PMC:1064895 / 0-583 JSONTXT

{"project":"test3","denotations":[{"id":"T93","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T94","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T128","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T129","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T130","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T131","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T133","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T132","span":{"begin":273,"end":292},"obj":"Protein"},{"id":"T96","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T95","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R30","pred":"themeOf","subj":"T129","obj":"T130"},{"id":"R31","pred":"themeOf","subj":"T130","obj":"T128"},{"id":"R32","pred":"causeOf","subj":"T131","obj":"T128"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T1281","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T1282","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T1316","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T1317","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T1318","span":{"begin":461,"end":471},"obj":"Gene_expression"},{"id":"T1284","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1283","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R518","pred":"themeOf","subj":"T1281","obj":"T1316"},{"id":"R519","pred":"themeOf","subj":"T1284","obj":"T1318"},{"id":"R532","pred":"themeOf","subj":"T1316","obj":"T1317"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"BioNLP16_DUT","denotations":[{"id":"T1985","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T1986","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T2020","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T2021","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T2022","span":{"begin":461,"end":471},"obj":"Gene_expression"},{"id":"T1988","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1987","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R1038","pred":"themeOf","subj":"T1985","obj":"T2020"},{"id":"R1039","pred":"themeOf","subj":"T2021","obj":"T2020"},{"id":"R1043","pred":"themeOf","subj":"T1985","obj":"T2021"},{"id":"R1045","pred":"themeOf","subj":"T1988","obj":"T2022"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"biosemtest","denotations":[{"id":"T220","span":{"begin":42,"end":58},"obj":"UMLS/C0031621"},{"id":"T245","span":{"begin":115,"end":123},"obj":"UMLS/C1578485"},{"id":"T250","span":{"begin":115,"end":123},"obj":"UMLS/C1578484"},{"id":"T254","span":{"begin":115,"end":123},"obj":"UMLS/C1578486"},{"id":"T258","span":{"begin":115,"end":123},"obj":"UMLS/C1578481"},{"id":"T261","span":{"begin":115,"end":123},"obj":"UMLS/C1578480"},{"id":"T264","span":{"begin":115,"end":123},"obj":"UMLS/C1578483"},{"id":"T276","span":{"begin":115,"end":123},"obj":"UMLS/C1578479"},{"id":"T292","span":{"begin":115,"end":123},"obj":"UMLS/C0030705"},{"id":"T336","span":{"begin":129,"end":149},"obj":"UMLS/C0003873"},{"id":"T366","span":{"begin":36,"end":39},"obj":"UMLS/C1550513"},{"id":"T394","span":{"begin":0,"end":9},"obj":"UMLS/C0442808"},{"id":"T397","span":{"begin":0,"end":9},"obj":"UMLS/C0442805"},{"id":"T402","span":{"begin":68,"end":71},"obj":"UP/Q8INB9"},{"id":"T431","span":{"begin":94,"end":103},"obj":"UMLS/C1701901"},{"id":"T434","span":{"begin":115,"end":123},"obj":"UMLS/C1550655"},{"id":"T439","span":{"begin":76,"end":83},"obj":"UMLS/C0521447"},{"id":"T447","span":{"begin":104,"end":111},"obj":"UMLS/C1704259"},{"id":"T461","span":{"begin":0,"end":9},"obj":"UMLS/C0205217"},{"id":"T469","span":{"begin":94,"end":103},"obj":"UMLS/C0851827"},{"id":"T484","span":{"begin":115,"end":123},"obj":"UMLS/C1705908"},{"id":"T500","span":{"begin":104,"end":111},"obj":"UMLS/C1705987"},{"id":"T516","span":{"begin":10,"end":35},"obj":"UMLS/C1819444"},{"id":"T523","span":{"begin":504,"end":509},"obj":"UMLS/C1825