> top > docs > PMC:1064895 > spans > 21993-28087 > annotations

PMC:1064895 / 21993-28087 JSONTXT

Annnotations TAB JSON ListView MergeView

test3

Id Subject Object Predicate Lexical cue
T17221 6003-6008 Protein denotes IL-17
T17220 5922-5927 Protein denotes IL-17
T17219 5815-5823 Entity denotes promoter
T17218 5809-5814 Protein denotes IL-17
T17217 5785-5792 Binding denotes binding
T17216 5701-5706 Protein denotes IL-17
T17215 5685-5697 Positive_regulation denotes upregulation
T17214 5610-5613 Protein denotes Akt
T17213 5561-5568 Negative_regulation denotes lacking
T17212 5551-5556 Protein denotes IL-17
T17211 5542-5550 Positive_regulation denotes inducing
T17210 5427-5438 Binding denotes association
T17209 5420-5423 Protein denotes Akt
T17208 5229-5233 Protein denotes AP-1
T17207 5194-5199 Protein denotes IL-17
T17206 5181-5190 Positive_regulation denotes induction
T17205 5069-5074 Protein denotes IL-15
T17204 5063-5067 Protein denotes CD28
T17203 5036-5045 Positive_regulation denotes activated
T17202 4983-4988 Protein denotes IL-17
T17201 4970-4979 Positive_regulation denotes induction
T17200 4880-4894 Phosphorylation denotes phosphorylated
T17199 4873-4876 Protein denotes Akt
T17198 4830-4834 Negative_regulation denotes loss
T17197 4795-4805 Positive_regulation denotes activation
T17196 4791-4794 Protein denotes Akt
T17195 4656-4666 Gene_expression denotes production
T17194 4650-4655 Protein denotes IL-17
T17193 4494-4503 Negative_regulation denotes decreased
T17192 4473-4480 Binding denotes binding
T17191 4356-4376 Protein denotes CREB-binding protein
T17190 4351-4355 Protein denotes p300
T17189 4243-4252 Positive_regulation denotes activated
T17188 4227-4239 Protein denotes IκB kinase-β
T17187 4117-4126 Negative_regulation denotes inhibitor
T17186 4063-4076 Negative_regulation denotes downregulated
T17185 4048-4058 Gene_expression denotes production
T17184 4042-4047 Protein denotes IL-17
T17183 4034-4041 Positive_regulation denotes induced
T17182 3875-3883 Negative_regulation denotes hampered
T17181 3835-3845 Gene_expression denotes production
T17180 3829-3834 Protein denotes IL-17
T17179 3821-3828 Positive_regulation denotes induced
T17178 3817-3820 Protein denotes CD3
T17177 3775-3780 Protein denotes IL-17
T17176 3762-3771 Positive_regulation denotes induction
T17175 3746-3754 Regulation denotes involved
T17174 3607-3616 Regulation denotes regulated
T17173 3589-3599 Gene_expression denotes production
T17172 3583-3588 Protein denotes IL-17
T17171 3504-3509 Protein denotes IL-17
T17170 3406-3415 Positive_regulation denotes induction
T17169 3400-3405 Protein denotes IL-17
T17168 3390-3399 Positive_regulation denotes increases
T17167 3380-3384 Protein denotes CD28
T17166 3146-3151 Protein denotes MCP-1
T17165 3087-3092 Protein denotes TNF-α
T17164 3063-3073 Gene_expression denotes production
T17163 3057-3062 Protein denotes IL-17
T17162 3038-3047 Positive_regulation denotes triggered
T17161 3032-3037 Protein denotes IL-15
T17160 2969-2979 Gene_expression denotes production
T17159 2963-2968 Protein denotes IL-17
T17158 2956-2962 Regulation denotes affect
T17157 2924-2933 Positive_regulation denotes increased
T17156 2856-2861 Protein denotes TNF-α
T17155 2847-2851 Protein denotes IL-1
T17154 2808-2818 Gene_expression denotes production
T17153 2802-2807 Protein denotes IL-17
T17152 2792-2801 Positive_regulation denotes augmented
T17151 2770-2775 Protein denotes MCP-1
T17150 2761-2766 Protein denotes IL-15
T17149 2736-2741 Protein denotes IL-17
T17148 2722-2732 Gene_expression denotes production
T17147 2708-2717 Positive_regulation denotes increased
T17146 2664-2669 Protein denotes MCP-1
T17145 2654-2659 Protein denotes IL-15
T17144 2618-2622 Protein denotes CD28
T17143 2478-2483 Protein denotes IL-17
T17142 2464-2474 Gene_expression denotes production
T17141 2405-2415 Gene_expression denotes production
T17140 2399-2404 Protein denotes IL-17
T17139 2390-2398 Regulation denotes regulate
T17130 2058-2063 Protein denotes IL-17
T17129 1777-1786 Positive_regulation denotes augmented
T17128 1748-1758 Gene_expression denotes production
T17127 1742-1747 Protein denotes IL-17
T17126 1659-1664 Protein denotes IL-23
T17125 1639-1642 Protein denotes CD8
T17124 1627-1635 Gene_expression denotes produced
T17123 1531-1534 Protein denotes CD4
T17122 1502-1510 Gene_expression denotes produced
T17121 1493-1498 Protein denotes IL-17
T17120 1419-1422 Positive_regulation denotes due
T17119 1404-1409 Protein denotes IL-17
T17118 1388-1400 Positive_regulation denotes upregulation
T17117 1302-1311 Regulation denotes dependent
T17116 1268-1278 Gene_expression denotes production
T17115 1262-1267 Protein denotes IL-17
T17114 1252-1261 Positive_regulation denotes increased
T17113 1204-1208 Protein denotes CD28
T17112 1162-1165 Protein denotes PHA
T17111 1096-1100 Protein denotes CD28
T17110 1052-1062 Gene_expression denotes production
T17109 1046-1051 Protein denotes IL-17
T17108 998-1008 Gene_expression denotes production
T17107 992-997 Protein denotes IL-17
T17106 982-991 Positive_regulation denotes stimulate
T17105 842-847 Protein denotes IL-17
T17104 773-782 Regulation denotes regulated
T17103 759-769 Gene_expression denotes production
T17102 753-758 Protein denotes IL-17
T17101 601-606 Protein denotes IL-17
T17100 356-368 Protein denotes interferon-γ
T17099 347-351 Protein denotes IL-4
T17098 255-260 Protein denotes TNF-α
T17097 246-250 Protein denotes IL-1
T17096 11-16 Protein denotes IL-17
T17095 6003-6008 Protein denotes IL-17
T17094 5922-5927 Protein denotes IL-17
T17093 5809-5814 Protein denotes IL-17
T17092 5701-5706 Protein denotes IL-17
T17091 5610-5613 Protein denotes Akt
T17090 5551-5556 Protein denotes IL-17
T17089 5420-5423 Protein denotes Akt
T17088 5229-5233 Protein denotes AP-1
T17087 5194-5199 Protein denotes IL-17
T17086 5069-5074 Protein denotes IL-15
T17085 5063-5067 Protein denotes CD28
T17084 4983-4988 Protein denotes IL-17
T17083 4873-4876 Protein denotes Akt
T17082 4791-4794 Protein denotes Akt
T17081 4650-4655 Protein denotes IL-17
T17080 4356-4376 Protein denotes CREB-binding protein
T17079 4351-4355 Protein denotes p300
T17078 4227-4239 Protein denotes IκB kinase-β
T17077 4042-4047 Protein denotes IL-17
T17076 3829-3834 Protein denotes IL-17
T17075 3817-3820 Protein denotes CD3
T17074 3775-3780 Protein denotes IL-17
T17073 3583-3588 Protein denotes IL-17
T17072 3504-3509 Protein denotes IL-17
T17071 3400-3405 Protein denotes IL-17
T17070 3380-3384 Protein denotes CD28
T17069 3146-3151 Protein denotes MCP-1
T17068 3087-3092 Protein denotes TNF-α
T17067 3057-3062 Protein denotes IL-17
T17066 3032-3037 Protein denotes IL-15
T17065 2963-2968 Protein denotes IL-17
T17064 2856-2861 Protein denotes TNF-α
T17063 2847-2851 Protein denotes IL-1
T17062 2802-2807 Protein denotes IL-17
T17061 2770-2775 Protein denotes MCP-1
T17060 2761-2766 Protein denotes IL-15
T17059 2736-2741 Protein denotes IL-17
T17058 2664-2669 Protein denotes MCP-1
T17057 2654-2659 Protein denotes IL-15
T17056 2618-2622 Protein denotes CD28
T17055 2478-2483 Protein denotes IL-17
T17054 2399-2404 Protein denotes IL-17
T17053 2364-2369 Protein denotes IL-23
T17052 2354-2359 Protein denotes IL-15
T17051 2305-2310 Protein denotes IL-17
T17050 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T17049 2142-2146 Protein denotes IL-8
T17048 2136-2140 Protein denotes IL-6
T17047 2058-2063 Protein denotes IL-17
T17046 1742-1747 Protein denotes IL-17
T17045 1659-1664 Protein denotes IL-23
T17044 1639-1642 Protein denotes CD8
T17043 1531-1534 Protein denotes CD4
T17042 1493-1498 Protein denotes IL-17
T17041 1404-1409 Protein denotes IL-17
T17040 1262-1267 Protein denotes IL-17
T17039 1204-1208 Protein denotes CD28
T17038 1162-1165 Protein denotes PHA
T17037 1096-1100 Protein denotes CD28
T17036 1046-1051 Protein denotes IL-17
T17035 992-997 Protein denotes IL-17
T17034 842-847 Protein denotes IL-17
T17033 753-758 Protein denotes IL-17
T17032 601-606 Protein denotes IL-17
T17031 356-368 Protein denotes interferon-γ
T17030 347-351 Protein denotes IL-4
T17029 255-260 Protein denotes TNF-α
T17028 246-250 Protein denotes IL-1
T17027 11-16 Protein denotes IL-17
T17138 2364-2369 Protein denotes IL-23
T17137 2354-2359 Protein denotes IL-15
T17136 2311-2321 Gene_expression denotes production
T17135 2305-2310 Protein denotes IL-17
T17134 2295-2304 Positive_regulation denotes stimulate
T17133 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T17132 2142-2146 Protein denotes IL-8
T17131 2136-2140 Protein denotes IL-6
R9267 T17102 T17103 themeOf IL-17,production
R9268 T17103 T17104 themeOf production,regulated
R9269 T17107 T17108 themeOf IL-17,production
R9270 T17108 T17106 themeOf production,stimulate
R9271 T17109 T17110 themeOf IL-17,production
R9272 T17110 T17106 themeOf production,stimulate
R9273 T17112 T17114 causeOf PHA,increased
R9274 T17114 T17117 themeOf increased,dependent
R9275 T17115 T17116 themeOf IL-17,production
R9276 T17116 T17114 themeOf production,increased
R9277 T17116 T17117 themeOf production,dependent
R9278 T17118 T17120 themeOf upregulation,due
R9279 T17119 T17118 themeOf IL-17,upregulation
R9280 T17121 T17122 themeOf IL-17,produced
R9281 T17127 T17128 themeOf IL-17,production
R9282 T17128 T17129 themeOf production,augmented
R9283 T17135 T17136 themeOf IL-17,production
R9284 T17136 T17134 themeOf production,stimulate
R9285 T17138 T17134 causeOf IL-23,stimulate
R9286 T17140 T17141 themeOf IL-17,production
R9287 T17141 T17139 themeOf production,regulate
R9288 T17143 T17142 themeOf IL-17,production
R9289 T17148 T17147 themeOf production,increased
R9290 T17149 T17148 themeOf IL-17,production
R9291 T17153 T17154 themeOf IL-17,production
R9292 T17154 T17152 themeOf production,augmented
R9293 T17155 T17158 causeOf IL-1,affect
R9294 T17159 T17160 themeOf IL-17,production
R9295 T17160 T17158 themeOf production,affect
R9296 T17161 T17162 causeOf IL-15,triggered
R9297 T17163 T17164 themeOf IL-17,production
R9298 T17164 T17162 themeOf production,triggered
R9299 T17169 T17170 themeOf IL-17,induction
R9300 T17170 T17168 themeOf induction,increases
R9301 T17172 T17173 themeOf IL-17,production
R9302 T17173 T17174 themeOf production,regulated
R9303 T17176 T17175 themeOf induction,involved
R9304 T17177 T17176 themeOf IL-17,induction
R9305 T17178 T17179 causeOf CD3,induced
R9306 T17179 T17182 themeOf induced,hampered
R9307 T17180 T17181 themeOf IL-17,production
R9308 T17181 T17182 themeOf production,hampered
R9309 T17181 T17179 themeOf production,induced
R9310 T17183 T17186 themeOf induced,downregulated
R9311 T17184 T17185 themeOf IL-17,production
R9312 T17185 T17186 themeOf production,downregulated
R9313 T17185 T17183 themeOf production,induced
R9314 T17187 T17186 causeOf inhibitor,downregulated
R9315 T17188 T17189 themeOf IκB kinase-β,activated
R9316 T17192 T17193 themeOf binding,decreased
R9317 T17194 T17195 themeOf IL-17,production
R9318 T17196 T17197 themeOf Akt,activation
R9319 T17199 T17200 themeOf Akt,phosphorylated
R9320 T17202 T17201 themeOf IL-17,induction
R9321 T17207 T17206 themeOf IL-17,induction
R9322 T17209 T17210 themeOf Akt,association
R9323 T17212 T17213 themeOf IL-17,lacking
R9324 T17216 T17215 themeOf IL-17,upregulation
R9325 T17219 T17218 partOf promoter,IL-17
R9326 T17219 T17217 themeOf promoter,binding

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T20163 5904-5913 Positive_regulation denotes induction
T20162 5685-5697 Positive_regulation denotes upregulation
T20161 5427-5438 Binding denotes association
T20160 5561-5568 Negative_regulation denotes lacking
T20159 5181-5190 Positive_regulation denotes induction
T20158 5165-5173 Regulation denotes involved
T20157 4880-4894 Phosphorylation denotes phosphorylated
T20156 4970-4979 Positive_regulation denotes induction
T20155 4943-4954 Regulation denotes involvement
T20154 4795-4805 Positive_regulation denotes activation
T20153 4779-4787 Regulation denotes response
T20152 4656-4666 Gene_expression denotes production
T20151 4323-4332 Positive_regulation denotes involving
T20150 4243-4252 Positive_regulation denotes activated
T20149 4025-4041 Positive_regulation denotes anti-CD3-induced
T20148 4048-4058 Gene_expression denotes production
T20147 4063-4076 Negative_regulation denotes downregulated
T20146 3821-3828 Positive_regulation denotes induced
T20145 3835-3845 Gene_expression denotes production
T20144 3875-3883 Negative_regulation denotes hampered
T20143 3762-3771 Positive_regulation denotes induction
T20142 3746-3754 Regulation denotes involved
T20132 2924-2933 Positive_regulation denotes increased
T20131 2792-2801 Positive_regulation denotes augmented
T20130 2754-2760 Positive_regulation denotes Adding
T20129 2808-2818 Gene_expression denotes production
T20128 2708-2717 Positive_regulation denotes increased
T20127 2685-2693 Binding denotes ligation
T20126 2722-2732 Gene_expression denotes production
T20125 2464-2474 Gene_expression denotes production
T20124 2390-2398 Regulation denotes regulate
T20123 2295-2304 Positive_regulation denotes stimulate
T20122 2311-2321 Gene_expression denotes production
T20121 2405-2415 Gene_expression denotes production
T20120 2102-2109 Localization denotes secrete
T20119 1777-1786 Positive_regulation denotes augmented
T20118 1748-1758 Gene_expression denotes production
T20117 1502-1510 Gene_expression denotes produced
T20116 1388-1400 Positive_regulation denotes upregulation
T20115 1252-1261 Positive_regulation denotes increased
T20114 1268-1278 Gene_expression denotes production
T20113 1052-1062 Gene_expression denotes production
T20112 982-991 Positive_regulation denotes stimulate
T20111 998-1008 Gene_expression denotes production
T20110 773-782 Regulation denotes regulated
T20109 759-769 Gene_expression denotes production
T20108 6003-6008 Protein denotes IL-17
T20107 5922-5927 Protein denotes IL-17
T20106 5809-5814 Protein denotes IL-17
T20105 5701-5706 Protein denotes IL-17
T20104 5610-5613 Protein denotes Akt
T20103 5551-5556 Protein denotes IL-17
T20102 5420-5423 Protein denotes Akt
T20101 5229-5233 Protein denotes AP-1
T20100 5194-5199 Protein denotes IL-17
T20099 5069-5074 Protein denotes IL-15
T20098 5063-5067 Protein denotes CD28
T20097 4983-4988 Protein denotes IL-17
T20096 4873-4876 Protein denotes Akt
T20095 4791-4794 Protein denotes Akt
T20094 4650-4655 Protein denotes IL-17
T20093 4356-4376 Protein denotes CREB-binding protein
T20092 4351-4355 Protein denotes p300
T20091 4227-4239 Protein denotes IκB kinase-β
T20090 4042-4047 Protein denotes IL-17
T20089 3829-3834 Protein denotes IL-17
T20088 3817-3820 Protein denotes CD3
T20087 3775-3780 Protein denotes IL-17
T20086 3583-3588 Protein denotes IL-17
T20085 3504-3509 Protein denotes IL-17
T20084 3400-3405 Protein denotes IL-17
T20083 3380-3384 Protein denotes CD28
T20082 3146-3151 Protein denotes MCP-1
T20081 3087-3092 Protein denotes TNF-α
T20080 3057-3062 Protein denotes IL-17
T20079 3032-3037 Protein denotes IL-15
T20078 2963-2968 Protein denotes IL-17
T20077 2856-2861 Protein denotes TNF-α
T20076 2847-2851 Protein denotes IL-1
T20075 2802-2807 Protein denotes IL-17
T20074 2770-2775 Protein denotes MCP-1
T20073 2761-2766 Protein denotes IL-15
T20072 2736-2741 Protein denotes IL-17
T20071 2664-2669 Protein denotes MCP-1
T20070 2654-2659 Protein denotes IL-15
T20069 2618-2622 Protein denotes CD28
T20068 2478-2483 Protein denotes IL-17
T20067 2399-2404 Protein denotes IL-17
T20066 2364-2369 Protein denotes IL-23
T20065 2354-2359 Protein denotes IL-15
T20064 2305-2310 Protein denotes IL-17
T20063 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T20062 2142-2146 Protein denotes IL-8
T20061 2136-2140 Protein denotes IL-6
T20060 2058-2063 Protein denotes IL-17
T20059 1742-1747 Protein denotes IL-17
T20058 1659-1664 Protein denotes IL-23
T20057 1639-1642 Protein denotes CD8
T20056 1531-1534 Protein denotes CD4
T20055 1493-1498 Protein denotes IL-17
T20054 1404-1409 Protein denotes IL-17
T20053 1262-1267 Protein denotes IL-17
T20052 1204-1208 Protein denotes CD28
T20051 1162-1165 Protein denotes PHA
T20050 992-997 Protein denotes IL-17
T20049 1096-1100 Protein denotes CD28
T20048 1046-1051 Protein denotes IL-17
T20047 842-847 Protein denotes IL-17
T20046 753-758 Protein denotes IL-17
T20045 601-606 Protein denotes IL-17
T20044 356-368 Protein denotes interferon-γ
T20043 347-351 Protein denotes IL-4
T20042 255-260 Protein denotes TNF-α
T20041 246-250 Protein denotes IL-1
T20040 11-16 Protein denotes IL-17
T20141 3607-3616 Regulation denotes regulated
T20140 3589-3599 Gene_expression denotes production
T20139 3390-3399 Positive_regulation denotes increases
T20138 3406-3415 Positive_regulation denotes induction
T20137 3161-3168 Positive_regulation denotes induces
T20136 3063-3073 Gene_expression denotes production
T20135 3038-3047 Positive_regulation denotes triggered
T20134 2956-2962 Regulation denotes affect
T20133 2969-2979 Gene_expression denotes production
R10594 T20046 T20109 themeOf IL-17,production
R10595 T20048 T20113 themeOf IL-17,production
R10596 T20050 T20111 themeOf IL-17,production
R10597 T20051 T20115 causeOf PHA,increased
R10598 T20053 T20114 themeOf IL-17,production
R10599 T20054 T20116 themeOf IL-17,upregulation
R10600 T20055 T20117 themeOf IL-17,produced
R10601 T20059 T20118 themeOf IL-17,production
R10602 T20061 T20120 themeOf IL-6,secrete
R10603 T20062 T20120 themeOf IL-8,secrete
R10604 T20063 T20120 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10605 T20064 T20122 themeOf IL-17,production
R10606 T20067 T20121 themeOf IL-17,production
R10607 T20068 T20125 themeOf IL-17,production
R10608 T20070 T20127 themeOf IL-15,ligation
R10609 T20070 T20128 causeOf IL-15,increased
R10610 T20071 T20127 themeOf MCP-1,ligation
R10611 T20071 T20128 causeOf MCP-1,increased
R10612 T20072 T20126 themeOf IL-17,production
R10613 T20073 T20130 themeOf IL-15,Adding
R10614 T20074 T20130 themeOf MCP-1,Adding
R10615 T20075 T20129 themeOf IL-17,production
R10616 T20076 T20132 themeOf IL-1,increased
R10617 T20076 T20134 causeOf IL-1,affect
R10618 T20078 T20133 themeOf IL-17,production
R10619 T20079 T20135 causeOf IL-15,triggered
R10620 T20080 T20136 themeOf IL-17,production
R10621 T20082 T20137 themeOf MCP-1,induces
R10622 T20084 T20138 themeOf IL-17,induction
R10623 T20086 T20140 themeOf IL-17,production
R10624 T20087 T20143 themeOf IL-17,induction
R10625 T20089 T20145 themeOf IL-17,production
R10626 T20090 T20148 themeOf IL-17,production
R10627 T20091 T20150 themeOf IκB kinase-β,activated
R10628 T20092 T20151 themeOf p300,involving
R10629 T20094 T20152 themeOf IL-17,production
R10630 T20095 T20154 themeOf Akt,activation
R10631 T20096 T20157 themeOf Akt,phosphorylated
R10632 T20097 T20156 themeOf IL-17,induction
R10633 T20100 T20159 themeOf IL-17,induction
R10634 T20102 T20161 themeOf Akt,association
R10635 T20103 T20160 themeOf IL-17,lacking
R10636 T20105 T20162 themeOf IL-17,upregulation
R10637 T20107 T20163 themeOf IL-17,induction
R10638 T20109 T20110 themeOf production,regulated
R10639 T20111 T20112 themeOf production,stimulate
R10640 T20114 T20115 themeOf production,increased
R10641 T20118 T20119 themeOf production,augmented
R10642 T20121 T20124 themeOf production,regulate
R10643 T20122 T20123 themeOf production,stimulate
R10644 T20126 T20128 themeOf production,increased
R10645 T20126 T20128 themeOf production,increased
R10646 T20126 T20128 themeOf production,increased
R10647 T20126 T20128 themeOf production,increased
R10648 T20127 T20128 causeOf ligation,increased
R10649 T20127 T20128 causeOf ligation,increased
R10650 T20129 T20131 themeOf production,augmented
R10651 T20133 T20134 themeOf production,affect
R10652 T20136 T20135 themeOf production,triggered
R10653 T20138 T20139 themeOf induction,increases
R10654 T20140 T20141 themeOf production,regulated
R10655 T20143 T20142 themeOf induction,involved
R10656 T20145 T20144 themeOf production,hampered
R10657 T20145 T20146 themeOf production,induced
R10658 T20148 T20149 themeOf production,anti-CD3-induced
R10659 T20148 T20147 themeOf production,downregulated
R10660 T20154 T20153 themeOf activation,response
R10661 T20156 T20155 themeOf induction,involvement
R10662 T20159 T20158 themeOf induction,involved

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T21980 5904-5913 Positive_regulation denotes induction
T21979 5685-5697 Positive_regulation denotes upregulation
T21978 5767-5775 Negative_regulation denotes blocking
T21977 5561-5568 Negative_regulation denotes lacking
T21976 5181-5190 Positive_regulation denotes induction
T21975 4880-4894 Phosphorylation denotes phosphorylated
T21974 4943-4954 Regulation denotes involvement
T21973 4970-4979 Positive_regulation denotes induction
T21972 4795-4805 Positive_regulation denotes activation
T21971 4656-4666 Gene_expression denotes production
T21970 4243-4252 Positive_regulation denotes activated
T21969 4048-4058 Gene_expression denotes production
T21968 4063-4076 Negative_regulation denotes downregulated
T21967 4025-4041 Positive_regulation denotes anti-CD3-induced
T21966 3821-3828 Positive_regulation denotes induced
T21965 3835-3845 Gene_expression denotes production
T21964 3762-3771 Positive_regulation denotes induction
T21963 3589-3599 Gene_expression denotes production
T21962 3607-3616 Regulation denotes regulated
T21961 3390-3399 Positive_regulation denotes increases
T21960 3406-3415 Positive_regulation denotes induction
T21959 3038-3047 Positive_regulation denotes triggered
T21958 3063-3073 Gene_expression denotes production
T21957 2956-2962 Regulation denotes affect
T21956 2969-2979 Gene_expression denotes production
T21955 2754-2760 Positive_regulation denotes Adding
T21954 2808-2818 Gene_expression denotes production
T21953 2792-2801 Positive_regulation denotes augmented
T21952 2685-2693 Binding denotes ligation
T21951 2708-2717 Positive_regulation denotes increased
T21950 2722-2732 Gene_expression denotes production
T21949 2464-2474 Gene_expression denotes production
T21948 2390-2398 Regulation denotes regulate
T21947 2311-2321 Gene_expression denotes production
T21946 2295-2304 Positive_regulation denotes stimulate
T21945 2405-2415 Gene_expression denotes production
T21944 2102-2109 Localization denotes secrete
T21943 1748-1758 Gene_expression denotes production
T21942 1777-1786 Positive_regulation denotes augmented
T21941 1502-1510 Gene_expression denotes produced
T21940 1388-1400 Positive_regulation denotes upregulation
T21939 1268-1278 Gene_expression denotes production
T21938 1252-1261 Positive_regulation denotes increased
T21937 982-991 Positive_regulation denotes stimulate
T21936 1052-1062 Gene_expression denotes production
T21935 998-1008 Gene_expression denotes production
T21934 773-782 Regulation denotes regulated
T21933 759-769 Gene_expression denotes production
T21932 6003-6008 Protein denotes IL-17
T21931 5922-5927 Protein denotes IL-17
T21930 5809-5814 Protein denotes IL-17
T21929 5701-5706 Protein denotes IL-17
T21928 5610-5613 Protein denotes Akt
T21927 5551-5556 Protein denotes IL-17
T21926 5420-5423 Protein denotes Akt
T21925 5229-5233 Protein denotes AP-1
T21924 5194-5199 Protein denotes IL-17
T21923 5069-5074 Protein denotes IL-15
T21922 5063-5067 Protein denotes CD28
T21921 4983-4988 Protein denotes IL-17
T21920 4873-4876 Protein denotes Akt
T21919 4791-4794 Protein denotes Akt
T21918 4650-4655 Protein denotes IL-17
T21917 4356-4376 Protein denotes CREB-binding protein
T21916 4351-4355 Protein denotes p300
T21915 4227-4239 Protein denotes IκB kinase-β
T21914 4042-4047 Protein denotes IL-17
T21913 3829-3834 Protein denotes IL-17
T21912 3817-3820 Protein denotes CD3
T21911 3775-3780 Protein denotes IL-17
T21910 3583-3588 Protein denotes IL-17
T21909 3504-3509 Protein denotes IL-17
T21908 3400-3405 Protein denotes IL-17
T21907 3380-3384 Protein denotes CD28
T21906 3146-3151 Protein denotes MCP-1
T21905 3087-3092 Protein denotes TNF-α
T21904 3057-3062 Protein denotes IL-17
T21903 3032-3037 Protein denotes IL-15
T21902 2963-2968 Protein denotes IL-17
T21901 2856-2861 Protein denotes TNF-α
T21900 2847-2851 Protein denotes IL-1
T21899 2802-2807 Protein denotes IL-17
T21898 2770-2775 Protein denotes MCP-1
T21897 2761-2766 Protein denotes IL-15
T21896 2736-2741 Protein denotes IL-17
T21895 2664-2669 Protein denotes MCP-1
T21894 2654-2659 Protein denotes IL-15
T21893 2618-2622 Protein denotes CD28
T21892 2478-2483 Protein denotes IL-17
T21891 2399-2404 Protein denotes IL-17
T21890 2364-2369 Protein denotes IL-23
T21889 2354-2359 Protein denotes IL-15
T21888 2305-2310 Protein denotes IL-17
T21887 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T21886 2142-2146 Protein denotes IL-8
T21885 2136-2140 Protein denotes IL-6
T21884 2058-2063 Protein denotes IL-17
T21883 1742-1747 Protein denotes IL-17
T21882 1659-1664 Protein denotes IL-23
T21881 1639-1642 Protein denotes CD8
T21880 1531-1534 Protein denotes CD4
T21879 1493-1498 Protein denotes IL-17
T21878 1404-1409 Protein denotes IL-17
T21877 1262-1267 Protein denotes IL-17
T21876 1204-1208 Protein denotes CD28
T21875 1162-1165 Protein denotes PHA
T21874 992-997 Protein denotes IL-17
T21873 1096-1100 Protein denotes CD28
T21872 1046-1051 Protein denotes IL-17
T21871 842-847 Protein denotes IL-17
T21870 753-758 Protein denotes IL-17
T21869 601-606 Protein denotes IL-17
T21868 356-368 Protein denotes interferon-γ
T21867 347-351 Protein denotes IL-4
T21866 255-260 Protein denotes TNF-α
T21865 246-250 Protein denotes IL-1
T21864 11-16 Protein denotes IL-17
R11996 T21935 T21937 themeOf production,stimulate
R11997 T21870 T21933 themeOf IL-17,production
R11998 T21872 T21936 themeOf IL-17,production
R11999 T21939 T21938 themeOf production,increased
R12000 T21874 T21935 themeOf IL-17,production
R12001 T21877 T21939 themeOf IL-17,production
R12002 T21878 T21940 themeOf IL-17,upregulation
R12003 T21943 T21942 themeOf production,augmented
R12004 T21879 T21941 themeOf IL-17,produced
R12005 T21945 T21948 themeOf production,regulate
R12006 T21883 T21943 themeOf IL-17,production
R12007 T21885 T21944 themeOf IL-6,secrete
R12008 T21945 T21948 themeOf production,regulate
R12009 T21886 T21944 themeOf IL-8,secrete
R12010 T21947 T21946 themeOf production,stimulate
R12011 T21887 T21944 themeOf tumor necrosis factor-stimulated gene 6,secrete
R12012 T21888 T21947 themeOf IL-17,production
R12013 T21889 T21948 causeOf IL-15,regulate
R12014 T21950 T21951 themeOf production,increased
R12015 T21890 T21948 causeOf IL-23,regulate
R12016 T21891 T21945 themeOf IL-17,production
R12017 T21892 T21949 themeOf IL-17,production
R12018 T21954 T21953 themeOf production,augmented
R12019 T21895 T21952 themeOf MCP-1,ligation
R12020 T21895 T21951 causeOf MCP-1,increased
R12021 T21896 T21950 themeOf IL-17,production
R12022 T21897 T21955 themeOf IL-15,Adding
R12023 T21898 T21955 themeOf MCP-1,Adding
R12024 T21899 T21954 themeOf IL-17,production
R12025 T21900 T21957 causeOf IL-1,affect
R12026 T21901 T21957 causeOf TNF-α,affect
R12027 T21954 T21953 themeOf production,augmented
R12028 T21902 T21956 themeOf IL-17,production
R12029 T21904 T21958 themeOf IL-17,production
R12030 T21955 T21953 causeOf Adding,augmented
R12031 T21955 T21953 causeOf Adding,augmented
R12032 T21908 T21960 themeOf IL-17,induction
R12033 T21956 T21957 themeOf production,affect
R12034 T21910 T21963 themeOf IL-17,production
R12035 T21911 T21964 themeOf IL-17,induction
R12036 T21956 T21957 themeOf production,affect
R12037 T21913 T21965 themeOf IL-17,production
R12038 T21958 T21959 themeOf production,triggered
R12039 T21914 T21969 themeOf IL-17,production
R12040 T21915 T21970 themeOf IκB kinase-β,activated
R12041 T21960 T21961 themeOf induction,increases
R12042 T21918 T21971 themeOf IL-17,production
R12043 T21919 T21972 themeOf Akt,activation
R12044 T21920 T21975 themeOf Akt,phosphorylated
R12045 T21963 T21962 themeOf production,regulated
R12046 T21921 T21973 themeOf IL-17,induction
R12047 T21924 T21976 themeOf IL-17,induction
R12048 T21965 T21966 themeOf production,induced
R12049 T21927 T21977 themeOf IL-17,lacking
R12050 T21969 T21967 themeOf production,anti-CD3-induced
R12051 T21929 T21979 themeOf IL-17,upregulation
R12052 T21930 T21978 themeOf IL-17,blocking
R12053 T21931 T21980 themeOf IL-17,induction
R12054 T21933 T21934 themeOf production,regulated
R12055 T21969 T21968 themeOf production,downregulated
R12056 T21973 T21974 themeOf induction,involvement

2_test

Id Subject Object Predicate Lexical cue
15642134-8676080-4202028 90-91 8676080 denotes 5
15642134-7499828-4202029 92-94 7499828 denotes 22
15642134-2271017-4202030 207-209 2271017 denotes 23
15642134-2109776-4202031 424-426 2109776 denotes 24
15642134-12677240-4202032 920-922 12677240 denotes 15
15642134-11012616-4202033 1137-1139 11012616 denotes 25
15642134-9973376-4202034 1598-1600 9973376 denotes 26
15642134-12707317-4202035 1724-1726 12707317 denotes 14
15642134-11441109-4202036 1866-1868 11441109 denotes 27
15642134-10323452-4202037 2229-2231 10323452 denotes 12
15642134-11160281-4202038 2232-2234 11160281 denotes 28
15642134-12823853-4202039 2235-2237 12823853 denotes 29
15642134-10679127-4202040 2417-2419 10679127 denotes 13
15642134-12707317-4202041 2420-2422 12707317 denotes 14
15642134-10679127-4202042 3108-3110 10679127 denotes 13
15642134-11012616-4202043 3335-3337 11012616 denotes 25
15642134-9182915-4202044 3538-3539 9182915 denotes 8
15642134-11966773-4202045 3540-3542 11966773 denotes 30
15642134-10817568-4202046 3543-3545 10817568 denotes 31
15642134-10781614-4202047 4261-4263 10781614 denotes 32
15642134-11259436-4202048 4378-4380 11259436 denotes 33
15642134-12810200-4202049 5973-5974 12810200 denotes 2
15642134-12632409-4202050 5975-5976 12632409 denotes 6
15642134-10880256-4202051 5977-5979 10880256 denotes 34
15642134-14872510-4202051 5977-5979 14872510 denotes 34
15642134-11920418-4202051 5977-5979 11920418 denotes 34

