
T2051 1783-1786 DT denotes the
T2052 1787-1791 NN denotes type
T2053 1792-1793 PRP denotes I
T2054 1794-1803 NNS denotes receptors
T2055 1804-1811 NNP denotes Act-RIA
T2056 1811-1812 , denotes ,
T2057 1813-1820 NNP denotes BMP-RIA
T2058 1820-1821 , denotes ,
T2059 1822-1825 CC denotes and
T2060 1826-1833 NNP denotes BMP-RIB
T2061 1834-1837 CC denotes and
T2062 1838-1841 DT denotes the
T2063 1842-1846 NN denotes type
T2064 1847-1849 NNP denotes II
T2065 1850-1859 NNS denotes receptors
T2066 1860-1867 NNP denotes BMP-RII
T2067 1867-1868 , denotes ,
T2068 1869-1877 NNP denotes Act-RIIA
T2069 1878-1881 CC denotes and
T2070 1882-1890 NNP denotes Act-RIIB
T2071 1890-1891 , denotes ,
T2072 1892-1897 WDT denotes which
T2073 1898-1902 VBP denotes lead
T2074 1903-1905 TO denotes to
T2075 1906-1909 DT denotes the
T2076 1910-1925 NN denotes phosphorylation
T2077 1926-1928 IN denotes of
T2078 1929-1932 DT denotes the
T2079 1933-1941 NN denotes receptor
T2080 1942-1947 NNS denotes Smads
T2081 1948-1949 -LRB- denotes (
T2082 1949-1955 NNP denotes Smad-1
T2083 1955-1956 , denotes ,
T2084 1957-1963 NNP denotes Smad-5
T2085 1963-1964 , denotes ,
T2086 1965-1968 CC denotes and
T2087 1969-1975 NNP denotes Smad-8
T2088 1975-1976 -RRB- denotes )
T2089 1976-1977 . denotes .
T2090 1978-1981 DT denotes The
T2091 1982-1983 NN denotes R
T2092 1983-1984 : denotes -
T2093 1985-1990 NNS denotes Smads
T2094 1991-1995 RB denotes then
T2095 1996-2000 VBP denotes form
T2096 2001-2010 NNS denotes complexes
T2097 2011-2015 IN denotes with
T2098 2016-2019 DT denotes the
T2099 2020-2027 NNP denotes co-Smad
T2100 2028-2029 -LRB- denotes (
T2101 2029-2034 NNP denotes Smad4
T2102 2034-2035 -RRB- denotes )
T2103 2036-2039 CC denotes and
T2104 2040-2043 VBP denotes are
T2105 2044-2056 VBN denotes translocated
T2106 2057-2061 IN denotes into
T2107 2062-2065 DT denotes the
T2108 2066-2073 NN denotes nucleus
T2109 2074-2079 WRB denotes where
T2110 2080-2084 PRP denotes they
T2111 2085-2090 VBP denotes exert
T2112 2091-2095 NN denotes gene
T2113 2096-2106 NN denotes regulation
T2114 2107-2108 NNP denotes [
T2115 2108-2112 CD denotes 1,13
T2116 2112-2113 NNP denotes ]
T2117 2113-2114 . denotes .
T2118 2115-2120 VBN denotes Given
T2119 2121-2124 DT denotes the
T2120 2125-2133 VBN denotes reported
T2121 2134-2138 NN denotes role
T2122 2139-2141 IN denotes of
T2123 2142-2147 NNP denotes BMP-6
T2124 2148-2150 IN denotes in
T2125 2151-2157 NNP denotes B-cell
T2126 2158-2170 NNS denotes malignancies
T2127 2171-2174 CC denotes and
T2128 2175-2189 JJ denotes haematopoietic
T2129 2190-2200 NN denotes progenitor
T2130 2201-2206 NNS denotes cells
T2131 2206-2207 , denotes ,
T2132 2208-2210 PRP denotes we
T2133 2211-2217 VBD denotes wanted
T2134 2218-2220 TO denotes to
T2135 2221-2228 VB denotes explore
T2136 2229-2232 PRP$ denotes its
T2137 2233-2242 JJ denotes potential
T2138 2243-2247 NN denotes role
T2139 2248-2250 IN denotes in
T2140 2251-2257 JJ denotes normal
T2141 2258-2263 JJ denotes human
T2142 2264-2265 NNP denotes B
T2143 2266-2271 NNS denotes cells
T2144 2271-2272 . denotes .
T2145 2273-2275 PRP denotes We
T2146 2276-2283 VBD denotes studied
T2147 2284-2287 DT denotes the
T2148 2288-2295 NNS denotes effects
T2149 2296-2298 IN denotes of
T2150 2299-2304 NN denotes BMP-6
T2151 2305-2307 IN denotes on
T2152 2308-2321 NN denotes proliferation
T2153 2322-2325 CC denotes and
T2154 2326-2335 NN denotes apoptosis
T2155 2336-2338 IN denotes on
T2156 2339-2346 VBG denotes resting
T2157 2347-2350 CC denotes and
T2158 2351-2361 VBD denotes stimulated
T2159 2362-2363 NNP denotes B
T2160 2364-2369 NNS denotes cells
T2161 2369-2370 . denotes .
T2162 2371-2382 RB denotes Furthermore
T2163 2382-2383 , denotes ,
T2164 2384-2387 DT denotes the
T2165 2388-2398 NN denotes expression
T2166 2399-2401 IN denotes of
T2167 2402-2405 NN denotes BMP
T2168 2406-2415 NNS denotes receptors
T2169 2416-2419 CC denotes and
T2170 2420-2425 NNP denotes BMP-6
T2171 2426-2433 VBD denotes induced
T2172 2434-2444 NN denotes activation
T2173 2445-2447 IN denotes of
T2174 2448-2451 DT denotes the
T2175 2452-2456 NNP denotes Smad
T2176 2457-2467 JJ denotes signalling
T2177 2468-2475 NN denotes pathway
T2178 2476-2480 IN denotes with
T2179 2481-2491 JJ denotes subsequent
T2180 2492-2502 NN denotes regulation
T2181 2503-2505 IN denotes of
T2182 2506-2509 DT denotes the
T2183 2510-2516 NN denotes target
T2184 2517-2522 NNS denotes genes
T2185 2523-2526 VBP denotes Id1
T2186 2527-2530 NNP denotes Id4
T2187 2530-2531 , denotes ,
T2188 2532-2536 VBD denotes were
T2189 2537-2545 VBN denotes resolved
T2190 2545-2546 . denotes .
T2191 2547-2554 RB denotes Finally
T2192 2554-2555 , denotes ,
T2193 2556-2558 PRP denotes we
T2194 2559-2571 VBD denotes investigated
T2195 2572-2579 IN denotes whether
T2196 2580-2581 NNP denotes B
T2197 2582-2587 NNS denotes cells
T2198 2588-2592 RB denotes also
T2199 2593-2597 VBD denotes were
T2200 2598-2605 JJ denotes capable
T2201 2606-2608 IN denotes of
T2202 2609-2618 VBG denotes producing
T2203 2619-2624 NNP denotes BMP-6
T2204 2624-2625 . denotes .
R1326 T1736 T1730 conj β,Members
R1327 T1737 T1738 punct (,TGF-β
R1328 T1738 T1736 appos TGF-β,β
R1329 T1739 T1736 punct ),β
R1330 T1740 T1741 advmod superfamily,play
R1331 T1741 T1741 ROOT play,play
R1332 T1742 T1743 amod central,roles
R1333 T1743 T1741 dobj roles,play
R1334 T1744 T1741 prep in,play
R1335 T1745 T1744 pcomp controlling,in
R1336 T1746 T1747 amod cellular,proliferation
R1337 T1747 T1745 dobj proliferation,controlling
R1352 T1762 T1785 ccomp divided,constitute
R1353 T1763 T1762 prep into,divided
R1354 T1764 T1765 nummod three,subgroups
R1355 T1765 T1763 pobj subgroups,into
R1356 T1766 T1765 punct :,subgroups
R1357 T1767 T1765 appos TGF-β,subgroups
R1358 T1768 T1767 punct ",",TGF-β
R1359 T1769 T1770 det the,activins/inhibins
R1360 T1770 T1767 conj activins/inhibins,TGF-β
R1361 T1771 T1770 punct ",",activins/inhibins
R1362 T1772 T1770 cc and,activins/inhibins
R1363 T1773 T1776 det the,proteins
R1364 T1774 T1776 nmod bone,proteins
R1365 T1775 T1776 amod morphogenetic,proteins
R1366 T1776 T1770 conj proteins,activins/inhibins
R1367 T1777 T1778 punct (,BMPs
R1368 T1778 T1776 appos BMPs,proteins
R1369 T1779 T1776 punct ),proteins
R1370 T1780 T1776 punct ",",proteins
R1371 T1781 T1785 prep of,constitute
R1372 T1782 T1781 pobj which,of
R1373 T1783 T1784 det the,latter
R1374 T1784 T1785 nsubj latter,constitute
R1375 T1785 T1785 ROOT constitute,constitute
R1376 T1786 T1788 det the,family
R1377 T1787 T1788 amod largest,family
R1378 T1788 T1785 dobj family,constitute
R1379 T1789 T1785 punct .,constitute
R1380 T1790 T1791 nsubj BMPs,are
R1381 T1791 T1791 ROOT are,are
R1382 T1792 T1799 nummod 30,proteins
R1383 T1793 T1795 nummod 38,hetero
R1384 T1794 T1795 compound kDa,hetero
R1385 T1795 T1799 nmod hetero,proteins
R1386 T1796 T1795 punct -,hetero
R1387 T1797 T1795 cc or,hetero
R1388 T1798 T1799 amod homodimeric,proteins
R1389 T1799 T1791 attr proteins,are
R1390 T1800 T1801 advmod originally,identified
R1391 T1801 T1799 acl identified,proteins
R1392 T1802 T1801 agent by,identified
R1393 T1803 T1804 poss their,ability
R1394 T1804 T1802 pobj ability,by
R1395 T1805 T1806 aux to,induce
R1396 T1806 T1804 acl induce,ability
R1397 T1807 T1808 amod ectopic,cartilage
R1398 T1808 T1806 dobj cartilage,induce
R1399 T1809 T1808 cc and,cartilage
R1400 T1810 T1811 compound bone,formation
R1401 T1811 T1808 conj formation,cartilage
R1402 T1812 T1814 compound [,]
R1416 T1826 T1822 prep during,role
R1417 T1827 T1826 pobj embryogenesis,during