592"},{"id":"T515","span":{"begin":309,"end":318},"obj":"UMLS/C1704734"},{"id":"T514","span":{"begin":309,"end":318},"obj":"UMLS/C1704735"},{"id":"T512","span":{"begin":173,"end":182},"obj":"UMLS/C1363844"},{"id":"T508","span":{"begin":554,"end":567},"obj":"UMLS/C0599779"},{"id":"T506","span":{"begin":357,"end":366},"obj":"UMLS/C0332257"},{"id":"T491","span":{"begin":230,"end":242},"obj":"UMLS/C0699748"},{"id":"T483","span":{"begin":371,"end":380},"obj":"UMLS/C0205263"},{"id":"T481","span":{"begin":357,"end":366},"obj":"UMLS/C2700399"},{"id":"T466","span":{"begin":371,"end":380},"obj":"UMLS/C1621983"},{"id":"T451","span":{"begin":492,"end":500},"obj":"UMLS/C0439167"},{"id":"T446","span":{"begin":230,"end":242},"obj":"UMLS/C0543483"},{"id":"T441","span":{"begin":322,"end":328},"obj":"UMLS/C0439662"},{"id":"T425","span":{"begin":357,"end":366},"obj":"UMLS/C1552866"},{"id":"T421","span":{"begin":538,"end":546},"obj":"UMLS/C0039099"},{"id":"T418","span":{"begin":492,"end":500},"obj":"UMLS/C0441655"},{"id":"T401","span":{"begin":510,"end":513},"obj":"UMLS/C2348947"},{"id":"T362","span":{"begin":461,"end":471},"obj":"UMLS/C0185117"},{"id":"T282","span":{"begin":504,"end":509},"obj":"UMLS/C0384648"},{"id":"T274","span":{"begin":492,"end":500},"obj":"UMLS/C1561536"},{"id":"T268","span":{"begin":461,"end":471},"obj":"UMLS/C0017262"},{"id":"T243","span":{"begin":273,"end":284},"obj":"UMLS/C1527200"},{"id":"T223","span":{"begin":504,"end":509},"obj":"UMLS/C1623218"},{"id":"T205","span":{"begin":173,"end":182},"obj":"UMLS/C0127400"},{"id":"T197","span":{"begin":444,"end":456},"obj":"UMLS/C0332120"},{"id":"T193","span":{"begin":160,"end":172},"obj":"UMLS/C0333348"},{"id":"T187","span":{"begin":400,"end":409},"obj":"UMLS/C0079189"},{"id":"T337","span":{"begin":246,"end":266},"obj":"UMLS/C0003873"},{"id":"T318","span":{"begin":333,"end":355},"obj":"UMLS/C1155266"},{"id":"T316","span":{"begin":427,"end":442},"obj":"UMLS/C0005974"},{"id":"T310","span":{"begin":400,"end":409},"obj":"UMLS/C1524094"},{"id":"T300","span":{"begin":273,"end":284},"obj":"UMLS/C0021764"},{"id":"T296","span":{"begin":504,"end":509},"obj":"UMLS/C1522571"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"pmc-enju-pas","denotations":[{"id":"T664","span":{"begin":0,"end":9},"obj":"VB"},{"id":"T665","span":{"begin":10,"end":24},"obj":"NN"},{"id":"T666","span":{"begin":25,"end":35},"obj":"NN"},{"id":"T667","span":{"begin":36,"end":39},"obj":"IN"},{"id":"T668","span":{"begin":40,"end":41},"obj":"DT"},{"id":"T669","span":{"begin":42,"end":58},"obj":"NN"},{"id":"T670","span":{"begin":59,"end":71},"obj":"NN"},{"id":"T671","span":{"begin":72,"end":75},"obj":"CC"},{"id":"T672","span":{"begin":76,"end":83},"obj":"JJ"},{"id":"T673","span":{"begin":84,"end":90},"obj":"NN"},{"id":"T674","span":{"begin":91,"end":102},"obj":"JJ"},{"id":"T675","span":{"begin":102,"end":109},"obj":"NN"},{"id":"T676","span":{"begin":109,"end":111},"obj":"IN"},{"id":"T677","span":{"begin":112,"end":120},"obj":"NN"},{"id":"T678","span":{"begin":120,"end":124},"obj":"IN"},{"id":"T679","span":{"begin":124,"end":134},"obj":"JJ"},{"id":"T680","span":{"begin":134,"end":143},"obj":"NN"},{"id":"T744","span":{"begin":575,"end":583},"obj":"IN"},{"id":"T743","span":{"begin":571,"end":573},"obj":"NN"},{"id":"T742","span":{"begin":568,"end":570},"obj":"IN"},{"id":"T741","span":{"begin":561,"end":567},"obj":"NN"},{"id":"T740","span":{"begin":554,"end":560},"obj":"NN"},{"id":"T739","span":{"begin":551,"end":553},"obj":"IN"},{"id":"T738","span":{"begin":547,"end":550},"obj":"CC"},{"id":"T737","span":{"begin":538,"end":546},"obj":"NN"},{"id":"T736","span":{"begin":535,"end":537},"obj":"NN"},{"id":"T735","span":{"begin":532,"end":534},"obj":"IN"},{"id":"T734","span":{"begin":519,"end":531},"obj":"VB"},{"id":"T733","span":{"begin":514,"end":518},"obj":"VB"},{"id":"T732","span":{"begin":510,"end":513},"obj":"VB"},{"id":"T731","