biosemtest

Id Subject Object Predicate Lexical cue
T17696 2153-2174 UP/P48094 denotes mor necrosis factor-s
T18051 2153-2174 UP/P23563 denotes mor necrosis factor-s
T18134 1385-1389 UMLS/C0323983 denotes is u
T18133 589-593 UMLS/C0323983 denotes is r
T18132 2943-2949 UMLS/C0444497 denotes nts, d
T18131 2039-2045 UMLS/C0444497 denotes ints.
T18130 1924-1930 UMLS/C0444497 denotes ints m
T18129 4642-4645 UP/Q01552 denotes -κB
T18128 4292-4295 UP/Q01552 denotes sti
T18127 4264-4267 UP/Q01552 denotes , a
T18126 4215-4218 UP/Q01552 denotes n m
T18125 4642-4645 UP/O95433 denotes -κB
T18124 4292-4295 UP/O95433 denotes sti
T18123 4264-4267 UP/O95433 denotes , a
T18122 4215-4218 UP/O95433 denotes n m
T18121 3979-3989 UMLS/C1548180 denotes ction with
T18120 2724-2734 UMLS/C1548180 denotes oduction o
T18119 2466-2476 UMLS/C1548180 denotes oduction o
T18118 4661-4677 UMLS/C1819444 denotes ction needs to b
T18117 4047-4063 UMLS/C1819444 denotes production was
T18116 3833-3849 UMLS/C1819444 denotes 7 production in
T18115 3587-3603 UMLS/C1819444 denotes 7 production can
T18114 3060-3076 UMLS/C1819444 denotes 17 production in
T18113 2966-2982 UMLS/C1819444 denotes 17 production. O
T18112 2804-2820 UMLS/C1819444 denotes -17 production m
T18111 2401-2417 UMLS/C1819444 denotes -17 production [
T18110 2307-2323 UMLS/C1819444 denotes -17 production i
T18109 1744-1760 UMLS/C1819444 denotes -17 production w
T18108 1264-1280 UMLS/C1819444 denotes -17 production f
T18107 1048-1064 UMLS/C1819444 denotes -17 production c
T18106 994-1010 UMLS/C1819444 denotes -17 production i
T18105 755-771 UMLS/C1819444 denotes -17 production i
T18104 2153-2174 UP/P19101 denotes mor necrosis factor-s
T18103 3041-3050 UMLS/C0032930 denotes ggered in
T18102 1667-1677 UMLS/C0032930 denotes iggering m
T18101 2285-2291 UMLS/C1551364 denotes ents t
T18100 972-978 UMLS/C1551364 denotes ents t
T18099 1883-1894 UMLS/C1546938 denotes teraction b
T18098 3611-3620 UMLS/C0851285 denotes lated by
T18097 2392-2400 UMLS/C0851285 denotes gulate I
T18096 775-784 UMLS/C0851285 denotes gulated i
T18095 2153-2174 UP/O77764 denotes mor necrosis factor-s
T18094 4561-4569 UP/O62618 denotes athway i
T18093 4418-4426 UP/O62618 denotes activati
T18092 4113-4121 UP/O62618 denotes APK inhi
T18091 1861-1866 UMLS/C0026336 denotes del [
T18090 1861-1866 UMLS/C0026339 denotes del [
T18089 1299-1313 UMLS/C1512045 denotes se-dependent m
T18088 4177-4185 UMLS/C0344211 denotes rts cros
T18087 3273-3284 UMLS/C0024432 denotes ophages in
T18086 594-601 UMLS/C0679133 denotes spect,
T18085 5090-5098 UMLS/C0026249 denotes our expe
T18084 2549-2557 UMLS/C0026249 denotes togens a
T18083 1171-1179 UMLS/C0026249 denotes togens,
T18082 4642-4645 UP/Q63768 denotes -κB
T18081 4292-4295 UP/Q63768 denotes sti
T18080 4264-4267 UP/Q63768 denotes , a
T18079 4215-4218 UP/Q63768 denotes n m
T18078 5521-5531 UMLS/C0007634 denotes e data on
T18077 1903-1908 UMLS/C0007634 denotes lls i
T18076 1570-1575 UMLS/C0007634 denotes lls,
T18075 1438-1446 UMLS/C0007634 denotes llular a
T18074 5326-5336 UMLS/C0282554 denotes as not act
T18073 3494-3504 UMLS/C0282554 denotes okines by
T18072 2534-2544 UMLS/C0282554 denotes emokines a
T18071 1988-1998 UMLS/C0282554 denotes emokines,
T18070 2906-2916 UMLS/C1705419 denotes perties an
T18069 702-712 UMLS/C1705419 denotes operties.
T18068 78-88 UMLS/C1705419 denotes properties
T18067 2153-2174 UP/Q8JFG3 denotes mor necrosis factor-s
T18066 498-506 UMLS/C1550315 denotes novial i
T18065 2153-2174 UP/P59695 denotes mor necrosis factor-s
T18064 2153-2174 UP/Q06599 denotes mor necrosis factor-s
T18063 4701-4707 UMLS/C0016884 denotes riment
T18062 2153-2174 UP/O35734 denotes mor necrosis factor-s
T18061 5801-5808 UMLS/C0243122 denotes in the
T18060 4483-4490 UMLS/C0243122 denotes tivity
T18059 4678-4683 UMLS/C0027552 denotes stud
T18058 3263-3272 UMLS/C0026473 denotes cytes/mac
T18057 2366-2371 UMLS/C1881122 denotes -23)
T18056 1661-1666 UMLS/C1881122 denotes -23 t
T18055 4019-4024 UMLS/C0243095 denotes that
T18054 1325-1330 UMLS/C0243095 denotes und,
T18053 855-860 UMLS/C0243095 denotes und t
T18052 4404-4412 UMLS/C0443289 denotes that p38
T18050 2153-2174 UP/P29553 denotes mor necrosis factor-s
T18049 1691-1695 UMLS/C0439208 denotes am-n
T18048 6085-6093 UMLS/C1521840 denotes es in RA
T18047 2153-2174 UP/P13296 denotes mor necrosis factor-s
T18046 2285-2291 UMLS/C1521826 denotes ents t
T18045 972-978 UMLS/C1521826 denotes ents t
T18044 2906-2916 UMLS/C1882134 denotes perties an
T18043 702-712 UMLS/C1882134 denotes operties.
T18042 78-88 UMLS/C1882134 denotes properties
T18041 1875-1882 UMLS/C1704241 denotes mplex i
T18040 4422-4437 UMLS/C1155551 denotes vation was not
T18039 1356-1361 UMLS/C0005507 denotes say (
T18038 4578-4589 UMLS/C1608386 denotes t of PI3K a
T18037 4841-4845 UMLS/C1517945 denotes ivit
T18036 3319-3325 UMLS/C0439166 denotes al ind
T18035 5219-5223 UMLS/C1321301 denotes rast
T18034 3856-3860 UMLS/C1321301 denotes was
T18033 3791-3795 UMLS/C1321301 denotes . We
T18032 3426-3430 UMLS/C1321301 denotes . Al
T18031 3288-3292 UMLS/C1321301 denotes cul
T18030 3080-3084 UMLS/C1321301 denotes C, b
T18029 2750-2754 UMLS/C1321301 denotes MC.
T18028 2492-2496 UMLS/C1321301 denotes MC r
T18027 1289-1293 UMLS/C1321301 denotes MC i
T18026 791-795 UMLS/C1321301 denotes MC,
T18025 5894-5904 UMLS/C0439167 denotes uccessful
T18024 5809-5817 UMLS/C0439167 denotes IL-17 pr
T18023 4849-4857 UMLS/C0439167 denotes 2 hours
T18022 4491-4499 UMLS/C0439167 denotes as decre
T18021 1447-1455 UMLS/C0439167 denotes tivity r
T18020 5153-5160 UMLS/C1704259 denotes so acti
T18019 4749-4756 UMLS/C1704259 denotes PI3K se
T18018 4570-4577 UMLS/C1704259 denotes depende
T17869 1126-1137 UMLS/C1550471 denotes dividuals [
T17868 3779-3784 UMLS/C0384648 denotes 7 in
T17867 3508-3513 UMLS/C0384648 denotes 7 has
T17866 3404-3409 UMLS/C0384648 denotes 7 ind
T17865 2738-2743 UMLS/C0384648 denotes -17 i
T17864 2480-2485 UMLS/C0384648 denotes -17 i
T17863 4861-4868 UMLS/C1292425 denotes e fact
T17862 4177-4185 UMLS/C1317973 denotes rts cros
T17861 2060-2065 UMLS/C0384648 denotes -17 s
T17860 2204-2220 UMLS/C0012472 denotes ostaglandin E2 i
T17859 2153-2174 UP/Q2MH05 denotes mor necrosis factor-s
T17858 1903-1908 UMLS/C1948049 denotes lls i
T17857 1570-1575 UMLS/C1948049 denotes lls,
T17856 3934-3943 UMLS/C1999216 denotes itor PDTC
T17855 3900-3909 UMLS/C1999216 denotes bitor LY2
T17854 403-409 UMLS/C1511790 denotes tect i
T17853 1495-1500 UMLS/C0384648 denotes -17 i
T17852 2153-2174 UP/Q539C2 denotes mor necrosis factor-s
T17851 4396-4403 UMLS/C1280519 denotes evealed
T17850 5961-5970 UMLS/C0003864 denotes mal model
T17849 3207-3214 UMLS/C1280500 denotes cts ind
T17848 562-569 UMLS/C1549479 denotes mited i
T17847 1705-1724 UMLS/C0876973 denotes lmonary infection [
T17846 5242-5246 UMLS/C0162508 denotes rans
T17845 4642-4645 UMLS/C1833235 denotes -κB
T17844 1406-1411 UMLS/C0384648 denotes -17 m
T17843 4292-4295 UMLS/C1833235 denotes sti
T17842 4264-4267 UMLS/C1833235 denotes , a
T17841 4215-4218 UMLS/C1833235 denotes n m
T17840 4446-4454 UMLS/C0001721 denotes by LY294
T17839 2959-2965 UMLS/C0001721 denotes ect IL
T17838 5242-5246 UMLS/C1333571 denotes rans
T17837 844-849 UMLS/C0384648 denotes -17 w
T17836 603-608 UMLS/C0384648 denotes -17 i
T17835 11-16 UMLS/C0384648 denotes IL-17
T17834 5178-5186 UMLS/C1314939 denotes he induc
T17833 4954-4965 UMLS/C1314939 denotes of PI3K in
T17832 4446-4454 UMLS/C1314939 denotes by LY294
T17831 4332-4341 UMLS/C1314939 denotes histone
T17830 3750-3758 UMLS/C1314939 denotes lved in
T17829 2959-2965 UMLS/C1314939 denotes ect IL
T17828 5440-5451 UMLS/C0004083 denotes ith NF-κB h
T17827 5894-5904 UMLS/C1561536 denotes uccessful
T17826 5809-5817 UMLS/C1561536 denotes IL-17 pr
T17825 4849-4857 UMLS/C1561536 denotes 2 hours
T17824 4491-4499 UMLS/C1561536 denotes as decre
T17823 1447-1455 UMLS/C1561536 denotes tivity r
T17822 4725-4731 UMLS/C1552603 denotes a down
T17821 1903-1908 UMLS/C1704653 denotes lls i
T17820 1570-1575 UMLS/C1704653 denotes lls,
T17819 5782-5790 UMLS/C0332206 denotes κB bindi
T17818 2088-2100 UMLS/C0224522 denotes noviocytes t
T17817 4614-4620 UMLS/C1552596 denotes ations
T17816 2153-2174 UP/O77510 denotes mor necrosis factor-s
T17815 2153-2174 UP/Q75N23 denotes mor necrosis factor-s
T17814 2943-2949 UMLS/C0392905 denotes nts, d
T17813 2039-2045 UMLS/C0392905 denotes ints.
T17812 1924-1930 UMLS/C0392905 denotes ints m
T17811 3471-3493 UMLS/C1621633 denotes ction of cytokines/che
T17810 2943-2949 UMLS/C1269611 denotes nts, d
T17809 2039-2045 UMLS/C1269611 denotes ints.
T17808 1924-1930 UMLS/C1269611 denotes ints m
T17807 5769-5781 UMLS/C0521115 denotes ocking of NF
T17806 2020-2031 UMLS/C1979779 denotes her cells i
T17805 4790-4798 UMLS/C1704632 denotes Akt act
T17804 5440-5451 UMLS/C0596306 denotes ith NF-κB h
T17803 6025-6042 UMLS/C0086982 denotes y is an important
T17802 5294-5311 UMLS/C0086982 denotes hway for cytokine
T17801 5247-5274 UMLS/C0086982 denotes uction pathway, another imp
T17800 3721-3738 UMLS/C0086982 denotes aling pathway was
T17799 3632-3650 UMLS/C0086982 denotes aling pathways. By
T17798 3445-3462 UMLS/C0086982 denotes aling pathway for
T17797 807-824 UMLS/C0086982 denotes gnaling pathway i
T17796 1875-1882 UMLS/C0439855 denotes mplex i
T17795 3016-3022 UMLS/C0332185 denotes ent re
T17794 1696-1704 UMLS/C1513916 denotes gative p
T17793 5801-5808 UMLS/C1167622 denotes in the
T17792 4483-4490 UMLS/C1167622 denotes tivity
T17791 1696-1704 UMLS/C0205160 denotes gative p
T17790 471-483 UMLS/C1293122 denotes gmentation o
T17789 5178-5186 UMLS/C1947935 denotes he induc
T17788 4332-4341 UMLS/C1947935 denotes histone
T17787 3750-3758 UMLS/C1947935 denotes lved in
T17786 2821-2825 UMLS/C0205172 denotes re m
T17785 4614-4620 UMLS/C0439851 denotes ations
T17784 4614-4620 UMLS/C1947931 denotes ations
T17783 3156-3164 UMLS/C1947931 denotes ctly ind
T17782 6019-6024 UMLS/C1623218 denotes pathw
T17781 5825-5830 UMLS/C1623218 denotes y PDT
T17780 5716-5721 UMLS/C1623218 denotes the
T17779 5565-5570 UMLS/C1623218 denotes ing.
T17778 5207-5212 UMLS/C1623218 denotes BMC.
T17777 4994-4999 UMLS/C1623218 denotes . In
T17776 3779-3784 UMLS/C1623218 denotes 7 in
T17775 3508-3513 UMLS/C1623218 denotes 7 has
T17774 3404-3409 UMLS/C1623218 denotes 7 ind
T17773 2738-2743 UMLS/C1623218 denotes -17 i
T17772 2480-2485 UMLS/C1623218 denotes -17 i
T17771 2060-2065 UMLS/C1623218 denotes -17 s
T17770 1495-1500 UMLS/C1623218 denotes -17 i
T17769 1406-1411 UMLS/C1623218 denotes -17 m
T17768 844-849 UMLS/C1623218 denotes -17 w
T17767 603-608 UMLS/C1623218 denotes -17 i
T17766 11-16 UMLS/C1623218 denotes IL-17
T17765 2675-2679 UMLS/C0205170 denotes ll a
T17764 2561-2565 UMLS/C0205170 denotes ll a
T17763 2196-2200 UMLS/C0205170 denotes ll a
T17762 1184-1188 UMLS/C0205170 denotes ll a
T17761 5440-5451 UMLS/C0439849 denotes ith NF-κB h
T17760 4621-4633 UMLS/C0439849 denotes ip between p
T17759 4642-4645 UP/O97628 denotes -κB
T17758 4292-4295 UP/O97628 denotes sti
T17757 4264-4267 UP/O97628 denotes , a
T17756 4215-4218 UP/O97628 denotes n m
T17755 2144-2148 UMLS/C1705592 denotes -8 a
T17754 188-205 UMLS/C0806987 denotes mononuclear cells
T17753 1903-1908 UMLS/C1269647 denotes lls i
T17752 1570-1575 UMLS/C1269647 denotes lls,
T17751 562-569 UMLS/C0205189 denotes mited i
T17750 2366-2371 UMLS/C0963088 denotes -23)
T17749 1661-1666 UMLS/C0963088 denotes -23 t
T17748 4833-4840 UMLS/C0439833 denotes s of ac
T17747 4945-4953 UMLS/C0332149 denotes volvemen
T17746 5130-5136 UMLS/C0332148 denotes the NF
T17745 6001-6014 UMLS/C0162340 denotes e IL-17 signa
T17744 4504-4513 UMLS/C0392756 denotes by LY2940
T17743 4932-4940 UMLS/C1705535 denotes e possib
T17742 3319-3325 UMLS/C1704701 denotes al ind
T17741 5090-5098 UMLS/C0018284 denotes our expe
T17740 2549-2557 UMLS/C0018284 denotes togens a
T17739 1171-1179 UMLS/C0018284 denotes togens,
T17738 4446-4454 UMLS/C0392760 denotes by LY294
T17737 2959-2965 UMLS/C0392760 denotes ect IL
T17736 3706-3714 UMLS/C0332128 denotes ined whi
T17735 612-621 UMLS/C0680651 denotes pealing b
T17734 5474-5482 UMLS/C1709908 denotes liver ac
T17733 3306-3314 UMLS/C1709908 denotes rted for
T17732 3023-3029 UMLS/C1709908 denotes ort th
T17731 3319-3325 UMLS/C1550457 denotes al ind
T17730 172-184 UMLS/C0702249 denotes infiltration
T17729 4168-4176 UMLS/C0332120 denotes nce supp
T17728 2781-2784 UMLS/C0034790 denotes R l
T17727 2683-2686 UMLS/C0034790 denotes R l
T17726 2586-2589 UMLS/C0034790 denotes R)
T17725 2569-2584 UMLS/C0034790 denotes cell receptor (
T17724 1237-1252 UMLS/C0034790 denotes cell receptor,
T17723 5831-5839 UMLS/C0086860 denotes and LY2
T17722 1912-1920 UMLS/C0333348 denotes flamed R
T17721 4642-4645 UP/Q64010 denotes -κB
T17720 4292-4295 UP/Q64010 denotes sti
T17719 4264-4267 UP/Q64010 denotes , a
T17718 4215-4218 UP/Q64010 denotes n m
T17717 3523-3533 UMLS/C1563337 denotes mented wid
T17716 5909-5919 UMLS/C1272703 denotes tion of an
T17715 2153-2174 UP/P51742 denotes mor necrosis factor-s
T17714 5242-5246 UMLS/C0812312 denotes rans
T17713 135-156 UMLS/C0808143 denotes synovial lining cells
T17712 3101-3107 UMLS/C1272696 denotes do so
T17711 2826-2834 UMLS/C0522501 denotes rkedly.
T17710 1589-1598 UMLS/C1314763 denotes enotype [
T17709 3973-3978 UMLS/C0205112 denotes prod
T17708 5415-5425 UMLS/C0522506 denotes nase Akt i
T17707 4738-4748 UMLS/C0522506 denotes pathway of
T17706 5426-5432 UMLS/C0031727 denotes assoc
T17705 3319-3325 UMLS/C1551394 denotes al ind
T17704 164-171 UMLS/C0522510 denotes intense
T17703 1883-1894 UMLS/C1704675 denotes teraction b
T17702 4790-4798 UMLS/C0871261 denotes Akt act
T17701 3800-3810 UMLS/C1551388 denotes tified tha
T17700 5228-5236 UMLS/C1979874 denotes AP-1 si
T17699 2839-2847 UMLS/C1979874 denotes ntrast,
T17698 3041-3050 UMLS/C1444748 denotes ggered in
T17697 1667-1677 UMLS/C1444748 denotes iggering m
T17695 6019-6024 UMLS/C1825592 denotes pathw
T17694 5825-5830 UMLS/C1825592 denotes y PDT
T17693 5716-5721 UMLS/C1825592 denotes the
T17692 5565-5570 UMLS/C1825592 denotes ing.
T17691 5207-5212 UMLS/C1825592 denotes BMC.
T17690 4994-4999 UMLS/C1825592 denotes . In
T17689 3779-3784 UMLS/C1825592 denotes 7 in
T17688 3508-3513 UMLS/C1825592 denotes 7 has
T17687 3404-3409 UMLS/C1825592 denotes 7 ind
T17686 2738-2743 UMLS/C1825592 denotes -17 i
T17685 2480-2485 UMLS/C1825592 denotes -17 i
T17684 2060-2065 UMLS/C1825592 denotes -17 s
T17683 1495-1500 UMLS/C1825592 denotes -17 i
T17682 1406-1411 UMLS/C1825592 denotes -17 m
T17681 844-849 UMLS/C1825592 denotes -17 w
T17680 603-608 UMLS/C1825592 denotes -17 i
T17679 11-16 UMLS/C1825592 denotes IL-17
T17678 390-399 UMLS/C0332218 denotes fficult t
T17677 6081-6084 UMLS/C0205314 denotes rap
T17676 1031-1038 UMLS/C1299351 denotes ghest l
T17675 867-873 UMLS/C1299351 denotes gher i
T17674 2876-2881 UMLS/C0205309 denotes wn to
T17673 2383-2388 UMLS/C0205309 denotes own t
T17672 6059-6066 UMLS/C0013879 denotes oping n
T17671 3319-3325 UMLS/C0205307 denotes al ind
T17670 5974-5987 UMLS/C0599779 denotes ,6,34-36], un
T17669 5575-5582 UMLS/C0332268 denotes ata cle
T17668 525-529 UMLS/C0332268 denotes ck o
T17667 3195-3200 UMLS/C0337876 denotes t exe
T17666 1931-1936 UMLS/C0337876 denotes ght p
T17665 1412-1417 UMLS/C0337876 denotes ght b
T17664 448-451 UMLS/C0337876 denotes y h
T17663 1861-1866 UMLS/C0870071 denotes del [
T17662 3054-3059 UMLS/C0021135 denotes ro IL
T17661 2460-2465 UMLS/C0021135 denotes tro p
T17660 2224-2229 UMLS/C0021135 denotes tro [
T17659 2153-2174 UP/P51435 denotes mor necrosis factor-s
T17658 4782-4789 UMLS/C0205289 denotes ponse o
T17657 4396-4403 UMLS/C1546471 denotes evealed
T17656 664-671 UMLS/C1441547 denotes rived c
T17655 540-547 UMLS/C1441547 denotes rived c
T17654 318-325 UMLS/C1441547 denotes erived
T17579 4365-4385 UP/P45481 denotes ing protein [33]. Ou
T17578 4158-4164 UMLS/C2348044 denotes s of e
T17577 5474-5482 UMLS/C0700287 denotes liver ac
T17576 3306-3314 UMLS/C0700287 denotes rted for
T17575 3023-3029 UMLS/C0700287 denotes ort th
T17574 4504-4513 UMLS/C0205216 denotes by LY2940
T17573 3394-3403 UMLS/C0205217 denotes eases IL-
T17572 2927-2936 UMLS/C0205217 denotes reased in
T17571 2794-2803 UMLS/C0205217 denotes gmented I
T17570 2710-2719 UMLS/C0205217 denotes creased t
T17569 1779-1788 UMLS/C0205217 denotes gmented b
T17568 1428-1437 UMLS/C0205217 denotes creased c
T17567 1254-1263 UMLS/C0205217 denotes creased I
T17566 4690-4697 UMLS/C1705923 denotes future
T17565 2630-2637 UMLS/C1705923 denotes udies d
T17564 721-728 UMLS/C1705923 denotes udies,
T17563 4945-4953 UMLS/C2362652 denotes volvemen
T17562 1834-1860 UMLS/C0971858 denotes llagen-induced arthritis m
T17561 2366-2371 UMLS/C1423526 denotes -23)
T17560 1661-1666 UMLS/C1423526 denotes -23 t
T17559 4139-4150 UMLS/C0543488 denotes esting that
T17558 2153-2174 UP/P59694 denotes mor necrosis factor-s
T17557 2906-2916 UMLS/C0871161 denotes perties an
T17556 702-712 UMLS/C0871161 denotes operties.
T17555 78-88 UMLS/C0871161 denotes properties
T17554 2153-2174 UP/P33620 denotes mor necrosis factor-s
T17553 5588-5592 UMLS/C1511726 denotes emon
T17552 5537-5541 UMLS/C1511726 denotes gnal
T17551 5376-5380 UMLS/C1511726 denotes n).
T17550 2988-2992 UMLS/C1511726 denotes a we
T17549 2263-2267 UMLS/C1511726 denotes ta a
T17548 1363-1367 UMLS/C1511726 denotes ta n
T17547 950-954 UMLS/C1511726 denotes ta a
T17546 4790-4798 UMLS/C1706817 denotes Akt act
T17545 4578-4589 UMLS/C1549571 denotes t of PI3K a
T17544 507-519 UMLS/C0021368 denotes flammation,
T17543 5486-5493 UMLS/C1705822 denotes ting si
T17542 5660-5665 UMLS/C0006823 denotes ortan
T17541 4296-4299 UMLS/C0006823 denotes ula
T17540 3604-3607 UMLS/C0006823 denotes be
T17539 1617-1620 UMLS/C0006823 denotes n a
T17538 1065-1068 UMLS/C0006823 denotes n b
T17537 21-26 UMLS/C0205435 denotes first
T17536 3054-3059 UMLS/C1533691 denotes ro IL
T17535 2460-2465 UMLS/C1533691 denotes tro p
T17534 2224-2229 UMLS/C1533691 denotes tro [
T17533 5242-5246 UP/P21525 denotes rans
T17532 4642-4645 UP/Q04929 denotes -κB
T17531 4292-4295 UP/Q04929 denotes sti
T18017 2153-2174 UP/P36939 denotes mor necrosis factor-s
T18016 1471-1493 UMLS/C0020507 denotes llular proliferation.
T18015 120-131 UMLS/C0020507 denotes hyperplasia
T18014 1812-1828 UMLS/C0009331 denotes pe II collagen i
T18013 4861-4868 UMLS/C1547059 denotes e fact
T18012 4019-4024 UMLS/C0037088 denotes that
T18011 1325-1330 UMLS/C0037088 denotes und,
T18010 855-860 UMLS/C0037088 denotes und t
T18009 2144-2148 UMLS/C0079633 denotes -8 a
T18008 21-26 UMLS/C1279901 denotes first
T18007 5660-5665 UMLS/C0344312 denotes ortan
T18006 4296-4299 UMLS/C0344312 denotes ula
T18005 3604-3607 UMLS/C0344312 denotes be
T18004 1617-1620 UMLS/C0344312 denotes n a
T18003 1065-1068 UMLS/C0344312 denotes n b
T18002 1589-1598 UMLS/C1285572 denotes enotype [
T18001 3523-3533 UMLS/C1301746 denotes mented wid
T18000 6025-6042 UMLS/C0037080 denotes y is an important
T17999 5294-5311 UMLS/C0037080 denotes hway for cytokine
T17998 3721-3738 UMLS/C0037080 denotes aling pathway was
T17997 3632-3650 UMLS/C0037080 denotes aling pathways. By
T17996 3445-3462 UMLS/C0037080 denotes aling pathway for
T17995 807-824 UMLS/C0037080 denotes gnaling pathway i
T17994 5549-5555 UMLS/C0037083 denotes g IL-1
T17993 5505-5512 UMLS/C0037083 denotes y cell
T17992 1215-1224 UMLS/C0037083 denotes gnaling t
T17991 4365-4385 UMLS/C0256079 denotes ing protein [33]. Ou
T17990 4101-4109 UMLS/C0297666 denotes 580, a p
T17989 2943-2949 UMLS/C1706309 denotes nts, d
T17988 2039-2045 UMLS/C1706309 denotes ints.
T17987 1924-1930 UMLS/C1706309 denotes ints m
T17986 1691-1695 UMLS/C0331538 denotes am-n
T17985 5619-5623 UMLS/C1705325 denotes esul
T17984 5402-5406 UMLS/C1705325 denotes down
T17983 4969-4973 UMLS/C1705325 denotes ind
T17982 4760-4764 UMLS/C1705325 denotes to
T17981 4593-4597 UMLS/C1705325 denotes atio
T17980 3895-3899 UMLS/C1705325 denotes inh
T17979 5010-5014 UMLS/C0449911 denotes fac
T17978 4621-4633 UMLS/C1706279 denotes ip between p
T17977 459-463 UMLS/C1704326 denotes le i
T17976 2497-2510 UMLS/C1553423 denotes sponding to a
T17975 906-920 UMLS/C0039097 denotes novial fluid [
T17974 880-894 UMLS/C0039097 denotes novial fluid t
T17973 416-424 UMLS/C0039099 denotes novium [
T17972 289-297 UMLS/C0039099 denotes ynovium,
T17971 3319-3325 UMLS/C1873497 denotes al ind
T17970 5516-5520 UMLS/C0439064 denotes s, t
T17969 2821-2825 UMLS/C0439064 denotes re m
T17968 5326-5336 UMLS/C1527036 denotes as not act
T17967 3494-3504 UMLS/C1527036 denotes okines by
T17966 2534-2544 UMLS/C1527036 denotes emokines a
T17965 1988-1998 UMLS/C1527036 denotes emokines,
T17964 49-56 UMLS/C1704444 denotes product
T17963 5749-5760 UMLS/C1706386 denotes wing simult
T17962 5363-5374 UMLS/C1706386 denotes data not sh
T17961 5106-5117 UMLS/C1706386 denotes it is most
T17960 4708-4719 UMLS/C1706386 denotes . The searc
T17959 1151-1162 UMLS/C1706386 denotes periments,
T17958 103-116 UMLS/C1880022 denotes characterized
T17957 3514-3517 UMLS/C2348947 denotes bee
T17956 633-636 UMLS/C2348947 denotes s b
T17955 558-561 UMLS/C2348947 denotes s l
T17954 6081-6084 UMLS/C1553390 denotes rap
T17953 2781-2784 UMLS/C1167203 denotes R l
T17952 2683-2686 UMLS/C1167203 denotes R l
T17951 2586-2589 UMLS/C1167203 denotes R)
T17950 2144-2148 UMLS/C1366571 denotes -8 a
T17949 3229-3236 UMLS/C0039194 denotes lls thr
T17948 1792-1799 UMLS/C0039194 denotes cells r
T17947 1646-1653 UMLS/C0039194 denotes cells v
T17946 1538-1545 UMLS/C0039194 denotes cells,
T17945 657-663 UMLS/C0039194 denotes cell-d
T17944 533-539 UMLS/C0039194 denotes cell-d
T17943 440-447 UMLS/C0039194 denotes cells m
T17942 311-317 UMLS/C0039194 denotes cell-
T17941 42-48 UMLS/C0039194 denotes T cell
T17940 4920-4931 UMLS/C1948023 denotes suggests t
T17939 4300-4309 UMLS/C1948023 denotes e NF-κB b
T17938 3998-4009 UMLS/C1948023 denotes lation. We
T17937 2297-2306 UMLS/C1948023 denotes imulate I
T17936 2175-2185 UMLS/C1948023 denotes imulated g
T17935 2066-2076 UMLS/C1948023 denotes imulates r
T17934 1103-1114 UMLS/C1948023 denotes imulation i
T17933 984-993 UMLS/C1948023 denotes imulate I
T17932 3523-3533 UMLS/C1548385 denotes mented wid
T17931 3293-3301 UMLS/C2242979 denotes ures. As
T17930 4690-4697 UMLS/C2603343 denotes future
T17929 2630-2637 UMLS/C2603343 denotes udies d
T17928 721-728 UMLS/C2603343 denotes udies,
T17927 3263-3272 UMLS/C0200637 denotes cytes/mac
T17926 4504-4513 UMLS/C0547047 denotes by LY2940
T17925 4642-4645 UMLS/C1705633 denotes -κB
T17924 4292-4295 UMLS/C1705633 denotes sti
T17923 2104-2111 UMLS/C1327616 denotes crete s
T17922 4264-4267 UMLS/C1705633 denotes , a
T17921 2906-2916 UMLS/C1704391 denotes perties an
T17920 702-712 UMLS/C1704391 denotes operties.
T17919 78-88 UMLS/C1704391 denotes properties
T17918 4215-4218 UMLS/C1705633 denotes n m
T17917 4621-4633 UMLS/C1705630 denotes ip between p
T17916 5619-5623 UP/P42336 denotes esul
T17915 5402-5406 UP/P42336 denotes down
T17914 4969-4973 UP/P42336 denotes ind
T17913 4760-4764 UP/P42336 denotes to
T17912 4593-4597 UP/P42336 denotes atio
T17911 3895-3899 UP/P42336 denotes inh
T17910 4690-4697 UMLS/C2349977 denotes future
T17909 2630-2637 UMLS/C2349977 denotes udies d
T17908 721-728 UMLS/C2349977 denotes udies,
T17907 1471-1493 UMLS/C0596290 denotes llular proliferation.
T17906 1337-1355 UMLS/C0596290 denotes ll proliferation a
T17905 3293-3301 UMLS/C0430400 denotes ures. As
T17904 4578-4589 UMLS/C1299583 denotes t of PI3K a
T17903 3101-3107 UMLS/C1879934 denotes do so
T17902 6019-6024 UMLS/C0384648 denotes pathw
T17901 5825-5830 UMLS/C0384648 denotes y PDT
T17900 5716-5721 UMLS/C0384648 denotes the
T17899 5565-5570 UMLS/C0384648 denotes ing.
T17898 5207-5212 UMLS/C0384648 denotes BMC.
T17897 4322-4331 UMLS/C1706376 denotes involvin
T17896 1678-1687 UMLS/C1706376 denotes chanism i
T17895 4642-4645 UMLS/C1412886 denotes -κB
T17894 4292-4295 UMLS/C1412886 denotes sti
T17893 4264-4267 UMLS/C1412886 denotes , a
T17892 4215-4218 UMLS/C1412886 denotes n m
T17891 2943-2949 UMLS/C0022417 denotes nts, d
T17890 2039-2045 UMLS/C0022417 denotes ints.
T17889 1924-1930 UMLS/C0022417 denotes ints m
T17888 6059-6066 UMLS/C1705248 denotes oping n
T17887 3523-3533 UMLS/C1301725 denotes mented wid
T17886 4342-4364 UMLS/C0390904 denotes cetylase p300/CREB-bin
T17885 4820-4826 UMLS/C1442450 denotes a grad
T17884 5242-5246 UMLS/C0087140 denotes rans
T17883 49-56 UMLS/C1550506 denotes product
T17882 3293-3301 UMLS/C0220814 denotes ures. As
T17881 1589-1598 UMLS/C0031437 denotes enotype [
T17880 742-750 UMLS/C0220825 denotes aluate h
T17879 1654-1657 UMLS/C1550513 denotes a a
T17878 4994-4999 UMLS/C0384648 denotes . In
T17877 3195-3200 UMLS/C0454788 denotes t exe
T17876 1931-1936 UMLS/C0454788 denotes ght p
T17875 1412-1417 UMLS/C0454788 denotes ght b
T17874 448-451 UMLS/C0454788 denotes y h
T17873 1903-1908 UMLS/C1136359 denotes lls i
T17872 1570-1575 UMLS/C1136359 denotes lls,
T17871 3207-3214 UMLS/C2348382 denotes cts ind
T17870 3326-3337 UMLS/C1550471 denotes viduals [25
T17530 4264-4267 UP/Q04929 denotes , a
T17529 4215-4218 UP/Q04929 denotes n m
T17528 3273-3284 UMLS/C1550652 denotes ophages in
T17527 2153-2174 UP/P23383 denotes mor necrosis factor-s
T17526 4954-4965 UMLS/C0205428 denotes of PI3K in
T17525 2513-2520 UMLS/C2346866 denotes riety o
T17524 1947-1954 UMLS/C2346866 denotes riety o
T17523 2153-2174 UP/Q1G1A2 denotes mor necrosis factor-s
T17522 4322-4331 UMLS/C0441712 denotes involvin
T17521 1678-1687 UMLS/C0441712 denotes chanism i
T17520 172-184 UMLS/C0332448 denotes infiltration
T17519 4365-4385 UP/Q92793 denotes ing protein [33]. Ou
T17518 3624-3631 UMLS/C0205423 denotes ain sig
T17517 1031-1038 UMLS/C1522410 denotes ghest l
T17516 867-873 UMLS/C1522410 denotes gher i
T17515 3800-3810 UMLS/C0205396 denotes tified tha
T17514 5801-5808 UMLS/C1689898 denotes in the
T17513 4483-4490 UMLS/C1689898 denotes tivity
T17512 2153-2174 UP/Q8WNR1 denotes mor necrosis factor-s
T17511 3523-3533 UMLS/C1547673 denotes mented wid
T17510 562-569 UMLS/C1549649 denotes mited i
T17509 5894-5904 UMLS/C0441655 denotes uccessful
T17508 5809-5817 UMLS/C0441655 denotes IL-17 pr
T17507 4849-4857 UMLS/C0441655 denotes 2 hours
T17506 4491-4499 UMLS/C0441655 denotes as decre
T17505 1447-1455 UMLS/C0441655 denotes tivity r
T17504 2153-2174 UMLS/C1456820 denotes mor necrosis factor-s
T17503 2153-2174 UP/Q9BEA1 denotes mor necrosis factor-s
T17502 2153-2174 UP/Q19LH4 denotes mor necrosis factor-s
T17501 2259-2262 UMLS/C0205388 denotes w d
T17500 946-949 UMLS/C0205388 denotes w d
T17499 562-569 UMLS/C0449295 denotes mited i
T17498 5624-5627 UP/Q8INB9 denotes ant
T17497 5433-5436 UP/Q8INB9 denotes ati
T17496 4884-4887 UP/Q8INB9 denotes pho
T17495 4802-4805 UP/Q8INB9 denotes ion
T17494 5242-5246 UP/A8MPH9 denotes rans
T17493 4504-4513 UMLS/C0442797 denotes by LY2940
T17492 4089-4097 UMLS/C1883712 denotes ion of S
T17491 2756-2762 UMLS/C1883712 denotes ding I
T17490 1734-1742 UMLS/C1883712 denotes dition,
T17489 3394-3403 UMLS/C0442805 denotes eases IL-
T17488 2927-2936 UMLS/C0442805 denotes reased in
T17487 2710-2719 UMLS/C0442805 denotes creased t
T17486 1428-1437 UMLS/C0442805 denotes creased c
T17485 1254-1263 UMLS/C0442805 denotes creased I
T17484 4690-4697 UMLS/C0557651 denotes future
T17483 2630-2637 UMLS/C0557651 denotes udies d
T17482 721-728 UMLS/C0557651 denotes udies,
T17481 2051-2058 UMLS/C1707959 denotes ample,
T17480 3394-3403 UMLS/C0442808 denotes eases IL-
T17479 2927-2936 UMLS/C0442808 denotes reased in
T17478 2710-2719 UMLS/C0442808 denotes creased t
T17477 1428-1437 UMLS/C0442808 denotes creased c
T17476 1254-1263 UMLS/C0442808 denotes creased I
T17475 459-463 UMLS/C1705809 denotes le i
T17474 459-463 UMLS/C1705812 denotes le i
T17473 471-483 UMLS/C0332509 denotes gmentation o
T17472 459-463 UMLS/C1705810 denotes le i
T17471 459-463 UMLS/C1705811 denotes le i
T17470 2849-2853 UMLS/C1522428 denotes -1 a
T17469 246-250 UMLS/C1522428 denotes IL-1
T17468 4177-4185 UMLS/C0183683 denotes rts cros
T17467 3963-3969 UMLS/C0456079 denotes s of b
T17466 1039-1044 UMLS/C0456079 denotes vel o
T17465 834-840 UMLS/C0456079 denotes vels o
T17464 2153-2174 UP/P06804 denotes mor necrosis factor-s
T17463 2285-2291 UMLS/C1254351 denotes ents t
T17462 972-978 UMLS/C1254351 denotes ents t
T17461 2849-2853 UMLS/C1149212 denotes -1 a
T17460 246-250 UMLS/C1149212 denotes IL-1
T17459 3523-3533 UMLS/C1609436 denotes mented wid
T17458 4642-4645 UP/P46108 denotes -κB
T17457 4292-4295 UP/P46108 denotes sti
T17456 4264-4267 UP/P46108 denotes , a
T17455 4215-4218 UP/P46108 denotes n m
T17454 5081-5086 UMLS/C1149222 denotes ogens
T17453 3035-3040 UMLS/C1149222 denotes 15 tr
T17452 2763-2768 UMLS/C1149222 denotes -15 o
T17451 2656-2661 UMLS/C1149222 denotes -15 a
T17450 2356-2361 UMLS/C1149222 denotes -15 a
T17449 1164-1167 UMLS/C0030779 denotes A a
T17448 2153-2174 UP/Q1WM27 denotes mor necrosis factor-s
T17447 459-463 UMLS/C0035820 denotes le i
T17446 3963-3969 UMLS/C0441889 denotes s of b
T17445 1039-1044 UMLS/C0441889 denotes vel o
T17444 834-840 UMLS/C0441889 denotes vels o
T17443 2366-2371 UMLS/C1149233 denotes -23)
T17442 1661-1666 UMLS/C1149233 denotes -23 t
T17441 2440-2452 UMLS/C1292732 denotes vestigated t
T17440 5081-5086 UMLS/C0254610 denotes ogens
T17439 3035-3040 UMLS/C0254610 denotes 15 tr
T17438 2763-2768 UMLS/C0254610 denotes -15 o
T17437 2656-2661 UMLS/C0254610 denotes -15 a
T17436 2356-2361 UMLS/C0254610 denotes -15 a
T17435 348-352 UMLS/C1149239 denotes L-4
T17434 2138-2142 UMLS/C1149241 denotes -6,
T17433 1356-1361 UMLS/C1510438 denotes say (
T17432 2153-2174 UMLS/C2700093 denotes mor necrosis factor-s
T17431 664-671 UMLS/C1711343 denotes rived c
T17430 540-547 UMLS/C1711343 denotes rived c
T17429 318-325 UMLS/C1711343 denotes erived
T17428 5769-5781 UMLS/C1548968 denotes ocking of NF
T17427 2153-2174 UMLS/C0041368 denotes mor necrosis factor-s
T17426 5649-5659 UMLS/C1879547 denotes d be an im
T17425 5494-5504 UMLS/C1879547 denotes nals in ma
T17424 5346-5355 UMLS/C1879547 denotes our exper
T17423 5048-5057 UMLS/C1879547 denotes anti-CD3
T17422 4806-4816 UMLS/C1879547 denotes at 1 hour
T17421 4598-4608 UMLS/C1879547 denotes . The dire
T17420 4282-4291 UMLS/C1879547 denotes d p38 can
T17419 4251-4260 UMLS/C1879547 denotes d by p38
T17418 3249-3259 UMLS/C1879547 denotes vation of
T17417 2011-2019 UMLS/C1879547 denotes tivate o
T17416 1523-1532 UMLS/C1879547 denotes tivated C
T17415 4223-4231 UMLS/C0596981 denotes es, IκB
T17414 4690-4697 UMLS/C0008972 denotes future
T17413 2630-2637 UMLS/C0008972 denotes udies d
T17412 721-728 UMLS/C0008972 denotes udies,
T17411 5440-5451 UMLS/C0699792 denotes ith NF-κB h
T17410 4690-4697 UMLS/C0008976 denotes future
T17409 2630-2637 UMLS/C0008976 denotes udies d
T17408 721-728 UMLS/C0008976 denotes udies,
T17407 5081-5086 UMLS/C1334105 denotes ogens
T17406 3035-3040 UMLS/C1334105 denotes 15 tr
T17405 2763-2768 UMLS/C1334105 denotes -15 o
T17404 2656-2661 UMLS/C1334105 denotes -15 a
T17403 2356-2361 UMLS/C1334105 denotes -15 a
T17402 2756-2762 UMLS/C1524062 denotes ding I
T17401 3800-3810 UMLS/C1550043 denotes tified tha
T17400 2138-2142 UMLS/C1527132 denotes -6,
T17399 2998-3013 UMLS/C1524057 denotes sistent with a
T17398 1438-1446 UMLS/C0178539 denotes llular a
T17397 3570-3579 UMLS/C0470187 denotes lable on
T17396 2268-2277 UMLS/C0470187 denotes ailable o
T17395 955-964 UMLS/C0470187 denotes ailable o
T17394 348-352 UMLS/C1522540 denotes L-4
T17393 3273-3284 UMLS/C1546706 denotes ophages in
T17392 4158-4164 UMLS/C0205549 denotes s of e
T17391 2153-2174 UP/P04924 denotes mor necrosis factor-s
T17390 3150-3155 UMLS/C1522558 denotes 1 dir
T17389 2772-2777 UMLS/C1522558 denotes P-1 t
T17388 2666-2671 UMLS/C1522558 denotes P-1 a
T17387 2153-2174 UP/P01375 denotes mor necrosis factor-s
T17386 2144-2148 UMLS/C1149173 denotes -8 a
T17385 2153-2174 UP/P16599 denotes mor necrosis factor-s
T17384 5316-5325 UMLS/C1524094 denotes mokines,
T17383 2524-2533 UMLS/C1524094 denotes tokines/c
T17382 2345-2354 UMLS/C1524094 denotes tokines (
T17381 2120-2129 UMLS/C1524094 denotes tokines s
T17380 1974-1983 UMLS/C1524094 denotes tokines a
T17379 672-680 UMLS/C1524094 denotes tokine w
T17378 548-557 UMLS/C1524094 denotes tokines h
T17377 326-335 UMLS/C1524094 denotes ytokines,
T17376 228-237 UMLS/C1524094 denotes cytokines
T17375 348-352 UMLS/C0021758 denotes L-4
T17374 1031-1038 UMLS/C1561957 denotes ghest l
T17373 867-873 UMLS/C1561957 denotes gher i
T17372 1031-1038 UMLS/C1561958 denotes ghest l
T17371 867-873 UMLS/C1561958 denotes gher i
T17370 6081-6084 UMLS/C1578513 denotes rap
T17369 2138-2142 UMLS/C0021760 denotes -6,
T17368 5736-5741 UMLS/C1527178 denotes perim
T17367 5852-5860 UMLS/C0251991 denotes ering it
T17366 4517-4525 UMLS/C0251991 denotes which pr
T17365 4458-4466 UMLS/C0251991 denotes whereas
T17364 3910-3918 UMLS/C0251991 denotes 4002 and
T17354 2738-2743 UMLS/C1522571 denotes -17 i
T17353 2480-2485 UMLS/C1522571 denotes -17 i
T17352 2060-2065 UMLS/C1522571 denotes -17 s
T17351 1495-1500 UMLS/C1522571 denotes -17 i
T17350 1406-1411 UMLS/C1522571 denotes -17 m
T17349 844-849 UMLS/C1522571 denotes -17 w
T17348 603-608 UMLS/C1522571 denotes -17 i
T17347 11-16 UMLS/C1522571 denotes IL-17
T17346 4920-4931 UMLS/C1292856 denotes suggests t
T17345 3998-4009 UMLS/C1292856 denotes lation. We
T17344 1103-1114 UMLS/C1292856 denotes imulation i
T17343 2138-2142 UMLS/C1334122 denotes -6,
T17342 3150-3155 UMLS/C1705079 denotes 1 dir
T17341 2772-2777 UMLS/C1705079 denotes P-1 t
T17340 2666-2671 UMLS/C1705079 denotes P-1 a
T17339 2849-2853 UMLS/C0021755 denotes -1 a
T17338 246-250 UMLS/C0021755 denotes IL-1
T17337 2849-2853 UMLS/C0021753 denotes -1 a
T17336 246-250 UMLS/C0021753 denotes IL-1
T17335 348-352 UMLS/C1334119 denotes L-4
T17334 4725-4731 UMLS/C1706202 denotes a down
T17333 5843-5847 UMLS/C0084183 denotes 2. C
T17332 3944-3948 UMLS/C0084183 denotes to c
T17331 2153-2174 UP/P51743 denotes mor necrosis factor-s
T17330 2285-2291 UMLS/C0450442 denotes ents t
T17329 972-978 UMLS/C0450442 denotes ents t
T17328 5619-5623 UMLS/C1368105 denotes esul
T17327 5402-5406 UMLS/C1368105 denotes down
T17326 4969-4973 UMLS/C1368105 denotes ind
T17325 4760-4764 UMLS/C1368105 denotes to
T17324 4593-4597 UMLS/C1368105 denotes atio
T17323 3895-3899 UMLS/C1368105 denotes inh
T17322 1883-1894 UMLS/C0687133 denotes teraction b
T17321 5749-5760 UMLS/C0681814 denotes wing simult
T17320 5363-5374 UMLS/C0681814 denotes data not sh
T17319 5106-5117 UMLS/C0681814 denotes it is most
T17318 4708-4719 UMLS/C0681814 denotes . The searc
T17317 1151-1162 UMLS/C0681814 denotes periments,
T17316 5782-5790 UMLS/C1706084 denotes κB bindi
T17315 2153-2174 UMLS/C1323304 denotes mor necrosis factor-s
T17314 3344-3361 UMLS/C1155065 denotes ll activation thr
T17313 3173-3190 UMLS/C1155065 denotes ll activation, it
T17312 4365-4385 UMLS/C1337090 denotes ing protein [33]. Ou
T17311 3934-3943 UMLS/C0243077 denotes itor PDTC
T17310 3900-3909 UMLS/C0243077 denotes bitor LY2
T17309 1356-1361 UMLS/C0243073 denotes say (
T17308 3150-3155 UMLS/C1337092 denotes 1 dir
T17307 2772-2777 UMLS/C1337092 denotes P-1 t
T17306 2666-2671 UMLS/C1337092 denotes P-1 a
T17653 562-569 UMLS/C0439801 denotes mited i
T17652 5440-5451 UMLS/C1704771 denotes ith NF-κB h
T17651 5440-5451 UMLS/C1704770 denotes ith NF-κB h
T17650 3661-3691 UMLS/C1519313 denotes al transduction inhibitors, we
T17649 5521-5531 UMLS/C0449475 denotes e data on
T17648 2153-2174 UP/Q8MKG8 denotes mor necrosis factor-s
T17647 3293-3301 UMLS/C0010453 denotes ures. As
T17646 5153-5160 UMLS/C1705987 denotes so acti
T17645 4749-4756 UMLS/C1705987 denotes PI3K se
T17644 4570-4577 UMLS/C1705987 denotes depende
T17643 5619-5623 UMLS/C1150481 denotes esul
T17642 5402-5406 UMLS/C1150481 denotes down
T17641 4969-4973 UMLS/C1150481 denotes ind
T17640 4760-4764 UMLS/C1150481 denotes to
T17639 4593-4597 UMLS/C1150481 denotes atio
T17638 3895-3899 UMLS/C1150481 denotes inh
T17637 2153-2174 UP/P59684 denotes mor necrosis factor-s
T17636 5381-5384 UMLS/C1518422 denotes lth
T17635 5342-5345 UMLS/C1518422 denotes in
T17634 4442-4445 UMLS/C1518422 denotes ted
T17633 1577-1580 UMLS/C1518422 denotes t t
T17632 1368-1371 UMLS/C1518422 denotes t s
T17631 1164-1167 UMLS/C0031858 denotes A a
T17630 3624-3631 UMLS/C1704787 denotes ain sig
T17629 642-651 UMLS/C1552738 denotes scribed a
T17628 27-36 UMLS/C1552738 denotes described
T17627 4945-4953 UMLS/C1705910 denotes volvemen
T17626 6085-6093 UMLS/C0599894 denotes es in RA
T17625 2906-2916 UMLS/C1705912 denotes perties an
T17624 702-712 UMLS/C1705912 denotes operties.
T17623 78-88 UMLS/C1705912 denotes properties
T17622 5920-5929 UMLS/C0205263 denotes i-IL-17 f
T17621 5556-5564 UMLS/C0205263 denotes are lac
T17620 5194-5203 UMLS/C0205263 denotes IL-17 in
T17619 4981-4990 UMLS/C0205263 denotes f IL-17 i
T17618 4039-4046 UMLS/C0205263 denotes ed IL-1
T17617 3825-3832 UMLS/C0205263 denotes ced IL-
T17616 3766-3775 UMLS/C0205263 denotes ction of
T17615 3410-3419 UMLS/C0205263 denotes ction in
T17614 3165-3172 UMLS/C0205263 denotes ces T c
T17613 2998-3013 UMLS/C0332290 denotes sistent with a
T17612 2153-2174 UP/P79374 denotes mor necrosis factor-s
T17611 3552-3559 UMLS/C1546437 denotes ata hav
T17610 3137-3144 UMLS/C1546437 denotes ata tha
T17609 1031-1038 UMLS/C0205250 denotes ghest l
T17608 867-873 UMLS/C0205250 denotes gher i
T17607 2153-2174 UP/P79337 denotes mor necrosis factor-s
T17606 4396-4403 UMLS/C1274040 denotes evealed
T17605 4396-4403 UMLS/C0332294 denotes evealed
T17604 2153-2174 UP/P59693 denotes mor necrosis factor-s
T17603 5549-5555 UMLS/C1710082 denotes g IL-1
T17602 5505-5512 UMLS/C1710082 denotes y cell
T17601 1215-1224 UMLS/C1710082 denotes gnaling t
T17600 4578-4589 UMLS/C0332291 denotes t of PI3K a
T17599 4642-4645 UMLS/C1150588 denotes -κB
T17598 4292-4295 UMLS/C1150588 denotes sti
T17597 4264-4267 UMLS/C1150588 denotes , a
T17596 4215-4218 UMLS/C1150588 denotes n m
T17595 4533-4558 UMLS/C1698593 denotes he evidence for a p38 MAP
T17594 403-409 UMLS/C0442726 denotes tect i
T17593 2153-2174 UP/Q8HZD9 denotes mor necrosis factor-s
T17592 3319-3325 UMLS/C2347086 denotes al ind
T17591 6059-6066 UMLS/C0021223 denotes oping n
T17590 5920-5929 UMLS/C1621983 denotes i-IL-17 f
T17589 5194-5203 UMLS/C1621983 denotes IL-17 in
T17588 4981-4990 UMLS/C1621983 denotes f IL-17 i
T17587 3766-3775 UMLS/C1621983 denotes ction of
T17586 3410-3419 UMLS/C1621983 denotes ction in
T17585 5700-5712 UMLS/C0041904 denotes IL-17 in RA
T17584 1390-1402 UMLS/C0041904 denotes regulation o
T17583 2144-2148 UMLS/C1527432 denotes -8 a
T17582 664-671 UMLS/C2348040 denotes rived c
T17581 540-547 UMLS/C2348040 denotes rived c
T17580 318-325 UMLS/C2348040 denotes erived
T17305 4642-4645 UP/Q9NV58 denotes -κB
T17304 4292-4295 UP/Q9NV58 denotes sti
T17303 4264-4267 UP/Q9NV58 denotes , a
T17302 4215-4218 UP/Q9NV58 denotes n m
T17301 1861-1866 UMLS/C0335295 denotes del [
T17300 5782-5790 UMLS/C1533157 denotes κB bindi
T17299 2906-2916 UMLS/C2347695 denotes perties an
T17298 702-712 UMLS/C2347695 denotes operties.
T17297 78-88 UMLS/C2347695 denotes properties
T17296 4561-4569 UP/Q16539 denotes athway i
T17295 4418-4426 UP/Q16539 denotes activati
T17294 4113-4121 UP/Q16539 denotes APK inhi
T17293 2756-2762 UMLS/C1720086 denotes ding I
T17292 2785-2793 UMLS/C0023690 denotes gation a
T17291 2687-2695 UMLS/C0023690 denotes gation s
T17290 5483-5485 UMLS/C0319022 denotes iv
T17289 4772-4774 UMLS/C0319022 denotes ax
T17288 4684-4686 UMLS/C0319022 denotes ed
T17287 3949-3951 UMLS/C0319022 denotes mp
T17286 2921-2923 UMLS/C0319022 denotes be
T17285 2882-2884 UMLS/C0319022 denotes ha
T17284 2778-2780 UMLS/C0319022 denotes T
T17283 2389-2391 UMLS/C0319022 denotes r
T17282 2101-2103 UMLS/C0319022 denotes s
T17281 2591-2599 UMLS/C0023690 denotes gation u
T17280 4690-4697 UMLS/C1880229 denotes future
T17279 2630-2637 UMLS/C1880229 denotes udies d
T17278 721-728 UMLS/C1880229 denotes udies,
T17277 2513-2520 UMLS/C1883525 denotes riety o
T17276 1947-1954 UMLS/C1883525 denotes riety o
T17275 1468-1470 UMLS/C0319022 denotes c
T17274 4561-4569 UMLS/C1120843 denotes athway i
T17273 4418-4426 UMLS/C1120843 denotes activati
T17272 4113-4121 UMLS/C1120843 denotes APK inhi
T17271 383-389 UMLS/C0700164 denotes oved d
T17270 2153-2174 UMLS/C1522668 denotes mor necrosis factor-s
T17269 5619-5623 UMLS/C0285761 denotes esul
T17268 5402-5406 UMLS/C0285761 denotes down
T17267 4969-4973 UMLS/C0285761 denotes ind
T17266 4760-4764 UMLS/C0285761 denotes to
T17265 4593-4597 UMLS/C0285761 denotes atio
T17264 3895-3899 UMLS/C0285761 denotes inh
T17263 3086-3089 UMLS/C0005341 denotes TN
T17262 1425-1427 UMLS/C0319022 denotes i
T17261 861-863 UMLS/C0319022 denotes b
T17260 739-741 UMLS/C0319022 denotes e
T17259 400-402 UMLS/C0319022 denotes d
T17258 266-274 UMLS/C2346714 denotes bundant
T17257 5782-5790 UMLS/C0028778 denotes κB bindi
T17256 1861-1866 UMLS/C0302143 denotes del [
T17255 5782-5790 UMLS/C0233660 denotes κB bindi
T17254 383-389 UMLS/C0456369 denotes oved d
T17253 4690-4697 UMLS/C0947630 denotes future
T17252 2630-2637 UMLS/C0947630 denotes udies d
T17251 721-728 UMLS/C0947630 denotes udies,
T17250 49-56 UMLS/C1514468 denotes product
T17249 4578-4589 UMLS/C0085862 denotes t of PI3K a
T17248 4561-4569 UP/P41279 denotes athway i
T17247 4418-4426 UP/P41279 denotes activati
T17246 4113-4121 UP/P41279 denotes APK inhi
T17245 5801-5808 UMLS/C1145667 denotes in the
T17244 4483-4490 UMLS/C1145667 denotes tivity
T17243 172-184 UMLS/C1523986 denotes infiltration
T17242 5801-5808 UMLS/C2349209 denotes in the
T17241 4483-4490 UMLS/C2349209 denotes tivity
T17240 562-569 UMLS/C2349209 denotes mited i
T17239 4117-4131 UMLS/C1513344 denotes inhibitor. It
T17238 5316-5325 UMLS/C0079189 denotes mokines,
T17237 2524-2533 UMLS/C0079189 denotes tokines/c
T17236 2345-2354 UMLS/C0079189 denotes tokines (
T17235 2120-2129 UMLS/C0079189 denotes tokines s
T17234 1974-1983 UMLS/C0079189 denotes tokines a
T17233 672-680 UMLS/C0079189 denotes tokine w
T17232 548-557 UMLS/C0079189 denotes tokines h
T17231 326-335 UMLS/C0079189 denotes ytokines,
T17230 228-237 UMLS/C0079189 denotes cytokines
T17229 5242-5246 UMLS/C0085828 denotes rans
T17228 4642-4645 UMLS/C1366876 denotes -κB
T17227 4292-4295 UMLS/C1366876 denotes sti
T17226 4264-4267 UMLS/C1366876 denotes , a
T17225 4215-4218 UMLS/C1366876 denotes n m
T17224 4177-4185 UMLS/C1521721 denotes rts cros
T17363 6019-6024 UMLS/C1522571 denotes pathw
T17362 5825-5830 UMLS/C1522571 denotes y PDT
T17361 5716-5721 UMLS/C1522571 denotes the
T17360 5565-5570 UMLS/C1522571 denotes ing.
T17359 5207-5212 UMLS/C1522571 denotes BMC.
T17358 4994-4999 UMLS/C1522571 denotes . In
T17357 3779-3784 UMLS/C1522571 denotes 7 in
T17356 3508-3513 UMLS/C1522571 denotes 7 has
T17355 3404-3409 UMLS/C1522571 denotes 7 ind