R1418 T1828 T1819 punct ",",demonstrated
R1419 T1829 T1819 cc and,demonstrated
R1420 T1830 T1831 advmod more,recently
R1421 T1831 T1837 advmod recently,[
R1422 T1832 T1837 punct ",",[
R1423 T1833 T1834 advmod also,in
R1424 T1834 T1837 prep in,[
R1425 T1835 T1836 compound adult,tissues
R1426 T1836 T1834 pobj tissues,in
R1427 T1837 T1819 conj [,demonstrated
R1428 T1838 T1839 nummod 1,]
R1429 T1839 T1837 dobj ],[
R1430 T1840 T1819 punct .,demonstrated
R1431 T1841 T1845 nsubjpass TGF-β,studied
R1432 T1842 T1845 aux has,studied
R1433 T1843 T1845 auxpass been,studied
R1434 T1844 T1845 advmod intensively,studied
R1435 T1845 T1845 ROOT studied,studied
R1436 T1846 T1845 prep in,studied
R1437 T1847 T1851 amod normal,cells
R1438 T1848 T1847 cc and,normal
R1439 T1849 T1847 conj malignant,normal
R1440 T1850 T1851 amod haematopoietic,cells
R1441 T1851 T1846 pobj cells,in
R1442 T1852 T1845 cc and,studied
R1443 T1853 T1845 conj is,studied
R1444 T1854 T1853 attr one,is
R1445 T1855 T1854 prep of,one
R1446 T1856 T1861 det the,regulators
R1447 T1857 T1858 advmod most,potent
R1448 T1858 T1861 amod potent,regulators
R1449 T1859 T1861 amod endogenous,regulators
R1450 T1860 T1861 amod negative,regulators
R1451 T1861 T1855 pobj regulators,of
R1452 T1862 T1861 acl known,regulators
R1453 T1863 T1862 prep to,known
R1454 T1864 T1863 pobj date,to
R1455 T1865 T1845 punct .,studied
R1456 T1866 T1866 ROOT [,[
R1457 T1867 T1866 nummod 4,[
R1458 T1868 T1868 ROOT ],]
R1459 T1869 T1866 punct .,[
R1460 T1870 T1885 prep In,investigated
R1461 T1871 T1870 pobj contrast,In
R1462 T1872 T1885 punct ",",investigated
R1463 T1873 T1874 det the,effect
R1464 T1874 T1885 nsubj effect,investigated
R1465 T1875 T1874 prep of,effect
R1466 T1876 T1875 pobj BMPs,of
R1467 T1877 T1876 prep in,BMPs
R1468 T1878 T1880 det the,system
R1469 T1879 T1880 amod immune,system
R1470 T1880 T1877 pobj system,in
R1471 T1881 T1885 aux has,investigated
R1472 T1882 T1885 neg not,investigated
R1473 T1883 T1885 auxpass been,investigated
R1474 T1884 T1885 advmod widely,investigated
R1475 T1885 T1885 ROOT investigated,investigated
R1476 T1886 T1885 punct .,investigated
R1477 T1887 T1900 prep In,found
R1478 T1888 T1889 det that,respect
R1479 T1889 T1887 pobj respect,In
R1480 T1890 T1900 punct ",",found
R1481 T1891 T1900 nsubjpass BMP,found
R1482 T1892 T1893 punct -,2
R1483 T1893 T1891 nummod 2,BMP
R1484 T1894 T1891 punct ",",BMP
R1485 T1895 T1891 nummod -4,BMP
R1486 T1896 T1891 cc and,BMP
R1487 T1897 T1891 conj -7,BMP
R1488 T1898 T1900 aux have,found
R1489 T1899 T1900 auxpass been,found
R1490 T1900 T1900 ROOT found,found
R1491 T1901 T1902 aux to,control
R1492 T1902 T1900 xcomp control,found
R1493 T1903 T1902 dobj differentiation,control
R1494 T1904 T1903 prep of,differentiation
R1495 T1905 T1907 amod hematopoietic,cells
R1496 T1906 T1907 compound stem,cells
R1497 T1907 T1904 pobj cells,of
R1498 T1908 T1910 nmod [,]
R1499 T1909 T1910 nummod 5,]
R1500 T1910 T1902 dobj ],control
R1501 T1911 T1910 cc and,]
R1502 T1912 T1915 amod early,development
R1503 T1913 T1915 compound T,development
R1504 T1914 T1915 compound cell,development
R1505 T1915 T1910 conj development,]
R1506 T1916 T1918 nmod [,]
R1507 T1917 T1918 nummod "6,7",]
R1508 T1918 T1910 conj ],]
R1509 T1919 T1900 punct .,found
R1510 T1920 T1923 nsubjpass BMP-6,reported
R1511 T1921 T1923 aux has,reported
R1512 T1922 T1923 auxpass been,reported
R1513 T1923 T1923 ROOT reported,reported
R1514 T1924 T1925 aux to,reduce
R1515 T1925 T1923 xcomp reduce,reported
R1516 T1926 T1927 det the,number
R1517 T1927 T1925 dobj number,reduce
R1518 T1928 T1927 prep of,number
R1519 T1929 T1930 amod cobblestone-area-forming,cells
R1520 T1930 T1928 pobj cells,of
R1521 T1931 T1930 prep of,cells
R1522 T1932 T1935 amod normal,cells
R1523 T1933 T1935 amod human,cells
R1524 T1934 T1935 amod haematopoietic,cells
R1525 T1935 T1931 pobj cells,of
R1526 T1936 T1925 conj [,reduce
R1527 T1937 T1938 nummod 8,]
R1528 T1938 T1936 dobj ],[
R1529 T1939 T1923 punct .,reported
R1530 T1940 T1949 advmod Furthermore,had
R1531 T1941 T1949 punct ",",had
R1532 T1942 T1949 nsubj BMP-2,had
R1533 T1943 T1942 punct ",",BMP-2
R1534 T1944 T1949 nsubj -4,had
R1535 T1945 T1946 punct ",",6
R1536 T1946 T1944 prep 6,-4
R1539 T1949 T1949 ROOT had,had
R1540 T1950 T1951 det an,antiproliferative
R1541 T1951 T1949 dobj antiproliferative,had
R1542 T1952 T1951 cc and,antiproliferative
R1543 T1953 T1955 det a,effect
R1544 T1954 T1955 amod proapoptotic,effect
R1545 T1955 T1951 conj effect,antiproliferative
R1546 T1956 T1955 prep on,effect
R1547 T1957 T1959 amod multiple,cells
R1548 T1958 T1959 compound myeloma,cells
R1549 T1959 T1956 pobj cells,on
R1550 T1960 T1962 compound [,]
R1551 T1961 T1962 compound 9-11,]
R1552 T1962 T1959 appos ],cells
R1553 T1963 T1949 punct .,had
R1554 T1964 T1974 prep In,increased
R1555 T1965 T1964 pobj addition,In
R1556 T1966 T1974 punct ",",increased
R1557 T1967 T1974 prep by,increased
R1558 T2004 T2003 punct ",",BMP-6
R1559 T1968 T1969 compound gene,expression
R1560 T2005 T2003 prep like,BMP-6
R1561 T2006 T2009 det the,members
R1562 T1969 T1967 pobj expression,by
R1563 T2007 T2009 amod other,members
R1564 T2008 T2009 compound BMP,members
R1565 T1970 T1974 advmod profiling,increased
R1566 T2009 T2005 pobj members,like
R1567 T2010 T2009 punct ",",members
R1568 T2011 T2011 ROOT signals,signals
R1569 T2012 T2011 prep through,signals
R1570 T2013 T2012 pobj ligation,through
R1571 T2014 T2013 cc and,ligation
R1572 T1971 T1974 punct ",",increased
R1573 T2015 T2013 conj heterodimerzation,ligation
R1574 T2016 T2015 prep of,heterodimerzation
R1575 T2017 T2018 compound BMP,type
R1576 T1972 T1974 nsubj BMP-6,increased
R1577 T2018 T2016 pobj type,of
R1578 T2019 T2020 nsubj I,[
R1579 T2020 T2011 advcl [,signals
R1580 T1973 T1974 advmod significantly,increased
R1581 T2021 T2020 acomp activin-like-kinase,[
R1582 T2022 T2021 punct (,activin-like-kinase
R1583 T2023 T2021 appos ALK,activin-like-kinase
R1584 T1974 T1974 ROOT increased,increased
R1585 T2024 T2023 punct ),ALK
R1586 T2025 T2021 conj ],activin-like-kinase
R1587 T2026 T2025 cc and,]
R1588 T2027 T2031 nmod type,receptors
R1589 T1975 T1977 det the,value
R1590 T2028 T2031 nmod II,receptors
R1591 T2029 T2031 amod serine-threonine,receptors
R1592 T1976 T1977 amod predictive,value
R1593 T2030 T2031 compound kinase,receptors
R1594 T2031 T2025 conj receptors,]
R1595 T2032 T2031 punct ",",receptors
R1596 T1977 T1974 dobj value,increased
R1597 T2033 T2035 nsubj which,propagates
R1598 T2034 T2035 advmod subsequently,propagates
R1599 T2035 T2031 relcl propagates,receptors
R1600 T2036 T2037 det the,signal
R1601 T1978 T1974 prep for,increased
R1602 T2037 T2035 dobj signal,propagates
R1603 T2038 T2037 amod downstream,signal
R1604 T2039 T2035 prep by,propagates
R1605 T2040 T2039 pcomp phosphorylating,by
R1606 T1979 T1982 det a,test
R1607 T2041 T2042 compound Smad,proteins
R1608 T2042 T2040 dobj proteins,phosphorylating
R1609 T2043 T2020 punct .,[
R1610 T1980 T1982 amod multi-gene,test
R1611 T2044 T2046 nsubj BMP-6,signal
R1612 T2045 T2046 aux can,signal
R1613 T2046 T2046 ROOT signal,signal
R1614 T1981 T1982 compound signature,test
R1615 T2047 T2046 prep through,signal
R1616 T2048 T2049 det the,ligation
R1617 T2049 T2047 pobj ligation,through
R1618 T2050 T2049 prep of,ligation
R1619 T2051 T2052 det the,type
R1620 T2052 T2050 pobj type,of
R1621 T1982 T1978 pobj test,for
R1622 T1983 T1974 cc and,increased
R1623 T2053 T2054 nsubj I,receptors
R1624 T1984 T1985 auxpass was,associated
R1625 T2054 T2052 relcl receptors,type