span":{"begin":504,"end":509},"obj":"NN"},{"id":"T730","span":{"begin":501,"end":503},"obj":"IN"},{"id":"T729","span":{"begin":492,"end":500},"obj":"NN"},{"id":"T728","span":{"begin":476,"end":491},"obj":"JJ"},{"id":"T727","span":{"begin":472,"end":475},"obj":"CC"},{"id":"T726","span":{"begin":461,"end":471},"obj":"NN"},{"id":"T725","span":{"begin":457,"end":460},"obj":"DT"},{"id":"T724","span":{"begin":453,"end":456},"obj":"IN"},{"id":"T723","span":{"begin":444,"end":452},"obj":"NN"},{"id":"T722","span":{"begin":432,"end":442},"obj":"NN"},{"id":"T721","span":{"begin":427,"end":431},"obj":"NN"},{"id":"T720","span":{"begin":414,"end":426},"obj":"JJ"},{"id":"T719","span":{"begin":410,"end":413},"obj":"CC"},{"id":"T718","span":{"begin":400,"end":409},"obj":"NN"},{"id":"T717","span":{"begin":384,"end":399},"obj":"JJ"},{"id":"T716","span":{"begin":381,"end":383},"obj":"IN"},{"id":"T715","span":{"begin":371,"end":380},"obj":"NN"},{"id":"T714","span":{"begin":367,"end":370},"obj":"DT"},{"id":"T713","span":{"begin":357,"end":366},"obj":"VB"},{"id":"T712","span":{"begin":355,"end":356},"obj":"-COMMA-"},{"id":"T711","span":{"begin":346,"end":355},"obj":"NN"},{"id":"T710","span":{"begin":333,"end":345},"obj":"JJ"},{"id":"T709","span":{"begin":329,"end":332},"obj":"CC"},{"id":"T708","span":{"begin":322,"end":328},"obj":"JJ"},{"id":"T707","span":{"begin":319,"end":321},"obj":"IN"},{"id":"T706","span":{"begin":309,"end":318},"obj":"NN"},{"id":"T705","span":{"begin":299,"end":308},"obj":"JJ"},{"id":"T704","span":{"begin":296,"end":298},"obj":"DT"},{"id":"T703","span":{"begin":293,"end":295},"obj":"VB"},{"id":"T702","span":{"begin":289,"end":292},"obj":"CD"},{"id":"T701","span":{"begin":288,"end":289},"obj":"-RRB-"},{"id":"T700","span":{"begin":286,"end":288},"obj":"NN"},{"id":"T699","span":{"begin":285,"end":286},"obj":"-LRB-"},{"id":"T698","span":{"begin":273,"end":284},"obj":"NN"},{"id":"T697","span":{"begin":270,"end":271},"obj":"-RRB-"},{"id":"T696","span":{"begin":268,"end":270},"obj":"NN"},{"id":"T695","span":{"begin":267,"end":268},"obj":"-LRB-"},{"id":"T694","span":{"begin":257,"end":266},"obj":"NN"},{"id":"T693","span":{"begin":246,"end":256},"obj":"JJ"},{"id":"T692","span":{"begin":243,"end":245},"obj":"IN"},{"id":"T691","span":{"begin":230,"end":242},"obj":"NN"},{"id":"T690","span":{"begin":226,"end":229},"obj":"DT"},{"id":"T689","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T688","span":{"begin":213,"end":222},"obj":"JJ"},{"id":"T687","span":{"begin":207,"end":212},"obj":"VB"},{"id":"T686","span":{"begin":204,"end":206},"obj":"IN"},{"id":"T685","span":{"begin":193,"end":203},"obj":"VB"},{"id":"T684","span":{"begin":188,"end":192},"obj":"VB"},{"id":"T683","span":{"begin":183,"end":187},"obj":"VB"},{"id":"T682","span":{"begin":173,"end":182},"obj":"NN"},{"id":"T681","span":{"begin":160,"end":172},"obj":"JJ"}],"relations":[{"id":"R108","pred":"arg2Of","subj":"T666","obj":"T664"},{"id":"R109","pred":"arg1Of","subj":"T666","obj":"T665"},{"id":"R110","pred":"arg1Of","subj":"T666","obj":"T667"},{"id":"R111","pred":"arg1Of","subj":"T666","obj":"T671"},{"id":"R112","pred":"arg2Of","subj":"T670","obj":"T667"},{"id":"R113","pred":"arg1Of","subj":"T670","obj":"T668"},{"id":"R114","pred":"arg1Of","subj":"T670","obj":"T669"},{"id":"R115","pred":"arg1Of","subj":"T671","obj":"T676"},{"id":"R116","pred":"arg2Of","subj":"T675","obj":"T671"},{"id":"R117","pred":"arg1Of","subj":"T675","obj":"T672"},{"id":"R118","pred":"arg1Of","subj":"T675","obj":"T673"},{"id":"R119","pred":"arg1Of","subj":"T675","obj":"T674"},{"id":"R120","pred":"arg2Of","subj":"T677","obj":"T676"},{"id":"R121","pred":"arg1Of","subj":"T677","obj":"T678"},{"id":"R122","pred":"arg2Of","subj":"T680","obj":"T678"},{"id":"R123","pred":"arg1Of","subj":"T680","obj":"T679"},{"id":"R124","pred":"arg1Of","subj":"T682","obj":"T681"},{"id":"R125","pred":"arg1Of","subj":"T682","obj":"T683"