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T19436 6091-6093 NN denotes RA
T19435 6088-6090 IN denotes in
T19434 6078-6087 NN denotes therapies
T19433 6069-6077 VB denotes targeted
T19432 6065-6068 JJ denotes new
T19431 6054-6064 VB denotes developing
T19430 6051-6053 IN denotes of
T19429 6043-6050 NN denotes element
T19428 6033-6042 JJ denotes important
T19427 6030-6032 DT denotes an
T19426 6027-6029 VB denotes is
T19425 6019-6026 NN denotes pathway
T19424 6009-6018 NN denotes signaling
T19423 6003-6008 NN denotes IL-17
T19422 5999-6002 DT denotes the
T19421 5985-5998 VB denotes understanding
T19420 5983-5984 -COMMA- denotes ,
T19419 5982-5983 -RRB- denotes ]
T19418 5973-5982 CD denotes 2,6,34-36
T19417 5972-5973 -LRB- denotes [
T19416 5965-5971 NN denotes models
T19415 5958-5964 NN denotes animal
T19414 5955-5957 IN denotes in
T19413 5945-5954 NN denotes arthritis
T19412 5932-5944 VB denotes ameliorating
T19411 5928-5931 IN denotes for
T19410 5917-5927 NN denotes anti-IL-17
T19409 5914-5916 IN denotes of
T19408 5904-5913 NN denotes induction
T19407 5893-5903 JJ denotes successful
T19406 5889-5892 CC denotes and
T19405 5878-5888 NN denotes activities
T19404 5862-5877 JJ denotes proinflammatory
T19403 5858-5861 PRP-DOLLAR- denotes its
T19402 5846-5857 VB denotes Considering
T19401 5836-5844 NN denotes LY294002
T19400 5832-5835 CC denotes and
T19395 5805-5808 DT denotes the
T19394 5802-5804 IN denotes in
T19393 5793-5801 NN denotes activity
T19392 5785-5792 NN denotes binding
T19391 5779-5784 NN denotes NF-κB
T19390 5776-5778 IN denotes of
T19389 5767-5775 NN denotes blocking
T19388 5754-5766 JJ denotes simultaneous
T19387 5746-5753 VB denotes showing
T19386 5734-5745 NN denotes experiments
T19385 5730-5733 PRP-DOLLAR- denotes our
T19384 5727-5729 IN denotes of
T19383 5721-5726 NN denotes basis
T19382 5717-5720 DT denotes the
T19381 5714-5716 IN denotes on
T19380 5712-5713 -COMMA- denotes ,
T19379 5710-5712 NN denotes RA
T19378 5707-5709 IN denotes in
T19377 5701-5706 NN denotes IL-17
T19376 5698-5700 IN denotes of
T19375 5685-5697 NN denotes upregulation
T19374 5681-5684 DT denotes the
T19373 5678-5680 IN denotes of
T19372 5667-5677 NN denotes arbitrator
T19371 5657-5666 JJ denotes important
T19370 5654-5656 DT denotes an
T19369 5651-5653 VB denotes be
T19368 5645-5650 MD denotes could
T19367 5634-5644 NN denotes activation
T19366 5628-5633 NN denotes NF-κB
T19365 5618-5627 JJ denotes resultant
T19364 5614-5617 CC denotes and
T19363 5605-5613 NN denotes PI3K/Akt
T19362 5600-5604 IN denotes that
T19361 5587-5599 VB denotes demonstrated
T19360 5579-5586 RB denotes clearly
T19359 5574-5578 NN denotes data
T19358 5570-5573 PRP-DOLLAR- denotes Our
T19357 5561-5568 VB denotes lacking
T19356 5557-5560 VB denotes are
T19355 5551-5556 NN denotes IL-17
T19354 5542-5550 VB denotes inducing
T19353 5535-5541 NN denotes signal
T19352 5531-5534 DT denotes the
T19351 5528-5530 IN denotes on
T19350 5523-5527 NN denotes data
T19349 5519-5522 DT denotes the
T19348 5517-5518 -COMMA- denotes ,
T19347 5512-5517 NN denotes types
T19346 5507-5511 NN denotes cell
T19345 5502-5506 JJ denotes many
T19344 5499-5501 IN denotes in
T19343 5491-5498 NN denotes signals
T19342 5480-5490 VB denotes activating
T19341 5472-5479 VB denotes deliver
T19340 5469-5471 TO denotes to
T19339 5460-5468 VB denotes reported
T19338 5455-5459 VB denotes been
T19337 5450-5454 VB denotes have
T19336 5444-5449 NN denotes NF-κB
T19335 5439-5443 IN denotes with
T19334 5427-5438 NN denotes association
T19333 5424-5426 IN denotes in
T19332 5420-5423 NN denotes Akt
T19331 5413-5419 NN denotes kinase
T19330 5402-5412 JJ denotes downstream
T19329 5398-5401 PRP-DOLLAR- denotes its
T19328 5394-5397 CC denotes and
T19327 5389-5393 NN denotes PI3K
T19326 5380-5388 IN denotes Although
T19325 5377-5378 -RRB- denotes )
T19324 5372-5377 VB denotes shown
T19323 5368-5371 RB denotes not
T19322 5363-5367 NN denotes data
T19321 5362-5363 -LRB- denotes (
T19320 5350-5361 NN denotes experiments
T19319 5346-5349 PRP-DOLLAR- denotes our
T19318 5343-5345 IN denotes in
T19317 5333-5342 VB denotes activated
T19316 5329-5332 RB denotes not
T19315 5325-5328 VB denotes was
T19314 5323-5324 -COMMA- denotes ,
T19313 5303-5323 NN denotes cytokines/chemokines
T19312 5299-5302 IN denotes for
T19311 5291-5298 NN denotes pathway
T19310 5281-5290 NN denotes signaling
T19309 5271-5280 JJ denotes important
T19308 5263-5270 DT denotes another
T19307 5261-5262 -COMMA- denotes ,
T19306 5254-5261 NN denotes pathway
T19305 5241-5253 NN denotes transduction
T19304 5234-5240 NN denotes signal
T19303 5229-5233 NN denotes AP-1
T19302 5225-5228 DT denotes the
T19301 5223-5224 -COMMA- denotes ,
T19300 5215-5223 NN denotes contrast
T19299 5212-5214 IN denotes In
T19298 5206-5210 NN denotes PBMC
T19297 5203-5205 NN denotes RA
T19296 5200-5202 IN denotes in
T19295 5194-5199 NN denotes IL-17
T19294 5191-5193 IN denotes of
T19293 5181-5190 NN denotes induction
T19292 5177-5180 DT denotes the
T19291 5174-5176 IN denotes in
T19290 5165-5173 VB denotes involved
T19289 5156-5164 RB denotes actively
T19288 5151-5155 RB denotes also
T19287 5148-5150 VB denotes is
T19286 5140-5147 NN denotes pathway
T19285 5134-5139 NN denotes NF-κB
T19284 5130-5133 DT denotes the
T19283 5125-5129 IN denotes that
T19282 5118-5124 JJ denotes likely
T19281 5113-5117 RB denotes most
T19280 5110-5112 VB denotes is
T19279 5107-5109 PRP denotes it
T19278 5105-5106 -COMMA- denotes ,
T19277 5094-5105 NN denotes experiments
T19276 5090-5093 PRP-DOLLAR- denotes our
T19275 5087-5089 IN denotes in
T19274 5078-5086 NN denotes mitogens
T19273 5075-5077 CC denotes or
T19272 5069-5074 NN denotes IL-15
T19271 5067-5068 -COMMA- denotes ,
T19270 5049-5067 JJ denotes anti-CD3/anti-CD28
T19269 5046-5048 IN denotes by
T19268 5036-5045 VB denotes activated
T19267 5031-5035 RB denotes also
T19266 5027-5030 VB denotes was
T19265 5021-5026 NN denotes NF-κB
T19264 5016-5020 IN denotes that
T19263 5011-5015 NN denotes fact
T19262 5007-5010 DT denotes the
T19261 5004-5006 IN denotes of
T19260 4999-5003 NN denotes view
T19259 4996-4998 IN denotes In
T19258 4992-4994 NN denotes RA
T19257 4989-4991 IN denotes in
T19256 4983-4988 NN denotes IL-17
T19255 4980-4982 IN denotes of
T19254 4970-4979 NN denotes induction
T19253 4966-4969 DT denotes the
T19252 4963-4965 IN denotes in
T19251 4958-4962 NN denotes PI3K
T19250 4955-4957 IN denotes of
T19249 4943-4954 NN denotes involvement
T19248 4934-4942 JJ denotes possible
T19247 4930-4933 DT denotes the
T19246 4921-4929 VB denotes suggests
T19245 4909-4920 NN denotes stimulation
T19244 4900-4908 JJ denotes anti-CD3
T19243 4895-4899 IN denotes upon
T19242 4880-4894 VB denotes phosphorylated
T19241 4877-4879 VB denotes is
T19240 4873-4876 NN denotes Akt
T19239 4868-4872 IN denotes that
T19238 4863-4867 NN denotes fact
T19237 4859-4862 DT denotes The
T19236 4852-4857 NN denotes hours
T19235 4850-4851 CD denotes 2
T19234 4847-4849 IN denotes at
T19233 4838-4846 NN denotes activity
T19232 4835-4837 IN denotes of
T19231 4830-4834 NN denotes loss
T19230 4822-4829 JJ denotes gradual
T19229 4820-4821 DT denotes a
T19228 4816-4819 CC denotes and
T19227 4811-4815 NN denotes hour
T19226 4809-4810 CD denotes 1
T19225 4806-4808 IN denotes at
T19224 4795-4805 NN denotes activation
T19223 4791-4794 NN denotes Akt
T19222 4788-4790 IN denotes of
T19221 4779-4787 NN denotes response
T19220 4771-4778 JJ denotes maximal
T19219 4769-4770 DT denotes a
T19218 4764-4768 VB denotes have
T19217 4761-4763 TO denotes to
T19216 4754-4760 VB denotes seemed
T19215 4749-4753 NN denotes PI3K
T19214 4746-4748 IN denotes of
T19213 4738-4745 NN denotes pathway
T19212 4727-4737 JJ denotes downstream
T19211 4725-4726 DT denotes a
T19210 4721-4724 IN denotes for
T19209 4714-4720 NN denotes search
T19208 4710-4713 DT denotes The
T19207 4697-4708 NN denotes experiments
T19206 4690-4696 JJ denotes future
T19205 4687-4689 IN denotes in
T19204 4679-4686 VB denotes studied
T19203 4676-4678 VB denotes be
T19202 4673-4675 TO denotes to
T19201 4667-4672 VB denotes needs
T19200 4656-4666 NN denotes production
T19199 4650-4655 NN denotes IL-17
T19198 4646-4649 IN denotes for
T19197 4640-4645 NN denotes NF-κB
T19196 4636-4639 CC denotes and
T19195 4632-4635 NN denotes p38
T19194 4624-4631 IN denotes between
T19193 4611-4623 NN denotes relationship
T19192 4604-4610 JJ denotes direct
T19191 4600-4603 DT denotes The
T19190 4588-4598 NN denotes activation
T19189 4583-4587 NN denotes PI3K
T19188 4580-4582 IN denotes of
T19187 4568-4579 JJ denotes independent
T19186 4560-4567 NN denotes pathway
T19185 4555-4559 NN denotes MAPK
T19184 4551-4554 NN denotes p38
T19183 4549-4550 DT denotes a
T19182 4545-4548 IN denotes for
T19181 4536-4544 NN denotes evidence
T19180 4532-4535 DT denotes the
T19157 4387-4394 NN denotes results
T19156 4383-4386 PRP-DOLLAR- denotes Our
T19155 4380-4381 -RRB- denotes ]
T19154 4378-4380 CD denotes 33
T19153 4377-4378 -LRB- denotes [
T19152 4369-4376 NN denotes protein
T19151 4351-4368 JJ denotes p300/CREB-binding
T19150 4341-4350 NN denotes acetylase
T19149 4333-4340 NN denotes histone
T19148 4323-4332 VB denotes involving
T19147 4313-4322 NN denotes mechanism
T19146 4311-4312 DT denotes a
T19145 4308-4310 IN denotes by
T19144 4302-4307 NN denotes NF-κB
T19143 4292-4301 VB denotes stimulate
T19142 4288-4291 MD denotes can
T19141 4284-4287 NN denotes p38
T19140 4274-4283 VB denotes activated
T19139 4270-4273 DT denotes the
T19138 4266-4269 CC denotes and
T19137 4264-4265 -COMMA- denotes ,
T19136 4263-4264 -RRB- denotes ]
T19135 4261-4263 CD denotes 32
T19134 4260-4261 -LRB- denotes [
T19133 4256-4259 NN denotes p38
T19132 4253-4255 IN denotes by
T19131 4243-4252 VB denotes activated
T19130 4240-4242 VB denotes is
T19129 4231-4239 NN denotes kinase-β
T19128 4227-4230 NN denotes IκB
T19127 4225-4226 -COMMA- denotes ,
T19126 4217-4225 NN denotes myocytes
T19125 4214-4216 IN denotes In
T19124 4209-4212 NN denotes p38
T19123 4205-4208 CC denotes and
T19122 4199-4204 NN denotes NF-κB
T19121 4191-4198 IN denotes between
T19120 4181-4190 NN denotes crosstalk
T19119 4172-4180 VB denotes supports
T19118 4163-4171 NN denotes evidence
T19117 4160-4162 IN denotes of
T19116 4153-4159 NN denotes series
T19115 4151-4152 DT denotes a
T19114 4146-4150 IN denotes that
T19113 4134-4145 JJ denotes interesting
T19112 4131-4133 VB denotes is
T19111 4128-4130 PRP denotes It
T19110 4117-4126 NN denotes inhibitor
T19109 4112-4116 NN denotes MAPK
T19399 5827-5831 NN denotes PDTC
T19398 5824-5826 IN denotes by
T19397 5815-5823 NN denotes promoter
T19396 5809-5814 NN denotes IL-17
T19108 4108-4111 NN denotes p38
T19107 4106-4107 DT denotes a
T19106 4104-4105 -COMMA- denotes ,
T19105 4096-4104 NN denotes SB203580
T19104 4093-4095 IN denotes of
T19103 4084-4092 NN denotes addition
T19102 4080-4083 DT denotes the
T19101 4077-4079 IN denotes by
T19100 4063-4076 VB denotes downregulated
T19099 4059-4062 VB denotes was
T19098 4048-4058 NN denotes production
T19097 4042-4047 NN denotes IL-17
T19096 4025-4041 JJ denotes anti-CD3-induced
T19095 4020-4024 IN denotes that
T19094 4014-4019 VB denotes found
T19093 4009-4013 RB denotes also
T19092 4006-4008 PRP denotes We
T19091 3993-4004 NN denotes stimulation
T19090 3985-3992 IN denotes without
T19089 3974-3984 NN denotes production
T19088 3968-3973 JJ denotes basal
T19087 3965-3967 IN denotes of
T19086 3958-3964 NN denotes levels
T19085 3947-3957 JJ denotes comparable
T19084 3944-3946 TO denotes to
T19083 3939-3943 NN denotes PDTC
T19082 3929-3938 NN denotes inhibitor
T19081 3923-3928 NN denotes NF-κB
T19080 3919-3922 DT denotes the
T19079 3915-3918 CC denotes and
T19078 3906-3914 NN denotes LY294002
T19077 3896-3905 NN denotes inhibitor
T19076 3891-3895 NN denotes PI3K
T19075 3887-3890 DT denotes the
T19074 3884-3886 IN denotes by
T19073 3875-3883 VB denotes hampered
T19072 3861-3874 RB denotes significantly
T19071 3857-3860 VB denotes was
T19070 3852-3856 NN denotes PBMC
T19069 3849-3851 NN denotes RA
T19068 3846-3848 IN denotes in
T19067 3835-3845 NN denotes production
T19066 3829-3834 NN denotes IL-17
T19065 3812-3828 JJ denotes anti-CD3-induced
T19064 3807-3811 IN denotes that
T19063 3796-3806 VB denotes identified
T19062 3793-3795 PRP denotes We
T19061 3787-3791 NN denotes PBMC
T19060 3784-3786 NN denotes RA
T19059 3781-3783 IN denotes in
T19058 3775-3780 NN denotes IL-17
T19057 3772-3774 IN denotes of
T19056 3762-3771 NN denotes induction
T19055 3758-3761 DT denotes the
T19054 3755-3757 IN denotes in
T19053 3746-3754 VB denotes involved
T19052 3739-3745 RB denotes mainly
T19051 3735-3738 VB denotes was
T19050 3727-3734 NN denotes pathway
T19049 3717-3726 NN denotes signaling
T19048 3711-3716 WDT denotes which
T19047 3702-3710 VB denotes examined
T19046 3692-3701 RB denotes therefore
T19045 3689-3691 PRP denotes we
T19044 3687-3688 -COMMA- denotes ,
T19043 3677-3687 NN denotes inhibitors
T19042 3664-3676 NN denotes transduction
T19041 3657-3663 NN denotes signal
T19040 3651-3656 VB denotes using
T19039 3648-3650 IN denotes By
T19038 3638-3646 NN denotes pathways
T19037 3628-3637 NN denotes signaling
T19036 3620-3627 JJ denotes certain
T19035 3617-3619 IN denotes by
T19034 3607-3616 VB denotes regulated
T19033 3604-3606 VB denotes be
T19032 3600-3603 MD denotes can
T19031 3589-3599 NN denotes production
T19030 3583-3588 NN denotes IL-17
T19029 3579-3582 WRB denotes how
T19028 3576-3578 IN denotes on
T19027 3566-3575 JJ denotes available
T19026 3561-3565 VB denotes been
T19025 3556-3560 VB denotes have
T19024 3551-3555 NN denotes data
T19023 3548-3550 DT denotes no
T19022 3546-3547 -COMMA- denotes ,
T19021 3545-3546 -RRB- denotes ]
T19020 3538-3545 CD denotes 8,30,31
T19019 3537-3538 -LRB- denotes [
T19018 3530-3536 RB denotes widely
T19017 3519-3529 VB denotes documented
T19016 3514-3518 VB denotes been
T19015 3510-3513 VB denotes has
T19014 3504-3509 NN denotes IL-17
T19013 3501-3503 IN denotes by
T19012 3480-3500 NN denotes cytokines/chemokines
T19011 3477-3479 IN denotes of
T19010 3467-3476 NN denotes induction
T19009 3463-3466 DT denotes the
T19008 3459-3462 IN denotes for
T19007 3451-3458 NN denotes pathway
T19006 3441-3450 NN denotes signaling
T19005 3437-3440 DT denotes the
T19004 3428-3436 IN denotes Although
T19003 3422-3426 NN denotes PBMC
T19002 3419-3421 NN denotes RA
T19001 3416-3418 IN denotes in
T19000 3406-3415 NN denotes induction
T18999 3400-3405 NN denotes IL-17
T18998 3390-3399 VB denotes increases
T18997 3385-3389 RB denotes also
T18996 3366-3384 JJ denotes anti-CD3/anti-CD28
T18995 3358-3365 IN denotes through
T18994 3347-3357 NN denotes activation
T18993 3342-3346 NN denotes cell
T18992 3340-3341 NN denotes T
T18991 3338-3339 -COMMA- denotes ,
T18990 3337-3338 -RRB- denotes ]
T18989 3335-3337 CD denotes 25
T18988 3334-3335 -LRB- denotes [
T18987 3322-3333 NN denotes individuals
T18986 3315-3321 JJ denotes normal
T18985 3311-3314 IN denotes for
T18984 3302-3310 VB denotes reported
T18983 3299-3301 IN denotes As
T18982 3289-3297 NN denotes cultures
T18981 3284-3288 NN denotes PBMC
T18980 3281-3283 IN denotes in
T18979 3259-3280 NN denotes monocytes/macrophages
T18978 3256-3258 IN denotes of
T18977 3245-3255 NN denotes activation
T18976 3241-3244 DT denotes the
T18975 3233-3240 IN denotes through
T18974 3227-3232 NN denotes cells
T18973 3225-3226 NN denotes T
T18972 3222-3224 IN denotes on
T18971 3211-3221 RB denotes indirectly
T18970 3203-3210 NN denotes effects
T18969 3197-3202 VB denotes exert
T18968 3191-3196 MD denotes might
T18967 3188-3190 PRP denotes it
T18966 3186-3187 -COMMA- denotes ,
T18965 3176-3186 NN denotes activation
T18964 3171-3175 NN denotes cell
T18963 3169-3170 NN denotes T
T18962 3161-3168 VB denotes induces
T18961 3152-3160 RB denotes directly
T18960 3146-3151 NN denotes MCP-1
T18959 3141-3145 IN denotes that
T18958 3136-3140 NN denotes data
T18957 3133-3135 DT denotes no
T18956 3128-3132 VB denotes were
T18955 3122-3127 EX denotes there
T18954 3113-3121 IN denotes Although
T18953 3110-3111 -RRB- denotes ]
T18952 3108-3110 CD denotes 13
T18951 3107-3108 -LRB- denotes [
T18950 3104-3106 RB denotes so
T18949 3101-3103 VB denotes do
T18948 3097-3100 RB denotes not
T18947 3093-3096 VB denotes did
T18946 3087-3092 NN denotes TNF-α
T18945 3083-3086 CC denotes but
T18944 3081-3082 -COMMA- denotes ,
T18943 3077-3081 NN denotes PBMC
T18942 3074-3076 IN denotes in
T18836 2428-2437 RB denotes therefore
T18835 2425-2427 PRP denotes We
T18834 2422-2423 -RRB- denotes ]
T18833 2417-2422 CD denotes 13,14
T18832 2416-2417 -LRB- denotes [
T18831 2405-2415 NN denotes production
T18830 2399-2404 NN denotes IL-17
T18829 2390-2398 VB denotes regulate
T18828 2387-2389 TO denotes to
T18827 2381-2386 VB denotes known
T18826 2376-2380 VB denotes been
T18825 2371-2375 VB denotes have
T18824 2369-2370 -RRB- denotes )
T18823 2364-2369 NN denotes IL-23
T18822 2360-2363 CC denotes and
T18821 2354-2359 NN denotes IL-15
T18820 2353-2354 -LRB- denotes (
T18819 2343-2352 NN denotes cytokines
T18818 2338-2342 DT denotes some
T18817 2329-2337 IN denotes although
T18816 2327-2328 -COMMA- denotes ,
T18815 2325-2327 NN denotes RA
T18814 2322-2324 IN denotes in
T18813 2311-2321 NN denotes production
T18812 2305-2310 NN denotes IL-17
T18811 2295-2304 VB denotes stimulate
T18810 2290-2294 WDT denotes that
T18809 2283-2289 NN denotes agents
T18808 2279-2282 DT denotes the
T18807 2276-2278 IN denotes on
T18806 2266-2275 JJ denotes available
T18805 2261-2265 NN denotes data
T18804 2257-2260 JJ denotes few
T18803 2253-2256 RB denotes yet
T18802 2250-2252 RB denotes as
T18801 2246-2249 VB denotes are
T18800 2240-2245 EX denotes There
T18799 2237-2238 -RRB- denotes ]
T18798 2229-2237 CD denotes 12,28,29
T18797 2228-2229 -LRB- denotes [
T18796 2222-2227 FW denotes vitro
T18795 2219-2221 FW denotes in
T18794 2216-2218 NN denotes E2
T18793 2202-2215 NN denotes prostaglandin
T18792 2199-2201 IN denotes as
T18791 2194-2198 RB denotes well
T18790 2191-2193 RB denotes as
T18789 2189-2190 CD denotes 6
T18788 2184-2188 NN denotes gene
T19179 4523-4531 VB denotes provided
T19178 4517-4522 WDT denotes which
T19177 4515-4516 -COMMA- denotes ,
T19176 4507-4515 NN denotes LY294002
T19175 4504-4506 IN denotes by
T19174 4494-4503 VB denotes decreased
T19173 4490-4493 VB denotes was
T19172 4481-4489 NN denotes activity
T19171 4473-4480 NN denotes binding
T19170 4467-4472 NN denotes NF-κB
T19169 4459-4466 IN denotes whereas
T19168 4457-4458 -COMMA- denotes ,
T19167 4449-4457 NN denotes LY294002
T19166 4446-4448 IN denotes by
T19165 4437-4445 VB denotes affected
T19164 4433-4436 RB denotes not
T19163 4429-4432 VB denotes was
T19162 4418-4428 NN denotes activation
T19161 4413-4417 NN denotes MAPK
T19160 4409-4412 NN denotes p38
T19159 4404-4408 IN denotes that
T19158 4395-4403 VB denotes revealed
T18787 2166-2183 JJ denotes factor-stimulated
T18786 2157-2165 NN denotes necrosis
T18785 2151-2156 NN denotes tumor
T18784 2147-2150 CC denotes and
T18783 2142-2146 NN denotes IL-8
T18782 2140-2141 -COMMA- denotes ,
T18781 2136-2140 NN denotes IL-6
T18780 2133-2135 IN denotes as
T18779 2128-2132 JJ denotes such
T18778 2118-2127 NN denotes cytokines
T18777 2110-2117 JJ denotes several
T18776 2102-2109 VB denotes secrete
T18775 2099-2101 TO denotes to
T18774 2086-2098 NN denotes synoviocytes
T18773 2075-2085 JJ denotes rheumatoid
T18772 2064-2074 VB denotes stimulates
T18771 2058-2063 NN denotes IL-17
T18770 2056-2057 -COMMA- denotes ,
T18769 2049-2056 NN denotes example
T18768 2045-2048 IN denotes For
T18767 2037-2043 NN denotes joints
T18766 2033-2036 DT denotes the
T18765 2030-2032 IN denotes in
T18764 2024-2029 NN denotes cells
T18763 2018-2023 JJ denotes other
T18762 2009-2017 VB denotes activate
T18761 2004-2008 RB denotes also
T18760 1998-2003 WDT denotes which
T18759 1996-1997 -COMMA- denotes ,
T18758 1986-1996 NN denotes chemokines
T18757 1982-1985 CC denotes and
T18756 1972-1981 NN denotes cytokines
T18755 1956-1971 JJ denotes proinflammatory
T18754 1953-1955 IN denotes of
T18753 1945-1952 NN denotes variety
T18752 1943-1944 DT denotes a
T18751 1935-1942 VB denotes produce
T18750 1929-1934 MD denotes might
T18749 1922-1928 NN denotes joints
T18748 1919-1921 NN denotes RA
T18747 1910-1918 JJ denotes inflamed
T18746 1907-1909 IN denotes in
T18745 1901-1906 NN denotes cells
T18744 1893-1900 IN denotes between
T18743 1881-1892 NN denotes interaction
T18742 1873-1880 JJ denotes complex
T18741 1871-1872 DT denotes A
T18740 1868-1869 -RRB- denotes ]
T18739 1866-1868 CD denotes 27
T18738 1865-1866 -LRB- denotes [
T18737 1859-1864 NN denotes model
T18736 1849-1858 NN denotes arthritis
T18735 1832-1848 JJ denotes collagen-induced
T18734 1830-1831 DT denotes a
T18733 1827-1829 IN denotes in
T18732 1818-1826 NN denotes collagen
T18731 1815-1817 CD denotes II
T18730 1810-1814 NN denotes type
T18729 1798-1809 VB denotes recognizing
T18728 1792-1797 NN denotes cells
T18727 1790-1791 NN denotes T
T18726 1787-1789 IN denotes by
T18725 1777-1786 VB denotes augmented
T18724 1763-1776 RB denotes significantly
T18723 1759-1762 VB denotes was
T18722 1748-1758 NN denotes production
T18721 1742-1747 NN denotes IL-17
T18720 1740-1741 -COMMA- denotes ,
T18719 1732-1740 NN denotes addition
T18718 1729-1731 IN denotes In
T18717 1726-1727 -RRB- denotes ]
T18716 1724-1726 CD denotes 14
T18715 1723-1724 -LRB- denotes [
T18714 1713-1722 NN denotes infection
T18713 1703-1712 JJ denotes pulmonary
T18712 1689-1702 JJ denotes Gram-negative
T18711 1686-1688 IN denotes in
T18710 1676-1685 NN denotes mechanism
T18709 1665-1675 NN denotes triggering
T18708 1659-1664 NN denotes IL-23
T18707 1656-1658 DT denotes an
T18706 1652-1655 IN denotes via
T18705 1646-1651 NN denotes cells
T18704 1644-1645 NN denotes T
T18703 1639-1643 JJ denotes CD8+
T18702 1636-1638 IN denotes by
T18701 1627-1635 VB denotes produced
T18700 1624-1626 VB denotes be
T18699 1619-1623 RB denotes also
T18698 1615-1618 MD denotes can
T18697 1612-1614 PRP denotes it
T18696 1610-1611 -COMMA- denotes ,
T18695 1603-1610 RB denotes However
T18694 1600-1601 -RRB- denotes ]
T18693 1598-1600 CD denotes 26
T18692 1597-1598 -LRB- denotes [
T18691 1587-1596 NN denotes phenotype
T18690 1583-1586 NN denotes Th2
T18689 1579-1582 DT denotes the
T18688 1575-1578 RB denotes not
T18687 1573-1574 -COMMA- denotes ,
T18686 1568-1573 NN denotes cells
T18685 1560-1567 NN denotes Th1/Th0
T18684 1556-1559 IN denotes for
T18683 1545-1555 RB denotes especially
T18682 1543-1544 -COMMA- denotes ,
T18681 1538-1543 NN denotes cells
T18680 1536-1537 NN denotes T
T18679 1531-1535 JJ denotes CD4+
T18678 1521-1530 VB denotes activated
T18677 1518-1520 IN denotes by
T18676 1511-1517 RB denotes mainly
T18675 1502-1510 VB denotes produced
T18674 1499-1501 VB denotes is
T18673 1493-1498 NN denotes IL-17
T18672 1478-1491 NN denotes proliferation
T18671 1469-1477 JJ denotes cellular
T18670 1466-1468 TO denotes to
T18669 1461-1465 IN denotes than
T18668 1454-1460 RB denotes rather
T18667 1445-1453 NN denotes activity
T18666 1436-1444 JJ denotes cellular
T18665 1426-1435 VB denotes increased
T18664 1423-1425 TO denotes to
T18663 1419-1422 JJ denotes due
T18662 1416-1418 VB denotes be
T18661 1410-1415 MD denotes might
T18660 1404-1409 NN denotes IL-17
T18659 1401-1403 IN denotes of
T18658 1388-1400 NN denotes upregulation
T18657 1383-1387 DT denotes this
T18656 1378-1382 IN denotes that
T18655 1376-1377 -COMMA- denotes ,
T18654 1375-1376 -RRB- denotes )
T18653 1370-1375 VB denotes shown
T18652 1366-1369 RB denotes not
T18651 1361-1365 NN denotes data
T18650 1360-1361 -LRB- denotes (
T18649 1354-1359 NN denotes assay
T18648 1340-1353 NN denotes proliferation
T18647 1335-1339 NN denotes cell
T18646 1333-1334 DT denotes a
T18645 1330-1332 IN denotes by
T18644 1328-1329 -COMMA- denotes ,
T18643 1323-1328 VB denotes found
T18642 1320-1322 PRP denotes We
T18641 1312-1318 NN denotes manner
T18640 1297-1311 JJ denotes dose-dependent
T18639 1295-1296 DT denotes a
T18638 1292-1294 IN denotes in
T18637 1287-1291 NN denotes PBMC
T18636 1284-1286 NN denotes RA
T18635 1279-1283 IN denotes from
T18634 1268-1278 NN denotes production
T18633 1262-1267 NN denotes IL-17
T18632 1252-1261 VB denotes increased
T18631 1250-1251 -COMMA- denotes ,
T18630 1242-1250 NN denotes receptor
T18629 1237-1241 NN denotes cell
T18628 1235-1236 NN denotes T
T18627 1231-1234 DT denotes the
T18626 1223-1230 IN denotes through
T18625 1213-1222 NN denotes signaling
T18624 1209-1212 IN denotes for
T18623 1190-1208 JJ denotes anti-CD3/anti-CD28
T18622 1187-1189 IN denotes as
T18621 1182-1186 RB denotes well
T18576 925-932 RB denotes However
T18575 922-923 -RRB- denotes ]
T18574 920-922 CD denotes 15
T18573 919-920 -LRB- denotes [
T18572 913-918 NN denotes fluid
T18571 904-912 JJ denotes synovial
T18570 901-903 NN denotes OA
T18569 898-900 IN denotes in
T18568 893-897 IN denotes than
T18567 887-892 NN denotes fluid
T18566 878-886 JJ denotes synovial
T18565 875-877 NN denotes RA
T18564 872-874 IN denotes in
T18563 865-871 JJ denotes higher
T18562 862-864 VB denotes be
T18561 859-861 TO denotes to
T18560 853-858 VB denotes found
T18559 848-852 VB denotes were
T18558 842-847 NN denotes IL-17
T18557 839-841 IN denotes of
T18556 832-838 NN denotes Levels
T18555 826-830 VB denotes used
T18554 823-825 PRP denotes it
T18553 815-822 NN denotes pathway
T18552 805-814 NN denotes signaling
T18551 799-804 WDT denotes which
T18550 795-798 CC denotes and
T18549 793-794 -COMMA- denotes ,
T18548 789-793 NN denotes PBMC
T18547 786-788 NN denotes RA
T18546 783-785 IN denotes in
T18545 773-782 VB denotes regulated
T18544 770-772 VB denotes is
T18543 759-769 NN denotes production
T18542 753-758 NN denotes IL-17
T18541 749-752 WRB denotes how
T18540 740-748 VB denotes evaluate
T18539 737-739 TO denotes to
T18538 731-736 VB denotes tried
T18537 728-730 PRP denotes we
T18536 726-727 -COMMA- denotes ,
T18535 719-726 NN denotes studies
T18534 715-718 PRP-DOLLAR- denotes our
T18533 712-714 IN denotes In
T18532 700-710 NN denotes properties
T18531 684-699 JJ denotes proinflammatory
T18530 679-683 IN denotes with
T18529 670-678 NN denotes cytokine
T18528 657-669 JJ denotes cell-derived
T18941 3063-3073 NN denotes production
T18940 3057-3062 NN denotes IL-17
T18939 3051-3056 FW denotes vitro
T18938 3048-3050 FW denotes in
T18937 3038-3047 VB denotes triggered
T18936 3032-3037 NN denotes IL-15
T18935 3027-3031 IN denotes that
T18934 3020-3026 NN denotes report
T18933 3013-3019 JJ denotes recent
T18932 3011-3012 DT denotes a
T18931 3006-3010 IN denotes with
T18930 2995-3005 JJ denotes consistent
T18929 2990-2994 VB denotes were
T18928 2985-2989 NN denotes data
T18927 2981-2984 PRP-DOLLAR- denotes Our
T18926 2969-2979 NN denotes production
T18925 2963-2968 NN denotes IL-17
T18924 2956-2962 VB denotes affect
T18923 2952-2955 RB denotes not
T18922 2948-2951 VB denotes did
T18921 2946-2947 -COMMA- denotes ,
T18920 2940-2946 NN denotes joints
T18919 2937-2939 NN denotes RA
T18918 2934-2936 IN denotes in
T18917 2924-2933 VB denotes increased
T18916 2921-2923 VB denotes be
T18915 2918-2920 TO denotes to
T18914 2914-2917 CC denotes and
T18913 2903-2913 NN denotes properties
T18912 2887-2902 JJ denotes proinflammatory
T18911 2882-2886 VB denotes have
T18910 2879-2881 TO denotes to
T18909 2873-2878 VB denotes known
T18908 2869-2872 VB denotes are
T18907 2863-2868 WDT denotes which
T18906 2861-2862 -COMMA- denotes ,
T18905 2856-2861 NN denotes TNF-α
T18904 2852-2855 CC denotes and
T18903 2847-2851 NN denotes IL-1
T18902 2845-2846 -COMMA- denotes ,
T18901 2837-2845 NN denotes contrast
T18900 2834-2836 IN denotes In
T18899 2824-2832 RB denotes markedly
T18898 2819-2823 RB denotes more
T18897 2808-2818 NN denotes production
T18896 2802-2807 NN denotes IL-17
T18895 2792-2801 VB denotes augmented
T18894 2783-2791 NN denotes ligation
T18893 2779-2782 NN denotes TCR
T18892 2776-2778 TO denotes to
T18891 2770-2775 NN denotes MCP-1
T18890 2767-2769 CC denotes or
T18889 2761-2766 NN denotes IL-15
T18888 2754-2760 VB denotes Adding
T18887 2748-2752 NN denotes PBMC
T18886 2745-2747 NN denotes RA
T18885 2742-2744 IN denotes in
T18884 2736-2741 NN denotes IL-17
T18883 2733-2735 IN denotes of
T18882 2722-2732 NN denotes production
T18881 2718-2721 DT denotes the
T18880 2708-2717 VB denotes increased
T18879 2694-2707 RB denotes significantly
T18878 2685-2693 NN denotes ligation
T18877 2681-2684 NN denotes TCR
T18876 2678-2680 IN denotes as
T18875 2673-2677 RB denotes well
T18874 2670-2672 RB denotes as
T18873 2664-2669 NN denotes MCP-1
T18872 2660-2663 CC denotes and
T18871 2654-2659 NN denotes IL-15
T18870 2649-2653 IN denotes that
T18869 2636-2648 VB denotes demonstrated
T18868 2628-2635 NN denotes studies
T18867 2624-2627 PRP-DOLLAR- denotes Our
T18866 2604-2622 JJ denotes anti-CD3/anti-CD28
T18865 2598-2603 VB denotes using
T18864 2589-2597 NN denotes ligation
T18863 2587-2588 -RRB- denotes )
T18862 2584-2587 NN denotes TCR
T18861 2583-2584 -LRB- denotes (
T18860 2574-2582 NN denotes receptor
T18859 2569-2573 NN denotes cell
T18858 2567-2568 NN denotes T
T18857 2564-2566 IN denotes as
T18856 2559-2563 RB denotes well
T18855 2556-2558 RB denotes as
T18854 2547-2555 NN denotes mitogens
T18853 2543-2546 CC denotes and
T18852 2522-2542 NN denotes cytokines/chemokines
T18851 2519-2521 IN denotes of
T18850 2511-2518 NN denotes variety
T18849 2509-2510 DT denotes a
T18848 2506-2508 TO denotes to
T18847 2495-2505 VB denotes responding
T18846 2490-2494 NN denotes PBMC
T18845 2487-2489 NN denotes RA
T18844 2484-2486 IN denotes in
T18843 2478-2483 NN denotes IL-17
T18842 2475-2477 IN denotes of
T18841 2464-2474 NN denotes production
T18840 2458-2463 FW denotes vitro
T18839 2455-2457 FW denotes in
T18838 2451-2454 DT denotes the
T18837 2438-2450 VB denotes investigated
T18527 655-656 NN denotes T
T18526 653-654 DT denotes a
T18525 650-652 IN denotes as
T18524 640-649 VB denotes described
T18523 635-639 VB denotes been
T18522 631-634 VB denotes has
T18521 628-630 PRP denotes it
T18520 620-627 IN denotes because
T18519 610-619 VB denotes appealing
T18518 607-609 VB denotes is
T18517 601-606 NN denotes IL-17
T18516 599-600 -COMMA- denotes ,
T18515 592-599 NN denotes respect
T18514 587-591 DT denotes this
T18513 584-586 IN denotes In
T18512 572-582 NN denotes importance
T18511 568-571 PRP-DOLLAR- denotes its
T18510 560-567 VB denotes limited
T18509 556-559 VB denotes has
T18508 546-555 NN denotes cytokines
T18507 533-545 JJ denotes cell-derived
T18506 531-532 NN denotes T
T18505 528-530 IN denotes of
T18504 523-527 NN denotes lack
T18503 519-522 DT denotes the
T18502 517-518 -COMMA- denotes ,
T18501 505-517 NN denotes inflammation
T18500 496-504 JJ denotes synovial
T18499 485-495 JJ denotes rheumatoid
T18498 482-484 IN denotes of
T18497 469-481 NN denotes augmentation
T18496 465-468 DT denotes the
T18495 462-464 IN denotes in
T18494 457-461 NN denotes role
T18493 455-456 DT denotes a
T18492 450-454 VB denotes have
T18491 446-449 MD denotes may
T18490 440-445 NN denotes cells
T18489 438-439 NN denotes T
T18488 429-437 IN denotes Although
T18487 426-427 -RRB- denotes ]
T18486 424-426 CD denotes 24
T18485 423-424 -LRB- denotes [
T18484 414-422 NN denotes synovium
T18483 411-413 NN denotes RA
T18482 408-410 IN denotes in
T18481 401-407 VB denotes detect
T18480 398-400 TO denotes to
T18479 388-397 JJ denotes difficult
T18478 381-387 VB denotes proved
T18477 375-380 RB denotes often
T18476 370-374 VB denotes have
T18475 368-369 -COMMA- denotes ,
T18474 356-368 NN denotes interferon-γ
T18473 352-355 CC denotes and
T18472 347-351 NN denotes IL-4
T18471 336-346 RB denotes especially
T18470 334-335 -COMMA- denotes ,
T18469 325-334 NN denotes cytokines
T18468 312-324 JJ denotes cell-derived
T18467 310-311 NN denotes T
T18466 306-309 DT denotes the
T18465 298-305 IN denotes whereas
T18464 296-297 -COMMA- denotes ,
T18463 288-296 NN denotes synovium
T18462 277-287 JJ denotes rheumatoid
T18461 274-276 IN denotes in
T18460 265-273 JJ denotes abundant
T18459 261-264 VB denotes are
T18458 255-260 NN denotes TNF-α
T18457 251-254 CC denotes and
T18456 246-250 NN denotes IL-1
T18455 243-245 IN denotes as
T18454 238-242 JJ denotes such
T18453 228-237 NN denotes cytokines
T18452 212-227 JJ denotes Proinflammatory
T18451 209-210 -RRB- denotes ]
T18450 207-209 CD denotes 23
T18449 206-207 -LRB- denotes [
T18448 200-205 NN denotes cells
T18447 188-199 JJ denotes mononuclear
T18446 185-187 IN denotes by
T18445 172-184 NN denotes infiltration
T18444 164-171 JJ denotes intense
T18443 161-163 DT denotes an
T18442 157-160 CC denotes and
T18441 151-156 NN denotes cells
T18440 144-150 JJ denotes lining
T18439 135-143 JJ denotes synovial
T18438 132-134 IN denotes of
T18437 120-131 NN denotes hyperplasia
T18436 117-119 IN denotes by
T18435 103-116 VB denotes characterized
T18434 100-102 VB denotes is
T18433 97-99 NN denotes RA
T18432 94-95 -RRB- denotes ]
T18431 90-94 CD denotes 5,22
T18430 89-90 -LRB- denotes [
T18429 78-88 NN denotes properties
T18428 62-77 JJ denotes proinflammatory
T18427 57-61 IN denotes with
T18426 49-56 NN denotes product
T18425 44-48 NN denotes cell
T18424 42-43 NN denotes T
T18423 40-41 DT denotes a
T18422 37-39 IN denotes as
T18421 27-36 VB denotes described
T18420 21-26 RB denotes first
T18419 17-20 VB denotes was
T18418 11-16 NN denotes IL-17
T18620 1179-1181 RB denotes as
T18619 1177-1178 -COMMA- denotes ,
T18618 1169-1177 NN denotes mitogens
T18617 1166-1168 IN denotes as
T18616 1162-1165 NN denotes PHA
T18615 1160-1161 -COMMA- denotes ,
T18614 1149-1160 NN denotes experiments
T18613 1145-1148 PRP-DOLLAR- denotes our
T18612 1142-1144 IN denotes In
T18611 1139-1140 -RRB- denotes ]
T18610 1137-1139 CD denotes 25
T18609 1136-1137 -LRB- denotes [
T18608 1124-1135 NN denotes individuals
T18607 1116-1123 JJ denotes healthy
T18606 1113-1115 IN denotes in
T18605 1101-1112 NN denotes stimulation
T18604 1082-1100 JJ denotes anti-CD3/anti-CD28
T18603 1079-1081 IN denotes by
T18602 1070-1078 VB denotes achieved
T18601 1067-1069 VB denotes be
T18600 1063-1066 MD denotes can
T18599 1052-1062 NN denotes production
T18598 1046-1051 NN denotes IL-17
T18597 1043-1045 IN denotes of
T18596 1037-1042 NN denotes level
T18595 1029-1036 JJ denotes highest
T18594 1025-1028 DT denotes the
T18593 1016-1024 IN denotes although
T18592 1014-1015 -COMMA- denotes ,
T18591 1012-1014 NN denotes RA
T18590 1009-1011 IN denotes in
T18589 998-1008 NN denotes production
T18588 992-997 NN denotes IL-17
T18587 982-991 VB denotes stimulate
T18586 977-981 WDT denotes that
T18585 970-976 NN denotes agents
T18584 966-969 DT denotes the
T18583 963-965 IN denotes on
T18582 953-962 JJ denotes available
T18581 948-952 NN denotes data
T18580 944-947 JJ denotes few
T18579 940-943 VB denotes are
T18578 934-939 EX denotes there
T18577 932-933 -COMMA- denotes ,
R9423 T18418 T18419 arg1Of IL-17,was
R9424 T18418 T18421 arg2Of IL-17,described
R9425 T18421 T18419 arg2Of described,was
R9426 T18421 T18420 arg1Of described,first
R9427 T18421 T18422 arg1Of described,as
R9428 T18426 T18422 arg2Of product,as
R9429 T18426 T18423 arg1Of product,a
R9430 T18426 T18424 arg1Of product,T
R9431 T18426 T18425 arg1Of product,cell
R9432 T18426 T18427 arg1Of product,with
R9433 T18429 T18427 arg2Of properties,with
R9434 T18429 T18428 arg1Of properties,proinflammatory
R9435 T18429 T18430 arg1Of properties,[
R9436 T18431 T18430 arg2Of "5,22",[
R9437 T18432 T18430 arg3Of ],[
R9438 T18433 T18434 arg1Of RA,is
R9439 T18433 T18435 arg2Of RA,characterized
R9440 T18435 T18434 arg2Of characterized,is
R9441 T18435 T18449 arg1Of characterized,[
R9442 T18437 T18438 arg1Of hyperplasia,of
R9443 T18437 T18442 arg1Of hyperplasia,and
R9444 T18441 T18438 arg2Of cells,of
R9445 T18441 T18439 arg1Of cells,synovial
R9446 T18441 T18440 arg1Of cells,lining
R9447 T18442 T18435 arg1Of and,characterized
R9448 T18442 T18436 arg2Of and,by
R9449 T18445 T18442 arg2Of infiltration,and
R9450 T18445 T18443 arg1Of infiltration,an
R9451 T18445 T18444 arg1Of infiltration,intense
R9452 T18445 T18446 arg1Of infiltration,by
R9453 T18448 T18446 arg2Of cells,by
R9454 T18448 T18447 arg1Of cells,mononuclear
R9455 T18450 T18449 arg2Of 23,[
R9456 T18451 T18449 arg3Of ],[
R9457 T18453 T18452 arg1Of cytokines,Proinflammatory
R9458 T18453 T18455 arg1Of cytokines,as
R9459 T18453 T18459 arg1Of cytokines,are
R9460 T18453 T18460 arg1Of cytokines,abundant
R9461 T18455 T18454 arg1Of as,such
R9462 T18456 T18457 arg1Of IL-1,and
R9463 T18457 T18455 arg2Of and,as
R9464 T18458 T18457 arg2Of TNF-α,and
R9465 T18459 T18465 arg1Of are,whereas
R9466 T18460 T18459 arg2Of abundant,are
R9467 T18460 T18461 arg1Of abundant,in
R9468 T18463 T18461 arg2Of synovium,in
R9469 T18463 T18462 arg1Of synovium,rheumatoid
R9470 T18465 T18464 arg1Of whereas,","
R9471 T18468 T18467 arg1Of cell-derived,T
R9472 T18469 T18466 arg1Of cytokines,the
R9473 T18469 T18468 arg1Of cytokines,cell-derived
R9474 T18469 T18470 arg1Of cytokines,","
R9475 T18469 T18476 arg1Of cytokines,have
R9476 T18469 T18478 arg1Of cytokines,proved
R9477 T18469 T18479 arg1Of cytokines,difficult
R9478 T18469 T18481 arg2Of cytokines,detect
R9479 T18472 T18473 arg1Of IL-4,and
R9480 T18473 T18470 arg2Of and,","
R9481 T18473 T18471 arg1Of and,especially
R9482 T18474 T18473 arg2Of interferon-γ,and
R9483 T18478 T18465 arg2Of proved,whereas
R9484 T18478 T18475 arg1Of proved,","
R9485 T18478 T18476 arg2Of proved,have
R9486 T18478 T18477 arg1Of proved,often
R9487 T18479 T18478 arg2Of difficult,proved
R9488 T18481 T18479 arg2Of detect,difficult
R9489 T18481 T18480 arg1Of detect,to
R9490 T18481 T18482 arg1Of detect,in
R9491 T18481 T18485 arg1Of detect,[
R9492 T18484 T18482 arg2Of synovium,in
R9493 T18484 T18483 arg1Of synovium,RA
R9494 T18486 T18485 arg2Of 24,[
R9495 T18487 T18485 arg3Of ],[
R9496 T18490 T18489 arg1Of cells,T
R9497 T18490 T18491 arg1Of cells,may
R9498 T18490 T18492 arg1Of cells,have
R9499 T18492 T18488 arg2Of have,Although
R9500 T18492 T18491 arg2Of have,may
R9501 T18492 T18495 arg1Of have,in
R9502 T18494 T18492 arg2Of role,have
R9503 T18494 T18493 arg1Of role,a
R9504 T18497 T18495 arg2Of augmentation,in
R9505 T18497 T18496 arg1Of augmentation,the
R9506 T18497 T18498 arg1Of augmentation,of
R9507 T18501 T18498 arg2Of inflammation,of
R9508 T18501 T18499 arg1Of inflammation,rheumatoid
R9509 T18501 T18500 arg1Of inflammation,synovial
R9510 T18504 T18503 arg1Of lack,the
R9511 T18504 T18505 arg1Of lack,of
R9512 T18504 T18509 arg1Of lack,has
R9513 T18504 T18510 arg1Of lack,limited
R9514 T18508 T18505 arg2Of cytokines,of
R9515 T18508 T18506 arg1Of cytokines,T
R9516 T18508 T18507 arg1Of cytokines,cell-derived
R9517 T18510 T18488 arg1Of limited,Although
R9518 T18510 T18502 arg1Of limited,","
R9519 T18510 T18509 arg2Of limited,has
R9520 T18512 T18510 arg2Of importance,limited
R9521 T18512 T18511 arg1Of importance,its
R9522 T18515 T18513 arg2Of respect,In
R9523 T18515 T18514 arg1Of respect,this
R9524 T18517 T18518 arg1Of IL-17,is
R9525 T18517 T18519 arg1Of IL-17,appealing
R9526 T18519 T18513 arg1Of appealing,In
R9527 T18519 T18516 arg1Of appealing,","
R9528 T18519 T18518 arg2Of appealing,is
R9529 T18519 T18520 arg1Of appealing,because
R9530 T18521 T18522 arg1Of it,has
R9531 T18521 T18523 arg1Of it,been
R9532 T18521 T18524 arg2Of it,described
R9533 T18524 T18520 arg2Of described,because
R9534 T18524 T18522 arg2Of described,has
R9535 T18524 T18523 arg2Of described,been
R9536 T18524 T18525 arg1Of described,as
R9537 T18529 T18525 arg2Of cytokine,as
R9538 T18529 T18526 arg1Of cytokine,a
R9539 T18529 T18527 arg1Of cytokine,T
R9540 T18529 T18528 arg1Of cytokine,cell-derived
R9541 T18529 T18530 arg1Of cytokine,with
R9542 T18532 T18530 arg2Of properties,with
R9543 T18532 T18531 arg1Of properties,proinflammatory
R9544 T18535 T18533 arg2Of studies,In
R9545 T18535 T18534 arg1Of studies,our
R9546 T18537 T18538 arg1Of we,tried
R9547 T18537 T18540 arg1Of we,evaluate
R9548 T18538 T18533 arg1Of tried,In
R9549 T18538 T18536 arg1Of tried,","
R9550 T18538 T18550 arg1Of tried,and
R9551 T18540 T18538 arg2Of evaluate,tried
R9552 T18540 T18539 arg1Of evaluate,to
R9553 T18541 T18540 arg2Of how,evaluate
R9554 T18543 T18542 arg1Of production,IL-17
R9555 T18543 T18544 arg1Of production,is
R9556 T18543 T18545 arg2Of production,regulated
R9557 T18545 T18541 arg1Of regulated,how
R9558 T18545 T18544 arg2Of regulated,is
R9559 T18545 T18546 arg1Of regulated,in
R9560 T18548 T18546 arg2Of PBMC,in
R9561 T18548 T18547 arg1Of PBMC,RA
R9562 T18550 T18549 arg1Of and,","
R9563 T18553 T18551 arg1Of pathway,which
R9564 T18553 T18552 arg1Of pathway,signaling
R9565 T18553 T18555 arg2Of pathway,used
R9566 T18554 T18555 arg1Of it,used
R9567 T18555 T18550 arg2Of used,and
R9568 T18556 T18557 arg1Of Levels,of
R9569 T18556 T18559 arg1Of Levels,were
R9570 T18556 T18560 arg2Of Levels,found
R9571 T18556 T18562 arg1Of Levels,be
R9572 T18556 T18563 arg1Of Levels,higher
R9573 T18558 T18557 arg2Of IL-17,of
R9574 T18560 T18559 arg2Of found,were
R9575 T18562 T18560 arg3Of be,found
R9576 T18562 T18561 arg1Of be,to
R9577 T18563 T18562 arg2Of higher,be
R9578 T18563 T18564 arg1Of higher,in
R9579 T18563 T18568 arg1Of higher,than
R9580 T18567 T18564 arg2Of fluid,in
R9581 T18567 T18565 arg1Of fluid,RA
R9582 T18567 T18566 arg1Of fluid,synovial
R9583 T18569 T18568 arg2Of in,than
R9584 T18572 T18569 arg2Of fluid,in
R9585 T18572 T18570 arg1Of fluid,OA
R9586 T18572 T18571 arg1Of fluid,synovial
R9587 T18572 T18573 arg1Of fluid,[
R9588 T18574 T18573 arg2Of 15,[
R9589 T18575 T18573 arg3Of ],[
R9590 T18578 T18579 arg1Of there,are
R9591 T18579 T18576 arg1Of are,However
R9592 T18579 T18577 arg1Of are,","
R9593 T18581 T18579 arg2Of data,are
R9594 T18581 T18580 arg1Of data,few
R9595 T18581 T18582 arg1Of data,available
R9596 T18581 T18586 arg1Of data,that
R9597 T18581 T18587 arg1Of data,stimulate
R9598 T18582 T18583 arg1Of available,on
R9599 T18585 T18583 arg2Of agents,on
R9600 T18585 T18584 arg1Of agents,the
R9601 T18587 T18592 arg1Of stimulate,","
R9602 T18587 T18593 arg1Of stimulate,although
R9603 T18589 T18587 arg2Of production,stimulate
R9604 T18589 T18588 arg1Of production,IL-17
R9605 T18589 T18590 arg1Of production,in
R9606 T18591 T18590 arg2Of RA,in
R9607 T18596 T18594 arg1Of level,the
R9608 T18596 T18595 arg1Of level,highest
R9609 T18596 T18597 arg1Of level,of
R9610 T18596 T18600 arg1Of level,can
R9611 T18596 T18601 arg1Of level,be
R9612 T18596 T18602 arg2Of level,achieved
R9613 T18599 T18597 arg2Of production,of
R9614 T18599 T18598 arg1Of production,IL-17
R9615 T18602 T18593 arg2Of achieved,although
R9616 T18602 T18600 arg2Of achieved,can
R9617 T18602 T18601 arg2Of achieved,be
R9618 T18602 T18609 arg1Of achieved,[
R9619 T18605 T18602 arg1Of stimulation,achieved
R9620 T18605 T18603 arg2Of stimulation,by
R9621 T18605 T18604 arg1Of stimulation,anti-CD3/anti-CD28
R9622 T18605 T18606 arg1Of stimulation,in
R9623 T18608 T18606 arg2Of individuals,in
R9624 T18608 T18607 arg1Of individuals,healthy
R9625 T18610 T18609 arg2Of 25,[
R9626 T18611 T18609 arg3Of ],[
R9627 T18614 T18612 arg2Of experiments,In
R9628 T18614 T18613 arg1Of experiments,our
R9629 T18616 T18617 arg1Of PHA,as
R9630 T18616 T18632 arg1Of PHA,increased
R9631 T18618 T18622 arg1Of mitogens,as
R9632 T18622 T18617 arg2Of as,as
R9633 T18622 T18619 arg1Of as,","
R9634 T18622 T18620 arg1Of as,as
R9635 T18622 T18621 arg1Of as,well
R9636 T18622 T18624 arg1Of as,for
R9637 T18623 T18622 arg2Of anti-CD3/anti-CD28,as
R9638 T18625 T18624 arg2Of signaling,for
R9639 T18625 T18626 arg1Of signaling,through
R9640 T18630 T18626 arg2Of receptor,through
R9641 T18630 T18627 arg1Of receptor,the
R9642 T18630 T18628 arg1Of receptor,T
R9643 T18630 T18629 arg1Of receptor,cell
R9644 T18632 T18612 arg1Of increased,In
R9645 T18632 T18615 arg1Of increased,","
R9646 T18632 T18631 arg1Of increased,","
R9647 T18632 T18638 arg1Of increased,in
R9648 T18634 T18632 arg2Of production,increased
R9649 T18634 T18633 arg1Of production,IL-17
R9650 T18634 T18635 arg1Of production,from
R9651 T18637 T18635 arg2Of PBMC,from
R9652 T18637 T18636 arg1Of PBMC,RA
R9653 T18641 T18638 arg2Of manner,in
R9654 T18641 T18639 arg1Of manner,a
R9655 T18641 T18640 arg1Of manner,dose-dependent
R9656 T18642 T18643 arg1Of We,found
R9657 T18643 T18644 arg1Of found,","
R9658 T18643 T18645 arg1Of found,by
R9659 T18643 T18655 arg1Of found,","
R9660 T18649 T18645 arg2Of assay,by
R9661 T18649 T18646 arg1Of assay,a
R9662 T18649 T18647 arg1Of assay,cell
R9663 T18649 T18648 arg1Of assay,proliferation
R9664 T18649 T18650 arg1Of assay,(
R9665 T18651 T18650 arg2Of data,(
R9666 T18651 T18653 arg2Of data,shown
R9667 T18653 T18652 arg1Of shown,not
R9668 T18654 T18650 arg3Of ),(
R9669 T18658 T18657 arg1Of upregulation,this
R9670 T18658 T18659 arg1Of upregulation,of
R9671 T18658 T18661 arg1Of upregulation,might
R9672 T18658 T18662 arg1Of upregulation,be
R9673 T18658 T18664 arg1Of upregulation,to
R9674 T18658 T18670 arg1Of upregulation,to
R9675 T18660 T18659 arg2Of IL-17,of
R9676 T18662 T18643 arg2Of be,found
R9677 T18662 T18656 arg1Of be,that
R9678 T18662 T18661 arg2Of be,might
R9679 T18664 T18663 arg1Of to,due
R9680 T18664 T18669 arg1Of to,than
R9681 T18667 T18664 arg2Of activity,to
R9682 T18667 T18665 arg2Of activity,increased
R9683 T18667 T18666 arg1Of activity,cellular
R9684 T18669 T18662 arg2Of than,be
R9685 T18669 T18668 arg1Of than,rather
R9686 T18670 T18669 arg2Of to,than
R9687 T18672 T18670 arg2Of proliferation,to
R9688 T18672 T18671 arg1Of proliferation,cellular
R9689 T18673 T18674 arg1Of IL-17,is
R9690 T18673 T18675 arg2Of IL-17,produced
R9691 T18675 T18674 arg2Of produced,is
R9692 T18675 T18676 arg1Of produced,mainly
R9693 T18675 T18692 arg1Of produced,[
R9694 T18681 T18678 arg2Of cells,activated
R9695 T18681 T18679 arg1Of cells,CD4+
R9696 T18681 T18680 arg1Of cells,T
R9697 T18681 T18682 arg1Of cells,","
R9698 T18681 T18684 arg1Of cells,for
R9699 T18681 T18687 arg1Of cells,","
R9700 T18684 T18683 arg1Of for,especially
R9701 T18686 T18684 arg2Of cells,for
R9702 T18686 T18685 arg1Of cells,Th1/Th0
R9703 T18687 T18675 arg1Of ",",produced
R9704 T18687 T18677 arg2Of ",",by
R9705 T18691 T18687 arg2Of phenotype,","
R9706 T18691 T18688 arg1Of phenotype,not
R9707 T18691 T18689 arg1Of phenotype,the
R9708 T18691 T18690 arg1Of phenotype,Th2
R9709 T18693 T18692 arg2Of 26,[
R9710 T18694 T18692 arg3Of ],[
R9711 T18697 T18698 arg1Of it,can
R9712 T18697 T18700 arg1Of it,be
R9713 T18697 T18701 arg2Of it,produced
R9714 T18701 T18695 arg1Of produced,However
R9715 T18701 T18696 arg1Of produced,","
R9716 T18701 T18698 arg2Of produced,can
R9717 T18701 T18699 arg1Of produced,also
R9718 T18701 T18700 arg2Of produced,be
R9719 T18701 T18706 arg1Of produced,via
R9720 T18705 T18701 arg1Of cells,produced
R9721 T18705 T18702 arg2Of cells,by
R9722 T18705 T18703 arg1Of cells,CD8+
R9723 T18705 T18704 arg1Of cells,T
R9724 T18710 T18706 arg2Of mechanism,via
R9725 T18710 T18707 arg1Of mechanism,an
R9726 T18710 T18708 arg1Of mechanism,IL-23
R9727 T18710 T18709 arg1Of mechanism,triggering
R9728 T18710 T18711 arg1Of mechanism,in
R9729 T18714 T18711 arg2Of infection,in
R9730 T18714 T18712 arg1Of infection,Gram-negative
R9731 T18714 T18713 arg1Of infection,pulmonary
R9732 T18714 T18715 arg1Of infection,[
R9733 T18716 T18715 arg2Of 14,[
R9734 T18717 T18715 arg3Of ],[
R9735 T18719 T18718 arg2Of addition,In
R9736 T18722 T18721 arg1Of production,IL-17
R9737 T18722 T18723 arg1Of production,was
R9738 T18722 T18725 arg2Of production,augmented
R9739 T18725 T18718 arg1Of augmented,In
R9740 T18725 T18720 arg1Of augmented,","
R9741 T18725 T18723 arg2Of augmented,was
R9742 T18725 T18724 arg1Of augmented,significantly
R9743 T18728 T18725 arg1Of cells,augmented
R9744 T18728 T18726 arg2Of cells,by
R9745 T18728 T18727 arg1Of cells,T
R9746 T18728 T18729 arg1Of cells,recognizing
R9747 T18729 T18733 arg1Of recognizing,in
R9748 T18729 T18738 arg1Of recognizing,[
R9749 T18732 T18729 arg2Of collagen,recognizing
R9750 T18732 T18730 arg1Of collagen,type
R9751 T18732 T18731 arg1Of collagen,II
R9752 T18737 T18733 arg2Of model,in
R9753 T18737 T18734 arg1Of model,a
R9754 T18737 T18735 arg1Of model,collagen-induced
R9755 T18737 T18736 arg1Of model,arthritis
R9756 T18739 T18738 arg2Of 27,[
R9757 T18740 T18738 arg3Of ],[
R9758 T18743 T18741 arg1Of interaction,A
R9759 T18743 T18742 arg1Of interaction,complex
R9760 T18743 T18744 arg1Of interaction,between
R9761 T18743 T18750 arg1Of interaction,might
R9762 T18743 T18751 arg1Of interaction,produce
R9763 T18745 T18744 arg2Of cells,between
R9764 T18745 T18746 arg1Of cells,in
R9765 T18749 T18746 arg2Of joints,in
R9766 T18749 T18747 arg1Of joints,inflamed
R9767 T18749 T18748 arg1Of joints,RA
R9768 T18751 T18750 arg2Of produce,might
R9769 T18753 T18751 arg2Of variety,produce
R9770 T18753 T18752 arg1Of variety,a
R9771 T18753 T18754 arg1Of variety,of
R9772 T18756 T18757 arg1Of cytokines,and
R9773 T18757 T18754 arg2Of and,of
R9774 T18757 T18755 arg1Of and,proinflammatory
R9775 T18757 T18759 arg1Of and,","
R9776 T18757 T18760 arg1Of and,which
R9777 T18757 T18762 arg1Of and,activate
R9778 T18758 T18757 arg2Of chemokines,and
R9779 T18762 T18761 arg1Of activate,also
R9780 T18762 T18765 arg1Of activate,in
R9781 T18764 T18762 arg2Of cells,activate
R9782 T18764 T18763 arg1Of cells,other
R9783 T18767 T18765 arg2Of joints,in
R9784 T18767 T18766 arg1Of joints,the
R9785 T18769 T18768 arg2Of example,For
R9786 T18771 T18772 arg1Of IL-17,stimulates
R9787 T18772 T18768 arg1Of stimulates,For
R9788 T18772 T18770 arg1Of stimulates,","
R9789 T18774 T18772 arg2Of synoviocytes,stimulates
R9790 T18774 T18773 arg1Of synoviocytes,rheumatoid
R9791 T18774 T18776 arg1Of synoviocytes,secrete
R9792 T18776 T18772 arg3Of secrete,stimulates
R9793 T18776 T18775 arg1Of secrete,to
R9794 T18778 T18776 arg2Of cytokines,secrete
R9795 T18778 T18777 arg1Of cytokines,several
R9796 T18778 T18780 arg1Of cytokines,as
R9797 T18780 T18779 arg1Of as,such
R9798 T18781 T18782 arg1Of IL-6,","
R9799 T18782 T18784 arg1Of ",",and
R9800 T18783 T18782 arg2Of IL-8,","
R9801 T18784 T18792 arg1Of and,as
R9802 T18788 T18784 arg2Of gene,and
R9803 T18788 T18785 arg1Of gene,tumor
R9804 T18788 T18786 arg1Of gene,necrosis
R9805 T18788 T18787 arg1Of gene,factor-stimulated
R9806 T18788 T18789 arg1Of gene,6
R9807 T18792 T18780 arg2Of as,as
R9808 T18792 T18790 arg1Of as,as
R9809 T18792 T18791 arg1Of as,well
R9810 T18794 T18792 arg2Of E2,as
R9811 T18794 T18793 arg1Of E2,prostaglandin
R9812 T18794 T18796 arg1Of E2,vitro
R9813 T18794 T18797 arg1Of E2,[
R9814 T18796 T18795 arg1Of vitro,in
R9815 T18798 T18797 arg2Of "12,28,29",[
R9816 T18799 T18797 arg3Of ],[
R9817 T18800 T18801 arg1Of There,are
R9818 T18804 T18802 arg1Of few,as
R9819 T18804 T18803 arg1Of few,yet
R9820 T18805 T18801 arg2Of data,are
R9821 T18805 T18804 arg1Of data,few
R9822 T18805 T18806 arg1Of data,available
R9823 T18806 T18807 arg1Of available,on
R9824 T18809 T18807 arg2Of agents,on
R9825 T18809 T18808 arg1Of agents,the
R9826 T18809 T18810 arg1Of agents,that
R9827 T18809 T18811 arg1Of agents,stimulate
R9828 T18811 T18816 arg1Of stimulate,","
R9829 T18811 T18817 arg1Of stimulate,although
R9830 T18813 T18811 arg2Of production,stimulate
R9831 T18813 T18812 arg1Of production,IL-17
R9832 T18813 T18814 arg1Of production,in
R9833 T18815 T18814 arg2Of RA,in
R9834 T18819 T18818 arg1Of cytokines,some
R9835 T18819 T18820 arg1Of cytokines,(
R9836 T18819 T18825 arg1Of cytokines,have
R9837 T18819 T18826 arg1Of cytokines,been
R9838 T18819 T18827 arg2Of cytokines,known
R9839 T18819 T18829 arg1Of cytokines,regulate
R9840 T18821 T18822 arg1Of IL-15,and
R9841 T18822 T18820 arg2Of and,(
R9842 T18823 T18822 arg2Of IL-23,and
R9843 T18824 T18820 arg3Of ),(
R9844 T18827 T18817 arg2Of known,although
R9845 T18827 T18825 arg2Of known,have
R9846 T18827 T18826 arg2Of known,been
R9847 T18829 T18827 arg3Of regulate,known
R9848 T18829 T18828 arg1Of regulate,to
R9849 T18829 T18832 arg1Of regulate,[
R9850 T18831 T18829 arg2Of production,regulate
R9851 T18831 T18830 arg1Of production,IL-17
R9852 T18833 T18832 arg2Of "13,14",[
R9853 T18834 T18832 arg3Of ],[
R9854 T18835 T18837 arg1Of We,investigated
R9855 T18837 T18836 arg1Of investigated,therefore
R9856 T18837 T18865 modOf investigated,using
R9857 T18840 T18839 arg1Of vitro,in
R9858 T18841 T18840 arg1Of production,vitro
R9859 T18841 T18842 arg1Of production,of
R9860 T18841 T18844 arg1Of production,in
R9861 T18841 T18857 arg1Of production,as
R9862 T18843 T18842 arg2Of IL-17,of
R9863 T18846 T18844 arg2Of PBMC,in
R9864 T18846 T18845 arg1Of PBMC,RA
R9865 T18846 T18847 arg1Of PBMC,responding
R9866 T18847 T18848 arg1Of responding,to
R9867 T18850 T18848 arg2Of variety,to
R9868 T18850 T18849 arg1Of variety,a
R9869 T18850 T18851 arg1Of variety,of
R9870 T18852 T18853 arg1Of cytokines/chemokines,and
R9871 T18853 T18851 arg2Of and,of
R9872 T18854 T18853 arg2Of mitogens,and
R9873 T18857 T18837 arg2Of as,investigated
R9874 T18857 T18838 arg1Of as,the
R9875 T18857 T18855 arg1Of as,as
R9876 T18857 T18856 arg1Of as,well
R9877 T18860 T18858 arg1Of receptor,T
R9878 T18860 T18859 arg1Of receptor,cell
R9879 T18860 T18861 arg1Of receptor,(
R9880 T18862 T18861 arg2Of TCR,(
R9881 T18863 T18861 arg3Of ),(
R9882 T18864 T18857 arg2Of ligation,as
R9883 T18864 T18860 arg1Of ligation,receptor
R9884 T18866 T18865 arg2Of anti-CD3/anti-CD28,using
R9885 T18868 T18867 arg1Of studies,Our
R9886 T18868 T18869 arg1Of studies,demonstrated
R9887 T18871 T18872 arg1Of IL-15,and
R9888 T18872 T18876 arg1Of and,as
R9889 T18873 T18872 arg2Of MCP-1,and
R9890 T18876 T18874 arg1Of as,as
R9891 T18876 T18875 arg1Of as,well
R9892 T18876 T18880 arg1Of as,increased
R9893 T18878 T18876 arg2Of ligation,as
R9894 T18878 T18877 arg1Of ligation,TCR
R9895 T18880 T18869 arg2Of increased,demonstrated
R9896 T18880 T18870 arg1Of increased,that
R9897 T18880 T18879 arg1Of increased,significantly
R9898 T18882 T18880 arg2Of production,increased
R9899 T18882 T18881 arg1Of production,the
R9900 T18882 T18883 arg1Of production,of
R9901 T18882 T18885 arg1Of production,in
R9902 T18884 T18883 arg2Of IL-17,of
R9903 T18887 T18885 arg2Of PBMC,in
R9904 T18887 T18886 arg1Of PBMC,RA
R9905 T18889 T18890 arg1Of IL-15,or
R9906 T18890 T18888 arg1Of or,Adding
R9907 T18890 T18892 arg1Of or,to
R9908 T18890 T18895 arg1Of or,augmented
R9909 T18891 T18890 arg2Of MCP-1,or
R9910 T18894 T18892 arg2Of ligation,to
R9911 T18894 T18893 arg1Of ligation,TCR
R9912 T18895 T18899 arg1Of augmented,markedly
R9913 T18897 T18895 arg2Of production,augmented
R9914 T18897 T18896 arg1Of production,IL-17
R9915 T18899 T18898 arg1Of markedly,more
R9916 T18901 T18900 arg2Of contrast,In
R9917 T18903 T18904 arg1Of IL-1,and
R9918 T18904 T18906 arg1Of and,","
R9919 T18904 T18907 arg1Of and,which
R9920 T18904 T18908 arg1Of and,are
R9921 T18904 T18909 arg2Of and,known
R9922 T18904 T18911 arg1Of and,have
R9923 T18904 T18916 arg1Of and,be
R9924 T18904 T18917 arg2Of and,increased
R9925 T18904 T18922 arg1Of and,did
R9926 T18904 T18924 arg1Of and,affect
R9927 T18905 T18904 arg2Of TNF-α,and
R9928 T18909 T18908 arg2Of known,are
R9929 T18911 T18910 arg1Of have,to
R9930 T18911 T18914 arg1Of have,and
R9931 T18913 T18911 arg2Of properties,have
R9932 T18913 T18912 arg1Of properties,proinflammatory
R9933 T18914 T18909 arg3Of and,known
R9934 T18917 T18914 arg2Of increased,and
R9935 T18917 T18915 arg1Of increased,to
R9936 T18917 T18916 arg2Of increased,be
R9937 T18917 T18918 arg1Of increased,in
R9938 T18920 T18918 arg2Of joints,in
R9939 T18920 T18919 arg1Of joints,RA
R9940 T18924 T18900 arg1Of affect,In
R9941 T18924 T18902 arg1Of affect,","
R9942 T18924 T18921 arg1Of affect,","
R9943 T18924 T18922 arg2Of affect,did
R9944 T18924 T18923 arg1Of affect,not
R9945 T18926 T18924 arg2Of production,affect
R9946 T18926 T18925 arg1Of production,IL-17
R9947 T18928 T18927 arg1Of data,Our
R9948 T18928 T18929 arg1Of data,were
R9949 T18928 T18930 arg1Of data,consistent
R9950 T18930 T18929 arg2Of consistent,were
R9951 T18930 T18931 arg1Of consistent,with
R9952 T18934 T18931 arg2Of report,with
R9953 T18934 T18932 arg1Of report,a
R9954 T18934 T18933 arg1Of report,recent
R9955 T18936 T18937 arg1Of IL-15,triggered
R9956 T18937 T18945 arg1Of triggered,but
R9957 T18939 T18938 arg1Of vitro,in
R9958 T18941 T18937 arg2Of production,triggered
R9959 T18941 T18939 arg1Of production,vitro
R9960 T18941 T18940 arg1Of production,IL-17
R9961 T18941 T18942 arg1Of production,in
R9962 T18943 T18942 arg2Of PBMC,in
R9963 T18945 T18934 arg2Of but,report
R9964 T18945 T18935 arg1Of but,that
R9965 T18945 T18944 arg1Of but,","
R9966 T18946 T18947 arg1Of TNF-α,did
R9967 T18946 T18949 arg1Of TNF-α,do
R9968 T18946 T18950 arg1Of TNF-α,so
R9969 T18949 T18945 arg2Of do,but
R9970 T18949 T18947 arg2Of do,did
R9971 T18949 T18948 arg1Of do,not
R9972 T18949 T18951 arg1Of do,[
R9973 T18950 T18949 arg2Of so,do
R9974 T18952 T18951 arg2Of 13,[
R9975 T18953 T18951 arg3Of ],[
R9976 T18955 T18956 arg1Of there,were
R9977 T18956 T18954 arg2Of were,Although
R9978 T18958 T18956 arg2Of data,were
R9979 T18958 T18957 arg1Of data,no
R9980 T18958 T18959 arg1Of data,that
R9981 T18960 T18962 arg1Of MCP-1,induces
R9982 T18962 T18959 arg2Of induces,that
R9983 T18962 T18961 arg1Of induces,directly
R9984 T18965 T18962 arg2Of activation,induces
R9985 T18965 T18963 arg1Of activation,T
R9986 T18965 T18964 arg1Of activation,cell
R9987 T18967 T18968 arg1Of it,might
R9988 T18967 T18969 arg1Of it,exert
R9989 T18969 T18954 arg1Of exert,Although
R9990 T18969 T18966 arg1Of exert,","
R9991 T18969 T18968 arg2Of exert,might
R9992 T18969 T18971 arg1Of exert,indirectly
R9993 T18969 T18972 arg1Of exert,on
R9994 T18969 T18975 arg1Of exert,through
R9995 T18970 T18969 arg2Of effects,exert
R9996 T18974 T18972 arg2Of cells,on
R9997 T18974 T18973 arg1Of cells,T
R9998 T18977 T18975 arg2Of activation,through
R9999 T18977 T18976 arg1Of activation,the
R10000 T18977 T18978 arg1Of activation,of
R10001 T18977 T18980 arg1Of activation,in
R10002 T18979 T18978 arg2Of monocytes/macrophages,of
R10003 T18982 T18980 arg2Of cultures,in
R10004 T18982 T18981 arg1Of cultures,PBMC
R10005 T18984 T18983 arg2Of reported,As
R10006 T18984 T18985 arg1Of reported,for
R10007 T18987 T18985 arg2Of individuals,for
R10008 T18987 T18986 arg1Of individuals,normal
R10009 T18987 T18988 arg1Of individuals,[
R10010 T18989 T18988 arg2Of 25,[
R10011 T18990 T18988 arg3Of ],[
R10012 T18994 T18992 arg1Of activation,T
R10013 T18994 T18993 arg1Of activation,cell
R10014 T18994 T18995 arg1Of activation,through
R10015 T18994 T18998 arg1Of activation,increases
R10016 T18996 T18995 arg2Of anti-CD3/anti-CD28,through
R10017 T18998 T18983 arg1Of increases,As
R10018 T18998 T18991 arg1Of increases,","
R10019 T18998 T18997 arg1Of increases,also
R10020 T19000 T18998 arg2Of induction,increases
R10021 T19000 T18999 arg1Of induction,IL-17
R10022 T19000 T19001 arg1Of induction,in
R10023 T19003 T19001 arg2Of PBMC,in
R10024 T19003 T19002 arg1Of PBMC,RA
R10025 T19007 T19005 arg1Of pathway,the
R10026 T19007 T19006 arg1Of pathway,signaling
R10027 T19007 T19008 arg1Of pathway,for
R10028 T19007 T19015 arg1Of pathway,has
R10029 T19007 T19016 arg1Of pathway,been
R10030 T19007 T19017 arg2Of pathway,documented
R10031 T19010 T19008 arg2Of induction,for
R10032 T19010 T19009 arg1Of induction,the
R10033 T19010 T19011 arg1Of induction,of
R10034 T19010 T19013 arg1Of induction,by
R10035 T19012 T19011 arg2Of cytokines/chemokines,of
R10036 T19014 T19013 arg2Of IL-17,by
R10037 T19017 T19004 arg2Of documented,Although
R10038 T19017 T19015 arg2Of documented,has
R10039 T19017 T19016 arg2Of documented,been
R10040 T19017 T19018 arg1Of documented,widely
R10041 T19017 T19019 arg1Of documented,[
R10042 T19020 T19019 arg2Of "8,30,31",[
R10043 T19021 T19019 arg3Of ],[
R10044 T19024 T19023 arg1Of data,no
R10045 T19024 T19025 arg1Of data,have
R10046 T19024 T19026 arg1Of data,been
R10047 T19024 T19027 arg1Of data,available
R10048 T19026 T19004 arg1Of been,Although
R10049 T19026 T19022 arg1Of been,","
R10050 T19026 T19025 arg2Of been,have
R10051 T19027 T19026 arg2Of available,been
R10052 T19027 T19028 arg1Of available,on
R10053 T19029 T19028 arg2Of how,on
R10054 T19031 T19030 arg1Of production,IL-17
R10055 T19031 T19032 arg1Of production,can
R10056 T19031 T19033 arg1Of production,be
R10057 T19031 T19034 arg2Of production,regulated
R10058 T19034 T19029 arg1Of regulated,how
R10059 T19034 T19032 arg2Of regulated,can
R10060 T19034 T19033 arg2Of regulated,be
R10061 T19038 T19034 arg1Of pathways,regulated
R10062 T19038 T19035 arg2Of pathways,by
R10063 T19038 T19036 arg1Of pathways,certain
R10064 T19038 T19037 arg1Of pathways,signaling
R10065 T19040 T19039 arg2Of using,By
R10066 T19043 T19040 arg2Of inhibitors,using
R10067 T19043 T19041 arg1Of inhibitors,signal
R10068 T19043 T19042 arg1Of inhibitors,transduction
R10069 T19045 T19040 arg1Of we,using
R10070 T19045 T19047 arg1Of we,examined
R10071 T19047 T19039 arg1Of examined,By
R10072 T19047 T19044 arg1Of examined,","
R10073 T19047 T19046 arg1Of examined,therefore
R10074 T19048 T19047 arg2Of which,examined
R10075 T19050 T19048 arg1Of pathway,which
R10076 T19050 T19049 arg1Of pathway,signaling
R10077 T19050 T19051 arg1Of pathway,was
R10078 T19050 T19053 arg2Of pathway,involved
R10079 T19053 T19051 arg2Of involved,was
R10080 T19053 T19052 arg1Of involved,mainly
R10081 T19053 T19054 arg1Of involved,in
R10082 T19056 T19054 arg2Of induction,in
R10083 T19056 T19055 arg1Of induction,the
R10084 T19056 T19057 arg1Of induction,of
R10085 T19056 T19059 arg1Of induction,in
R10086 T19058 T19057 arg2Of IL-17,of
R10087 T19061 T19059 arg2Of PBMC,in
R10088 T19061 T19060 arg1Of PBMC,RA
R10089 T19062 T19063 arg1Of We,identified
R10090 T19067 T19065 arg1Of production,anti-CD3-induced
R10091 T19067 T19066 arg1Of production,IL-17
R10092 T19067 T19068 arg1Of production,in
R10093 T19067 T19071 arg1Of production,was
R10094 T19067 T19073 arg2Of production,hampered
R10095 T19070 T19068 arg2Of PBMC,in
R10096 T19070 T19069 arg1Of PBMC,RA
R10097 T19073 T19063 arg2Of hampered,identified
R10098 T19073 T19064 arg1Of hampered,that
R10099 T19073 T19071 arg2Of hampered,was
R10100 T19073 T19072 arg1Of hampered,significantly
R10101 T19077 T19075 arg1Of inhibitor,the
R10102 T19077 T19076 arg1Of inhibitor,PI3K
R10103 T19078 T19077 arg1Of LY294002,inhibitor
R10104 T19078 T19079 arg1Of LY294002,and
R10105 T19079 T19073 arg1Of and,hampered
R10106 T19079 T19074 arg2Of and,by
R10107 T19079 T19084 arg1Of and,to
R10108 T19082 T19080 arg1Of inhibitor,the
R10109 T19082 T19081 arg1Of inhibitor,NF-κB
R10110 T19083 T19079 arg2Of PDTC,and
R10111 T19083 T19082 arg1Of PDTC,inhibitor
R10112 T19086 T19084 arg2Of levels,to
R10113 T19086 T19085 arg1Of levels,comparable
R10114 T19086 T19087 arg1Of levels,of
R10115 T19089 T19087 arg2Of production,of
R10116 T19089 T19088 arg1Of production,basal
R10117 T19089 T19090 arg1Of production,without
R10118 T19091 T19090 arg2Of stimulation,without
R10119 T19092 T19094 arg1Of We,found
R10120 T19094 T19093 arg1Of found,also
R10121 T19098 T19096 arg1Of production,anti-CD3-induced
R10122 T19098 T19097 arg1Of production,IL-17
R10123 T19098 T19099 arg1Of production,was
R10124 T19098 T19100 arg2Of production,downregulated
R10125 T19100 T19094 arg2Of downregulated,found
R10126 T19100 T19095 arg1Of downregulated,that
R10127 T19100 T19099 arg2Of downregulated,was
R10128 T19103 T19100 arg1Of addition,downregulated
R10129 T19103 T19101 arg2Of addition,by
R10130 T19103 T19102 arg1Of addition,the
R10131 T19103 T19104 arg1Of addition,of
R10132 T19105 T19104 arg2Of SB203580,of
R10133 T19105 T19106 arg1Of SB203580,","
R10134 T19110 T19106 arg2Of inhibitor,","
R10135 T19110 T19107 arg1Of inhibitor,a
R10136 T19110 T19108 arg1Of inhibitor,p38
R10137 T19110 T19109 arg1Of inhibitor,MAPK
R10138 T19113 T19112 arg2Of interesting,is
R10139 T19116 T19115 arg1Of series,a
R10140 T19116 T19117 arg1Of series,of
R10141 T19116 T19119 arg1Of series,supports
R10142 T19118 T19117 arg2Of evidence,of
R10143 T19119 T19111 arg1Of supports,It
R10144 T19119 T19112 arg1Of supports,is
R10145 T19119 T19113 arg1Of supports,interesting
R10146 T19119 T19114 arg1Of supports,that
R10147 T19120 T19119 arg2Of crosstalk,supports
R10148 T19120 T19121 arg1Of crosstalk,between
R10149 T19122 T19123 arg1Of NF-κB,and
R10150 T19123 T19121 arg2Of and,between
R10151 T19124 T19123 arg2Of p38,and
R10152 T19126 T19125 arg2Of myocytes,In
R10153 T19129 T19128 arg1Of kinase-β,IκB
R10154 T19129 T19130 arg1Of kinase-β,is
R10155 T19129 T19131 arg2Of kinase-β,activated
R10156 T19131 T19130 arg2Of activated,is
R10157 T19131 T19134 arg1Of activated,[
R10158 T19131 T19138 arg1Of activated,and
R10159 T19133 T19131 arg1Of p38,activated
R10160 T19133 T19132 arg2Of p38,by
R10161 T19135 T19134 arg2Of 32,[
R10162 T19136 T19134 arg3Of ],[
R10163 T19138 T19125 arg1Of and,In
R10164 T19138 T19127 arg1Of and,","
R10165 T19138 T19137 arg1Of and,","
R10166 T19141 T19139 arg1Of p38,the
R10167 T19141 T19140 arg2Of p38,activated
R10168 T19141 T19142 arg1Of p38,can
R10169 T19141 T19143 arg1Of p38,stimulate
R10170 T19143 T19138 arg2Of stimulate,and
R10171 T19143 T19142 arg2Of stimulate,can
R10172 T19143 T19145 arg1Of stimulate,by
R10173 T19144 T19143 arg2Of NF-κB,stimulate
R10174 T19147 T19145 arg2Of mechanism,by
R10175 T19147 T19146 arg1Of mechanism,a
R10176 T19147 T19148 arg1Of mechanism,involving
R10177 T19152 T19148 arg2Of protein,involving
R10178 T19152 T19149 arg1Of protein,histone
R10179 T19152 T19150 arg1Of protein,acetylase
R10180 T19152 T19151 arg1Of protein,p300/CREB-binding
R10181 T19152 T19153 arg1Of protein,[
R10182 T19154 T19153 arg2Of 33,[
R10183 T19155 T19153 arg3Of ],[
R10184 T19157 T19156 arg1Of results,Our
R10185 T19157 T19158 arg1Of results,revealed
R10186 T19162 T19160 arg1Of activation,p38
R10187 T19162 T19161 arg1Of activation,MAPK
R10188 T19162 T19163 arg1Of activation,was
R10189 T19162 T19165 arg2Of activation,affected
R10190 T19165 T19158 arg2Of affected,revealed
R10191 T19165 T19159 arg1Of affected,that
R10192 T19165 T19163 arg2Of affected,was
R10193 T19165 T19164 arg1Of affected,not
R10194 T19165 T19168 arg1Of affected,","
R10195 T19165 T19169 arg1Of affected,whereas
R10196 T19165 T19177 arg1Of affected,","
R10197 T19165 T19178 arg1Of affected,which
R10198 T19165 T19179 arg1Of affected,provided
R10199 T19167 T19165 arg1Of LY294002,affected
R10200 T19167 T19166 arg2Of LY294002,by
R10201 T19172 T19170 arg1Of activity,NF-κB
R10202 T19172 T19171 arg1Of activity,binding
R10203 T19172 T19173 arg1Of activity,was
R10204 T19172 T19174 arg2Of activity,decreased
R10205 T19174 T19169 arg2Of decreased,whereas
R10206 T19174 T19173 arg2Of decreased,was
R10207 T19176 T19174 arg1Of LY294002,decreased
R10208 T19176 T19175 arg2Of LY294002,by
R10209 T19181 T19179 arg2Of evidence,provided
R10210 T19181 T19180 arg1Of evidence,the
R10211 T19181 T19182 arg1Of evidence,for
R10212 T19186 T19182 arg2Of pathway,for
R10213 T19186 T19183 arg1Of pathway,a
R10214 T19186 T19184 arg1Of pathway,p38
R10215 T19186 T19185 arg1Of pathway,MAPK
R10216 T19186 T19187 arg1Of pathway,independent
R10217 T19187 T19188 arg1Of independent,of
R10218 T19190 T19188 arg2Of activation,of
R10219 T19190 T19189 arg1Of activation,PI3K
R10220 T19193 T19191 arg1Of relationship,The
R10221 T19193 T19192 arg1Of relationship,direct
R10222 T19193 T19194 arg1Of relationship,between
R10223 T19193 T19201 arg1Of relationship,needs
R10224 T19193 T19203 arg1Of relationship,be
R10225 T19193 T19204 arg2Of relationship,studied
R10226 T19195 T19196 arg1Of p38,and
R10227 T19196 T19194 arg2Of and,between
R10228 T19196 T19198 arg1Of and,for
R10229 T19197 T19196 arg2Of NF-κB,and
R10230 T19200 T19198 arg2Of production,for
R10231 T19200 T19199 arg1Of production,IL-17
R10232 T19204 T19201 arg2Of studied,needs
R10233 T19204 T19202 arg1Of studied,to
R10234 T19204 T19203 arg2Of studied,be
R10235 T19204 T19205 arg1Of studied,in
R10236 T19207 T19205 arg2Of experiments,in
R10237 T19207 T19206 arg1Of experiments,future
R10238 T19209 T19208 arg1Of search,The
R10239 T19209 T19210 arg1Of search,for
R10240 T19209 T19216 arg1Of search,seemed
R10241 T19209 T19218 arg1Of search,have
R10242 T19213 T19210 arg2Of pathway,for
R10243 T19213 T19211 arg1Of pathway,a
R10244 T19213 T19212 arg1Of pathway,downstream
R10245 T19213 T19214 arg1Of pathway,of
R10246 T19215 T19214 arg2Of PI3K,of
R10247 T19218 T19216 arg2Of have,seemed
R10248 T19218 T19217 arg1Of have,to
R10249 T19218 T19234 arg1Of have,at
R10250 T19221 T19219 arg1Of response,a
R10251 T19221 T19220 arg1Of response,maximal
R10252 T19221 T19222 arg1Of response,of
R10253 T19221 T19225 arg1Of response,at
R10254 T19221 T19228 arg1Of response,and
R10255 T19224 T19222 arg2Of activation,of
R10256 T19224 T19223 arg1Of activation,Akt
R10257 T19227 T19225 arg2Of hour,at
R10258 T19227 T19226 arg1Of hour,1
R10259 T19228 T19218 arg2Of and,have
R10260 T19231 T19228 arg2Of loss,and
R10261 T19231 T19229 arg1Of loss,a
R10262 T19231 T19230 arg1Of loss,gradual
R10263 T19231 T19232 arg1Of loss,of
R10264 T19233 T19232 arg2Of activity,of
R10265 T19236 T19234 arg2Of hours,at
R10266 T19236 T19235 arg1Of hours,2
R10267 T19238 T19237 arg1Of fact,The
R10268 T19238 T19246 arg1Of fact,suggests
R10269 T19240 T19241 arg1Of Akt,is
R10270 T19240 T19242 arg2Of Akt,phosphorylated
R10271 T19242 T19238 arg2Of phosphorylated,fact
R10272 T19242 T19239 arg1Of phosphorylated,that
R10273 T19242 T19241 arg2Of phosphorylated,is
R10274 T19242 T19243 arg1Of phosphorylated,upon
R10275 T19245 T19243 arg2Of stimulation,upon
R10276 T19245 T19244 arg1Of stimulation,anti-CD3
R10277 T19249 T19246 arg2Of involvement,suggests
R10278 T19249 T19247 arg1Of involvement,the
R10279 T19249 T19248 arg1Of involvement,possible
R10280 T19249 T19250 arg1Of involvement,of
R10281 T19249 T19252 arg1Of involvement,in
R10282 T19251 T19250 arg2Of PI3K,of
R10283 T19254 T19252 arg2Of induction,in
R10284 T19254 T19253 arg1Of induction,the
R10285 T19254 T19255 arg1Of induction,of
R10286 T19254 T19257 arg1Of induction,in
R10287 T19256 T19255 arg2Of IL-17,of
R10288 T19258 T19257 arg2Of RA,in
R10289 T19260 T19259 arg2Of view,In
R10290 T19260 T19261 arg1Of view,of
R10291 T19263 T19261 arg2Of fact,of
R10292 T19263 T19262 arg1Of fact,the
R10293 T19265 T19266 arg1Of NF-κB,was
R10294 T19265 T19268 arg2Of NF-κB,activated
R10295 T19268 T19263 arg2Of activated,fact
R10296 T19268 T19264 arg1Of activated,that
R10297 T19268 T19266 arg2Of activated,was
R10298 T19268 T19267 arg1Of activated,also
R10299 T19272 T19273 arg1Of IL-15,or
R10300 T19273 T19268 arg1Of or,activated
R10301 T19273 T19269 arg2Of or,by
R10302 T19273 T19270 arg1Of or,anti-CD3/anti-CD28
R10303 T19273 T19271 arg1Of or,","
R10304 T19273 T19275 arg1Of or,in
R10305 T19274 T19273 arg2Of mitogens,or
R10306 T19277 T19275 arg2Of experiments,in
R10307 T19277 T19276 arg1Of experiments,our
R10308 T19280 T19259 arg1Of is,In
R10309 T19280 T19278 arg1Of is,","
R10310 T19282 T19280 arg2Of likely,is
R10311 T19282 T19281 arg1Of likely,most
R10312 T19286 T19284 arg1Of pathway,the
R10313 T19286 T19285 arg1Of pathway,NF-κB
R10314 T19286 T19287 arg1Of pathway,is
R10315 T19286 T19290 arg2Of pathway,involved
R10316 T19290 T19279 arg1Of involved,it
R10317 T19290 T19280 arg1Of involved,is
R10318 T19290 T19282 arg1Of involved,likely
R10319 T19290 T19283 arg1Of involved,that
R10320 T19290 T19287 arg2Of involved,is
R10321 T19290 T19288 arg1Of involved,also
R10322 T19290 T19289 arg1Of involved,actively
R10323 T19290 T19291 arg1Of involved,in
R10324 T19293 T19291 arg2Of induction,in
R10325 T19293 T19292 arg1Of induction,the
R10326 T19293 T19294 arg1Of induction,of
R10327 T19293 T19296 arg1Of induction,in
R10328 T19295 T19294 arg2Of IL-17,of
R10329 T19298 T19296 arg2Of PBMC,in
R10330 T19298 T19297 arg1Of PBMC,RA
R10331 T19300 T19299 arg2Of contrast,In
R10332 T19306 T19302 arg1Of pathway,the
R10333 T19306 T19303 arg1Of pathway,AP-1
R10334 T19306 T19304 arg1Of pathway,signal
R10335 T19306 T19305 arg1Of pathway,transduction
R10336 T19306 T19307 arg1Of pathway,","
R10337 T19306 T19315 arg1Of pathway,was
R10338 T19306 T19317 arg2Of pathway,activated
R10339 T19311 T19307 arg2Of pathway,","
R10340 T19311 T19308 arg1Of pathway,another
R10341 T19311 T19309 arg1Of pathway,important
R10342 T19311 T19310 arg1Of pathway,signaling
R10343 T19311 T19312 arg1Of pathway,for
R10344 T19313 T19312 arg2Of cytokines/chemokines,for
R10345 T19317 T19299 arg1Of activated,In
R10346 T19317 T19301 arg1Of activated,","
R10347 T19317 T19314 arg1Of activated,","
R10348 T19317 T19315 arg2Of activated,was
R10349 T19317 T19316 arg1Of activated,not
R10350 T19317 T19318 arg1Of activated,in
R10351 T19320 T19318 arg2Of experiments,in
R10352 T19320 T19319 arg1Of experiments,our
R10353 T19320 T19321 arg1Of experiments,(
R10354 T19322 T19321 arg2Of data,(
R10355 T19322 T19324 arg2Of data,shown
R10356 T19324 T19323 arg1Of shown,not
R10357 T19325 T19321 arg3Of ),(
R10358 T19327 T19328 arg1Of PI3K,and
R10359 T19328 T19337 arg1Of and,have
R10360 T19328 T19338 arg1Of and,been
R10361 T19328 T19339 arg2Of and,reported
R10362 T19328 T19341 arg1Of and,deliver
R10363 T19332 T19328 arg2Of Akt,and
R10364 T19332 T19329 arg1Of Akt,its
R10365 T19332 T19330 arg1Of Akt,downstream
R10366 T19332 T19331 arg1Of Akt,kinase
R10367 T19332 T19333 arg1Of Akt,in
R10368 T19334 T19333 arg2Of association,in
R10369 T19334 T19335 arg1Of association,with
R10370 T19336 T19335 arg2Of NF-κB,with
R10371 T19339 T19326 arg2Of reported,Although
R10372 T19339 T19337 arg2Of reported,have
R10373 T19339 T19338 arg2Of reported,been
R10374 T19341 T19339 arg3Of deliver,reported
R10375 T19341 T19340 arg1Of deliver,to
R10376 T19341 T19344 arg1Of deliver,in
R10377 T19343 T19341 arg2Of signals,deliver
R10378 T19343 T19342 arg1Of signals,activating
R10379 T19347 T19344 arg2Of types,in
R10380 T19347 T19345 arg1Of types,many
R10381 T19347 T19346 arg1Of types,cell
R10382 T19350 T19349 arg1Of data,the
R10383 T19350 T19351 arg1Of data,on
R10384 T19350 T19356 arg1Of data,are
R10385 T19350 T19357 arg1Of data,lacking
R10386 T19353 T19351 arg2Of signal,on
R10387 T19353 T19352 arg1Of signal,the
R10388 T19353 T19354 arg1Of signal,inducing
R10389 T19355 T19354 arg2Of IL-17,inducing
R10390 T19357 T19326 arg1Of lacking,Although
R10391 T19357 T19348 arg1Of lacking,","
R10392 T19357 T19356 arg2Of lacking,are
R10393 T19359 T19358 arg1Of data,Our
R10394 T19359 T19361 arg1Of data,demonstrated
R10395 T19361 T19360 arg1Of demonstrated,clearly
R10396 T19363 T19364 arg1Of PI3K/Akt,and
R10397 T19364 T19368 arg1Of and,could
R10398 T19364 T19369 arg1Of and,be
R10399 T19367 T19364 arg2Of activation,and
R10400 T19367 T19365 arg1Of activation,resultant
R10401 T19367 T19366 arg1Of activation,NF-κB
R10402 T19369 T19361 arg2Of be,demonstrated
R10403 T19369 T19362 arg1Of be,that
R10404 T19369 T19368 arg2Of be,could
R10405 T19372 T19369 arg2Of arbitrator,be
R10406 T19372 T19370 arg1Of arbitrator,an
R10407 T19372 T19371 arg1Of arbitrator,important
R10408 T19372 T19373 arg1Of arbitrator,of
R10409 T19372 T19380 arg1Of arbitrator,","
R10410 T19372 T19381 arg1Of arbitrator,on
R10411 T19375 T19373 arg2Of upregulation,of
R10412 T19375 T19374 arg1Of upregulation,the
R10413 T19375 T19376 arg1Of upregulation,of
R10414 T19375 T19378 arg1Of upregulation,in
R10415 T19377 T19376 arg2Of IL-17,of
R10416 T19379 T19378 arg2Of RA,in
R10417 T19383 T19381 arg2Of basis,on
R10418 T19383 T19382 arg1Of basis,the
R10419 T19383 T19384 arg1Of basis,of
R10420 T19383 T19387 arg1Of basis,showing
R10421 T19386 T19384 arg2Of experiments,of
R10422 T19386 T19385 arg1Of experiments,our
R10423 T19389 T19387 arg2Of blocking,showing
R10424 T19389 T19388 arg1Of blocking,simultaneous
R10425 T19389 T19390 arg1Of blocking,of
R10426 T19389 T19394 arg1Of blocking,in
R10427 T19389 T19398 arg1Of blocking,by
R10428 T19393 T19390 arg2Of activity,of
R10429 T19393 T19391 arg1Of activity,NF-κB
R10430 T19393 T19392 arg1Of activity,binding
R10431 T19397 T19394 arg2Of promoter,in
R10432 T19397 T19395 arg1Of promoter,the
R10433 T19397 T19396 arg1Of promoter,IL-17
R10434 T19399 T19400 arg1Of PDTC,and
R10435 T19400 T19398 arg2Of and,by
R10436 T19401 T19400 arg2Of LY294002,and
R10437 T19402 T19406 arg1Of Considering,and
R10438 T19405 T19402 arg2Of activities,Considering
R10439 T19405 T19403 arg1Of activities,its
R10440 T19405 T19404 arg1Of activities,proinflammatory
R10441 T19406 T19426 arg1Of and,is
R10442 T19408 T19406 arg2Of induction,and
R10443 T19408 T19407 arg1Of induction,successful
R10444 T19408 T19409 arg1Of induction,of
R10445 T19408 T19411 arg1Of induction,for
R10446 T19410 T19409 arg2Of anti-IL-17,of
R10447 T19412 T19411 arg2Of ameliorating,for
R10448 T19412 T19414 arg1Of ameliorating,in
R10449 T19412 T19420 arg1Of ameliorating,","
R10450 T19412 T19421 modOf ameliorating,understanding
R10451 T19413 T19412 arg2Of arthritis,ameliorating
R10452 T19416 T19414 arg2Of models,in
R10453 T19416 T19415 arg1Of models,animal
R10454 T19416 T19417 arg1Of models,[
R10455 T19418 T19417 arg2Of "2,6,34-36",[
R10456 T19419 T19417 arg3Of ],[
R10457 T19425 T19421 arg2Of pathway,understanding
R10458 T19425 T19422 arg1Of pathway,the
R10459 T19425 T19423 arg1Of pathway,IL-17
R10460 T19425 T19424 arg1Of pathway,signaling
R10461 T19429 T19426 arg2Of element,is
R10462 T19429 T19427 arg1Of element,an
R10463 T19429 T19428 arg1Of element,important
R10464 T19429 T19430 arg1Of element,of
R10465 T19431 T19430 arg2Of developing,of
R10466 T19434 T19431 arg2Of therapies,developing
R10467 T19434 T19432 arg1Of therapies,new
R10468 T19434 T19433 arg2Of therapies,targeted
R10469 T19434 T19435 arg1Of therapies,in
R10470 T19436 T19435 arg2Of RA,in