R1626 T1985 T1974 conj associated,increased
R1627 T2055 T2054 dobj Act-RIA,receptors
R1628 T1986 T1985 prep with,associated
R1629 T1987 T1989 det a,outcome
R1630 T2056 T2055 punct ",",Act-RIA
R1631 T1988 T1989 amod poor,outcome
R1632 T1989 T1986 pobj outcome,with
R1633 T2057 T2055 conj BMP-RIA,Act-RIA
R1634 T1990 T1989 prep in,outcome
R1635 T2058 T2057 punct ",",BMP-RIA
R1636 T2059 T2057 cc and,BMP-RIA
R1637 T1991 T1990 pobj diffuse,in
R1638 T2060 T2057 conj BMP-RIB,BMP-RIA
R1639 T2061 T2060 cc and,BMP-RIB
R1640 T2062 T2065 det the,receptors
R1641 T1992 T1995 amod large,lymphomas
R1642 T2063 T2065 compound type,receptors
R1643 T2064 T2065 compound II,receptors
R1644 T2065 T2054 conj receptors,receptors
R1645 T1993 T1994 compound B,cell
R1646 T2066 T2054 npadvmod BMP-RII,receptors
R1647 T2067 T2066 punct ",",BMP-RII
R1648 T2068 T2066 conj Act-RIIA,BMP-RII
R1649 T1994 T1995 compound cell,lymphomas
R1650 T2069 T2068 cc and,Act-RIIA
R1651 T2070 T2068 conj Act-RIIB,Act-RIIA
R1652 T1995 T1991 dobj lymphomas,diffuse
R1653 T2071 T2066 punct ",",BMP-RII
R1654 T2072 T2073 nsubj which,lead
R1655 T1996 T1997 punct (,DLBCL
R1656 T1997 T1995 appos DLBCL,lymphomas
R1657 T2073 T2066 relcl lead,BMP-RII
R1658 T2074 T2073 prep to,lead
R1659 T2075 T2076 det the,phosphorylation
R1660 T1998 T1985 punct ),associated
R1661 T2076 T2074 pobj phosphorylation,to
R1662 T2077 T2076 prep of,phosphorylation
R1663 T2078 T2080 det the,Smads
R1664 T1999 T2001 nmod [,]
R1665 T2079 T2080 compound receptor,Smads
R1666 T2080 T2077 pobj Smads,of
R1667 T2081 T2082 punct (,Smad-1
R1668 T2082 T2076 appos Smad-1,phosphorylation
R1669 T2083 T2082 punct ",",Smad-1
R1670 T2084 T2082 conj Smad-5,Smad-1
R1671 T2000 T2001 nummod 12,]
R1672 T2085 T2084 punct ",",Smad-5
R1673 T2086 T2084 cc and,Smad-5
R1674 T2087 T2084 conj Smad-8,Smad-5
R1675 T2088 T2084 punct ),Smad-5
R1676 T2001 T2001 ROOT ],]
R1677 T2089 T2046 punct .,signal
R1678 T2090 T2093 det The,Smads
R1679 T2091 T2093 compound R,Smads
R1680 T2002 T2001 punct .,]
R1681 T2092 T2093 punct -,Smads
R1682 T2093 T2095 nsubj Smads,form
R1683 T2094 T2095 advmod then,form
R1684 T2003 T2011 nsubj BMP-6,signals
R1685 T2095 T2095 ROOT form,form
R1686 T2096 T2095 dobj complexes,form
R1687 T2097 T2096 prep with,complexes
R1688 T2101 T2099 appos Smad4,co-Smad
R1689 T2098 T2099 det the,co-Smad
R1690 T2099 T2097 pobj co-Smad,with
R1691 T2100 T2099 punct (,co-Smad
R1692 T2102 T2099 punct ),co-Smad
R1693 T2103 T2095 cc and,form
R1694 T2104 T2105 auxpass are,translocated
R1695 T2198 T2199 advmod also,were
R1696 T2105 T2095 conj translocated,form
R1697 T2199 T2194 ccomp were,investigated
R1698 T2200 T2199 acomp capable,were
R1699 T2201 T2200 prep of,capable
R1700 T2106 T2105 prep into,translocated
R1701 T2202 T2201 pcomp producing,of
R1702 T2203 T2202 dobj BMP-6,producing
R1703 T2107 T2108 det the,nucleus
R1704 T2108 T2106 pobj nucleus,into
R1705 T2204 T2194 punct .,investigated
R1708 T2111 T2108 relcl exert,nucleus
R1709 T2112 T2113 compound gene,regulation
R1710 T2113 T2116 compound regulation,]
R1711 T2114 T2116 compound [,]
R1712 T2115 T2116 compound "1,13",]
R1713 T2116 T2111 dobj ],exert
R1714 T2117 T2095 punct .,form
R1715 T2118 T2133 prep Given,wanted
R1723 T2126 T2124 pobj malignancies,in
R1724 T2127 T2126 cc and,malignancies
R1725 T2128 T2130 amod haematopoietic,cells
R1726 T2129 T2130 compound progenitor,cells
R1727 T2130 T2126 conj cells,malignancies
R1728 T2131 T2133 punct ",",wanted
R1729 T2132 T2133 nsubj we,wanted
R1730 T2133 T2133 ROOT wanted,wanted
R1731 T2134 T2135 aux to,explore
R1732 T2135 T2133 xcomp explore,wanted
R1734 T2136 T2138 poss its,role
R1741 T2137 T2138 amod potential,role
R1745 T2138 T2135 dobj role,explore
R1748 T2139 T2138 prep in,role
R1749 T2140 T2143 amod normal,cells
R1751 T2141 T2143 amod human,cells
R1752 T2142 T2143 compound B,cells
R1755 T2143 T2139 pobj cells,in
R1759 T2144 T2133 punct .,wanted
R1763 T2145 T2146 nsubj We,studied
R1765 T2146 T2146 ROOT studied,studied
R1766 T2147 T2148 det the,effects
R1772 T2148 T2146 dobj effects,studied
R1776 T2149 T2148 prep of,effects
R1777 T2150 T2149 pobj BMP-6,of
R1784 T2151 T2148 prep on,effects
R1785 T2152 T2151 pobj proliferation,on
R1787 T2153 T2152 cc and,proliferation
R1789 T2154 T2152 conj apoptosis,proliferation
R1792 T2155 T2148 prep on,effects
R1794 T2156 T2155 pcomp resting,on
R1795 T2157 T2146 cc and,studied
R1796 T2158 T2146 conj stimulated,studied
R1797 T2159 T2160 compound B,cells
R1798 T2160 T2158 dobj cells,stimulated
R1799 T2161 T2146 punct .,studied
R1800 T2162 T2171 advmod Furthermore,induced
R1801 T2163 T2171 punct ",",induced
R1802 T2164 T2165 det the,expression
R1803 T2165 T2171 nsubj expression,induced
R1805 T2166 T2165 prep of,expression
R1808 T2167 T2168 compound BMP,receptors
R1810 T2168 T2166 pobj receptors,of
R1828 T2169 T2168 cc and,receptors
R1838 T2170 T2171 nsubj BMP-6,induced
R1841 T2171 T2171 ROOT induced,induced
R1843 T2172 T2171 dobj activation,induced
R1844 T2173 T2172 prep of,activation
R1845 T2174 T2177 det the,pathway
R1846 T2175 T2177 nmod Smad,pathway
R1847 T2176 T2177 amod signalling,pathway
R1848 T2177 T2173 pobj pathway,of
R1849 T2178 T2171 prep with,induced
R1880 T2179 T2180 amod subsequent,regulation
R1884 T2180 T2178 pobj regulation,with
R1885 T2181 T2180 prep of,regulation
R1886 T2182 T2184 det the,genes
R1889 T2183 T2184 compound target,genes
R1891 T2184 T2181 pobj genes,of
R1895 T2185 T2186 compound Id1,Id4
R1897 T2186 T2171 npadvmod Id4,induced
R1899 T2187 T2171 punct ",",induced
R1900 T2188 T2189 auxpass were,resolved
R1901 T2189 T2171 conj resolved,induced
R1902 T2190 T2171 punct .,induced
R1903 T2191 T2194 advmod Finally,investigated
R1904 T2192 T2194 punct ",",investigated
R1905 T2193 T2194 nsubj we,investigated
R1906 T2194 T2194 ROOT investigated,investigated
R1907 T2195 T2199 mark whether,were
R1908 T2196 T2197 compound B,cells
R1909 T2197 T2199 nsubj cells,were
R1537 T1947 T1944 cc and,-4
R1538 T1948 T1944 conj -7,-4
R1320 T1730 T1741 nsubj Members,play
R1321 T1731 T1730 prep of,Members
R1322 T1732 T1735 det the,factor
R1323 T1733 T1735 amod transforming,factor
R1324 T1734 T1735 compound growth,factor
R1325 T1735 T1731 pobj factor,of
R1338 T1748 T1747 punct ",",proliferation
R1339 T1749 T1747 conj differentiation,proliferation
R1340 T1750 T1749 punct ",",differentiation
R1341 T1751 T1749 conj migration,differentiation
R1342 T1752 T1751 cc and,migration
R1343 T1753 T1754 compound apoptosis,[
R1344 T1754 T1751 conj [,migration
R1345 T1755 T1756 nummod 1,]
R1346 T1756 T1754 appos ],[
R1347 T1757 T1741 punct .,play
R1348 T1758 T1759 det These,cytokines
R1349 T1759 T1762 nsubjpass cytokines,divided
R1350 T1760 T1762 aux can,divided
R1351 T1761 T1762 auxpass be,divided
R1403 T1813 T1814 compound "2,3",]
R1404 T1814 T1806 dobj ],induce
R1405 T1815 T1791 punct .,are
R1406 T1816 T1817 amod Several,studies
R1407 T1817 T1819 nsubj studies,demonstrated
R1408 T1818 T1819 aux have,demonstrated
R1409 T1819 T1819 ROOT demonstrated,demonstrated
R1410 T1820 T1822 det an,role
R1411 T1821 T1822 amod essential,role
R1412 T1822 T1819 dobj role,demonstrated
R1413 T1823 T1822 prep of,role
R1414 T1824 T1825 det these,proteins
R1415 T1825 T1823 pobj proteins,of
R1706 T2109 T2111 advmod where,exert
R1707 T2110 T2111 nsubj they,exert
R1716 T2119 T2121 det the,role
R1717 T2120 T2121 amod reported,role
R1718 T2121 T2118 pobj role,Given
R1719 T2122 T2121 prep of,role
R1720 T2123 T2122 pobj BMP-6,of
R1721 T2124 T2121 prep in,role
R1722 T2125 T2126 compound B-cell,malignancies

