PMC:1064873 / 6477-7010
Annnotations
LappsTest
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2_test
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biosemtest
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pmc-enju-pas
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bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T3536","span":{"begin":503,"end":506},"obj":"Protein"},{"id":"T3535","span":{"begin":467,"end":472},"obj":"Protein"},{"id":"T3534","span":{"begin":457,"end":462},"obj":"Protein"},{"id":"T3533","span":{"begin":428,"end":433},"obj":"Protein"},{"id":"T3532","span":{"begin":403,"end":408},"obj":"Protein"},{"id":"T3531","span":{"begin":393,"end":398},"obj":"Protein"},{"id":"T3530","span":{"begin":369,"end":374},"obj":"Protein"},{"id":"T3529","span":{"begin":331,"end":335},"obj":"Protein"},{"id":"T3528","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T3527","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T3526","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T3525","span":{"begin":0,"end":5},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3698","span":{"begin":403,"end":408},"obj":"http://www.uniprot.org/uniprot/P40763"},{"id":"T3689","span":{"begin":428,"end":433},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T3688","span":{"begin":369,"end":374},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T3687","span":{"begin":0,"end":5},"obj":"http://www.uniprot.org/uniprot/P22301"},{"id":"T3864","span":{"begin":457,"end":462},"obj":"http://www.uniprot.org/uniprot/O15524"},{"id":"T3863","span":{"begin":323,"end":326},"obj":"http://www.uniprot.org/uniprot/P09693"},{"id":"T3862","span":{"begin":323,"end":326},"obj":"http://www.uniprot.org/uniprot/P07766"},{"id":"T3861","span":{"begin":323,"end":326},"obj":"http://www.uniprot.org/uniprot/P04234"},{"id":"T3860","span":{"begin":323,"end":326},"obj":"http://www.uniprot.org/uniprot/P20963"},{"id":"T3858","span":{"begin":311,"end":316},"obj":"http://www.uniprot.org/uniprot/P01579"},{"id":"T3852","span":{"begin":331,"end":335},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T3851","span":{"begin":89,"end":93},"obj":"http://www.uniprot.org/uniprot/P10747"},{"id":"T3847","span":{"begin":503,"end":506},"obj":"http://www.uniprot.org/uniprot/P01730"},{"id":"T3846","span":{"begin":231,"end":234},"obj":"http://www.uniprot.org/uniprot/P01730"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
UBERON-AE
{"project":"UBERON-AE","denotations":[{"id":"T2429","span":{"begin":492,"end":497},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T3310","span":{"begin":53,"end":70},"obj":"http://purl.obolibrary.org/obo/GO_0034097"},{"id":"T3309","span":{"begin":46,"end":61},"obj":"http://purl.obolibrary.org/obo/GO_0002369"},{"id":"T3284","span":{"begin":94,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T3274","span":{"begin":409,"end":424},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T3592","span":{"begin":510,"end":515},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3591","span":{"begin":238,"end":243},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3590","span":{"begin":193,"end":198},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3589","span":{"begin":48,"end":52},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T3551","span":{"begin":428,"end":433},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T3550","span":{"begin":369,"end":374},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T3549","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
sentences
{"project":"sentences","denotations":[{"id":"T3258","span":{"begin":200,"end":533},"obj":"Sentence"},{"id":"T3257","span":{"begin":0,"end":199},"obj":"Sentence"},{"id":"T34","span":{"begin":0,"end":199},"obj":"Sentence"},{"id":"T35","span":{"begin":200,"end":533},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
simple1