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T19454 2856-2861 Antecedent denotes TNF-α
T19453 2847-2851 Antecedent denotes IL-1
T19452 2863-2868 Anaphor denotes which
T19451 2364-2369 Antecedent denotes IL-23
T19450 2354-2359 Antecedent denotes IL-15
T19449 2338-2352 Anaphor denotes some cytokines
T19448 2151-2190 Antecedent denotes tumor necrosis factor-stimulated gene 6
T19447 2142-2146 Antecedent denotes IL-8
T19446 2136-2140 Antecedent denotes IL-6
T19445 2110-2127 Anaphor denotes several cytokines
T19444 1493-1498 Antecedent denotes IL-17
T19443 1612-1614 Anaphor denotes it
T19442 356-368 Antecedent denotes interferon-γ
T19441 347-351 Antecedent denotes IL-4
T19440 310-334 Anaphor denotes T cell-derived cytokines
T19439 255-260 Antecedent denotes TNF-α
T19438 246-250 Antecedent denotes IL-1
T19437 212-237 Anaphor denotes Proinflammatory cytokines
R10481 T19452 T19453 boundBy which,IL-1
R10482 T19452 T19454 boundBy which,TNF-α
R10471 T19437 T19438 boundBy Proinflammatory cytokines,IL-1
R10472 T19437 T19439 boundBy Proinflammatory cytokines,TNF-α
R10473 T19440 T19441 boundBy T cell-derived cytokines,IL-4
R10474 T19440 T19442 boundBy T cell-derived cytokines,interferon-γ
R10475 T19443 T19444 boundBy it,IL-17
R10476 T19445 T19446 boundBy several cytokines,IL-6
R10477 T19445 T19447 boundBy several cytokines,IL-8
R10478 T19445 T19448 boundBy several cytokines,tumor necrosis factor-stimulated gene 6
R10479 T19449 T19450 boundBy some cytokines,IL-15
R10480 T19449 T19451 boundBy some cytokines,IL-23