UBERON-AE

Id Subject Object Predicate Lexical cue
T1030 80-87 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T1031 626-633 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T1032 839-852 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T1033 1830-1833 http://purl.obolibrary.org/obo/UBERON_0002228 denotes RIB

GO-BP

Id Subject Object Predicate Lexical cue
T1061 578-591 http://purl.obolibrary.org/obo/GO_0009792 denotes embryogenesis
T1062 578-591 http://purl.obolibrary.org/obo/GO_0009793 denotes embryogenesis
T1063 1009-1025 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T1064 1014-1025 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1065 1288-1303 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T1066 1520-1527 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T1067 1690-1696 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T1068 1752-1758 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T1069 2457-2467 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T1070 1910-1925 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T1071 2096-2106 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1072 2492-2502 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1073 2457-2475 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T1051 39-45 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T1052 109-117 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T1053 164-173 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1054 2326-2335 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1055 164-173 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1056 2326-2335 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1057 270-297 http://purl.obolibrary.org/obo/GO_0038055 denotes bone morphogenetic proteins
T1058 479-493 http://purl.obolibrary.org/obo/GO_0001503 denotes bone formation
T1059 484-493 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T1060 578-591 http://purl.obolibrary.org/obo/GO_0009790 denotes embryogenesis

GO-MF

Id Subject Object Predicate Lexical cue
T2205 39-54 http://purl.obolibrary.org/obo/GO_0005160 denotes growth factor β
T2206 243-251 http://purl.obolibrary.org/obo/GO_0005160 denotes activins
T2207 252-260 http://purl.obolibrary.org/obo/GO_0005160 denotes inhibins

GO-CC

Id Subject Object Predicate Lexical cue
T2208 713-718 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2209 987-992 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2210 1106-1111 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2211 1143-1148 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2212 1258-1263 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2213 2201-2206 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2214 2266-2271 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2215 2364-2369 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2216 2582-2587 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2217 2066-2073 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus

sentences

Id Subject Object Predicate Lexical cue
T1034 11-178 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T1035 179-356 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T1036 357-500 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T1037 501-638 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T1038 639-799 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T1039 800-886 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T1040 887-1032 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T1041 1033-1153 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T1042 1154-1271 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T1043 1272-1484 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T1044 1485-1741 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T1045 1742-1977 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T1046 1978-2114 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T1047 2115-2272 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T1048 2273-2370 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T1049 2371-2546 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T1050 2547-2625 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.
T16 0-10 Sentence denotes Background
T17 11-178 Sentence denotes Members of the transforming growth factor β (TGF-β) superfamily play central roles in controlling cellular proliferation, differentiation, migration and apoptosis [1].
T18 179-356 Sentence denotes These cytokines can be divided into three subgroups: TGF-β, the activins/inhibins, and the bone morphogenetic proteins (BMPs), of which the latter constitute the largest family.
T19 357-500 Sentence denotes BMPs are 30–38 kDa hetero- or homodimeric proteins originally identified by their ability to induce ectopic cartilage and bone formation [2,3].
T20 501-638 Sentence denotes Several studies have demonstrated an essential role of these proteins during embryogenesis, and more recently, also in adult tissues [1].
T21 639-799 Sentence denotes TGF-β has been intensively studied in normal and malignant haematopoietic cells and is one of the most potent endogenous negative regulators known to date. [4].
T22 800-886 Sentence denotes In contrast, the effect of BMPs in the immune system has not been widely investigated.
T23 887-1032 Sentence denotes In that respect, BMP- 2, -4 and -7 have been found to control differentiation of hematopoietic stem cells [5] and early T cell development [6,7].
T24 1033-1153 Sentence denotes BMP-6 has been reported to reduce the number of cobblestone-area-forming cells of normal human haematopoietic cells [8].
T25 1154-1271 Sentence denotes Furthermore, BMP-2, -4, 6 and -7 had an antiproliferative and a proapoptotic effect on multiple myeloma cells [9-11].
T26 1272-1484 Sentence denotes In addition, by gene expression profiling, BMP-6 significantly increased the predictive value for a multi-gene signature test and was associated with a poor outcome in diffuse large B cell lymphomas (DLBCL) [12].
T27 1485-1741 Sentence denotes BMP-6, like the other BMP members, signals through ligation and heterodimerzation of BMP type I [activin-like-kinase (ALK)] and type II serine-threonine kinase receptors, which subsequently propagates the signal downstream by phosphorylating Smad proteins.
T28 1742-1977 Sentence denotes BMP-6 can signal through the ligation of the type I receptors Act-RIA, BMP-RIA, and BMP-RIB and the type II receptors BMP-RII, Act-RIIA and Act-RIIB, which lead to the phosphorylation of the receptor Smads (Smad-1, Smad-5, and Smad-8).
T29 1978-2114 Sentence denotes The R- Smads then form complexes with the co-Smad (Smad4) and are translocated into the nucleus where they exert gene regulation [1,13].
T30 2115-2272 Sentence denotes Given the reported role of BMP-6 in B-cell malignancies and haematopoietic progenitor cells, we wanted to explore its potential role in normal human B cells.
T31 2273-2370 Sentence denotes We studied the effects of BMP-6 on proliferation and apoptosis on resting and stimulated B cells.
T32 2371-2546 Sentence denotes Furthermore, the expression of BMP receptors and BMP-6 induced activation of the Smad signalling pathway with subsequent regulation of the target genes Id1–Id4, were resolved.
T33 2547-2625 Sentence denotes Finally, we investigated whether B cells also were capable of producing BMP-6.

ICD10

Id Subject Object Predicate Lexical cue
T2218 1241-1257 http://purl.bioontology.org/ontology/ICD10/C90.0 denotes multiple myeloma