{"project":"simple1","denotations":[{"id":"T3939","span":{"begin":503,"end":506},"obj":"Protein"},{"id":"T3938","span":{"begin":467,"end":472},"obj":"Protein"},{"id":"T3937","span":{"begin":457,"end":462},"obj":"Protein"},{"id":"T3936","span":{"begin":428,"end":433},"obj":"Protein"},{"id":"T3935","span":{"begin":403,"end":408},"obj":"Protein"},{"id":"T3934","span":{"begin":393,"end":398},"obj":"Protein"},{"id":"T3933","span":{"begin":369,"end":374},"obj":"Protein"},{"id":"T3932","span":{"begin":331,"end":335},"obj":"Protein"},{"id":"T3931","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T3930","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T3929","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T3928","span":{"begin":0,"end":5},"obj":"Protein"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T6472","span":{"begin":443,"end":453},"obj":"Gene_expression"},{"id":"T6449","span":{"begin":503,"end":506},"obj":"Protein"},{"id":"T6448","span":{"begin":467,"end":472},"obj":"Protein"},{"id":"T6447","span":{"begin":457,"end":462},"obj":"Protein"},{"id":"T6446","span":{"begin":428,"end":433},"obj":"Protein"},{"id":"T6445","span":{"begin":403,"end":408},"obj":"Protein"},{"id":"T6444","span":{"begin":393,"end":398},"obj":"Protein"},{"id":"T6443","span":{"begin":369,"end":374},"obj":"Protein"},{"id":"T6442","span":{"begin":331,"end":335},"obj":"Protein"},{"id":"T6441","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T6440","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T6439","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T6438","span":{"begin":0,"end":5},"obj":"Protein"},{"id":"T6475","span":{"begin":297,"end":307},"obj":"Gene_expression"},{"id":"T6474","span":{"begin":409,"end":424},"obj":"Phosphorylation"},{"id":"T6473","span":{"begin":380,"end":389},"obj":"Positive_regulation"}],"relations":[{"id":"R3174","pred":"themeOf","subj":"T6441","obj":"T6475"},{"id":"R3175","pred":"themeOf","subj":"T6444","obj":"T6473"},{"id":"R3176","pred":"themeOf","subj":"T6444","obj":"T6474"},{"id":"R3177","pred":"themeOf","subj":"T6445","obj":"T6473"},{"id":"R3178","pred":"themeOf","subj":"T6445","obj":"T6474"},{"id":"R3179","pred":"causeOf","subj":"T6446","obj":"T6473"},{"id":"R3180","pred":"causeOf","subj":"T6446","obj":"T6473"},{"id":"R3181","pred":"causeOf","subj":"T6446","obj":"T6473"},{"id":"R3182","pred":"causeOf","subj":"T6446","obj":"T6473"},{"id":"R3183","pred":"themeOf","subj":"T6447","obj":"T6472"},{"id":"R3184","pred":"themeOf","subj":"T6448","obj":"T6472"},{"id":"R3190","pred":"themeOf","subj":"T6474","obj":"T6473"},{"id":"R3191","pred":"themeOf","subj":"T6474","obj":"T6473"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T4914","span":{"begin":297,"end":307},"obj":"Gene_expression"},{"id":"T4913","span":{"begin":443,"end":453},"obj":"Gene_expression"},{"id":"T4912","span":{"begin":380,"end":389},"obj":"Positive_regulation"},{"id":"T4911","span":{"begin":409,"end":424},"obj":"Phosphorylation"},{"id":"T4887","span":{"begin":503,"end":506},"obj":"Protein"},{"id":"T4886","span":{"begin":467,"end":472},"obj":"Protein"},{"id":"T4885","span":{"begin":457,"end":462},"obj":"Protein"},{"id":"T4884","span":{"begin":428,"end":433},"obj":"Protein"},{"id":"T4883","span":{"begin":403,"end":408},"obj":"Protein"},{"id":"T4882","span":{"begin":393,"end":398},"obj":"Protein"},{"id":"T4881","span":{"begin":369,"end":374},"obj":"Protein"},{"id":"T4880","span":{"begin":331,"end":335},"obj":"Protein"},{"id":"T4879","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T4878","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T4877","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T4876","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R1940","pred":"themeOf","subj":"T4879","obj":"T4914"},{"id":"R1943","pred":"themeOf","subj":"T4882","obj":"T4912"},{"id":"R1945","pred":"themeOf","subj":"T4882","obj":"T4911"},{"id":"R1948","pred":"themeOf","subj":"T4883","obj":"T4912"},{"id":"R1951","pred":"themeOf","subj":"T4883","obj":"T4911"},{"id":"R1952","pred":"causeOf","subj":"T4884","obj":"T4912"},{"id":"R1954","pred":"causeOf","subj":"T4884","obj":"T4912"},{"id":"R1955","pred":"causeOf","subj":