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T19476 2136-2140 Protein denotes IL-6
T19523 6003-6008 Protein denotes IL-17
T19522 5922-5927 Protein denotes IL-17
T19521 5809-5814 Protein denotes IL-17
T19520 5701-5706 Protein denotes IL-17
T19519 5610-5613 Protein denotes Akt
T19518 5551-5556 Protein denotes IL-17
T19517 5420-5423 Protein denotes Akt
T19516 5229-5233 Protein denotes AP-1
T19515 5194-5199 Protein denotes IL-17
T19514 5069-5074 Protein denotes IL-15
T19513 5063-5067 Protein denotes CD28
T19512 4983-4988 Protein denotes IL-17
T19511 4873-4876 Protein denotes Akt
T19510 4791-4794 Protein denotes Akt
T19509 4650-4655 Protein denotes IL-17
T19508 4356-4376 Protein denotes CREB-binding protein
T19507 4351-4355 Protein denotes p300
T19506 4227-4239 Protein denotes IκB kinase-β
T19505 4042-4047 Protein denotes IL-17
T19504 3829-3834 Protein denotes IL-17
T19503 3817-3820 Protein denotes CD3
T19502 3775-3780 Protein denotes IL-17
T19501 3583-3588 Protein denotes IL-17
T19500 3504-3509 Protein denotes IL-17
T19499 3400-3405 Protein denotes IL-17
T19498 3380-3384 Protein denotes CD28
T19497 3146-3151 Protein denotes MCP-1
T19496 3087-3092 Protein denotes TNF-α
T19495 3057-3062 Protein denotes IL-17
T19494 3032-3037 Protein denotes IL-15
T19493 2963-2968 Protein denotes IL-17
T19492 2856-2861 Protein denotes TNF-α
T19491 2847-2851 Protein denotes IL-1
T19490 2802-2807 Protein denotes IL-17
T19489 2770-2775 Protein denotes MCP-1
T19488 2761-2766 Protein denotes IL-15
T19487 2736-2741 Protein denotes IL-17
T19486 2664-2669 Protein denotes MCP-1
T19485 2654-2659 Protein denotes IL-15
T19484 2618-2622 Protein denotes CD28
T19483 2478-2483 Protein denotes IL-17
T19482 2399-2404 Protein denotes IL-17
T19481 2364-2369 Protein denotes IL-23
T19480 2354-2359 Protein denotes IL-15
T19479 2305-2310 Protein denotes IL-17
T19478 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T19477 2142-2146 Protein denotes IL-8
T19475 2058-2063 Protein denotes IL-17
T19474 1742-1747 Protein denotes IL-17
T19473 1659-1664 Protein denotes IL-23
T19472 1639-1642 Protein denotes CD8
T19471 1531-1534 Protein denotes CD4
T19470 1493-1498 Protein denotes IL-17
T19469 1404-1409 Protein denotes IL-17
T19468 1262-1267 Protein denotes IL-17
T19467 1204-1208 Protein denotes CD28
T19466 1162-1165 Protein denotes PHA
T19465 1096-1100 Protein denotes CD28
T19464 1046-1051 Protein denotes IL-17
T19463 992-997 Protein denotes IL-17
T19462 842-847 Protein denotes IL-17
T19461 753-758 Protein denotes IL-17
T19460 601-606 Protein denotes IL-17
T19459 356-368 Protein denotes interferon-γ
T19458 347-351 Protein denotes IL-4
T19457 255-260 Protein denotes TNF-α
T19456 246-250 Protein denotes IL-1
T19455 11-16 Protein denotes IL-17

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T20039 5229-5233 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T20038 5610-5613 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20037 5420-5423 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20036 4873-4876 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20035 4791-4794 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T20034 5610-5613 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20033 5420-5423 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20008 1639-1642 http://www.uniprot.org/uniprot/P01732 denotes CD8
T20007 1531-1534 http://www.uniprot.org/uniprot/P01730 denotes CD4
T20006 5063-5067 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20005 3380-3384 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20004 2618-2622 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20003 1204-1208 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20002 1096-1100 http://www.uniprot.org/uniprot/P10747 denotes CD28
T20001 5054-5057 http://www.uniprot.org/uniprot/P09693 denotes CD3
T20000 4905-4908 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19999 4030-4033 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19998 3817-3820 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19997 3371-3374 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19996 2609-2612 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19995 1195-1198 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19994 1087-1090 http://www.uniprot.org/uniprot/P09693 denotes CD3
T19993 5054-5057 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19992 4905-4908 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19991 4030-4033 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19990 3817-3820 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19989 3371-3374 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19988 2609-2612 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19987 1195-1198 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19986 1087-1090 http://www.uniprot.org/uniprot/P07766 denotes CD3
T19985 5054-5057 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19984 4905-4908 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19983 4030-4033 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19982 3817-3820 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19974 3817-3820 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19971 1195-1198 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19970 1087-1090 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19969 356-368 http://www.uniprot.org/uniprot/P01579 denotes interferon-γ
T19968 347-351 http://www.uniprot.org/uniprot/P05112 denotes IL-4
T19967 3087-3092 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19966 2856-2861 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19965 255-260 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T19964 2856-2859 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19963 255-258 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19962 6003-6008 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19961 5922-5927 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19960 5809-5814 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19959 5701-5706 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19958 5551-5556 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19957 5194-5199 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19956 4983-4988 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19955 4650-4655 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19954 4042-4047 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19953 3829-3834 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19952 3775-3780 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19951 3583-3588 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19950 3504-3509 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19949 3400-3405 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19948 3057-3062 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19947 2963-2968 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19946 2802-2807 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19945 2736-2741 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19944 2478-2483 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19943 2399-2404 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19942 2305-2310 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19941 2058-2063 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19940 1742-1747 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19939 1493-1498 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19938 1404-1409 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19937 1262-1267 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19936 1046-1051 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19935 992-997 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19934 842-847 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19933 753-758 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19932 601-606 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19931 11-16 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T19973 3371-3374 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19972 2609-2612 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19977 5054-5057 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19976 4905-4908 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19975 4030-4033 http://www.uniprot.org/uniprot/P20963 denotes CD3
T19981 3371-3374 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19980 2609-2612 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19979 1195-1198 http://www.uniprot.org/uniprot/P04234 denotes CD3
T19978 1087-1090 http://www.uniprot.org/uniprot/P04234 denotes CD3
T20032 4873-4876 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20031 4791-4794 http://www.uniprot.org/uniprot/P31751 denotes Akt
T20030 5610-5613 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20029 5420-5423 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20028 4873-4876 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20027 4791-4794 http://www.uniprot.org/uniprot/P31749 denotes Akt
T20026 4356-4376 http://www.uniprot.org/uniprot/Q92793 denotes CREB-binding protein
T20025 4356-4360 http://www.uniprot.org/uniprot/Q02930 denotes CREB
T20024 4356-4360 http://www.uniprot.org/uniprot/P15336 denotes CREB
T20023 4356-4360 http://www.uniprot.org/uniprot/O43889 denotes CREB
T20022 4356-4360 http://www.uniprot.org/uniprot/P16220 denotes CREB
T20021 4356-4360 http://www.uniprot.org/uniprot/Q8TEY5 denotes CREB
T20020 4356-4360 http://www.uniprot.org/uniprot/P18848 denotes CREB
T20019 4351-4355 http://www.uniprot.org/uniprot/Q09472 denotes p300
T20018 4227-4237 http://www.uniprot.org/uniprot/Q60680-2 denotes IκB kinase
T20017 4227-4237 http://www.uniprot.org/uniprot/O15111 denotes IκB kinase
T20016 5069-5074 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20015 3032-3037 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20014 2761-2766 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20013 2654-2659 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20012 2354-2359 http://www.uniprot.org/uniprot/P40933 denotes IL-15
T20011 2142-2146 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T20010 2136-2140 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T20009 1639-1642 http://www.uniprot.org/uniprot/P10966 denotes CD8

UBERON-AE

Id Subject Object Predicate Lexical cue
T17223 904-918 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluid
T17222 878-892 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluid

GO-BP

Id Subject Object Predicate Lexical cue
T18233 2216-2218 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T18232 2216-2218 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T18231 2216-2218 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T18230 2216-2218 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T18229 2216-2218 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T18228 2216-2218 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T18227 2216-2218 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T18226 2216-2218 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T18225 2216-2218 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T18224 2216-2218 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T18223 2216-2218 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T18222 2216-2218 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T18221 2157-2165 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T18220 2157-2165 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T18219 2157-2165 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T18218 2157-2165 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T18217 1469-1477 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T18216 1436-1444 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T18215 1335-1353 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T18214 5234-5253 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T18213 3657-3676 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T18212 5281-5298 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18211 3717-3734 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18210 3441-3458 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18209 805-822 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T18208 6009-6018 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18207 5281-5290 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18206 3717-3726 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18205 3628-3637 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18204 3441-3450 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18203 1213-1222 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18202 805-814 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18201 4650-4666 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18200 4042-4058 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18199 3829-3845 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18198 3583-3599 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18197 3057-3073 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18196 2963-2979 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18195 2802-2818 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18194 2399-2415 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18193 2305-2321 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18192 1742-1758 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18191 1262-1278 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18190 1046-1062 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18189 992-1008 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18188 753-769 http://purl.obolibrary.org/obo/GO_0032620 denotes IL-17 production
T18187 4650-4666 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18186 4042-4058 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18185 3829-3845 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18184 3583-3599 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18183 3057-3073 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18182 2963-2979 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18181 2802-2818 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18180 2399-2415 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18179 2305-2321 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18178 1742-1758 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18177 1262-1278 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18176 1046-1062 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18175 992-1008 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18174 753-769 http://purl.obolibrary.org/obo/GO_0032660 denotes IL-17 production
T18173 505-517 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18268 5628-5644 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18267 5281-5323 http://purl.obolibrary.org/obo/GO_0019221 denotes signaling pathway for cytokines/chemokines
T18266 5234-5261 http://purl.obolibrary.org/obo/GO_0035556 denotes signal transduction pathway
T18265 5234-5261 http://purl.obolibrary.org/obo/GO_0036499 denotes signal transduction pathway
T18264 5234-5261 http://purl.obolibrary.org/obo/GO_0036500 denotes signal transduction pathway
T18263 5234-5261 http://purl.obolibrary.org/obo/GO_0036498 denotes signal transduction pathway
T18262 4413-4428 http://purl.obolibrary.org/obo/GO_0000187 denotes MAPK activation
T18261 4409-4428 http://purl.obolibrary.org/obo/GO_1900745 denotes p38 MAPK activation
T18260 4555-4559 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18259 4413-4417 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18258 4112-4116 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18257 4551-4554 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18256 4409-4412 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18255 4284-4287 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18254 4256-4259 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18253 4209-4212 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18252 4108-4111 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18251 5605-5609 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18250 5389-5393 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18249 4958-4962 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18248 4749-4753 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18247 4583-4587 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18246 3891-3895 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18245 5241-5253 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T18244 3664-3676 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T18243 3467-3489 http://purl.obolibrary.org/obo/GO_0042089 denotes induction of cytokines
T18242 3245-3268 http://purl.obolibrary.org/obo/GO_0042117 denotes activation of monocytes
T18241 3342-3357 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T18240 3171-3186 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T18239 3146-3149 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18238 2770-2773 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18237 2664-2667 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18236 2779-2782 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T18235 2681-2684 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T18234 2584-2587 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR

GO-MF

Id Subject Object Predicate Lexical cue
T19605 5779-5792 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T19604 4467-4480 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T19603 4361-4376 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T19602 5785-5792 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19601 4473-4480 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19600 4361-4368 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T19599 4356-4368 http://purl.obolibrary.org/obo/GO_0008140 denotes CREB-binding
T19598 4555-4559 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19597 4413-4417 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19596 4112-4116 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T19595 4551-4554 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19594 4409-4412 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19593 4284-4287 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19592 4256-4259 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19591 4209-4212 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19590 4108-4111 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T19589 5605-5609 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19588 5389-5393 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19587 4958-4962 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19586 4749-4753 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19585 4583-4587 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19584 3891-3895 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T19583 3146-3149 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19582 2770-2773 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19581 2664-2667 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19580 5069-5074 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19579 3032-3037 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19578 2761-2766 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19577 2654-2659 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19576 2354-2359 http://purl.obolibrary.org/obo/GO_0016170 denotes IL-15
T19575 2216-2218 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T19574 2216-2218 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T19573 2216-2218 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T19572 2216-2218 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T19571 2216-2218 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T19570 2216-2218 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T19569 2216-2218 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T19568 2216-2218 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T19567 2216-2218 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T19566 2216-2218 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T19565 2216-2218 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T19564 2216-2218 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T19563 2142-2146 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T19562 2136-2140 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T19561 2364-2369 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T19560 1659-1664 http://purl.obolibrary.org/obo/GO_0045519 denotes IL-23
T19559 356-368 http://purl.obolibrary.org/obo/GO_0005133 denotes interferon-γ
T19558 347-351 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T19557 2847-2851 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T19556 246-250 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T19555 6003-6008 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19554 5922-5927 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19553 5809-5814 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19552 5701-5706 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19551 5551-5556 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19550 5194-5199 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19549 4983-4988 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19548 4650-4655 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19547 4042-4047 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19546 3829-3834 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19545 3775-3780 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19544 3583-3588 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19543 3504-3509 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19542 3400-3405 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19541 3057-3062 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19540 2963-2968 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19539 2802-2807 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19538 2736-2741 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19537 2478-2483 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19536 2399-2404 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19535 2305-2310 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19534 2058-2063 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19533 1742-1747 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19532 1493-1498 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19531 1404-1409 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19530 1262-1267 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19529 1046-1051 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19528 992-997 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19527 842-847 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19526 753-758 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19525 601-606 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T19524 11-16 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17

GO-CC

Id Subject Object Predicate Lexical cue
T19615 5507-5511 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19618 2779-2782 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T19617 2681-2684 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T19616 2584-2587 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T19614 3342-3346 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19613 3171-3175 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19612 2569-2573 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19611 1335-1339 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19610 1237-1241 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19609 657-661 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19608 533-537 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19607 312-316 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19606 44-48 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

sentences

Id Subject Object Predicate Lexical cue
T18172 5846-6094 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.
T18171 5570-5845 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T18170 5380-5569 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T18169 5212-5379 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T18168 4996-5211 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T18167 4859-4995 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T18166 4710-4858 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T18165 4600-4709 Sentence denotes The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments.
T18164 4383-4599 Sentence denotes Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation.
T18163 4214-4382 Sentence denotes In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33].
T18162 4128-4213 Sentence denotes It is interesting that a series of evidence supports crosstalk between NF-κB and p38.
T18161 4006-4127 Sentence denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor.
T18160 3793-4005 Sentence denotes We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation.
T18159 3648-3792 Sentence denotes By using signal transduction inhibitors, we therefore examined which signaling pathway was mainly involved in the induction of IL-17 in RA PBMC.
T18158 3428-3647 Sentence denotes Although the signaling pathway for the induction of cytokines/chemokines by IL-17 has been documented widely [8,30,31], no data have been available on how IL-17 production can be regulated by certain signaling pathways.
T18157 3299-3427 Sentence denotes As reported for normal individuals [25], T cell activation through anti-CD3/anti-CD28 also increases IL-17 induction in RA PBMC.
T18156 3113-3298 Sentence denotes Although there were no data that MCP-1 directly induces T cell activation, it might exert effects indirectly on T cells through the activation of monocytes/macrophages in PBMC cultures.
T18155 2981-3112 Sentence denotes Our data were consistent with a recent report that IL-15 triggered in vitro IL-17 production in PBMC, but TNF-α did not do so [13].
T18154 2834-2980 Sentence denotes In contrast, IL-1 and TNF-α, which are known to have proinflammatory properties and to be increased in RA joints, did not affect IL-17 production.
T18153 2754-2833 Sentence denotes Adding IL-15 or MCP-1 to TCR ligation augmented IL-17 production more markedly.
T18152 2624-2753 Sentence denotes Our studies demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC.
T18151 2425-2623 Sentence denotes We therefore investigated the in vitro production of IL-17 in RA PBMC responding to a variety of cytokines/chemokines and mitogens as well as T cell receptor (TCR) ligation using anti-CD3/anti-CD28.
T18150 2240-2424 Sentence denotes There are as yet few data available on the agents that stimulate IL-17 production in RA, although some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14].
T18149 2045-2239 Sentence denotes For example, IL-17 stimulates rheumatoid synoviocytes to secrete several cytokines such as IL-6, IL-8 and tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,28,29].
T18148 1871-2044 Sentence denotes A complex interaction between cells in inflamed RA joints might produce a variety of proinflammatory cytokines and chemokines, which also activate other cells in the joints.
T18147 1729-1870 Sentence denotes In addition, IL-17 production was significantly augmented by T cells recognizing type II collagen in a collagen-induced arthritis model [27].
T18146 1603-1728 Sentence denotes However, it can also be produced by CD8+ T cells via an IL-23 triggering mechanism in Gram-negative pulmonary infection [14].
T18145 1493-1602 Sentence denotes IL-17 is produced mainly by activated CD4+ T cells, especially for Th1/Th0 cells, not the Th2 phenotype [26].
T18144 1320-1492 Sentence denotes We found, by a cell proliferation assay (data not shown), that this upregulation of IL-17 might be due to increased cellular activity rather than to cellular proliferation.
T18143 1142-1319 Sentence denotes In our experiments, PHA as mitogens, as well as anti-CD3/anti-CD28 for signaling through the T cell receptor, increased IL-17 production from RA PBMC in a dose-dependent manner.
T18142 925-1141 Sentence denotes However, there are few data available on the agents that stimulate IL-17 production in RA, although the highest level of IL-17 production can be achieved by anti-CD3/anti-CD28 stimulation in healthy individuals [25].
T18141 832-924 Sentence denotes Levels of IL-17 were found to be higher in RA synovial fluid than in OA synovial fluid [15].
T18140 712-831 Sentence denotes In our studies, we tried to evaluate how IL-17 production is regulated in RA PBMC, and which signaling pathway it used.
T18139 584-711 Sentence denotes In this respect, IL-17 is appealing because it has been described as a T cell-derived cytokine with proinflammatory properties.
T18138 429-583 Sentence denotes Although T cells may have a role in the augmentation of rheumatoid synovial inflammation, the lack of T cell-derived cytokines has limited its importance.
T18137 212-428 Sentence denotes Proinflammatory cytokines such as IL-1 and TNF-α are abundant in rheumatoid synovium, whereas the T cell-derived cytokines, especially IL-4 and interferon-γ, have often proved difficult to detect in RA synovium [24].
T18136 97-211 Sentence denotes RA is characterized by hyperplasia of synovial lining cells and an intense infiltration by mononuclear cells [23].
T18135 11-96 Sentence denotes IL-17 was first described as a T cell product with proinflammatory properties [5,22].
T156 0-10 Sentence denotes Discussion
T157 11-96 Sentence denotes IL-17 was first described as a T cell product with proinflammatory properties [5,22].
T158 97-211 Sentence denotes RA is characterized by hyperplasia of synovial lining cells and an intense infiltration by mononuclear cells [23].
T159 212-428 Sentence denotes Proinflammatory cytokines such as IL-1 and TNF-α are abundant in rheumatoid synovium, whereas the T cell-derived cytokines, especially IL-4 and interferon-γ, have often proved difficult to detect in RA synovium [24].
T160 429-583 Sentence denotes Although T cells may have a role in the augmentation of rheumatoid synovial inflammation, the lack of T cell-derived cytokines has limited its importance.
T161 584-711 Sentence denotes In this respect, IL-17 is appealing because it has been described as a T cell-derived cytokine with proinflammatory properties.
T162 712-831 Sentence denotes In our studies, we tried to evaluate how IL-17 production is regulated in RA PBMC, and which signaling pathway it used.
T163 832-924 Sentence denotes Levels of IL-17 were found to be higher in RA synovial fluid than in OA synovial fluid [15].
T164 925-1141 Sentence denotes However, there are few data available on the agents that stimulate IL-17 production in RA, although the highest level of IL-17 production can be achieved by anti-CD3/anti-CD28 stimulation in healthy individuals [25].
T165 1142-1319 Sentence denotes In our experiments, PHA as mitogens, as well as anti-CD3/anti-CD28 for signaling through the T cell receptor, increased IL-17 production from RA PBMC in a dose-dependent manner.
T166 1320-1492 Sentence denotes We found, by a cell proliferation assay (data not shown), that this upregulation of IL-17 might be due to increased cellular activity rather than to cellular proliferation.
T167 1493-1602 Sentence denotes IL-17 is produced mainly by activated CD4+ T cells, especially for Th1/Th0 cells, not the Th2 phenotype [26].
T168 1603-1728 Sentence denotes However, it can also be produced by CD8+ T cells via an IL-23 triggering mechanism in Gram-negative pulmonary infection [14].
T169 1729-1870 Sentence denotes In addition, IL-17 production was significantly augmented by T cells recognizing type II collagen in a collagen-induced arthritis model [27].
T170 1871-2044 Sentence denotes A complex interaction between cells in inflamed RA joints might produce a variety of proinflammatory cytokines and chemokines, which also activate other cells in the joints.
T171 2045-2239 Sentence denotes For example, IL-17 stimulates rheumatoid synoviocytes to secrete several cytokines such as IL-6, IL-8 and tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,28,29].
T172 2240-2424 Sentence denotes There are as yet few data available on the agents that stimulate IL-17 production in RA, although some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14].
T173 2425-2623 Sentence denotes We therefore investigated the in vitro production of IL-17 in RA PBMC responding to a variety of cytokines/chemokines and mitogens as well as T cell receptor (TCR) ligation using anti-CD3/anti-CD28.
T174 2624-2753 Sentence denotes Our studies demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC.
T175 2754-2833 Sentence denotes Adding IL-15 or MCP-1 to TCR ligation augmented IL-17 production more markedly.
T176 2834-2980 Sentence denotes In contrast, IL-1 and TNF-α, which are known to have proinflammatory properties and to be increased in RA joints, did not affect IL-17 production.
T177 2981-3112 Sentence denotes Our data were consistent with a recent report that IL-15 triggered in vitro IL-17 production in PBMC, but TNF-α did not do so [13].
T178 3113-3298 Sentence denotes Although there were no data that MCP-1 directly induces T cell activation, it might exert effects indirectly on T cells through the activation of monocytes/macrophages in PBMC cultures.
T179 3299-3427 Sentence denotes As reported for normal individuals [25], T cell activation through anti-CD3/anti-CD28 also increases IL-17 induction in RA PBMC.
T180 3428-3647 Sentence denotes Although the signaling pathway for the induction of cytokines/chemokines by IL-17 has been documented widely [8,30,31], no data have been available on how IL-17 production can be regulated by certain signaling pathways.
T181 3648-3792 Sentence denotes By using signal transduction inhibitors, we therefore examined which signaling pathway was mainly involved in the induction of IL-17 in RA PBMC.
T182 3793-4005 Sentence denotes We identified that anti-CD3-induced IL-17 production in RA PBMC was significantly hampered by the PI3K inhibitor LY294002 and the NF-κB inhibitor PDTC to comparable levels of basal production without stimulation.
T183 4006-4127 Sentence denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition of SB203580, a p38 MAPK inhibitor.
T184 4128-4213 Sentence denotes It is interesting that a series of evidence supports crosstalk between NF-κB and p38.
T185 4214-4382 Sentence denotes In myocytes, IκB kinase-β is activated by p38 [32], and the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33].
T186 4383-4599 Sentence denotes Our results revealed that p38 MAPK activation was not affected by LY294002, whereas NF-κB binding activity was decreased by LY294002, which provided the evidence for a p38 MAPK pathway independent of PI3K activation.
T187 4600-4709 Sentence denotes The direct relationship between p38 and NF-κB for IL-17 production needs to be studied in future experiments.
T188 4710-4858 Sentence denotes The search for a downstream pathway of PI3K seemed to have a maximal response of Akt activation at 1 hour and a gradual loss of activity at 2 hours.
T189 4859-4995 Sentence denotes The fact that Akt is phosphorylated upon anti-CD3 stimulation suggests the possible involvement of PI3K in the induction of IL-17 in RA.
T190 4996-5211 Sentence denotes In view of the fact that NF-κB was also activated by anti-CD3/anti-CD28, IL-15 or mitogens in our experiments, it is most likely that the NF-κB pathway is also actively involved in the induction of IL-17 in RA PBMC.
T191 5212-5379 Sentence denotes In contrast, the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines, was not activated in our experiments (data not shown).
T192 5380-5569 Sentence denotes Although PI3K and its downstream kinase Akt in association with NF-κB have been reported to deliver activating signals in many cell types, the data on the signal inducing IL-17 are lacking.
T193 5570-5845 Sentence denotes Our data clearly demonstrated that PI3K/Akt and resultant NF-κB activation could be an important arbitrator of the upregulation of IL-17 in RA, on the basis of our experiments showing simultaneous blocking of NF-κB binding activity in the IL-17 promoter by PDTC and LY294002.
T194 5846-6094 Sentence denotes Considering its proinflammatory activities and successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36], understanding the IL-17 signaling pathway is an important element of developing new targeted therapies in RA.

ICD10

Id Subject Object Predicate Lexical cue
T19620 5945-5954 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T19619 1849-1858 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

simple1

Id Subject Object Predicate Lexical cue
T19930 6003-6008 Protein denotes IL-17
T19929 5922-5927 Protein denotes IL-17
T19928 5809-5814 Protein denotes IL-17
T19927 5701-5706 Protein denotes IL-17
T19926 5610-5613 Protein denotes Akt
T19925 5551-5556 Protein denotes IL-17
T19924 5420-5423 Protein denotes Akt
T19923 5229-5233 Protein denotes AP-1
T19922 5194-5199 Protein denotes IL-17
T19921 5069-5074 Protein denotes IL-15
T19920 5063-5067 Protein denotes CD28
T19919 4983-4988 Protein denotes IL-17
T19918 4873-4876 Protein denotes Akt
T19917 4791-4794 Protein denotes Akt
T19916 4650-4655 Protein denotes IL-17
T19915 4356-4376 Protein denotes CREB-binding protein
T19914 4351-4355 Protein denotes p300
T19913 4227-4239 Protein denotes IκB kinase-β
T19912 4042-4047 Protein denotes IL-17
T19911 3829-3834 Protein denotes IL-17
T19910 3817-3820 Protein denotes CD3
T19909 3775-3780 Protein denotes IL-17
T19908 3583-3588 Protein denotes IL-17
T19907 3504-3509 Protein denotes IL-17
T19906 3400-3405 Protein denotes IL-17
T19905 3380-3384 Protein denotes CD28
T19904 3146-3151 Protein denotes MCP-1
T19903 3087-3092 Protein denotes TNF-α
T19902 3057-3062 Protein denotes IL-17
T19901 3032-3037 Protein denotes IL-15
T19900 2963-2968 Protein denotes IL-17
T19899 2856-2861 Protein denotes TNF-α
T19898 2847-2851 Protein denotes IL-1
T19897 2802-2807 Protein denotes IL-17
T19896 2770-2775 Protein denotes MCP-1
T19895 2761-2766 Protein denotes IL-15
T19894 2736-2741 Protein denotes IL-17
T19893 2664-2669 Protein denotes MCP-1
T19892 2654-2659 Protein denotes IL-15
T19891 2618-2622 Protein denotes CD28
T19890 2478-2483 Protein denotes IL-17
T19889 2399-2404 Protein denotes IL-17
T19888 2364-2369 Protein denotes IL-23
T19887 2354-2359 Protein denotes IL-15
T19886 2305-2310 Protein denotes IL-17
T19885 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T19884 2142-2146 Protein denotes IL-8
T19883 2136-2140 Protein denotes IL-6
T19882 2058-2063 Protein denotes IL-17
T19881 1742-1747 Protein denotes IL-17
T19880 1659-1664 Protein denotes IL-23
T19879 1639-1642 Protein denotes CD8
T19878 1531-1534 Protein denotes CD4
T19877 1493-1498 Protein denotes IL-17
T19876 1404-1409 Protein denotes IL-17
T19875 1262-1267 Protein denotes IL-17
T19874 1204-1208 Protein denotes CD28
T19873 1162-1165 Protein denotes PHA
T19872 1096-1100 Protein denotes CD28
T19871 1046-1051 Protein denotes IL-17
T19870 992-997 Protein denotes IL-17
T19869 842-847 Protein denotes IL-17
T19868 753-758 Protein denotes IL-17
T19867 601-606 Protein denotes IL-17
T19866 356-368 Protein denotes interferon-γ
T19865 347-351 Protein denotes IL-4
T19864 255-260 Protein denotes TNF-α
T19863 246-250 Protein denotes IL-1
T19862 11-16 Protein denotes IL-17

DLUT931

Id Subject Object Predicate Lexical cue
T20286 5904-5913 Positive_regulation denotes induction
T20285 5685-5697 Positive_regulation denotes upregulation
T20284 5561-5568 Negative_regulation denotes lacking
T20283 5542-5550 Positive_regulation denotes inducing
T20282 5427-5438 Binding denotes association
T20281 5333-5342 Positive_regulation denotes activated
T20280 5165-5173 Regulation denotes involved
T20279 5181-5190 Positive_regulation denotes induction
T20278 4943-4954 Regulation denotes involvement
T20274 4795-4805 Positive_regulation denotes activation
T20273 4656-4666 Gene_expression denotes production
T20272 4243-4252 Positive_regulation denotes activated
T20271 4063-4076 Negative_regulation denotes downregulated
T20270 4025-4041 Positive_regulation denotes anti-CD3-induced
T20269 4048-4058 Gene_expression denotes production
T20268 3875-3883 Negative_regulation denotes hampered
T20267 3821-3828 Positive_regulation denotes induced
T20266 3835-3845 Gene_expression denotes production
T20265 3746-3754 Regulation denotes involved
T20264 3762-3771 Positive_regulation denotes induction
T20263 3607-3616 Regulation denotes regulated
T20262 3589-3599 Gene_expression denotes production
T20261 3467-3476 Positive_regulation denotes induction
T20260 3406-3415 Positive_regulation denotes induction
T20259 3038-3047 Positive_regulation denotes triggered
T20258 3063-3073 Gene_expression denotes production
T20257 2956-2962 Regulation denotes affect
T20256 2969-2979 Gene_expression denotes production
T20255 2792-2801 Positive_regulation denotes augmented
T20254 2808-2818 Gene_expression denotes production
T20253 2754-2760 Positive_regulation denotes Adding
T20252 2708-2717 Positive_regulation denotes increased
T20251 2722-2732 Gene_expression denotes production
T20250 2464-2474 Gene_expression denotes production
T20249 2390-2398 Regulation denotes regulate
T20248 2295-2304 Positive_regulation denotes stimulate
T20247 2405-2415 Gene_expression denotes production
T20246 2311-2321 Gene_expression denotes production
T20245 2102-2109 Localization denotes secrete
T20244 1777-1786 Positive_regulation denotes augmented
T20243 1748-1758 Gene_expression denotes production
T20242 1627-1635 Gene_expression denotes produced
T20241 1502-1510 Gene_expression denotes produced
T20240 1388-1400 Positive_regulation denotes upregulation
T20239 1252-1261 Positive_regulation denotes increased
T20238 1268-1278 Gene_expression denotes production
T20237 982-991 Positive_regulation denotes stimulate
T20236 1052-1062 Gene_expression denotes production
T20235 998-1008 Gene_expression denotes production
T20234 773-782 Regulation denotes regulated
T20233 759-769 Gene_expression denotes production
T20232 6003-6008 Protein denotes IL-17
T20231 5922-5927 Protein denotes IL-17
T20230 5809-5814 Protein denotes IL-17
T20229 5701-5706 Protein denotes IL-17
T20228 5610-5613 Protein denotes Akt
T20227 5551-5556 Protein denotes IL-17
T20226 5420-5423 Protein denotes Akt
T20225 5229-5233 Protein denotes AP-1
T20224 5194-5199 Protein denotes IL-17
T20223 5069-5074 Protein denotes IL-15
T20222 5063-5067 Protein denotes CD28
T20221 4983-4988 Protein denotes IL-17
T20220 4873-4876 Protein denotes Akt
T20219 4791-4794 Protein denotes Akt
T20218 4650-4655 Protein denotes IL-17
T20217 4356-4376 Protein denotes CREB-binding protein
T20216 4351-4355 Protein denotes p300
T20215 4227-4239 Protein denotes IκB kinase-β
T20214 4042-4047 Protein denotes IL-17
T20213 3829-3834 Protein denotes IL-17
T20212 3817-3820 Protein denotes CD3
T20211 3775-3780 Protein denotes IL-17
T20210 3583-3588 Protein denotes IL-17
T20209 3504-3509 Protein denotes IL-17
T20208 3400-3405 Protein denotes IL-17
T20207 3380-3384 Protein denotes CD28
T20206 3146-3151 Protein denotes MCP-1
T20205 3087-3092 Protein denotes TNF-α
T20204 3057-3062 Protein denotes IL-17
T20203 3032-3037 Protein denotes IL-15
T20202 2963-2968 Protein denotes IL-17
T20201 2856-2861 Protein denotes TNF-α
T20200 2847-2851 Protein denotes IL-1
T20199 2802-2807 Protein denotes IL-17
T20198 2770-2775 Protein denotes MCP-1
T20197 2761-2766 Protein denotes IL-15
T20196 2736-2741 Protein denotes IL-17
T20195 2664-2669 Protein denotes MCP-1
T20194 2654-2659 Protein denotes IL-15
T20193 2618-2622 Protein denotes CD28
T20192 2478-2483 Protein denotes IL-17
T20191 2399-2404 Protein denotes IL-17
T20190 2364-2369 Protein denotes IL-23
T20189 2354-2359 Protein denotes IL-15
T20188 2305-2310 Protein denotes IL-17
T20187 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T20186 2142-2146 Protein denotes IL-8
T20185 2136-2140 Protein denotes IL-6
T20184 2058-2063 Protein denotes IL-17
T20183 1742-1747 Protein denotes IL-17
T20182 1659-1664 Protein denotes IL-23
T20181 1639-1642 Protein denotes CD8
T20180 1531-1534 Protein denotes CD4
T20179 1493-1498 Protein denotes IL-17
T20178 1404-1409 Protein denotes IL-17
T20177 1262-1267 Protein denotes IL-17
T20176 1204-1208 Protein denotes CD28
T20175 1162-1165 Protein denotes PHA
T20174 992-997 Protein denotes IL-17
T20173 1096-1100 Protein denotes CD28
T20172 1046-1051 Protein denotes IL-17
T20171 842-847 Protein denotes IL-17
T20170 753-758 Protein denotes IL-17
T20169 601-606 Protein denotes IL-17
T20168 356-368 Protein denotes interferon-γ
T20167 347-351 Protein denotes IL-4
T20166 255-260 Protein denotes TNF-α
T20165 246-250 Protein denotes IL-1
T20164 11-16 Protein denotes IL-17
T20276 4880-4894 Phosphorylation denotes phosphorylated
T20275 4779-4787 Regulation denotes response
T20277 4970-4979 Positive_regulation denotes induction
R10663 T20170 T20233 themeOf IL-17,production
R10664 T20172 T20236 themeOf IL-17,production
R10665 T20174 T20235 themeOf IL-17,production
R10666 T20175 T20239 causeOf PHA,increased
R10667 T20177 T20238 themeOf IL-17,production
R10668 T20178 T20240 themeOf IL-17,upregulation
R10669 T20179 T20241 themeOf IL-17,produced
R10670 T20182 T20242 themeOf IL-23,produced
R10671 T20183 T20243 themeOf IL-17,production
R10672 T20184 T20245 themeOf IL-17,secrete
R10673 T20185 T20245 themeOf IL-6,secrete
R10674 T20186 T20245 themeOf IL-8,secrete
R10675 T20187 T20245 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10676 T20188 T20246 themeOf IL-17,production
R10677 T20191 T20247 themeOf IL-17,production
R10678 T20192 T20250 themeOf IL-17,production
R10679 T20194 T20252 causeOf IL-15,increased
R10680 T20195 T20252 causeOf MCP-1,increased
R10681 T20196 T20251 themeOf IL-17,production
R10682 T20197 T20253 themeOf IL-15,Adding
R10683 T20198 T20253 themeOf MCP-1,Adding
R10684 T20199 T20254 themeOf IL-17,production
R10685 T20200 T20257 causeOf IL-1,affect
R10686 T20201 T20257 causeOf TNF-α,affect
R10687 T20202 T20256 themeOf IL-17,production
R10688 T20203 T20259 causeOf IL-15,triggered
R10689 T20204 T20258 themeOf IL-17,production
R10690 T20208 T20260 themeOf IL-17,induction
R10691 T20209 T20261 themeOf IL-17,induction
R10692 T20210 T20262 themeOf IL-17,production
R10693 T20211 T20264 themeOf IL-17,induction
R10694 T20212 T20267 causeOf CD3,induced
R10695 T20213 T20266 themeOf IL-17,production
R10696 T20214 T20269 themeOf IL-17,production
R10697 T20215 T20272 themeOf IκB kinase-β,activated
R10698 T20218 T20273 themeOf IL-17,production
R10699 T20219 T20274 themeOf Akt,activation
R10700 T20220 T20276 themeOf Akt,phosphorylated
R10701 T20221 T20277 themeOf IL-17,induction
R10702 T20224 T20279 themeOf IL-17,induction
R10703 T20225 T20281 themeOf AP-1,activated
R10704 T20226 T20282 themeOf Akt,association
R10705 T20227 T20283 themeOf IL-17,inducing
R10706 T20229 T20285 themeOf IL-17,upregulation
R10707 T20231 T20286 themeOf IL-17,induction
R10708 T20233 T20234 themeOf production,regulated
R10709 T20235 T20237 themeOf production,stimulate
R10710 T20238 T20239 themeOf production,increased
R10711 T20243 T20244 themeOf production,augmented
R10712 T20246 T20248 themeOf production,stimulate
R10713 T20247 T20249 themeOf production,regulate
R10714 T20251 T20252 themeOf production,increased
R10715 T20251 T20252 themeOf production,increased
R10716 T20254 T20255 themeOf production,augmented
R10717 T20256 T20257 themeOf production,affect
R10718 T20256 T20257 themeOf production,affect
R10719 T20258 T20259 themeOf production,triggered
R10720 T20262 T20263 themeOf production,regulated
R10721 T20264 T20265 themeOf induction,involved
R10722 T20266 T20267 themeOf production,induced
R10723 T20267 T20268 themeOf induced,hampered
R10724 T20269 T20270 themeOf production,anti-CD3-induced
R10725 T20270 T20271 themeOf anti-CD3-induced,downregulated
R10726 T20274 T20275 themeOf activation,response
R10727 T20277 T20278 themeOf induction,involvement
R10728 T20279 T20280 themeOf induction,involved
R10729 T20283 T20284 themeOf inducing,lacking