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T2424 26-54 Protein denotes transforming growth factor β
T2425 56-61 Protein denotes TGF-β
T2426 232-237 Protein denotes TGF-β
T2427 639-644 Protein denotes TGF-β
T2428 904-910 Protein denotes BMP- 2
T2429 912-914 Protein denotes -4
T2430 919-921 Protein denotes -7
T2431 1033-1038 Protein denotes BMP-6
T2432 1167-1172 Protein denotes BMP-2
T2433 1174-1176 Protein denotes -4
T2434 1178-1179 Protein denotes 6
T2435 1184-1186 Protein denotes -7
T2436 1315-1320 Protein denotes BMP-6
T2437 1335-1344 Positive_regulation denotes increased
T2438 1485-1490 Protein denotes BMP-6
T2439 1536-1544 Binding denotes ligation
T2440 1549-1566 Binding denotes heterodimerzation
T2441 1742-1747 Protein denotes BMP-6
T2442 1771-1779 Binding denotes ligation
T2443 1771-1779 Binding denotes ligation
T2444 1771-1779 Binding denotes ligation
T2445 1771-1779 Binding denotes ligation
T2446 1771-1779 Binding denotes ligation
T2447 1771-1779 Binding denotes ligation
T2448 1804-1811 Protein denotes Act-RIA
T2449 1813-1820 Protein denotes BMP-RIA
T2450 1826-1833 Protein denotes BMP-RIB
T2451 1860-1867 Protein denotes BMP-RII
T2452 1869-1877 Protein denotes Act-RIIA
T2453 1882-1890 Protein denotes Act-RIIB
T2454 1898-1902 Positive_regulation denotes lead
T2455 1898-1902 Positive_regulation denotes lead
T2456 1898-1902 Positive_regulation denotes lead
T2457 1898-1902 Positive_regulation denotes lead
T2458 1898-1902 Positive_regulation denotes lead
T2459 1898-1902 Positive_regulation denotes lead
T2460 1898-1902 Positive_regulation denotes lead
T2461 1898-1902 Positive_regulation denotes lead
T2462 1898-1902 Positive_regulation denotes lead
T2463 1898-1902 Positive_regulation denotes lead
T2464 1898-1902 Positive_regulation denotes lead
T2465 1898-1902 Positive_regulation denotes lead
T2466 1898-1902 Positive_regulation denotes lead
T2467 1898-1902 Positive_regulation denotes lead
T2468 1898-1902 Positive_regulation denotes lead
T2469 1898-1902 Positive_regulation denotes lead
T2470 1898-1902 Positive_regulation denotes lead
T2471 1898-1902 Positive_regulation denotes lead
T2472 1910-1925 Phosphorylation denotes phosphorylation
T2473 1910-1925 Phosphorylation denotes phosphorylation
T2474 1910-1925 Phosphorylation denotes phosphorylation
T2475 1949-1955 Protein denotes Smad-1
T2476 1957-1963 Protein denotes Smad-5
T2477 1969-1975 Protein denotes Smad-8
T2478 1996-2010 Binding denotes form complexes
T2479 1996-2010 Binding denotes form complexes
T2480 1996-2010 Binding denotes form complexes
T2481 2029-2034 Protein denotes Smad4
T2482 2044-2056 Localization denotes translocated
T2483 2044-2056 Localization denotes translocated
T2484 2044-2056 Localization denotes translocated
T2485 2066-2073 Entity denotes nucleus
T2486 2142-2147 Protein denotes BMP-6
T2487 2299-2304 Protein denotes BMP-6
T2488 2388-2398 Gene_expression denotes expression
T2489 2420-2425 Protein denotes BMP-6
T2490 2426-2433 Positive_regulation denotes induced
T2491 2426-2433 Positive_regulation denotes induced
T2492 2492-2502 Regulation denotes regulation
T2493 2492-2502 Regulation denotes regulation
T2494 2523-2526 Protein denotes Id1
T2495 2527-2530 Protein denotes Id4
T2496 2609-2618 Gene_expression denotes producing true
T2497 2619-2624 Protein denotes BMP-6
R1979 T2472 T2455 themeOf phosphorylation,lead
R1980 T2472 T2456 themeOf phosphorylation,lead
R1981 T2472 T2457 themeOf phosphorylation,lead
R1982 T2472 T2458 themeOf phosphorylation,lead
R1983 T2472 T2459 themeOf phosphorylation,lead
R1984 T2473 T2460 themeOf phosphorylation,lead
R1985 T2473 T2461 themeOf phosphorylation,lead
R1942 T2436 T2437 themeOf BMP-6,increased
R1944 T2438 T2439 themeOf BMP-6,ligation
R1945 T2438 T2440 themeOf BMP-6,heterodimerzation
R1947 T2441 T2442 themeOf BMP-6,ligation
R1948 T2441 T2443 themeOf BMP-6,ligation
R1949 T2441 T2444 themeOf BMP-6,ligation
R1950 T2441 T2445 themeOf BMP-6,ligation
R1951 T2441 T2446 themeOf BMP-6,ligation
R1952 T2441 T2447 themeOf BMP-6,ligation
R1953 T2442 T2454 causeOf ligation,lead
R1954 T2442 T2460 causeOf ligation,lead
R1955 T2442 T2466 causeOf ligation,lead
R1956 T2443 T2455 causeOf ligation,lead
R1957 T2443 T2461 causeOf ligation,lead
R1958 T2443 T2467 causeOf ligation,lead
R1959 T2444 T2456 causeOf ligation,lead
R1960 T2444 T2462 causeOf ligation,lead
R1961 T2444 T2468 causeOf ligation,lead
R1962 T2445 T2457 causeOf ligation,lead
R1963 T2445 T2463 causeOf ligation,lead
R1964 T2445 T2469 causeOf ligation,lead
R1965 T2446 T2458 causeOf ligation,lead
R1966 T2446 T2464 causeOf ligation,lead
R1967 T2446 T2470 causeOf ligation,lead
R1968 T2447 T2459 causeOf ligation,lead
R1969 T2447 T2465 causeOf ligation,lead
R1970 T2447 T2471 causeOf ligation,lead
R1971 T2448 T2442 themeOf Act-RIA,ligation
R1972 T2449 T2443 themeOf BMP-RIA,ligation
R1973 T2450 T2444 themeOf BMP-RIB,ligation
R1974 T2451 T2445 themeOf BMP-RII,ligation
R1975 T2452 T2446 themeOf Act-RIIA,ligation
R1976 T2453 T2447 themeOf Act-RIIB,ligation
R1978 T2472 T2454 themeOf phosphorylation,lead
R1986 T2473 T2462 themeOf phosphorylation,lead
R1987 T2473 T2463 themeOf phosphorylation,lead
R1988 T2473 T2464 themeOf phosphorylation,lead
R1989 T2473 T2465 themeOf phosphorylation,lead
R1990 T2474 T2466 themeOf phosphorylation,lead
R1991 T2474 T2467 themeOf phosphorylation,lead
R1992 T2474 T2468 themeOf phosphorylation,lead
R1993 T2474 T2469 themeOf phosphorylation,lead
R1994 T2474 T2470 themeOf phosphorylation,lead
R1995 T2474 T2471 themeOf phosphorylation,lead
R1996 T2475 T2472 themeOf Smad-1,phosphorylation
R1997 T2475 T2478 themeOf Smad-1,form complexes
R1998 T2475 T2482 themeOf Smad-1,translocated
R2000 T2476 T2473 themeOf Smad-5,phosphorylation
R2001 T2476 T2479 themeOf Smad-5,form complexes
R2002 T2476 T2483 themeOf Smad-5,translocated
R2003 T2477 T2474 themeOf Smad-8,phosphorylation
R2004 T2477 T2480 themeOf Smad-8,form complexes
R2005 T2477 T2484 themeOf Smad-8,translocated
R2010 T2481 T2478 themeOf Smad4,form complexes
R2011 T2481 T2479 themeOf Smad4,form complexes
R2012 T2481 T2480 themeOf Smad4,form complexes
R2015 T2485 T2482 locationOf nucleus,translocated
R2016 T2485 T2483 locationOf nucleus,translocated
R2017 T2485 T2484 locationOf nucleus,translocated
R2021 T2488 T2490 causeOf expression,induced
R2022 T2488 T2491 causeOf expression,induced
R2023 T2489 T2488 themeOf BMP-6,expression
R2024 T2492 T2490 themeOf regulation,induced
R2026 T2493 T2491 themeOf regulation,induced
R2027 T2494 T2492 themeOf Id1,regulation
R2028 T2495 T2493 themeOf Id4,regulation
R2031 T2497 T2496 themeOf BMP-6,producing

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T2219 232-237 Protein denotes TGF-β
T2220 243-251 Protein denotes activins
T2221 252-260 Protein denotes inhibins
T2222 639-644 Protein denotes TGF-β
T2223 1033-1038 Protein denotes BMP-6
T2224 1536-1544 Binding denotes ligation
T2225 1536-1544 Binding denotes ligation
T2226 1536-1544 Binding denotes ligation
T2227 1549-1566 Binding denotes heterodimerzation
T2228 1549-1566 Binding denotes heterodimerzation
T2229 1581-1601 Protein denotes [activin-like-kinase
T2230 1603-1606 Protein denotes ALK
T2231 1613-1654 Protein denotes type II serine-threonine kinase receptors
T2232 1711-1726 Phosphorylation denotes phosphorylating
T2233 1727-1740 Protein denotes Smad proteins
T2234 1742-1747 Protein denotes BMP-6
T2235 1771-1779 Binding denotes ligation
T2236 1787-1803 Protein denotes type I receptors
T2237 1842-1867 Protein denotes type II receptors BMP-RII
T2238 1869-1877 Protein denotes Act-RIIA
T2239 1882-1890 Protein denotes Act-RIIB
T2240 1898-1902 Positive_regulation denotes lead
T2241 1898-1902 Positive_regulation denotes lead
T2242 1898-1902 Positive_regulation denotes lead
T2243 1898-1902 Positive_regulation denotes lead
T2244 1910-1925 Phosphorylation denotes phosphorylation
T2245 1910-1925 Phosphorylation denotes phosphorylation
T2246 1910-1925 Phosphorylation denotes phosphorylation
T2247 1910-1925 Phosphorylation denotes phosphorylation
T2248 1942-1947 Protein denotes Smads
T2249 1949-1955 Protein denotes Smad-1
T2250 1957-1963 Protein denotes Smad-5
T2251 1969-1975 Protein denotes Smad-8
T2252 2001-2010 Binding denotes complexes
T2253 2023-2027 Protein denotes Smad
T2254 2029-2034 Protein denotes Smad4
T2255 2066-2073 Entity denotes nucleus
T2256 2142-2147 Protein denotes BMP-6
T2257 2388-2398 Gene_expression denotes expression
T2258 2388-2398 Gene_expression denotes expression
T2259 2402-2415 Protein denotes BMP receptors
T2260 2420-2425 Protein denotes BMP-6
T2261 2426-2433 Positive_regulation denotes induced
T2262 2426-2433 Positive_regulation denotes induced
T2263 2426-2433 Positive_regulation denotes induced
T2264 2426-2433 Positive_regulation denotes induced
T2265 2426-2433 Positive_regulation denotes induced
T2266 2426-2433 Positive_regulation denotes induced
T2267 2434-2444 Positive_regulation denotes activation
T2268 2434-2444 Positive_regulation denotes activation
T2269 2452-2456 Protein denotes Smad
T2270 2492-2502 Regulation denotes regulation
T2271 2492-2502 Regulation denotes regulation
T2272 2523-2526 Protein denotes Id1
T2273 2527-2530 Protein denotes Id4
T2274 2609-2618 Gene_expression denotes producing
T2275 2619-2624 Protein denotes BMP-6
R1733 T2230 T2224 themeOf ALK,ligation
R1735 T2230 T2226 themeOf ALK,ligation
R1736 T2230 T2227 themeOf ALK,heterodimerzation
R1737 T2231 T2225 themeOf type II serine-threonine kinase receptors,ligation
R1738 T2231 T2226 themeOf type II serine-threonine kinase receptors,ligation
R1739 T2231 T2228 themeOf type II serine-threonine kinase receptors,heterodimerzation
R1740 T2233 T2232 themeOf Smad proteins,phosphorylating
R1742 T2234 T2235 themeOf BMP-6,ligation
R1743 T2235 T2242 causeOf ligation,lead
R1744 T2235 T2243 causeOf ligation,lead
R1746 T2235 T2240 causeOf ligation,lead
R1747 T2235 T2241 causeOf ligation,lead
R1750 T2239 T2235 themeOf Act-RIIB,ligation
R1753 T2244 T2240 themeOf phosphorylation,lead
R1754 T2245 T2241 themeOf phosphorylation,lead
R1756 T2246 T2242 themeOf phosphorylation,lead
R1757 T2247 T2243 themeOf phosphorylation,lead
R1758 T2248 T2244 themeOf Smads,phosphorylation
R1760 T2249 T2245 themeOf Smad-1,phosphorylation
R1761 T2250 T2246 themeOf Smad-5,phosphorylation
R1762 T2251 T2247 themeOf Smad-8,phosphorylation
R1764 T2253 T2252 themeOf Smad,complexes
R1767 T2257 T2263 causeOf expression,induced
R1768 T2257 T2264 causeOf expression,induced
R1769 T2258 T2265 causeOf expression,induced
R1770 T2258 T2266 causeOf expression,induced
R1771 T2259 T2257 themeOf BMP receptors,expression
R1773 T2260 T2258 themeOf BMP-6,expression
R1774 T2260 T2261 causeOf BMP-6,induced
R1775 T2260 T2262 causeOf BMP-6,induced
R1778 T2267 T2263 themeOf activation,induced
R1779 T2267 T2265 themeOf activation,induced
R1780 T2267 T2261 themeOf activation,induced
R1781 T2268 T2264 themeOf activation,induced
R1782 T2268 T2266 themeOf activation,induced
R1783 T2268 T2262 themeOf activation,induced
R1786 T2270 T2267 themeOf regulation,activation
R1788 T2271 T2268 themeOf regulation,activation
R1790 T2272 T2270 themeOf Id1,regulation
R1791 T2273 T2271 themeOf Id4,regulation
R1793 T2275 T2274 themeOf BMP-6,producing