},{"id":"R126","pred":"arg1Of","subj":"T682","obj":"T684"},{"id":"R127","pred":"arg2Of","subj":"T682","obj":"T685"},{"id":"R128","pred":"arg2Of","subj":"T685","obj":"T683"},{"id":"R129","pred":"arg2Of","subj":"T685","obj":"T684"},{"id":"R130","pred":"arg1Of","subj":"T685","obj":"T686"},{"id":"R131","pred":"arg2Of","subj":"T687","obj":"T686"},{"id":"R132","pred":"arg1Of","subj":"T687","obj":"T689"},{"id":"R133","pred":"arg2Of","subj":"T688","obj":"T687"},{"id":"R134","pred":"arg2Of","subj":"T691","obj":"T689"},{"id":"R135","pred":"arg1Of","subj":"T691","obj":"T690"},{"id":"R136","pred":"arg1Of","subj":"T691","obj":"T692"},{"id":"R137","pred":"arg2Of","subj":"T694","obj":"T692"},{"id":"R138","pred":"arg1Of","subj":"T694","obj":"T693"},{"id":"R139","pred":"arg1Of","subj":"T694","obj":"T695"},{"id":"R140","pred":"arg2Of","subj":"T696","obj":"T695"},{"id":"R141","pred":"arg3Of","subj":"T697","obj":"T695"},{"id":"R142","pred":"arg1Of","subj":"T698","obj":"T699"},{"id":"R143","pred":"arg1Of","subj":"T698","obj":"T702"},{"id":"R144","pred":"arg1Of","subj":"T698","obj":"T703"},{"id":"R145","pred":"arg2Of","subj":"T700","obj":"T699"},{"id":"R146","pred":"arg3Of","subj":"T701","obj":"T699"},{"id":"R147","pred":"arg2Of","subj":"T706","obj":"T703"},{"id":"R148","pred":"arg1Of","subj":"T706","obj":"T704"},{"id":"R149","pred":"arg1Of","subj":"T706","obj":"T705"},{"id":"R150","pred":"arg1Of","subj":"T706","obj":"T707"},{"id":"R151","pred":"arg1Of","subj":"T708","obj":"T709"},{"id":"R152","pred":"arg2Of","subj":"T710","obj":"T709"},{"id":"R153","pred":"arg2Of","subj":"T711","obj":"T707"},{"id":"R154","pred":"arg1Of","subj":"T711","obj":"T708"},{"id":"R155","pred":"arg1Of","subj":"T711","obj":"T710"},{"id":"R156","pred":"arg1Of","subj":"T711","obj":"T712"},{"id":"R157","pred":"arg1Of","subj":"T711","obj":"T713"},{"id":"R158","pred":"arg2Of","subj":"T715","obj":"T713"},{"id":"R159","pred":"arg1Of","subj":"T715","obj":"T714"},{"id":"R160","pred":"arg1Of","subj":"T715","obj":"T716"},{"id":"R161","pred":"arg1Of","subj":"T718","obj":"T717"},{"id":"R162","pred":"arg1Of","subj":"T718","obj":"T719"},{"id":"R163","pred":"arg2Of","subj":"T719","obj":"T716"},{"id":"R164","pred":"arg2Of","subj":"T722","obj":"T719"},{"id":"R165","pred":"arg1Of","subj":"T722","obj":"T720"},{"id":"R166","pred":"arg1Of","subj":"T722","obj":"T721"},{"id":"R167","pred":"arg1Of","subj":"T723","obj":"T724"},{"id":"R168","pred":"arg1Of","subj":"T723","obj":"T727"},{"id":"R169","pred":"arg2Of","subj":"T726","obj":"T724"},{"id":"R170","pred":"arg1Of","subj":"T726","obj":"T725"},{"id":"R171","pred":"arg1Of","subj":"T727","obj":"T732"},{"id":"R172","pred":"arg1Of","subj":"T727","obj":"T733"},{"id":"R173","pred":"arg2Of","subj":"T727","obj":"T734"},{"id":"R174","pred":"arg2Of","subj":"T729","obj":"T727"},{"id":"R175","pred":"arg1Of","subj":"T729","obj":"T728"},{"id":"R176","pred":"arg1Of","subj":"T729","obj":"T730"},{"id":"R177","pred":"arg2Of","subj":"T731","obj":"T730"},{"id":"R178","pred":"arg2Of","subj":"T734","obj":"T732"},{"id":"R179","pred":"arg2Of","subj":"T734","obj":"T733"},{"id":"R180","pred":"arg1Of","subj":"T734","obj":"T735"},{"id":"R181","pred":"arg1Of","subj":"T734","obj":"T739"},{"id":"R182","pred":"arg1Of","subj":"T735","obj":"T738"},{"id":"R183","pred":"arg2Of","subj":"T737","obj":"T735"},{"id":"R184","pred":"arg1Of","subj":"T737","obj":"T736"},{"id":"R185","pred":"arg2Of","subj":"T739","obj":"T738"},{"id":"R186","pred":"arg2Of","subj":"T741","obj":"T739"},{"id":"R187","pred":"arg1Of","subj":"T741","obj":"T740"},{"id":"R188","pred":"arg1Of","subj":"T741","obj":"T742"},{"id":"R189","pred":"arg2Of","subj":"T743","obj":"T742"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T1033","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T1034","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T1036","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1035","span":{"begin":273,"end":292},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T1252","span":{"begin":504,"end":509},"obj":"http://www.uniprot.org/uniprot/Q16552"},{"id":"T1251","span":{"begin":286,"end":292},"obj":"http://www.uniprot.org/uniprot/Q16552"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"GO-BP","denotations":[{"id":"T543","span":{"begin":10,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032740"},{"id":"T545","span":{"begin":10,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032620"},{"id":"T552","span":{"begin":10,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032700"},{"id":"T553","span":{"begin":10,"end":35},"obj":"http://purl.obolibrary.org/obo/GO_0032660"},{"id":"T562","span":{"begin":427,"end":442},"obj":"http://purl.obolibrary.org/obo/GO_0045453"},{"id":"T561","span":{"begin":333,"end":355},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T560","span":{"begin":230,"end":242},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"GO-MF","denotations":[{"id":"T1069","span":{"begin":504,"end":509},"obj":"http://purl.obolibrary.org/obo/GO_0030367"},{"id":"T1068","span":{"begin":286,"end":292},"obj":"http://purl.obolibrary.org/obo/GO_0030367"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"sentences","denotations":[{"id":"T528","span":{"begin":0,"end":149},"obj":"Sentence"},{"id":"T531","span":{"begin":444,"end":574},"obj":"Sentence"},{"id":"T530","span":{"begin":273,"end":443},"obj":"Sentence"},{"id":"T529","span":{"begin":160,"end":272},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":149},"obj":"Sentence"},{"id":"T2","span":{"begin":151,"end":159},"obj":"Sentence"},{"id":"T3","span":{"begin":160,"end":272},"obj":"Sentence"},{"id":"T4","span":{"begin":273,"end":443},"obj":"Sentence"},{"id":"T5","span":{"begin":444,"end":574},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"ICD10","denotations":[{"id":"T1103","span":{"begin":129,"end":149},"obj":"http://purl.bioontology.org/ontology/ICD10/M06.9"},{"id":"T1105","span":{"begin":140,"end":149},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.9"},{"id":"T1104","span":{"begin":246,"end":266},"obj":"http://purl.bioontology.org/ontology/ICD10/M06.9"},{"id":"T1106","span":{"begin":257,"end":266},"obj":"http://purl.bioontology.org/ontology/ICD10/M13.9"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"simple1","denotations":[{"id":"T1216","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T1217","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T1219","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1218","span":{"begin":273,"end":292},"obj":"Protein"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"DLUT931","denotations":[{"id":"T1336","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T1337","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T1371","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T1372","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T1373","span":{"begin":461,"end":471},"obj":"Gene_expression"},{"id":"T1339","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1338","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R543","pred":"themeOf","subj":"T1336","obj":"T1371"},{"id":"R544","pred":"themeOf","subj":"T1339","obj":"T1373"},{"id":"R559","pred":"themeOf","subj":"T1371","obj":"T1372"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T1928","span":{"begin":40,"end":71},"obj":"Entity"},{"id":"T1963","span":{"begin":10,"end":35},"obj":"Protein"},{"id":"T1962","span":{"begin":384,"end":409},"obj":"Protein"},{"id":"T1947","span":{"begin":568,"end":573},"obj":"Protein"},{"id":"T1945","span":{"begin":268,"end":270},"obj":"Protein"},{"id":"T1944","span":{"begin":535,"end":537},"obj":"Protein"},{"id":"T1933","span":{"begin":273,"end":292},"obj":"Protein"},{"id":"T1909","span":{"begin":501,"end":509},"obj":"Protein"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T1443","span":{"begin":0,"end":9},"obj":"VBN"},{"id":"T1444","span":{"begin":10,"end":24},"obj":"JJ"},{"id":"T1445","span":{"begin":25,"end":35},"obj":"NN"},{"id":"T1446","span":{"begin":36,"end":39},"obj":"IN"},{"id":"T1447","span":{"begin":40,"end":41},"obj":"DT"},{"id":"T1448","span":{"begin":42,"end":58},"obj":"NN"},{"id":"T1449","span":{"begin":59,"end":71},"obj":"NN"},{"id":"T1450","span":{"begin":72,"end":75},"obj":"CC"},{"id":"T1451","span":{"begin":76,"end":83},"obj":"JJ"},{"id":"T1452","span":{"begin":84,"end":90},"obj":"NN"},{"id":"T1453","span":{"begin":91,"end":92},"obj":"."