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Speculation
T21863 5427-5449 Binding denotes association with NF-κB
T21862 3057-3073 Gene_expression denotes IL-17 production
T21861 4650-4666 Gene_expression denotes IL-17 production
T21860 4270-4381 Positive_regulation denotes the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33] true
T21859 4966-4994 Gene_expression denotes the induction of IL-17 in RA
T21858 4966-4994 Positive_regulation denotes the induction of IL-17 in RA
T21857 1262-1291 Gene_expression denotes IL-17 production from RA PBMC
T21856 4873-4894 Phosphorylation denotes Akt is phosphorylated
T21855 1742-1758 Gene_expression denotes IL-17 production
T21854 3812-3845 Gene_expression denotes anti-CD3-induced IL-17 production
T21853 2802-2818 Gene_expression denotes IL-17 production
T21852 653-710 Gene_expression denotes a T cell-derived cytokine with proinflammatory properties
T21851 4791-4805 Positive_regulation denotes Akt activation
T21850 5681-5713 Positive_regulation denotes the upregulation of IL-17 in RA,
T21849 3375-3426 Positive_regulation denotes anti-CD28 also increases IL-17 induction in RA PBMC
T21848 3375-3426 Positive_regulation denotes anti-CD28 also increases IL-17 induction in RA PBMC
T21847 2399-2423 Gene_expression denotes IL-17 production [13,14]
T21846 753-769 Gene_expression denotes IL-17 production
T21845 1252-1318 Positive_regulation denotes increased IL-17 production from RA PBMC in a dose-dependent manner
T21844 4214-4264 Positive_regulation denotes In myocytes, IκB kinase-β is activated by p38 [32]
T21843 2636-2752 Positive_regulation denotes demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
T21842 2636-2752 Positive_regulation denotes demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
T21841 992-1015 Gene_expression denotes IL-17 production in RA,
T21840 4020-4092 Positive_regulation denotes that anti-CD3-induced IL-17 production was downregulated by the addition
T21839 5893-5983 Gene_expression denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21838 5893-5983 Positive_regulation denotes successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]
T21837 5174-5210 Positive_regulation denotes in the induction of IL-17 in RA PBMC
T21836 5174-5210 Gene_expression denotes in the induction of IL-17 in RA PBMC
T21835 4025-4058 Gene_expression denotes anti-CD3-induced IL-17 production
T21834 2567-2589 Localization denotes T cell receptor (TCR)
T21833 1046-1062 Gene_expression denotes IL-17 production
T21832 4900-4920 Positive_regulation denotes anti-CD3 stimulation
T21831 306-335 Gene_expression denotes the T cell-derived cytokines,
T21830 3583-3646 Regulation denotes IL-17 production can be regulated by certain signaling pathways
T21829 1231-1250 Localization denotes the T cell receptor
T21828 5618-5644 Positive_regulation denotes resultant NF-κB activation
T21827 1493-1543 Gene_expression denotes IL-17 is produced mainly by activated CD4+ T cells
T21826 5531-5556 Positive_regulation denotes the signal inducing IL-17
T21825 5531-5556 Gene_expression denotes the signal inducing IL-17
T21824 2464-2494 Gene_expression denotes production of IL-17 in RA PBMC
T21823 4409-4458 Regulation denotes p38 MAPK activation was not affected by LY294002,
T21822 3400-3426 Gene_expression denotes IL-17 induction in RA PBMC
T21821 3400-3426 Positive_regulation denotes IL-17 induction in RA PBMC
T21820 3755-3780 Gene_expression denotes in the induction of IL-17
T21819 3755-3780 Positive_regulation denotes in the induction of IL-17
T21818 2338-2423 Regulation denotes some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]
T21817 2718-2752 Gene_expression denotes the production of IL-17 in RA PBMC
T21816 2305-2328 Gene_expression denotes IL-17 production in RA,
T21815 4270-4287 Positive_regulation denotes the activated p38
T21814 4006-4092 Negative_regulation denotes We also found that anti-CD3-induced IL-17 production was downregulated by the addition
T21813 4580-4598 Positive_regulation denotes of PI3K activation
T21812 1383-1409 Positive_regulation denotes this upregulation of IL-17
T21811 528-555 Gene_expression denotes of T cell-derived cytokines
T21810 2963-2979 Gene_expression denotes IL-17 production
T21809 3463-3509 Gene_expression denotes the induction of cytokines/chemokines by IL-17
T21808 3463-3509 Positive_regulation denotes the induction of cytokines/chemokines by IL-17
T21807 3583-3599 Gene_expression denotes IL-17 production
T21806 4749-4753 Protein denotes PI3K
T21805 4351-4376 Protein denotes p300/CREB-binding protein
T21804 2664-2693 Protein denotes MCP-1 as well as TCR ligation
T21803 2354-2359 Protein denotes IL-15
T21802 4209-4212 Protein denotes p38
T21801 5605-5613 Protein denotes PI3K/Akt
T21800 1521-1543 Entity denotes activated CD4+ T cells
T21799 1145-1198 Protein denotes our experiments, PHA as mitogens, as well as anti-CD3
T21798 653-710 Protein denotes a T cell-derived cytokine with proinflammatory properties
T21797 3284-3288 Entity denotes PBMC
T21796 4980-4988 Protein denotes of IL-17
T21795 5016-5026 Protein denotes that NF-κB
T21794 4199-4204 Protein denotes NF-κB
T21793 4042-4047 Protein denotes IL-17
T21792 2305-2310 Protein denotes IL-17
T21791 4409-4428 Protein denotes p38 MAPK activation
T21790 4108-4111 Protein denotes p38
T21789 4253-4264 Protein denotes by p38 [32]
T21788 5809-5814 Protein denotes IL-17
T21787 2364-2369 Protein denotes IL-23
T21786 5203-5210 Entity denotes RA PBMC
T21785 842-847 Protein denotes IL-17
T21784 655-669 Entity denotes T cell-derived
T21783 5628-5633 Protein denotes NF-κB
T21782 2522-2542 Protein denotes cytokines/chemokines
T21781 992-997 Protein denotes IL-17
T21780 5551-5556 Protein denotes IL-17
T21779 3849-3851 Protein denotes RA
T21778 411-413 Protein denotes RA
T21777 1401-1409 Protein denotes of IL-17
T21776 3087-3092 Protein denotes TNF-α
T21775 255-260 Protein denotes TNF-α
T21774 2613-2622 Protein denotes anti-CD28
T21773 1190-1198 Protein denotes anti-CD3
T21772 5058-5067 Protein denotes anti-CD28
T21771 2118-2135 Protein denotes cytokines such as
T21770 2654-2659 Protein denotes IL-15
T21769 135-156 Entity denotes synovial lining cells
T21768 2547-2612 Entity denotes mitogens as well as T cell receptor (TCR) ligation using anti-CD3
T21767 1919-1921 Protein denotes RA
T21766 1493-1498 Protein denotes IL-17
T21765 2584-2587 Protein denotes TCR
T21764 4905-4908 Protein denotes CD3
T21763 531-545 Entity denotes T cell-derived
T21762 4108-4126 Entity denotes p38 MAPK inhibitor
T21761 3400-3405 Protein denotes IL-17
T21760 3891-3895 Protein denotes PI3K
T21759 5439-5449 Protein denotes with NF-κB
T21758 528-555 Protein denotes of T cell-derived cytokines
T21757 2202-2232 Entity denotes prostaglandin E2 in vitro [12,
T21756 786-793 Entity denotes RA PBMC
T21755 4549-4598 Protein denotes a p38 MAPK pathway independent of PI3K activation
T21754 5313-5323 Protein denotes chemokines
T21753 2058-2063 Protein denotes IL-17
T21752 438-445 Entity denotes T cells
T21751 5389-5393 Protein denotes PI3K
T21750 3141-3151 Protein denotes that MCP-1
T21749 5398-5423 Protein denotes its downstream kinase Akt
T21748 3490-3500 Protein denotes chemokines
T21747 1815-1826 Entity denotes II collagen
T21746 2475-2483 Protein denotes of IL-17
T21745 1235-1241 Entity denotes T cell
T21744 1046-1051 Protein denotes IL-17
T21743 2770-2775 Protein denotes MCP-1
T21742 1169-1178 Entity denotes mitogens,
T21741 2399-2404 Protein denotes IL-17
T21740 4504-4516 Entity denotes by LY294002,
T21739 5130-5147 Protein denotes the NF-κB pathway
T21738 1893-1928 Entity denotes between cells in inflamed RA joints
T21737 2847-2851 Protein denotes IL-1
T21736 5502-5517 Entity denotes many cell types
T21735 4351-4376 Protein denotes p300/CREB-binding protein
T21734 3480-3500 Protein denotes cytokines/chemokines
T21733 1284-1291 Entity denotes RA PBMC
T21732 1832-1848 Entity denotes collagen-induced
T21731 2745-2747 Protein denotes RA
T21730 4302-4381 Protein denotes NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]
T21729 3419-3426 Entity denotes RA PBMC
T21728 2487-2489 Protein denotes RA
T21727 4108-4126 Protein denotes p38 MAPK inhibitor
T21726 3887-3914 Entity denotes the PI3K inhibitor LY294002
T21725 2733-2741 Protein denotes of IL-17
T21724 2018-2029 Entity denotes other cells
T21723 2567-2588 Protein denotes T cell receptor (TCR)
T21722 2856-2861 Protein denotes TNF-α
T21721 2487-2494 Entity denotes RA PBMC
T21720 2151-2232 Protein denotes tumor necrosis factor-stimulated gene 6 as well as prostaglandin E2 in vitro [12,
T21719 5698-5706 Protein denotes of IL-17
T21718 2086-2098 Entity denotes synoviocytes
T21717 347-351 Protein denotes IL-4
T21716 5610-5613 Protein denotes Akt
T21715 4549-4598 Protein denotes a p38 MAPK pathway independent of PI3K activation
T21714 901-903 Entity denotes OA
T21713 3057-3062 Protein denotes IL-17
T21712 5078-5086 Entity denotes mitogens
T21711 2802-2807 Protein denotes IL-17
T21710 1560-1574 Entity denotes Th1/Th0 cells,
T21709 2522-2542 Protein denotes cytokines/chemokines
T21708 5225-5324 Protein denotes the AP-1 signal transduction pathway, another important signaling pathway for cytokines/chemokines,
T21707 2745-2752 Entity denotes RA PBMC
T21706 11-16 Protein denotes IL-17
T21705 1972-1981 Protein denotes cytokines
T21704 325-335 Protein denotes cytokines,
T21703 5805-5823 Entity denotes the IL-17 promoter
T21702 3657-3688 Entity denotes signal transduction inhibitors,
T21701 1262-1267 Protein denotes IL-17
T21700 4025-4041 Protein denotes anti-CD3-induced
T21699 601-606 Protein denotes IL-17
T21698 1986-1997 Protein denotes chemokines,
T21697 42-48 Entity denotes T cell
T21696 1231-1250 Protein denotes the T cell receptor
T21695 5203-5205 Protein denotes RA
T21694 4356-4376 Protein denotes CREB-binding protein
T21693 1199-1251 Protein denotes anti-CD28 for signaling through the T cell receptor,
T21692 3366-3374 Protein denotes anti-CD3
T21691 4333-4340 Entity denotes histone
T21690 2338-2370 Protein denotes some cytokines (IL-15 and IL-23)
T21689 4227-4239 Protein denotes IκB kinase-β
T21688 875-877 Protein denotes RA
T21687 2567-2573 Entity denotes T cell
T21686 4409-4412 Protein denotes p38
T21685 1659-1664 Protein denotes IL-23
T21684 5836-5844 Entity denotes LY294002
T21683 3772-3780 Protein denotes of IL-17
T21682 2142-2146 Protein denotes IL-8
T21681 4650-4655 Protein denotes IL-17
T21680 3501-3509 Protein denotes by IL-17
T21679 4583-4587 Protein denotes PI3K
T21678 786-788 Protein denotes RA
T21677 3480-3500 Protein denotes cytokines/chemokines
T21676 5031-5057 Protein denotes also activated by anti-CD3
T21675 2325-2327 Protein denotes RA
T21674 4873-4876 Protein denotes Akt
T21673 3027-3037 Protein denotes that IL-15
T21672 5263-5323 Protein denotes another important signaling pathway for cytokines/chemokines
T21671 2202-2215 Entity denotes prostaglandin
T21670 5398-5423 Protein denotes its downstream kinase Akt
T21669 2532-2542 Protein denotes chemokines
T21668 3887-3914 Entity denotes the PI3K inhibitor LY294002
T21667 4333-4381 Protein denotes histone acetylase p300/CREB-binding protein [33]
T21666 3829-3834 Protein denotes IL-17
T21665 4955-4962 Protein denotes of PI3K
T21664 3225-3232 Entity denotes T cells
T21663 5605-5613 Protein denotes PI3K/Akt
T21662 2937-2939 Protein denotes RA
T21661 4446-4458 Entity denotes by LY294002,
T21660 2136-2140 Protein denotes IL-6
T21659 5398-5423 Protein denotes its downstream kinase Akt
T21658 306-316 Entity denotes the T cell
T21657 3375-3384 Protein denotes anti-CD28
T21656 4992-4994 Protein denotes RA
T21655 3784-3786 Protein denotes RA
T21654 2681-2684 Protein denotes TCR
T21653 3583-3588 Protein denotes IL-17
T21652 3849-3856 Entity denotes RA PBMC
T21645 4270-4287 Protein denotes the activated p38
T21644 1636-1651 Entity denotes by CD8+ T cells
T21643 2761-2766 Protein denotes IL-15
T21642 1012-1014 Protein denotes RA
T21641 2604-2612 Protein denotes anti-CD3
T21640 753-758 Protein denotes IL-17
T21639 3919-3938 Entity denotes the NF-κB inhibitor
T21638 4791-4794 Protein denotes Akt
T21637 1871-1955 Entity denotes A complex interaction between cells in inflamed RA joints might produce a variety of
T21636 1742-1747 Protein denotes IL-17
T21635 212-245 Protein denotes Proinflammatory cytokines such as
T21634 6003-6008 Protein denotes IL-17
T21633 4640-4645 Protein denotes NF-κB
T21632 3077-3081 Entity denotes PBMC
T21631 3256-3297 Entity denotes of monocytes/macrophages in PBMC cultures
T21630 1284-1286 Protein denotes RA
T21629 2779-2782 Protein denotes TCR
T21628 97-99 Protein denotes RA
T21627 3784-3791 Entity denotes RA PBMC
T21626 185-210 Entity denotes by mononuclear cells [23]
T21625 5710-5712 Protein denotes RA
T21624 1815-1826 Entity denotes II collagen
T21623 4632-4635 Protein denotes p38
T21622 4217-4225 Entity denotes myocytes
T21621 5914-5927 Protein denotes of anti-IL-17
T21620 3419-3421 Protein denotes RA
T21619 1790-1797 Entity denotes T cells
T21618 5069-5074 Protein denotes IL-15
T21651 5191-5199 Protein denotes of IL-17
T21650 6091-6093 Protein denotes RA
T21649 212-250 Protein denotes Proinflammatory cytokines such as IL-1
T21648 356-369 Entity denotes interferon-γ,
T21647 2963-2968 Protein denotes IL-17
T21646 1564-1567 Entity denotes Th0
R11924 T21621 T21838 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11925 T21621 T21839 themeOf of anti-IL-17,"successful induction of anti-IL-17 for ameliorating arthritis in animal models [2,6,34-36]"
R11931 T21651 T21836 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11932 T21636 T21855 themeOf IL-17,IL-17 production
R11933 T21638 T21851 themeOf Akt,Akt activation
R11934 T21640 T21846 themeOf IL-17,IL-17 production
R11935 T21651 T21837 themeOf of IL-17,in the induction of IL-17 in RA PBMC
R11936 T21653 T21807 themeOf IL-17,IL-17 production
R11937 T21657 T21848 causeOf anti-CD28,anti-CD28 also increases IL-17 induction in RA PBMC
R11938 T21645 T21815 themeOf the activated p38,the activated p38
R11939 T21647 T21810 themeOf IL-17,IL-17 production
R11940 T21657 T21849 causeOf anti-CD28,anti-CD28 also increases IL-17 induction in RA PBMC
R11941 T21661 T21823 causeOf "by LY294002,","p38 MAPK activation was not affected by LY294002,"
R11942 T21666 T21854 themeOf IL-17,anti-CD3-induced IL-17 production
R11943 T21758 T21811 themeOf of T cell-derived cytokines,of T cell-derived cytokines
R11944 T21674 T21856 themeOf Akt,Akt is phosphorylated
R11945 T21759 T21863 themeOf with NF-κB,association with NF-κB
R11946 T21761 T21821 themeOf IL-17,IL-17 induction in RA PBMC
R11947 T21761 T21822 themeOf IL-17,IL-17 induction in RA PBMC
R11948 T21764 T21832 themeOf CD3,anti-CD3 stimulation
R11949 T21766 T21827 themeOf IL-17,IL-17 is produced mainly by activated CD4+ T cells
R11950 T21677 T21808 themeOf cytokines/chemokines,the induction of cytokines/chemokines by IL-17
R11951 T21770 T21843 causeOf IL-15,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11952 T21677 T21809 themeOf cytokines/chemokines,the induction of cytokines/chemokines by IL-17
R11953 T21679 T21813 themeOf PI3K,of PI3K activation
R11954 T21777 T21812 themeOf of IL-17,this upregulation of IL-17
R11955 T21680 T21808 causeOf by IL-17,the induction of cytokines/chemokines by IL-17
R11956 T21780 T21825 themeOf IL-17,the signal inducing IL-17
R11957 T21780 T21826 themeOf IL-17,the signal inducing IL-17
R11958 T21781 T21841 themeOf IL-17,"IL-17 production in RA,"
R11959 T21681 T21861 themeOf IL-17,IL-17 production
R11960 T21783 T21828 themeOf NF-κB,resultant NF-κB activation
R11961 T21683 T21819 themeOf of IL-17,in the induction of IL-17
R11962 T21683 T21820 themeOf of IL-17,in the induction of IL-17
R11963 T21789 T21844 causeOf by p38 [32],"In myocytes, IκB kinase-β is activated by p38 [32]"
R11964 T21687 T21834 locationOf T cell,T cell receptor (TCR)
R11965 T21792 T21816 themeOf IL-17,"IL-17 production in RA,"
R11966 T21793 T21835 themeOf IL-17,anti-CD3-induced IL-17 production
R11967 T21796 T21858 themeOf of IL-17,the induction of IL-17 in RA
R11968 T21796 T21859 themeOf of IL-17,the induction of IL-17 in RA
R11969 T21689 T21844 themeOf IκB kinase-β,"In myocytes, IκB kinase-β is activated by p38 [32]"
R11970 T21798 T21852 themeOf a T cell-derived cytokine with proinflammatory properties,a T cell-derived cytokine with proinflammatory properties
R11971 T21690 T21818 causeOf some cytokines (IL-15 and IL-23),"some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]"
R11972 T21696 T21829 themeOf the T cell receptor,the T cell receptor
R11973 T21804 T21842 causeOf MCP-1 as well as TCR ligation,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11974 T21807 T21830 themeOf IL-17 production,IL-17 production can be regulated by certain signaling pathways
R11975 T21701 T21857 themeOf IL-17,IL-17 production from RA PBMC
R11976 T21817 T21842 themeOf the production of IL-17 in RA PBMC,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11977 T21817 T21843 themeOf the production of IL-17 in RA PBMC,demonstrated that IL-15 and MCP-1 as well as TCR ligation significantly increased the production of IL-17 in RA PBMC
R11978 T21821 T21848 themeOf IL-17 induction in RA PBMC,anti-CD28 also increases IL-17 induction in RA PBMC
R11979 T21822 T21849 themeOf IL-17 induction in RA PBMC,anti-CD28 also increases IL-17 induction in RA PBMC
R11980 T21703 T21788 partOf the IL-17 promoter,IL-17
R11981 T21704 T21831 themeOf "cytokines,","the T cell-derived cytokines,"
R11982 T21711 T21853 themeOf IL-17,IL-17 production
R11983 T21835 T21814 themeOf anti-CD3-induced IL-17 production,We also found that anti-CD3-induced IL-17 production was downregulated by the addition
R11984 T21835 T21840 themeOf anti-CD3-induced IL-17 production,that anti-CD3-induced IL-17 production was downregulated by the addition
R11985 T21713 T21862 themeOf IL-17,IL-17 production
R11986 T21719 T21850 themeOf of IL-17,"the upregulation of IL-17 in RA,"
R11987 T21847 T21818 themeOf "IL-17 production [13,14]","some cytokines (IL-15 and IL-23) have been known to regulate IL-17 production [13,14]"
R11988 T21723 T21834 themeOf T cell receptor (TCR),T cell receptor (TCR)
R11989 T21725 T21817 themeOf of IL-17,the production of IL-17 in RA PBMC
R11990 T21730 T21860 themeOf NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33],the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33]
R11991 T21857 T21845 themeOf IL-17 production from RA PBMC,increased IL-17 production from RA PBMC in a dose-dependent manner
R11992 T21741 T21847 themeOf IL-17,"IL-17 production [13,14]"
R11993 T21744 T21833 themeOf IL-17,IL-17 production
R11994 T21745 T21829 locationOf T cell,the T cell receptor
R11995 T21746 T21824 themeOf of IL-17,production of IL-17 in RA PBMC