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T1074 1335-1344 Positive_regulation denotes increased
T1075 1898-1902 Positive_regulation denotes lead
T1076 1910-1925 Phosphorylation denotes phosphorylation
T1077 1898-1902 Positive_regulation denotes lead
T1078 1898-1902 Positive_regulation denotes lead
T1079 1898-1902 Positive_regulation denotes lead
T1080 1898-1902 Positive_regulation denotes lead
T1081 1898-1902 Positive_regulation denotes lead
T1082 1898-1902 Positive_regulation denotes lead
T1083 1910-1925 Phosphorylation denotes phosphorylation
T1084 1898-1902 Positive_regulation denotes lead
T1085 1536-1544 Binding denotes ligation
T1086 1898-1902 Positive_regulation denotes lead
T1087 1898-1902 Positive_regulation denotes lead
T1088 1898-1902 Positive_regulation denotes lead
T1089 1898-1902 Positive_regulation denotes lead
T1090 1898-1902 Positive_regulation denotes lead
T1091 1910-1925 Phosphorylation denotes phosphorylation
T1092 1898-1902 Positive_regulation denotes lead
T1093 1898-1902 Positive_regulation denotes lead
T1094 1898-1902 Positive_regulation denotes lead
T1095 1898-1902 Positive_regulation denotes lead
T1096 1549-1566 Binding denotes heterodimerzation
T1097 1898-1902 Positive_regulation denotes lead
T1098 1996-2010 Binding denotes form complexes
T1099 1996-2010 Binding denotes form complexes
T1100 1996-2010 Binding denotes form complexes
T1101 2044-2056 Localization denotes translocated
T1102 2044-2056 Localization denotes translocated
T1103 2044-2056 Localization denotes translocated
T1104 2388-2398 Gene_expression denotes expression
T1105 2426-2433 Positive_regulation denotes induced
T1106 2492-2502 Regulation denotes regulation
T1107 1771-1779 Binding denotes ligation
T1108 2426-2433 Positive_regulation denotes induced
T1109 2492-2502 Regulation denotes regulation
T1110 2609-2618 Gene_expression denotes producing true
T1111 1771-1779 Binding denotes ligation
T1112 1771-1779 Binding denotes ligation
T1113 1771-1779 Binding denotes ligation
T1114 1771-1779 Binding denotes ligation
T1115 1771-1779 Binding denotes ligation
T1116 26-54 Protein denotes transforming growth factor β
T1117 1174-1176 Protein denotes -4
T1118 1178-1179 Protein denotes 6
T1119 1184-1186 Protein denotes -7
T1120 1315-1320 Protein denotes BMP-6
T1121 1485-1490 Protein denotes BMP-6
T1122 1742-1747 Protein denotes BMP-6
T1123 1804-1811 Protein denotes Act-RIA
T1124 1813-1820 Protein denotes BMP-RIA
T1125 1826-1833 Protein denotes BMP-RIB
T1126 1860-1867 Protein denotes BMP-RII
T1127 56-61 Protein denotes TGF-β
T1128 1869-1877 Protein denotes Act-RIIA
T1129 1882-1890 Protein denotes Act-RIIB
T1130 1949-1955 Protein denotes Smad-1
T1131 1957-1963 Protein denotes Smad-5
T1132 1969-1975 Protein denotes Smad-8
T1133 2029-2034 Protein denotes Smad4
T1134 2142-2147 Protein denotes BMP-6
T1135 2299-2304 Protein denotes BMP-6
T1136 2420-2425 Protein denotes BMP-6
T1137 2523-2526 Protein denotes Id1
T1138 2527-2530 Protein denotes Id4
T1139 2619-2624 Protein denotes BMP-6
T1140 639-644 Protein denotes TGF-β
T1141 2066-2073 Entity denotes nucleus
T1142 904-910 Protein denotes BMP- 2
T1143 912-914 Protein denotes -4
T1144 919-921 Protein denotes -7
T1145 1033-1038 Protein denotes BMP-6
T1146 1167-1172 Protein denotes BMP-2
T1147 232-237 Protein denotes TGF-β
R775 T1076 T1075 themeOf phosphorylation,lead
R776 T1076 T1077 themeOf phosphorylation,lead
R777 T1076 T1078 themeOf phosphorylation,lead
R778 T1076 T1079 themeOf phosphorylation,lead
R779 T1076 T1080 themeOf phosphorylation,lead
R780 T1076 T1081 themeOf phosphorylation,lead
R781 T1083 T1082 themeOf phosphorylation,lead
R794 T1104 T1108 causeOf expression,induced
R795 T1106 T1105 themeOf regulation,induced
R796 T1107 T1075 causeOf ligation,lead
R797 T1107 T1082 causeOf ligation,lead
R798 T1107 T1090 causeOf ligation,lead
R799 T1109 T1108 themeOf regulation,induced
R800 T1111 T1077 causeOf ligation,lead
R801 T1111 T1084 causeOf ligation,lead
R802 T1111 T1092 causeOf ligation,lead
R803 T1112 T1078 causeOf ligation,lead
R804 T1112 T1086 causeOf ligation,lead
R805 T1112 T1093 causeOf ligation,lead
R806 T1113 T1079 causeOf ligation,lead
R807 T1113 T1087 causeOf ligation,lead
R808 T1113 T1094 causeOf ligation,lead
R809 T1114 T1080 causeOf ligation,lead
R810 T1114 T1088 causeOf ligation,lead
R811 T1114 T1095 causeOf ligation,lead
R812 T1115 T1081 causeOf ligation,lead
R813 T1115 T1089 causeOf ligation,lead
R814 T1115 T1097 causeOf ligation,lead
R815 T1120 T1074 themeOf BMP-6,increased
R816 T1121 T1085 themeOf BMP-6,ligation
R817 T1121 T1096 themeOf BMP-6,heterodimerzation
R818 T1122 T1107 themeOf BMP-6,ligation
R819 T1122 T1111 themeOf BMP-6,ligation
R820 T1122 T1112 themeOf BMP-6,ligation
R821 T1122 T1113 themeOf BMP-6,ligation
R822 T1122 T1114 themeOf BMP-6,ligation
R823 T1122 T1115 themeOf BMP-6,ligation
R824 T1123 T1107 themeOf Act-RIA,ligation
R825 T1124 T1111 themeOf BMP-RIA,ligation
R826 T1125 T1112 themeOf BMP-RIB,ligation
R827 T1126 T1113 themeOf BMP-RII,ligation
R828 T1128 T1114 themeOf Act-RIIA,ligation
R829 T1129 T1115 themeOf Act-RIIB,ligation
R830 T1130 T1076 themeOf Smad-1,phosphorylation
R831 T1130 T1098 themeOf Smad-1,form complexes
R832 T1130 T1101 themeOf Smad-1,translocated
R833 T1131 T1083 themeOf Smad-5,phosphorylation
R834 T1131 T1099 themeOf Smad-5,form complexes
R835 T1131 T1102 themeOf Smad-5,translocated
R836 T1132 T1091 themeOf Smad-8,phosphorylation
R837 T1132 T1100 themeOf Smad-8,form complexes
R838 T1132 T1103 themeOf Smad-8,translocated
R839 T1133 T1098 themeOf Smad4,form complexes
R840 T1133 T1099 themeOf Smad4,form complexes
R841 T1133 T1100 themeOf Smad4,form complexes
R842 T1136 T1104 themeOf BMP-6,expression
R843 T1137 T1106 themeOf Id1,regulation
R844 T1138 T1109 themeOf Id4,regulation
R845 T1139 T1110 themeOf BMP-6,producing
R846 T1141 T1101 locationOf nucleus,translocated
R847 T1141 T1102 locationOf nucleus,translocated
R848 T1141 T1103 locationOf nucleus,translocated
R782 T1083 T1084 themeOf phosphorylation,lead
R783 T1083 T1086 themeOf phosphorylation,lead
R784 T1083 T1087 themeOf phosphorylation,lead
R785 T1083 T1088 themeOf phosphorylation,lead
R786 T1083 T1089 themeOf phosphorylation,lead
R787 T1091 T1090 themeOf phosphorylation,lead
R788 T1091 T1092 themeOf phosphorylation,lead
R789 T1091 T1093 themeOf phosphorylation,lead
R790 T1091 T1094 themeOf phosphorylation,lead
R791 T1091 T1095 themeOf phosphorylation,lead
R792 T1091 T1097 themeOf phosphorylation,lead
R793 T1104 T1105 causeOf expression,induced

