PMC:1064873 / 4402-5230
Annnotations
LappsTest
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2_test
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biosemtest
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bionlp-st-ge-2016-test-proteins
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bionlp-st-ge-2016-uniprot
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UBERON-AE
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GO-BP
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GO-CC
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GO-MF
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sentences
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simple1
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BioNLP16_DUT
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BioNLP16_Messiy
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DLUT931
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bionlp-st-ge-2016-test-ihmc
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test3
{"project":"test3","denotations":[{"id":"T2388","span":{"begin":774,"end":822},"obj":"Protein"},{"id":"T2387","span":{"begin":764,"end":768},"obj":"Protein"},{"id":"T2386","span":{"begin":757,"end":762},"obj":"Protein"},{"id":"T2385","span":{"begin":734,"end":737},"obj":"Positive_regulation"},{"id":"T2384","span":{"begin":690,"end":699},"obj":"Negative_regulation"},{"id":"T2383","span":{"begin":679,"end":686},"obj":"Protein"},{"id":"T2382","span":{"begin":665,"end":675},"obj":"Gene_expression"},{"id":"T2381","span":{"begin":617,"end":621},"obj":"Protein"},{"id":"T2380","span":{"begin":607,"end":612},"obj":"Protein"},{"id":"T2379","span":{"begin":524,"end":532},"obj":"Negative_regulation"},{"id":"T2378","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T2377","span":{"begin":410,"end":415},"obj":"Protein"},{"id":"T2376","span":{"begin":119,"end":127},"obj":"Gene_expression"},{"id":"T2375","span":{"begin":112,"end":117},"obj":"Protein"},{"id":"T2301","span":{"begin":774,"end":822},"obj":"Protein"},{"id":"T2300","span":{"begin":764,"end":768},"obj":"Protein"},{"id":"T2299","span":{"begin":757,"end":762},"obj":"Protein"},{"id":"T2298","span":{"begin":679,"end":686},"obj":"Protein"},{"id":"T2297","span":{"begin":617,"end":621},"obj":"Protein"},{"id":"T2296","span":{"begin":607,"end":612},"obj":"Protein"},{"id":"T2295","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T2294","span":{"begin":410,"end":415},"obj":"Protein"},{"id":"T2293","span":{"begin":112,"end":117},"obj":"Protein"}],"relations":[{"id":"R804","pred":"themeOf","subj":"T2375","obj":"T2376"},{"id":"R805","pred":"themeOf","subj":"T2382","obj":"T2384"},{"id":"R806","pred":"themeOf","subj":"T2382","obj":"T2385"},{"id":"R807","pred":"themeOf","subj":"T2383","obj":"T2382"},{"id":"R808","pred":"causeOf","subj":"T2386","obj":"T2385"},{"id":"R809","pred":"causeOf","subj":"T2387","obj":"T2385"},{"id":"R810","pred":"causeOf","subj":"T2388","obj":"T2384"},{"id":"R811","pred":"causeOf","subj":"T2388","obj":"T2385"}],"text":"However, anti-inflammatory cytokines and cytokine inhibitors are also present in large quantities in RA joints. IL-10, produced by macrophages and partly by T cells in the synovial tissue (ST), is best known as a negative regulator for macrophage and Th1 cells, but the expression level is insufficient to counterbalance the cascade of proinflammatory events [12]. In addition, the anti-inflammatory action of IL-10 appears to be modulated at the level of signal transduction during chronic inflammation. IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1 and immune complexes [13,14]. Cell surface expression of IL-10R1 is decreased in synovial fluid dendritic cells due to the presence of TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15]."}
testone
{"project":"testone","denotations":[{"id":"T2115","span":{"begin":774,"end":822},"obj":"Protein"},{"id":"T2114","span":{"begin":764,"end":768},"obj":"Protein"},{"id":"T2113","span":{"begin":757,"end":762},"obj":"Protein"},{"id":"T2112","span":{"begin":679,"end":686},"obj":"Protein"},{"id":"T2111","span":{"begin":617,"end":621},"obj":"Protein"},{"id":"T2093","span":{"begin":607,"end":612},"obj":"Protein"},{"id":"T2092","span":{"begin":505,"end":510},"obj":"Protein"},{"id":"T2091","span":{"begin":410,"end":415},"obj":"Protein"},{"id":"T2090","span":{"begin":112,"end":117},"obj":"Protein"},{"id":"T2166","span":{"begin":690,"end":699},"obj":"Negative_regulation"},{"id":"T2165","span":{"begin":665,"end":675},"obj":"Gene_expression"},{"id":"T2164","span":{"begin":524,"end":532},"obj":"Negative_regulation"},{"id":"T2163","span":{"begin":270,"end":280},"obj":"Gene_expression"},{"id":"T2162","span":{"begin":119,"end":127},"obj":"Gene_expression"}],"relations":[{"id":"R726","pred":"themeOf","subj":"T2090","obj":"T2163"},{"id":"R727","pred":"themeOf","subj":"T2090","obj":"T2162"},{"id":"R728","pred":"causeOf","subj":"T2093","obj":"T2164"},{"id":"R742","pred":"causeOf","subj":"T2111","obj":"T2164"},{"id":"R743","pred":"themeOf","subj":"T2112","obj":"T2165"},{"id":"R744","pred":"causeOf","subj":"T2113","obj":"T2166"},{"id":"R745","pred":"causeOf","subj":"T2114","obj":"T2166"},{"id":"R746","pred":"causeOf","subj":"T2115","obj":"T2166"},{"id":"R764","pred":"themeOf","subj":"T2165","obj":"T2166"}],"text":"However, anti-inflammatory cytokines and cytokine inhibitors are also present in large quantities in RA joints. IL-10, produced by macrophages and partly by T cells in the synovial tissue (ST), is best known as a negative regulator for macrophage and Th1 cells, but the expression level is insufficient to counterbalance the cascade of proinflammatory events [12]. In addition, the anti-inflammatory action of IL-10 appears to be modulated at the level of signal transduction during chronic inflammation. IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1 and immune complexes [13,14]. Cell surface expression of IL-10R1 is decreased in synovial fluid dendritic cells due to the presence of TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15]."}