},{"id":"T1454","span":{"begin":92,"end":103},"obj":"JJ"},{"id":"T1455","span":{"begin":104,"end":111},"obj":"NN"},{"id":"T1456","span":{"begin":112,"end":114},"obj":"IN"},{"id":"T1457","span":{"begin":115,"end":123},"obj":"NNS"},{"id":"T1458","span":{"begin":124,"end":128},"obj":"IN"},{"id":"T1459","span":{"begin":129,"end":139},"obj":"JJ"},{"id":"T1460","span":{"begin":140,"end":149},"obj":"NNS"},{"id":"T1479","span":{"begin":273,"end":284},"obj":"NNP"},{"id":"T1478","span":{"begin":271,"end":272},"obj":"."},{"id":"T1477","span":{"begin":270,"end":271},"obj":"-RRB-"},{"id":"T1476","span":{"begin":268,"end":270},"obj":"NNP"},{"id":"T1475","span":{"begin":267,"end":268},"obj":"-LRB-"},{"id":"T1474","span":{"begin":257,"end":266},"obj":"NNS"},{"id":"T1473","span":{"begin":246,"end":256},"obj":"JJ"},{"id":"T1472","span":{"begin":243,"end":245},"obj":"IN"},{"id":"T1471","span":{"begin":230,"end":242},"obj":"NN"},{"id":"T1470","span":{"begin":226,"end":229},"obj":"DT"},{"id":"T1469","span":{"begin":223,"end":225},"obj":"IN"},{"id":"T1468","span":{"begin":213,"end":222},"obj":"JJ"},{"id":"T1467","span":{"begin":207,"end":212},"obj":"VBG"},{"id":"T1466","span":{"begin":204,"end":206},"obj":"IN"},{"id":"T1465","span":{"begin":193,"end":203},"obj":"VBN"},{"id":"T1464","span":{"begin":188,"end":192},"obj":"VBN"},{"id":"T1463","span":{"begin":183,"end":187},"obj":"VBP"},{"id":"T1462","span":{"begin":173,"end":182},"obj":"NNS"},{"id":"T1461","span":{"begin":160,"end":172},"obj":"JJ"},{"id":"T1527","span":{"begin":575,"end":583},"obj":"IN"},{"id":"T1526","span":{"begin":573,"end":574},"obj":"."},{"id":"T1525","span":{"begin":571,"end":573},"obj":"NNP"},{"id":"T1524","span":{"begin":568,"end":570},"obj":"IN"},{"id":"T1523","span":{"begin":561,"end":567},"obj":"NNS"},{"id":"T1522","span":{"begin":554,"end":560},"obj":"NN"},{"id":"T1521","span":{"begin":551,"end":553},"obj":"IN"},{"id":"T1520","span":{"begin":547,"end":550},"obj":"CC"},{"id":"T1519","span":{"begin":538,"end":546},"obj":"NN"},{"id":"T1518","span":{"begin":535,"end":537},"obj":"NNP"},{"id":"T1517","span":{"begin":532,"end":534},"obj":"IN"},{"id":"T1516","span":{"begin":519,"end":531},"obj":"VBN"},{"id":"T1515","span":{"begin":514,"end":518},"obj":"VBN"},{"id":"T1514","span":{"begin":510,"end":513},"obj":"VBZ"},{"id":"T1513","span":{"begin":504,"end":509},"obj":"NNP"},{"id":"T1512","span":{"begin":501,"end":503},"obj":"IN"},{"id":"T1511","span":{"begin":492,"end":500},"obj":"NN"},{"id":"T1510","span":{"begin":476,"end":491},"obj":"JJ"},{"id":"T1509","span":{"begin":472,"end":475},"obj":"CC"},{"id":"T1505","span":{"begin":444,"end":452},"obj":"NN"},{"id":"T1504","span":{"begin":442,"end":443},"obj":"."},{"id":"T1503","span":{"begin":432,"end":442},"obj":"NN"},{"id":"T1502","span":{"begin":427,"end":431},"obj":"NN"},{"id":"T1501","span":{"begin":414,"end":426},"obj":"JJ"},{"id":"T1500","span":{"begin":410,"end":413},"obj":"CC"},{"id":"T1499","span":{"begin":400,"end":409},"obj":"NNS"},{"id":"T1498","span":{"begin":384,"end":399},"obj":"JJ"},{"id":"T1497","span":{"begin":381,"end":383},"obj":"IN"},{"id":"T1496","span":{"begin":371,"end":380},"obj":"NN"},{"id":"T1495","span":{"begin":367,"end":370},"obj":"DT"},{"id":"T1494","span":{"begin":357,"end":366},"obj":"VBG"},{"id":"T1493","span":{"begin":355,"end":356},"obj":","