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T1608 26-54 P01137 denotes transforming growth factor β
T1609 56-61 P01137 denotes TGF-β
T1610 232-237 P01137 denotes TGF-β
T1611 270-297 P12643 denotes bone morphogenetic proteins
T1612 270-297 P22004 denotes bone morphogenetic proteins
T1613 270-297 P12644 denotes bone morphogenetic proteins
T1614 270-297 P18075 denotes bone morphogenetic proteins
T1615 299-303 P22004 denotes BMPs
T1616 299-303 P12643 denotes BMPs
T1617 299-303 P12644 denotes BMPs
T1618 299-303 P18075 denotes BMPs
T1619 357-361 P12643 denotes BMPs
T1620 357-361 P18075 denotes BMPs
T1621 357-361 P12644 denotes BMPs
T1622 357-361 P22004 denotes BMPs
T1623 639-644 P01137 denotes TGF-β
T1624 827-831 P12643 denotes BMPs
T1625 827-831 P18075 denotes BMPs
T1626 827-831 P12644 denotes BMPs
T1627 827-831 P22004 denotes BMPs
T1628 904-907 P22004 denotes BMP
T1629 904-907 P12644 denotes BMP
T1630 904-907 P12643 denotes BMP
T1631 904-907 P18075 denotes BMP
T1632 1033-1036 P12643 denotes BMP
T1633 1033-1036 P22004 denotes BMP
T1634 1033-1036 P18075 denotes BMP
T1635 1033-1036 P12644 denotes BMP
T1636 1033-1038 P22004 denotes BMP-6
T1637 1167-1170 P22004 denotes BMP
T1638 1167-1170 P18075 denotes BMP
T1639 1167-1170 P12644 denotes BMP
T1640 1167-1170 P12643 denotes BMP
T1641 1167-1172 P12643 denotes BMP-2
T1642 1315-1318 P12643 denotes BMP
T1643 1315-1318 P18075 denotes BMP
T1644 1315-1318 P12644 denotes BMP
T1645 1315-1318 P22004 denotes BMP
T1646 1315-1320 P22004 denotes BMP-6
T1647 1485-1488 P22004 denotes BMP
T1648 1485-1488 P12644 denotes BMP
T1649 1485-1488 P12643 denotes BMP
T1650 1485-1488 P18075 denotes BMP
T1651 1485-1490 P22004 denotes BMP-6
T1652 1507-1510 P12643 denotes BMP
T1653 1507-1510 P22004 denotes BMP
T1654 1507-1510 P18075 denotes BMP
T1655 1507-1510 P12644 denotes BMP
T1656 1570-1573 P18075 denotes BMP
T1657 1570-1573 P22004 denotes BMP
T1658 1570-1573 P12643 denotes BMP
T1659 1570-1573 P12644 denotes BMP
T1660 1742-1745 P22004 denotes BMP
T1661 1742-1745 P12644 denotes BMP
T1662 1742-1745 P12643 denotes BMP
T1663 1742-1745 P18075 denotes BMP
T1664 1742-1747 P22004 denotes BMP-6
T1665 1804-1811 Q04771 denotes Act-RIA
T1666 1813-1816 P18075 denotes BMP
T1667 1813-1816 P22004 denotes BMP
T1668 1813-1816 P12644 denotes BMP
T1669 1813-1816 P12643 denotes BMP
T1670 1813-1820 P36894 denotes BMP-RIA
T1671 1826-1829 P18075 denotes BMP
T1672 1826-1829 P22004 denotes BMP
T1673 1826-1829 P12643 denotes BMP
T1674 1826-1829 P12644 denotes BMP
T1675 1826-1833 O00238 denotes BMP-RIB
T1676 1860-1863 P22004 denotes BMP
T1677 1860-1863 P12643 denotes BMP
T1678 1860-1863 P12644 denotes BMP
T1679 1860-1863 P18075 denotes BMP
T1680 1860-1867 Q13873 denotes BMP-RII
T1681 1869-1877 P27037 denotes Act-RIIA
T1682 1882-1890 Q13705 denotes Act-RIIB
T1683 1949-1955 Q15797 denotes Smad-1
T1684 1957-1963 Q99717 denotes Smad-5
T1685 1969-1975 Q9JIW5 denotes Smad-8
T1686 2029-2034 Q13485 denotes Smad4
T1687 2142-2145 P22004 denotes BMP
T1688 2142-2145 P18075 denotes BMP
T1689 2142-2145 P12644 denotes BMP
T1690 2142-2145 P12643 denotes BMP
T1691 2142-2147 P22004 denotes BMP-6
T1692 2299-2302 P18075 denotes BMP
T1693 2299-2302 P12644 denotes BMP
T1694 2299-2302 P22004 denotes BMP
T1695 2299-2302 P12643 denotes BMP
T1696 2299-2304 P22004 denotes BMP-6
T1697 2402-2405 P12644 denotes BMP
T1698 2402-2405 P22004 denotes BMP
T1699 2402-2405 P18075 denotes BMP
T1700 2402-2405 P12643 denotes BMP
T1701 2420-2423 P18075 denotes BMP
T1702 2420-2423 P12644 denotes BMP
T1703 2420-2423 P12643 denotes BMP
T1704 2420-2423 P22004 denotes BMP
T1705 2420-2425 P22004 denotes BMP-6
T1706 2523-2526 P41134 denotes Id1
T1707 2527-2530 P47928 denotes Id4
T1708 2619-2622 P12644 denotes BMP
T1709 2619-2622 P22004 denotes BMP
T1710 2619-2622 P18075 denotes BMP
T1711 2619-2622 P12643 denotes BMP
T1712 2619-2624 P22004 denotes BMP-6

