PMC:1134658 / 116-1401 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1134658","sourcedb":"PMC","sourceid":"1134658","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1134658","text":"Background\nBone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and are secreted proteins with pleiotropic roles in many different cell types. A potential role of BMP-6 in the immune system has been implied by various studies of malignant and rheumatoid diseases. In the present study, we explored the role of BMP-6 in normal human peripheral blood B cells.\n\nResults\nThe B cells were found to express BMP type I and type II receptors and BMP-6 rapidly induced phosphorylation of Smad1/5/8. Furthermore, Smad-phosphorylation was followed by upregulation of Id1 mRNA and Id1 protein, whereas Id2 and Id3 expression was not affected. 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