},{"id":"T1492","span":{"begin":346,"end":355},"obj":"NNS"},{"id":"T1491","span":{"begin":333,"end":345},"obj":"JJ"},{"id":"T1490","span":{"begin":329,"end":332},"obj":"CC"},{"id":"T1489","span":{"begin":322,"end":328},"obj":"JJ"},{"id":"T1488","span":{"begin":319,"end":321},"obj":"IN"},{"id":"T1487","span":{"begin":309,"end":318},"obj":"NN"},{"id":"T1486","span":{"begin":299,"end":308},"obj":"JJ"},{"id":"T1485","span":{"begin":296,"end":298},"obj":"DT"},{"id":"T1484","span":{"begin":293,"end":295},"obj":"VBZ"},{"id":"T1483","span":{"begin":289,"end":292},"obj":"CD"},{"id":"T1482","span":{"begin":288,"end":289},"obj":"-RRB-"},{"id":"T1481","span":{"begin":286,"end":288},"obj":"NNP"},{"id":"T1480","span":{"begin":285,"end":286},"obj":"-LRB-"},{"id":"T1506","span":{"begin":453,"end":456},"obj":"IN"},{"id":"T1507","span":{"begin":457,"end":460},"obj":"DT"},{"id":"T1508","span":{"begin":461,"end":471},"obj":"NN"}],"relations":[{"id":"R633","pred":"punct","subj":"T1477","obj":"T1471"},{"id":"R634","pred":"punct","subj":"T1478","obj":"T1465"},{"id":"R635","pred":"nmod","subj":"T1479","obj":"T1483"},{"id":"R636","pred":"punct","subj":"T1480","obj":"T1481"},{"id":"R637","pred":"appos","subj":"T1481","obj":"T1479"},{"id":"R638","pred":"punct","subj":"T1482","obj":"T1483"},{"id":"R639","pred":"nsubj","subj":"T1483","obj":"T1484"},{"id":"R640","pred":"ROOT","subj":"T1484","obj":"T1484"},{"id":"R641","pred":"det","subj":"T1485","obj":"T1487"},{"id":"R642","pred":"amod","subj":"T1486","obj":"T1487"},{"id":"R643","pred":"attr","subj":"T1487","obj":"T1484"},{"id":"R644","pred":"prep","subj":"T1488","obj":"T1487"},{"id":"R645","pred":"amod","subj":"T1489","obj":"T1492"},{"id":"R646","pred":"cc","subj":"T1490","obj":"T1489"},{"id":"R647","pred":"conj","subj":"T1491","obj":"T1489"},{"id":"R648","pred":"pobj","subj":"T1492","obj":"T1488"},{"id":"R649","pred":"punct","subj":"T1493","obj":"T1492"},{"id":"R650","pred":"prep","subj":"T1494","obj":"T1492"},{"id":"R651","pred":"det","subj":"T1495","obj":"T1496"},{"id":"R652","pred":"pobj","subj":"T1496","obj":"T1494"},{"id":"R653","pred":"prep","subj":"T1497","obj":"T1496"},{"id":"R654","pred":"amod","subj":"T1498","obj":"T1499"},{"id":"R655","pred":"pobj","subj":"T1499","obj":"T1497"},{"id":"R656","pred":"cc","subj":"T1500","obj":"T1499"},{"id":"R657","pred":"amod","subj":"T1501","obj":"T1503"},{"id":"R658","pred":"compound","subj":"T1502","obj":"T1503"},{"id":"R659","pred":"conj","subj":"T1503","obj":"T1499"},{"id":"R660","pred":"punct","subj":"T1504","obj":"T1484"},{"id":"R661","pred":"nsubjpass","subj":"T1505","obj":"T1516"},{"id":"R662","pred":"cc","subj":"T1509","obj":"T1508"},{"id":"R663","pred":"amod","subj":"T1510","obj":"T1511"},{"id":"R664","pred":"conj","subj":"T1511","obj":"T1508"},{"id":"R665","pred":"prep","subj":"T1512","obj":"T1508"},{"id":"R666","pred":"pobj","subj":"T1513","obj":"T1512"},{"id":"R667","pred":"aux","subj":"T1514","obj":"T1516"},{"id":"R668","pred":"auxpass","subj":"T1515","obj":"T1516"},{"id":"R669","pred":"ROOT","subj":"T1516","obj":"T1516"},{"id":"R670","pred":"prep","subj":"T1517","obj":"T1516"},{"id":"R671","pred":"compound","subj":"T1518","obj":"T1519"},{"id":"R672","pred":"pobj","subj":"T1519","obj":"T1517"},{"id":"R673","pred":"cc","subj":"T1520","obj":"T1517"},{"id":"R674","pred":"conj","subj":"T1521","obj":"T1517"},{"id":"R675","pred":"compound","subj":"T1522","obj":"T1523"},{"id":"R676","pred":"pobj","subj":"T1523","obj":"T1521"},{"id":"R677","pred":"prep","subj":"T1524","obj":"T1523"},{"id":"R678","pred":"pobj","subj":"T1525","obj":"T1524"},{"id":"R679","pred":"punct","subj":"T1526","obj":"T1516"},{"id":"R1064","pred":"prep","subj":"T1506","obj":"T1505"},{"id":"R1065","pred":"det","subj":"T1507","obj":"T1508"},{"id":"R1066","pred":"pobj","subj":"T1508","obj":"T1506"},{"id":"R599","pred":"amod","subj":"T1443","obj":"T1445"},{"id":"R600","pred":"amod","subj":"T