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T21445 6093-6094 . denotes .
T21444 6091-6093 NNP denotes RA
T21443 6088-6090 IN denotes in
T21442 6078-6087 NNS denotes therapies
T21441 6069-6077 JJ denotes targeted
T21440 6065-6068 JJ denotes new
T21439 6054-6064 VBG denotes developing
T21438 6051-6053 IN denotes of
T21437 6043-6050 NN denotes element
T21436 6033-6042 JJ denotes important
T21435 6030-6032 DT denotes an
T21434 6027-6029 VBZ denotes is
T21433 6019-6026 NN denotes pathway
T21432 6009-6018 VBG denotes signaling
T21431 6003-6008 NNP denotes IL-17
T21430 5999-6002 DT denotes the
T21429 5985-5998 VBG denotes understanding
T21428 5983-5984 , denotes ,
T21427 5982-5983 NNP denotes ]
T21426 5973-5982 CD denotes 2,6,34-36
T21425 5972-5973 NNP denotes [
T21424 5965-5971 NNS denotes models
T21423 5958-5964 NN denotes animal
T21422 5955-5957 IN denotes in
T21421 5945-5954 NNS denotes arthritis
T21420 5932-5944 VBG denotes ameliorating
T21419 5928-5931 IN denotes for
T21418 5917-5927 JJ denotes anti-IL-17
T21417 5914-5916 IN denotes of
T21416 5904-5913 NN denotes induction
T21415 5893-5903 JJ denotes successful
T21414 5889-5892 CC denotes and
T21413 5878-5888 NNS denotes activities
T21412 5862-5877 JJ denotes proinflammatory
T21411 5858-5861 PRP$ denotes its
T21410 5846-5857 VBG denotes Considering
T21409 5844-5845 . denotes .
T21408 5836-5844 NNP denotes LY294002
T21407 5832-5835 CC denotes and
T21406 5827-5831 NNP denotes PDTC
T21405 5824-5826 IN denotes by
T21404 5815-5823 NN denotes promoter
T21403 5809-5814 NNP denotes IL-17
T21402 5805-5808 DT denotes the
T21401 5802-5804 IN denotes in
T21400 5793-5801 NN denotes activity
T21399 5785-5792 JJ denotes binding
T21398 5779-5784 JJ denotes NF-κB
T21397 5776-5778 IN denotes of
T21396 5767-5775 VBG denotes blocking
T21395 5754-5766 JJ denotes simultaneous
T21394 5746-5753 VBG denotes showing
T21393 5734-5745 NNS denotes experiments
T21392 5730-5733 PRP$ denotes our
T21391 5727-5729 IN denotes of
T21390 5721-5726 NN denotes basis
T21389 5717-5720 DT denotes the
T21388 5714-5716 IN denotes on
T21387 5712-5713 , denotes ,
T21386 5710-5712 NNP denotes RA
T21385 5707-5709 IN denotes in
T21384 5701-5706 NNP denotes IL-17
T21383 5698-5700 IN denotes of
T21382 5685-5697 NN denotes upregulation
T21381 5681-5684 DT denotes the
T21380 5678-5680 IN denotes of
T21379 5667-5677 NN denotes arbitrator
T21378 5657-5666 JJ denotes important
T21377 5654-5656 DT denotes an
T21376 5651-5653 VB denotes be
T21375 5645-5650 MD denotes could
T21374 5634-5644 NN denotes activation
T21373 5628-5633 NN denotes NF-κB
T21372 5618-5627 JJ denotes resultant
T21371 5614-5617 CC denotes and
T21370 5605-5613 NNP denotes PI3K/Akt
T21369 5600-5604 IN denotes that
T21368 5587-5599 VBD denotes demonstrated
T21367 5579-5586 RB denotes clearly
T21366 5574-5578 NNS denotes data
T21365 5570-5573 PRP$ denotes Our
T21364 5568-5569 . denotes .
T21363 5561-5568 VBG denotes lacking
T21362 5557-5560 VBP denotes are
T21361 5551-5556 NNP denotes IL-17
T21360 5542-5550 VBG denotes inducing
T21359 5535-5541 NN denotes signal
T21358 5531-5534 DT denotes the
T21357 5528-5530 IN denotes on
T21356 5523-5527 NNS denotes data
T21355 5519-5522 DT denotes the
T21354 5517-5518 , denotes ,
T21353 5512-5517 NNS denotes types
T21352 5507-5511 NN denotes cell
T21351 5502-5506 JJ denotes many
T21350 5499-5501 IN denotes in
T21349 5491-5498 NNS denotes signals
T21348 5480-5490 VBG denotes activating
T21347 5472-5479 VB denotes deliver
T21346 5469-5471 TO denotes to
T21345 5460-5468 VBN denotes reported
T21344 5455-5459 VBN denotes been
T21343 5450-5454 VBP denotes have
T21342 5444-5449 NNP denotes NF-κB
T21341 5439-5443 IN denotes with
T21340 5427-5438 NN denotes association
T21339 5424-5426 IN denotes in
T21338 5420-5423 NNP denotes Akt
T21337 5413-5419 NN denotes kinase
T21336 5402-5412 JJ denotes downstream
T21335 5398-5401 PRP$ denotes its
T21334 5394-5397 CC denotes and
T21333 5389-5393 NNP denotes PI3K
T21332 5380-5388 IN denotes Although
T21331 5378-5379 . denotes .
T21330 5377-5378 -RRB- denotes )
T21329 5372-5377 VBN denotes shown
T21328 5368-5371 RB denotes not
T21327 5363-5367 NNS denotes data
T21326 5362-5363 -LRB- denotes (
T21325 5350-5361 NNS denotes experiments
T21324 5346-5349 PRP$ denotes our
T21323 5343-5345 IN denotes in
T21322 5333-5342 VBN denotes activated
T21321 5329-5332 RB denotes not
T21320 5325-5328 VBD denotes was
T21319 5323-5324 , denotes ,
T21318 5303-5323 NNS denotes cytokines/chemokines
T21317 5299-5302 IN denotes for
T21316 5291-5298 NN denotes pathway
T21315 5281-5290 VBG denotes signaling
T21314 5271-5280 JJ denotes important
T21313 5263-5270 DT denotes another
T21312 5261-5262 , denotes ,
T21311 5254-5261 NN denotes pathway
T21310 5241-5253 NN denotes transduction
T21309 5234-5240 NN denotes signal
T21308 5229-5233 NNP denotes AP-1
T21307 5225-5228 DT denotes the
T21306 5223-5224 , denotes ,
T21305 5215-5223 NN denotes contrast
T21304 5212-5214 IN denotes In
T21303 5210-5211 . denotes .
T21302 5206-5210 NNP denotes PBMC
T21301 5203-5205 NNP denotes RA
T21300 5200-5202 IN denotes in
T21299 5194-5199 NNP denotes IL-17
T21298 5191-5193 IN denotes of
T21297 5181-5190 NN denotes induction
T21296 5177-5180 DT denotes the
T21295 5174-5176 IN denotes in
T21294 5165-5173 VBN denotes involved
T21293 5156-5164 RB denotes actively
T21292 5151-5155 RB denotes also
T21291 5148-5150 VBZ denotes is
T21290 5140-5147 NN denotes pathway
T21289 5134-5139 NNP denotes NF-κB
T21288 5130-5133 DT denotes the
T21287 5125-5129 IN denotes that
T21286 5118-5124 JJ denotes likely
T21285 5113-5117 RBS denotes most
T21284 5110-5112 VBZ denotes is
T21283 5107-5109 PRP denotes it
T21282 5105-5106 , denotes ,
T21281 5094-5105 NNS denotes experiments
T21280 5090-5093 PRP$ denotes our
T21279 5087-5089 IN denotes in
T21278 5078-5086 NNS denotes mitogens
T21277 5075-5077 CC denotes or
T21276 5069-5074 NN denotes IL-15
T21275 5067-5068 , denotes ,
T21274 5058-5067 NN denotes anti-CD28
T21273 5057-5058 NN denotes /
T21272 5049-5057 JJ denotes anti-CD3
T21271 5046-5048 IN denotes by
T21270 5036-5045 VBN denotes activated
T21269 5031-5035 RB denotes also
T21268 5027-5030 VBD denotes was
T21267 5021-5026 NNP denotes NF-κB
T21266 5016-5020 IN denotes that
T21265 5011-5015 NN denotes fact
T21264 5007-5010 DT denotes the
T21263 5004-5006 IN denotes of
T21262 4999-5003 NN denotes view
T21261 4996-4998 IN denotes In
T21260 4994-4995 . denotes .
T21259 4992-4994 NNP denotes RA
T21258 4989-4991 IN denotes in
T21257 4983-4988 NNP denotes IL-17
T21256 4980-4982 IN denotes of
T21255 4970-4979 NN denotes induction
T21254 4966-4969 DT denotes the
T21253 4963-4965 IN denotes in
T21252 4958-4962 NNP denotes PI3K
T21251 4955-4957 IN denotes of
T21250 4943-4954 NN denotes involvement
T21249 4934-4942 JJ denotes possible
T21248 4930-4933 DT denotes the
T21247 4921-4929 VBZ denotes suggests
T21246 4909-4920 NN denotes stimulation
T21245 4900-4908 JJ denotes anti-CD3
T21244 4895-4899 IN denotes upon
T21243 4880-4894 VBN denotes phosphorylated
T21242 4877-4879 VBZ denotes is
T21139 4288-4291 MD denotes can
T21138 4284-4287 NN denotes p38
T21137 4274-4283 VBN denotes activated
T21136 4270-4273 DT denotes the
T21135 4266-4269 CC denotes and
T21134 4264-4265 , denotes ,
T21133 4263-4264 NNP denotes ]
T21132 4261-4263 CD denotes 32
T21131 4260-4261 NNP denotes [
T21130 4256-4259 CD denotes p38
T21129 4253-4255 IN denotes by
T21128 4243-4252 VBN denotes activated
T21127 4240-4242 VBZ denotes is
T21126 4231-4239 NN denotes kinase-β
T21125 4227-4230 NNP denotes IκB
T21124 4225-4226 , denotes ,
T21123 4217-4225 NNS denotes myocytes
T21122 4214-4216 IN denotes In
T21121 4212-4213 . denotes .
T21120 4209-4212 CD denotes p38
T21119 4205-4208 CC denotes and
T21118 4199-4204 NNP denotes NF-κB
T21117 4191-4198 IN denotes between
T21116 4181-4190 NN denotes crosstalk
T21115 4172-4180 VBZ denotes supports
T21114 4163-4171 NN denotes evidence
T21113 4160-4162 IN denotes of
T21112 4153-4159 NN denotes series
T21111 4151-4152 DT denotes a
T21110 4146-4150 IN denotes that
T21109 4134-4145 JJ denotes interesting
T21108 4131-4133 VBZ denotes is
T21107 4128-4130 PRP denotes It
T21106 4126-4127 . denotes .
T21105 4117-4126 NN denotes inhibitor
T21104 4112-4116 NNP denotes MAPK
T21103 4108-4111 JJ denotes p38
T21102 4106-4107 DT denotes a
T21101 4104-4105 , denotes ,
T21100 4096-4104 NNP denotes SB203580
T21099 4093-4095 IN denotes of
T21098 4084-4092 NN denotes addition
T21097 4080-4083 DT denotes the
T21096 4077-4079 IN denotes by
T21095 4063-4076 VBN denotes downregulated
T21094 4059-4062 VBD denotes was
T21093 4048-4058 NN denotes production
T21092 4042-4047 NN denotes IL-17
T21091 4025-4041 JJ denotes anti-CD3-induced
T21090 4020-4024 IN denotes that
T21089 4014-4019 VBD denotes found
T21088 4009-4013 RB denotes also
T21087 4006-4008 PRP denotes We
T21086 4004-4005 . denotes .
T21085 3993-4004 NN denotes stimulation
T21084 3985-3992 IN denotes without
T21083 3974-3984 NN denotes production
T21082 3968-3973 JJ denotes basal
T21081 3965-3967 IN denotes of
T21080 3958-3964 NNS denotes levels
T21079 3947-3957 JJ denotes comparable
T21078 3944-3946 TO denotes to
T21077 3939-3943 NNP denotes PDTC
T21076 3929-3938 NN denotes inhibitor
T21075 3923-3928 NNP denotes NF-κB
T21074 3919-3922 DT denotes the
T21073 3915-3918 CC denotes and
T21072 3906-3914 NNP denotes LY294002
T21071 3896-3905 NN denotes inhibitor
T21070 3891-3895 NNP denotes PI3K
T21069 3887-3890 DT denotes the
T21068 3884-3886 IN denotes by
T21067 3875-3883 VBN denotes hampered
T21066 3861-3874 RB denotes significantly
T21065 3857-3860 VBD denotes was
T21064 3852-3856 NNP denotes PBMC
T21063 3849-3851 NNP denotes RA
T21062 3846-3848 IN denotes in
T21061 3835-3845 NN denotes production
T21060 3829-3834 NN denotes IL-17
T21059 3812-3828 JJ denotes anti-CD3-induced
T21058 3807-3811 IN denotes that
T21057 3796-3806 VBD denotes identified
T21056 3793-3795 PRP denotes We
T21055 3791-3792 . denotes .
T21054 3787-3791 NNP denotes PBMC
T21053 3784-3786 NNP denotes RA
T21052 3781-3783 IN denotes in
T21051 3775-3780 NNP denotes IL-17
T21050 3772-3774 IN denotes of
T21049 3762-3771 NN denotes induction
T21048 3758-3761 DT denotes the
T21047 3755-3757 IN denotes in
T21046 3746-3754 VBN denotes involved
T21045 3739-3745 RB denotes mainly
T21044 3735-3738 VBD denotes was
T21043 3727-3734 NN denotes pathway
T21042 3717-3726 VBG denotes signaling
T21041 3711-3716 WDT denotes which
T21040 3702-3710 VBD denotes examined
T21039 3692-3701 RB denotes therefore
T21038 3689-3691 PRP denotes we
T21037 3687-3688 , denotes ,
T21036 3677-3687 NNS denotes inhibitors
T21035 3664-3676 NN denotes transduction
T21034 3657-3663 NN denotes signal
T21033 3651-3656 VBG denotes using
T21032 3648-3650 IN denotes By
T21031 3646-3647 . denotes .
T21030 3638-3646 NNS denotes pathways
T21029 3628-3637 VBG denotes signaling
T21028 3620-3627 JJ denotes certain
T21027 3617-3619 IN denotes by
T21026 3607-3616 VBN denotes regulated
T21025 3604-3606 VB denotes be
T21024 3600-3603 MD denotes can
T21023 3589-3599 NN denotes production
T21022 3583-3588 JJ denotes IL-17
T21021 3579-3582 WRB denotes how
T21020 3576-3578 IN denotes on
T21019 3566-3575 JJ denotes available
T21018 3561-3565 VBN denotes been
T21017 3556-3560 VBP denotes have
T21016 3551-3555 NNS denotes data
T21015 3548-3550 DT denotes no
T21014 3546-3547 , denotes ,
T21013 3545-3546 NNP denotes ]
T21012 3538-3545 CD denotes 8,30,31
T21011 3537-3538 NNP denotes [
T21010 3530-3536 RB denotes widely
T21009 3519-3529 VBN denotes documented
T21008 3514-3518 VBN denotes been
T21007 3510-3513 VBZ denotes has
T21006 3504-3509 NNP denotes IL-17
T21005 3501-3503 IN denotes by
T21004 3480-3500 NNS denotes cytokines/chemokines
T21003 3477-3479 IN denotes of
T21002 3467-3476 NN denotes induction
T21001 3463-3466 DT denotes the
T21000 3459-3462 IN denotes for
T20999 3451-3458 NN denotes pathway
T20998 3441-3450 VBG denotes signaling
T20997 3437-3440 DT denotes the
T20996 3428-3436 IN denotes Although
T20995 3426-3427 . denotes .
T20994 3422-3426 NNP denotes PBMC
T20993 3419-3421 NNP denotes RA
T20992 3416-3418 IN denotes in
T20991 3406-3415 NN denotes induction
T20990 3400-3405 NNP denotes IL-17
T20989 3390-3399 VBZ denotes increases
T20988 3385-3389 RB denotes also
T20987 3375-3384 NN denotes anti-CD28
T20986 3374-3375 NN denotes /
T20985 3366-3374 JJ denotes anti-CD3
T20984 3358-3365 IN denotes through
T20983 3347-3357 NN denotes activation
T20982 3342-3346 NN denotes cell
T20981 3340-3341 NNP denotes T
T20980 3338-3339 , denotes ,
T20979 3337-3338 NNP denotes ]
T20978 3335-3337 CD denotes 25
T20977 3334-3335 NNP denotes [
T20976 3322-3333 NNS denotes individuals
T20975 3315-3321 JJ denotes normal
T20974 3311-3314 IN denotes for
T20973 3302-3310 VBN denotes reported
T20972 3299-3301 IN denotes As
T20971 3297-3298 . denotes .
T20970 3289-3297 NNS denotes cultures
T20969 3284-3288 NNP denotes PBMC
T20968 3281-3283 IN denotes in
T20967 3259-3280 NNS denotes monocytes/macrophages
T20966 3256-3258 IN denotes of
T20965 3245-3255 NN denotes activation
T20964 3241-3244 DT denotes the
T20963 3233-3240 IN denotes through
T20962 3227-3232 NNS denotes cells
T20961 3225-3226 NNP denotes T
T20960 3222-3224 IN denotes on
T20959 3211-3221 RB denotes indirectly
T20958 3203-3210 NNS denotes effects
T20957 3197-3202 VB denotes exert
T20956 3191-3196 MD denotes might
T20955 3188-3190 PRP denotes it
T20954 3186-3187 , denotes ,
T20953 3176-3186 NN denotes activation
T20952 3171-3175 NN denotes cell
T20951 3169-3170 NNP denotes T
T20950 3161-3168 VBZ denotes induces
T20949 3152-3160 RB denotes directly
T20948 3146-3151 NNP denotes MCP-1
T20947 3141-3145 WDT denotes that
T20946 3136-3140 NNS denotes data
T20945 3133-3135 DT denotes no
T20944 3128-3132 VBD denotes were
T20943 3122-3127 EX denotes there
T20942 3113-3121 IN denotes Although
T20941 3111-3112 . denotes .
T20940 3110-3111 NN denotes ]
T20939 3108-3110 CD denotes 13
T20938 3107-3108 JJ denotes [
T20937 3104-3106 RB denotes so
T20936 3101-3103 VB denotes do
T20935 3097-3100 RB denotes not
T20934 3093-3096 VBD denotes did
T20933 3087-3092 NNP denotes TNF-α
T20932 3083-3086 CC denotes but
T20931 3081-3082 , denotes ,
T20930 3077-3081 NNP denotes PBMC
T20929 3074-3076 IN denotes in
T20917 2995-3005 JJ denotes consistent
T20916 2990-2994 VBD denotes were
T20915 2985-2989 NNS denotes data
T20914 2981-2984 PRP$ denotes Our
T20913 2979-2980 . denotes .
T20912 2969-2979 NN denotes production
T20911 2963-2968 JJ denotes IL-17
T20910 2956-2962 VB denotes affect
T20909 2952-2955 RB denotes not
T20908 2948-2951 VBD denotes did
T20907 2946-2947 , denotes ,
T20906 2940-2946 NNS denotes joints
T20905 2937-2939 NNP denotes RA
T20904 2934-2936 IN denotes in
T20903 2924-2933 VBN denotes increased
T20902 2921-2923 VB denotes be
T20901 2918-2920 TO denotes to
T20900 2914-2917 CC denotes and
T20899 2903-2913 NNS denotes properties
T20898 2887-2902 JJ denotes proinflammatory
T20897 2882-2886 VB denotes have
T20896 2879-2881 TO denotes to
T20895 2873-2878 VBN denotes known
T20894 2869-2872 VBP denotes are
T20893 2863-2868 WDT denotes which
T20892 2861-2862 , denotes ,
T20891 2856-2861 NNP denotes TNF-α
T20890 2852-2855 CC denotes and
T20889 2847-2851 NNP denotes IL-1
T20888 2845-2846 , denotes ,
T20887 2837-2845 NN denotes contrast
T20886 2834-2836 IN denotes In
T20885 2832-2833 . denotes .
T20884 2824-2832 RB denotes markedly
T20883 2819-2823 RBR denotes more
T20882 2808-2818 NN denotes production
T20881 2802-2807 JJ denotes IL-17
T20880 2792-2801 VBD denotes augmented
T20879 2783-2791 NN denotes ligation
T20878 2779-2782 NNP denotes TCR
T20877 2776-2778 TO denotes to
T20876 2770-2775 NN denotes MCP-1
T20875 2767-2769 CC denotes or
T20874 2761-2766 NN denotes IL-15
T20873 2754-2760 VBG denotes Adding
T20872 2752-2753 . denotes .
T20871 2748-2752 NNP denotes PBMC
T20870 2745-2747 NNP denotes RA
T20869 2742-2744 IN denotes in
T21236 4852-4857 NNS denotes hours
T21235 4850-4851 CD denotes 2
T21234 4847-4849 IN denotes at
T21233 4838-4846 NN denotes activity
T21232 4835-4837 IN denotes of
T21231 4830-4834 NN denotes loss
T21230 4822-4829 JJ denotes gradual
T21229 4820-4821 DT denotes a
T21228 4816-4819 CC denotes and
T21227 4811-4815 NN denotes hour
T21226 4809-4810 CD denotes 1
T21225 4806-4808 IN denotes at
T21224 4795-4805 NN denotes activation
T21223 4791-4794 NNP denotes Akt
T21222 4788-4790 IN denotes of
T21221 4779-4787 NN denotes response
T21220 4771-4778 JJ denotes maximal
T21219 4769-4770 DT denotes a
T21218 4764-4768 VB denotes have
T21217 4761-4763 TO denotes to
T21216 4754-4760 VBD denotes seemed
T21215 4749-4753 NNP denotes PI3K
T21214 4746-4748 IN denotes of
T21213 4738-4745 NN denotes pathway
T21212 4727-4737 JJ denotes downstream
T21211 4725-4726 DT denotes a
T21210 4721-4724 IN denotes for
T21209 4714-4720 NN denotes search
T21208 4710-4713 DT denotes The
T21207 4708-4709 . denotes .
T21206 4697-4708 NNS denotes experiments
T21205 4690-4696 JJ denotes future
T21204 4687-4689 IN denotes in
T21203 4679-4686 VBN denotes studied
T21202 4676-4678 VB denotes be
T21201 4673-4675 TO denotes to
T21200 4667-4672 VBZ denotes needs
T21199 4656-4666 NN denotes production
T21198 4650-4655 NNP denotes IL-17
T21197 4646-4649 IN denotes for
T21196 4640-4645 NNP denotes NF-κB
T21195 4636-4639 CC denotes and
T21194 4632-4635 CD denotes p38
T21193 4624-4631 IN denotes between
T21192 4611-4623 NN denotes relationship
T21191 4604-4610 JJ denotes direct
T21190 4600-4603 DT denotes The
T21189 4598-4599 . denotes .
T21188 4588-4598 NN denotes activation
T21187 4583-4587 CD denotes PI3K
T21186 4580-4582 IN denotes of
T21185 4568-4579 JJ denotes independent
T21184 4560-4567 NN denotes pathway
T21183 4555-4559 NNP denotes MAPK
T21182 4551-4554 JJ denotes p38
T21181 4549-4550 DT denotes a
T21180 4545-4548 IN denotes for
T21179 4536-4544 NN denotes evidence
T21178 4532-4535 DT denotes the
T21177 4523-4531 VBD denotes provided
T21176 4517-4522 WDT denotes which
T21175 4515-4516 , denotes ,
T21174 4507-4515 NNP denotes LY294002
T21173 4504-4506 IN denotes by
T21172 4494-4503 VBN denotes decreased
T21171 4490-4493 VBD denotes was
T21170 4481-4489 NN denotes activity
T21169 4473-4480 JJ denotes binding
T21168 4467-4472 NNP denotes NF-κB
T21167 4459-4466 IN denotes whereas
T21166 4457-4458 , denotes ,
T21165 4449-4457 NNP denotes LY294002
T21164 4446-4448 IN denotes by
T21163 4437-4445 VBN denotes affected
T21162 4433-4436 RB denotes not
T21161 4429-4432 VBD denotes was
T21160 4418-4428 NN denotes activation
T21159 4413-4417 NNP denotes MAPK
T21158 4409-4412 CD denotes p38
T21157 4404-4408 IN denotes that
T21156 4395-4403 VBD denotes revealed
T21155 4387-4394 NNS denotes results
T21154 4383-4386 PRP$ denotes Our
T21153 4381-4382 . denotes .
T21152 4380-4381 NNP denotes ]
T20868 2736-2741 NNP denotes IL-17
T20867 2733-2735 IN denotes of
T20866 2722-2732 NN denotes production
T20865 2718-2721 DT denotes the
T20864 2708-2717 VBD denotes increased
T20863 2694-2707 RB denotes significantly
T20862 2685-2693 NN denotes ligation
T20861 2681-2684 NNP denotes TCR
T20860 2678-2680 IN denotes as
T20859 2673-2677 RB denotes well
T20858 2670-2672 RB denotes as
T20857 2664-2669 NNP denotes MCP-1
T20856 2660-2663 CC denotes and
T20855 2654-2659 NNP denotes IL-15
T20854 2649-2653 IN denotes that
T20853 2636-2648 VBD denotes demonstrated
T20852 2628-2635 NNS denotes studies
T20851 2624-2627 PRP$ denotes Our
T20850 2622-2623 . denotes .
T20849 2613-2622 NN denotes anti-CD28
T20848 2612-2613 NN denotes /
T20847 2604-2612 JJ denotes anti-CD3
T20846 2598-2603 VBG denotes using
T20845 2589-2597 NN denotes ligation
T20844 2587-2588 -RRB- denotes )
T20843 2584-2587 NNP denotes TCR
T20842 2583-2584 -LRB- denotes (
T20841 2574-2582 NN denotes receptor
T20840 2569-2573 NN denotes cell
T20839 2567-2568 NNP denotes T
T20838 2564-2566 IN denotes as
T20837 2559-2563 RB denotes well
T20836 2556-2558 RB denotes as
T20835 2547-2555 NNS denotes mitogens
T20834 2543-2546 CC denotes and
T20833 2522-2542 NNS denotes cytokines/chemokines
T20832 2519-2521 IN denotes of
T20831 2511-2518 NN denotes variety
T20830 2509-2510 DT denotes a
T20829 2506-2508 TO denotes to
T20828 2495-2505 VBG denotes responding
T20827 2490-2494 NNP denotes PBMC
T20826 2487-2489 NNP denotes RA
T20825 2484-2486 IN denotes in
T20824 2478-2483 NNP denotes IL-17
T20823 2475-2477 IN denotes of
T20822 2464-2474 NN denotes production
T20821 2458-2463 NN denotes vitro
T20820 2455-2457 IN denotes in
T20819 2451-2454 DT denotes the
T20818 2438-2450 VBD denotes investigated
T20817 2428-2437 RB denotes therefore
T20816 2425-2427 PRP denotes We
T20815 2423-2424 . denotes .
T20814 2422-2423 NNP denotes ]
T20813 2417-2422 CD denotes 13,14
T20812 2416-2417 NNP denotes [
T20811 2405-2415 NN denotes production
T20810 2399-2404 JJ denotes IL-17
T20809 2390-2398 VB denotes regulate
T20808 2387-2389 TO denotes to
T20807 2381-2386 VBN denotes known
T20806 2376-2380 VBN denotes been
T20805 2371-2375 VBP denotes have
T20804 2369-2370 -RRB- denotes )
T20803 2364-2369 NN denotes IL-23
T20802 2360-2363 CC denotes and
T20801 2354-2359 NN denotes IL-15
T20800 2353-2354 -LRB- denotes (
T20799 2343-2352 NNS denotes cytokines
T20798 2338-2342 DT denotes some
T20797 2329-2337 IN denotes although
T20796 2327-2328 , denotes ,
T20795 2325-2327 NNP denotes RA
T20794 2322-2324 IN denotes in
T20793 2311-2321 NN denotes production
T20792 2305-2310 JJ denotes IL-17
T20791 2295-2304 VBP denotes stimulate
T20790 2290-2294 WDT denotes that
T20789 2283-2289 NNS denotes agents
T20788 2279-2282 DT denotes the
T20787 2276-2278 IN denotes on
T20786 2266-2275 JJ denotes available
T20785 2261-2265 NNS denotes data
T20784 2257-2260 JJ denotes few
T20783 2253-2256 RB denotes yet
T20782 2250-2252 RB denotes as
T20781 2246-2249 VBP denotes are
T20780 2240-2245 EX denotes There
T20779 2238-2239 . denotes .
T20778 2237-2238 NNP denotes ]
T20777 2229-2237 CD denotes 12,28,29
T20776 2228-2229 NNP denotes [
T20775 2222-2227 NN denotes vitro
T20774 2219-2221 IN denotes in
T20773 2216-2218 NN denotes E2
T20772 2202-2215 NN denotes prostaglandin
T20771 2199-2201 IN denotes as
T20770 2194-2198 RB denotes well
T20769 2191-2193 RB denotes as
T20768 2189-2190 CD denotes 6
T20767 2184-2188 NN denotes gene
T20766 2166-2183 JJ denotes factor-stimulated
T20765 2157-2165 NN denotes necrosis
T20764 2151-2156 NN denotes tumor
T20763 2147-2150 CC denotes and
T20762 2142-2146 NNP denotes IL-8
T20761 2140-2141 , denotes ,
T20760 2136-2140 NNP denotes IL-6
T20759 2133-2135 IN denotes as
T20758 2128-2132 JJ denotes such
T20757 2118-2127 NNS denotes cytokines
T20756 2110-2117 JJ denotes several
T20755 2102-2109 VB denotes secrete
T20754 2099-2101 TO denotes to
T20753 2086-2098 NNS denotes synoviocytes
T20752 2075-2085 JJ denotes rheumatoid
T20751 2064-2074 VBZ denotes stimulates
T20750 2058-2063 NNP denotes IL-17
T20749 2056-2057 , denotes ,
T20748 2049-2056 NN denotes example
T20747 2045-2048 IN denotes For
T20746 2043-2044 . denotes .
T20745 2037-2043 NNS denotes joints
T20744 2033-2036 DT denotes the
T20743 2030-2032 IN denotes in
T20742 2024-2029 NNS denotes cells
T20741 2018-2023 JJ denotes other
T20740 2009-2017 VBP denotes activate
T20739 2004-2008 RB denotes also
T20738 1998-2003 WDT denotes which
T20737 1996-1997 , denotes ,
T20736 1986-1996 NNS denotes chemokines
T20735 1982-1985 CC denotes and
T20734 1972-1981 NNS denotes cytokines
T20733 1956-1971 JJ denotes proinflammatory
T20732 1953-1955 IN denotes of
T20731 1945-1952 NN denotes variety
T20730 1943-1944 DT denotes a
T20729 1935-1942 VB denotes produce
T20728 1929-1934 MD denotes might
T20727 1922-1928 NNS denotes joints
T20726 1919-1921 NNP denotes RA
T20725 1910-1918 JJ denotes inflamed
T20724 1907-1909 IN denotes in
T20723 1901-1906 NNS denotes cells
T20722 1893-1900 IN denotes between
T20721 1881-1892 NN denotes interaction
T20720 1873-1880 JJ denotes complex
T20719 1871-1872 DT denotes A
T20718 1869-1870 . denotes .
T20717 1868-1869 NNP denotes ]
T20716 1866-1868 CD denotes 27
T20715 1865-1866 NNP denotes [
T20714 1859-1864 NN denotes model
T20713 1849-1858 NN denotes arthritis
T20712 1832-1848 JJ denotes collagen-induced
T20711 1830-1831 DT denotes a
T20710 1827-1829 IN denotes in
T20709 1818-1826 NN denotes collagen
T20708 1815-1817 NNP denotes II
T20707 1810-1814 NN denotes type
T20706 1798-1809 VBG denotes recognizing
T20705 1792-1797 NNS denotes cells
T20704 1790-1791 NNP denotes T
T20703 1787-1789 IN denotes by
T20702 1777-1786 VBN denotes augmented
T20655 1538-1543 NNS denotes cells
T20654 1536-1537 NNP denotes T
T20653 1534-1535 CD denotes +
T20652 1531-1534 NNP denotes CD4
T20651 1521-1530 VBN denotes activated
T20650 1518-1520 IN denotes by
T20649 1511-1517 RB denotes mainly
T20648 1502-1510 VBN denotes produced
T20647 1499-1501 VBZ denotes is
T20646 1493-1498 NNP denotes IL-17
T20645 1491-1492 . denotes .
T20644 1478-1491 NN denotes proliferation
T20643 1469-1477 JJ denotes cellular
T20642 1466-1468 TO denotes to
T20641 1461-1465 IN denotes than
T20640 1454-1460 RB denotes rather
T20639 1445-1453 NN denotes activity
T20638 1436-1444 JJ denotes cellular
T20637 1426-1435 VBN denotes increased
T20636 1423-1425 TO denotes to
T20635 1419-1422 JJ denotes due
T20634 1416-1418 VB denotes be
T20633 1410-1415 MD denotes might
T20632 1404-1409 NNP denotes IL-17
T20631 1401-1403 IN denotes of
T20630 1388-1400 NN denotes upregulation
T20629 1383-1387 DT denotes this
T20628 1378-1382 IN denotes that
T20627 1376-1377 , denotes ,
T20626 1375-1376 -RRB- denotes )
T20625 1370-1375 VBN denotes shown
T20624 1366-1369 RB denotes not
T20623 1361-1365 NNS denotes data
T20622 1360-1361 -LRB- denotes (
T20621 1354-1359 NN denotes assay
T20620 1340-1353 NN denotes proliferation
T20619 1335-1339 NN denotes cell
T20618 1333-1334 DT denotes a
T20617 1330-1332 IN denotes by
T20616 1328-1329 , denotes ,
T20615 1323-1328 VBD denotes found
T20614 1320-1322 PRP denotes We
T20613 1318-1319 . denotes .
T20612 1312-1318 NN denotes manner
T20611 1297-1311 JJ denotes dose-dependent
T20610 1295-1296 DT denotes a
T20609 1292-1294 IN denotes in
T20608 1287-1291 NNP denotes PBMC
T20607 1284-1286 NNP denotes RA
T20928 3063-3073 NN denotes production
T20927 3057-3062 NN denotes IL-17
T20926 3051-3056 NN denotes vitro
T20925 3048-3050 IN denotes in
T20924 3038-3047 VBD denotes triggered
T20923 3032-3037 NNP denotes IL-15
T20922 3027-3031 WDT denotes that
T20921 3020-3026 NN denotes report
T20920 3013-3019 JJ denotes recent
T20919 3011-3012 DT denotes a
T20918 3006-3010 IN denotes with
T20606 1279-1283 IN denotes from
T20605 1268-1278 NN denotes production
T20604 1262-1267 NNP denotes IL-17
T20603 1252-1261 VBD denotes increased
T20602 1250-1251 , denotes ,
T20601 1242-1250 NN denotes receptor
T20600 1237-1241 NN denotes cell
T20599 1235-1236 NNP denotes T
T20598 1231-1234 DT denotes the
T20597 1223-1230 IN denotes through
T20596 1213-1222 VBG denotes signaling
T20595 1209-1212 IN denotes for
T20594 1199-1208 NN denotes anti-CD28
T20593 1198-1199 NN denotes /
T20592 1190-1198 JJ denotes anti-CD3
T20591 1187-1189 IN denotes as
T20590 1182-1186 RB denotes well
T20589 1179-1181 RB denotes as
T20588 1177-1178 , denotes ,
T20587 1169-1177 NNS denotes mitogens
T20586 1166-1168 IN denotes as
T20585 1162-1165 NNP denotes PHA
T20584 1160-1161 , denotes ,
T20583 1149-1160 NNS denotes experiments
T20582 1145-1148 PRP$ denotes our
T20581 1142-1144 IN denotes In
T20580 1140-1141 . denotes .
T20579 1139-1140 NNP denotes ]
T20578 1137-1139 CD denotes 25
T20577 1136-1137 NNP denotes [
T20576 1124-1135 NNS denotes individuals
T20575 1116-1123 JJ denotes healthy
T20574 1113-1115 IN denotes in
T20573 1101-1112 NN denotes stimulation
T20572 1091-1100 JJ denotes anti-CD28
T20571 1090-1091 NN denotes /
T20570 1082-1090 JJ denotes anti-CD3
T20569 1079-1081 IN denotes by
T20568 1070-1078 VBN denotes achieved
T20567 1067-1069 VB denotes be
T20566 1063-1066 MD denotes can
T20565 1052-1062 NN denotes production
T20564 1046-1051 JJ denotes IL-17
T20563 1043-1045 IN denotes of
T20562 1037-1042 NN denotes level
T20561 1029-1036 JJS denotes highest
T20560 1025-1028 DT denotes the
T20559 1016-1024 IN denotes although
T20558 1014-1015 , denotes ,
T20557 1012-1014 NNP denotes RA
T20556 1009-1011 IN denotes in
T20555 998-1008 NN denotes production
T20554 992-997 JJ denotes IL-17
T20553 982-991 VBP denotes stimulate
T20552 977-981 WDT denotes that
T20551 970-976 NNS denotes agents
T20550 966-969 DT denotes the
T20549 963-965 IN denotes on
T20548 953-962 JJ denotes available
T20547 948-952 NNS denotes data
T20546 944-947 JJ denotes few
T20545 940-943 VBP denotes are
T20544 934-939 EX denotes there
T20543 932-933 , denotes ,
T20542 925-932 RB denotes However
T20541 923-924 . denotes .
T20540 922-923 NNP denotes ]
T20539 920-922 CD denotes 15
T20538 919-920 NNP denotes [
T20537 913-918 NN denotes fluid
T20536 904-912 JJ denotes synovial
T20535 901-903 NNP denotes OA
T20534 898-900 IN denotes in
T20533 893-897 IN denotes than
T20532 887-892 NN denotes fluid
T20531 878-886 JJ denotes synovial
T20530 875-877 NNP denotes RA
T20529 872-874 IN denotes in
T20528 865-871 JJR denotes higher
T20527 862-864 VB denotes be
T20526 859-861 TO denotes to
T20525 853-858 VBN denotes found
T20524 848-852 VBD denotes were
T20523 842-847 NNP denotes IL-17
T20522 839-841 IN denotes of
T20521 832-838 NNS denotes Levels
T20520 830-831 . denotes .
T20519 826-830 VBD denotes used
T20518 823-825 PRP denotes it
T20517 815-822 NN denotes pathway
T20516 805-814 VBG denotes signaling
T20515 799-804 WDT denotes which
T20514 795-798 CC denotes and
T20513 793-794 , denotes ,
T20512 789-793 NNP denotes PBMC
T20511 786-788 NNP denotes RA
T20510 783-785 IN denotes in
T20509 773-782 VBN denotes regulated
T20508 770-772 VBZ denotes is
T20507 759-769 NN denotes production
T20506 753-758 JJ denotes IL-17
T20505 749-752 WRB denotes how
T20504 740-748 VB denotes evaluate
T20503 737-739 TO denotes to
T20502 731-736 VBD denotes tried
T20501 728-730 PRP denotes we
T20500 726-727 , denotes ,
T20499 719-726 NNS denotes studies
T20498 715-718 PRP$ denotes our
T20497 712-714 IN denotes In
T20496 710-711 . denotes .
T20495 700-710 NNS denotes properties
T20494 684-699 JJ denotes proinflammatory
T20493 679-683 IN denotes with
T20492 670-678 NN denotes cytokine
T20491 657-669 JJ denotes cell-derived
T20490 655-656 NNP denotes T
T20489 653-654 DT denotes a
T20488 650-652 IN denotes as
T20487 640-649 VBN denotes described
T20486 635-639 VBN denotes been
T20485 631-634 VBZ denotes has
T20484 628-630 PRP denotes it
T20483 620-627 IN denotes because
T20482 610-619 VBG denotes appealing
T20481 607-609 VBZ denotes is
T20480 601-606 NNP denotes IL-17
T20479 599-600 , denotes ,
T20478 592-599 NN denotes respect
T20477 587-591 DT denotes this
T20476 584-586 IN denotes In
T20475 582-583 . denotes .
T20474 572-582 NN denotes importance
T20473 568-571 PRP$ denotes its
T20472 560-567 VBN denotes limited
T20471 556-559 VBZ denotes has
T20470 546-555 NNS denotes cytokines
T20469 533-545 JJ denotes cell-derived
T20468 531-532 NNP denotes T
T20467 528-530 IN denotes of
T20466 523-527 NN denotes lack
T20465 519-522 DT denotes the
T20464 517-518 , denotes ,
T20463 505-517 NN denotes inflammation
T20462 496-504 JJ denotes synovial
T20461 485-495 JJ denotes rheumatoid
T20460 482-484 IN denotes of
T20459 469-481 NN denotes augmentation
T20458 465-468 DT denotes the
T20457 462-464 IN denotes in
T20456 457-461 NN denotes role
T20455 455-456 DT denotes a
T20454 450-454 VB denotes have
T20453 446-449 MD denotes may
T20452 440-445 NNS denotes cells
T20451 438-439 NNP denotes T
T20450 429-437 IN denotes Although
T20449 427-428 . denotes .
T20448 426-427 NNP denotes ]
T20447 424-426 CD denotes 24
T20446 423-424 NNP denotes [
T20445 414-422 NN denotes synovium
T20444 411-413 NNP denotes RA
T20443 408-410 IN denotes in
T20442 401-407 VB denotes detect
T20441 398-400 TO denotes to
T20440 388-397 JJ denotes difficult
T20701 1763-1776 RB denotes significantly
T20700 1759-1762 VBD denotes was
T20699 1748-1758 NN denotes production
T20698 1742-1747 JJ denotes IL-17
T20697 1740-1741 , denotes ,
T20696 1732-1740 NN denotes addition
T20695 1729-1731 IN denotes In
T20694 1727-1728 . denotes .
T20693 1726-1727 NNP denotes ]
T20692 1724-1726 CD denotes 14
T20691 1723-1724 NNP denotes [
T20690 1713-1722 NN denotes infection
T20689 1703-1712 JJ denotes pulmonary
T20688 1689-1702 JJ denotes Gram-negative
T20687 1686-1688 IN denotes in
T20686 1676-1685 NN denotes mechanism
T20685 1665-1675 VBG denotes triggering
T20684 1659-1664 JJ denotes IL-23
T20683 1656-1658 DT denotes an
T20682 1652-1655 IN denotes via
T20681 1646-1651 NNS denotes cells
T20680 1644-1645 NNP denotes T
T20679 1642-1643 CD denotes +
T20678 1639-1642 CD denotes CD8
T20677 1636-1638 IN denotes by
T20676 1627-1635 VBN denotes produced
T20675 1624-1626 VB denotes be
T20674 1619-1623 RB denotes also
T20673 1615-1618 MD denotes can
T20672 1612-1614 PRP denotes it
T20671 1610-1611 , denotes ,
T20670 1603-1610 RB denotes However
T20669 1601-1602 . denotes .
T20668 1600-1601 NNP denotes ]
T20667 1598-1600 CD denotes 26
T20666 1597-1598 NNP denotes [
T20665 1587-1596 NN denotes phenotype
T20664 1583-1586 JJ denotes Th2
T20663 1579-1582 DT denotes the
T20662 1575-1578 RB denotes not
T20661 1573-1574 , denotes ,
T20660 1568-1573 NNS denotes cells
T20659 1560-1567 JJ denotes Th1/Th0
T20658 1556-1559 IN denotes for
T20657 1545-1555 RB denotes especially
T20656 1543-1544 , denotes ,
T20439 381-387 VBN denotes proved
T20438 375-380 RB denotes often
T20437 370-374 VBP denotes have
T20436 368-369 , denotes ,
T20435 356-368 NN denotes interferon-γ
T20434 352-355 CC denotes and
T20433 347-351 NN denotes IL-4
T20432 336-346 RB denotes especially
T20431 334-335 , denotes ,
T20430 325-334 NNS denotes cytokines
T20429 312-324 JJ denotes cell-derived
T20428 310-311 NNP denotes T
T20427 306-309 DT denotes the
T20426 298-305 IN denotes whereas
T20425 296-297 , denotes ,
T20424 288-296 NN denotes synovium
T20423 277-287 JJ denotes rheumatoid
T20422 274-276 IN denotes in
T20421 265-273 JJ denotes abundant
T20420 261-264 VBP denotes are
T20419 255-260 NN denotes TNF-α
T20418 251-254 CC denotes and
T20417 246-250 NN denotes IL-1
T20416 243-245 IN denotes as
T20415 238-242 JJ denotes such
T20414 228-237 NNS denotes cytokines
T20413 212-227 JJ denotes Proinflammatory
T20412 210-211 . denotes .
T20411 209-210 NNP denotes ]
T20410 207-209 CD denotes 23
T20409 206-207 NNP denotes [
T20408 200-205 NNS denotes cells
T20407 188-199 NN denotes mononuclear
T20406 185-187 IN denotes by
T20405 172-184 NN denotes infiltration
T20404 164-171 JJ denotes intense
T20403 161-163 DT denotes an
T20402 157-160 CC denotes and
T20401 151-156 NNS denotes cells
T20400 144-150 NN denotes lining
T20399 135-143 JJ denotes synovial
T20398 132-134 IN denotes of
T20397 120-131 NN denotes hyperplasia
T20396 117-119 IN denotes by
T20395 103-116 VBN denotes characterized
T20394 100-102 VBZ denotes is
T20393 97-99 NNP denotes RA
T20392 95-96 . denotes .
T20391 94-95 NNP denotes ]
T20390 90-94 CD denotes 5,22
T20389 89-90 NNP denotes [
T20388 78-88 NNS denotes properties
T20387 62-77 JJ denotes proinflammatory
T20386 57-61 IN denotes with
T20385 49-56 NN denotes product
T20384 44-48 NN denotes cell
T20383 42-43 NNP denotes T
T20382 40-41 DT denotes a
T20381 37-39 IN denotes as
T20380 27-36 VBN denotes described
T20379 21-26 JJ denotes first
T20378 17-20 VBD denotes was
T20377 11-16 NNP denotes IL-17
T21144 4313-4322 NN denotes mechanism
T21143 4311-4312 DT denotes a
T21142 4308-4310 IN denotes by
T21141 4302-4307 NN denotes NF-κB
T21140 4292-4301 VB denotes stimulate
T21145 4323-4332 VBG denotes involving
T21151 4378-4380 CD denotes 33
T21150 4377-4378 NNP denotes [
T21149 4369-4376 NN denotes protein
T21148 4351-4368 JJ denotes p300/CREB-binding
T21147 4341-4350 NN denotes acetylase
T21146 4333-4340 NN denotes histone
T21241 4873-4876 NNP denotes Akt
T21240 4868-4872 IN denotes that
T21239 4863-4867 NN denotes fact
T21238 4859-4862 DT denotes The
T21237 4857-4858 . denotes .
R10760 T20377 T20380 nsubjpass IL-17,described
R10761 T20378 T20380 auxpass was,described
R10762 T20379 T20380 advmod first,described
R10763 T20380 T20380 ROOT described,described
R10764 T20381 T20380 prep as,described
R10765 T20382 T20385 det a,product
R10766 T20383 T20385 compound T,product
R10767 T20384 T20385 compound cell,product
R10768 T20385 T20381 pobj product,as
R10769 T20386 T20385 prep with,product
R10770 T20387 T20388 amod proinflammatory,properties
R10771 T20388 T20386 pobj properties,with
R10772 T20389 T20391 compound [,]
R10773 T20390 T20391 compound "5,22",]
R10774 T20391 T20388 appos ],properties
R10775 T20392 T20380 punct .,described
R10776 T20393 T20395 nsubjpass RA,characterized
R10777 T20394 T20395 auxpass is,characterized
R10778 T20395 T20395 ROOT characterized,characterized
R10779 T20396 T20395 agent by,characterized
R10780 T20397 T20396 pobj hyperplasia,by
R10781 T20398 T20397 prep of,hyperplasia
R10782 T20399 T20401 amod synovial,cells
R10783 T20400 T20401 compound lining,cells
R10784 T20401 T20398 pobj cells,of
R10785 T20402 T20397 cc and,hyperplasia
R10786 T20403 T20405 det an,infiltration
R10787 T20404 T20405 amod intense,infiltration
R10788 T20405 T20397 conj infiltration,hyperplasia
R10789 T20406 T20405 prep by,infiltration
R10790 T20407 T20408 compound mononuclear,cells
R10791 T20408 T20406 pobj cells,by
R10792 T20409 T20411 nmod [,]
R10793 T20410 T20411 nummod 23,]
R10794 T20411 T20408 appos ],cells
R10795 T20412 T20395 punct .,characterized
R10796 T20413 T20414 amod Proinflammatory,cytokines
R10797 T20414 T20420 nsubj cytokines,are
R10798 T20415 T20416 amod such,as
R10799 T20416 T20414 prep as,cytokines
R10800 T20417 T20416 pobj IL-1,as
R10829 T20446 T20443 pobj [,in
R10830 T20447 T20448 nummod 24,]
R10831 T20448 T20446 appos ],[
R10832 T20449 T20420 punct .,are
R10833 T20450 T20454 mark Although,have
R10834 T20451 T20452 compound T,cells
R10835 T20452 T20454 nsubj cells,have
R10836 T20453 T20454 aux may,have
R10837 T20454 T20472 advcl have,limited
R10838 T20455 T20456 det a,role
R10839 T20456 T20454 dobj role,have
R10840 T20457 T20456 prep in,role
R10841 T20458 T20459 det the,augmentation
R10842 T20459 T20457 pobj augmentation,in
R10843 T20460 T20459 prep of,augmentation
R10844 T20461 T20463 amod rheumatoid,inflammation
R10845 T20462 T20463 amod synovial,inflammation
R10846 T20463 T20460 pobj inflammation,of
R10847 T20464 T20459 punct ",",augmentation
R10848 T20465 T20466 det the,lack
R10849 T20466 T20472 nsubj lack,limited
R10850 T20467 T20466 prep of,lack
R10851 T20468 T20470 nmod T,cytokines
R10852 T20469 T20470 amod cell-derived,cytokines
R10868 T20485 T20487 aux has,described
R10869 T20486 T20487 auxpass been,described
R10870 T20487 T20482 advcl described,appealing
R10871 T20488 T20487 prep as,described
R10872 T20489 T20492 det a,cytokine
R10873 T20490 T20492 nmod T,cytokine
R10874 T20491 T20492 amod cell-derived,cytokine
R10875 T20492 T20488 pobj cytokine,as
R10876 T20493 T20492 prep with,cytokine
R10877 T20494 T20495 amod proinflammatory,properties
R10878 T20495 T20493 pobj properties,with
R10879 T20496 T20482 punct .,appealing
R10880 T20497 T20502 prep In,tried
R10881 T20498 T20499 poss our,studies
R10882 T20499 T20497 pobj studies,In
R10883 T20500 T20502 punct ",",tried
R10884 T20501 T20502 nsubj we,tried
R10885 T20502 T20502 ROOT tried,tried
R10886 T20503 T20504 aux to,evaluate
R10887 T20504 T20502 xcomp evaluate,tried
R10888 T20505 T20509 advmod how,regulated
R10889 T20506 T20507 amod IL-17,production
R10890 T20507 T20509 nsubjpass production,regulated
R10891 T20508 T20509 auxpass is,regulated
R10892 T20509 T20504 ccomp regulated,evaluate
R10893 T20510 T20509 prep in,regulated
R10894 T20511 T20512 compound RA,PBMC
R10895 T20512 T20510 pobj PBMC,in
R10896 T20513 T20509 punct ",",regulated
R10897 T20514 T20509 cc and,regulated
R10898 T20515 T20516 det which,signaling
R10899 T20516 T20502 advcl signaling,tried
R10900 T20517 T20516 dobj pathway,signaling
R10901 T20518 T20519 nsubj it,used
R10902 T20519 T20517 relcl used,pathway
R10903 T20520 T20502 punct .,tried
R10904 T20521 T20525 nsubjpass Levels,found
R10905 T20522 T20521 prep of,Levels
R10906 T20523 T20522 pobj IL-17,of
R10907 T20524 T20525 auxpass were,found
R10908 T20525 T20525 ROOT found,found
R10909 T20526 T20527 aux to,be
R10910 T20527 T20525 xcomp be,found
R10911 T20528 T20527 acomp higher,be
R10912 T20529 T20527 prep in,be
R10913 T20530 T20532 nmod RA,fluid
R10914 T20531 T20532 compound synovial,fluid
R10915 T20532 T20529 pobj fluid,in
R10916 T20558 T20545 punct ",",are
R10917 T20533 T20525 prep than,found
R10918 T20559 T20568 mark although,achieved
R10919 T20534 T20533 prep in,than
R10920 T20560 T20562 det the,level
R10921 T20561 T20562 amod highest,level
R10922 T20562 T20568 nsubjpass level,achieved
R10923 T20563 T20562 prep of,level
R10924 T20564 T20565 compound IL-17,production
R10925 T20565 T20563 pobj production,of
R10926 T20535 T20534 pobj OA,in
R10927 T20566 T20568 aux can,achieved
R10928 T20567 T20568 auxpass be,achieved
R10929 T20568 T20545 advcl achieved,are
R10930 T20536 T20537 compound synovial,fluid
R10931 T20569 T20568 agent by,achieved
R10932 T20570 T20573 amod anti-CD3,stimulation
R10933 T20571 T20573 nmod /,stimulation
R10934 T20572 T20573 amod anti-CD28,stimulation
R10935 T20537 T20540 det fluid,]
R10936 T20573 T20569 pobj stimulation,by
R10937 T20574 T20568 prep in,achieved
R10938 T20575 T20576 amod healthy,individuals
R10939 T20538 T20540 nmod [,]
R10940 T20576 T20574 pobj individuals,in
R10941 T20577 T20579 nmod [,]
R10942 T20578 T20579 nummod 25,]
R10943 T20539 T20540 nummod 15,]
R10944 T20579 T20576 appos ],individuals
R10945 T20580 T20545 punct .,are
R10946 T20581 T20603 prep In,increased
R10947 T20540 T20540 ROOT ],]
R10948 T20582 T20583 poss our,experiments
R10949 T20583 T20581 pobj experiments,In
R10950 T20541 T20525 punct .,found
R10951 T20584 T20603 punct ",",increased
R10952 T20585 T20603 nsubj PHA,increased
R10953 T20586 T20585 prep as,PHA
R10954 T20542 T20545 advmod However,are
R10955 T20587 T20586 pobj mitogens,as
R10956 T20588 T20587 punct ",",mitogens
R10957 T20589 T20591 advmod as,as
R10958 T20543 T20545 punct ",",are
R10959 T20590 T20591 advmod well,as
R10960 T20591 T20587 cc as,mitogens
R10961 T20592 T20594 amod anti-CD3,anti-CD28
R10962 T20544 T20545 expl there,are
R10963 T20593 T20594 compound /,anti-CD28
R10964 T20594 T20587 conj anti-CD28,mitogens
R10965 T20595 T20587 prep for,mitogens
R10966 T20545 T20545 ROOT are,are
R10967 T20596 T20595 pcomp signaling,for
R10968 T20597 T20596 prep through,signaling
R10969 T20546 T20547 amod few,data
R10970 T20598 T20601 det the,receptor
R10971 T20599 T20601 compound T,receptor
R10972 T20600 T20601 compound cell,receptor
R10973 T20601 T20597 pobj receptor,through
R10974 T20602 T20603 punct ",",increased
R10975 T20603 T20603 ROOT increased,increased
R10976 T20604 T20605 compound IL-17,production
R10977 T20605 T20603 dobj production,increased
R10978 T20547 T20545 attr data,are
R10979 T20606 T20605 prep from,production
R10980 T20607 T20608 compound RA,PBMC
R10981 T20608 T20606 pobj PBMC,from
R10982 T20548 T20547 amod available,data
R10983 T20609 T20603 prep in,increased
R10984 T20610 T20612 det a,manner
R10985 T20611 T20612 amod dose-dependent,manner
R10986 T20549 T20547 prep on,data
R10987 T20612 T20609 pobj manner,in
R10988 T20550 T20551 det the,agents
R10989 T20613 T20603 punct .,increased
R10990 T20551 T20549 pobj agents,on
R10991 T20614 T20615 nsubj We,found
R10992 T20615 T20615 ROOT found,found
R10993 T20552 T20553 nsubj that,stimulate
R10994 T20616 T20615 punct ",",found
R10995 T20617 T20615 prep by,found
R10996 T20618 T20621 det a,assay
R10997 T20553 T20551 relcl stimulate,agents
R10998 T20619 T20620 compound cell,proliferation
R10999 T20620 T20621 compound proliferation,assay
R11000 T20554 T20555 amod IL-17,production
R11001 T20621 T20617 pobj assay,by
R11002 T20622 T20623 punct (,data
R11003 T20555 T20553 dobj production,stimulate
R11004 T20623 T20615 advcl data,found
R11005 T20624 T20625 neg not,shown
R11006 T20556 T20555 prep in,production
R11007 T20625 T20623 acl shown,data
R11008 T20626 T20623 punct ),data
R11009 T20557 T20556 pobj RA,in
R11010 T20627 T20634 punct ",",be
R11011 T20628 T20634 mark that,be
R11012 T20629 T20630 det this,upregulation
R11013 T20655 T20650 pobj cells,by
R11014 T20630 T20634 nsubj upregulation,be
R11015 T20631 T20630 prep of,upregulation
R11016 T20632 T20631 pobj IL-17,of
R11017 T20633 T20634 aux might,be
R11018 T20656 T20655 punct ",",cells
R11019 T20634 T20623 ccomp be,data
R11020 T20635 T20634 acomp due,be
R11021 T20636 T20635 pcomp to,due
R11022 T20637 T20639 amod increased,activity
R11023 T20638 T20639 amod cellular,activity
R11024 T20639 T20636 pobj activity,to
R11025 T20657 T20658 advmod especially,for
R11026 T20640 T20641 advmod rather,than
R11027 T20641 T20634 cc than,be
R11028 T20642 T20641 prep to,than
R11029 T20643 T20644 amod cellular,proliferation
R11030 T20658 T20650 prep for,by
R11031 T20644 T20642 pobj proliferation,to
R11032 T20645 T20615 punct .,found
R11033 T20646 T20648 nsubjpass IL-17,produced
R11034 T20659 T20660 amod Th1/Th0,cells
R11035 T20647 T20648 auxpass is,produced
R11036 T20648 T20648 ROOT produced,produced
R11037 T20649 T20650 advmod mainly,by
R11038 T20660 T20658 pobj cells,for
R11039 T20650 T20648 agent by,produced
R11040 T20651 T20655 amod activated,cells
R11041 T20661 T20658 punct ",",for
R11042 T20652 T20655 compound CD4,cells
R11043 T20653 T20655 nummod +,cells
R11044 T20654 T20655 compound T,cells
R11045 T20662 T20650 neg not,by
R11046 T20663 T20665 det the,phenotype
R11047 T20664 T20665 amod Th2,phenotype
R11048 T20665 T20648 npadvmod phenotype,produced
R11049 T20752 T20753 compound rheumatoid,synoviocytes
R11050 T20666 T20665 appos [,phenotype
R11051 T20753 T20751 dobj synoviocytes,stimulates
R11052 T20754 T20755 aux to,secrete
R11053 T20667 T20668 nummod 26,]
R11054 T20755 T20751 xcomp secrete,stimulates
R11055 T20756 T20757 amod several,cytokines
R11056 T20757 T20755 dobj cytokines,secrete
R11057 T20668 T20665 conj ],phenotype
R11058 T20758 T20759 amod such,as
R11059 T20759 T20757 prep as,cytokines
R11060 T20669 T20648 punct .,produced
R11061 T20760 T20759 pobj IL-6,as
R11062 T20761 T20760 punct ",",IL-6
R11063 T20762 T20760 conj IL-8,IL-6
R11064 T20670 T20676 advmod However,produced
R11065 T20763 T20762 cc and,IL-8
R11066 T20764 T20765 compound tumor,necrosis
R11067 T20671 T20676 punct ",",produced
R11068 T20765 T20767 compound necrosis,gene
R11069 T20766 T20767 compound factor-stimulated,gene
R11070 T20767 T20755 npadvmod gene,secrete
R11071 T20768 T20767 nummod 6,gene
R11072 T20672 T20676 nsubjpass it,produced
R11073 T20769 T20771 advmod as,as
R11074 T20673 T20676 aux can,produced
R11075 T20770 T20771 advmod well,as
R11076 T20771 T20767 cc as,gene
R11077 T20772 T20773 compound prostaglandin,E2
R11078 T20674 T20676 advmod also,produced
R11079 T20773 T20767 conj E2,gene
R11080 T20774 T20755 prep in,secrete
R11081 T20775 T20778 amod vitro,]
R11082 T20675 T20676 auxpass be,produced
R11083 T20776 T20778 compound [,]
R11084 T20777 T20778 compound "12,28,29",]
R11085 T20676 T20676 ROOT produced,produced
R11086 T20778 T20774 pobj ],in
R11087 T20779 T20751 punct .,stimulates
R11088 T20677 T20676 agent by,produced
R11089 T20780 T20781 expl There,are
R11090 T20781 T20781 ROOT are,are
R11091 T20782 T20784 advmod as,few
R11092 T20678 T20681 nummod CD8,cells
R11093 T20783 T20784 advmod yet,few
R11094 T20784 T20785 nummod few,data
R11095 T20679 T20681 nummod +,cells
R11096 T20785 T20781 attr data,are
R11097 T20786 T20785 amod available,data
R11098 T20787 T20786 prep on,available
R11099 T20680 T20681 compound T,cells
R11100 T20788 T20789 det the,agents
R11101 T20789 T20787 pobj agents,on
R11102 T20790 T20791 nsubj that,stimulate
R11103 T20681 T20677 pobj cells,by
R11104 T20791 T20789 relcl stimulate,agents
R11105 T20792 T20793 amod IL-17,production
R11106 T20793 T20791 dobj production,stimulate
R11107 T20682 T20676 prep via,produced
R11108 T20794 T20793 prep in,production
R11109 T20795 T20794 pobj RA,in
R11110 T20683 T20686 det an,mechanism
R11111 T20796 T20781 punct ",",are
R11112 T20797 T20807 mark although,known
R11113 T20684 T20686 amod IL-23,mechanism
R11114 T20798 T20799 det some,cytokines
R11115 T20799 T20807 nsubjpass cytokines,known
R11116 T20685 T20686 amod triggering,mechanism
R11117 T20800 T20801 punct (,IL-15
R11118 T20801 T20799 appos IL-15,cytokines
R11119 T20802 T20801 cc and,IL-15
R11120 T20686 T20682 pobj mechanism,via
R11121 T20803 T20801 conj IL-23,IL-15
R11122 T20804 T20799 punct ),cytokines
R11123 T20805 T20807 aux have,known
R11124 T20806 T20807 auxpass been,known
R11125 T20807 T20781 advcl known,are
R11126 T20808 T20809 aux to,regulate
R11127 T20809 T20807 xcomp regulate,known
R11128 T20810 T20811 compound IL-17,production
R11129 T20687 T20686 prep in,mechanism
R11130 T20811 T20809 dobj production,regulate
R11131 T20812 T20814 nmod [,]
R11132 T20813 T20814 nummod "13,14",]
R11133 T20688 T20690 amod Gram-negative,infection
R11134 T20814 T20781 attr ],are
R11135 T20815 T20781 punct .,are
R11136 T20816 T20818 nsubj We,investigated
R11137 T20689 T20690 amod pulmonary,infection
R11138 T20817 T20818 advmod therefore,investigated
R11139 T20818 T20818 ROOT investigated,investigated
R11140 T20819 T20828 det the,responding
R11141 T20690 T20687 pobj infection,in
R11142 T20820 T20828 prep in,responding
R11143 T20821 T20822 amod vitro,production
R11144 T20822 T20820 pobj production,in
R11145 T20691 T20693 nmod [,]
R11146 T20823 T20822 prep of,production
R11147 T20824 T20823 pobj IL-17,of
R11148 T20825 T20822 prep in,production
R11149 T20692 T20693 nummod 14,]
R11150 T20826 T20827 compound RA,PBMC
R11151 T20827 T20825 pobj PBMC,in
R11152 T20828 T20818 dobj responding,investigated
R11153 T20693 T20686 appos ],mechanism
R11154 T20829 T20828 prep to,responding
R11155 T20830 T20831 det a,variety
R11156 T20831 T20829 pobj variety,to
R11157 T20694 T20676 punct .,produced
R11158 T20832 T20831 prep of,variety
R11159 T20833 T20832 pobj cytokines/chemokines,of
R11160 T20834 T20833 cc and,cytokines/chemokines
R11161 T20695 T20702 prep In,augmented
R11162 T20835 T20833 conj mitogens,cytokines/chemokines
R11163 T20836 T20838 advmod as,as
R11164 T20696 T20695 pobj addition,In
R11165 T20837 T20838 advmod well,as
R11166 T20838 T20833 cc as,cytokines/chemokines
R11167 T20839 T20841 compound T,receptor
R11168 T20697 T20702 punct ",",augmented
R11169 T20840 T20841 compound cell,receptor
R11170 T20841 T20845 nsubj receptor,ligation
R11171 T20842 T20843 punct (,TCR
R11172 T20843 T20841 appos TCR,receptor
R11173 T20844 T20841 punct ),receptor
R11174 T20845 T20818 ccomp ligation,investigated
R11175 T20846 T20818 advcl using,investigated
R11176 T20698 T20699 compound IL-17,production
R11177 T20847 T20849 amod anti-CD3,anti-CD28
R11178 T20699 T20702 nsubjpass production,augmented
R11179 T20848 T20849 compound /,anti-CD28
R11180 T20700 T20702 auxpass was,augmented
R11181 T20701 T20702 advmod significantly,augmented
R11182 T20702 T20702 ROOT augmented,augmented
R11183 T20849 T20846 dobj anti-CD28,using
R11184 T20703 T20702 agent by,augmented
R11185 T20850 T20818 punct .,investigated
R11186 T20851 T20852 poss Our,studies
R11187 T20852 T20853 nsubj studies,demonstrated
R11188 T20704 T20705 compound T,cells
R11189 T20853 T20853 ROOT demonstrated,demonstrated
R11190 T20854 T20864 mark that,increased
R11191 T20855 T20862 nsubj IL-15,ligation
R11192 T20705 T20703 pobj cells,by
R11193 T20856 T20855 cc and,IL-15
R11194 T20857 T20855 conj MCP-1,IL-15
R11195 T20706 T20705 acl recognizing,cells
R11196 T20858 T20860 advmod as,as
R11197 T20859 T20860 advmod well,as
R11198 T20860 T20857 cc as,MCP-1
R11199 T20707 T20709 compound type,collagen
R11200 T20861 T20862 compound TCR,ligation
R11201 T20862 T20864 nsubj ligation,increased
R11202 T20863 T20864 advmod significantly,increased
R11203 T20708 T20709 compound II,collagen
R11204 T20864 T20853 ccomp increased,demonstrated
R11205 T20865 T20866 det the,production
R11206 T20866 T20864 dobj production,increased
R11207 T20709 T20706 dobj collagen,recognizing
R11208 T20867 T20866 prep of,production
R11209 T20868 T20867 pobj IL-17,of
R11210 T20869 T20864 prep in,increased
R11211 T20710 T20706 prep in,recognizing
R11212 T20870 T20871 compound RA,PBMC
R11213 T20871 T20869 pobj PBMC,in
R11214 T20872 T20853 punct .,demonstrated
R11215 T20711 T20714 det a,model
R11216 T20873 T20873 ROOT Adding,Adding
R11217 T20874 T20873 dobj IL-15,Adding
R11218 T20875 T20874 cc or,IL-15
R11219 T20712 T20714 amod collagen-induced,model
R11220 T20876 T20874 conj MCP-1,IL-15
R11221 T20877 T20873 prep to,Adding
R11222 T20878 T20879 compound TCR,ligation
R11223 T20879 T20880 dep ligation,augmented
R11224 T20880 T20873 nsubj augmented,Adding
R11225 T20881 T20882 amod IL-17,production
R11226 T20713 T20714 compound arthritis,model
R11227 T20882 T20880 dobj production,augmented
R11228 T20883 T20884 advmod more,markedly
R11229 T20884 T20880 advmod markedly,augmented
R11230 T20885 T20880 punct .,augmented
R11231 T20714 T20710 pobj model,in
R11232 T20886 T20910 prep In,affect
R11233 T20887 T20886 pobj contrast,In
R11234 T20888 T20910 punct ",",affect
R11235 T20715 T20717 nmod [,]
R11236 T20889 T20910 nsubj IL-1,affect
R11237 T20890 T20889 cc and,IL-1
R11238 T20891 T20889 conj TNF-α,IL-1
R11239 T20716 T20717 nummod 27,]
R11240 T20892 T20889 punct ",",IL-1
R11241 T20893 T20895 nsubjpass which,known
R11242 T20894 T20895 auxpass are,known
R11243 T20717 T20714 appos ],model
R11244 T20895 T20889 relcl known,IL-1
R11245 T20896 T20897 aux to,have
R11246 T20897 T20895 xcomp have,known
R11247 T20718 T20702 punct .,augmented
R11248 T20898 T20899 amod proinflammatory,properties
R11249 T20899 T20897 dobj properties,have
R11250 T20900 T20897 cc and,have
R11251 T20719 T20721 det A,interaction
R11252 T20901 T20903 aux to,increased
R11253 T20902 T20903 auxpass be,increased
R11254 T20903 T20895 xcomp increased,known
R11255 T20904 T20903 prep in,increased
R11256 T20720 T20721 amod complex,interaction
R11257 T20905 T20906 compound RA,joints
R11258 T20906 T20904 pobj joints,in
R11259 T20907 T20889 punct ",",IL-1
R11260 T20721 T20729 nsubj interaction,produce
R11261 T20908 T20910 aux did,affect
R11262 T20909 T20910 neg not,affect
R11263 T20722 T20721 prep between,interaction
R11264 T20910 T20910 ROOT affect,affect
R11265 T20911 T20912 amod IL-17,production
R11266 T20723 T20722 pobj cells,between
R11267 T20912 T20910 dobj production,affect
R11268 T20724 T20723 prep in,cells
R11269 T20913 T20910 punct .,affect
R11270 T20914 T20915 poss Our,data
R11271 T20725 T20727 amod inflamed,joints
R11272 T20915 T20916 nsubj data,were
R11273 T20916 T20916 ROOT were,were
R11274 T20917 T20916 acomp consistent,were
R11275 T20918 T20917 prep with,consistent
R11276 T20919 T20921 det a,report
R11277 T20920 T20921 amod recent,report
R11278 T20726 T20727 compound RA,joints
R11279 T20921 T20918 pobj report,with
R11280 T20922 T20924 dobj that,triggered
R11281 T20923 T20924 nsubj IL-15,triggered
R11282 T20727 T20724 pobj joints,in
R11283 T20924 T20921 acl triggered,report
R11284 T20925 T20924 prep in,triggered
R11285 T20926 T20928 amod vitro,production
R11286 T20728 T20729 aux might,produce
R11287 T20729 T20729 ROOT produce,produce
R11288 T20927 T20928 compound IL-17,production
R11289 T20928 T20925 pobj production,in
R11290 T20730 T20731 det a,variety
R11291 T20929 T20928 prep in,production
R11292 T20930 T20929 pobj PBMC,in
R11293 T20931 T20916 punct ",",were
R11294 T20731 T20729 dobj variety,produce
R11295 T20932 T20916 cc but,were
R11296 T20933 T20936 nsubj TNF-α,do
R11297 T20934 T20936 aux did,do
R11298 T20732 T20731 prep of,variety
R11299 T20935 T20936 neg not,do
R11300 T20936 T20916 conj do,were
R11301 T20937 T20938 advmod so,[
R11302 T20733 T20734 amod proinflammatory,cytokines
R11303 T20938 T20940 quantmod [,]
R11304 T20939 T20940 nummod 13,]
R11305 T20940 T20936 dobj ],do
R11306 T20734 T20732 pobj cytokines,of
R11307 T20941 T20916 punct .,were
R11308 T20942 T20944 mark Although,were
R11309 T20943 T20944 expl there,were
R11310 T20735 T20734 cc and,cytokines
R11311 T20944 T20957 advcl were,exert
R11312 T20945 T20946 det no,data
R11313 T20736 T20734 conj chemokines,cytokines
R11314 T20737 T20734 punct ",",cytokines
R11315 T20738 T20740 nsubj which,activate
R11316 T20739 T20740 advmod also,activate
R11317 T20946 T20944 attr data,were
R11318 T20947 T20950 mark that,induces
R11319 T20948 T20950 nsubj MCP-1,induces
R11320 T20740 T20734 relcl activate,cytokines
R11321 T20949 T20950 advmod directly,induces
R11322 T20950 T20957 advcl induces,exert
R11323 T20951 T20953 compound T,activation
R11324 T20952 T20953 compound cell,activation
R11325 T20953 T20950 dobj activation,induces
R11326 T20741 T20742 amod other,cells
R11327 T20954 T20957 punct ",",exert
R11328 T20955 T20957 nsubj it,exert
R11329 T20956 T20957 aux might,exert
R11330 T20742 T20740 dobj cells,activate
R11331 T20957 T20957 ROOT exert,exert
R11332 T20958 T20957 dobj effects,exert
R11333 T20743 T20740 prep in,activate
R11334 T20959 T20957 advmod indirectly,exert
R11335 T20960 T20957 prep on,exert
R11336 T20961 T20962 compound T,cells
R11337 T20744 T20745 det the,joints
R11338 T20962 T20960 pobj cells,on
R11339 T20963 T20957 prep through,exert
R11340 T20964 T20965 det the,activation
R11341 T20745 T20743 pobj joints,in
R11342 T20965 T20963 pobj activation,through
R11343 T20966 T20965 prep of,activation
R11344 T20967 T20966 pobj monocytes/macrophages,of
R11345 T20746 T20729 punct .,produce
R11346 T20968 T20967 prep in,monocytes/macrophages
R11347 T20969 T20970 compound PBMC,cultures
R11348 T20970 T20968 pobj cultures,in
R11349 T20747 T20751 prep For,stimulates
R11350 T20971 T20957 punct .,exert
R11351 T20972 T20973 mark As,reported
R11352 T20973 T20989 advcl reported,increases
R11353 T20748 T20747 pobj example,For
R11354 T20974 T20973 prep for,reported
R11355 T20975 T20976 amod normal,individuals
R11356 T20976 T20974 pobj individuals,for
R11357 T20749 T20751 punct ",",stimulates
R11358 T20977 T20979 nmod [,]
R11359 T20978 T20979 nummod 25,]
R11360 T20979 T20989 nsubj ],increases
R11361 T20750 T20751 nsubj IL-17,stimulates
R11362 T20980 T20979 punct ",",]
R11363 T20981 T20983 compound T,activation
R11364 T20982 T20983 compound cell,activation
R11365 T20751 T20751 ROOT stimulates,stimulates
R11366 T20983 T20979 appos activation,]
R11367 T20984 T20983 prep through,activation
R11368 T21043 T21046 nsubjpass pathway,involved
R11369 T20985 T20987 amod anti-CD3,anti-CD28
R11370 T20986 T20987 compound /,anti-CD28
R11371 T20987 T20984 pobj anti-CD28,through
R11372 T21044 T21046 auxpass was,involved
R11373 T20988 T20989 advmod also,increases
R11374 T20989 T20989 ROOT increases,increases
R11375 T20990 T20991 compound IL-17,induction
R11376 T20991 T20989 dobj induction,increases
R11377 T20992 T20991 prep in,induction
R11378 T20993 T20994 compound RA,PBMC
R11379 T20994 T20992 pobj PBMC,in
R11380 T21045 T21046 advmod mainly,involved
R11381 T20995 T20989 punct .,increases
R11382 T20996 T21009 mark Although,documented
R11383 T20997 T20999 det the,pathway
R11384 T21046 T21040 ccomp involved,examined
R11385 T20998 T20999 amod signaling,pathway
R11386 T20999 T21009 nsubjpass pathway,documented
R11387 T21000 T20999 prep for,pathway
R11388 T21001 T21002 det the,induction
R11389 T21047 T21046 prep in,involved
R11390 T21002 T21000 pobj induction,for
R11391 T21003 T21002 prep of,induction
R11392 T21004 T21003 pobj cytokines/chemokines,of
R11393 T21048 T21049 det the,induction
R11394 T21005 T21002 prep by,induction
R11395 T21049 T21047 pobj induction,in
R11396 T21006 T21005 pobj IL-17,by
R11397 T21007 T21009 aux has,documented
R11398 T21050 T21049 prep of,induction
R11399 T21008 T21009 auxpass been,documented
R11400 T21009 T21018 advcl documented,been
R11401 T21010 T21009 advmod widely,documented
R11402 T21051 T21050 pobj IL-17,of
R11403 T21011 T21013 compound [,]
R11404 T21012 T21013 compound "8,30,31",]
R11405 T21052 T21049 prep in,induction
R11406 T21013 T21009 oprd ],documented
R11407 T21014 T21018 punct ",",been
R11408 T21015 T21016 det no,data
R11409 T21053 T21054 compound RA,PBMC
R11410 T21016 T21018 nsubj data,been
R11411 T21017 T21018 aux have,been
R11412 T21018 T21018 ROOT been,been
R11413 T21054 T21052 pobj PBMC,in
R11414 T21019 T21018 acomp available,been
R11415 T21020 T21019 prep on,available
R11416 T21021 T21026 advmod how,regulated
R11417 T21055 T21040 punct .,examined
R11418 T21022 T21023 compound IL-17,production
R11419 T21023 T21026 nsubjpass production,regulated
R11420 T21024 T21026 aux can,regulated
R11421 T21056 T21057 nsubj We,identified
R11422 T21025 T21026 auxpass be,regulated
R11423 T21026 T21020 pcomp regulated,on
R11424 T21027 T21026 agent by,regulated
R11425 T21028 T21030 amod certain,pathways
R11426 T21029 T21030 compound signaling,pathways
R11427 T21030 T21027 pobj pathways,by
R11428 T21057 T21057 ROOT identified,identified
R11429 T21031 T21018 punct .,been
R11430 T21032 T21040 prep By,examined
R11431 T21033 T21032 pcomp using,By
R11432 T21034 T21036 compound signal,inhibitors
R11433 T21058 T21067 mark that,hampered
R11434 T21035 T21036 compound transduction,inhibitors
R11435 T21036 T21033 dobj inhibitors,using
R11436 T21037 T21040 punct ",",examined
R11437 T21059 T21061 amod anti-CD3-induced,production
R11438 T21038 T21040 nsubj we,examined
R11439 T21039 T21040 advmod therefore,examined
R11440 T21040 T21040 ROOT examined,examined
R11441 T21060 T21061 compound IL-17,production
R11442 T21041 T21043 det which,pathway
R11443 T21042 T21043 amod signaling,pathway
R11444 T21061 T21067 nsubjpass production,hampered
R11445 T21062 T21061 prep in,production
R11446 T21063 T21064 compound RA,PBMC
R11447 T21140 T21128 conj stimulate,activated
R11448 T21141 T21140 dobj NF-κB,stimulate
R11449 T21064 T21062 pobj PBMC,in
R11450 T21142 T21140 prep by,stimulate
R11451 T21143 T21144 det a,mechanism
R11452 T21065 T21067 auxpass was,hampered
R11453 T21144 T21142 pobj mechanism,by
R11454 T21145 T21144 acl involving,mechanism
R11455 T21066 T21067 advmod significantly,hampered
R11456 T21067 T21057 ccomp hampered,identified
R11457 T21068 T21067 agent by,hampered
R11458 T21146 T21149 nmod histone,protein
R11459 T21069 T21071 det the,inhibitor
R11460 T21147 T21149 nmod acetylase,protein
R11461 T21148 T21149 compound p300/CREB-binding,protein
R11462 T21149 T21145 dobj protein,involving
R11463 T21070 T21071 compound PI3K,inhibitor
R11464 T21150 T21152 nmod [,]
R11465 T21151 T21152 nummod 33,]
R11466 T21071 T21068 pobj inhibitor,by
R11467 T21152 T21149 appos ],protein
R11468 T21153 T21140 punct .,stimulate
R11469 T21154 T21155 poss Our,results
R11470 T21072 T21071 appos LY294002,inhibitor
R11471 T21155 T21156 nsubj results,revealed
R11472 T21156 T21156 ROOT revealed,revealed
R11473 T21157 T21163 mark that,affected
R11474 T21158 T21160 compound p38,activation
R11475 T21159 T21160 compound MAPK,activation
R11476 T21160 T21163 nsubjpass activation,affected
R11477 T21073 T21072 cc and,LY294002
R11478 T21161 T21163 auxpass was,affected
R11479 T21074 T21076 det the,inhibitor
R11480 T21162 T21163 neg not,affected
R11481 T21163 T21156 ccomp affected,revealed
R11482 T21075 T21076 compound NF-κB,inhibitor
R11483 T21164 T21163 agent by,affected
R11484 T21165 T21164 pobj LY294002,by
R11485 T21166 T21163 punct ",",affected
R11486 T21076 T21078 dep inhibitor,to
R11487 T21167 T21172 mark whereas,decreased
R11488 T21168 T21170 nmod NF-κB,activity
R11489 T21169 T21170 amod binding,activity
R11490 T21077 T21076 appos PDTC,inhibitor
R11491 T21170 T21172 nsubjpass activity,decreased
R11492 T21171 T21172 auxpass was,decreased
R11493 T21078 T21067 prep to,hampered
R11494 T21172 T21163 advcl decreased,affected
R11495 T21173 T21172 agent by,decreased
R11496 T21174 T21173 pobj LY294002,by
R11497 T21079 T21080 amod comparable,levels
R11498 T21175 T21174 punct ",",LY294002
R11499 T21176 T21177 nsubj which,provided
R11500 T21080 T21078 pobj levels,to
R11501 T21177 T21174 relcl provided,LY294002
R11502 T21178 T21179 det the,evidence
R11503 T21179 T21177 dobj evidence,provided
R11504 T21081 T21080 prep of,levels
R11505 T21180 T21179 prep for,evidence
R11506 T21181 T21184 det a,pathway
R11507 T21082 T21083 amod basal,production
R11508 T21182 T21184 amod p38,pathway
R11509 T21183 T21184 compound MAPK,pathway
R11510 T21184 T21180 pobj pathway,for
R11511 T21185 T21184 amod independent,pathway
R11512 T21083 T21081 pobj production,of
R11513 T21186 T21185 prep of,independent
R11514 T21187 T21188 nummod PI3K,activation
R11515 T21084 T21067 prep without,hampered
R11516 T21188 T21186 pobj activation,of
R11517 T21189 T21156 punct .,revealed
R11518 T21190 T21192 det The,relationship
R11519 T21085 T21084 pobj stimulation,without
R11520 T21191 T21192 amod direct,relationship
R11521 T21192 T21200 nsubj relationship,needs
R11522 T21193 T21192 prep between,relationship
R11523 T21086 T21057 punct .,identified
R11524 T21194 T21193 pobj p38,between
R11525 T21195 T21194 cc and,p38
R11526 T21196 T21194 conj NF-κB,p38
R11527 T21197 T21196 prep for,NF-κB
R11528 T21198 T21199 compound IL-17,production
R11529 T21199 T21197 pobj production,for
R11530 T21087 T21089 nsubj We,found
R11531 T21200 T21200 ROOT needs,needs
R11532 T21201 T21203 aux to,studied
R11533 T21088 T21089 advmod also,found
R11534 T21202 T21203 auxpass be,studied
R11535 T21203 T21200 xcomp studied,needs
R11536 T21204 T21203 prep in,studied
R11537 T21205 T21206 amod future,experiments
R11538 T21089 T21089 ROOT found,found
R11539 T21206 T21204 pobj experiments,in
R11540 T21207 T21200 punct .,needs
R11541 T21090 T21094 mark that,was
R11542 T21208 T21209 det The,search
R11543 T21209 T21216 nsubj search,seemed
R11544 T21210 T21209 prep for,search
R11545 T21091 T21093 amod anti-CD3-induced,production
R11546 T21211 T21213 det a,pathway
R11547 T21212 T21213 amod downstream,pathway
R11548 T21213 T21210 pobj pathway,for
R11549 T21092 T21093 compound IL-17,production
R11550 T21214 T21213 prep of,pathway
R11551 T21215 T21214 pobj PI3K,of
R11552 T21216 T21216 ROOT seemed,seemed
R11553 T21093 T21094 nsubj production,was
R11554 T21217 T21218 aux to,have
R11555 T21218 T21216 xcomp have,seemed
R11556 T21094 T21095 auxpass was,downregulated
R11557 T21219 T21221 det a,response
R11558 T21220 T21221 amod maximal,response
R11559 T21221 T21218 dobj response,have
R11560 T21095 T21089 ccomp downregulated,found
R11561 T21222 T21221 prep of,response
R11562 T21223 T21224 compound Akt,activation
R11563 T21096 T21095 agent by,downregulated
R11564 T21224 T21222 pobj activation,of
R11565 T21225 T21218 prep at,have
R11566 T21226 T21227 nummod 1,hour
R11567 T21227 T21225 pobj hour,at
R11568 T21097 T21098 det the,addition
R11569 T21228 T21227 cc and,hour
R11570 T21229 T21231 det a,loss
R11571 T21098 T21096 pobj addition,by
R11572 T21230 T21231 amod gradual,loss
R11573 T21231 T21227 conj loss,hour
R11574 T21232 T21231 prep of,loss
R11575 T21233 T21232 pobj activity,of
R11576 T21234 T21231 prep at,loss
R11577 T21235 T21236 nummod 2,hours
R11578 T21099 T21098 prep of,addition
R11579 T21236 T21234 pobj hours,at
R11580 T21100 T21099 pobj SB203580,of
R11581 T21101 T21100 punct ",",SB203580
R11582 T21102 T21105 det a,inhibitor
R11583 T21237 T21216 punct .,seemed
R11584 T21238 T21239 det The,fact
R11585 T21103 T21105 amod p38,inhibitor
R11586 T21239 T21239 ROOT fact,fact
R11587 T21104 T21105 compound MAPK,inhibitor
R11588 T21240 T21242 mark that,is
R11589 T21241 T21242 nsubj Akt,is
R11590 T21105 T21100 appos inhibitor,SB203580
R11591 T21106 T21089 punct .,found
R11592 T21107 T21108 nsubj It,is
R11593 T21242 T21239 acl is,fact
R11594 T21108 T21108 ROOT is,is
R11595 T21243 T21242 acomp phosphorylated,is
R11596 T21244 T21243 prep upon,phosphorylated
R11597 T21245 T21246 amod anti-CD3,stimulation
R11598 T21109 T21108 acomp interesting,is
R11599 T21246 T21244 pobj stimulation,upon
R11600 T21247 T21243 auxpass suggests,phosphorylated
R11601 T21248 T21250 det the,involvement
R11602 T21110 T21115 mark that,supports
R11603 T21249 T21250 amod possible,involvement
R11604 T21250 T21247 dobj involvement,suggests
R11605 T21111 T21112 det a,series
R11606 T21251 T21250 prep of,involvement
R11607 T21252 T21251 pobj PI3K,of
R11608 T21253 T21250 prep in,involvement
R11609 T21254 T21255 det the,induction
R11610 T21112 T21115 nsubj series,supports
R11611 T21255 T21253 pobj induction,in
R11612 T21256 T21255 prep of,induction
R11613 T21257 T21256 pobj IL-17,of
R11614 T21113 T21112 prep of,series
R11615 T21258 T21255 prep in,induction
R11616 T21259 T21258 pobj RA,in
R11617 T21260 T21239 punct .,fact
R11618 T21114 T21113 pobj evidence,of
R11619 T21261 T21284 prep In,is
R11620 T21262 T21261 pobj view,In
R11621 T21263 T21262 prep of,view
R11622 T21115 T21108 ccomp supports,is
R11623 T21264 T21265 det the,fact
R11624 T21265 T21263 pobj fact,of
R11625 T21116 T21115 dobj crosstalk,supports
R11626 T21266 T21270 mark that,activated
R11627 T21267 T21270 nsubjpass NF-κB,activated
R11628 T21268 T21270 auxpass was,activated
R11629 T21269 T21270 advmod also,activated
R11630 T21270 T21265 acl activated,fact
R11631 T21271 T21270 agent by,activated
R11632 T21272 T21274 amod anti-CD3,anti-CD28
R11633 T21117 T21116 prep between,crosstalk
R11634 T21273 T21274 compound /,anti-CD28
R11635 T21274 T21271 pobj anti-CD28,by
R11636 T21275 T21274 punct ",",anti-CD28
R11637 T21276 T21274 conj IL-15,anti-CD28
R11638 T21118 T21117 pobj NF-κB,between
R11639 T21277 T21276 cc or,IL-15
R11640 T21119 T21118 cc and,NF-κB
R11641 T21120 T21118 conj p38,NF-κB
R11642 T21121 T21108 punct .,is
R11643 T21278 T21276 conj mitogens,IL-15
R11644 T21279 T21278 prep in,mitogens
R11645 T21280 T21281 poss our,experiments
R11646 T21281 T21279 pobj experiments,in
R11647 T21122 T21128 prep In,activated
R11648 T21282 T21284 punct ",",is
R11649 T21283 T21284 nsubj it,is
R11650 T21123 T21122 pobj myocytes,In
R11651 T21284 T21284 ROOT is,is
R11652 T21285 T21286 advmod most,likely
R11653 T21286 T21284 acomp likely,is
R11654 T21124 T21128 punct ",",activated
R11655 T21287 T21294 mark that,involved
R11656 T21288 T21290 det the,pathway
R11657 T21289 T21290 compound NF-κB,pathway
R11658 T21290 T21294 nsubjpass pathway,involved
R11659 T21125 T21126 compound IκB,kinase-β
R11660 T21291 T21294 auxpass is,involved
R11661 T21292 T21294 advmod also,involved
R11662 T21293 T21294 advmod actively,involved
R11663 T21126 T21128 nsubjpass kinase-β,activated
R11664 T21294 T21286 ccomp involved,likely
R11665 T21295 T21294 prep in,involved
R11666 T21296 T21297 det the,induction
R11667 T21127 T21128 auxpass is,activated
R11668 T21297 T21295 pobj induction,in
R11669 T21298 T21297 prep of,induction
R11670 T21299 T21298 pobj IL-17,of
R11671 T21128 T21128 ROOT activated,activated
R11672 T21300 T21297 prep in,induction
R11673 T21301 T21302 compound RA,PBMC
R11674 T21302 T21300 pobj PBMC,in
R11675 T21129 T21128 agent by,activated
R11676 T21303 T21284 punct .,is
R11677 T21304 T21322 prep In,activated
R11678 T21305 T21304 pobj contrast,In
R11679 T21306 T21322 punct ",",activated
R11680 T21307 T21311 det the,pathway
R11681 T21308 T21311 compound AP-1,pathway
R11682 T21130 T21133 nummod p38,]
R11683 T21309 T21311 compound signal,pathway
R11684 T21310 T21311 compound transduction,pathway
R11685 T21311 T21322 nsubjpass pathway,activated
R11686 T21312 T21311 punct ",",pathway
R11687 T21131 T21133 nmod [,]
R11688 T21313 T21316 det another,pathway
R11689 T21314 T21316 amod important,pathway
R11690 T21132 T21133 nummod 32,]
R11691 T21315 T21316 amod signaling,pathway
R11692 T21316 T21311 conj pathway,pathway
R11693 T21317 T21316 prep for,pathway
R11694 T21133 T21129 pobj ],by
R11695 T21318 T21317 pobj cytokines/chemokines,for
R11696 T21134 T21128 punct ",",activated
R11697 T21135 T21128 cc and,activated
R11698 T21319 T21322 punct ",",activated
R11699 T21320 T21322 auxpass was,activated
R11700 T21136 T21138 det the,p38
R11701 T21321 T21322 neg not,activated
R11702 T21322 T21322 ROOT activated,activated
R11703 T21323 T21322 prep in,activated
R11704 T21137 T21138 amod activated,p38
R11705 T21324 T21325 poss our,experiments
R11706 T21325 T21323 pobj experiments,in
R11707 T21326 T21325 punct (,experiments
R11708 T21138 T21140 nsubj p38,stimulate
R11709 T21327 T21329 nsubj data,shown
R11710 T21328 T21329 neg not,shown
R11711 T21139 T21140 aux can,stimulate
R11712 T21329 T21322 conj shown,activated
R11713 T21330 T21329 punct ),shown
R11714 T21331 T21322 punct .,activated
R11715 T21332 T21345 mark Although,reported
R11716 T21334 T21333 cc and,PI3K
R11717 T21333 T21345 nsubjpass PI3K,reported
R11718 T21335 T21337 poss its,kinase
R11719 T21431 T21432 nsubj IL-17,signaling
R11720 T21432 T21434 nsubj signaling,is
R11721 T21433 T21434 nsubj pathway,is
R11722 T21336 T21337 amod downstream,kinase
R11723 T21434 T21429 ccomp is,understanding
R11724 T21435 T21437 det an,element
R11725 T21436 T21437 amod important,element
R11726 T21437 T21434 attr element,is
R11727 T21438 T21437 prep of,element
R11728 T21439 T21438 pcomp developing,of
R11729 T21440 T21442 amod new,therapies
R11730 T21337 T21338 compound kinase,Akt
R11731 T21441 T21442 amod targeted,therapies
R11732 T21442 T21439 dobj therapies,developing
R11733 T21443 T21439 prep in,developing
R11734 T21444 T21443 pobj RA,in
R11735 T21338 T21333 conj Akt,PI3K
R11736 T21445 T21410 punct .,Considering
R11737 T21339 T21333 prep in,PI3K
R11738 T21340 T21339 pobj association,in
R11739 T21341 T21340 prep with,association
R11740 T21342 T21341 pobj NF-κB,with
R11741 T21343 T21345 aux have,reported
R11742 T21344 T21345 auxpass been,reported
R11743 T21345 T21363 advcl reported,lacking
R11744 T21346 T21347 aux to,deliver
R11745 T21347 T21345 xcomp deliver,reported
R11746 T21348 T21349 amod activating,signals
R11747 T21349 T21347 dobj signals,deliver
R11750 T21350 T21347 prep in,deliver
R11752 T21351 T21353 amod many,types
R11753 T21352 T21353 compound cell,types
R11754 T21353 T21350 pobj types,in
R11755 T21354 T21363 punct ",",lacking
R11756 T21355 T21356 det the,data
R11757 T21356 T21363 nsubj data,lacking
R11759 T21357 T21356 prep on,data
R11761 T21358 T21359 det the,signal
R11762 T21359 T21357 pobj signal,on
R11764 T21360 T21359 acl inducing,signal
R11766 T21361 T21360 dobj IL-17,inducing
R11767 T21362 T21363 aux are,lacking
R11770 T21363 T21363 ROOT lacking,lacking
R11772 T21364 T21363 punct .,lacking
R11775 T21365 T21366 poss Our,data
R11780 T21366 T21368 nsubj data,demonstrated
R11781 T21367 T21368 advmod clearly,demonstrated
R11783 T21368 T21368 ROOT demonstrated,demonstrated
R11786 T21369 T21376 mark that,be
R11789 T21370 T21376 nsubj PI3K/Akt,be
R11793 T21371 T21370 cc and,PI3K/Akt
R11794 T21372 T21374 amod resultant,activation
R11795 T21373 T21374 compound NF-κB,activation
R11797 T21374 T21370 conj activation,PI3K/Akt
R11800 T21375 T21376 aux could,be
R11811 T21376 T21368 ccomp be,demonstrated
R11813 T21377 T21379 det an,arbitrator
R11814 T21378 T21379 amod important,arbitrator
R11817 T21379 T21376 attr arbitrator,be
R11821 T21380 T21379 prep of,arbitrator
R11822 T21381 T21382 det the,upregulation
R11823 T21382 T21380 pobj upregulation,of
R11828 T21383 T21382 prep of,upregulation
R11831 T21384 T21383 pobj IL-17,of
R11833 T21385 T21382 prep in,upregulation
R11835 T21386 T21385 pobj RA,in
R11840 T21387 T21379 punct ",",arbitrator
R11841 T21388 T21379 prep on,arbitrator
R11843 T21389 T21390 det the,basis
R11844 T21390 T21388 pobj basis,on
R11845 T21391 T21390 prep of,basis
R11846 T21392 T21393 poss our,experiments
R11848 T21393 T21391 pobj experiments,of
R11849 T21394 T21393 acl showing,experiments
R11853 T21395 T21396 amod simultaneous,blocking
R11855 T21396 T21394 dobj blocking,showing
R11858 T21397 T21396 prep of,blocking
R11860 T21398 T21400 amod NF-κB,activity
R11862 T21399 T21400 amod binding,activity
R11864 T21400 T21397 pobj activity,of
R11866 T21401 T21400 prep in,activity
R11868 T21402 T21404 det the,promoter
R11871 T21403 T21404 compound IL-17,promoter
R11872 T21404 T21401 pobj promoter,in
R11874 T21405 T21396 prep by,blocking
R11883 T21406 T21405 pobj PDTC,by
R11884 T21407 T21406 cc and,PDTC
R11887 T21408 T21406 conj LY294002,PDTC
R11890 T21409 T21368 punct .,demonstrated
R11893 T21410 T21410 ROOT Considering,Considering
R11895 T21411 T21413 poss its,activities
R11898 T21412 T21413 amod proinflammatory,activities
R11900 T21413 T21410 dobj activities,Considering
R11902 T21414 T21413 cc and,activities
R11903 T21415 T21416 amod successful,induction
R11908 T21416 T21413 conj induction,activities
R11914 T21417 T21416 prep of,induction
R11916 T21418 T21417 pobj anti-IL-17,of
R11917 T21419 T21418 prep for,anti-IL-17
R11918 T21420 T21419 pcomp ameliorating,for
R11919 T21421 T21420 dobj arthritis,ameliorating
R11920 T21422 T21420 prep in,ameliorating
R11921 T21423 T21424 compound animal,models
R11922 T21424 T21422 pobj models,in
R11923 T21425 T21427 compound [,]
R11926 T21426 T21427 compound "2,6,34-36",]
R11927 T21427 T21424 appos ],models
R11928 T21428 T21427 punct ",",]
R11929 T21429 T21420 conj understanding,ameliorating
R11930 T21430 T21431 det the,IL-17
R10801 T20418 T20417 cc and,IL-1
R10802 T20419 T20417 conj TNF-α,IL-1
R10803 T20420 T20420 ROOT are,are
R10804 T20421 T20420 acomp abundant,are
R10805 T20422 T20421 prep in,abundant
R10806 T20423 T20424 amod rheumatoid,synovium
R10807 T20424 T20422 pobj synovium,in
R10808 T20425 T20420 punct ",",are
R10809 T20426 T20439 mark whereas,proved
R10810 T20427 T20430 det the,cytokines
R10811 T20428 T20430 nmod T,cytokines
R10812 T20429 T20430 amod cell-derived,cytokines
R10813 T20430 T20439 nsubj cytokines,proved
R10814 T20431 T20430 punct ",",cytokines
R10815 T20432 T20433 advmod especially,IL-4
R10816 T20433 T20430 appos IL-4,cytokines
R10817 T20434 T20433 cc and,IL-4
R10818 T20435 T20433 conj interferon-γ,IL-4
R10819 T20436 T20439 punct ",",proved
R10820 T20437 T20439 aux have,proved
R10821 T20438 T20439 advmod often,proved
R10822 T20439 T20420 advcl proved,are
R10823 T20440 T20439 oprd difficult,proved
R10824 T20441 T20442 aux to,detect
R10825 T20442 T20440 xcomp detect,difficult
R10826 T20443 T20442 prep in,detect
R10827 T20444 T20445 compound RA,synovium
R10828 T20445 T20446 compound synovium,[
R10853 T20470 T20467 pobj cytokines,of
R10854 T20471 T20472 aux has,limited
R10855 T20472 T20472 ROOT limited,limited
R10856 T20473 T20474 poss its,importance
R10857 T20474 T20472 dobj importance,limited
R10858 T20475 T20472 punct .,limited
R10859 T20476 T20482 prep In,appealing
R10860 T20477 T20478 det this,respect
R10861 T20478 T20476 pobj respect,In
R10862 T20479 T20482 punct ",",appealing
R10863 T20480 T20482 nsubj IL-17,appealing
R10864 T20481 T20482 aux is,appealing
R10865 T20482 T20482 ROOT appealing,appealing
R10866 T20483 T20487 mark because,described
R10867 T20484 T20487 nsubjpass it,described