"T4884","obj":"T4912"},{"id":"R1957","pred":"causeOf","subj":"T4884","obj":"T4912"},{"id":"R1960","pred":"themeOf","subj":"T4885","obj":"T4913"},{"id":"R1962","pred":"themeOf","subj":"T4886","obj":"T4913"},{"id":"R1980","pred":"themeOf","subj":"T4911","obj":"T4912"},{"id":"R1981","pred":"themeOf","subj":"T4911","obj":"T4912"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T5934","span":{"begin":280,"end":292},"obj":"Positive_regulation"},{"id":"T5933","span":{"begin":443,"end":453},"obj":"Gene_expression"},{"id":"T5932","span":{"begin":409,"end":424},"obj":"Phosphorylation"},{"id":"T5931","span":{"begin":380,"end":389},"obj":"Positive_regulation"},{"id":"T5930","span":{"begin":336,"end":349},"obj":"Positive_regulation"},{"id":"T5929","span":{"begin":297,"end":307},"obj":"Gene_expression"},{"id":"T5928","span":{"begin":74,"end":84},"obj":"Negative_regulation"},{"id":"T5899","span":{"begin":503,"end":506},"obj":"Protein"},{"id":"T5898","span":{"begin":467,"end":472},"obj":"Protein"},{"id":"T5897","span":{"begin":457,"end":462},"obj":"Protein"},{"id":"T5896","span":{"begin":428,"end":433},"obj":"Protein"},{"id":"T5895","span":{"begin":403,"end":408},"obj":"Protein"},{"id":"T5894","span":{"begin":393,"end":398},"obj":"Protein"},{"id":"T5893","span":{"begin":369,"end":374},"obj":"Protein"},{"id":"T5892","span":{"begin":331,"end":335},"obj":"Protein"},{"id":"T5891","span":{"begin":311,"end":316},"obj":"Protein"},{"id":"T5890","span":{"begin":231,"end":234},"obj":"Protein"},{"id":"T5889","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T5888","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R2935","pred":"themeOf","subj":"T5894","obj":"T5931"},{"id":"R2936","pred":"themeOf","subj":"T5894","obj":"T5932"},{"id":"R2937","pred":"themeOf","subj":"T5895","obj":"T5931"},{"id":"R2938","pred":"themeOf","subj":"T5895","obj":"T5932"},{"id":"R2939","pred":"causeOf","subj":"T5896","obj":"T5931"},{"id":"R2940","pred":"causeOf","subj":"T5896","obj":"T5931"},{"id":"R2941","pred":"causeOf","subj":"T5896","obj":"T5931"},{"id":"R2942","pred":"causeOf","subj":"T5896","obj":"T5931"},{"id":"R2943","pred":"causeOf","subj":"T5896","obj":"T5931"},{"id":"R2944","pred":"themeOf","subj":"T5897","obj":"T5933"},{"id":"R2945","pred":"themeOf","subj":"T5898","obj":"T5933"},{"id":"R2967","pred":"causeOf","subj":"T5888","obj":"T5928"},{"id":"R2968","pred":"themeOf","subj":"T5889","obj":"T5928"},{"id":"R2969","pred":"themeOf","subj":"T5891","obj":"T5929"},{"id":"R2976","pred":"themeOf","subj":"T5892","obj":"T5930"},{"id":"R2977","pred":"themeOf","subj":"T5929","obj":"T5934"},{"id":"R2978","pred":"themeOf","subj":"T5929","obj":"T5930"},{"id":"R2979","pred":"themeOf","subj":"T5929","obj":"T5931"},{"id":"R2980","pred":"themeOf","subj":"T5931","obj":"T5934"},{"id":"R2981","pred":"themeOf","subj":"T5931","obj":"T5934"},{"id":"R2982","pred":"themeOf","subj":"T5931","obj":"T5934"},{"id":"R2984","pred":"themeOf","subj":"T5932","obj":"T5931"},{"id":"R2985","pred":"themeOf","subj":"T5932","obj":"T5931"},{"id":"R2986","pred":"themeOf","subj":"T5933","obj":"T5934"},{"id":"R2987","pred":"themeOf","subj":"T5933","obj":"T5934"}],"text":"IL-10 efficiently blocks the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway [24], as well as indirectly by downregulating the function of antigen-presenting cells. To elucidate the resistance of CD4+ T cells to this direct inhibition in RA, we investigated the production of IFN-γ after CD3 and CD28 costimulation in the presence of IL-10, the induction of STAT1 and STAT3 phosphorylation by IL-10, and the expression of SOCS1 and SOCS3 mRNA in peripheral blood (PB) CD4+ T cells from RA patients."}
bionlp-st-ge-2016-test-ihmc
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bionlp-st-ge-2016-spacy-parsed
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bionlp-st-ge-2016-test-tees
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test3
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testone
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