1444","obj":"T1445"},{"id":"R601","pred":"ROOT","subj":"T1445","obj":"T1445"},{"id":"R602","pred":"prep","subj":"T1446","obj":"T1445"},{"id":"R603","pred":"det","subj":"T1447","obj":"T1449"},{"id":"R604","pred":"compound","subj":"T1448","obj":"T1449"},{"id":"R605","pred":"pobj","subj":"T1449","obj":"T1446"},{"id":"R606","pred":"cc","subj":"T1450","obj":"T1449"},{"id":"R607","pred":"amod","subj":"T1451","obj":"T1452"},{"id":"R608","pred":"conj","subj":"T1452","obj":"T1449"},{"id":"R609","pred":"punct","subj":"T1453","obj":"T1445"},{"id":"R610","pred":"amod","subj":"T1454","obj":"T1455"},{"id":"R611","pred":"nsubjpass","subj":"T1455","obj":"T1465"},{"id":"R612","pred":"prep","subj":"T1456","obj":"T1455"},{"id":"R613","pred":"pobj","subj":"T1457","obj":"T1456"},{"id":"R614","pred":"prep","subj":"T1458","obj":"T1457"},{"id":"R615","pred":"compound","subj":"T1459","obj":"T1460"},{"id":"R616","pred":"pobj","subj":"T1460","obj":"T1458"},{"id":"R617","pred":"amod","subj":"T1461","obj":"T1462"},{"id":"R618","pred":"nsubjpass","subj":"T1462","obj":"T1465"},{"id":"R619","pred":"aux","subj":"T1463","obj":"T1465"},{"id":"R620","pred":"auxpass","subj":"T1464","obj":"T1465"},{"id":"R621","pred":"ROOT","subj":"T1465","obj":"T1465"},{"id":"R622","pred":"prep","subj":"T1466","obj":"T1465"},{"id":"R623","pred":"pcomp","subj":"T1467","obj":"T1466"},{"id":"R624","pred":"acomp","subj":"T1468","obj":"T1467"},{"id":"R625","pred":"prep","subj":"T1469","obj":"T1467"},{"id":"R626","pred":"det","subj":"T1470","obj":"T1471"},{"id":"R627","pred":"pobj","subj":"T1471","obj":"T1469"},{"id":"R628","pred":"prep","subj":"T1472","obj":"T1471"},{"id":"R629","pred":"amod","subj":"T1473","obj":"T1474"},{"id":"R630","pred":"pobj","subj":"T1474","obj":"T1472"},{"id":"R631","pred":"punct","subj":"T1475","obj":"T1476"},{"id":"R632","pred":"appos","subj":"T1476","obj":"T1471"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T1142","span":{"begin":42,"end":67},"obj":"Protein"},{"id":"T1143","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T1144","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T1145","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T1146","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T1147","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T1150","span":{"begin":461,"end":471},"obj":"Gene_expression"},{"id":"T1149","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T1148","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R481","pred":"themeOf","subj":"T1142","obj":"T1144"},{"id":"R482","pred":"themeOf","subj":"T1143","obj":"T1145"},{"id":"R483","pred":"themeOf","subj":"T1144","obj":"T1146"},{"id":"R484","pred":"themeOf","subj":"T1145","obj":"T1147"},{"id":"R485","pred":"themeOf","subj":"T1149","obj":"T1150"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}

{"project":"testone","denotations":[{"id":"T36","span":{"begin":10,"end":24},"obj":"Protein"},{"id":"T37","span":{"begin":68,"end":71},"obj":"Protein"},{"id":"T71","span":{"begin":0,"end":9},"obj":"Positive_regulation"},{"id":"T72","span":{"begin":25,"end":35},"obj":"Gene_expression"},{"id":"T39","span":{"begin":504,"end":509},"obj":"Protein"},{"id":"T38","span":{"begin":273,"end":292},"obj":"Protein"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T36","obj":"T72"},{"id":"R19","pred":"themeOf","subj":"T72","obj":"T71"}],"text":"Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor κB-dependent pathway in patients with rheumatoid arthritis\n\nAbstract\nInflammatory mediators have been recognized as being important in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-17 is an important regulator of immune and inflammatory responses, including the induction of proinflammatory cytokines and osteoclastic bone resorption. Evidence for the expression and proinflammatory activity of IL-17 has been demonstrated in RA synovium and in animal models of RA. Although"}