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T19792 5904-5913 Positive_regulation denotes induction
T19791 6003-6008 Protein denotes IL-17
T19790 5917-5927 Protein denotes anti-IL-17
T19789 5767-5775 Negative_regulation denotes blocking
T19788 5767-5775 Negative_regulation denotes blocking
T19787 5767-5775 Negative_regulation denotes blocking
T19786 5767-5775 Negative_regulation denotes blocking
T19785 5785-5792 Binding denotes binding
T19784 5785-5792 Binding denotes binding
T19783 5785-5792 Binding denotes binding
T19782 5785-5792 Binding denotes binding
T19781 5634-5644 Positive_regulation denotes activation
T19780 5809-5823 Protein denotes IL-17 promoter
T19779 5779-5784 Protein denotes NF-κB
T19778 5628-5633 Protein denotes NF-κB
T19777 5610-5613 Protein denotes Akt
T19776 5605-5609 Protein denotes PI3K
T19775 5427-5438 Binding denotes association
T19774 5427-5438 Binding denotes association
T19773 5551-5556 Protein denotes IL-17
T19772 5444-5449 Protein denotes NF-κB
T19771 5420-5423 Protein denotes Akt
T19770 5389-5393 Protein denotes PI3K
T19769 5229-5233 Protein denotes AP-1
T19768 5165-5173 Regulation denotes involved
T19767 5165-5173 Regulation denotes involved
T19766 5181-5190 Positive_regulation denotes induction
T19765 5181-5190 Positive_regulation denotes induction
T19764 5036-5045 Positive_regulation denotes activated
T19763 5036-5045 Positive_regulation denotes activated
T19762 5036-5045 Positive_regulation denotes activated
T19761 5203-5210 Protein denotes RA PBMC
T19760 5194-5199 Protein denotes IL-17
T19759 5134-5139 Protein denotes NF-κB
T19758 5069-5074 Protein denotes IL-15
T19713 3923-3928 Protein denotes NF-κB
T19712 3906-3914 Protein denotes LY294002
T19711 3891-3895 Protein denotes PI3K
T19710 3849-3856 Protein denotes RA PBMC
T19709 3817-3820 Protein denotes CD3
T19708 3762-3771 Positive_regulation denotes induction
T19707 3784-3791 Protein denotes RA PBMC
T19706 3775-3780 Protein denotes IL-17
T19705 3607-3616 Regulation denotes regulated
T19704 3589-3599 Gene_expression denotes production
T19703 3583-3588 Protein denotes IL-17
T19702 3504-3509 Protein denotes IL-17
T19701 3390-3399 Positive_regulation denotes increases
T19700 3390-3399 Positive_regulation denotes increases
T19699 3406-3415 Positive_regulation denotes induction
T19698 3406-3415 Positive_regulation denotes induction
T19697 3419-3426 Protein denotes RA PBMC
T19696 3400-3405 Protein denotes IL-17
T19695 3380-3384 Protein denotes CD28
T19694 3366-3379 Protein denotes anti-CD3/anti
T19693 3087-3092 Protein denotes TNF-α
T19692 3032-3037 Protein denotes IL-15
T19691 2956-2962 Regulation denotes affect
T19690 2956-2962 Regulation denotes affect
T19689 2969-2979 Gene_expression denotes production
T19688 2963-2968 Protein denotes IL-17
T19687 2856-2861 Protein denotes TNF-α
T19686 2847-2851 Protein denotes IL-1
T19685 2783-2791 Binding denotes ligation
T19684 2779-2782 Protein denotes TCR
T19683 2770-2775 Protein denotes MCP-1
T19682 2761-2766 Protein denotes IL-15
T19681 2708-2717 Positive_regulation denotes increased
T19680 2708-2717 Positive_regulation denotes increased
T19679 2708-2717 Positive_regulation denotes increased
T19678 2708-2717 Positive_regulation denotes increased
T19677 2708-2717 Positive_regulation denotes increased
T19676 2708-2717 Positive_regulation denotes increased
T19675 2708-2717 Positive_regulation denotes increased
T19674 2708-2717 Positive_regulation denotes increased
T19673 2722-2732 Gene_expression denotes production
T19672 2722-2732 Gene_expression denotes production
T19671 2685-2693 Binding denotes ligation
T19670 2685-2693 Binding denotes ligation
T19669 2745-2752 Protein denotes RA PBMC
T19668 2736-2741 Protein denotes IL-17
T19667 2681-2684 Protein denotes TCR
T19666 2664-2669 Protein denotes MCP-1
T19665 2654-2659 Protein denotes IL-15
T19664 2589-2597 Binding denotes ligation
T19663 2589-2597 Binding denotes ligation
T19662 2464-2474 Gene_expression denotes production
T19661 2464-2474 Gene_expression denotes production
T19660 2613-2622 Protein denotes anti-CD28
T19659 2609-2612 Protein denotes CD3
T19658 2584-2587 Protein denotes TCR
T19657 2567-2582 Protein denotes T cell receptor
T19656 2487-2494 Protein denotes RA PBMC
T19655 2478-2483 Protein denotes IL-17
T19654 2295-2304 Positive_regulation denotes stimulate
T19653 2311-2321 Gene_expression denotes production
T19652 2305-2310 Protein denotes IL-17
T19651 2102-2109 Localization denotes secrete
T19638 1493-1498 Protein denotes IL-17
T19637 1388-1400 Positive_regulation denotes upregulation
T19636 1404-1409 Protein denotes IL-17
T19635 1235-1250 Protein denotes T cell receptor
T19634 1199-1208 Protein denotes anti-CD28
T19633 1195-1198 Protein denotes CD3
T19632 982-991 Positive_regulation denotes stimulate
T19631 1052-1062 Gene_expression denotes production
T19630 998-1008 Gene_expression denotes production
T19629 1096-1100 Protein denotes CD28
T19628 1087-1090 Protein denotes CD3
T19627 1046-1051 Protein denotes IL-17
T19626 992-997 Protein denotes IL-17
T19625 356-368 Protein denotes interferon-γ
T19624 347-351 Protein denotes IL-4
T19623 255-260 Protein denotes TNF-α
T19622 246-250 Protein denotes IL-1
T19621 11-16 Protein denotes IL-17
T19650 2102-2109 Localization denotes secrete
T19649 2102-2109 Localization denotes secrete
T19648 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T19647 2142-2146 Protein denotes IL-8
T19646 2136-2140 Protein denotes IL-6
T19645 1777-1786 Positive_regulation denotes augmented
T19644 1798-1809 Binding denotes recognizing
T19643 1832-1840 Protein denotes collagen
T19642 1810-1826 Protein denotes type II collagen
T19641 1639-1643 Protein denotes CD8+
T19640 1502-1510 Gene_expression denotes produced
T19639 1531-1534 Protein denotes CD4
T19719 4117-4126 Negative_regulation denotes inhibitor
T19718 4108-4116 Protein denotes p38 MAPK
T19717 4030-4033 Protein denotes CD3
T19716 3821-3828 Positive_regulation denotes induced
T19715 3875-3883 Positive_regulation denotes hampered
T19714 3835-3845 Gene_expression denotes production
T19757 5058-5067 Protein denotes anti-CD28
T19756 5049-5057 Protein denotes anti-CD3
T19755 5021-5026 Protein denotes NF-κB
T19754 4943-4954 Regulation denotes involvement
T19753 4970-4979 Positive_regulation denotes induction
T19752 4880-4894 Phosphorylation denotes phosphorylated
T19751 4983-4988 Protein denotes IL-17
T19750 4958-4962 Protein denotes PI3K
T19749 4905-4908 Protein denotes CD3
T19748 4873-4876 Protein denotes Akt
T19747 4830-4834 Negative_regulation denotes loss
T19746 4795-4805 Positive_regulation denotes activation
T19745 4791-4794 Protein denotes Akt
T19744 4749-4753 Protein denotes PI3K
T19743 4656-4666 Gene_expression denotes production
T19742 4650-4655 Protein denotes IL-17
T19741 4640-4645 Protein denotes NF-κB
T19740 4632-4635 Protein denotes p38
T19739 4588-4598 Positive_regulation denotes activation
T19738 4494-4503 Negative_regulation denotes decreased
T19737 4473-4480 Binding denotes binding
T19736 4437-4445 Regulation denotes affected
T19735 4418-4428 Positive_regulation denotes activation
T19734 4583-4587 Protein denotes PI3K
T19733 4551-4554 Protein denotes p38
T19732 4467-4472 Protein denotes NF-κB
T19731 4409-4417 Protein denotes p38 MAPK
T19730 4361-4368 Binding denotes binding
T19729 4292-4301 Positive_regulation denotes stimulate
T19728 4274-4283 Positive_regulation denotes activated
T19727 4243-4252 Positive_regulation denotes activated
T19726 4356-4360 Protein denotes CREB
T19725 4333-4355 Protein denotes histone acetylase p300
T19724 4302-4307 Protein denotes NF-κB
T19723 4284-4287 Protein denotes p38
T19722 4227-4239 Protein denotes IκB kinase-β
T19721 4209-4212 Protein denotes p38
T19720 4199-4204 Protein denotes NF-κB
R10483 T19626 T19630 themeOf IL-17,production
R10484 T19627 T19631 themeOf IL-17,production
R10485 T19630 T19632 themeOf production,stimulate
R10486 T19636 T19637 themeOf IL-17,upregulation
R10487 T19638 T19640 themeOf IL-17,produced
R10488 T19642 T19644 themeOf type II collagen,recognizing
R10489 T19644 T19645 themeOf recognizing,augmented
R10490 T19646 T19649 themeOf IL-6,secrete
R10491 T19647 T19650 themeOf IL-8,secrete
R10492 T19648 T19651 themeOf tumor necrosis factor-stimulated gene 6,secrete
R10493 T19652 T19653 themeOf IL-17,production
R10494 T19653 T19654 themeOf production,stimulate
R10495 T19655 T19661 themeOf IL-17,production
R10496 T19656 T19662 themeOf RA PBMC,production
R10497 T19657 T19663 themeOf T cell receptor,ligation
R10498 T19658 T19664 themeOf TCR,ligation
R10499 T19665 T19671 themeOf IL-15,ligation
R10500 T19665 T19674 causeOf IL-15,increased
R10501 T19665 T19675 causeOf IL-15,increased
R10502 T19666 T19676 causeOf MCP-1,increased
R10503 T19666 T19677 causeOf MCP-1,increased
R10504 T19667 T19670 themeOf TCR,ligation
R10505 T19667 T19671 themeOf TCR,ligation
R10506 T19668 T19672 themeOf IL-17,production
R10507 T19669 T19673 themeOf RA PBMC,production
R10508 T19670 T19678 causeOf ligation,increased
R10509 T19670 T19679 causeOf ligation,increased
R10510 T19671 T19680 causeOf ligation,increased
R10511 T19671 T19681 causeOf ligation,increased
R10512 T19672 T19674 themeOf production,increased
R10513 T19672 T19676 themeOf production,increased
R10514 T19672 T19678 themeOf production,increased
R10515 T19672 T19680 themeOf production,increased
R10516 T19673 T19675 themeOf production,increased
R10517 T19673 T19677 themeOf production,increased
R10518 T19673 T19679 themeOf production,increased
R10519 T19673 T19681 themeOf production,increased
R10520 T19684 T19685 themeOf TCR,ligation
R10521 T19686 T19690 causeOf IL-1,affect
R10522 T19687 T19691 causeOf TNF-α,affect
R10523 T19688 T19689 themeOf IL-17,production
R10524 T19689 T19690 themeOf production,affect
R10525 T19689 T19691 themeOf production,affect
R10526 T19696 T19698 themeOf IL-17,induction
R10527 T19697 T19699 themeOf RA PBMC,induction
R10528 T19698 T19700 themeOf induction,increases
R10529 T19699 T19701 themeOf induction,increases
R10530 T19703 T19704 themeOf IL-17,production
R10531 T19704 T19705 themeOf production,regulated
R10532 T19707 T19708 themeOf RA PBMC,induction
R10533 T19709 T19716 causeOf CD3,induced
R10534 T19710 T19714 themeOf RA PBMC,production
R10535 T19712 T19715 causeOf LY294002,hampered
R10536 T19714 T19715 themeOf production,hampered
R10537 T19714 T19716 themeOf production,induced
R10538 T19718 T19719 themeOf p38 MAPK,inhibitor
R10539 T19722 T19727 themeOf IκB kinase-β,activated
R10540 T19723 T19728 themeOf p38,activated
R10541 T19724 T19729 themeOf NF-κB,stimulate
R10542 T19726 T19730 themeOf CREB,binding
R10543 T19728 T19729 causeOf activated,stimulate
R10544 T19731 T19735 themeOf p38 MAPK,activation
R10545 T19732 T19737 themeOf NF-κB,binding
R10546 T19734 T19739 themeOf PI3K,activation
R10547 T19735 T19736 themeOf activation,affected
R10548 T19737 T19738 themeOf binding,decreased
R10549 T19742 T19743 themeOf IL-17,production
R10550 T19745 T19746 themeOf Akt,activation
R10551 T19746 T19747 themeOf activation,loss
R10552 T19748 T19752 themeOf Akt,phosphorylated
R10553 T19750 T19754 causeOf PI3K,involvement
R10554 T19751 T19753 themeOf IL-17,induction
R10555 T19753 T19754 themeOf induction,involvement
R10556 T19755 T19762 themeOf NF-κB,activated
R10557 T19755 T19763 themeOf NF-κB,activated
R10558 T19755 T19764 themeOf NF-κB,activated
R10559 T19756 T19762 causeOf anti-CD3,activated
R10560 T19757 T19763 causeOf anti-CD28,activated
R10561 T19758 T19764 causeOf IL-15,activated
R10562 T19759 T19767 causeOf NF-κB,involved
R10563 T19759 T19768 causeOf NF-κB,involved
R10564 T19760 T19765 themeOf IL-17,induction
R10565 T19761 T19766 themeOf RA PBMC,induction
R10566 T19765 T19767 themeOf induction,involved
R10567 T19766 T19768 themeOf induction,involved
R10568 T19771 T19775 themeOf Akt,association
R10569 T19772 T19774 themeOf NF-κB,association
R10570 T19772 T19775 themeOf NF-κB,association
R10571 T19777 T19784 themeOf Akt,binding
R10572 T19778 T19781 themeOf NF-κB,activation
R10573 T19779 T19782 themeOf NF-κB,binding
R10574 T19779 T19784 themeOf NF-κB,binding
R10575 T19779 T19785 themeOf NF-κB,binding
R10576 T19780 T19783 themeOf IL-17 promoter,binding
R10577 T19780 T19785 themeOf IL-17 promoter,binding
R10578 T19782 T19786 themeOf binding,blocking
R10579 T19783 T19787 themeOf binding,blocking
R10580 T19784 T19788 themeOf binding,blocking
R10581 T19785 T19789 themeOf binding,blocking
R10582 T19790 T19792 themeOf anti-IL-17,induction

testone

Id Subject Object Predicate Lexical cue
T17026 5815-5823 Entity denotes promoter
T17025 5785-5792 Binding denotes binding
T17024 5767-5775 Negative_regulation denotes blocking
T17023 5685-5697 Positive_regulation denotes upregulation
T17022 5561-5568 Negative_regulation denotes lacking
T17021 5542-5550 Positive_regulation denotes inducing
T17020 5427-5438 Binding denotes association
T17019 5181-5190 Positive_regulation denotes induction
T17018 5165-5173 Regulation denotes involved
T17017 4970-4979 Positive_regulation denotes induction
T17016 4943-4954 Regulation denotes involvement
T17015 4880-4894 Phosphorylation denotes phosphorylated
T17014 4795-4805 Positive_regulation denotes activation
T17013 4656-4666 Gene_expression denotes production
T17012 4494-4503 Negative_regulation denotes decreased
T17011 4473-4480 Binding denotes binding
T17010 4437-4445 Regulation denotes affected
T17009 4274-4283 Positive_regulation denotes activated
T17008 4243-4252 Positive_regulation denotes activated
T17007 4117-4126 Negative_regulation denotes inhibitor
T17006 4063-4076 Negative_regulation denotes downregulated
T17005 4048-4058 Gene_expression denotes production
T17004 4034-4041 Positive_regulation denotes induced
T17003 3974-3984 Gene_expression denotes production
T17002 3875-3883 Negative_regulation denotes hampered
T17001 3835-3845 Gene_expression denotes production
T17000 3821-3828 Positive_regulation denotes induced
T16999 3762-3771 Positive_regulation denotes induction
T16998 3746-3754 Regulation denotes involved
T16997 3607-3616 Regulation denotes regulated
T16996 3589-3599 Gene_expression denotes production
T16995 3406-3415 Positive_regulation denotes induction
T16994 3390-3399 Positive_regulation denotes increases
T16993 3063-3073 Gene_expression denotes production
T16992 3038-3047 Positive_regulation denotes triggered
T16991 2969-2979 Gene_expression denotes production
T16990 2956-2962 Regulation denotes affect
T16989 2924-2933 Positive_regulation denotes increased
T16988 2808-2818 Gene_expression denotes production
T16987 2792-2801 Positive_regulation denotes augmented
T16986 2722-2732 Gene_expression denotes production
T16985 2708-2717 Positive_regulation denotes increased
T16984 2464-2474 Gene_expression denotes production
T16983 2405-2415 Gene_expression denotes production
T16982 2390-2398 Regulation denotes regulate
T16981 2311-2321 Gene_expression denotes production
T16980 2295-2304 Positive_regulation denotes stimulate
T16979 1777-1786 Positive_regulation denotes augmented
T16978 1748-1758 Gene_expression denotes production
T16977 1627-1635 Gene_expression denotes produced
T16976 1502-1510 Gene_expression denotes produced
T16975 1388-1400 Positive_regulation denotes upregulation
T16974 1302-1311 Regulation denotes dependent
T16973 1268-1278 Gene_expression denotes production
T16972 1252-1261 Positive_regulation denotes increased
T16971 1052-1062 Gene_expression denotes production
T16970 998-1008 Gene_expression denotes production
T16969 982-991 Positive_regulation denotes stimulate
T16968 773-782 Regulation denotes regulated
T16967 759-769 Gene_expression denotes production
T16966 6003-6008 Protein denotes IL-17
T16965 5922-5927 Protein denotes IL-17
T16964 5809-5814 Protein denotes IL-17
T16963 5701-5706 Protein denotes IL-17
T16962 5610-5613 Protein denotes Akt
T16961 5551-5556 Protein denotes IL-17
T16960 5420-5423 Protein denotes Akt
T16959 5229-5233 Protein denotes AP-1
T16958 5194-5199 Protein denotes IL-17
T16957 5069-5074 Protein denotes IL-15
T16956 5063-5067 Protein denotes CD28
T16955 4983-4988 Protein denotes IL-17
T16954 4873-4876 Protein denotes Akt
T16953 4791-4794 Protein denotes Akt
T16952 4650-4655 Protein denotes IL-17
T16951 4356-4376 Protein denotes CREB-binding protein
T16950 4351-4355 Protein denotes p300
T16949 4227-4239 Protein denotes IκB kinase-β
T16948 4042-4047 Protein denotes IL-17
T16947 3829-3834 Protein denotes IL-17
T16946 3817-3820 Protein denotes CD3
T16945 3775-3780 Protein denotes IL-17
T16944 3583-3588 Protein denotes IL-17
T16943 3504-3509 Protein denotes IL-17
T16942 3400-3405 Protein denotes IL-17
T16941 3380-3384 Protein denotes CD28
T16940 3146-3151 Protein denotes MCP-1
T16939 3087-3092 Protein denotes TNF-α
T16938 3057-3062 Protein denotes IL-17
T16937 3032-3037 Protein denotes IL-15
T16936 2963-2968 Protein denotes IL-17
T16935 2856-2861 Protein denotes TNF-α
T16934 2847-2851 Protein denotes IL-1
T16933 2802-2807 Protein denotes IL-17
T16932 2770-2775 Protein denotes MCP-1
T16931 2761-2766 Protein denotes IL-15
T16930 2736-2741 Protein denotes IL-17
T16929 2664-2669 Protein denotes MCP-1
T16928 2654-2659 Protein denotes IL-15
T16927 2618-2622 Protein denotes CD28
T16926 2478-2483 Protein denotes IL-17
T16925 2399-2404 Protein denotes IL-17
T16924 2364-2369 Protein denotes IL-23
T16923 2354-2359 Protein denotes IL-15
T16922 2305-2310 Protein denotes IL-17
T16921 2151-2190 Protein denotes tumor necrosis factor-stimulated gene 6
T16920 2142-2146 Protein denotes IL-8
T16919 2136-2140 Protein denotes IL-6
T16918 2058-2063 Protein denotes IL-17
T16917 1742-1747 Protein denotes IL-17
T16916 1659-1664 Protein denotes IL-23
T16915 1639-1642 Protein denotes CD8
T16914 1531-1534 Protein denotes CD4
T16913 1493-1498 Protein denotes IL-17
T16912 1404-1409 Protein denotes IL-17
T16911 1262-1267 Protein denotes IL-17
T16910 1204-1208 Protein denotes CD28
T16909 1162-1165 Protein denotes PHA
T16908 1096-1100 Protein denotes CD28
T16907 1046-1051 Protein denotes IL-17
T16906 992-997 Protein denotes IL-17
T16905 842-847 Protein denotes IL-17
T16904 753-758 Protein denotes IL-17
T16903 601-606 Protein denotes IL-17
T16902 356-368 Protein denotes interferon-γ
T16901 347-351 Protein denotes IL-4
T16900 255-260 Protein denotes TNF-α
T16899 246-250 Protein denotes IL-1
T16898 11-16 Protein denotes IL-17
R9199 T16904 T16967 themeOf IL-17,production
R9200 T16906 T16970 themeOf IL-17,production
R9201 T16907 T16971 themeOf IL-17,production
R9202 T16909 T16972 causeOf PHA,increased
R9203 T16911 T16973 themeOf IL-17,production
R9204 T16912 T16975 themeOf IL-17,upregulation
R9205 T16913 T16976 themeOf IL-17,produced
R9206 T16916 T16977 causeOf IL-23,produced
R9207 T16917 T16978 themeOf IL-17,production
R9208 T16922 T16981 themeOf IL-17,production
R9209 T16924 T16982 causeOf IL-23,regulate
R9210 T16925 T16983 themeOf IL-17,production
R9211 T16926 T16984 themeOf IL-17,production
R9212 T16928 T16985 causeOf IL-15,increased
R9213 T16930 T16986 themeOf IL-17,production
R9214 T16931 T16987 causeOf IL-15,augmented
R9215 T16933 T16988 themeOf IL-17,production
R9216 T16934 T16990 causeOf IL-1,affect
R9217 T16934 T16989 themeOf IL-1,increased
R9218 T16935 T16989 themeOf TNF-α,increased
R9219 T16936 T16991 themeOf IL-17,production
R9220 T16937 T16992 causeOf IL-15,triggered
R9221 T16938 T16993 themeOf IL-17,production
R9222 T16942 T16995 themeOf IL-17,induction
R9223 T16944 T16996 themeOf IL-17,production
R9224 T16945 T16999 themeOf IL-17,induction
R9225 T16946 T17000 causeOf CD3,induced
R9226 T16947 T17001 themeOf IL-17,production
R9227 T16948 T17005 themeOf IL-17,production
R9228 T16949 T17008 themeOf IκB kinase-β,activated
R9229 T16952 T17013 themeOf IL-17,production
R9230 T16953 T17014 themeOf Akt,activation
R9231 T16954 T17015 themeOf Akt,phosphorylated
R9232 T16955 T17017 themeOf IL-17,induction
R9233 T16958 T17019 themeOf IL-17,induction
R9234 T16960 T17020 themeOf Akt,association
R9235 T16961 T17021 themeOf IL-17,inducing
R9236 T16961 T17022 themeOf IL-17,lacking
R9237 T16963 T17023 themeOf IL-17,upregulation
R9238 T16967 T16968 themeOf production,regulated
R9239 T16970 T16969 themeOf production,stimulate
R9240 T16972 T16974 themeOf increased,dependent
R9241 T16973 T16972 themeOf production,increased
R9242 T16973 T16974 themeOf production,dependent
R9243 T16978 T16979 themeOf production,augmented
R9244 T16981 T16980 themeOf production,stimulate
R9245 T16983 T16982 themeOf production,regulate
R9246 T16986 T16985 themeOf production,increased
R9247 T16988 T16987 themeOf production,augmented
R9248 T16991 T16990 themeOf production,affect
R9249 T16993 T16992 themeOf production,triggered
R9250 T16995 T16994 themeOf induction,increases
R9251 T16996 T16997 themeOf production,regulated
R9252 T16999 T16998 themeOf induction,involved
R9253 T17000 T17002 themeOf induced,hampered
R9254 T17001 T17002 themeOf production,hampered
R9255 T17001 T17000 themeOf production,induced
R9256 T17003 T17002 causeOf production,hampered
R9257 T17004 T17006 themeOf induced,downregulated
R9258 T17005 T17006 themeOf production,downregulated
R9259 T17005 T17004 themeOf production,induced
R9260 T17007 T17006 causeOf inhibitor,downregulated
R9261 T17011 T17012 themeOf binding,decreased
R9262 T17017 T17016 themeOf induction,involvement
R9263 T17019 T17018 themeOf induction,involved
R9264 T17025 T17024 themeOf binding,blocking
R9265 T17026 T16964 partOf promoter,IL-17
R9266 T17026 T17025 themeOf promoter,binding