tees-test

Id Subject Object Predicate Lexical cue
T207 26-54 D016212 denotes transforming growth factor β
T208 26-54 D016212 denotes transforming growth factor β
T209 26-54 PR:000000046 denotes transforming growth factor β
T210 26-54 GO:0005160 denotes transforming growth factor β
T211 56-61 D016212 denotes TGF-β
T212 56-61 D016212 denotes TGF-β
T213 56-74 PR:000000008 denotes TGF-β) superfamily
T214 118-131 UBERON:2000098 denotes proliferation
T215 164-173 GO:0097194 denotes apoptosis
T216 164-173 GO:0006915 denotes apoptosis
T217 185-194 D016207 denotes cytokines
T218 185-194 D016207 denotes cytokines
T219 232-237 D016212 denotes TGF-β
T220 232-237 D016212 denotes TGF-β
T221 232-237 PR:000000046 denotes TGF-β
T222 243-251 D028341 denotes activins
T223 252-260 D007265 denotes inhibins
T224 252-260 D007265 denotes inhibins
T225 270-274 UBERON:0001474 denotes bone
T226 270-274 UBERON:0002481 denotes bone
T227 270-297 D019485 denotes bone morphogenetic proteins
T228 270-297 D019485 denotes bone morphogenetic proteins
T229 399-407 CHEBI:36080 denotes proteins
T230 465-474 UBERON:0002418 denotes cartilage
T231 465-474 UBERON:0007844 denotes cartilage
T232 479-483 UBERON:0001474 denotes bone
T233 479-483 UBERON:0002481 denotes bone
T234 479-493 GO:0001503 denotes bone formation
T235 562-570 CHEBI:36080 denotes proteins
T236 578-591 GO:0009792 denotes embryogenesis
T237 578-591 GO:0009793 denotes embryogenesis
T238 578-591 GO:0009790 denotes embryogenesis
T239 578-591 UBERON:0000068 denotes embryogenesis
T240 620-625 UBERON:0007023 denotes adult
T241 639-644 PR:000000046 denotes TGF-β
T242 639-644 D016212 denotes TGF-β
T243 639-644 D016212 denotes TGF-β
T244 839-852 D007154 denotes immune system
T245 839-852 D007154 denotes immune system
T246 839-852 UBERON:0002405 denotes immune system
T247 904-907 CHEBI:60815 denotes BMP
T248 904-910 PR:P49001 denotes BMP- 2
T249 904-910 PR:P21274 denotes BMP- 2
T250 904-910 Q804S2 denotes BMP- 2
T251 904-910 P49001 denotes BMP- 2
T252 904-910 P12643 denotes BMP- 2
T253 904-910 P21274 denotes BMP- 2
T254 904-910 Q90751 denotes BMP- 2
T255 904-910 O46564 denotes BMP- 2
T256 904-910 PR:P12643 denotes BMP- 2
T257 904-910 PR:000000164 denotes BMP- 2
T258 904-910 O19006 denotes BMP- 2
T259 1007-1013 CL:0000084 denotes T cell
T260 1007-1025 GO:0030217 denotes T cell development
T261 1033-1038 D055418 denotes BMP-6
T262 1033-1038 D055418 denotes BMP-6
T263 1033-1038 Q04906 denotes BMP-6
T264 1033-1038 PR:000000167 denotes BMP-6
T265 1033-1038 P20722 denotes BMP-6
T266 1033-1038 PR:Q04906 denotes BMP-6
T267 1033-1038 P22004 denotes BMP-6
T268 1033-1038 PR:P22004 denotes BMP-6
T269 1033-1038 PR:P20722 denotes BMP-6
T270 1122-1127 D006801 denotes human
T271 1167-1170 CHEBI:60815 denotes BMP
T272 1167-1172 PR:P49001 denotes BMP-2
T273 1167-1172 PR:P21274 denotes BMP-2
T274 1167-1172 Q804S2 denotes BMP-2
T275 1167-1172 P49001 denotes BMP-2
T276 1167-1172 P12643 denotes BMP-2
T277 1167-1172 P21274 denotes BMP-2
T278 1167-1172 Q90751 denotes BMP-2
T279 1167-1172 O46564 denotes BMP-2
T280 1167-1172 PR:P12643 denotes BMP-2
T281 1167-1172 PR:000000164 denotes BMP-2
T282 1167-1172 O19006 denotes BMP-2
T283 1241-1257 D009101 denotes multiple myeloma
T284 1241-1257 D009101 denotes multiple myeloma
T285 1288-1292 SO:0000704 denotes gene
T286 1288-1303 GO:0010467 denotes gene expression
T287 1315-1320 D055418 denotes BMP-6
T288 1315-1320 D055418 denotes BMP-6
T289 1315-1320 Q04906 denotes BMP-6
T290 1315-1320 PR:000000167 denotes BMP-6
T291 1315-1320 P20722 denotes BMP-6
T292 1315-1320 PR:Q04906 denotes BMP-6
T293 1315-1320 P22004 denotes BMP-6
T294 1315-1320 PR:P22004 denotes BMP-6
T295 1315-1320 PR:P20722 denotes BMP-6
T296 1378-1382 SO:0000704 denotes gene
T297 1383-1392 SO:0001978 denotes signature
T298 1454-1460 CL:0000236 denotes B cell
T299 1454-1470 D016393 denotes B cell lymphomas
T300 1454-1470 D016393 denotes B cell lymphomas
T301 1485-1490 D055418 denotes BMP-6
T302 1485-1490 D055418 denotes BMP-6
T303 1485-1490 Q04906 denotes BMP-6
T304 1485-1490 PR:000000167 denotes BMP-6
T305 1485-1490 P20722 denotes BMP-6
T306 1485-1490 PR:Q04906 denotes BMP-6
T307 1485-1490 P22004 denotes BMP-6
T308 1485-1490 PR:P22004 denotes BMP-6
T309 1485-1490 PR:P20722 denotes BMP-6
T310 1507-1510 CHEBI:60815 denotes BMP
T311 1507-1510 PR:000000034 denotes BMP
T312 1507-1510 P35855 denotes BMP
T313 1570-1573 CHEBI:60815 denotes BMP
T314 1570-1573 PR:000000034 denotes BMP
T315 1570-1573 P35855 denotes BMP
T316 1582-1589 D028341 denotes activin
T317 1582-1589 GO:0016915 denotes activin
T318 1582-1589 GO:0005160 denotes activin
T319 1603-1606 PR:P97793 denotes ALK
T320 1603-1606 PR:000001282 denotes ALK
T321 1603-1606 PR:Q9UM73 denotes ALK
T322 1621-1627 9671 denotes serine
T323 1621-1627 SO:0001444 denotes serine
T324 1621-1644 D017346 denotes serine-threonine kinase
T325 1628-1637 10524 denotes threonine
T326 1628-1637 SO:0001445 denotes threonine
T327 1690-1696 SO:0000725 denotes signal
T328 1690-1696 SO:0000418 denotes signal
T329 1697-1707 SO:0001633 denotes downstream
T330 1727-1740 D051785 denotes Smad proteins
T331 1742-1747 D055418 denotes BMP-6
T332 1742-1747 D055418 denotes BMP-6
T333 1742-1747 Q04906 denotes BMP-6
T334 1742-1747 PR:000000167 denotes BMP-6
T335 1742-1747 P20722 denotes BMP-6
T336 1742-1747 PR:Q04906 denotes BMP-6
T337 1742-1747 P22004 denotes BMP-6
T338 1742-1747 PR:P22004 denotes BMP-6
T339 1742-1747 PR:P20722 denotes BMP-6
T340 1752-1758 SO:0000725 denotes signal
T341 1752-1758 SO:0000418 denotes signal
T342 1813-1816 CHEBI:60815 denotes BMP
T343 1813-1816 PR:000000034 denotes BMP
T344 1813-1816 P35855 denotes BMP
T345 1826-1829 CHEBI:60815 denotes BMP
T346 1826-1829 PR:000000034 denotes BMP
T347 1826-1829 P35855 denotes BMP
T348 1830-1833 CHEBI:33942 denotes RIB
T349 1830-1833 UBERON:0002228 denotes RIB
T350 1850-1863 D052004 denotes receptors BMP
T351 1860-1863 PR:000000034 denotes BMP
T352 1860-1863 P35855 denotes BMP
T353 1910-1925 GO:0016310 denotes phosphorylation
T354 1949-1955 PR:Q9I8V2 denotes Smad-1
T355 1949-1955 PR:P97588 denotes Smad-1
T356 1949-1955 Q15797 denotes Smad-1
T357 1949-1955 PR:000000363 denotes Smad-1
T358 1949-1955 PR:P70340 denotes Smad-1
T359 1949-1955 P70340 denotes Smad-1
T360 1949-1955 Q9I962 denotes Smad-1
T361 1949-1955 PR:Q15797 denotes Smad-1
T362 1949-1955 P97588 denotes Smad-1
T363 1949-1955 Q9I8V2 denotes Smad-1
T364 1949-1955 Q1JQA2 denotes Smad-1
T365 1957-1963 PR:P97454 denotes Smad-5
T366 1957-1963 PR:Q9R1V3 denotes Smad-5
T367 1957-1963 PR:Q9W7E7 denotes Smad-5
T368 1957-1963 Q5R6H7 denotes Smad-5
T369 1957-1963 Q56I99 denotes Smad-5
T370 1957-1963 Q9W7E7 denotes Smad-5
T371 1957-1963 PR:Q56I99 denotes Smad-5
T372 1957-1963 Q99717 denotes Smad-5
T373 1957-1963 P97454 denotes Smad-5
T374 1957-1963 Q9R1V3 denotes Smad-5
T375 1957-1963 PR:Q99717 denotes Smad-5
T376 1957-1963 PR:000000372 denotes Smad-5
T377 1969-1975 Q9JIW5 denotes Smad-8
T378 1969-1975 PR:O54835 denotes Smad-8
T379 1969-1975 PR:000000375 denotes Smad-8
T380 1969-1975 PR:Q9JIW5 denotes Smad-8
T381 1969-1975 O54835 denotes Smad-8
T382 1969-1975 PR:O15198 denotes Smad-8
T383 2029-2034 Q13485 denotes Smad4
T384 2029-2034 PR:P97471 denotes Smad4
T385 2029-2034 P97471 denotes Smad4
T386 2029-2034 O70437 denotes Smad4
T387 2029-2034 Q1HE26 denotes Smad4
T388 2029-2034 PR:O70437 denotes Smad4
T389 2029-2034 Q9GKQ9 denotes Smad4
T390 2029-2034 PR:000000128 denotes Smad4
T391 2029-2034 PR:Q13485 denotes Smad4
T392 2066-2073 CHEBI:33252 denotes nucleus
T393 2066-2073 UBERON:0000125 denotes nucleus
T394 2066-2073 GO:0005634 denotes nucleus
T395 2091-2095 SO:0000704 denotes gene
T396 2096-2106 GO:0065007 denotes regulation
T397 2142-2147 D055418 denotes BMP-6
T398 2142-2147 D055418 denotes BMP-6
T399 2142-2147 Q04906 denotes BMP-6
T400 2142-2147 PR:000000167 denotes BMP-6
T401 2142-2147 P20722 denotes BMP-6
T402 2142-2147 PR:Q04906 denotes BMP-6
T403 2142-2147 P22004 denotes BMP-6
T404 2142-2147 PR:P22004 denotes BMP-6
T405 2142-2147 PR:P20722 denotes BMP-6
T406 2151-2157 CL:0000236 denotes B-cell
T407 2158-2170 D009369 denotes malignancies
T408 2158-2170 D009369 denotes malignancies
T409 2258-2263 D006801 denotes human
T410 2299-2304 D055418 denotes BMP-6
T411 2299-2304 D055418 denotes BMP-6
T412 2299-2304 Q04906 denotes BMP-6
T413 2299-2304 PR:000000167 denotes BMP-6
T414 2299-2304 P20722 denotes BMP-6
T415 2299-2304 PR:Q04906 denotes BMP-6
T416 2299-2304 P22004 denotes BMP-6
T417 2299-2304 PR:P22004 denotes BMP-6
T418 2299-2304 PR:P20722 denotes BMP-6
T419 2308-2321 UBERON:2000098 denotes proliferation
T420 2326-2335 GO:0097194 denotes apoptosis
T421 2326-2335 GO:0006915 denotes apoptosis
T422 2402-2405 PR:000000034 denotes BMP
T423 2402-2405 P35855 denotes BMP
T424 2402-2415 D052004 denotes BMP receptors
T425 2420-2425 D055418 denotes BMP-6
T426 2420-2425 D055418 denotes BMP-6
T427 2420-2425 Q04906 denotes BMP-6
T428 2420-2425 PR:000000167 denotes BMP-6
T429 2420-2425 P20722 denotes BMP-6
T430 2420-2425 PR:Q04906 denotes BMP-6
T431 2420-2425 P22004 denotes BMP-6
T432 2420-2425 PR:P22004 denotes BMP-6
T433 2420-2425 PR:P20722 denotes BMP-6
T434 2457-2475 GO:0007165 denotes signalling pathway
T435 2468-2475 CHEBI:34922 denotes pathway
T436 2492-2502 GO:0065007 denotes regulation
T437 2523-2526 PR:P41134 denotes Id1
T438 2523-2526 PR:P20067 denotes Id1
T439 2523-2526 PR:P41135 denotes Id1
T440 2523-2526 PR:000000039 denotes Id1
T441 2527-2530 PR:P47928 denotes Id4
T442 2527-2530 PR:P41139 denotes Id4
T443 2527-2530 PR:000000042 denotes Id4
T444 2619-2624 D055418 denotes BMP-6
T445 2619-2624 D055418 denotes BMP-6
T446 2619-2624 Q04906 denotes BMP-6
T447 2619-2624 PR:000000167 denotes BMP-6
T448 2619-2624 P20722 denotes BMP-6
T449 2619-2624 PR:Q04906 denotes BMP-6
T450 2619-2624 P22004 denotes BMP-6
T451 2619-2624 PR:P22004 denotes BMP-6
T452 2619-2624 PR:P20722 denotes BMP-6